mouse

Summary

Alias: house mouse, Mus musculus, LK3 transgenic mice, Mus sp. 129SV, nude mice, transgenic mice, Mus muscaris, mice C57BL/6xCBA/CaJ hybrid, Mus musculus Linnaeus, 1758

Top Publications

  1. Jais A, Einwallner E, Sharif O, Gossens K, Lu T, Soyal S, et al. Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell. 2014;158:25-40 pubmed publisher
    ..These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease. ..
  2. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
    ..mechanisms leading to production of interleukin-1? in rheumatoid arthritis is limited by the absence of suitable mouse models of the disease in which inflammasomes contribute to pathology...
  3. Shida Y, Rydz N, Stegner D, Brown C, Mewburn J, Sponagle K, et al. Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and ?2?1-mediated collagen binding in thrombus formation. Blood. 2014;124:1799-807 pubmed publisher
    ..However, the analysis of these aberrant VWF-collagen interactions has been limited. Here, we have developed mouse models of collagen-binding mutants and analyzed the function of the A3 domain using comprehensive in vitro and in ..
  4. Jermann P, Hoerner L, Burger L, Schübeler D. Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Proc Natl Acad Sci U S A. 2014;111:E3415-21 pubmed publisher
    ..We inserted 28 DNA elements at a defined chromosomal position in mouse embryonic stem cells and assessed their ability to promote H3K27me3 deposition...
  5. Insolera R, Bazzi H, Shao W, Anderson K, Shi S. Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014;17:1528-35 pubmed publisher
    ..Our findings define the functions of centrioles in anchoring RGPs in the VZ and ensuring their efficient mitoses, and reveal the robust adaptability of RGPs in the developing cortex. ..
  6. Terami N, Ogawa D, Tachibana H, Hatanaka T, Wada J, Nakatsuka A, et al. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS ONE. 2014;9:e100777 pubmed publisher
    ..In this study, to resolve these issues, we evaluated the effects of the SGLT2 inhibitor, dapagliflozin, using a mouse model of type 2 diabetes and cultured proximal tubular epithelial (mProx24) cells...
  7. Peng M, Xie J, Ucher A, Stavnezer J, Cantor S. Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014;33:1698-712 pubmed publisher
    ..Rescue by Msh2 loss was confirmed in Fancd2-null primary mouse cells...
  8. Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, et al. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. 2014;63:4172-85 pubmed publisher
    ..Inhibition of MPO may be a potential strategy for prevention and treatment of obesity and insulin resistance. ..
  9. Abraham J, Núñez Álvarez Y, Hettmer S, Carrió E, Chen H, Nishijo K, et al. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014;28:1578-91 pubmed publisher
    ..We used conditional genetic mouse models of aRMS to activate the pathognomonic Pax3:Foxo1 fusion oncogene and inactivate p53 in several stages of ..
  10. Rocha S, Schiller M, Jing D, Li H, Butz S, Vestweber D, et al. Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ Res. 2014;115:581-90 pubmed publisher
    ..Esm1 expression is induced by the vascular endothelial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina...

Detail Information

Publications133 found, 100 shown here

  1. Jais A, Einwallner E, Sharif O, Gossens K, Lu T, Soyal S, et al. Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell. 2014;158:25-40 pubmed publisher
    ..These findings identify HO-1 inhibition as a potential therapeutic strategy for metabolic disease. ..
  2. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
    ..mechanisms leading to production of interleukin-1? in rheumatoid arthritis is limited by the absence of suitable mouse models of the disease in which inflammasomes contribute to pathology...
  3. Shida Y, Rydz N, Stegner D, Brown C, Mewburn J, Sponagle K, et al. Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and ?2?1-mediated collagen binding in thrombus formation. Blood. 2014;124:1799-807 pubmed publisher
    ..However, the analysis of these aberrant VWF-collagen interactions has been limited. Here, we have developed mouse models of collagen-binding mutants and analyzed the function of the A3 domain using comprehensive in vitro and in ..
  4. Jermann P, Hoerner L, Burger L, Schübeler D. Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Proc Natl Acad Sci U S A. 2014;111:E3415-21 pubmed publisher
    ..We inserted 28 DNA elements at a defined chromosomal position in mouse embryonic stem cells and assessed their ability to promote H3K27me3 deposition...
  5. Insolera R, Bazzi H, Shao W, Anderson K, Shi S. Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014;17:1528-35 pubmed publisher
    ..Our findings define the functions of centrioles in anchoring RGPs in the VZ and ensuring their efficient mitoses, and reveal the robust adaptability of RGPs in the developing cortex. ..
  6. Terami N, Ogawa D, Tachibana H, Hatanaka T, Wada J, Nakatsuka A, et al. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS ONE. 2014;9:e100777 pubmed publisher
    ..In this study, to resolve these issues, we evaluated the effects of the SGLT2 inhibitor, dapagliflozin, using a mouse model of type 2 diabetes and cultured proximal tubular epithelial (mProx24) cells...
  7. Peng M, Xie J, Ucher A, Stavnezer J, Cantor S. Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014;33:1698-712 pubmed publisher
    ..Rescue by Msh2 loss was confirmed in Fancd2-null primary mouse cells...
  8. Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, et al. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. 2014;63:4172-85 pubmed publisher
    ..Inhibition of MPO may be a potential strategy for prevention and treatment of obesity and insulin resistance. ..
  9. Abraham J, Núñez Álvarez Y, Hettmer S, Carrió E, Chen H, Nishijo K, et al. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014;28:1578-91 pubmed publisher
    ..We used conditional genetic mouse models of aRMS to activate the pathognomonic Pax3:Foxo1 fusion oncogene and inactivate p53 in several stages of ..
  10. Rocha S, Schiller M, Jing D, Li H, Butz S, Vestweber D, et al. Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ Res. 2014;115:581-90 pubmed publisher
    ..Esm1 expression is induced by the vascular endothelial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina...
  11. Vinnikov I, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth L, et al. Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci. 2014;34:10659-74 pubmed publisher
    ..Our data demonstrate in vivo the crucial role of neuronal microRNAs in the control of energy homeostasis. ..
  12. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514:187-92 pubmed publisher
    ..Human caspase-4 and the mouse homologue caspase-11 (hereafter referred to as caspase-4/11) and also human caspase-5, directly bound to LPS and ..
  13. Oldfield A, Yang P, Conway A, Cinghu S, Freudenberg J, Yellaboina S, et al. Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors. Mol Cell. 2014;55:708-22 pubmed publisher
    ....
  14. Zieger M, Ahnelt P, Uhrin P. CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. PLoS ONE. 2014;9:e106562 pubmed publisher
    ..CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa...
  15. Molawi K, Wolf Y, Kandalla P, Favret J, Hagemeyer N, Frenzel K, et al. Progressive replacement of embryo-derived cardiac macrophages with age. J Exp Med. 2014;211:2151-8 pubmed publisher
    ..Together, our observations indicate that in the heart, embryo-derived cM? show declining self-renewal with age and are progressively substituted by monocyte-derived macrophages, even in the absence of inflammation. ..
  16. Eswarappa S, Potdar A, Koch W, Fan Y, Vasu K, Lindner D, et al. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Cell. 2014;157:1605-18 pubmed publisher
    ..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. ..
  17. Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, et al. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev. 2014;28:1592-603 pubmed publisher
    ..These data identify ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development. ..
  18. Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi N, et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014;514:380-4 pubmed publisher
    The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem cells...
  19. Chen C, Hehnly H, Yu Q, Farkas D, Zheng G, Redick S, et al. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol. 2014;24:2327-2334 pubmed publisher
    ..All Pcnt(-/-) mouse tissues and cells examined showed spindle misorientation...
  20. Wang Y, Lauer M, Anand S, Mack J, Maytin E. Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress. J Biol Chem. 2014;289:32253-65 pubmed publisher
    ..The exogenous addition of high molecular weight HA failed to reverse this effect. We conclude that Has1/3 null skin fibroblasts (which have higher levels of Has2 gene expression) are resistant to stress-induced apoptosis. ..
  21. He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, et al. The G protein ? subunit G?s is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med. 2014;20:1035-42 pubmed publisher
    ....
  22. Gustafson W, Meyerowitz J, Nekritz E, Chen J, Benes C, Charron E, et al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014;26:414-427 pubmed publisher
    ....
  23. Cheng S, Quintin J, Cramer R, Shepardson K, Saeed S, Kumar V, et al. mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345:1250684 pubmed publisher
    ..Our results indicate that induction of aerobic glycolysis through an Akt-mTOR-HIF-1? pathway represents the metabolic basis of trained immunity. ..
  24. Hildebrand J, Tanzer M, Lucet I, Young S, Spall S, Sharma P, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014;111:15072-7 pubmed publisher
    ..This inhibitor provides a novel tool to investigate necroptosis and demonstrates the feasibility of using small molecules to target the nucleotide binding site of pseudokinases to modulate signal transduction. ..
  25. Riising E, Comet I, Leblanc B, Wu X, Johansen J, Helin K. Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. Mol Cell. 2014;55:347-60 pubmed publisher
    ..that knockout of the Polycomb repressive complex 2 (PRC2) does not lead to significant gene expression changes in mouse embryonic stem cells (mESCs) and that it is dispensable for initiating silencing of target genes during ..
  26. Goubau D, Schlee M, Deddouche S, Pruijssers A, Zillinger T, Goldeck M, et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature. 2014;514:372-375 pubmed publisher
    ..Such RNAs are found in some viruses but not in uninfected cells, indicating that recognition of 5'pp-RNA, like that of 5'ppp-RNA, acts as a powerful means of self/non-self discrimination by the innate immune system. ..
  27. Gusarova V, Alexa C, Na E, Stevis P, Xin Y, Bonner Weir S, et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014;159:691-6 pubmed publisher
    ..The findings that plasma triglyceride levels are reduced by Angptl8 deletion and increased following ANGPTL8 overexpression support the possibility that inhibition of ANGPTL8 represents a therapeutic strategy for hypertriglyceridemia...
  28. Nguyen C, Kim E, Luong T, Pyo S, Rhee D. ATF3 confers resistance to pneumococcal infection through positive regulation of cytokine production. J Infect Dis. 2014;210:1745-54 pubmed publisher
    ..Taken together, we can conclude that ATF3 regulates innate immunity positively upon pneumococcus infection by enhancing TNF-?, IL-1?, and IFN-? expression and modulating bacterial clearance. ..
  29. Paul M, Bisht B, Darmawan D, Chiou R, Ha V, Wallace W, et al. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Cell Stem Cell. 2014;15:199-214 pubmed publisher
    ..Here, we show in mouse and human airway basal stem cells (ABSCs) that intracellular flux from low to moderate ROS levels is required for ..
  30. Boggs J, Homchaudhuri L, Ranagaraj G, Liu Y, Smith G, Harauz G. Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells. BMC Res Notes. 2014;7:387 pubmed publisher
    ..This study supports further a role for classic MBP isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in OLGs. ..
  31. Machicoane M, de Frutos C, Fink J, Rocancourt M, Lombardi Y, Garel S, et al. SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation. J Cell Biol. 2014;205:791-9 pubmed publisher
    ..Accordingly, impairing ERM activation in apical progenitors of the mouse embryonic neocortex severely disturbed spindle orientation in vivo...
  32. Tang Y, Gholamin S, Schubert S, Willardson M, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014;20:732-40 pubmed publisher
    ..Notably, patient- and GEMM (genetically engineered mouse model)-derived Hedgehog-driven tumors (basal cell carcinoma, medulloblastoma and atypical teratoid rhabdoid tumor) ..
  33. Yoshitaka T, Ishida S, Mukai T, Kittaka M, REICHENBERGER E, Ueki Y. Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-?-induced inflammation and bone loss. J Bone Miner Res. 2014;29:1170-82 pubmed publisher
    ..In a knock-in mouse model for cherubism, we previously demonstrated that homozygous mutant mice develop T/B cell-independent systemic ..
  34. Gaudette B, Iwakoshi N, Boise L. Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation. J Biol Chem. 2014;289:23629-40 pubmed publisher
    ..This cell death is C/EBP homologous protein (CHOP)-dependent, connecting these events to the UPR. Thus plasma cell differentiation proceeds through a Bcl-xL-dependent intermediate. ..
  35. Gautier E, Ivanov S, Williams J, Huang S, Marcelin G, Fairfax K, et al. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med. 2014;211:1525-31 pubmed publisher
    ..Thus, Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages. ..
  36. Ferrer M, Scharrig E, Alberdi L, Cédola M, Pretre G, Drut R, et al. Decay-accelerating factor 1 deficiency exacerbates leptospiral-induced murine chronic nephritis and renal fibrosis. PLoS ONE. 2014;9:e102860 pubmed publisher
    ..This study demonstrates the link between Leptospira-induced murine chronic nephritis with renal fibrosis and shows a protective role of Daf1. ..
  37. Pryor S, Massa V, Savery D, Andre P, Yang Y, Greene N, et al. Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development. 2014;141:3153-8 pubmed publisher
    ..Vangl2(Lp/Lp) mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure...
  38. Kir S, White J, Kleiner S, Kazak L, Cohen P, Baracos V, et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 2014;513:100-4 pubmed publisher
    ..Thus, neutralization of PTHrP might hold promise for ameliorating cancer cachexia and improving patient survival. ..
  39. Kishi Itakura C, Koyama Honda I, Itakura E, Mizushima N. Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells. J Cell Sci. 2014;127:4089-102 pubmed publisher
    ..Here, systematic ultrastructural analysis of mouse embryonic fibroblasts (MEFs) and HeLa cells deficient in various ATG proteins reveals that the emergence of the ..
  40. Lamming D, Mihaylova M, Katajisto P, Baar E, Yilmaz O, Hutchins A, et al. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 2014;13:911-7 pubmed publisher
    ..RICTOR is a protein component of mTORC2 that is essential for its activity. We examined three different mouse models of Rictor loss: mice heterozygous for Rictor, mice lacking hepatic Rictor, and mice in which Rictor was ..
  41. Pillidge K, Porter A, Dudley J, Tsai Y, Heal D, Stanford S. The behavioural response of mice lacking NK? receptors to guanfacine resembles its clinical profile in treatment of ADHD. Br J Pharmacol. 2014;171:4785-96 pubmed publisher
    ..This evidence that guanfacine improves attention at a dose that did not affect arousal or emotionality supports our proposal that NK1R-/- mice express an attention deficit resembling that of ADHD patients. ..
  42. Yang L, Tsang K, Tang H, Chan D, Cheah K. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci U S A. 2014;111:12097-102 pubmed publisher
    ....
  43. Perry J, Lio C, Kau A, Nutsch K, Yang Z, Gordon J, et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity. 2014;41:414-426 pubmed publisher
    ....
  44. Wang X, Chrysovergis K, Kosak J, Kissling G, Streicker M, Moser G, et al. hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. Aging (Albany NY). 2014;6:690-704 pubmed
    ..Collectively, hNAG-1 is an important regulator of mammalian longevity and may act as a survival factor. Our study suggests that hNAG-1 has potential therapeutic uses in obesity-related diseases where life span is frequently shorter. ..
  45. Tamarina N, Roe M, Philipson L. Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic ?-cells. Islets. 2014;6:e27685 pubmed publisher
    ..We report the generation of a transgenic mouse line that enables a highly specific system for conditional gene manipulation within ?-cells and achieve tissue ..
  46. Bao Y, Guo Y, Li Z, Fang W, Yang Y, Li X, et al. MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation. PLoS ONE. 2014;9:e99132 pubmed publisher
    ..These findings shed light on revealing the mechanisms of chronic colitis malignant transformation. ..
  47. Li B, Jie W, Huang L, Wei P, Li S, Luo Z, et al. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci. 2014;17:1055-63 pubmed publisher
    ....
  48. Zhou B, Yue R, Murphy M, Peyer J, Morrison S. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014;15:154-68 pubmed publisher
    ..LepR(+) cells were quiescent, but they proliferated after injury. Therefore, LepR(+) cells are the major source of bone and adipocytes in adult bone marrow. ..
  49. Rodgers M, Bowman J, Fujita H, Orazio N, Shi M, Liang Q, et al. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J Exp Med. 2014;211:1333-47 pubmed publisher
    ....
  50. Jurk D, Wilson C, Passos J, Oakley F, Correia Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;2:4172 pubmed publisher
    ..These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor...
  51. Thauvin Robinet C, Lee J, Lopez E, Herranz Pérez V, Shida T, Franco B, et al. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat Genet. 2014;46:905-11 pubmed publisher
    ..Our results identify regulation of centriole length as an emerging pathogenic mechanism in ciliopathies. ..
  52. Vargas K, Makani S, Davis T, Westphal C, Castillo P, Chandra S. Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci. 2014;34:9364-76 pubmed publisher
    ..Slowed endocytosis observed in synuclein null cultures can be rescued by individually expressing mouse ?-, ?-, or ?-synuclein, indicating they are functionally redundant...
  53. Hatori M, Gill S, Mure L, Goulding M, O Leary D, Panda S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. elife. 2014;3:e03357 pubmed publisher
    ..Therefore, by regulating expression of genes mediating intercellular communication, Lhx1 imparts synchrony among SCN neurons and ensures consolidated rhythms of activity and rest that is resistant to photic noise. ..
  54. Schneider J, Suh Y, Cuervo A. Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab. 2014;20:417-32 pubmed publisher
    ..In this work, we have generated a conditional knockout mouse to selectively block CMA in liver...
  55. Du W, Yang W, Fang L, Xuan J, Li H, Khorshidi A, et al. miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7. Cell Death Dis. 2014;5:e1355 pubmed publisher
    ..Thus, the oncogenic miR-17 also acts pleiotropically to inhibit cellular senescence and extend longevity. ..
  56. Nair Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, et al. TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. Cell. 2014;158:506-21 pubmed publisher
    ..Phospho-SNAP23 stabilizes SNARE complexes orchestrating ERC-phagosome fusion, enrichment of phagosomes with ERC-derived MHC-I, and subsequent cross-presentation during infection...
  57. Moffat C, Bhatia L, Nguyen T, LYNCH P, Wang M, Wang D, et al. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014;55:2458-70 pubmed publisher
    ..Using a model of adenoviral Acot2 overexpression in mouse liver (Ad-Acot2), we show that Acot2 increases the utilization of FA substrate during the daytime in ad libitum-..
  58. Yuen B, Bush K, Barrilleaux B, Cotterman R, Knoepfler P. Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014;141:3483-94 pubmed publisher
    ..Recently, we developed a knockout mouse model for the H3f3b gene, one of two genes encoding H3.3...
  59. Yousefzadeh M, Wyatt D, Takata K, Mu Y, Hensley S, Tomida J, et al. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014;10:e1004654 pubmed publisher
    ..Our findings depart from the prevailing view that alternative end joining processes are generically translocation-prone. ..
  60. Clouthier D, Zhou A, Watts T. Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC. J Immunol. 2014;193:5033-43 pubmed publisher
    ..These studies identify GITR as a promising therapeutic target for chronic infection. ..
  61. Rogoz K, Andersen H, Lagerstr m M, Kullander K. Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons. J Neurosci. 2014;34:14055-68 pubmed publisher
    ..Our study reveals how different neurotransmitters combined can cooperate with each other to transmit or regulate various acute sensations, including itch...
  62. Shan Y, Hsu H, Lai M, Yen M, Fang J, Weng T, et al. Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model. Oncol Rep. 2014;32:2335-42 pubmed publisher
    ..Furthermore, given the effects of MUC2 on IL-6 secretion, its targeting may represent a potentially useful strategy to treat colonic carcinomas. ..
  63. Hofmann U, Knörr S, Vogel B, Weirather J, Frey A, Ertl G, et al. Interleukin-13 deficiency aggravates healing and remodeling in male mice after experimental myocardial infarction. Circ Heart Fail. 2014;7:822-30 pubmed publisher
    ..Our data indicate that IL-13 regulates leukocyte recruitment and induces M2-like monocyte/macrophage differentiation, which modifies wound healing within the infarct zone. ..
  64. Abranches E, Guedes A, Moravec M, Maamar H, Svoboda P, Raj A, et al. Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency. Development. 2014;141:2770-9 pubmed publisher
    ..Here, we have used a novel fluorescent reporter to investigate the temporal dynamics of NANOG expression in mouse embryonic stem cells (mESCs), and to dissect the lineage potential of mESCs at different NANOG states...
  65. Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
    ..CX?CR1?MNPs from both mouse and human tissue produced more IL-23 and IL-1? than conventional CD103(+) dendritic cells (cDCs) and were more ..
  66. Lee J, Jin H, Park M, Kim B, Lee P, Nakauchi H, et al. Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. J Exp Med. 2014;211:1551-70 pubmed publisher
    ..Partial genetic inhibition of ASM (ASM(+/-)) in a mouse model of familial AD (FAD; amyloid precursor protein [APP]/presenilin 1 [PS1]) ameliorated the autophagocytic ..
  67. DeBosch B, Kluth O, Fujiwara H, Schurmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642 pubmed publisher
    ..Moreover, these findings suggest that enterocytes may regulate whole-body metabolism, and that enterocyte urate metabolism could potentially be targeted to modulate or prevent metabolic syndrome. ..
  68. Nakayama S, Sng N, Carretero J, Welner R, Hayashi Y, Yamamoto M, et al. ?-catenin contributes to lung tumor development induced by EGFR mutations. Cancer Res. 2014;74:5891-902 pubmed publisher
    ..and genetic deletion of the ?-catenin gene dramatically reduced lung tumor formation in EGFR-L858R-T790M transgenic mice. These data suggest that ?-catenin plays an essential role in lung tumorigenesis and that targeting the ?-..
  69. Platt R, Chen S, Zhou Y, Yim M, Swiech L, Kempton H, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014;159:440-55 pubmed publisher
    ..To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, lentivirus-, or ..
  70. Leontieva O, Paszkiewicz G, Blagosklonny M. Fasting levels of hepatic p-S6 are increased in old mice. Cell Cycle. 2014;13:2656-9 pubmed publisher
    ..In contrast, rapamycin is known to be effective, even when started late in life. ..
  71. Farin H, Karthaus W, Kujala P, Rakhshandehroo M, Schwank G, Vries R, et al. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-?. J Exp Med. 2014;211:1393-405 pubmed publisher
    ..The identification of IFN-? as a trigger for degranulation and extrusion of PCs establishes a novel effector mechanism by which immune responses may regulate epithelial status and the gut microbiome. ..
  72. Preitner N, Quan J, Nowakowski D, Hancock M, Shi J, Tcherkezian J, et al. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell. 2014;158:368-382 pubmed publisher
    ..These results identify APC as a platform binding functionally related protein and RNA networks, and suggest a self-organizing model for the microtubule to localize synthesis of its own subunits...
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    ..These findings indicate that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits. ..
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    ..Further studies are required to confirm these results using animal models in which retinal D2R is selectively blocked. ..
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    ..Furthermore, IL-1?-induced TH9 cells exerted potent anticancer functions in an IRF1- and IL-21-dependent manner. Our findings thus identify IRF1 as a target for controlling the function of TH9 cells. ..
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    ....
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    ..Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected ..
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    ..Here we investigate the role of TFEB in AD mouse models...
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    ..First, we found that SENP1 levels increased after I/R in human and mouse myocardium in vivo and in rat cardiomyocytes in vitro...
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    ..Our results reveal cellular components of a retinal circuit and demonstrate roles of type II cadherins in synaptic choice and circuit function. ..
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    ..Thus, NgR1 functions with PV interneurons to limit plasticity of binocularity, but its expression is required more extensively within brain circuitry to limit improvement of visual acuity following chronic deprivation. ..
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    ..We generated a p63-CreERT2 knock-in mouse line that expresses tamoxifen-inducible Cre activity in the p63-expressing cells, including the prostate BCs...
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    ..Lack of selective pressure by bacterial infections might explain the evolutionary loss of TLR13 in humans. However, further studies using different bacterial species are needed to prove this hypothesis. ..
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    ..Additionally, this work supports the strategy of exploring HIF1? as a therapeutic target in specific immunosuppressed populations with fungal infections. ..
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    ..These findings suggest that SPAG6 not only regulates cilia/flagellar motility, but that in its absence, ciliogenesis, axoneme orientation, and tracheal epithelial cell polarity are altered. ..
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    ..To decipher Olig2 functions, we generated transgenic mice (TetOlig2:Sox10(rtTA/+)) overexpressing Olig2 in Sox10(+) oligodendroglial cells in a doxycycline inducible ..
  98. Ritter M, Straubinger K, Schmidt S, Busch D, Hagner S, Garn H, et al. Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1? during acute allergic airway inflammation. Clin Exp Immunol. 2014;178:212-23 pubmed publisher
    ..Amelioration of asthmatic symptoms was only observed when anakinra was administered during OVA challenge. Our findings indicate that blocking IL-1 signalling could be a potential complementary therapy for allergic airway inflammation. ..
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    ..The results suggest that shRNA-mediated knockdown can produce untoward migration effects by altering endogenous miRNA pathways. ..
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    ..Thus, by supporting fast glutamatergic transmission as well as by modulating the strength of cholinergic signaling, VGLUT3 has the capacity to exert widespread influence on the striatal network. ..