Alias: Norway rat, rats, brown rat, Rattus norvegicus, Rattus sp. strain Wistar, laboratory rat, Wistar rats, Sprague-Dawley rat, Buffalo rat, Rattus PC12 clone IS, zitter rats, Rattus rattiscus, Gunn rats, Rattus norwegicus, Rattus norvegicus8

Top Publications

  1. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
  2. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
  3. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
  4. ncbi Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nature 423:762-9. 2003
  5. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
  6. pmc LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    Y Kabeya
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
    EMBO J 19:5720-8. 2000
  7. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
  8. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
  9. ncbi Calcium signaling
    David E Clapham
    Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 131:1047-58. 2007
  10. ncbi RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
    Nature 382:685-91. 1996

Detail Information

Publications382 found, 100 shown here

  1. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
    ..kisspeptins on gonadotropin secretion, we injected kisspeptin-52 into the lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p < 0.05)...
  2. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  3. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
    ..These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T...
  4. ncbi Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nature 423:762-9. 2003
  5. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol...
  6. pmc LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    Y Kabeya
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
    EMBO J 19:5720-8. 2000
    ..Here we demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is ..
  7. ncbi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Paola Scaffidi
    DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
    Nature 418:191-5. 2002
    ..Thus, cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma...
  8. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
    ..Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation...
  9. ncbi Calcium signaling
    David E Clapham
    Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 131:1047-58. 2007
    ..Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription...
  10. ncbi RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
    Nature 382:685-91. 1996
    ..Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death...
  11. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  12. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  13. ncbi International union of pharmacology. XXIII. The angiotensin II receptors
    M De Gasparo
    Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
    Pharmacol Rev 52:415-72. 2000
    ..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system...
  14. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
  15. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  16. pmc Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    Nicolas de Roux
    Institut National de la Santé et de la Recherche Médicale Unité 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, 94275 Le Kremlin Bicetre, France
    Proc Natl Acad Sci U S A 100:10972-6. 2003
    ..The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis...
  17. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  18. ncbi Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    H Cho
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 292:1728-31. 2001
    ..These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis...
  19. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
  20. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models...
  21. doi The widespread regulation of microRNA biogenesis, function and decay
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 11:597-610. 2010
    ..Such regulation has an important role in the context-specific functions of miRNAs...
  22. ncbi Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    Yigong Shi
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Cell 113:685-700. 2003
    ..This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus...
  23. ncbi Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    M Kuro-O
    Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Nature 390:45-51. 1997
    ..The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases...
  24. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
  25. ncbi Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    T Nakagawa
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:98-103. 2000
    ..Thus, caspase-12 mediates an ER-specific apoptosis pathway and may contribute to amyloid-beta neurotoxicity...
  26. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
  27. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    ..Long-range conformational changes couple these functions via allosteric equilibria...
  28. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
    ..When administered centrally to rats, these peptides stimulate food consumption...
  29. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with ..
  30. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  31. ncbi Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    D A Cross
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
    Nature 378:785-9. 1995
    ..Like the inhibition of GSK3 (refs 10, 14), the activation of PKB is prevented by inhibitors of phosphatidylinositol (PI) 3-kinase...
  32. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..Soluble Abeta from Alzheimer's disease brain also disrupted the memory of a learned behavior in normal rats. These various effects were specifically attributable to Abeta dimers...
  33. pmc TLR4 links innate immunity and fatty acid-induced insulin resistance
    Hang Shi
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:3015-25. 2006
  34. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
    ..By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and ..
  35. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  36. ncbi A serum shock induces circadian gene expression in mammalian tissue culture cells
    A Balsalobre
    Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, Switzerland
    Cell 93:929-37. 1998
    The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals...
  37. pmc Lasting epigenetic influence of early-life adversity on the BDNF gene
    Tania L Roth
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    Biol Psychiatry 65:760-9. 2009
    Childhood maltreatment and early trauma leave lasting imprints on neural mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic ..
  38. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
    The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain...
  39. pmc A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    J D Molkentin
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, 75225 9148, USA
    Cell 93:215-28. 1998
    ..Pharmacologic inhibition of calcineurin activity blocks hypertrophy in vivo and in vitro. These results define a novel hypertrophic signaling pathway and suggest pharmacologic approaches to prevent cardiac hypertrophy and heart failure...
  40. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  41. pmc Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    Hsiuchen Chen
    Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
    J Cell Biol 160:189-200. 2003
    ..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...
  42. pmc An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling
    Soren Impey
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA
    Mol Cell Neurosci 43:146-56. 2010
    ..These data suggest that neuronal activity regulates spine formation, in part, by increasing miR132 transcription, which in turn activates a Rac1-Pak actin remodeling pathway...
  43. pmc Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
    Krishna M Vattem
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 101:11269-74. 2004
    ..These results suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to mammals...
  44. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
    ..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology...
  45. pmc SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    David C Schultz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:919-32. 2002
    ..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression...
  46. pmc Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins
    Ethan R Graf
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:1013-26. 2004
  47. ncbi Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    Thomas J Lynch
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    N Engl J Med 350:2129-39. 2004
    ..However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms underlying sensitivity to gefitinib are unknown...
  48. ncbi The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    Jeffrey A Engelman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Genet 7:606-19. 2006
    ..In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases...
  49. ncbi Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    F Urano
    Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology and the Kaplan Cancer Center, New York University Medical School, New York, NY 10016, USA
    Science 287:664-6. 2000
    ..Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals...
  50. ncbi Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    D R Rosen
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown 02129
    Nature 362:59-62. 1993
    ..Given this linkage and the potential role of free radical toxicity in other neurodenegerative disorders, we investigated SOD1 as a candidate gene in FALS. We identified 11 different SOD1 missense mutations in 13 different FALS families...
  51. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival...
  52. pmc Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    Cardiovasc Res 87:431-9. 2010
    The aims of the present study are to determine the miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in IP-mediated cardiac protection, and the potential cellular ..
  53. pmc Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    Wesley Farris
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4162-7. 2003
    ..region containing a mutant IDE allele has been associated with hyperinsulinemia and glucose intolerance in a rat model of DM2. Human genetic studies have implicated the IDE region of chromosome 10 in both AD and DM2...
  54. ncbi A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
    Atsushi Kamiya
    Department of Psychiatry Neurobiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 117, Baltimore, MD 21287, USA
    Nat Cell Biol 7:1167-78. 2005
    ..These results indicate that DISC1 is involved in cerebral cortex development, and suggest that loss of DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia...
  55. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
    ..Blocking this microglia-neuron signalling pathway may represent a therapeutic strategy for treating neuropathic pain...
  56. pmc Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
    Zhaolan Zhou
    Neurobiology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 52:255-69. 2006
  57. pmc Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
    Akiko Hayashi-Takagi
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:327-32. 2010
    ..the duration and intensity of Rac1 activation in response to NMDA receptor activation in both cortical cultures and rat brain in vivo...
  58. ncbi Two genes encode distinct glutamate decarboxylases
    M G Erlander
    Neuroscience Program, University of California Los Angeles 90024
    Neuron 7:91-100. 1991
    ..The distinctive properties of the two GADs provide a substrate for understanding not only the multiple roles of GABA in the nervous system, but also the autoimmune response to GAD in insulin-dependent diabetes mellitus...
  59. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  60. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
    ..Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain...
  61. ncbi Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    N G Larsson
    Department of Molecular Medicine, Center for Molecular Medicine L8 02, Stockholm, Sweden
    Nat Genet 18:231-6. 1998
    ..5. Thus, Tfam is the first mammalian protein demonstrated to regulate mtDNA copy number in vivo and is essential for mitochondrial biogenesis and embryonic development...
  62. pmc Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2
    Ha Won Kim
    Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 284:33161-8. 2009
    ..Extrapolation of these data to in vivo studies in a rat model of acute myocardial infarction predominantly improved stem cell survival after engraftment with a role for ..
  63. ncbi Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    H Monyer
    Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
    Neuron 12:529-40. 1994
    An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts display distinct expression patterns...
  64. ncbi The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54
    M Kotani
    Institut de Recherche Interdisciplinare en Biologie Humaine et Nucléaire I R I B H N, Brussels, Belgium
    J Biol Chem 276:34631-6. 2001
    ..Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis.
  65. ncbi The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    Y Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:652-6. 2001
    ..We propose that the Cdc48/p97-Ufd1-Npl4 complex extracts proteins from the ER membrane for cytosolic degradation...
  66. ncbi The kinase domain of titin controls muscle gene expression and protein turnover
    Stephan Lange
    Muscle Signalling and Development, Randall Division, King s College London, London SE1 1UL, UK
    Science 308:1599-603. 2005
    ..A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway...
  67. pmc Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
    Jesus F Bermejo-Martin
    National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
    Crit Care 13:R201. 2009
    ..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
  68. ncbi Neuropilin is a semaphorin III receptor
    A L Kolodkin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cell 90:753-62. 1997
    ..We also describe the identification of neuropilin-2, a related neuropilin family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system.
  69. ncbi RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    D M Sabatini
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell 78:35-43. 1994
    ..We propose that RAFT1 is the direct target of FKBP12-rapamycin and a mammalian homolog of the TOR proteins...
  70. ncbi Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    M H Polymeropoulos
    Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Science 276:2045-7. 1997
    ..This finding of a specific molecular alteration associated with PD will facilitate the detailed understanding of the pathophysiology of the disorder...
  71. ncbi Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
    ..Altogether, these observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness...
  72. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  73. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
    ..Thus, GSK-3beta facilitates NF-kappaB function...
  74. pmc Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
    Cagla Eroglu
    Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
    Cell 139:380-92. 2009
    ..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
  75. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
  76. ncbi Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    J C Tu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:717-26. 1998
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function...
  77. ncbi Homer: a protein that selectively binds metabotropic glutamate receptors
    P R Brakeman
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 386:284-8. 1997
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling...
  78. ncbi LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..In rat hippocampal slices, GSK3beta inhibitors block the induction of LTD...
  79. ncbi Subunit arrangement and function in NMDA receptors
    Hiroyasu Furukawa
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 438:185-92. 2005
  80. ncbi Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
    R B Sutton
    The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 395:347-53. 1998
    ..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission...
  81. doi Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:342-7. 2009
    ..2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls)...
  82. doi Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
    Hyun Ju Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 298:F662-71. 2010
    ..Subgroups of male Sprague-Dawley rats were subjected to 5/6 nephrectomy or sham operation and observed for 6 or 12 wk...
  83. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
    ..We now report that Keap1 also controls the total cellular level of Nrf2 protein. In the RL34 non-transformed rat liver cell line, Nrf2 was found to accumulate rapidly in response to oxidative stress caused by treatment with ..
  84. pmc A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
    Xiuli Zhao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:1024-31. 2013
    ..named Kcna2 antisense RNA, for a voltage-dependent potassium channel mRNA, Kcna2, in first-order sensory neurons of rat dorsal root ganglion (DRG)...
  85. ncbi TGF-beta signal transduction
    J Massague
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 67:753-91. 1998
    ..Mutations in these pathways are the cause of various forms of human cancer and developmental disorders...
  86. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
  87. ncbi Human hypertension caused by mutations in WNK kinases
    F H Wilson
    Howard Hughes Medical Institute Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510 USA
    Science 293:1107-12. 2001
    ..WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs...
  88. pmc Transforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathways
    Hsi Lung Hsieh
    Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Tao Yuan, Taiwan
    J Neuroinflammation 7:88. 2010
    ..Both TGF-β and MMPs have been shown to play crucial roles in brain pathological changes. Thus, we investigated the molecular mechanisms underlying TGF-β1-induced MMP-9 expression in brain astrocytes...
  89. ncbi A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    X Cao
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
    Science 293:115-20. 2001
    ..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
  90. ncbi Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    R Sherrington
    Department of Medicine Neurology, University of Toronto, Ontario, Canada
    Nature 375:754-60. 1995
    ..Because these changes occurred in conserved domains of this gene, and are not present in normal controls, they are likely to be causative of AD3...
  91. pmc ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
    Hideki Nishitoh
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku 113 8549, Japan
    Genes Dev 16:1345-55. 2002
    ..These findings suggest that ASK1 is a key element in ER stress-induced cell death that plays an important role in the neuropathological alterations in polyQ diseases...
  92. ncbi Identification and characterization of the vesicular GABA transporter
    S L McIntire
    Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
    Nature 389:870-6. 1997
    ..Further, a rat homologue of unc-47 is expressed by central GABA neurons and confers vesicular GABA transport in transfected cells ..
  93. pmc Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition
    Deepika Suri
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
    Biol Psychiatry 73:658-66. 2013
    ..While early life stress evokes persistent changes in anxiety, it is unknown whether early stress differentially regulates hippocampal neurogenesis, trophic factor expression, and cognition across the life span...
  94. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
    ..Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and dose-dependent manner, blocked by ..
  95. doi miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
    Rudy F Duisters
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Circ Res 104:170-8, 6p following 178. 2009
  96. ncbi Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
    Won K Han
    Medical Services, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Kidney Int 62:237-44. 2002
    ..and mucin domain, whose expression is markedly up-regulated in the proximal tubule in the post-ischemic rat kidney. The ectodomain of KIM-1 is shed from cells...
  97. pmc Translational control of C/EBPalpha and C/EBPbeta isoform expression
    C F Calkhoven
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 14:1920-32. 2000
    ..Our results demonstrate that the translational controlled ratio of C/EBPalpha and C/EBPbeta isoform expression determines cell fate...
  98. pmc Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis
    Filip A Konopacki
    Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 108:19772-7. 2011
    ..Thus, direct phosphorylation by PKC and GluK2 SUMOylation are intimately linked in regulating the surface expression and function of GluK2-containing KARs...
  99. pmc Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    Yuekui Li
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosci 23:1605-11. 2003
  100. ncbi S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
    Makoto R Hara
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 7:665-74. 2005
    ..The NO-S-nitrosylation-GAPDH-Siah1 cascade may represent an important molecular mechanism of cytotoxicity...
  101. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
    ..Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence...

Research Grants145 found, 100 shown here

  1. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..This protection occurs only in female but not in male rats. Preliminary studies have shown that neuroprotection is associated with increased late phase inhibition in the ..
  2. Aging Oxidative Stress and Microglia
    Paula C Bickford; Fiscal Year: 2013
    ..inflammation in the cerebellum by infusing TNF1 disrupts cerebellar synaptic plasticity (motor learning) in young rats while blocking TNF1 in aged rats modestly improves motor learning...
  3. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2013
    ..Specific metabolites will be tested for their ability to bind to rat and human TR11 and TR21 isoforms...
  4. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ..In Specific Aim 1, young adult male Wistar rats will be exposed to one of several conditions of social defeat stress (Nondefeat Control, 3x, 6x, or 9x defeat ..
  5. Remote effects of focal hippocampal seizures on neocortical function
    Hal Blumenfeld; Fiscal Year: 2013
    ..In support of this, we recently found in a rat model that spontaneous and induced limbic seizures exhibit high frequency discharges in the hippocampus, but slow 1-..
    William J McBride; Fiscal Year: 2013
    ..within the limbic system, selected experiments will be conducted with alcohol-preferring (P) rats and stock Wistar rats. The results of this project will provide important information on (a) CNS sites and receptors mediating the ..
  7. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ..Three experimental models of epilepsy will be used in Wistar rats. The first two models use 3-mercaptopropionic acid (3-MPA) to chemically induce seizures in a controlled manner...
  8. Role of the CNS in Inappropriate Vasopressin Release Associated with Cirrhosis
    JOSEPH D WALCH; Fiscal Year: 2013
    ..role of renin-angiotensin system in supporting the chronic activation of vasopressin neurons in bile duct ligated rats. 2: Test the hypothesis that increased expression of ?FosB produces cellular adaptations that contribute to ..
  9. Neuroendocrine Control of Glucose Metabolism
    Gregory J Morton; Fiscal Year: 2013
    ..suggests that induction of hyperleptinemia fully ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats and our recent findings implicate the brain in this effect...
    John F Disterhoft; Fiscal Year: 2013
    ..We have recently shown that the learning-related AHP reduction in young adult rats is mediated in part by protein kinase A (PKA) activity, known to activate CREB and subsequent gene transcription/..
  11. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..Previous animal models have infected rabbits, rats and mice with different viruses...
  12. The Role of Local BDNF Synthesis in Spine Morphogenesis
    LAUREN LYNN OREFICE; Fiscal Year: 2012
    ..In this assay, actin-GFP-labeled spines of cultured rat hippocampal neurons form during the first 2 weeks, mature during weeks 3 and 4, and are pruned during week 4...
  13. Neurobiological Correlates of Stress and Norepinephrine Transporter
    Meng Yang Zhu; Fiscal Year: 2012
    ..Similar results are also found in rats and cultured cells, which were treated with or exposed to stress-relevant doses of corticosterone...
  14. Nicotinic receptors: Role in hippocampal synaptic function
    Edson X Albuquerque; Fiscal Year: 2012
    ..Reduced activity of these nAChRs impairs cognition in rats and mice, and has been proposed to contribute to the cognitive deficits observed in patients with schizophrenia and ..
  15. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..Pretreatment with tacrine can produce long-lasting reductions in cocaine-reinforced behavior in rats, described as persistent attenuation (cocaine self-administration is decreased by more than 80% over a period of ..
  16. Prefrontal-Amygdala Interactions in Fear Conditioning
    Gregory J Quirk; Fiscal Year: 2012
    ..this grant show that the infralimbic prefrontal cortex (IL) plays a key role in the consolidation of extinction in rats. Neurons in IL exhibit NMDA receptor-dependent bursting immediately after extinction, and this bursting is ..
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    ..We will also examine the mechanisms for improved cognitive performance in rats after long-term exposure to recurrent hypoglycemia using MR spectroscopy as well as genomic and proteomic analyses...
  18. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..Activation of AMPK results in an increase in food intake. Ovariectomized female rats (lacking estradiol) become obese and have increased expression of hypothalamic pAMPK;however, the mechanism by ..
  19. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
    ..is aimed at understanding the network mechanisms that accompany place field representations in adult and ASMI rats that may be modulated via pharmacological and genetic methods to enhance cognitive performance...
  20. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..video-electroencephalographic (video-EEC), and learning and memory analyses in young adult F344 rats undergoing intraperitoneal kainic acid induced acute seizures and hippocampal injury, a model of temporal lobe ..
  21. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2013
    ..locus coeruleus (LC) neurons via glutamatergic signaling and that the anti-hypersensitivity effects of GBP in rats with peripheral nerve injury relies on this activation and subsequent spinal NA release...
  22. Opposing Effects of Chronic Stress on Amygdala and Hippocampus
    Ki Ann Goosens; Fiscal Year: 2013
    ..cutting-edge molecular methods (viral-mediated gene transfer) with immunohistochemical and behavioral techniques in rats to further examine this hypothesis and explore two mechanisms by which opposing effects may occur...
  23. Stress, Depression, Serotonin, and Plasticity of Excitatory Transmission
    Scott M Thompson; Fiscal Year: 2013
    ..The effects of 5-HT1B receptor activation on TA-CA1 synaptic transmission are enhanced in rats subjected to chronic unpredictable stress (CUS), an accepted animal model of depression, and blocked by chronic ..
  24. Icariin to Prevent Corticosteroid-Related Memory Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..Icariin, a flavonoid from Epimedium, 1) blocks the effects of corticosteroid-induced apoptosis in primary cultured rat hippocampal neurons, 2) is neuroprotective in animal models of ischemia, 3) improves memory in animal models of ..
  25. The role of astrocytes in memory consolidation
    Virginia Gao; Fiscal Year: 2013
    ..Blocking glycogenolysis in the rat hippocampus impairs memory...
  26. Metabolic syndrome and hippocampal Ca2+ dysregulation in aging memory decline
    Olivier Thibault; Fiscal Year: 2013
    ..Specific Aim # 1 will study F344 male rats fed a normal diet and determine, at 7-8 and 18-20 months of age, which component of metabolic dysregulation most ..
  27. Short-term estradiol use in middle-age: implications for female cognitive aging
    Jill M Daniel; Fiscal Year: 2013
    ..receptors, ER[unreadable], or both on the ability of short-term estradiol exposure in middle-aged ovariectomized rats to exert lasting impacts on ER[unreadable] target genes and associated proteins in the hippocampus and on ..
  28. Estradiol and Hippocampal Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..The goal of this proposal is to explore the novel observation of higher rates of cell genesis in the neonatal male rat hippocampus compared to the female, and an increase in cell genesis by exogenous estradiol treatment...
  29. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    ..in NMDA receptor function contribute to changes in the osmotic and non-osmotic regulation of vasopressin neurons in rats with experimental induced hepatic cirrhosis...
    Daniel Johnston; Fiscal Year: 2013
    ..the HCN1 subunit for h channels in dorsal hippocampus produces anti-depression and anti-anxiety like behaviors in rats. From the clinical literature there appears to be a strong co-morbidity for depression and anxiety in epilepsy...
  31. Electrophysiological ensembles organization during alcohol cue-induced intake and
    ..P rats) and in a rat population with average genetic susceptibility to excessive alcohol consumption (Wistar rats)...
  32. Muscarinic Receptor Induced LTD in Rat Hippocampus
    LORI LYNN MCMAHON; Fiscal Year: 2013
    JEROME NONE ENGEL; Fiscal Year: 2013
    ..We now have acquired evidence from several chronic rat models of human mesial temporal lobe epilepsy (MTLE), and from patients with MTLE, suggesting that pHFOs are ..
  34. Interaction of BPA and soy isoflavones on sociosexual behavior
    Heather B Patisaul; Fiscal Year: 2013
    ..Preliminary data from this laboratory reveal that many of these adverse behavioral effects do not manifest in Wistar rats maintained on a soy-rich diet, suggesting that soy isoflavones, such as genistein (GEN) have potentially ..
  35. Internal Dynamics of the Postsynaptic Density
    Thomas A Blanpied; Fiscal Year: 2013
    ..In cultured neurons from rat hippocampus, we will use quantitative fluorescence microscopy along with patch-clamp electrophysiology, photolysis, ..
    Michael K Georgieff; Fiscal Year: 2013
    ..We propose to perform studies in iron deficient anemic rat pups and 2 genetic mouse models of ID...
  37. Mechanisms of Metabolic Dysfunction in Type 2 Diabetes
    Robert W Wiseman; Fiscal Year: 2013
    ..Data will be obtained from male Wistar rats (normoglycemic) and the Goto Kakizaki rat model of T2D (hyperglycemic) to identify functional differences ..
  38. CRCNS: Path Intergration by the Grid Cell Network
    Kechen Zhang; Fiscal Year: 2013
    ..In rats, one particular kind of oscillation referred to as "theta rhythm" is very predominant in the hippocampus and ..
  39. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..We will employ a model of chronic epilepsy that develops in male Wistar rats following pilocarpine - induced status epilepticus (SE)...
  40. The role of GLT1 in the modulation of alcohol-drinking behavior in P rats.
    Youssef Sari; Fiscal Year: 2013
    ..We will also investigate the effects of GLT1 activation in EtOH-drinking behavior in Wistar rats as comparison control groups...
  41. Role of Endoplasmic Reticulum Stress in Obesity-Related Endothelial Dysfunction
    CHRISTOPHER GENTILE; Fiscal Year: 2013
    ..Aim 2 will examine if a high saturated fat diet induces ER stress in the vasculature of male Wistar rats, and if so, whether this ER stress mediates endothelial dysfunction that results from such a diet...
  42. MeCP2 regulation on LINE-1 retrotransposition in neurons
    Charles A Thomas; Fiscal Year: 2013
    ..gametogenesis and in neoplastic processes, but recent studies have shown L1s are extremely active in the mouse, rat, and human neuronal progenitor cells (NPCs)...
    John F Disterhoft; Fiscal Year: 2013
    ..The basic strategy of the proposed research is to diagnose aged rats as either impaired or unimpaired using two hippocampus-dependent tasks, and then examine the morphology, receptor ..
  44. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2009
    ..Six weeks prior to aerosol exposure, emphysema will be induced in Wistar rats by intratracheal instillation of pancreatic elastase...
  45. Anti-Aging Mitochondrial Protein Therapy for Alzheimer?s Disease and Sarcopenia
    JAMES PEPPER BENNETT; Fiscal Year: 2010
    ..pre- clinical Investigational New Drug (IND)studies for the FDA/CDER (Center for Drug Evaluation and Research): (i) Rat CNS (Irwin study), respiratory, dose range finding, and repeat dose 1 month;(ii) Dog cardiovascular, dose range ..
  46. Pro-inflammatory glucocorticoid effects in the CNS
    Robert M Sapolsky; Fiscal Year: 2010
    ..In all experiments, intact rats will be exposed to either LPS, a bacteria-derived molecule which stimulates a robust inflammatory response, or a ..
  47. Na/Bicarbonate Cotransporters in Brain
    MARK OLIVER BEVENSEE; Fiscal Year: 2010
    ..a-H exchangers (NHEs)) in cult ured astroc)'tes and neurons from rat hippocampus (Aim I). Int racellular P I P ~ levels will be altered in cells by di rect perfusion...
  48. Emotional learning-induced changes of neuronal representations in the hippocampal
    Almira Vazdarjanova; Fiscal Year: 2010
    ..inactivating the BLA before contextual fear conditioning results in high overlap in CA3 and CA1, similar to that of rats that have explored the context twice, but have not received footshock in it...
  49. The role of the circadian clock in encoding seasonal variations in day length
    ..be determined whether photoperiod encoding in the SCN differs between photoperiodic F344 and nonphotoperiodic Wistar rats. Seasonal variations in photoperiod may also affect neurological processes in humans...
  50. Juvenile trophic factors for the prevention and treatment of hippocampal aging
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    ..This cholinergic innervations develops during the first two postnatal weeks in rats and mice but its function declines in aging brain...
    William T Greenough; Fiscal Year: 2010
    ..for post-weaning cytogenesis in adolescence and young adulthood is present, even enhanced, in the motor cortex of rats given binge-like alcohol exposure during the neonatal period of rapid brain growth, compared to unexposed controls...
  52. Ethanol's Influence on Neural Mechanisms of Navigation
    Robert Stackman; Fiscal Year: 2009
    ..Previous behavioral studies have shown that acute ethanol disrupts spatial memory in rats and mice. In contrast, acute ethanol has minimal effects on the spatial firing of hippocampal neurons (place cells)...
  53. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
  54. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..of a broad-spectrum drug for TBI and to determine its potential mechanisms using fluid percussion injury model in rats. We have a comprehensive approach to evaluate the ability of CNB-001 to restore synaptic plasticity and energy ..
  55. Functional Activity Mapping of Brain Networks
    Carol A Barnes; Fiscal Year: 2010
    ..exhibited by the hippocampus influences the neocortical layers to which the hippocampus projects in young and aged rats. We expect that the outcome of the proposed project will have an important impact on our understanding of the ..
  56. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2011
    ..the amygdala will also be used to evaluate whether genes showing overlapping changes in BDs, SZs and PICRO-treated rats may be related to amygdalar activation of the HIPP...
  57. Resveratrol for Enriching Neurogenesis &Memory in the Aged
    Ashok K Shetty; Fiscal Year: 2011
    ..1, we will quantify the efficacy of long-term (28 days) administration of different doses of Resveratrol in aged rats for stimulating the proliferation of NSCs and increasing the extent of hippocampal neurogenesis...
  58. Gender Differences in the Neural Circuitry of Addiction
    Catherine S Woolley; Fiscal Year: 2011
    ..a combination of light and electron microscopy, western blotting, and whole-cell patch camp electrophysiology in rats to investigate whether and how chronic cocaine-induced changes in the dendritic arbor of nucleus accumbens neurons ..
  59. Food(cassava) cyanogen exposure and motor neuron degeneration
    ..and assess changes in selected indicators of protein misfolding in brain/spinal cord tissues of young Wistar rats kept on SAA-deficient diets and treated with linamarin, NaOCN (positive control) or equivalent amount of 5% ..
  60. Postnatal SSRI treatment: effects on serotonergic projections and gene expression
    Neil Allen Gray; Fiscal Year: 2012
    ..the postnatal period has been shown to produce opposing alterations in the emotional behavior of adult mice and rats. It has therefore been hypothesized that alterations of serotonin signaling during a developmental critical period ..
  61. Role of Metallothioneins in Isoflurane-Preconditioning of neurons in vitro.
    Adam C Hall; Fiscal Year: 2010
    ..work from my lab identified metallothionein I + II genes (MT-I + II) as among those significantly regulated in rat liver, kidney and heart following a 2% isoflurane exposure in vivo (Edmands et al., 2005)...
  62. GABA-B Receptor Modulation of Calcium Currents
    Michelle Mynlieff; Fiscal Year: 2010
    ..is that L-type current is facilitated in response to GABAB receptor activation in the neonatal neurons of the rat hippocampus...
  63. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..Pardo, 2003 #162}, decreases CREB phosphorylation &activity of CaM kinase IV {Tardito, 2007 #163} in rat hippocampal neurons. Lithium &valproate may reduce phosphorylation of rat GluR1 {Du, 2008 #164}...
  64. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    ..receptors will result in increased DSB repair;this hypothesis we will tested by measuring DSB repair activity in rat cortical neuronal cultures;2) Impairment of H2AX phosphorylation will result in increased glutamate toxicity due to ..
  65. Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and Calcineurin
    William A Sather; Fiscal Year: 2010
    ..These fluorescent fusion constructs will be transfected into HEK293 cells or cultured rat hippocampal neurons...
  66. Phosphorylation as a Determinant of BK Channel Expression and Localization
    James S Trimmer; Fiscal Year: 2010
    ..inroads in defining the in vivo phosphorylation sites on the primary or BK1 subunit of BK channels purified from rat brain...
  67. Structural consequences of TSC gene mutations in brain
    Peter B Crino; Fiscal Year: 2012
    ..in TSC brains that contribute to neurocognitive deficits and in vitro evidence suggests that reduction of Tsc1 in rat neurons leads to altered dendritic structure...
  68. Orexin Induced Gene and Protein Expression Patterns in the rLH
    ..2) Test in vitro whether OxA-induced activation of HIF-1[unreadable] mediates intracellular metabolic changes in rat rLH sections...
    Eric J Delpire; Fiscal Year: 2013
    ..g. WNKs and PKCs) that act upstream of SPAK and OSR1 in a rat primary afferent neuronal cell line...
    William Ross; Fiscal Year: 2009
    ..from stores mediated by IP3 in pyramidal cells in slices from the CA1 region of the hippocampus in Sprague Dawley rats. The first set of experiments will examine the properties of newly discovered spontaneous elementary events ("puffs"..
  71. MiR-15/107 microRNAs are important genetic regulators in Alzheimer disease
    Peter T Nelson; Fiscal Year: 2012
    ..We thus propose novel experiments in human brain and in primary rat brain-derived cultured cells...
  72. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..also demonstrated that there is elevated dopamine D1 receptor (D1R) expression in the prefrontal cortex of HIV-1Tg rats, and that these animals have greater METH-induced behavioral sensitization, as assessed by stereotypical head ..
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..initiate and promote ethanol-induced apoptotic death of beta-endorphin neurons in the hypothalamus of newborn rats. Furthermore, we will evaluate whether ethanol induces reactive oxygen species generation and inflammatory response ..
    DIPAK SARKAR; Fiscal Year: 2009
    ..initiate and promote ethanol-induced apoptotic death of beta-endorphin neurons in the hypothalamus of newborn rats. Furthermore, we will evaluate whether ethanol induces reactive oxygen species generation and inflammatory response ..
  75. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..following specific aims will be tested: 1) determine which ER subtype(s) reduce IT in aged, gonadectomized female rats, 2) determine the molecular mechanism(s) by which ERs alter ROS (ONOO- and O-2) through eNOS uncoupling, post-..
  76. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Eker rats harboring mutations in TSC2 develop spontaneous renal tumors at a very high incidence...
  77. Neuroprotective role of RAB3B in rodent models of Parkinson's disease
    Chee Yeun Chung; Fiscal Year: 2010
    ..to study the monomeric GTPase protein RAB3B that is highly enriched in VTA (A10) compared to SN (A9) both in rat and human midbrain...
    Raymond F Novak; Fiscal Year: 2010
    ..mechanistic molecular approaches, to identify the mechanism(s) which regulate CYP2E1 expression in primary cultured rat and human hepatocytes, and animals in vivo...
  79. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2010
    ..A transcription factor, purified from rat liver, with specificity for carbohydrate responsive elements (ChRE) found in the promoters of multiple genes ..
  80. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..accumulation, and (c) attenuated Rb phosphorylation after transient middle cerebral artery occlusion (tMCAO) in rat. Our studies strongly support SMS inhibition by D609 leading to cell cycle arrest...
  81. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..and blockers on mesenteric artery blood flow and systemic blood pressure measured acutely in anesthetized rats or in chronically instrumented conscious rats...
  82. Sodium-chloride co-transporter regulation in the kidney
    Alicia A McDonough; Fiscal Year: 2013
    ..The aims will be examined in rats treated acutely or chronically with agonists and inhibitors of RAS, NADPH oxidase, RSNA and altered salt diets...
  83. Liver Glucose Flux in Obesity and Diabetes
    Masakazu Shiota; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Zucker diabetic fatty (ZDF) rats, an animal model of human type 2 diabetes associated with obesity, have a blunted response to hyperglycemia with a failure to suppress net hepatic glucose production ..
    EDUARDO NILLNI; Fiscal Year: 2009
    ..Therefore: Aim #2. We will test the responsiveness of TRH neurons to NPY in lean versus DIO rats. Aim #3. We will test the hypothesis that NPY down regulates the prohormone convertases 1 and 2 (PC1/2). Aim #4...
  85. The Effect of Gastric Bypass Surgery on Renal Function and Metabolism
    Benjamin K Canales; Fiscal Year: 2013
    ..Currently, the mechanisms behind these adverse renal events are unknown. Preliminary data from an obese rat model of RYGB surgery indicates that gastric bypass causes more glomerular injury, interstitial macrophage ..
  86. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..with increased TRPV4 expression and phosphorylation in primary visceral afferents and (2) 12-ARs inhibit VH in rats with TNBS-induced colon inflammation partly by modulating TRPV4 phosphorylation....
  87. Examining the role of the Lissencephaly Protein, Lis1, in Dynein-Based Transport
    Deanna S Smith; Fiscal Year: 2013
    ..discovery of an important role for Lis1 and Nudel in regulating dynein-dependent axonal transport in cultured adult rat sensory neurons has led to the hypothesis that perturbing this regulatory network will cause neuronal dysfunction ..
  88. Neuronal Expression of Hemoglobin in Multiple Sclerosis Cortex
    Jennifer McDonough; Fiscal Year: 2013
    ..We have also found hemoglobin expression in primary cultures of neurons isolated from rat brain...
  89. Mechanisms of Alcohol Withdrawal Seizures: Role of L-type Ca2+ Channels
    PROSPER N'GOUEMO; Fiscal Year: 2013
    ..The objective of this application is to investigate AWS etiology in rats and mice by determining the role of LTCCs in the mechanisms underlying IC neuronal hyperexcitability in response to ..
  90. Bioartificial Brain Slices for Drug Screening
    ERIC STEPHEN GUIRE; Fiscal Year: 2013
    ..Acute brain slices, prepared from rats or mice, are currently the 'gold standard'preparation for characterizing neural tissue responses to drugs,..
  91. Mechanisms of Entorhinal Cortex Function
    Michael E Hasselmo; Fiscal Year: 2013
    ..on the coding of space by grid cells, head direction cells and conjunctive grid-by-head-direction cells in the rat medial entorhinal cortex...
  92. Development of Intravenous AAV Vectors for Intractable Epilepsy
    Thomas J McCown; Fiscal Year: 2013
    ..The libraries will be injected intravenously into rats with documented chronic, spontaneous seizure activity...
  93. Multisite analysis of hippocampal neuronal ensembles
    James J Knierim; Fiscal Year: 2013
    ..optogenetics, and juxtacellular labeling will be used to (a) record the spatial firing properties of DG neurons as rats explore different environments and (b) assign these properties to the specific cell types...
  94. Role of p70S6 kinase in the synaptic and behavioral deficits induced by stress
    Jason Dwyer; Fiscal Year: 2013
    ..to deliver a mutant, constitutively active version of p70 S6 kinase to the prefrontal cortex or hippocampus of rats before exposure to chronic stress...
  95. Molecular and Cellular Determinants of the Exercise Pressor Reflex in CHF
    Irving H Zucker; Fiscal Year: 2013
    ..that enhanced voltage-gated sodium channel (Nav) activity in muscle afferent neurons (DRG's) of CHF rats contributes to the enhanced afferent neuronal excitability and the EPR...
  96. Contribution of Multisensory Stimuli on Entorhinal Circuit Dynamics and the Menta
    ASHLEY LINDA KEES; Fiscal Year: 2013
    ..To do this, the firing activity of individual neurons will be recorded while a rat is exploring an environment in virtual reality...
  97. Altered phosphorylation of connexin 43 contributes to increased gap-junction coup
    HEIDI GRABENSTATTER; Fiscal Year: 2013
    ..studies demonstrate significant decreases in connexin phosphorylation 48 h after SE and in chronically epileptic rats 30 d after SE...
    Young Hoon Sung; Fiscal Year: 2013
    ..mitochondrial respiratory chain, and a single dose of METH causes mitochondrial dysfunction and oxidative stress in rat brain...
  99. Volatile anesthetic effects on aging brain
    Zhiyi Zuo; Fiscal Year: 2013
    ..study showed that isoflurane at a clinically relevant concentration impaired the learning and memory of old rats. This detrimental effect on old rats was attenuated by intravenous lidocaine, a local anesthetic that has anti-..
  100. Neurodevelopmental Effects of Cannabis and its Epigenetic Regulation
    Yasmin L Hurd; Fiscal Year: 2013
    ..Similar gene expression patterns were detected in the ventral striatum of rats exposed to ?-tetrahydrocannabinol (THC), the psychoactive component of cannabis, prenatally as well as during ..
    Anna Moszczynska; Fiscal Year: 2013
    ..We hypothesize that increasing their functions will provide neuroprotection in rats chronically and acutely exposed to METH...