human

Summary

Alias: man, Homo sapiens, Homo sapiens Linnaeus, 1758

Top Publications

  1. Lei Y, Hu X, Li B, Peng M, Tong S, Zu X, et al. miR-150 modulates cisplatin chemosensitivity and invasiveness of muscle-invasive bladder cancer cells via targeting PDCD4 in vitro. Med Sci Monit. 2014;20:1850-7 pubmed publisher
    ..Thus, modulation of the miR-150-PDCD4 axis shows promise as a therapeutic strategy for MIBC. ..
  2. Arsenault B, Pelletier Beaumont E, Almeras N, Tremblay A, Poirier P, Bergeron J, et al. PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program. Atherosclerosis. 2014;236:321-6 pubmed publisher
    ....
  3. Foulkes W, Priest J, Duchaine T. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer. 2014;14:662-72 pubmed publisher
    ..This Review reflects on the molecular properties of the Dicer enzymes in small RNA silencing pathways, and rationalizes the newly discovered mutations on the basis of the activities and functions of its determinants...
  4. Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky J, Desrichard A, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189-2199 pubmed publisher
    ..Funded by the Frederick Adler Fund and others.). ..
  5. Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, et al. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014;127:4679-91 pubmed publisher
    ..Our findings reveal a coordinated action between CRL4B and SIN3A-HDAC complexes in transcriptional repression. ..
  6. Hoskins J, Jia J, Flandez M, Parikh H, Xiao W, Collins I, et al. Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A. Carcinogenesis. 2014;35:2670-8 pubmed publisher
    ..g. CASP4/9/10 and APAF1). In light of the established role of HNF1A in the regulation of pancreatic development and homeostasis, our data suggest that it also functions as an important tumor suppressor in the pancreas. ..
  7. Vanlander A, Menten B, Smet J, De Meirleir L, Sante T, De Paepe B, et al. Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2). Hum Mutat. 2015;36:222-31 pubmed publisher
    ..This confirmed the pathogenic nature of the variant. To conclude, the reported variant in NARS2 results in a combined OXPHOS complex deficiency involving complex I and IV, making NARS2 a new member of disease-associated aaRS2. ..
  8. Amorim N, da Silva E, de Castro R, da Silva Januário M, Mendonça L, Bonifacino J, et al. Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem. 2014;289:27744-56 pubmed publisher
    Nef is an accessory protein of human immunodeficiency viruses that promotes viral replication and progression to AIDS through interference with various host trafficking and signaling pathways...
  9. Oblak A, Jerala R. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2. PLoS ONE. 2014;9:e107520 pubmed publisher
    ..In hypoacylated endotoxins all acyl chains could be accommodated within the binding pocket of the human hMD-2. Nevertheless, tetra- and pentaacylated endotoxins activate the TLR4/MD-2 receptor of several species...
  10. Wendt L, Albring A, Benson S, Engler H, Engler A, Hinney A, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS ONE. 2014;9:e107665 pubmed publisher
    ..Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimize nocebo effects in clinical trials and medical practice. ..

Detail Information

Publications175 found, 100 shown here

  1. Lei Y, Hu X, Li B, Peng M, Tong S, Zu X, et al. miR-150 modulates cisplatin chemosensitivity and invasiveness of muscle-invasive bladder cancer cells via targeting PDCD4 in vitro. Med Sci Monit. 2014;20:1850-7 pubmed publisher
    ..Thus, modulation of the miR-150-PDCD4 axis shows promise as a therapeutic strategy for MIBC. ..
  2. Arsenault B, Pelletier Beaumont E, Almeras N, Tremblay A, Poirier P, Bergeron J, et al. PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program. Atherosclerosis. 2014;236:321-6 pubmed publisher
    ....
  3. Foulkes W, Priest J, Duchaine T. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer. 2014;14:662-72 pubmed publisher
    ..This Review reflects on the molecular properties of the Dicer enzymes in small RNA silencing pathways, and rationalizes the newly discovered mutations on the basis of the activities and functions of its determinants...
  4. Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky J, Desrichard A, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189-2199 pubmed publisher
    ..Funded by the Frederick Adler Fund and others.). ..
  5. Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, et al. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 2014;127:4679-91 pubmed publisher
    ..Our findings reveal a coordinated action between CRL4B and SIN3A-HDAC complexes in transcriptional repression. ..
  6. Hoskins J, Jia J, Flandez M, Parikh H, Xiao W, Collins I, et al. Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A. Carcinogenesis. 2014;35:2670-8 pubmed publisher
    ..g. CASP4/9/10 and APAF1). In light of the established role of HNF1A in the regulation of pancreatic development and homeostasis, our data suggest that it also functions as an important tumor suppressor in the pancreas. ..
  7. Vanlander A, Menten B, Smet J, De Meirleir L, Sante T, De Paepe B, et al. Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2). Hum Mutat. 2015;36:222-31 pubmed publisher
    ..This confirmed the pathogenic nature of the variant. To conclude, the reported variant in NARS2 results in a combined OXPHOS complex deficiency involving complex I and IV, making NARS2 a new member of disease-associated aaRS2. ..
  8. Amorim N, da Silva E, de Castro R, da Silva Januário M, Mendonça L, Bonifacino J, et al. Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem. 2014;289:27744-56 pubmed publisher
    Nef is an accessory protein of human immunodeficiency viruses that promotes viral replication and progression to AIDS through interference with various host trafficking and signaling pathways...
  9. Oblak A, Jerala R. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2. PLoS ONE. 2014;9:e107520 pubmed publisher
    ..In hypoacylated endotoxins all acyl chains could be accommodated within the binding pocket of the human hMD-2. Nevertheless, tetra- and pentaacylated endotoxins activate the TLR4/MD-2 receptor of several species...
  10. Wendt L, Albring A, Benson S, Engler H, Engler A, Hinney A, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS ONE. 2014;9:e107665 pubmed publisher
    ..Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimize nocebo effects in clinical trials and medical practice. ..
  11. Iossifov I, O Roak B, Sanders S, Ronemus M, Krumm N, Levy D, et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature. 2014;515:216-21 pubmed publisher
    Whole exome sequencing has proven to be a powerful tool for understanding the genetic architecture of human disease. Here we apply it to more than 2,500 simplex families, each having a child with an autistic spectrum disorder...
  12. Lee N, Lee J, Park C, Yu D, Lee Y, Cheong J, et al. Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma. Biochem Biophys Res Commun. 2014;451:171-8 pubmed publisher
    ..We found that HOTAIR was involved in inhibition of apoptosis and promoted invasiveness, supporting a role for HOTAIR in carcinogenesis and progression of gastric cancer. ..
  13. Xu X, Wells A, Padilla M, Kato K, Kim K, Lin Y. A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis. 2014;35:2457-66 pubmed publisher
    ..While the oncoprotein Mucin-1 (MUC1) performs multiple roles in the development of diverse human tumors, whether MUC1 is involved in acquired chemoresistance has not been determined...
  14. May S, Hornburg D, Schludi M, Arzberger T, Rentzsch K, Schwenk B, et al. C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol. 2014;128:485-503 pubmed publisher
    ..Poly-GA-induced Unc119 loss of function may thereby contribute to selective vulnerability of neurons with DPR protein inclusions in the pathogenesis of C9orf72 FTLD/ALS. ..
  15. Friedrich D, Genro J, Sortica V, Suarez Kurtz G, de Moraes M, Pena S, et al. Distribution of CYP2D6 alleles and phenotypes in the Brazilian population. PLoS ONE. 2014;9:e110691 pubmed publisher
    ....
  16. Fan H, Sun X, Guo W, Zhong A, Niu W, Zhao L, et al. Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients. J Psychiatr Res. 2014;59:45-52 pubmed publisher
    ..By using an Affymetrix array that covers 723 human miRNAs, we identified 26 miRNAs with significant changes in expression in PBMCs of MDD patients...
  17. Alsaadi M, Erzurumluoglu A, Rodriguez S, Guthrie P, Gaunt T, Omar H, et al. Nonsense mutation in coiled-coil domain containing 151 gene (CCDC151) causes primary ciliary dyskinesia. Hum Mutat. 2014;35:1446-8 pubmed publisher
    ..Our finding also shows that given prior knowledge from model organisms, even a single whole-exome sequence can be sufficient to discover a novel causal gene. ..
  18. St Pourcain B, Cents R, Whitehouse A, Haworth C, Davis O, O Reilly P, et al. Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nat Commun. 2014;5:4831 pubmed publisher
    ..13, meta-GCTA h(2)(24-30-months) = 0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h(2)(24-months) = 0.20). ..
  19. Hendershot J, O Brien P. Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping. Nucleic Acids Res. 2014;42:12681-90 pubmed publisher
    ..mutagenesis and transient kinetic approaches to dissect the energetic contribution of intercalation for human alkyladenine DNA glycosylase, an enzyme that initiates repair of alkylation damage...
  20. Gjyshi O, Bottero V, Veettil M, Dutta S, Singh V, Chikoti L, et al. Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. PLoS Pathog. 2014;10:e1004460 pubmed publisher
    ..KSHV induces reactive oxygen species (ROS) early during infection of human dermal microvascular endothelial (HMVEC-d) cells that are critical for virus entry...
  21. Tu K, Zheng X, Dou C, Li C, Yang W, Yao Y, et al. MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome proliferator-activated receptor gamma in human hepatocellular carcinoma. Int J Mol Sci. 2014;15:20486-99 pubmed publisher
    ..Notably, PPAR-? knockdown abolished down-regulation of miR-130b-inhibited EMT in MHCC97H cells. In conclusion, miR-130b may promote HCC cell migration and invasion by inhibiting PPAR-? and subsequently inducing EMT. ..
  22. Pignatelli J, Goswami S, Jones J, Rohan T, Pieri E, Chen X, et al. Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Sci Signal. 2014;7:ra112 pubmed publisher
    ..patients and found that, in an in vitro transendothelial migration assay, cells that migrated through a layer of human endothelial cells were enriched for the transcript encoding Mena(INV), an invasive isoform of Mena...
  23. Xie H, Liu T, Wang N, Björnhagen V, Höög A, Larsson C, et al. TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma. Oncotarget. 2014;5:10048-57 pubmed
    ..and clinical significance underlying cancer-specific TERT expression have been extensively investigated in various human malignancies, but little is known about these in Merkel cell carcinoma (MCC), an aggressive neuroendocrine skin ..
  24. Wang Z, Cui W, Yang L, Zhu Y, Wei W. Association of dietary intake of folate and MTHFR genotype with breast cancer risk. Genet Mol Res. 2014;13:5446-51 pubmed publisher
    ..We found any interaction between MTHFR C677T and folate intake (P for interaction = 0.02). In conclusion, our study demonstrated that MTHFR C677T polymorphism and folate are associated with risk of breast cancer. ..
  25. Borge M, Remes Lenicov F, Nannini P, de los Ríos Alicandú M, Podaza E, Ceballos A, et al. The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. J Immunol. 2014;193:3165-74 pubmed publisher
    ..Based on our results, we suggest that the regulated expression of S1PR1 might modulate the egress of the leukemic clone from lymphoid tissues. ..
  26. Eguether T, Ermolaeva M, Zhao Y, Bonnet M, Jain A, Pasparakis M, et al. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 2014;5:4585 pubmed publisher
    ..These results point to an undiscovered regulation of ciliogenesis by Lys63 ubiquitination and provide new perspectives regarding CYLD function that should be considered in the context of cylindromatosis...
  27. Leblond C, Nava C, Polge A, Gauthier J, Huguet G, Lumbroso S, et al. Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments. PLoS Genet. 2014;10:e1004580 pubmed publisher
    ..In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice. ..
  28. Daley J, Chiba T, Xue X, Niu H, Sung P. Multifaceted role of the Topo III?-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection. Nucleic Acids Res. 2014;42:11083-91 pubmed publisher
    ..Herein, we address the role of Topo III? and RMI1-RMI2 in resection using a reconstituted system with purified human proteins...
  29. Lee J, Chung L, Chen Y, Feng T, Juang H. N-myc downstream-regulated gene 1 downregulates cell proliferation, invasiveness, and tumorigenesis in human oral squamous cell carcinoma. Cancer Lett. 2014;355:242-52 pubmed publisher
    ..The downregulation of EMT, MMP-2, and MMP-9 may explain the role of anti-invasion of NDRG1 in human OSCC cells. The experiments recognize that NDRG1 is an antitumor gene in OSCC cells.
  30. Ghosh D, Sahay S, Ranjan P, Salot S, Mohite G, Singh P, et al. The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates ?-synuclein aggregation and membrane binding. Biochemistry. 2014;53:6419-21 pubmed publisher
    ..Further, A53E showed reduced membrane binding affinity compared to A53T and WT. The present study would help to delineate the role of A53E mutation in early onset PD pathogenesis. ..
  31. Aligeti M, Behrens R, Pocock G, Schindelin J, Dietz C, Eliceiri K, et al. Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. J Virol. 2014;88:14207-21 pubmed publisher
    ..version of the chromosomal region maintenance 1 (mCRM1) nuclear export receptor and rescued by the expression of human CRM1 (hCRM1)...
  32. Sugathan A, Biagioli M, Golzio C, Erdin S, Blumenthal I, Manavalan P, et al. CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. Proc Natl Acad Sci U S A. 2014;111:E4468-77 pubmed publisher
    ..These data indicate that heterozygous disruption of CHD8 precipitates a network of gene-expression changes involved in neurodevelopmental pathways in which many ASD-associated genes may converge on shared mechanisms of pathogenesis...
  33. Xi X, Liu Y, Lu Y, Huang L, Qin X, Li S. Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population. Med Oncol. 2015;32:355 pubmed publisher
    ..However, the ACA and GCG haplotypes in the IL-17 gene might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population. ..
  34. Lim J, Ha M, Chang H, Kwon S, Simanshu D, Patel D, et al. Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell. 2014;159:1365-76 pubmed publisher
    ..Our study explains the mechanism underlying selective uridylation of deadenylated mRNAs and demonstrates a fundamental role of oligo-U-tail as a molecular mark for global mRNA decay. ..
  35. Cui Y, Jiang D, Zhang S, Wu P, Ye Y, Chen C, et al. FOXC2 promotes colorectal cancer proliferation through inhibition of FOXO3a and activation of MAPK and AKT signaling pathways. Cancer Lett. 2014;353:87-94 pubmed publisher
    Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized...
  36. Xu J, Yue C, Zhou W, Qian Y, Zhang Y, Wang S, et al. Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis. J Transl Med. 2014;12:200 pubmed publisher
    ..Aurora-A might serve as a predictive biomarker of drug response and therapeutic target to reverse chemotherapy resistance. ..
  37. Wang X, Ren H, Zhao T, Chen J, Sun W, Sun Y, et al. Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection. Carcinogenesis. 2014;35:2283-90 pubmed publisher
    ..Uncontrolled activity of SCF/c-kit signaling pathway contributes to the formation of a variety of human malignancies...
  38. Luo J, Wärmländer S, Gräslund A, Abrahams J. Non-chaperone proteins can inhibit aggregation and cytotoxicity of Alzheimer amyloid ? peptide. J Biol Chem. 2014;289:27766-75 pubmed publisher
    ..We propose general mechanisms for the broad-spectrum inhibition A? fibrillation by proteins. The mechanisms we discuss are significant for prognostics and perhaps even for prevention and treatment of Alzheimer disease. ..
  39. Tung M, Wang Y, Yeh S, Wu C, Chen K, Huang Z, et al. Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population. J Formos Med Assoc. 2014;113:640-7 pubmed publisher
    ..The present study provided epidemiological evidence for a significantly increased risk of UCB in ever smokers with the Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene. ..
  40. Chamberlain P, Lopez Girona A, Miller K, Carmel G, Pagarigan B, Chie Leon B, et al. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol. 2014;21:803-9 pubmed publisher
    ..Here we present the crystal structure of human CRBN bound to DDB1 and the drug lenalidomide...
  41. Bu Q, Fang Y, Cao Y, Chen Q, Liu Y. Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. Mol Med Rep. 2014;10:2203-9 pubmed publisher
    ..However, the possible role of miR?101 in cisplatin sensitivity in human bladder cancer cells remains unclear...
  42. DeGiorgio M, Lohmueller K, Nielsen R. A model-based approach for identifying signatures of ancient balancing selection in genetic data. PLoS Genet. 2014;10:e1004561 pubmed publisher
    While much effort has focused on detecting positive and negative directional selection in the human genome, relatively little work has been devoted to balancing selection...
  43. Jeppsson K, Kanno T, Shirahige K, Sjögren C. The maintenance of chromosome structure: positioning and functioning of SMC complexes. Nat Rev Mol Cell Biol. 2014;15:601-14 pubmed publisher
    ....
  44. Jia Y, Zang A, Shang Y, Yang H, Song Z, Wang Z, et al. MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population. Med Oncol. 2014;31:194 pubmed publisher
    ..0022). It confirmed that the SNP rs2910164 could functionally affect the miR-146a expression levels. In conclusion, it showed that the rs2910164 polymorphism of miR-146a is associated with the risk of NSCLC in the Chinese population. ..
  45. Wei J, Ma Z, Li Y, Zhao B, Wang D, Jin Y, et al. miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells. Mol Med Rep. 2015;11:571-6 pubmed publisher
    ..These results suggested that ATG2B may be a new potential therapeutic target for NSCLC. Furthermore, it was implied that interrupting autophagy and glycolysis improves NSCLC therapy. ..
  46. Dong Z, Ren L, Lin L, Li J, Huang Y, Li J. Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells. Mol Med Rep. 2015;11:682-90 pubmed publisher
    ..in carcinogenesis; however, none of these studies has investigated multidrug resistance (MDR) reversal in human lung cancer cells...
  47. Wang Y, Bu F, Royer C, Serres S, Larkin J, Soto M, et al. ASPP2 controls epithelial plasticity and inhibits metastasis through ?-catenin-dependent regulation of ZEB1. Nat Cell Biol. 2014;16:1092-104 pubmed publisher
    ..Hence, ASPP2 is a key regulator of epithelial plasticity that connects cell polarity to the suppression of WNT signalling, EMT and tumour metastasis...
  48. López Mejías R, Ubilla B, Genre F, Corrales A, Hernandez J, Ferraz Amaro I, et al. Osteoprotegerin concentrations relate independently to established cardiovascular disease in rheumatoid arthritis. J Rheumatol. 2015;42:39-45 pubmed publisher
    ..04). OPG concentrations are associated with disease severity and CVD prevalence in patients with RA. Whether consideration of OPG concentrations can improve CVD risk stratification in RA merits future longitudinal investigation. ..
  49. Pang L, Li Q, Wei C, Zou H, Li S, Cao W, et al. TGF-?1/Smad signaling pathway regulates epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: in vitro and clinical analyses of cell lines and nomadic Kazakh patients from northwest Xinjiang, China. PLoS ONE. 2014;9:e112300 pubmed publisher
    ..The TGF-?1/Smad signaling pathway in human Eca109 ESCC cells may carry similar features as in Kazakh ESCC patients, suggesting that TGF-?1/Smad signaling ..
  50. Riveira Munoz E, Ruiz A, Pauls E, Permanyer M, Badia R, Mothe B, et al. Increased expression of SAMHD1 in a subset of HIV-1 elite controllers. J Antimicrob Chemother. 2014;69:3057-60 pubmed publisher
    ..Our results suggest that SAMHD1 may play a role in controlling virus replication in HIV+ individuals and slow the rate of disease progression. ..
  51. Jansen C, Eischeid H, Goertzen J, Schierwagen R, Anadol E, Strassburg C, et al. The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS. PLoS ONE. 2014;9:e103779 pubmed publisher
    ....
  52. Wang L, Xie P, Lin Y, Ma J, Li W. Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy. Med Sci Monit. 2014;20:1363-8 pubmed publisher
    ..0046). Our results indicate that PCDH10 methylation in prostate cancer tissue is an independent prognostic biomarker of worse BCR-free survival of patients with prostate cancer after radical prostatectomy. ..
  53. Dubois Pot Schneider H, Fekir K, Coulouarn C, Glaise D, Aninat C, Jarnouen K, et al. Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. Hepatology. 2014;60:2077-90 pubmed publisher
    b>Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance to therapies. Recent studies have reported that HCC may be derived not only from adult hepatocytes and hepatoblasts but also hepatic stem/progenitors...
  54. Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed publisher
    ..We now show that these processes require acetate-dependent acetyl CoA synthetase 2 (ACSS2). In human Hep3B hepatoma cells and in EPO-generating organs of hypoxic or acutely anemic mice, acetate levels rise and ACSS2 ..
  55. Desgrosellier J, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, et al. Integrin ?v?3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014;30:295-308 pubmed publisher
    ..In human breast cancer cells, ?v?3 was necessary and sufficient for Slug activation, tumorsphere formation, and tumor ..
  56. Umemura S, Mimaki S, Makinoshima H, Tada S, Ishii G, Ohmatsu H, et al. Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. J Thorac Oncol. 2014;9:1324-31 pubmed publisher
    ..The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. Therefore, a sequencing-based comprehensive analysis could stratify SCLC patients by potential therapeutic targets. ..
  57. Tadokoro T, Wang Y, Barak L, Bai Y, Randell S, Hogan B. IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. Proc Natl Acad Sci U S A. 2014;111:E3641-9 pubmed publisher
    ..secretory cells from basal cells. Gain-of-function and loss-of-function studies with cultured mouse and human basal cells suggest that IL-6/Stat3 signaling promotes ciliogenesis at multiple levels, including increases in ..
  58. Fuseya T, Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Mita T, et al. Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population. Cardiovasc Diabetol. 2014;13:126 pubmed publisher
    ..Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population. ..
  59. Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed publisher
    ..In this study, we demonstrated that miR-101 was mainly transcribed from human miR-101-2 and mouse miR-101bgene loci...
  60. Ordureau A, Sarraf S, Duda D, Heo J, Jedrychowski M, Sviderskiy V, et al. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell. 2014;56:360-75 pubmed publisher
    ....
  61. Brglez V, Lambeau G, Petan T. Secreted phospholipases A2 in cancer: diverse mechanisms of action. Biochimie. 2014;107 Pt A:114-23 pubmed publisher
    ..In this short review, we highlight the newest findings on the biological roles of sPLA2s in cancer, with emphasis on their diverse mechanisms of action. ..
  62. Antony P, Rose M, Heidenreich A, Knüchel R, Gaisa N, Dahl E. Epigenetic inactivation of ST6GAL1 in human bladder cancer. BMC Cancer. 2014;14:901 pubmed publisher
    ..This is the first study to describe ST6GAL1 expression and regulation in human bladder cancer...
  63. Lazar C, Mutsuddi M, Kimchi A, Zelinger L, Mizrahi Meissonnier L, Marks Ohana D, et al. Whole exome sequencing reveals GUCY2D as a major gene associated with cone and cone-rod dystrophy in Israel. Invest Ophthalmol Vis Sci. 2014;56:420-30 pubmed publisher
    ..We also conclude that WES permits more comprehensive and rapid analyses that can be followed by targeted screens of larger samples to delineate the genetic structure of retinal disease in unique population cohorts. ..
  64. Wu H, Jiang Z, Fan X, Wang T, Ke Xu -, Yan X, et al. Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer. Hum Pathol. 2014;45:1936-43 pubmed publisher
    ..However, GRIM-1 expression in human non-small cell lung cancer (NSCLC) and its potential interaction with another apoptosis-associated protein-glucose-..
  65. Feng Y, Liu J, Kang Y, He Y, Liang B, Yang P, et al. miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer. J Exp Clin Cancer Res. 2014;33:67 pubmed publisher
    ..Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis. The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN. ..
  66. Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, et al. MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer. Br J Cancer. 2014;111:1572-80 pubmed publisher
    ..miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients. ..
  67. Scuderi S, La Cognata V, Drago F, Cavallaro S, D Agata V. Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. Biomed Res Int. 2014;2014:690796 pubmed publisher
    ..Parkin deficiency has also been linked to other human pathologies, for example, sporadic Parkinson disease, Alzheimer disease, autism, and cancer...
  68. Gallego Iradi C, Bickford J, Khare S, Hall A, Nick J, Salmasinia D, et al. KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking. Neurobiol Dis. 2014;71:270-9 pubmed publisher
    ..In an effort to identify the molecular basis of this allelic form of SCA13, we first determined that human KCNC3(WT) and KCNC3(R420H) display disparate post-translational modifications, and the mutant protein has reduced ..
  69. Nakayama S, Sng N, Carretero J, Welner R, Hayashi Y, Yamamoto M, et al. ?-catenin contributes to lung tumor development induced by EGFR mutations. Cancer Res. 2014;74:5891-902 pubmed publisher
    ..These data suggest that ?-catenin plays an essential role in lung tumorigenesis and that targeting the ?-catenin pathway may provide novel strategies to prevent lung cancer development or overcome resistance to EGFR TKIs. ..
  70. Bharti S, Sommers J, Zhou J, Kaplan D, Spelbrink J, Mergny J, et al. DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase. J Biol Chem. 2014;289:29975-93 pubmed publisher
    Mitochondrial DNA deletions are prominent in human genetic disorders, cancer, and aging...
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    CDH13 is a novel tumor suppressor gene often inactivated by aberrant promoter methylation in human cancers...
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    ..In contrast to CBSs from lower organisms, human CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet), which binds to the regulatory domain and ..
  73. Han D, Chu Su Y, Chiang C, Tseng F, Tseng P, Chen C, et al. Serum myostatin is reduced in individuals with metabolic syndrome. PLoS ONE. 2014;9:e108230 pubmed publisher
    ..Lower serum myostatin independently associated with MetS, central obesity, low HDL-C, and high triglycerides after adjustment. Higher serum myostatin is associated with favorable metabolic profiles. ..
  74. Chapman N, Dupr D, Rainey J. The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochem Cell Biol. 2014;92:431-40 pubmed publisher
    ..AR or APJ) is a class A (rhodopsin-like) G-protein-coupled receptor with wide distribution throughout the human body...
  75. Munro J, Gorman J, Ma X, Zhou Z, Arthos J, Burton D, et al. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014;346:759-63 pubmed publisher
    ..The distinct properties of neutralization-sensitive and neutralization-resistant HIV-1 isolates support a dynamics-based mechanism of immune evasion and ligand recognition. ..
  76. Lin Y, Wang Y, Fu X, Ma J. Aberrant methylation of PCDH8 is a potential prognostic biomarker for patients with clear cell renal cell carcinoma. Med Sci Monit. 2014;20:2380-5 pubmed publisher
    ..It is often inactivated by aberrant promoter methylation in several human cancers, including clear cell renal cell carcinoma (CCRCC)...
  77. Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, et al. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014;159:1110-1125 pubmed publisher
    ..The findings reveal a disease-relevant lncRNA mechanism consisting of both direct coordinated protein recruitment and indirect regulation of transcription factors. ..
  78. Gusarova V, Alexa C, Na E, Stevis P, Xin Y, Bonner Weir S, et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014;159:691-6 pubmed publisher
    ..The findings that plasma triglyceride levels are reduced by Angptl8 deletion and increased following ANGPTL8 overexpression support the possibility that inhibition of ANGPTL8 represents a therapeutic strategy for hypertriglyceridemia...
  79. Dergunov A, Shabrova E, Dobretsov G. Cholesteryl ester diffusion, location and self-association constraints determine CETP activity with discoidal HDL: excimer probe study. Arch Biochem Biophys. 2014;564:211-8 pubmed publisher
    ....
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    ..RIP3 therefore holds both necroptosis and apoptosis in balance through a Ripoptosome-like platform. This work highlights a common mechanism unveiling RHIM-driven apoptosis by therapeutic or genetic perturbation of RIP3. ..
  81. Zhao J, Xing N. Identification of ?-synuclein as a stage-specific marker in bladder cancer by immunohistochemistry. Med Sci Monit. 2014;20:2550-5 pubmed publisher
    ..Our results demonstrate that SNCG is highly expressed in bladder cancer tissue and its expression is stage-specific, but it is not helpful for predicting outcome in bladder cancer patients. ..
  82. Spilka R, Ernst C, Bergler H, Rainer J, Flechsig S, Vogetseder A, et al. eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation. Cell Oncol (Dordr). 2014;37:253-67 pubmed publisher
    ..From our results we conclude that eIF3a expression may have a profound effect on the UBC phenotype and, in addition, may serve as a prognostic marker for low grade UBCs. ..
  83. Deakin N, Turner C. Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration. J Cell Biol. 2014;206:395-413 pubmed publisher
    ..Importantly, these data reveal a fundamental role for paxillin in coordinating MT acetylation-dependent cell polarization and migration in both normal and transformed cells...
  84. Rai V. The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations. Asian Pac J Cancer Prev. 2014;15:5853-60 pubmed
    ..63, p=0.0003; TT+CT vs CC (dominant model): OR=1.12, 95%CI=1.01-1.23, p=0.02). The present meta-analysis strongly suggested a significant association between the MTHFR C677T polymorphism and risk of breast cancer in Asian populations. ..
  85. Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, et al. Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer ce. J Biol Chem. 2014;289:25431-44 pubmed publisher
    ..These results indicate a crucial role for SMAR1 in restraining breast cancer cell migration and suggest the candidature of this scaffold matrix-associated region-binding protein as a tumor suppressor. ..
  86. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514:187-92 pubmed publisher
    ..Here we show that human monocytes, epithelial cells and keratinocytes undergo necrosis upon cytoplasmic delivery of LPS...
  87. Wang N, Wei H, Yin D, Lu Y, Zhang Y, Jiang D, et al. Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis in cervical cancer cells in vitro and in vivo. Int J Clin Exp Pathol. 2014;7:4016-23 pubmed
    ..In conclusion, the present study indicates anti-tumor effects of cyclin D1b in cervical cancer, suggesting that cyclin D1b may represent a potential therapeutic target for cervical cancer. ..
  88. Rizzo A, Salerno P, Bezsonova I, Korzhnev D. NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response. Biochemistry. 2014;53:5895-906 pubmed publisher
    ..to characterize the binding to ubiquitin and determine the structure of the type 4 UBZ domain (UBZ4) from human Rad18, which is a key ubiquitin ligase in the DNA damage tolerance pathway responsible for monoubiquitination of ..
  89. Antonarakis E, Lu C, Wang H, Luber B, Nakazawa M, Roeser J, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med. 2014;371:1028-38 pubmed publisher
    ..These findings require large-scale prospective validation. (Funded by the Prostate Cancer Foundation and others.). ..
  90. Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment J, et al. Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat Cell Biol. 2014;16:1016-26, 1-8 pubmed publisher
    ..the most toxic of all DNA lesions, with defects in the DNA-damage response to DSBs being associated with various human diseases...
  91. Loibl S, von Minckwitz G, Schneeweiss A, Paepke S, Lehmann A, Rezai M, et al. PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer. J Clin Oncol. 2014;32:3212-20 pubmed publisher
    ..This study investigated the association between PIK3CA genotype and pathologic complete response (pCR) rates in human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with either dual or single anti-HER2 ..
  92. Tsuchiya M, Nakajima Y, Hirata N, Morishita T, Kishimoto H, Kanda Y, et al. Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells. Biochem Biophys Res Commun. 2014;452:928-32 pubmed publisher
    ..From our results, we propose that inhibition of CSC properties may be one of the functions of CHIP as a suppressor of cancer progression. ..
  93. Cerhan J, Berndt S, Vijai J, Ghesquieres H, McKay J, Wang S, et al. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet. 2014;46:1233-8 pubmed publisher
    ..63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. ..
  94. Alexy T, Rooney K, Weber M, Gray W, Searles C. TNF-? alters the release and transfer of microparticle-encapsulated miRNAs from endothelial cells. Physiol Genomics. 2014;46:833-40 pubmed publisher
    ..Here, we examined TNF-?-induced release of MP-encapsulated miR-126, miR-21, and miR-155 from human aortic endothelial cells (ECs) and their transfer to recipient cells...
  95. Price A, Jacques D, McEwan W, Fletcher A, Essig S, Chin J, et al. Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathog. 2014;10:e1004459 pubmed publisher
    ..These results reveal that multiple ligands share an overlapping interface in HIV-1 capsid that is lost upon viral disassembly. ..
  96. Scherer M, Klingl S, Sevvana M, Otto V, Schilling E, Stump J, et al. Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions. PLoS Pathog. 2014;10:e1004512 pubmed publisher
    ..The herpesvirus human cytomegalovirus (HCMV) expresses the abundant immediate-early protein IE1 that colocalizes with PML-NBs and ..
  97. Lacerda A, Hartjes E, Brunetti C. LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS ONE. 2014;9:e103454 pubmed publisher
    ..Together these data provide insight into how mutations in LITAF cause CMT1C disease. ..
  98. Tsoi H, Yu A, Chen Z, Ng N, Chan A, Yuen L, et al. A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J Med Genet. 2014;51:590-5 pubmed publisher
    ..This study expands our understanding of the cause of autosomal-dominant SCAs, a group of heterogeneous congenital neurological conditions in humans, and unveils a link between the JNK stress pathway and cerebellar atrophy...
  99. Kaname T, Ki C, Niikawa N, Baillie G, Day J, Yamamura K, et al. Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis. Cell Signal. 2014;26:2446-59 pubmed publisher
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