Genomes and Genes
Alias: bovine, cattle, domestic cattle, domestic cow, Bos taurus, Bos bovis, Bos primigenius taurus, Bos Tauurus, Bovidae sp. Adi Nefas
Publications523 found, 100 shown here
- Organization of uroplakin subunits: transmembrane topology, pair formation and plaque compositionF X Liang
Epithelial Biology Unit, The Ronald O Perelmen Department of Dermatology, New York University Medical School, New York, NY 10016, U S A
Biochem J 355:13-8. 2001..Taken together, these results indicate that uroplakins form a tightly packed structure, that the four uroplakins interact specifically forming two pairs, and that both uroplakin pairs are required for normal urothelial plaque formation...
- Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and compositionBernard Grisart
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
Genome Res 12:222-31. 2002..trait locus (QTL) with a major effect on milk composition--particularly fat content--to the centromeric end of bovine chromosome 14...
- Double muscling in cattle due to mutations in the myostatin geneA C McPherron
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 94:12457-61. 1997..and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgian Blue and Piedmontese, which are known to have an increase in muscle mass relative to conventional cattle...
- Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and compositionBernard Grisart
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege Sart Tilman, Belgium
Proc Natl Acad Sci U S A 101:2398-403. 2004..used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait ..
- Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2Sebastien Fritz
UNCEIA, Genetics Team, Paris, France
PLoS ONE 8:e65550. 2013The regular decrease of female fertility over time is a major concern in modern dairy cattle industry...
- Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cowsJohn B Cole
Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
BMC Genomics 12:408. 2011..Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows...
- Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat contentAndreas Winter
Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
Proc Natl Acad Sci U S A 99:9300-5. 2002..Our mapping studies placed DGAT1 close to the region of a quantitative trait locus (QTL) on bovine chromosome 14 for variation in fat content of milk...
- L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthroughYoshihide Yamaguchi
Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
J Biol Chem 287:17765-76. 2012..Since this is the first finding of stop codon readthrough in a common mammalian protein, detailed analysis of L-MPZ expression will help to understand the mechanism of stop codon readthrough in mammals...
- Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)M Amano
Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
J Biol Chem 271:20246-9. 1996..The activated Rho-kinase subsequently phosphorylates MLC. This may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction...
- ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in BovidaeYang Yang
Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 12:13. 2011..These transpositions are lineage-dependent. The purpose of this study is to investigate the lineage-specific Y-chromosome genes in bovid...
- Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibilityPetra Sander
Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
J Biol Chem 280:37408-14. 2005..within the bovine PRNP gene have little or no effect on bovine spongiform encephalopathy (BSE) susceptibility in cattle. We have recently found a tentative association between PRNP promoter polymorphisms and BSE susceptibility in ..
- A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory responseArnaud Sartelet
Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
PLoS Genet 8:e1002581. 2012We report association mapping of a locus on bovine chromosome 3 that underlies a Mendelian form of stunted growth in Belgian Blue Cattle (BBC)...
- Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udderWei Yang
Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
Mol Immunol 45:1385-97. 2008..We examined here, if inadequate activation of the bovine TLR2 and TLR4 pathogen receptors by ligands derived from S...
- Programmed translational readthrough generates antiangiogenic VEGF-AxSandeepa M Eswarappa
Department of Cellular and Molecular Medicine, The Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Cell 157:1605-18. 2014..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. ..
- NMR structure of the bovine prion proteinF López García
Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule, Honggerberg, CH 8093 Zurich, Switzerland
Proc Natl Acad Sci U S A 97:8334-9. 2000The NMR structures of the recombinant 217-residue polypeptide chain of the mature bovine prion protein, bPrP(23-230), and a C-terminal fragment, bPrP(121-230), include a globular domain extending from residue 125 to residue 227, a short ..
- Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattleR Kambadur
AgResearch, Ruakura, Hamilton, New Zealand
Genome Res 7:910-6. 1997..The autosomal recessive mh locus causing double-muscling condition in these cattle maps to bovine chromosome 2 within the same interval as myostatin, a member of the TGF-beta superfamily of genes...
- Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection?A Sartelet
Unit of Animal Genomics, GIGA R and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
Anim Genet 43:604-7. 2012..1906T>C) in the bovine MRC2 gene causing the Crooked Tail Syndrome in Belgian Blue Cattle. We demonstrate that the ensuing substitution of the highly conserved Cysteine 636 with Arginine causes ..
- Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pHE Cabezon
Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom
J Biol Chem 275:25460-4. 2000b>Bovine IF(1), a basic protein of 84 amino acids, is involved in the regulation of the catalytic activity of the F(1) domain of ATP synthase. At pH 6.5, but not at basic pH values, it inhibits the ATP hydrolase activity of the enzyme...
- Crystal structure of rhodopsin: A G protein-coupled receptorK Palczewski
Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
Science 289:739-45. 2000..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
- Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)C K Hamilton
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Sex Dev 3:205-13. 2009..Previous studies have estimated that TSPY ranges from 50-200 copies in cattle. To examine TSPY localization on the Y chromosome we employed fluorescence in situ hybridization (FISH) and fiber-..
- Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6Hanne Gro Olsen
Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N 1432 Aas, Norway
Genetics 169:275-83. 2005..5 cM on chromosome 6 in Norwegian dairy cattle. This article aimed to refine this position by increasing the map density in the region by a set of single-..
- DGAT1 underlies large genetic variation in milk-fat composition of dairy cowsA Schennink
Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
Anim Genet 38:467-73. 2007..001). We conclude that selective breeding can make a significant contribution to change the fat composition of cow's milk.
- Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free stateT Tanaka
Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada
Nature 376:444-7. 1995..The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices...
- Domain structure of a mammalian myosin I betaO Reizes
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas 75235
Proc Natl Acad Sci U S A 91:6349-53. 1994We have determined the primary structure of a myosin I (called mammalian myosin I beta, MMI beta) from bovine brain and identified its functional domains. The protein was previously purified from brain and adrenal gland...
- Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysisAnne S Meyer
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 113:369-81. 2003..Understanding the distinct mechanisms governing eukaryotic and bacterial chaperonin function may reveal how TRiC has evolved to fold specific eukaryotic proteins...
- A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformationBo Thomsen
Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, DK 8830 Tjele, Denmark
Genome Res 16:97-105. 2006The extensive use of a limited number of elite bulls in cattle breeding can lead to rapid spread of recessively inherited disorders...
- Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81Changlu Liu
Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
J Biol Chem 284:2811-22. 2009..Our results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81. GPR81 may thus be an attractive target for the treatment of dyslipidemia and other metabolic disorders...
- Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH bindingG Zhou
Skirball Institute of Biomolecular Medicine, Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Cell Sci 114:4095-103. 2001..coli, and that the binding of uropathogenic bacteria to uroplakin Ia may play a key role in mediating the urothelial responses to bacterial attachment...
- Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoproteinX R Wu
Ronald O Perelman Department of Dermatology, New York University School of Medicine, NY 10016
J Cell Sci 106:31-43. 1993..The fact that of the three major proteins of AUM only UPIII has a significant cytoplasmic domain suggests that this molecule may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells...
- Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattleT Goldammer
Molecular Biology Research Division, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
Clin Diagn Lab Immunol 11:174-85. 2004..the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the bovine gene encoding the key PRR Toll-like receptor 9 (TLR9) and mapped its precise position on chromosome BTA22...
- Hydrogen peroxide is the major oxidant product of xanthine oxidaseEric E Kelley
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Free Radic Biol Med 48:493-8. 2010..Furthermore, XO bound to glycosaminoglycans on the apical surface of bovine aortic endothelial cells demonstrated a similar ROS production profile...
- An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattleCord Drogemuller
Institute of Genetics, University of Bern, Bern, Switzerland
PLoS ONE 6:e18931. 2011..The clinical signs of the disorder are similar to those of bovine progressive degenerative myeloencephalopathy (weaver syndrome) in Brown Swiss cattle but occur much earlier in ..
- Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransductionW A Gorczyca
Department of Ophthalmology, University of Washington, Seattle 98195
J Biol Chem 270:22029-36. 1995....
- Identification of core amino acids stabilizing rhodopsinA J Rader
Center for Computational Biology and Bioinformatics, Department of Molecular Biology and Biochemistry, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 101:7246-51. 2004..The observed high degree of conservation (78.9%) of this disulfide bond across all GPCR classes suggests that it is critical for the stability and function of GPCRs...
- Highly effective SNP-based association mapping and management of recessive defects in livestockCarole Charlier
Unit of Animal Genomics, GIGA Research and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège B34, 1 Avenue de l Hopital, 4000 Liege, Belgium
Nat Genet 40:449-54. 2008..We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle ..
- Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomesAnne Sophie Van Laere
Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
Genome Res 18:1884-95. 2008Here, we report the sequence characterization of the bovine pseudoautosomal boundary (PAB) and its neighborhood...
- Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence inductionJoo Yeun Oh
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Street South, Birmingham, AL 35294 0022, USA
Biochem J 411:297-306. 2008....
- Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamilyA T Byrne
Department of Biology, University of York, York, United Kingdom
Mol Reprod Dev 62:489-95. 2002..We have previously shown that apoptosis occurs in the preimplantation bovine embryo and is influenced by in vitro culture conditions...
- Bulldog dwarfism in Dexter cattle is caused by mutations in ACANJulie A L Cavanagh
Reprogen, The University of Sydney, PMB3, Camden, New South Wales 2570, Australia
Mamm Genome 18:808-14. 2007Bulldog dwarfism in Dexter cattle is one of the earliest single-locus disorders described in animals. Affected fetuses display extreme disproportionate dwarfism, reflecting abnormal cartilage development (chondrodysplasia)...
- The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilageP J Neame
Shriners Hospital for Crippled Children, Tampa, Florida 33612
J Biol Chem 269:21547-54. 1994..Based on anchored polymerase chain reaction analysis of the mRNA, there is some minor heterogeneity in the position of the 5' end of the message...
- TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?T G Berryere
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Anim Genet 34:169-75. 2003..The complete coding sequence of bovine TYRP1 was determined from cDNA derived from skin biopsies of cattle with various colours...
- Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1Chandreyee Das
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2280, USA
Virology 318:306-17. 2004..In the related bovine immunodeficiency virus (BIV), Tat recognizes its cognate TAR element with high affinity and specificity in the ..
- A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattleStacey N Meyers
Laboratory of Molecular Genetics, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
BMC Genomics 11:337. 2010..In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive ..
- Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cowsH Sadri
Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
J Anim Physiol Anim Nutr (Berl) 94:e194-202. 2010..Alternatively, it may indicate that post-transcriptional modifications of these factors came into play and may have concealed an involvement...
- Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockadeRyoyo Ikebuchi
Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
Vet Res 42:103. 2011..role of PD-L1 in BLV infection, we identified the bovine PD-L1 gene, and examined PD-L1 expression in BLV-infected cattle in comparison with uninfected cattle...
- Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localizationElke Albrecht
Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
PLoS ONE 7:e35282. 2012..ASIP mRNA abundance was determined by RT-qPCR in adipose and further tissues of cattle representing different breeds and crosses...
- Adipose tissue angiopoietin-like protein 4 messenger RNA changes with altered energy balance in lactating Holstein cowsD A Koltes
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
Domest Anim Endocrinol 43:307-16. 2012..The consistency and magnitude of the increase in ANGPTL4 mRNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow.
- Adiponectin deficit during the precarious glucose economy of early lactation in dairy cowsSarah L Giesy
Department of Animal Science, Ithaca, NY 14853, USA
Endocrinology 153:5834-44. 2012..These data suggest that reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance...
- Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesisLi Min Lu
Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, Heilongjiang, China
Molecules 18:263-75. 2012..proteomic technology was used to identify phosphoproteins responsible for milk protein synthesis in dairy cow mammary epithelial cells (DCMECs)...
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionM Uehata
Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
Nature 389:990-4. 1997..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
- Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibrilFabrice Raynaud
Cell Motility Laboratory, EPHE, UMR 5539, UM2, Montpellier, France
FEBS J 272:2578-90. 2005..Furthermore, calpain 1 is found to localize in myofibril fractures, described as proteolysis sites, in postmortem bovine skeletal red muscles, near the calcium deposits located at the N1 and N2 level...
- Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophilsM E Selsted
Department of Pathology, College of Medicine, University of California, Irvine 92717
J Biol Chem 268:6641-8. 1993A new family of cysteine-rich antimicrobial peptides from bovine neutrophils was isolated and characterized...
- Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter regionD Hills
Division of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
Anim Genet 32:231-2. 2001
- Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunitJie Zheng
Howard Hughes Medical Institute, Seattle, WA 98195, USA
Neuron 36:891-6. 2002..We find, surprisingly, that the channel contains three CNGA1 subunits and only one CNGB1 subunit. These results have implications for CNG channel function in particular and assembly of membrane proteins in general...
- Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1Jun Cai
School of Optometry and Vision Sciences, Cardiff University, UK
J Biol Chem 281:3604-13. 2006..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
- Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locusCristina Uboldi
Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
Mamm Genome 17:1130-9. 2006..We mapped SPRN in Bos taurus by comparative analysis of the locus and of the predicted flanking genes...
- Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPKPeter F Mount
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Atherosclerosis 200:28-36. 2008..test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid oxidation in endothelium, stimulations of bovine aortic endothelial cells (BAECs) with bradykinin were performed. BK stimulation caused a 2...
- Polymorphism in genes of growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF1) and its association with both the IGF1 expression in liver and its level in blood in Polish Holstein-Friesian cattleAndrzej Maj
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
Neuro Endocrinol Lett 29:981-9. 2008..Ghr and igf1 genes have been associated with milk and meat production of cattle. However, the molecular and physiological mechanisms underlying such associations are unknown...
- Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cellsShuzhen Liu
University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Mol Immunol 48:895-908. 2011..in MEC the role of NF-κB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle. Abrogating NF-κB binding to that site by introduction of a single point mutation blocks promoter activity of ..
- Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattleBrian W Brunelle
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010 USA
BMC Vet Res 4:36. 2008..These factors have been extensively studied in breeds of Bos taurus cattle in relation to classical bovine spongiform encephalopathy (BSE)...
- Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrilsTamotsu Zako
Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
Biophys J 96:3331-40. 2009..We demonstrate here that bovine insulin forms flexible filaments in the presence of a reducing agent, Tris (2-carboxyethyl) phosphine...
- Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channelU B Kaupp
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
Nature 342:762-6. 1989The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, ..
- How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondriaJonathan R Gledhill
Medical Research Council Dunn Human Nutrition Unit, Cambridge CB2 0XY, United Kingdom
Proc Natl Acad Sci U S A 104:15671-6. 2007The structure of bovine F(1)-ATPase inhibited by a monomeric form of the inhibitor protein, IF(1), known as I1-60His, lacking most of the dimerization region, has been determined at 2.1-A resolution...
- Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beefTsuyoshi Abe
National Livestock Breeding Center, 1 Odakurahara, Nishigo, Fukushima, Japan
Biochem Genet 47:397-411. 2009..coding sequence of the bovine fatty acid synthase (FASN) gene of an F2 population from Japanese Black and Limousin cattle. Two mutations, g.16024A>G and g...
- Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcriptsU Wissenbach
Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg Saar, Germany
FEBS Lett 429:61-6. 1998..Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four ..
- AluI polymorphism of the bovine growth hormone (GH) gene, resumption of ovarian cyclicity, milk production and loss of body condition at the onset of lactation in dairy cowsO Balogh
Faculty of Veterinary Science, Szent Istvan University, 1078 Budapest István u 2, Hungary
Theriogenology 71:553-9. 2009..We concluded that, under field conditions, AluI polymorphism of the bovine GH gene had no effect on the interval from calving to first ovulation and could not be directly related to ..
- Molecular characterization of the DDX3Y gene and its homologs in cattleW S Liu
Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Cytogenet Genome Res 126:318-28. 2009..Here, we report the characterization of the bovine (b) DDX3Y gene and its homologs DDX3X and PL10...
- Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cellsChiaki Murayama
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Cell Biol Int 34:531-6. 2010..receptors, CXCR1 and IL-1R1 in the theca cells of PRF (preselection) and POF (postselection follicles) from the bovine ovary...
- The major protein of bovine seminal plasma, PDC-109, is a molecular chaperoneRajeshwer Singh Sankhala
School of Chemistry, University of Hyderabad, Hyderabad 500046, India
Biochemistry 49:3908-18. 2010The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
- Interaction of mammalian seminal plasma protein PDC-109 with cholesterol: implications for a putative CRAC domainSilvia Scolari
Department of Biology, Humboldt University Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
Biochemistry 49:9027-31. 2010..To characterize the interaction between the bovine Fn2 protein PDC-109 and cholesterol, we have investigated the effect of PDC-109 on the dynamics of fluorescent ..
- Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membraneJ H Lin
Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016
J Biol Chem 269:1775-84. 1994..In this paper we describe the precursor sequence, processing and in vitro membrane insertion properties of bovine uroplakin II (UPII), a 15-kDa major protein component of AUM...
- Structure of the alpha beta tubulin dimer by electron crystallographyE Nogales
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Nature 391:199-203. 1998....
- Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosisSean D Conner
The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 156:921-9. 2002..These results also lend support to the idea that clathrin-mediated endocytosis is controlled by cycles of phosphorylation/desphosphorylation...
- Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosisPatrick Schafer
Institute of Biochemistry, Justus Liebig University, Heinrich Buff Ring 58, D 35392 Giessen, Germany
J Mol Biol 338:217-28. 2004..In addition, we have identified two putative DNA/RNA binding residues of bovine EndoG, Arg135 and Arg186, strictly conserved only among mammalian members of the nuclease family, suggesting a ..
- AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stressYingjia Zhang
Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
Arterioscler Thromb Vasc Biol 26:1281-7. 2006..In this study, we investigate the regulation of the AMPK-eNOS pathway in vascular endothelial cells (ECs) by shear stress and the activation of aortic AMPK in a mouse model with a high level of voluntary running (High-Runner)...
- Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattleHanne Gro Olsen
BoviBank Ltd, Aas, Norway
BMC Genet 8:32. 2007..Studies performed in other cattle populations have proposed polymorphisms in two different genes (ABCG2 and OPN) as the underlying functional QTL ..
- Epistasis between calpain 1 and its inhibitor calpastatin within breeds of cattleW Barendse
Commonwealth Scientific and Industrial Research Organization Livestock Industries, Queensland Bioscience Project, 306 Carmody Road, St Lucia 4067, Queensland, Australia
Genetics 176:2601-10. 2007..on chromosome 29, with causative mutations for QTL variation at calpastatin (CAST), located on chromosome 7, in cattle. First we identified potential causative mutations at CAST and then genotyped these along with putative causative ..
- Tenascin-X increases the stiffness of collagen gels without affecting fibrillogenesisYoran Margaron
Institut de Biologie et Chimie des Proteines, IFR 128 Biosciences Lyon Gerland, CNRS UMR 5086, Universite de Lyon, 7 passage du Vercors, F 69367 Lyon Cedex 07, France
Biophys Chem 147:87-91. 2010....
- Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid depositionRosemarie Weikard
Research Unit Molecular Biology, Leibniz Institute for Farm Animal Biology FBN, Dummerstorf, Germany
Physiol Genomics 42:79-88. 2010..effect of the NCAPG/LCORL locus on human height in genome-wide association studies, the results obtained for bovine NCAPG might add valuable, comparative information on the physiological background of genetically determined ..
- Two-stage autolysis of the catalytic subunit initiates activation of calpain IU J Zimmerman
Institute for Environmental Medicine, University of Pennsylvania Medical School, Philadelphia 19104
Biochim Biophys Acta 1078:192-8. 1991Calcium-induced autolysis of bovine erythrocyte calpain I occurs in multiple stages. Initially, a 14 amino acid segment is cleaved from the N-terminus of the native 80 kDa catalytic subunit, yielding a 78 kDa form of the subunit...
- Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neuronsB Ullrich
Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235
Neuron 14:497-507. 1995..Characterization of many independent bovine neurexin I alpha cDNAs suggests that different splice sites are used independently...
- Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromereK F Sullivan
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
J Cell Biol 127:581-92. 1994..These data clearly indicate that the assembly of centromeres is driven, at least in part, by the incorporation of a novel core histone into centromeric chromatin...
- Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stressEleni Tzima
Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 278:31020-3. 2003..Thus, shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex...
- Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cellsEveline M Ibeagha-Awemu
Department of Animal Science, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
Vet Res 39:11. 2008b>Bovine mammary epithelial cells contribute to the innate immune response to intramammary infections by recognizing pathogens through specialized pattern recognition receptors...
- Cofactor A is a molecular chaperone required for beta-tubulin folding: functional and structural characterizationR Melki
Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
Biochemistry 35:10422-35. 1996..Our data imply that cofactor A is a chaperone involved in tubulin folding...
- A novel cochaperonin that modulates the ATPase activity of cytoplasmic chaperoninY Gao
Department of Biochemistry, New York University Medical Center, New York 10016
J Cell Biol 125:989-96. 1994..Moreover, while GroES functions as a heptameric ring, cofactor A behaves as a dimer. Thus, cofactor A is a novel cochaperonin that is structurally unrelated to GroES...
- Crystal structure of the adenylyl cyclase activator GsalphaR K Sunahara
Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9041, USA
Science 278:1943-7. 1997....
- An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometriumEric Madore
Unité de Recherche en Ontogénie et Reproduction et Département d Obstétrique et Gynécologie, Centre Hospitalier Universitaire de Quebec, Universite Laval, Sainte Foy, Quebec G1V 4G2, Canada
J Biol Chem 278:11205-12. 2003..Taken together, these data point to this newly identified enzyme as the functional endometrial PGFS...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Assignment of SRY, ANT3, and CSF2RA to the bovine Y chromosome by FISH and RH mappingWan Sheng Liu
Department of Animal Biotechnology, College of Agriculture, Biotechnology, and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
Anim Biotechnol 15:103-9. 2004..RH mapping with a 7000-rad cattle hamster whole-genome radiation hybrid panel further defined the ANT3 and CSF2RA position in relationship to ..
- R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstableTeresa M Treweek
Department of Chemistry, University of Wollongong, NSW, Australia
FEBS J 272:711-24. 2005..These characteristics may explain the involvement of R120G alphaB-crystallin with human disease states...
- Selection of reference genes for quantitative real-time PCR in bovine preimplantation embryosKaren Goossens
Department of Animal Nutrition, Genetics, Breeding and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, B 9820 Merelbeke, Belgium
BMC Dev Biol 5:27. 2005..Normalization of the data using unstable controls can result in erroneous conclusions, especially when only one reference gene is used...
- Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cellsX R Wu
Department of Urology, New York University School of Medicine, New York 10016, USA
J Biol Chem 270:29752-9. 1995..AUM thus provides an excellent model system for studying the targeting, processing, and assembly of TM4 proteins...
- Pregnancy-associated bovine and ovine glycoproteins exhibit spatially and temporally distinct expression patterns during pregnancyJ A Green
Department of Animal Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Biol Reprod 62:1624-31. 2000..They show structural resemblance to pepsin and related aspartic proteinases. A total of 21 bovine (bo) PAG and 9 ovine (ov) PAG cDNA have been identified...
- Molecular determinants of oocyte competence: potential functional role for maternal (oocyte-derived) follistatin in promoting bovine early embryogenesisKyung Bon Lee
Laboratory of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Endocrinology 150:2463-71. 2009..Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis...
- Dissection of genetic factors modulating fetal growth in cattle indicates a substantial role of the non-SMC condensin I complex, subunit G (NCAPG) geneAnnett Eberlein
Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
Genetics 183:951-64. 2009..We identified a highly significant quantitative trait locus (QTL) affecting fetal growth on bovine chromosome 6 in a specific resource population, which was set up by consistent use of embryo transfer and foster ..
- Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?N Forde
School of Agriculture, Food Science and Veterinary Medicine, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
Biol Reprod 85:144-56. 2011This study sought to determine the earliest response of the bovine uterine endometrium to the presence of the conceptus at key developmental stages of early pregnancy...
- Three-dimensional structure of recoverin, a calcium sensor in visionK M Flaherty
Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305
Cell 75:709-16. 1993..The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs...
- SNAP receptors implicated in vesicle targeting and fusionT Sollner
Rockefeller Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Nature 362:318-24. 1993..based on the natural binding of these proteins to their targets was used to isolate SNAP receptors (SNAREs) from bovine brain...
- Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activityR Ischia
Department of Pharmacology, University of Innsbruck, A 6020 Innsbruck, Austria
J Biol Chem 272:11657-62. 1997..Several NESP55 cDNA clones were isolated from bovine chromaffin cell libraries. The cDNA sequence of NESP55 totals 1499 nucleotides...
- Antibodies and Congenital Neospora Caninum TransmissionGARY HALDORSON; Fiscal Year: 2004..Transplacental transmission of neospora caninum results in abortions, stillbirths, and congenital infection in cattle and dogs. This apicomplexan parasite is similar to Toxoplasma gondii and Plasmodium sp...
- S. typhimurium Genes Required for Colonization of CattleHelene Andrews Polymenis; Fiscal Year: 2004..typhimurium variants (phage types DT2 and DT99) that cause fatal pigeon paratyphoid do not persist in cattle. The objective of this proposal is to identify the genes responsible for the epidemiologic success of S...
- Biochemical Detection of Prions in BloodJoaquin Castilla; Fiscal Year: 2005..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great concern about a possible epidemic of Creutzfeldt-Jakob disease...
- Claudio Soto; Fiscal Year: 2014..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great public health concern...
- Stephen L Hajduk; Fiscal Year: 2014DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
- Christopher P Jaroniec; Fiscal Year: 2015..disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Mammalian prions propagate by a mechanism involving the conformational conversion of a largely a-helical cellular ..
- Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary SuperovulatBRUCE DALE WEINTRAUB; Fiscal Year: 2012..in CHO-DG44 cells in preparation for Phase 2 large-scale production, purification and superovulation studies in cattle. This completely novel recombinant bFSH analog protected by international patents until 2032 &without a known ..
- F Nina Papavasiliou; Fiscal Year: 2014..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
- Mingming Wu; Fiscal Year: 2014..Infertility affects about 7% of married couples in the US and the success rate of artificial insemination in the cattle industry has been dropping over the past several years...
- HEATHER MICHELLE FRITZ; Fiscal Year: 2015..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
- Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigenAna M Espino; Fiscal Year: 2013..hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
- Pablo Juan Ross; Fiscal Year: 2016..Early embryonic mortality is a major cause of infertility in dairy cattle and humans...
- Christina Sigurdson; Fiscal Year: 2016..Zoonotic prion transmission is of concern, as the bovine spongiform encephalopathy (BSE) epidemic has led to nearly 200 cases of prion infection in humans...
- Se Jin Lee; Fiscal Year: 2014..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has ..
- Mark D Zabel; Fiscal Year: 2016..spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob disease in humans...
- Vanessa Sperandio; Fiscal Year: 2016..rumen, suggest an important role for SdiA- AHL mediated regulation of EHEC genes necessary for colonization of the bovine gastrointestinal (GI) tract...
- Adam Zlotnick; Fiscal Year: 2014..Dodecahedra share point symmetry with, and are dual to, icosahedra.) We have chosen to examine Bovine Enterovirus (BEV) a non-pathogenic relation of Poliovirus and Human Enterovirus-71...
- Bibo Li; Fiscal Year: 2016..applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
- Artiodactyl Gene Modification with Tal Effector NucleasesSCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2012..studies proposed here will establish a new paradigm for the genetic modification of artiodactyls (pigs, sheep, and cattle) for use as large animal models of human disease and the production of biomedical materials...
- Claudio Soto; Fiscal Year: 2016..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the disease from cattle to humans have caused ..
- Investigation of Occupational Exposure to and Infection by MRSA in Rural IowaTara Smith; Fiscal Year: 2012..We will examine 30 farms during this research, including farms with live swine, cattle, and poultry. In the second part of our research plan, we will examine transmission of S...
- Evidence based control strategies of Sleeping Sickness vectorsSerap Aksoy; Fiscal Year: 2012..is at risk of HAT outbreaks due to ongoing epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense)...
- Structure and assembly of the fungal prion HET-sWilliam N Wan; Fiscal Year: 2013..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of Creutzfeldt-Jakob disease (CJD) in humans...
- Lisa Murphy; Fiscal Year: 2016..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to ..
- Claudio Soto; Fiscal Year: 2014..disease (sCJD), the most common form, and variant CJD (vCJD) which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy...
- James D Bangs; Fiscal Year: 2015..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
- GREGORY CHARLES GRAY; Fiscal Year: 2016..Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing ..
- Julia K Gilden; Fiscal Year: 2015..protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
- Peng George Wang; Fiscal Year: 2016..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
- High Throughput Screening for Foot and Mouth Disease Virus AntiviralsJohn F Atkins; Fiscal Year: 2013DESCRIPTION (provided by applicant): The infection of cattle with Foot and Mouth Disease Virus (FMDV) causes not only great economic damage but great popular panic, e.g...
- LINDA HICKAM; Fiscal Year: 2014..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, ..
- Julia F Charles; Fiscal Year: 2015..A recent publication has identified a nearly identical phenotype in cattle that lack SLC4A2...
- Key molecular mechanisms of extraneural pathogenesis and transmission of TSEsMark D Zabel; Fiscal Year: 2012..These include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
- Thomas E Spencer; Fiscal Year: 2016..endometrial receptivity an pregnancy success, which will increase production efficiency and profitability of cattle enterprises...
- The development of a recombinant vaccine against human onchocerciasisSara Lustigman; Fiscal Year: 2013..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
- Shinji Makino; Fiscal Year: 2014..disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results in ..
- Kirk E Smith; Fiscal Year: 2014..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
- Philip C Hopewell; Fiscal Year: 2014..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
- Robert Sheridan; Fiscal Year: 2014..If funded we propose to expand the inspection and surveillance testing of cattle feeds and feed ingredients manufactured and distributed in NY State...
- CLAUDIA G COLES; Fiscal Year: 2014..WSDA describes Washington State's vulnerability to BSE agent release from imported Canadian cattle in age cohorts shared by the ongoing BSE positives identified by Canadian BSE surveillance...
- EVC2: A novel modulator in tooth developmentYoshiyuki Mochida; Fiscal Year: 2013..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of ..
- Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrheaLinda J Saif; Fiscal Year: 2010..of state-of-the-art technology for diagnosis (assays, reagents) and treatments (vaccines) for RV infections of cattle, the major agricultural commodity in Argentina...
- LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALEReginald Valdez; Fiscal Year: 1999..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
- MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUSGERTRUDE BUEHRING; Fiscal Year: 2007..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...
- Characterization of de novo generation of infectious prionsJoaquin Castilla; Fiscal Year: 2009..The occurrence of spontaneous cases of prion diseases in humans (sporadic CJD) and in other species, i.e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence ..
- Preventing Human Prion Diseases - Inactivation of PrionsStanley B Prusiner; Fiscal Year: 2010..plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable strain reported to date...
- 2009 Spirochetes, Biology ofDavid A Haake; Fiscal Year: 2010..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
- Immunogenicity of the Type IV Secretin SystemWENDY CATHERINE BROWN; Fiscal Year: 2012..By testing cattle that express a diverse repertoire of class II haplotypes, representative of the diversity of MHC class II ..
- REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEIChing Wang; Fiscal Year: 2009..are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle. They are a family of sickness in humans and nagana in cattle...
- Structural basis of species-specific infectivities of two prion strainsPeter M Tessier; Fiscal Year: 2010..infectious proteins that cause devastating neurodegenerative diseases (transmissible encephalopathies) in humans, cattle and other mammals...
- Assessing the Transmissibility of CWD to HumansQingzhong Kong; Fiscal Year: 2010..be transmitted to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the ..
- Characterization of prion protein conformational changesVALERIE D DAGGETT; Fiscal Year: 2010..prion diseases, include Creutzfeldt-Jakob disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk...
- Role of Fetal Steroids in Formation and Activation of Bovine Ovarian FolliclesJoanne E Fortune; Fiscal Year: 2010..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal ..
- Mechanism of membrane permeabilization by a cytolytic high density lipoproteinJOHN MATTHEW HARRINGTON; Fiscal Year: 2010..innate immunity against the mammalian parasite Trypanosoma brucei brucei, the causative agent of Nagana in African cattle. The morphologically indistinct T. brucei subspecies T. b. rhodesiense and T. b...
- RNA CAPPING IN TRYPANOSOMESChristian Tschudi; Fiscal Year: 2012..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
- Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic LeptospiraJeffrey Smith; Fiscal Year: 2010..The World Health Organization lists the groups of people at risk of the infection ranging from cattle and pig farmers to veterinarians, butchers and slaughterhouse workers to children playing in rain puddles or mud, ..
- Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer RiskYoung C Lin; Fiscal Year: 2010..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
- A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200WARNER KING HUH; Fiscal Year: 2012..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
- SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTINGShinichiro Kurosawa; Fiscal Year: 2011..There are certain strains of dangerous E. coli bacteria that can infect crops or cattle, and can be transmitted through our food distribution system to thousands of households...
- Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine FetusesKenneth L White; Fiscal Year: 2011..and preeclampsia, which is associated with abnormal placentation, occur at increased frequency in human and bovine pregnancies established by assisted reproductive technologies such as in vitro fertilization (IVF)...
- The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia boviKERRY SUE SONDGEROTH; Fiscal Year: 2011..This project will use Babesia bovis infection of cattle as a natural animal model of cytoadherence and virulence, and will address a significant knowledge gap to ..
- ANALYSIS OF TRYPANOSOME MRNA SYNTHESIS BY GENE TRANSFERVivian Bellofatto; Fiscal Year: 2010..In Africa, Trypanosoma brucei ssp. infect humans and domestic cattle, causing African sleeping sickness and Nagana, respectively. Human infection by the subspecies T. b...
- REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEICHING CHUNG WANG; Fiscal Year: 2012..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
- Structural Characterization of Prion Isoforms in Multiple TSE DiseasesMICHELE ANN MCGUIRL; Fiscal Year: 2012..Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
- Impact of Microparticles on Oral TSE InfectionsJoel A Pedersen; Fiscal Year: 2012..are transmissible neurologic disorders that can affect animals (sheep scrapie, cervid chronic wasting disease, bovine spongiform encephalopathy) and humans (Creutzfeldt-Jakob disease and Kuru)...
- LATENCY AND LEUKOMOGENICITY OF BOVINE LEUKEMIA VIRUSGary Cockerell; Fiscal Year: 1991Bovine leukemia virus (BLV) is an important, naturally occurring, endermic, retroviral disease of cattle, and a valuable comparative biomedical animal model of analogous human T cell lymphotropic retroviral (HTLV) infections...
- APRIL DAWN HUNT; Fiscal Year: 2014..The activities include: 1) reducing drug tissue residue violations in dairy cattle through a Hazard Analysis and Critical Control Points (HACCP) based approach;2) developing best practices for an ..
- REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLASTGeorge Seidel; Fiscal Year: 1993..that communicate its presence to the mother have been identified: in sheep, ovine trophoblast protein-1 (oTP-1); cattle, (bTP- 1); and humans, human chorionic gonadotropin (hCG)...
- IDENTIFICATION OF BABESIA IMMUNOGENS WITH TH CELWendy Brown; Fiscal Year: 2000..Immunoregulatory mechanisms in cattle are much more like those of humans than mice, so this outbred large animal species provides an alternative system ..
- INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUMR Roberts; Fiscal Year: 1999..of embryo-derived interferons (IFN's) and other cytokines in triggering maternal responses to early sheep, cattle, pig and mouse embryos...
- Biosensor for Rapid Detection of PrionThomas Hazel; Fiscal Year: 2005Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy are transmissible, neurodegenerative and fatal prion diseases of humans and cattle, respectively...
- MODELS OF HYPOXIC PULMONARY HYPERTENSIONArchibald Alexander; Fiscal Year: 1980..This response to hypoxia which occurs in most mammalian species including man, is particularly pronounced in cattle and also marked in swine...
- Producing Polyclonal Human Antibodies to AnthraxThillainayagam Sathiyaseelan; Fiscal Year: 2005..Hematech is developing a genetically modified line of cattle that will produce human instead of bovine immunoglobulin...
- CFI Inactivation of Human PlasmaTREVOR CASTOR; Fiscal Year: 2009..fluid inactivation) process inactivates enveloped viruses such as MuLV, VSV, TGE, BVD, Sindbis and HIV in fetal bovine serum by a lipid solubilization mechanism, similar to the solvent detergent method...
- Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP SynthaseZulfiqar Ahmad; Fiscal Year: 2009..b>Bovine X-ray crystal structure of catalytic sites indicates the presence of some other residues which seem to be involved ..
- Receptor/Ligand Signals for Ovarian Follicular AngiogenesisLeon J Spicer; Fiscal Year: 2010..In preliminary studies using experimental paradigms developed in our bovine granulosa and theca cell model, we demonstrated that: 1) abundance of ANG and FGF9 mRNA in bovine granulosa cells ..
- NEUROCHEMICAL CORRELATES OF CEREBELLAR DEVELOPMENTAndrej Rotter; Fiscal Year: 1992The aim of this proposal is to study the expression gamma-aminobutyric acid/benzodiazepine (GABA/BZ) receptors in bovine and murine cerebellum during development...
- QTL and QTL Genes Underlying Lactation PerformanceDarryl L Hadsell; Fiscal Year: 2010..Despite these findings, however, the genes that contribute to milk production are largely unidentified. In the bovine, there are quantitative trait loci (QTL) for milk volume present on all 29 autosomes...
Patents109 found, 100 shown here
- Pharmaceutical compositions for treating and/or preventing esophageal stricturePatent Number: WO2016024524-A; Date:2016-02-18
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- CHEMOKINE-CYTOKINE FUSION PROTEIN AND ITS USEPatent Number: JP2016503434-A; Date:2016-02-04
- Method for detecting chromosomal chimeraPatent Number: JP2016049076-A; Date:2016-04-11
- Method for Assessment of Bovine Conception RatePatent Number: JP2016054677-A; Date:2016-04-21
- METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124Patent Number: JP2016507218-A; Date:2016-03-10
- Hornless LivestockPatent Number: JP2016507228-A; Date:2016-03-10
- PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTSPatent Number: JP2016506743-A; Date:2016-03-07
- Method of Producing MicroparticlesPatent Number: JP2016507550-A; Date:2016-03-10
- Method of determining cell propertyPatent Number: JP2016093135-A; Date:2016-05-26
- The internal standard polynucleotide of animal, and method for detecting target polynucleotide using the samePatent Number: JP2016093147-A; Date:2016-05-26
- Gene marker, method, reporter vector, primer set and assay kit for measuring cell characteristics of tested cellPatent Number: JP2016101161-A; Date:2016-06-02
- Adverse Side-Effects Associated with Administration of an Anti-Hyaluronan Agent and Methods for Ameliorating or Preventing the Side-EffectsPatent Number: JP2016106099-A; Date:2016-06-16
- Stem Cell Microparticles and miRNAPatent Number: JP2016513095-A; Date:2016-05-12
- OLIGOSACCHARIDE COMPOSITIONS, GLYCOPROTEINS AND METHODS TO PRODUCE THE SAME IN PROKARYOTESPatent Number: JP2016518114-A; Date:2016-06-23
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- Nucleic acids sequence of a cell death-inducible vector, and the transgenic silkmoth strains carrying the DNA fragment inducing tissue-specific cell deathPatent Number: WO2016125885-A; Date:2016-08-11
- FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITYPatent Number: JP2016520060-A; Date:2016-07-11
- Compositions for use in cartilage breakdownPatent Number: JP2016520603-A; Date:2016-07-14
- Compositions for use in cartilage breakdownPatent Number: JP2016524614-A; Date:2016-08-18
- Method for production of nonhuman large mammal or fish generating gametes originated from another individualPatent Number: WO2016163386-A; Date:2016-10-13
- Genetically engineered and acid resistant yeast cell with enhanced ERG5 activity and method for producing lactate using the samePatent Number: KR1020160012561-A; Date:2016-02-03
- Genetically engineered and acid resistant yeast cell with ehanced radiation sensitivity complementing kinase activity and method for producing lactate using the samePatent Number: KR1020160012562-A; Date:2016-02-03
- Genetically engineered and stress resistant yeast cell with enhanced activity of MSN2 and method for producing lactate using the samePatent Number: KR1020160013762-A; Date:2016-02-05
- Method for preparing bio-pharmaceutical protein fused to bovine beta-caseinPatent Number: KR1020160017870-A; Date:2016-02-17
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