pig

Summary

Alias: pigs, swine, wild boar, Sus scrofa, Sus scrofa Linnaeus, 1758, Sus scrofus

Top Publications

  1. pmc A new method for predicting signal sequence cleavage sites
    G von Heijne
    Nucleic Acids Res 14:4683-90. 1986
  2. ncbi The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs
    Q L Peng
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045, Nanchang, China
    Anim Genet 38:397-400. 2007
  3. pmc Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication
    Lalit K Beura
    Morrison Research Center, 4240 Fair Street, East Campus, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    J Virol 85:12939-49. 2011
  4. doi Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
  5. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
  6. ncbi A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
    D Milan
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique INRA, 31326 Castanet Tolosan, France
    Science 288:1248-51. 2000
  7. ncbi Timing of Plk1 and MPF activation during porcine oocyte maturation
    Martin Anger
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Mol Reprod Dev 69:11-6. 2004
  8. pmc A missense mutation in PPARD causes a major QTL effect on ear size in pigs
    Jun Ren
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    PLoS Genet 7:e1002043. 2011
  9. doi Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway
    JinYoung Kim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Biol Reprod 88:113. 2013
  10. doi Patterns of corpora lutea growth and progesterone secretion in sows with thrifty genotype and leptin resistance due to leptin receptor gene polymorphisms (Iberian pig)
    P Gonzalez-Añover
    NUTEGA, Coslada, Madrid, Spain
    Reprod Domest Anim 46:1011-6. 2011

Research Grants

  1. BONE MARROW CULTURE AND ENGRAFTMENT IN A SWINE MODEL
    David Sachs; Fiscal Year: 1999
  2. High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
    Randall S Prather; Fiscal Year: 2010
  3. Screen for Identification of Important Human Birth Defect Models in Swine
    Kate G Ackerman; Fiscal Year: 2010
  4. Xiankai Sun; Fiscal Year: 2014
  5. Development of Ultrafine Particles for Intranasal Delivery of Antipsychotics
    SANDRA EDITH NORIEGA; Fiscal Year: 2013
  6. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
  7. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
  8. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
  9. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
  10. DOROTHY EILEEN VATNER; Fiscal Year: 2014

Patents

  1. GENETIC TECHNIQUES FOR MAKING ANIMALS WITH SORTABLE SPERM
  2. RECOMBINATION ACTIVATING GENE 2 GENE TARGETING VECTOR, PRODUCTION OF SCID-LIKE MINIATURE PIGS BY TALEN-MEDIATED GENE TARGETING AND USE THEREOF
  3. INTERLEUKIN 2 RECEPTOR GAMMA GENE TARGETING VECTOR, PRODUCTION OF IMMUNE CELL-DEFICIENT TRANSGENIC CLONED MINI PIG HAVING VECTOR INTRODUCED THEREIN, PREPARATION METHOD THEREFOR AND USE THEREOF
  4. HETEROZYGOUS MODIFICATIONS OF TUMOR SUPPRESSOR GENES AND SWINE MODEL OF NEUROFIBROMATOSIS TYPE 1
  5. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  6. Hornless Livestock
  7. INHIBITORS OF COMPLEMENT ACTIVATION
  8. FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITY
  9. GENETIC TECHNIQUES FOR MAKING ANIMALS WITH SORTABLE SPERM
  10. Disease model pigs with a stable phenotype and a method for producing thereof

Detail Information

Publications467 found, 100 shown here

  1. pmc A new method for predicting signal sequence cleavage sites
    G von Heijne
    Nucleic Acids Res 14:4683-90. 1986
    ..The predictive accuracy is estimated to be around 75-80% for both prokaryotic and eukaryotic proteins...
  2. ncbi The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs
    Q L Peng
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045, Nanchang, China
    Anim Genet 38:397-400. 2007
    ..243A>G mutation, we argue that the inheritance of F4ab and F4ac receptors might be under the control of two closely linked loci...
  3. pmc Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication
    Lalit K Beura
    Morrison Research Center, 4240 Fair Street, East Campus, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    J Virol 85:12939-49. 2011
    Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine results in substantial economic losses to the swine industry worldwide...
  4. doi Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
    ..Higher BNP mRNA expression in the PS is consistent with a reduction in contractile function in this region, while higher CNP mRNA expression in the OS suggests the presence of concomitant endothelial dysfunction in the remote region...
  5. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..A paternally expressed QTL affecting muscle growth, fat deposition and size of the heart in pigs maps to the IGF2 (insulin-like growth factor 2) region...
  6. ncbi A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
    D Milan
    Laboratoire de Genetique Cellulaire, Institut National de la Recherche Agronomique INRA, 31326 Castanet Tolosan, France
    Science 288:1248-51. 2000
    A high proportion of purebred Hampshire pigs carries the dominant RN- mutation, which causes high glycogen content in skeletal muscle. The mutation has beneficial effects on meat content but detrimental effects on processing yield...
  7. ncbi Timing of Plk1 and MPF activation during porcine oocyte maturation
    Martin Anger
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Mol Reprod Dev 69:11-6. 2004
    ..We find that Plk1 is activated before MPF, which is consistent with its role in activating MPF in mammalian oocytes...
  8. pmc A missense mutation in PPARD causes a major QTL effect on ear size in pigs
    Jun Ren
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    PLoS Genet 7:e1002043. 2011
    ..Historically, the large-ear feature has been selected for the ancient sacrificial culture in Erhualian pigs. By using a selective sweep analysis, we then refined the critical region to a 630-kb interval containing 9 ..
  9. doi Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway
    JinYoung Kim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Biol Reprod 88:113. 2013
    During the peri-implantation and early placentation periods in pigs, conceptuses (embryo and its extra-embryonic membranes) undergo dramatic morphological changes and differentiation that require the exchange of nutrients (histotroph) and ..
  10. doi Patterns of corpora lutea growth and progesterone secretion in sows with thrifty genotype and leptin resistance due to leptin receptor gene polymorphisms (Iberian pig)
    P Gonzalez-Añover
    NUTEGA, Coslada, Madrid, Spain
    Reprod Domest Anim 46:1011-6. 2011
    ..by corpora lutea dynamics and progesterone secretion, in 10 sows with obesity/leptin resistance genotype (Iberian pig) and 10 females of lean commercial crosses (Large White × Landrace)...
  11. doi Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica
    Timothée Bruel
    Institut National de la Recherche Agronomique, UR1282, Infectiologie Animale et Sante Publique, Nouzilly, Tours, France
    Dev Comp Immunol 34:562-71. 2010
    ..Our data shed light on the understanding of the early response of polarized intestinal cells to E. histolytica and identified a potential involvement of SOCS2 in the parasite regulation of the host response...
  12. doi Molecular characterization, induced expression, and transcriptional regulation of porcine S100A12 gene
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, PR China
    Mol Immunol 47:1601-7. 2010
    ....
  13. pmc Evolutionary study of a potential selection target region in the pig
    A Ojeda
    Facultat de Veterinaria, Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Heredity (Edinb) 106:330-8. 2011
    ..of ∼500 bp equally spaced in a 2 Mb region in the vicinity of the FAT1 region in a wide-diversity panel of 32 pigs. Asian and European animals, including local Mediterranean and international pig breeds, were sequenced...
  14. pmc Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion
    John C Schwartz
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Immunogenetics 64:303-11. 2012
    ..The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other ..
  15. doi Susceptibility of piglets to enterotoxigenic Escherichia coli is not related to the expression of MUC13 and MUC20
    M Schroyen
    Livestock Genetics, Department Biosystems, KULeuven, Heverlee, Belgium
    Anim Genet 43:324-7. 2012
    ..Economically, the swine industry is by far the most affected by infections with ETEC because of mortality, morbidity and decreased growth ..
  16. pmc Contrasting mode of evolution at a coat color locus in wild and domestic pigs
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000341. 2009
    ..diversity at the porcine melanocortin receptor 1 (MC1R) locus, we provide evidence that wild and domestic pig (Sus scrofa) haplotypes from China and Europe are the result of strikingly different selection pressures, and that coat ..
  17. doi Intestinal expression of TFF and related genes during postnatal development in a piglet probiotic trial
    Jutta Scholven
    Freie Universitat Berlin, Institute of Veterinary Biochemistry, Berlin, Germany
    Cell Physiol Biochem 23:143-56. 2009
    ..However, a feed supplementation with the probiotic strain Enterococcus faecium did not influence TFF expression...
  18. pmc Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
    Bodil Gesslein
    Department of Ophthalmology, Lund University, Lund, Sweden
    Mol Vis 16:392-407. 2010
    ..The aim of the present study was to examine changes in the expression of intracellular signal-transduction pathways, specifically mitogen-activated protein kinases, following retinal ischemia-reperfusion...
  19. ncbi Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner
    Margaret M Joyce
    Center for Animal Biotechnology and Genomics, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 148:4420-31. 2007
    ..in response to day of pregnancy, estrogen injection, and intrauterine infusion of conceptus secretory proteins in pigs indicated 1) estrogen increases STAT1 in luminal epithelial cells, 2) conceptus secretory proteins that contain ..
  20. doi The chromosomal localization, expression pattern and polymorphism analysis of porcine FSCN1 gene differently expressed from LongSAGE library
    Zh L Tang
    Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, People s Republic of China
    Mol Biol Rep 37:2361-7. 2010
    ..prenatal skeletal muscle development and exhibited different expression pattern between Tongcheng and Landrace pigs. In Tongcheng pigs, FSCN1 expression was similar at 33 and 65 days post conception (dpc), and then sharply ..
  21. doi In vivo forced expression of myocardin in ventricular myocardium transiently impairs systolic performance in early neonatal pig heart
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, Spain
    Int J Dev Biol 53:1457-67. 2009
    ..Extended analysis on day 7 post-delivery revealed a drop decrease in myocd-A transgene expression in target LVFW regions which was correlated with normalization of the LV systolic parameters in experimented piglets...
  22. doi Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets
    Lu Liu
    Key Laboratory for Animal Genetics, Department of Animal Genetics, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, PR China
    Gene 523:70-5. 2013
    ..The AA genotype for the HpaII site in exon 10 of the porcine BPI gene was demonstrated to be an anti-ETEC F18 marker and could be used for selective breeding to enhance ETEC F18 resistance...
  23. doi Dynamic changes in TAP1 expression levels in newborn to weaning piglets, and its association with Escherichia coli F18 resistance
    J Wang
    College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, China
    Genet Mol Res 13:3686-92. 2014
    ..The high expression level of TAP1 indicated that the gene might play an important role in Escherichia coli F18 resistance. ..
  24. pmc Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs
    Jun Ren
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, People s Republic of China
    PLoS ONE 7:e44573. 2012
    Enterotoxigenic Escherichia coli (ETEC) F4ac is a major determinant of diarrhea and mortality in neonatal and young pigs. Susceptibility to ETEC F4ac is governed by the intestinal receptor specific for the bacterium and is inherited as a ..
  25. doi Expression of leptin and its receptor genes in the ovarian follicles of cycling and early pregnant pigs
    N Smolinska
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Poland
    Animal 7:109-17. 2013
    ..The differences in OB-Rb gene expression in porcine GC and theca cells also suggest that their sensitivity to leptin varies in the ovaries of pregnant and cyclic pigs.
  26. ncbi The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence
    Cord Drogemuller
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, 30559, Germany
    Mamm Genome 17:58-66. 2006
    ..similar mouse coat color mutants, it seems therefore conceivable that the black-and-tan pigmentation of Mangalitza pigs is caused by an ASIP allele a(t), which is recessive to the wild-type allele A...
  27. ncbi Expression of the vascular endothelial growth factor-receptor system in the porcine endometrium throughout the estrous cycle and early pregnancy
    Monika M Kaczmarek
    Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    Mol Reprod Dev 75:362-72. 2008
    ..insert domain-containing receptor, Flk-1/KDR) in the endometrium during the estrous cycle and early pregnancy in pigs. The VEGF-receptor system was localized in epithelial and stromal cells, blood vessels, and myometrium...
  28. pmc Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain
    Sandrine Belouzard
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:22758-63. 2010
    ..We propose a novel mechanism whereby SARS-CoV fusion protein function can be controlled by spatial regulation of the proteolytic priming site, with important implications for viral pathogenesis...
  29. doi Porcine S100A8 and S100A9: molecular characterizations and crucial functions in response to Haemophilus parasuis infection
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China
    Dev Comp Immunol 35:490-500. 2011
    ..Interestingly, the maximum increase of mRNA levels in blood cultures of Meishan pigs is significantly greater than that in Duroc pigs...
  30. pmc New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs
    Annie Robic
    INRA, UMR444, Laboratoire de Genetique Cellulaire, 31326 Castanet Tolosan, France
    Genet Sel Evol 43:15. 2011
    ..is located in a region where a QTL influencing boar fat androstenone levels has been detected in a Large White pig population...
  31. pmc Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    PLoS ONE 6:e26392. 2011
    ..However, the molecular and functional consequences of myocd upregulation in HF are still unclear...
  32. doi Age-dependent expression of the BPI gene in Sutai piglets
    J Zhu
    College of Animal Science and Technology, Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, China
    Genet Mol Res 12:2120-6. 2013
    ....
  33. doi Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance
    A Gonzalez-Bulnes
    Departamento de Reproduccion Animal, Instituto Nacional de Investigaciones Agrarias, 28040 Madrid, Spain
    Gen Comp Endocrinol 176:94-101. 2012
    The current study was conducted in a swine breed (Iberian pig) with a genotype that predisposed the pig to obesity...
  34. pmc The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs
    Anna Granlund
    Department of Clinical Sciences, Section for Comparative Physiology and Medicine, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, SE 750 07, Uppsala, Sweden
    Acta Vet Scand 53:20. 2011
    ..Many pigs of Hampshire origin have a naturally occurring dominant mutation in the AMPK γ3 subunit...
  35. ncbi Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons
    V Amarger
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Cytogenet Genome Res 102:163-72. 2003
    ..missense mutation in the PRKAG3 gene causes a dominant phenotype involving abnormally high glycogen content in pig skeletal muscle...
  36. doi Functional analysis of the porcine USP18 and its role during porcine arterivirus replication
    Tahar Ait-Ali
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Gene 439:35-42. 2009
    ..Little is known about deubiquitylation in pig and arterivirus infection...
  37. doi Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle
    Ozlem Aslan
    Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland
    Mol Biol Rep 39:4101-10. 2012
    ..in the insulin-like growth factor 2 gene (IGF2) has been associated with a desirable reduction in BF depth in pigs. Given that the lipid metabolism of intramuscular adipocytes differs from that of subcutaneous fat adipocytes, this ..
  38. ncbi The sequence of porcine apolipoprotein E (APOE) cDNA
    A Brzozowska
    Department of Animal Science, Agricultural University, As, Norway
    DNA Seq 4:207-10. 1993
    ..The porcine APOE cDNA sequence is 1122 bp in length and encodes a pre-protein of 317 amino acids. The inferred porcine amino acid sequence corresponds to the human APOE-4 isoform...
  39. ncbi Sialomucin complex (Muc4) expression in porcine endometrium during the oestrous cycle and early pregnancy
    A D Ferrell
    Department of Animal Science, Oklahoma Agriculture Experiment Station, Oklahoma State University, Stillwater, OK 75078 6051, USA
    Reprod Domest Anim 38:63-5. 2003
    The non-invasive type of implantation in the pig is characterized by the maintenance of a thick glycocalyx coating on the uterine epithelial surface microvilli...
  40. ncbi Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gsalpha functions
    Marie Morikawa
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
    J Reprod Dev 53:1151-7. 2007
    ....
  41. doi Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro
    Mario Torrado
    Institute of Health Sciences, University of La Coruna, Spain
    Exp Biol Med (Maywood) 235:941-51. 2010
    ..The pig DeltaE2-NPPB mRNA is effectively translated into stable protein in cell-based assays but, in contrast to normally ..
  42. doi Evidence for expression of relaxin hormone-receptor system in the boar testis
    Shinichi Kato
    Laboratory of Animal Reproduction and Physiology, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga, Shizuoka City, Shizuoka 422 8529, Japan
    J Endocrinol 207:135-49. 2010
    ..Thus, we provide evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testis act as a source and possible target tissue of RLN...
  43. ncbi Sequence of the swine major histocompatibility complex region containing all non-classical class I genes
    P Chardon
    Laboratoire de Radiobiologie et Etude du Génome, INRA CEA, Jouy en Josas, France
    Tissue Antigens 57:55-65. 2001
    ..conserved in the SLA and HLA complexes, except for the SC1 gene which displayed a shift of the reading frame in swine. The cluster of the three SLA class I-related genes (Ib) and the MIC1 and MIC2 genes were located in the middle of ..
  44. ncbi Characterization of porcine dentin sialoprotein (DSP) and dentin sialophosphoprotein (DSPP) cDNA clones
    Yasuo Yamakoshi
    University of Michigan Dental Research Laboratory, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 111:60-7. 2003
    ..We have constructed and screened a unidirectional cDNA library derived from the pulp organ of developing pig teeth, and isolated cDNA clones encoding DSP-only, as well as two DSPP clones with alternative sequences in their 3'..
  45. doi Cloning and spatio-temporal expression of porcine CDK5 and CDK5R1(p35) genes
    Huan Long
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, P R China
    Anim Biotechnol 20:133-43. 2009
    ..In the present study, the full-length coding regions of CDK5 and CDK5R1 were cloned from pigs. Radiation hybrid mapping localized porcine CDK5 to chromosome 18q12-13, whereas CDK5R1 was electro-localized to ..
  46. pmc Melanocortin receptor 1 (MC1R) mutations and coat color in pigs
    J M Kijas
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24, Uppsala, Sweden
    Genetics 150:1177-85. 1998
    ..The European wild boar possessed a unique MC1R allele that we believe is required for the expression of a wild-type coat color...
  47. ncbi A mapping and evolutionary study of porcine sex chromosome genes
    Claire R Quilter
    Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mamm Genome 13:588-94. 2002
    A combination of FISH and RH mapping was used to study the evolution of sex chromosome genes in the pig. In total, 19 genes were identified, including 3 PAR genes (STS, KAL, PRK)...
  48. ncbi Identification and characterization of novel peroxisome proliferator-activated receptor-gamma (PPAR-gamma) transcriptional variants in pig and human
    T Omi
    Swiss Federal Institute of Technology, Institute of Animal Sciences, Zurich, Switzerland
    J Anim Breed Genet 122:45-53. 2005
    ..To date, two major PPAR-gamma isoforms have been identified in pig, PPAR-gamma1 and PPAR-gamma2...
  49. ncbi Sources and biological actions of relaxin in pigs
    C A Bagnell
    Department of Animal Sciences, Rutgers University, New Brunswick, NJ 08903
    J Reprod Fertil Suppl 48:127-38. 1993
    ..Uterotrophic effects of relaxin have been reported in rodents and swine and support the hypothesis that relaxin promotes uterine growth and expansion in early pregnancy to accommodate ..
  50. ncbi Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid
    N Okamura
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 1336:99-109. 1997
    ..The possibilities have been discussed that it protects sperm from the premature acrosome reaction and maintains sperm fertilizing ability in the epididymis...
  51. ncbi Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase
    H Postlind
    Department of Pharmaceutical Biosciences, University of Uppsala, Sweden
    Biochem Biophys Res Commun 241:491-7. 1997
    ..activation of vitamin D3 into its hormonal form 1 alpha,25-dihydroxyvitamin D3 has earlier been purified from pig liver...
  52. ncbi Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis
    H J Nauwynck
    Laboratory of Veterinary Virology, Faculty of Veterinary Medicine, University of Gent, Merelbeke, Belgium
    J Gen Virol 80:297-305. 1999
    ..A subsequent drop in pH is required for proper virus replication...
  53. ncbi Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2
    L Badinga
    Interdisciplinary Concentration in Animal Molecular and Cell Biology, Department of Animal Science, University of Florida, Gainesville, Florida 32611, USA
    J Mol Endocrinol 23:277-85. 1999
    ....
  54. ncbi Primary structure and functional characterization of a soluble, alternatively spliced form of B7-1
    S J Faas
    Alexion Pharmaceuticals, New Haven, CT 06511, USA
    J Immunol 164:6340-8. 2000
    ..that porcine B7-1 interacts with the human receptors CD28 and CTLA-4, suggesting a potential role for this molecule in pig to human xenotransplantation. Possible physiological functions for the soluble form of B7-1 are discussed.
  55. ncbi Normalized cDNA libraries from a porcine model of orthopedic implant-associated infection
    Anette Rink
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
    Mamm Genome 13:198-205. 2002
    ..PBC), spleen (Sp), thymus (Th), lymph node (LN), and bone marrow (BM) from immunologically naive and challenged pigs as part of an implant-associated orthopedic model of deep infection...
  56. ncbi Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
    Valerie Amarger
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, SE 751 24 Uppsala, Sweden
    Mamm Genome 13:388-98. 2002
    IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development...
  57. pmc The porcine major histocompatibility complex and related paralogous regions: a review
    P Chardon
    Laboratoire de Radiobiologie et d Etude du Génome, Département de Génétique Animale, Institut National de la Recherche Agronomique, Commissariat a l Energie Atomique, 78352, Jouy en Josas Cedex, France
    Genet Sel Evol 32:109-28. 2000
    ..In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced...
  58. ncbi In vitro differentiation of porcine blood CD163- and CD163+ monocytes into functional dendritic cells
    Sonia Chamorro
    Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Ctra de La Coruna, km 7 5, 28040 Madrid, Spain
    Immunobiology 209:57-65. 2004
    b>Swine monocytes constitute a heterogeneous cell population containing subsets with distinct functional capacities or representing different maturational stages...
  59. ncbi Effect of relaxin on acrosome reaction and utilization of glucose in boar spermatozoa
    A G Miah
    Laboratory of Animal Biotechnology, Interdisciplinary Graduate School of Science and Technology, Shinshu University, Minamiminowa mura, Nagano, Japan
    J Reprod Dev 52:773-9. 2006
    ..In conclusion, the present study demonstrates that relaxin accelerates not only motility but also the acrosome reaction and utilization of glucose in boar spermatozoa...
  60. pmc Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)
    Satoshi Mikawa
    Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Genome Res 17:586-93. 2007
    ..We previously identified two quantitative trait loci (QTL) for the number of vertebrae on Sus scrofa chromosomes (SSC) 1 and 7. These QTL explained an increase of more than two vertebrae...
  61. ncbi Long form of leptin receptor gene and protein expression in the porcine ovary during the estrous cycle and early pregnancy
    Nina Smolinska
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10 719 Olsztyn Kortowo, Oczapowskiego 1A, Poland
    Reprod Biol 7:17-39. 2007
    ..In summary, the obtained results indicate that leptin may participate in the control of pig reproduction at the ovarian level and have a direct effect on the ovary during both, the luteal phase of the cycle ..
  62. pmc Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity
    Philippe G A C Vanden Bergh
    Department of Pathology, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Vet Res 40:33. 2009
    ..Recently, we showed that ApxIIIA-cytotoxic activity specifically targets Sus scrofa leukocytes...
  63. doi Immunohistochemical localization of protein kinase C-alpha in the retina of pigs during postnatal development
    Meejung Ahn
    Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju 690 756, South Korea
    Neurosci Lett 455:93-6. 2009
    ..3-day-old piglets and indicated significantly increased expression in 6-month-old young adult and 2-year-old adult pigs. Immunohistochemistry of 3-day-old retinas revealed intense PKC-alpha reactivity in the inner plexiform and inner ..
  64. doi Fine mapping of quantitative trait loci for meat color on Sus scrofa chromosome 6: analysis of the swine NUDT7 gene
    M Taniguchi
    Animal Genome Research Unit, National Institute of Agrobiological Sciences, Ibaraki 305 0901, Japan
    J Anim Sci 88:23-31. 2010
    ..Our previous analyses of a whole genome QTL scan for various meat qualities using 2 F(2) families from Japanese wild boar (known as a red meat) x Large White and from Duroc x Chinese Jinhua suggested that a meat color (heme content) ..
  65. pmc The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner
    Wander Van Breedam
    Laboratory of Virology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Pathog 6:e1000730. 2010
    The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today...
  66. pmc Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway
    Tomoyuki Shimazu
    Food Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Infect Immun 80:276-88. 2012
    ....
  67. doi Investigation on the transcription factors of porcine 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase genes
    Xinxing Dong
    College of Animal Science and Technology, China Agricultural University, 100094 Beijing, China
    Gene 499:186-90. 2012
    ..Our study gives new insights to the transcriptional regulation of 3βHSD1 and 17βHSD7 and further hints to their involvement in steroid metabolism...
  68. ncbi Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV
    B Delmas
    Unite de Virologie et Immunologie Moleculaires, INRA, Jouy en Josas, France
    Nature 357:417-20. 1992
    ..Transmissible gastroenteritis virus (TGEV), a major pathogen causing a fatal diarrhoea in newborn pig, replicates selectively in the differentiated enterocytes covering the villi of the small intestine...
  69. ncbi Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins
    M Muller
    Department of Molecular Animal Breeding, Munich, FRG
    J Interferon Res 12:119-29. 1992
    ..The Mx family shows in their amino termini striking homology to previously characterized Mx-related proteins playing roles in the intracellular vectorial transport of proteins--the products of the yeast Vps1 locus and the dynamins...
  70. ncbi Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia
    J Fujii
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Science 253:448-51. 1991
    ..MH) causes neurological, liver, and kidney damage and death in humans and major economic losses in the swine industry...
  71. ncbi Isolation and genetic characterization of the porcine apolipoprotein E gene
    J J Ramsoondar
    Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine and Center for Animal Genetics, Texas A and M University, College Station 77843 4458, USA
    Anim Genet 29:43-7. 1998
    ..Finally, localization of the porcine apo-E gene to chromosome 6 band q2.1 was determined by fluorescent in situ hybridization and confirmed by genetic linkage analysis...
  72. ncbi A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1
    B Alvarez
    Centro de Investigacion en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain
    Tissue Antigens 55:342-51. 2000
    SWC3 was defined at the First International Swine CD Workshop as a specific myelomonocytic antigen of 230 kDa with mAbs 74-22-15, 6F3 and DH59B...
  73. ncbi Integration of porcine chromosome 13 maps
    M Van Poucke
    Department of Animal Nutrition, Genetics, Breeding and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Cytogenet Cell Genet 93:297-303. 2001
    ..This integrated map will give us the opportunity to take maximal advantage of the comparative mapping strategy for positional candidate cloning of genes responsible for economically important traits...
  74. ncbi A calcium-driven conformational switch of the N-terminal and core domains of annexin A1
    Anja Rosengarth
    UCI Program in Macromolecular Structure, Department of Molecular Biology and Biochemistry, University of California, 3205 McGaugh Hall, Irvine, CA 92797 3900, USA
    J Mol Biol 326:1317-25. 2003
    ..Possible implications of this calcium-induced conformational switch for the membrane aggregation properties of annexin A1 will be discussed...
  75. ncbi Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Bldg El Fortín, As Xubias s n, 15006, La Coruna, Spain
    J Mol Med (Berl) 81:566-77. 2003
    ..The study revealed the following novel findings: (1) myocardin transcripts are detected in neonatal human and pig hearts at lower levels than in mature cardiac tissues, (2) the myocardin transcript pool is significantly augmented ..
  76. ncbi Developmental expression of 2489 gene clusters during pig embryogenesis: an expressed sequence tag project
    Kristin Whitworth
    Department of Animal Science, University of Missouri Columbia, Columbia, MO 65211, USA
    Biol Reprod 71:1230-43. 2004
    ..This is the first large-scale sequencing project on early pig embryogenesis and has resulted in the discovery of a large number of genes as well as possible stage-specific ..
  77. ncbi Functional consequences of the oligomeric form of the membrane-bound gastric H,K-ATPase
    Jai Moo Shin
    Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA jaishin ucla edu
    Biochemistry 44:16321-32. 2005
    ..It appears that the catalytic subunits of the oligomer during turnover in intact gastric vesicles are restricted to a reciprocal E(1):E(2) configuration...
  78. ncbi Molecular characterization of the porcine surfactant, pulmonary-associated protein C gene
    S Cirera
    Department of Animal and Veterinary Basic Sciences, Division of Genetics, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
    Genomics 88:659-68. 2006
    ..were detected mainly in lung by real-time RT-PCR and they were significantly down-regulated in necrotic lungs of pigs infected with Actinobacillus pleuropneumoniae...
  79. ncbi Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa)
    Xinyun Li
    Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China
    Comp Biochem Physiol B Biochem Mol Biol 147:271-7. 2007
    ..Moreover, we found that one single nucleotide polymorphism (SNP, T/C(70)) in the ninth intron of ADSS2 gene was significantly associated with average daily gain trait (ADG, P<0.05) and loin muscle area trait (P<0.05)...
  80. ncbi Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line
    Masayuki Moue
    Food Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aobaku, Sendai 981 8555, Japan
    Biochim Biophys Acta 1780:134-44. 2008
    ..originally established porcine intestinal epitheliocyte (PIE) cells were treated with lipopolysaccharide (LPS) or swine-specific enterotoxigenic Escherichia coli (ETEC)...
  81. doi Genetic variation in the mannosidase 2B2 gene and its association with ovulation rate in pigs
    E M Campbell
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    Anim Genet 39:515-9. 2008
    Ovulation rate is an important phenotypic trait that is a critical component of litter size in pigs. Despite being moderately heritable in pigs, selection for increased ovulation rate is difficult because it is difficult to measure and is ..
  82. doi The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
    Anim Biotechnol 20:58-70. 2009
    ..Here, the FTO gene was studied as a candidate gene for fatness and growth rate traits in pigs. The amino acid sequence of the FTO gene showed high conservation among human, pig, and other important domestic ..
  83. doi Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs
    Luca Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
    Mol Biol Rep 37:461-6. 2010
    ..276T > G) is associated with fat deposition traits in pigs. To confirm this result, we genotyped this polymorphism in an Italian Duroc population made up by 313 performance ..
  84. doi Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface
    Dana A Massuto
    Departments of Veterinary Integrative Biosciences Veterinary Large Animal Clinical Sciences Animal Science, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 139:465-78. 2010
    ..at the conceptus-maternal interface to mediate events essential for conceptus development and attachment in pigs. Uteri and conceptuses from days 10, 12, 16, 20, and 24 pregnant gilts were immunostained for TGFB, LAP, and ITG ..
  85. doi Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Pediatr Res 67:250-6. 2010
    ..The aim was to study changes in oxidative stress-associated markers in liver and lung tissue of newborn pigs after acute hypoxia followed by reoxygenation for 30 min with 21, 40, or 100% oxygen compared with room air or to ..
  86. doi Identification, bioinformatic analysis and expression profiling of candidate mRNA-like non-coding RNAs in Sus scrofa
    Bang Xiao
    Huazhong Agricultural University, Wuhan, China
    J Genet Genomics 36:695-702. 2009
    ..The predicted pre-microRNA sequence in this study provides a potentially interesting insight into the in vivo function of porcine mlncRNAs and our findings suggest that they play key biological roles in Sus scrofa.
  87. pmc A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs
    J Ren
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Meiling Road, Nanchang, PR China
    Heredity (Edinb) 106:862-8. 2011
    Brown coat colour has been described in Chinese-Tibetan, Kele, and Dahe pigs. Here, we report the identification of a causal mutation underlying the brown colouration...
  88. doi Toll-like receptor 4 polymorphism impairing lipopolysaccharide signaling in Sus scrofa, and its restricted distribution among Japanese wild boar populations
    Hiroki Shinkai
    Agrogenomics Research Center, National Institute of Agrobiological Sciences NIAS, Ibaraki, Japan
    DNA Cell Biol 31:575-81. 2012
    ..We previously found seven amino acid polymorphisms in Sus scrofa TLR4...
  89. doi Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway
    Jun Hou
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Virus Res 167:106-11. 2012
    ..Taken together, our results indicated that HP-PRRSV infection could impair TNF-α production by inhibiting ERK signaling pathway, which might partially contribute to the pathogenesis of HP-PRRSV...
  90. doi Transcript variants of the porcine glucocorticoid receptor gene (NR3C1)
    Henry Reyer
    Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Gen Comp Endocrinol 189:127-33. 2013
    ..of alternative processing of NR3C1 in mammalian species and to facilitate future studies of its regulation in the pig we explored here structural diversity, and tissue-specific distribution of transcript variants of the porcine NR3C1,..
  91. doi RAG1/2 knockout pigs with severe combined immunodeficiency
    Jiao Huang
    Laboratory of Animal Cloning, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
    J Immunol 193:1496-503. 2014
    b>Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research...
  92. ncbi Evidence for linkage between K88ab, K88ac intestinal receptors to Escherichia coli and transferrin loci in pigs
    G Guerin
    Laboratoire de Génétique Biochimique, INRA CRJ, Jouy en Josas, France
    Anim Genet 24:393-6. 1993
    ..coli adhesins (K88abR, K88acR) and at the transferrin (TF) locus was studied in 38 pig families including 273 piglets...
  93. ncbi Amino acid sequence of a porcine zona pellucida glycoprotein ZP4 determined by peptide mapping and cDNA cloning
    A Hasegawa
    Department of Obstetrics and Gynecology, Hyogo Medical College, Nishinomiya, Japan
    J Reprod Fertil 100:245-55. 1994
    ..These results suggest that porcine ZP4 and ZP2 are derived from a common parent polypeptide by proteolytic cleavage at the position between 133 and 134 residues...
  94. ncbi Porcine SRY gene locus and genital ridge expression
    I Daneau
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, Quebec, Canada
    Biol Reprod 55:47-53. 1996
    ..locus was cloned through use of a strategy of anchored polymerase chain reaction (PCR) amplification from a male pig genomic DNA size-selected library constructed in a plasmid vector as well as 3' reverse transcription (RT)-PCR ..
  95. ncbi Porcine caspase-3: its cloning and activity during apoptosis of PK15 cells induced by porcine Fas ligand
    Y Muneta
    Institute of Animal Health, Tsukuba, Ibaraki, 305 0856, Japan
    J Interferon Cytokine Res 21:409-15. 2001
    ..The porcine caspase-3 cDNA isolated in this study will be useful for the study of apoptotic cell death in pigs and will lead to the discovery of therapeutic uses of caspases and their inhibitors in the prevention of viral and ..
  96. ncbi Construction of a 1.2-Mb BAC/PAC contig of the porcine gene RYR1 region on SSC 6q1.2 and comparative analysis with HSA 19q13.13
    Flávia Martins-Wess
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, Hannover, Germany
    Genomics 80:416-22. 2002
    ..2. This genomic segment is of special interest because it harbors the locus for stress susceptibility in pigs and a putative quantitative trait locus for muscle growth...
  97. ncbi Generation and sequence characterization of a normalized cDNA library from swine ovarian follicles
    Alexandre R Caetano
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska, 68583 0908, USA
    Mamm Genome 14:65-70. 2003
    Ovulation rate is a major factor determining litter size in swine and is, therefore, a trait of economic importance to the pork industry...
  98. ncbi Detection of quantitative trait loci for fat androstenone levels in pigs
    R Quintanilla
    Institut National de la Recherche Agronomique, France
    J Anim Sci 81:385-94. 2003
    A QTL analysis of fat androstenone levels from a three-generation experimental cross between Large White and Meishan pig breeds was carried out...
  99. pmc Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages
    Nathalie Vanderheijden
    Laboratory of Virology, Faculty of Veterinary Medicine, Flanders Interuniversity Institute of Biotechnology VIB, 5830 AA Boxmeer, The Netherlands
    J Virol 77:8207-15. 2003
    ..It shared 69 and 78% amino acid identity, respectively, with mouse and human sialoadhesins. Swine (PK-15) cells resistant to viral entry were transfected with the cloned p210 cDNA and inoculated with European or ..
  100. ncbi Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection
    C Sanchez-Torres
    Dpto Biotecnología, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Ctra de La Coruña Km 7 5, 28040 Madrid, Spain
    Arch Virol 148:2307-23. 2003
    Monocytes-macrophages, the target cells of African swine fever virus (ASFV) are highly heterogeneous in phenotype and function...
  101. ncbi The mechanism of myosin VI translocation and its load-induced anchoring
    David Altman
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    Cell 116:737-49. 2004
    ..From our results, we propose a mechanism of myosin VI stepping that predicts a regulation through load of the motor's roles as transporter and anchor...

Research Grants115 found, 100 shown here

  1. BONE MARROW CULTURE AND ENGRAFTMENT IN A SWINE MODEL
    David Sachs; Fiscal Year: 1999
    ..The miniature swine model has several advantages over other large animal models for this purpose, including defined transplantation ..
  2. High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
    Randall S Prather; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The current methods for cryopreservation of swine embryos are time consuming and troublesome...
  3. Screen for Identification of Important Human Birth Defect Models in Swine
    Kate G Ackerman; Fiscal Year: 2010
    ..This proposal seeks to identify naturally occurring genetic swine models for specific birth defects for which large animal models are needed...
  4. Xiankai Sun; Fiscal Year: 2014
    ..Aim 3: To longitudinally monitor the dynamic BCM change in T2D Ossabaw swine and assess the potential toxic effect of the longitudinal imaging procedure...
  5. Development of Ultrafine Particles for Intranasal Delivery of Antipsychotics
    SANDRA EDITH NORIEGA; Fiscal Year: 2013
    ..In vitro drug release examinations will be complemented by muco-adhesive tests, and ex vivo (swine nasal membrane) drug permeation studies...
  6. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  7. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
    ..and Immunology of the Institute for Animal Health, England, where I studied the intracellular transport of African swine fever virus, a large DNA virus. My work led to the publication of 3 first-author papers...
  8. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Most recently, this system was used to diagnosis the first swine H1N1 2009 cases in the United States...
  9. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Also swine metabolize retinol comparable to humans...
  10. DOROTHY EILEEN VATNER; Fiscal Year: 2014
    ..mechanisms of cardiac protection in the second window of ischemic protection in chronically instrumented conscious swine. The project is based, in part, on the novel observation that either regional cardiac denervation or adrenergic ..
  11. Mathematical Modeling of Inflammation in ARDS
    Gary F Nieman; Fiscal Year: 2010
    ..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...
  12. Prevalance of Community-Acquired MRSA in Live Pigs and thier Human Handlers
    LYNDA UJU ODOFIN; Fiscal Year: 2010
    ..Lt will determine if a strain of swine origin exists, and also explore the necessity and feasibility of implementing a nation-wide farm screening scheme ..
  13. Mathematical Modeling of Inflammation in ARDS
    Yoram Vodovotz; Fiscal Year: 2010
    ..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...
  14. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..amp;amp;control</keyword;keyword>*Stem Cell Transplantation</keyword;keyword>Swine</keyword;/keywords;dates;year>2000</year;pub-dates;date>Jun</date;/pub-dates;/dates;accession-num&..
  15. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..The 2009 Influenza A/H1N1, or "swine flu," pandemic occupied the time and attention of many...
  16. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..the following specific aims: Specific Aim 1: to genetically enhance endothelial progenitor cells, isolated from swine peripheral blood, by over-expressing the anticoagulant and anti-inflammatory protein thrombomodulin (TM) before ..
  17. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..There are also a number of emerging viruses such as West Nile and the breaking Mexican swine flu, and a number of potential bioterrorism pathogens such as smallpox that are of concern to the safety of the ..
  18. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..this system in an ex vivo perfusion circuit;and 4) evaluate the liquid cast NO-eluting PDC stent system in a swine model of atherosclerosis to evaluate the in vivo polymerization of the device as well as overall outcome...
  19. Renovations of the Animal Care Facility
    AWADH AMIR BINHAZIM; Fiscal Year: 2010
    ..Currently the ACF houses mice, rats, rabbits, guinea pigs, and swine. Use of the facility has increased considerably in recent years: in 2007-2008, there were 27 investigators ..
  20. Construct novel influenza A (H1N1) virus chimeric HA genes for development of bro
    VICTOR CHESTER HUBER; Fiscal Year: 2010
    ..The recent emergence and pandemic classification of novel swine-origin influenza A H1N1 virus, 2009 A (H1N1) poses a significant threat to public health...
  21. Walter Newman; Fiscal Year: 2014
    ..Studies described in the application will extend our testing of the inhibitors to a swine model of acute myocardial infarction.
  22. Development of Porcine Genetic Models of Atherosclerosis
    SCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Because the cardiovascular anatomy of swine is similar to humans with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine ..
  23. A Novel Therapy for Septic Shock
    Xiaoling Qiang; Fiscal Year: 2011
    ..pharmacokinetic properties of rhMFG-E8 in normal and septic animals;and 5) determine the efficacy of rhMFG-E8 in a swine model of septic shock...
  24. Stimulation of broadly neutralizing antibodies against influenza in a pig model
    RADHEY SHYAM KAUSHIK; Fiscal Year: 2011
    ..approached by an interdisciplinary team that consists of David Francis (Co-PI, Pig model), Radhey Kaushik (Co-PI, swine immunology), Feng Li (Investigator, influenza virology) and two swine influenza consultants (Weijun Ma and Mahesh ..
  25. Rational design of M2e-FP conserved epitope-based universal influenza A vaccines
    Lanying Du; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The recent global outbreak of influenza A caused by a novel swine-origin H1N1 influenza A virus (S-OIV) has led to a growing concern regarding the pandemic potential of the highly pathogenic avian ..
  26. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..The proposed studies will be performed on Ossabaw swine fed a normal maintenance diet (7% kcal from fat) or an atherogenic diet (45% kcal from fat and 2% cholesterol) for ..
  27. TRANSMISSION OF OSELTAMIVIR-RESISTANT INFLUENZA A H1N1 VIRUSES IN GUINEA PIGS
    Nicole M Bouvier; Fiscal Year: 2012
    ..The use of oseltamivir has dramatically increased during the current swine-origin A/H1N1 pandemic [72];this has in turn increased the chances of selecting resistant viruses in novel A/H1N1-..
  28. Jianyi Zhang; Fiscal Year: 2016
    ..We have recently established a population of multipotent adult progenitor cells from swine bone marrow (sMPC) that can proliferate for >100 population doublings, and differentiate at the single cell ..
  29. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ..facilitates extrapolating our findings to humans and prevents interference and confounding factors from wild swine rotavirus contaminations...
  30. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..As pilot studies by our group have documented the presence of MRSA in US swine, we seek to expand upon this research and examine the epidemiology of Staphylococcus aureus more broadly in ..
  31. Impact of Atrial Fibrillation and Surgical Ablation on Atrial Function
    JASON OWEN ROBERTSON; Fiscal Year: 2012
    ..A Hanford mini-swine model of persistent AF will be employed whereby the animals will be atrially paced at 400 bpm with the ventricular ..
  32. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..The IRES of classical swine fever virus, a pestivirus, is substantially resistant to inhibition by eIF2 phosphorylation, which can be ..
  33. John M Canty; Fiscal Year: 2014
    ..To ultimately enhance translation, studies will be conducted in swine with a heart size similar to humans...
  34. Hepatic Insulin Gene Therapy in Swine
    Peter M Thule; Fiscal Year: 2013
    ..b>Swine are a more accurate model of human responses to diabetes mellitus than rodents...
  35. David M Roth; Fiscal Year: 2016
    ..determine if gene transfer of Cav-3 modulates ANP and shows efficacy in a preclinical model of heart failure in swine. State of the art molecular and physiological techniques will be used in the studies in clinically relevant models ..
  36. Edward O McFalls; Fiscal Year: 2016
    ..Our group has successfully established a reproducible swine model of hibernating myocardium and has studied this model extensively...
  37. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    ..In preliminary investigations performed on swine, T1A was shown to detect changes to the overall apparent exchange rate and rate of relaxation caused by rotational ..
  38. Amit Joshi; Fiscal Year: 2014
    ..The developed system and methods will be validated on a clinically relevant Swine based animal model for detecting lymph node locations in three dimensions, following microdose intradermal ..
  39. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..Importantly, however, novel imaging techniques for studying the myocardial microcirculation, and swine models that mimic human cardiovascular physiology and pathophysiology, now provide a unique opportunity to ..
  40. Stem Cell Based Therapy for Regenerative Endodontics
    George T J Huang; Fiscal Year: 2013
    ..Aim 3- To test pulp regeneration in a relevant tissue environment in swine. This experimental swine model simulates actual clinical applications in humans using autologous stem cells for ..
  41. Immune factors in vaccine-enhanced pandemic H1N1 influenza disease
    Amy L Vincent; Fiscal Year: 2013
    ..A similar phenomenon of enhanced disease is observed in pigs after vaccination with an inactivated H1 swine influenza virus, followed by heterologous panH1N1 challenge...
  42. Exercise, Diabetes, &Coronary Smooth Muscle Ca2+
    Michael Sturek; Fiscal Year: 2013
    ..e. peri-stent CAD. Major findings in our previous grant provide outstanding rationale for this project. Ossabaw swine have clinically significant atherosclerosis (>50% stenosis) and we have for the first time stented natural ..
  43. ALEJANDRO ROBERTO CHADE; Fiscal Year: 2015
    ..We have developed a swine model of RAS that closely mimics the renal functional and structural changes that occur in humans with RAS, ..
  44. HEATHER MICHELLE FRITZ; Fiscal Year: 2015
    ..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
  45. ROBERT MICHAEL ROBERTS; Fiscal Year: 2016
    ..Such chimeras may also be valuable as an alternative to cloning for creating genetically modified swine. Aim 2 is to determine whether or not the various LIF-and FGF2-dependent piPSC at our disposal are superior donors ..
  46. W M BUJALOWSKI; Fiscal Year: 2016
    ..Mammalian Polymerase ? (pol ?) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA ..
  47. Maja Nowakowski; Fiscal Year: 2015
    ..S. Army) in the swine model, have established the remarkable sealing properties of the agent...
  48. Susceptibility and Protective Immunity to Noroviruses
    Ralph S Baric; Fiscal Year: 2013
    ..4 challenge model in swine and characterizes human monoclonal antibodies (mAb) to GI and GII strains, providing key reagents for advancing ..
  49. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The ability to efficiently modify the swine genome to generate genetically modified animals has the potential to provide a novel source of cells/tissues for clinical applications...
  50. BRIAN RAYMOND WEIL; Fiscal Year: 2015
    ..the capacity of each cell population to elicit improvements in myocardial contractile function and perfusion in swine with hibernating myocardium resulting from a chronic coronary stenosis...
  51. Johnathan D Tune; Fiscal Year: 2016
    ..first evidence for impaired myocardial GLP-1 responses in the setting of the obese-metabolic syndrome (MetS) in swine and type 2 diabetes mellitus in humans...
  52. Tzung K Hsiai; Fiscal Year: 2015
    ..New Zealand White (NZW) rabbits on a hypercholesterolemic diet, and applied our intravascular methodology to the swine model...
  53. Ying Ge; Fiscal Year: 2015
    ..2) Determine altered protein modifications in KMRPs from hypertrophied and failing swine myocardium...
  54. Ellis L Reinherz; Fiscal Year: 2015
    ..Such alterations adversely impact public health preparedness. The current swine flu H1N1 pandemic 2009 strain is a case in point...
  55. Michel G Bergeron; Fiscal Year: 2014
    ..Seventeen viruses, including influenza A (such as avian flu and swine flu), influenza B, SARS coronavirus, parainfluenza, and adenovirus responsible for the majority of VRTI along with ..
  56. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..We are in the midst of an influenza pandemic caused by a novel H1N1 influenza strain that includes swine origin viral DNA...
  57. Lilach O Lerman; Fiscal Year: 2015
    ..To test this hypothesis we will utilize obese swine, a unique large animal model with a naturally occurring constellation of features of the MetS, and a combination ..
  58. Devendra K Agrawal; Fiscal Year: 2016
    ..effect of vitamin D status on the outcome measures of coronary patency following intervention in a well-controlled swine model of atherosclerosis and to determine the underlying cellular and molecular mechanisms...
  59. Debra Romberger; Fiscal Year: 2014
    ..vivo in a mouse model that has all of the prominent features of the pulmonary disorders seen in persons working in swine confinement facilities...
  60. Michael J Passineau; Fiscal Year: 2015
    ..Considering the substantial prior work that has been performed in miniature swine as a close-to- man model of salivary gland function, our first aim will be to upscale our UAGT technique in ..
  61. Chi Huey Wong; Fiscal Year: 2014
    ..g., the rapid emergence of Tamiflu resistant "swine flu" during the 2009 level-6 pandemic outbreak) and antigenic drift (i.e., escape from protective immunity)...
  62. Jianyi Zhang; Fiscal Year: 2015
    ..Comparing two swine models of LVH secondary to pressure overload or to postinfarction LV remodeling, the effects of MSCs ..
  63. LINDA HICKAM; Fiscal Year: 2014
    ..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and ..
  64. Devendra K Agrawal; Fiscal Year: 2016
    ..Aim 3: Our hypothesis predicts that enhanced inflammatory phenotype of EAT in obese and atherosclerotic swine is due to increased translocation of NF-?B to the nucleus via increased transcription and translation of importin-[..
  65. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..Furthermore, because we do not understand why certain viruses, such as the recent H1N1 2009 swine flu, are able to enter the human population and cause pandemics, we will also study the molecular basis of ..
  66. Lisa Murphy; Fiscal Year: 2016
    ..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to quickly screen ..
  67. Pre-emptive conditioning of the ischemic heart
    Dorothy E Vatner; Fiscal Year: 2012
    ..We will combine an in vitro system (isolated cardiac myocytes and gene knockdown) with mouse models in vivo (TG and KO) and a pre-clinical model (gene delivery in the swine) to address these goals comprehensively.
  68. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..We produced pigs (Sus scrofa) with a targeted disruption of both cystic fibrosis transmembrane conductance regulator (CFTR) alleles...
  69. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus.
  70. DOROTHY EILEEN VATNER; Fiscal Year: 2016
    ..Therefore, we developed a swine model of repetitive episodes of low-flow coronary stenosis, which reproduces the conditions of transient and ..
  71. SAMIR S MITRAGOTRI; Fiscal Year: 2016
    ..of In vivo Pharmacokinetic and Pharmacodynamic Efficacy, and Safety of Mucoadhesive Patches in Rats and Miniature Swine. Using Sprague Dawley rats as an animal model, we will assess the ability of patches to deliver therapeutic doses ..
  72. Development of novel and stable glucagon formulations for closed loop systems
    Roderike Pohl; Fiscal Year: 2013
    ..We will demonstrate biological activity in a swine model and we will demonstrate that our formulation is compatible with a marketed insulin pump system at elevated ..
  73. Glycan receptors specific for canine influenza infection
    Xiu Feng Wan; Fiscal Year: 2013
    ..As a zoonotic pathogen, influenza A viruses have a wide range of natural host reservoirs, such as avian, swine, equine, and sea mammals. All four known pandemic strains are of animal origin...
  74. DOUGLAS LAWRENCE MILLER; Fiscal Year: 2016
    ..Finally, a dosimetric algorithm for potential human DUS-PH will be developed and tested using a swine model of human DUS lung examination...
  75. Nam Van Hoang; Fiscal Year: 2016
    ..DAH organizations and public health agency (NIHE) to be able to develop and conduct a cross-section study of swine influenza at slaughterhouses in North, Central and South of Vietnam in one year (2), which provides baseline ..
  76. Development of a dual-function glucose sensing and hormone delivery catheter for
    W Kenneth Ward; Fiscal Year: 2013
    ..A miniaturized electronic module will be developed in order to test the device in anesthetized swine. In the swine, glucose sensing accuracy from sensing catheters through which insulin is delivered will be compared ..
  77. Geoffrey W Abbott; Fiscal Year: 2015
    ..physiology and in the etiology of AF, utilizing kcne2 (-/-) mice (which exhibit pacing-induced AF), rabbit and swine models of post-operative AF, confirmatory experiments with human atrial tissue, and in silico multiscale atrial ..
  78. Development of a wearable telemetry module and dual hormone infusion set for use
    Robert S Cargill; Fiscal Year: 2013
    ..We also propose to create an early prototype insertion device and carry out preliminary tests of the system in swine. In these tests, the three-part device with sensing catheter will be inserted subcutaneously into anesthetized ..
  79. Dipanwita Basu; Fiscal Year: 2015
    ..of influenza virus is very high, given that three such pandemics were recorded in the 20th century, plus the "swine" H1N1 pandemic of 2009...
  80. J Marc Simard; Fiscal Year: 2015
    ..as well as the evaluation of the device under continuous MRI for resection of an implanted "metastatic tumor" in swine brain...
  81. Stabilization Device for Transseptal Access
    MARK CHRISTIAN SVENDSEN; Fiscal Year: 2013
    ..MC relative to traditional means for TS access in human cadavers with heart failure and in chronic heart failure swine with MR...
  82. MELINA RAE KIBBE; Fiscal Year: 2016
    ..evaluate the safety and efficacy of the bioengineered ePTFE grafts in an atherosclerotic swine carotid artery ePTFE bypass model...
  83. Treatment of Cerebral Edema using Ventricular Therapy
    JIM STICE; Fiscal Year: 2013
    ..A controlled study of experimental TBI in swine was performed, which demonstrated elevation of CSF osmolality, reduction in intracranial pressure (ICP), ..
  84. Randall S Prather; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The overall goal of this application is to continue operation of the National Swine Resource and Research Center (NSRRC)...
  85. Coronary Post-Dilatation Catheter
    MARK CHRISTIAN SVENDSEN; Fiscal Year: 2013
    ..Preliminary results with the CB catheter system on the bench and in vivo in healthy swine showed excellent accuracy (1.4% diameter error), repeatability (1.1% diameter error), and safety...
  86. Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy
    Christene A Huang; Fiscal Year: 2013
    ..Similar to outcomes in humans, miniature swine develop severe GVHD, infectious complications, or hematopioetic failure following standard clinical myeloablative ..
  87. VENTILATION CONTROL TO REDUCE AIRBORNE CONTAMINANTS
    PATRICK O SHAUGHNESSY; Fiscal Year: 2001
    Studies have shown conclusively that airborne contaminant levels in swine confinements are typically of a sufficient level to pose a health hazard to workers in that occupation...
  88. Stephanie J Bryant; Fiscal Year: 2016
    ..model in personalized MACI using a large animal model, specifically to treat a chondral lesion in the knee of a swine (Aim 3)...
  89. Affinity Sensor-based Dual-Hormone Closed-Loop Glucose Control System
    Ralph Ballerstadt; Fiscal Year: 2013
    ..objective in the Phase I is to demonstrate feasibility and efficacy of the blood-glucose regulation in a diabetic swine model (anesthetized), using real-time data from the FAS device, and run by a well- described, and validated model-..
  90. INTESTINAL LIPOPROTEINS IN THE NEONATE
    Dennis Black; Fiscal Year: 2007
    Apolipoprotein A-IV expression is acutely up-regulated 7-fold by a high-fat diet in newborn swine, suggesting a role in lipid absorption...
  91. Contrast-Enhanced Ultrasound Detection of Secondary Lymph Nodes
    Barry B Goldberg; Fiscal Year: 2010
    ..Investigations using a melanoma swine model have demonstrated the superior accuracy of contrast-enhanced ultrasound (CEUS) compared to scintigraphy for ..
  92. Platform for MR-Guided Neurotherapeutic Drug Delivery
    EDWARD RAY BARKER; Fiscal Year: 2013
    ..We have successfully applied the platform to guide 30 convection enhanced delivery procedures in in-vivo swine brains and one gene delivery in a NHP model...
  93. REGULATION OF ENDOMETRIAL PROSTAGLANDIN F-2A SECRETION
    MARK MIRANDO; Fiscal Year: 1999
    ..The incidence of early embryonic mortality in swine is approximately 30-40% and is similar to that reported for women...
  94. Replication of Highly Pathogenic Avian Influenza Viruses in Swine
    Manoj Pastey; Fiscal Year: 2006
    ..Little is known about the permissiveness of swine to infection with HPAI H5N1 viruses...
  95. Nipah Virus Marker Vaccine and Companion Diagnostic Test
    James Roth; Fiscal Year: 2005
    Nipah virus infection is an emerging new disease of humans and swine, first described during a 1998-1999 epidemic in Malaysia...
  96. Large Animal Model of Spinal Muscular Atrophy
    MONIQUE LORSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project summary/abstract: This application proposes the generation of a swine model of Spinal Muscular Atrophy (SMA) (pSMN1-/-;hSMN2) using somatic cell nuclear transfer of gene targeted fetal ..
  97. PATHOGENESIS OF THE HEPATITIS E VIRUS: A SWINE MODEL
    Xiang Jin Meng; Fiscal Year: 2000
    ..S). HEV strains recovered from patients in the U.S. are remarkably similar genetically to the swine hepatitis E virus (swine HEV) isolated from pigs in the U.S...
  98. Molecular Determinants of Virulence Porcine Circovirus 2
    Steven Krakowka; Fiscal Year: 2004
    ..the pathogenicity of the plant and avian circoviruses is well known, only recently have the disease potential of swine circoviruses been realized...
  99. Host range restriction of human influenza viruses
    Christopher Olsen; Fiscal Year: 2009
    ..within the context of pandemic influenza virus development, the nature of human influenza virus infection of swine cells and pigs...
  100. Wavebreak at the Onset of Ventricular Fibrillation
    Jack Rogers; Fiscal Year: 2009
    ..The phenomenon will be studied in normal swine hearts, in swine hearts with healed infarcts and pacing-induced cardiomyopathy, and in myopathic human hearts...
  101. Pathogenesis of Infectious in Swine with Pathogenic Avian Influenza Viruses
    BH JANKE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The objective of this project is to define the permissiveness of swine to infection with highly pathogenic avian influenza viruses and to define the specific sites, adaptability, and ..

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