Drosophila simulans

Summary

Alias:

Top Publications

  1. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
  2. pmc A rapidly evolving MYB-related protein causes species isolation in Drosophila
    Daniel A Barbash
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Proc Natl Acad Sci U S A 100:5302-7. 2003
  3. pmc Intraspecific and interspecific variation at the y-ac-sc region of Drosophila simulans and Drosophila melanogaster
    J M Martin-Campos
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 130:805-16. 1992
  4. pmc The genetics of reproductive isolation in the Drosophila simulans clade: X vs. autosomal effects and male vs. female effects
    H Hollocher
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 143:1243-55. 1996
  5. pmc Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture
    M T Hamblin
    Laboratoire d Ecologie EPHE, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Genetics 153:305-17. 1999
  6. pmc Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar
    Yi Guo
    Rosenstiel Biomedical Research Center, Brandeis University, Waltham, MA 02454, USA
    Mol Biol Cell 16:1406-16. 2005
  7. pmc Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation
    Colin D Meiklejohn
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 168:265-79. 2004
  8. pmc The population genetics of the origin and divergence of the Drosophila simulans complex species
    R M Kliman
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Genetics 156:1913-31. 2000
  9. ncbi Nucleotide variation at the runt locus in Drosophila melanogaster and Drosophila simulans
    J A Labate
    Department of Ecology and Evolution, State University of New York at Stony Brook, USA
    Mol Biol Evol 16:724-31. 1999
  10. pmc Signature of selective sweep associated with the evolution of sex-ratio drive in Drosophila simulans
    Nicolas Derome
    Ecole Pratique des Hautes Etudes, Laboratoire d Ecologie, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Genetics 166:1357-66. 2004

Research Grants

  1. Molecular basis of reproductive isolation in Drosophila
    AMANDA MOEHRING; Fiscal Year: 2007
  2. Daniel A Barbash; Fiscal Year: 2016
  3. Daven C Presgraves; Fiscal Year: 2015
  4. Clade-specific changes in transcription of olfactory genes in fruit flies
    EREZYILMAZ DENIZ; Fiscal Year: 2009
  5. Empirical analysis of natural selection on codon usage in eukaryotes
    RICHARD KLIMAN; Fiscal Year: 2007
  6. POPULATION GENETICS OF D SIMULANS AND D MELANOGASTER
    DAVID BEGUN; Fiscal Year: 2001
  7. Genetic Basis of Posterior Lobe Evolution in Drosophila
    Barry Williams; Fiscal Year: 2005
  8. The evolution of gene expression in Drosophila
    COLIN MEIKLEJOHN; Fiscal Year: 2007
  9. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
  10. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2008

Patents

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  2. Method of identifying eukaryotic species
  3. SNORNA, COMPOSITIONS AND USES
  4. Process for the production of lutein
  5. Plants with increased yield (nue)
  6. Process for the control of production of fine chemicals
  7. Proteins associated with abiotic stress response and homologs
  8. Method of preparating merkmal for distinguishing insect
  9. Proteins associated with abiotic stress response and homologs
  10. Method of identifying eukaryotic species

Detail Information

Publications200 found, 100 shown here

  1. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
    ..We suggest that these excess replacement substitutions result from adaptive fixation of selectively advantageous mutations...
  2. pmc A rapidly evolving MYB-related protein causes species isolation in Drosophila
    Daniel A Barbash
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Proc Natl Acad Sci U S A 100:5302-7. 2003
    ..Our results suggest that hybrid lethality may result from disruptions in gene regulation, and we also propose that rapid evolution may be a hallmark of speciation genes in general...
  3. pmc Intraspecific and interspecific variation at the y-ac-sc region of Drosophila simulans and Drosophila melanogaster
    J M Martin-Campos
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 130:805-16. 1992
    A 2.2-kb region including the ac gene of Drosophila simulans has been sequenced. Interspecific divergence between Drosophila melanogaster and D. simulans was estimated as 0.0695 and 0.0558 for silent and for all sites, respectively...
  4. pmc The genetics of reproductive isolation in the Drosophila simulans clade: X vs. autosomal effects and male vs. female effects
    H Hollocher
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 143:1243-55. 1996
    ..of homozygous autosomal regions on reproductive isolation was found for crosses between the species in the Drosophila simulans clade. Second chromosome regions were introgressed from D. mauritiana and D. sechellia into D...
  5. pmc Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture
    M T Hamblin
    Laboratoire d Ecologie EPHE, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Genetics 153:305-17. 1999
    Previous studies based on allozyme variation have found little evidence for genetic differentiation in Drosophila simulans. On the basis of DNA sequence variation at two nuclear loci in four African populations of D...
  6. pmc Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar
    Yi Guo
    Rosenstiel Biomedical Research Center, Brandeis University, Waltham, MA 02454, USA
    Mol Biol Cell 16:1406-16. 2005
    ..Such isoform variation may be a general strategy for adapting a common regulatory mechanism to specifically control motion and positioning of multiple organelles...
  7. pmc Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation
    Colin D Meiklejohn
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 168:265-79. 2004
    ..intraspecific variation in three tandemly arranged, testes-expressed genes (janusA, janusB, and ocnus) in Drosophila simulans included all three of these features...
  8. pmc The population genetics of the origin and divergence of the Drosophila simulans complex species
    R M Kliman
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Genetics 156:1913-31. 2000
    The origins and divergence of Drosophila simulans and close relatives D. mauritiana and D. sechellia were examined using the patterns of DNA sequence variation found within and between species at 14 different genes. D...
  9. ncbi Nucleotide variation at the runt locus in Drosophila melanogaster and Drosophila simulans
    J A Labate
    Department of Ecology and Evolution, State University of New York at Stony Brook, USA
    Mol Biol Evol 16:724-31. 1999
    ..simulans lines. This indicated an old lineage and may reflect ancestral population substructuring in D. simulans...
  10. pmc Signature of selective sweep associated with the evolution of sex-ratio drive in Drosophila simulans
    Nicolas Derome
    Ecole Pratique des Hautes Etudes, Laboratoire d Ecologie, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Genetics 166:1357-66. 2004
    ..and a distorting X chromosome originating from the Seychelles to map a candidate sex-ratio region in Drosophila simulans using molecular biallelic markers...
  11. pmc Adaptive evolution of Cid, a centromere-specific histone in Drosophila
    H S Malik
    Howard Hughes Medical Institute, Seattle, Washington 98109, USA
    Genetics 157:1293-8. 2001
    ..Thus, centromeric H3-like proteins may act as adaptors between evolutionarily labile centromeric DNA and the conserved kinetochore machinery...
  12. ncbi Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit
    Gaelle Le Goff
    UMR 1112, INRA Université de Nice Sophia Antipolis, Sophia Antipolis, France
    J Neurochem 92:1295-305. 2005
    The Eyguieres 42 strain of Drosophila simulans, obtained by laboratory selection, displayed approximately 20,000-fold resistance to the insecticide fipronil...
  13. doi Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila
    Arièle Legendre
    Université ParisXI, UMR8620, CNRS, 91405 Orsay Cedex, France
    Insect Biochem Mol Biol 38:244-55. 2008
    ..species exhibit polymorphism in female pheromonal cuticular hydrocarbons, with 7-monoenes produced in Drosophila simulans and 7,11-dienes in most populations of Drosophila melanogaster (5,9-dienes in several African populations)...
  14. ncbi Drosophila simulans Lethal hybrid rescue mutation (Lhr) rescues inviable hybrids by restoring X chromosomal dosage compensation and causes fluctuating asymmetry of development
    R N Chatterjee
    Department of Zoology, University of Calcutta, 35 B C Road, Kolkata, India
    J Genet 86:203-15. 2007
    The Drosophila simulans Lhr rescues lethal hybrids from the cross of D. melanogaster and D. simulans...
  15. doi A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and quaternary structure modeling of Drosophila simulans cytochrome c oxidase
    Richard G Melvin
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052, NSW, Australia
    J Mol Evol 66:232-42. 2008
    ..approach to study sequence variation in cytochrome c oxidase (COX) genes within and among three distinct Drosophila simulans mtDNA haplogroups...
  16. pmc Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans
    Todd A Schlenke
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 169:2013-22. 2005
    Immune system genes in a California population sample of Drosophila simulans were shown to bear several hallmarks of the effects of past directional selection...
  17. pmc The rosy region of Drosophila melanogaster and Drosophila simulans. I. Contrasting levels of naturally occurring DNA restriction map variation and divergence
    C F Aquadro
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853
    Genetics 119:875-88. 1988
    ..loci was analyzed for restriction map variation among 60 lines of Drosophila melanogaster and 30 lines of Drosophila simulans collected together at a single locality in Raleigh, North Carolina. DNA sequence variation in D...
  18. pmc Genetics of reproductive isolation in the Drosophila simulans clade: DNA marker-assisted mapping and characterization of a hybrid-male sterility gene, Odysseus (Ods)
    D E Perez
    Department of Ecology and Evolution, University of Chicago, Illinois 60637
    Genetics 134:261-75. 1993
    ..to introgress small segments of the X chromosome from Drosophila mauritiana (or Drosophila sechellia) into Drosophila simulans by repeated backcrosses for more than 20 generations...
  19. pmc Genetics of reproductive isolation in the Drosophila simulans clade: complex epistasis underlying hybrid male sterility
    E L Cabot
    Department of Ecology and Evolution, University of Chicago, Illinois 60637
    Genetics 137:175-89. 1994
    ..one-fourth of the X chromosome from either Drosophila mauritiana or Drosophila sechellia into the genome of Drosophila simulans using a series of visible and DNA markers...
  20. pmc Offsetting effects of Wolbachia infection and heat shock on sperm production in Drosophila simulans: analyses of fecundity, fertility and accessory gland proteins
    R R Snook
    Department of Organismal Biology and Anatomy, The University of Chicago, Illinois 60637, USA
    Genetics 155:167-78. 2000
    Infection in Drosophila simulans with the endocellular symbiont Wolbachia pipientis results in egg lethality caused by failure to properly initiate diploid development (cytoplasmic incompatibility, CI)...
  21. ncbi Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 314:1292-5. 2006
    ..Here, we show that Lethal hybrid rescue (Lhr) has functionally diverged in Drosophila simulans and interacts with Hybrid male rescue (Hmr), which has functionally diverged in D...
  22. pmc Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans
    J Parsch
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 01238 2020, USA
    Genetics 159:647-57. 2001
    Levels of nucleotide polymorphism in three paralogous Drosophila simulans genes, janusA (janA), janusB (janB), and ocnus (ocn), were surveyed by DNA sequencing. The three genes lie in tandem within a 2.5-kb region of chromosome arm 3R...
  23. ncbi Cytonuclear coadaptation in Drosophila: disruption of cytochrome c oxidase activity in backcross genotypes
    Timothy B Sackton
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Evolution 57:2315-25. 2003
    ..New sequence data for nuclear encoded subunits of COX identified amino acids that may play a role in the disruption effect...
  24. pmc Evidence for adaptive evolution of the G6pd gene in the Drosophila melanogaster and Drosophila simulans lineages
    W F Eanes
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794
    Proc Natl Acad Sci U S A 90:7475-9. 1993
    ..32 and 12 copies of the glucose-6-phosphate dehydrogenase (G6pd) gene in Drosophila melanogaster and Drosophila simulans, respectively. Both species exhibit similar levels of nucleotide polymorphism at synonymous sites. D...
  25. pmc Estimating ancestral population parameters
    J Wakeley
    Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855 1059, USA
    Genetics 145:847-55. 1997
    ..Computer simulations show that current and historical population parameters can be estimated accurately. The methods are applied to DNA data from two species of Drosophila and to some human mitochondrial DNA sequences...
  26. ncbi Natural selection drives extremely rapid evolution in antiviral RNAi genes
    Darren J Obbard
    Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Curr Biol 16:580-5. 2006
    ..This is a signature of host-pathogen arms races and implies that the ancient battle between RNA viruses and host antiviral RNAi genes is active and significant in shaping RNAi function...
  27. pmc Genomic effects of nucleotide substitutions in Drosophila simulans
    Andrew D Kern
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 162:1753-61. 2002
    ..Here we present a permutation-based analysis of nucleotide polymorphisms and fixations in Drosophila simulans. We show evidence of pervasive small-scale hitchhiking effects in this lineage...
  28. pmc Contrasted polymorphism patterns in a large sample of populations from the evolutionary genetics model Drosophila simulans
    Emmanuelle Baudry
    Ecole Pratique des Hautes Etudes, Universite Pierre et Marie Curie, Paris, France
    Genetics 173:759-67. 2006
    African populations of Drosophila simulans are thought to be ancestral in this model species and are increasingly used for testing general hypotheses in evolutionary genetics...
  29. pmc Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone
    Harmit S Malik
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 99:1449-54. 2002
    ..the adaptive evolution of the Drosophila CenH3 (Cid) in comparisons of Drosophila melanogaster and Drosophila simulans, a divergence of approximately 2.5 million years...
  30. pmc Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. I. Differential accumulation of hybrid male sterility effects on the X and autosomes
    Yun Tao
    DCMB and Department of Zoology, Duke University, Durham, NC 27708, USA
    Genetics 164:1383-97. 2003
    ..Possible mechanisms of a "large X" effect include selective fixation of new mutations that are recessive or partially recessive and the evolution of sex-ratio distortion systems...
  31. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  32. pmc Testing models of selection and demography in Drosophila simulans
    Jeffrey D Wall
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 162:203-16. 2002
    ..of nucleotide variability at 15 X-linked loci and 14 autosomal loci from a North American population of Drosophila simulans. We show that there is significantly more linkage disequilibrium on the X chromosome than on chromosome arm ..
  33. pmc Reduced variation in Drosophila simulans mitochondrial DNA
    J W Ballard
    Department of Zoology, Field Museum, Chicago, Illinois 60605 2496, USA
    Genetics 144:1519-28. 1996
    We investigated the evolutionary dynamics of infection of a Drosophila simulans population by a maternally inherited insect bacterial parasite, Wolbachia, by analyzing nucleotide variability in three regions of the mitochondrial genome ..
  34. pmc Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism
    K J Schmid
    Zoologisches Institut, Universitat Munchen, 80333 München, Germany
    Genetics 153:1717-29. 1999
    ....
  35. pmc Hybrid lethal systems in the Drosophila melanogaster species complex. I. The maternal hybrid rescue (mhr) gene of Drosophila simulans
    K Sawamura
    Department of Genetics, Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka, Japan
    Genetics 133:299-305. 1993
    Hybrid females from Drosophila simulans females x Drosophila melanogaster males die as embryos while hybrid males from the reciprocal cross die as late larvae. The other two classes are sterile adults...
  36. pmc Genetics of a difference in male cuticular hydrocarbons between two sibling species, Drosophila simulans and D. sechellia
    J A Coyne
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 143:1689-98. 1996
    ....
  37. ncbi Divergence of mitochondrial dna is not corroborated by nuclear dna, morphology, or behavior in Drosophila simulans
    J William O Ballard
    Department of Biological Sciences, University of Iowa, Iowa City 52242, USA
    Evolution 56:527-45. 2002
    We ask whether the observed mitochondrial DNA (mtDNA) population subdivision of Drosophila simulans is indicative of organismal structure or of specific processes acting on the mitochondrial genome...
  38. pmc Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome
    Yun Tao
    DCMB and Department of Zoology, Duke University, Durham, NC 27708, USA
    Genetics 164:1399-418. 2003
    ..These results are consistent with the gradual evolution of hybrid incompatibilities as a by-product of genetic divergence in allopatric populations...
  39. ncbi Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. III. Heterogeneous accumulation of hybrid incompatibilities, degree of dominance, and implications for Haldane's rule
    Yun Tao
    Developmental, Cell and Molecular Biology Group, Department of Zoology, Duke University, Durham, North Carolina 27708, USA
    Evolution 57:2580-98. 2003
    ..of Haldane's rule was investigated through estimating the accumulation of hybrid incompatibilities between Drosophila simulans and D. mauritiana by means of introgression...
  40. pmc Genetic analysis of a morphological shape difference in the male genitalia of Drosophila simulans and D. mauritiana
    J Liu
    Department of Zoology, Duke University, Durham, North Carolina 27708, USA
    Genetics 142:1129-45. 1996
    ..Although there is some evidence of partial dominance of mauritiana alleles and for epistasis, the pattern of inheritance is largely additive...
  41. ncbi Variability on the dot chromosome in the Drosophila simulans clade
    Mohamed A F Noor
    Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 118:51-8. 2003
    A recent study suggested that recent nuclear gene introgression between Drosophila simulans and D. mauritiana may have obscured efforts to estimate the phylogeny of the species of the D...
  42. pmc Nucleotide variation and recombination along the fourth chromosome in Drosophila simulans
    Wen Wang
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 166:1783-94. 2004
    ..melanogaster. Finally, estimates of the recombination parameters are shown to support a crossover-plus-conversion model...
  43. pmc DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure
    J Rozas
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona, Spain
    Genetics 158:1147-55. 2001
    ..3-kb region including the rp49 gene plus its 5' and 3' flanking regions was sequenced in 24 lines of Drosophila simulans (10 from Spain and 14 from Mozambique). Fifty-four nucleotide and 8 length polymorphisms were detected...
  44. pmc Unusual pattern of nucleotide sequence variation at the OS-E and OS-F genomic regions of Drosophila simulans
    Alejandro Sanchez-Gracia
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
    Genetics 175:1923-35. 2007
    ..encompassing the odorant-binding protein genes OS-E and OS-F (OS region) was surveyed in two populations of Drosophila simulans, one from Europe and the other from Africa...
  45. pmc Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 167:1265-74. 2004
    ..quantitative trait loci (QTL) contributing to prezygotic reproductive isolation between the sibling species Drosophila simulans and D. mauritiana. We mapped at least seven QTL affecting discrimination of D. mauritiana females against D...
  46. pmc Genetic control of pheromones in Drosophila simulans. II. kété, a locus on the X chromosome
    J F Ferveur
    Laboratoire de Biologie et Génétique Evolutives, CNRS, Gif sur Yvette, France
    Genetics 133:561-7. 1993
    ..To investigate X-linked loci, EMS mutations were induced in Drosophila simulans flies...
  47. ncbi A mariner-like element with a 5' lesion in Drosophila simulans
    Keiji Ogura
    Drosophila Genetic Resource Center, Kyoto Institute of Technology, Saga Ippongi cho, Ukyo ku, Kyoto 616 8354, Japan
    Genetica 119:229-35. 2003
    The unstable white-S2 (wS2) allele of the white gene occurred spontaneously in the S2 strain of Drosophila simulans. This mutation was caused by insertion of the submariner element, a mariner-like element with an abnormal tandem ..
  48. ncbi Phylogenetic test of the molecular clock and linearized trees
    N Takezaki
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA
    Mol Biol Evol 12:823-33. 1995
    ..A linearized tree will then be constructed for a given topology for the remaining sequences under the assumption of rate constancy. We have used these methods to analyze hominoid mitochondrial DNA and drosophilid Adh gene sequences...
  49. ncbi Comparative genomics of mitochondrial DNA in Drosophila simulans
    J W Ballard
    The Field Museum, 1400 S Lake Shore Drive, Chicago, IL 60605 2496, USA
    J Mol Evol 51:64-75. 2000
    ..study compares the nucleotide variation among 22 complete mitochondrial genomes of the three distinct Drosophila simulans haplotypes with intron 1 of the alcohol dehydrogenase-related locus...
  50. pmc A fine-scale genetic analysis of hybrid incompatibilities in Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Genetics 163:955-72. 2003
    ..Finally, I estimate that a total of approximately 191 hybrid-lethal incompatibilities separate D. melanogaster and D. simulans, indicating extensive functional divergence between these species' genomes...
  51. pmc Reduced fertility of Drosophila melanogaster hybrid male rescue (Hmr) mutant females is partially complemented by Hmr orthologs from sibling species
    S Aruna
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 181:1437-50. 2009
    ..We show that In(1)AB is mutant for Hmr function, likely due to a missense mutation in an evolutionarily conserved amino acid. Two independently discovered hybrid rescue mutations are therefore allelic...
  52. pmc Molecular evolution of odorant-binding protein genes OS-E and OS-F in Drosophila
    D S Hekmat-Scafe
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Genetics 155:117-27. 2000
    ..Finally, a phylogenetic analysis places both OS-E and OS-F within a large family of insect OBPs and OBP-like proteins...
  53. pmc Cis-by-Trans regulatory divergence causes the asymmetric lethal effects of an ancestral hybrid incompatibility gene
    Shamoni Maheshwari
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 8:e1002597. 2012
    ..We present a model whereby hybrid lethality occurs by the interaction between evolutionarily ancestral and derived alleles...
  54. pmc Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans
    Jose M Ranz
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genome Res 14:373-9. 2004
    When females of Drosophila melanogaster and males of Drosophila simulans are mated, the male progeny are inviable, whereas the female progeny display manifold malformations and are sterile...
  55. pmc The developmental genetics of hybrid inviability: a mitotic defect in Drosophila hybrids
    H A Orr
    Department of Biology, University of Rochester, NY 14627, USA
    Genetics 145:1031-40. 1997
    ..melanogaster and autosomal gene(s) from D. melanogaster's sister species...
  56. pmc Centromere targeting element within the histone fold domain of Cid
    Danielle Vermaak
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:7553-61. 2002
    ..We suggest that the process of deposition of (Cid.H4)2 tetramers allows for discriminating contacts to be made between loop I and DNA, providing the specificity needed for targeting...
  57. pmc Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility
    Kyoichi Sawamura
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Genetics 186:669-76. 2010
    ..analyzing genes for reproductive isolation by replacing Drosophila melanogaster genes with homologs from Drosophila simulans by interspecific backcrossing...
  58. pmc Evidence for recurrent paralogous gene conversion and exceptional allelic divergence in the Attacin genes of Drosophila melanogaster
    B P Lazzaro
    Institute of Molecular Evolutionary Genetics, Department of Biology, Penn State University, University Park, Pennsylvania 16802, USA
    Genetics 159:659-71. 2001
    ..All three genes are characterized by divergent haplotypes, and one Attacin AB allele appears to have recently increased rapidly in frequency in the population...
  59. pmc A high-frequency null mutant of an odorant-binding protein gene, Obp57e, in Drosophila melanogaster
    Aya Takahashi
    Division of Population Genetics, National Institute of Genetics, Mishima, Japan
    Genetics 170:709-18. 2005
    ..In addition, the Obp57d gene region showed an excess of high-frequency-derived mutants that is consistent with a pattern predicted under positive natural selection...
  60. doi The acylphosphatase (Acyp) alleles associate with male hybrid sterility in Drosophila
    Pawel Michalak
    Department of Biology, University of Texas Arlington, Arlington, Texas 76019, USA
    Gene 416:61-5. 2008
    ..biological membranes, is involved in genetic incompatibilities leading to male sterility in hybrids between Drosophila simulans and D. mauritiana...
  61. ncbi Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans
    Nicolas Derome
    Ecole Pratique des Hautes Etudes, Paris, France
    Mol Biol Evol 25:409-16. 2008
    ..We surveyed DNA sequence variation in a region formerly identified as causing "sex-ratio" meiotic drive in Drosophila simulans. We found evidence that this system evolved by positive selection at 2 neighboring loci, which thus appear ..
  62. ncbi Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites
    Laura Fanti
    Dipartimento di Genetica e Biologia Molecolare, Istituto Pasteur, Fondazione Cenci Bolognetti, Universita La Sapienza, 00185 Roma, Italy
    Genetica 117:135-47. 2003
    ..In addition to its role in heterochromatin assembly and telomere stability, we propose that HP1 plays an important role in regulating the expression of many different euchromatic regions...
  63. pmc Rapid evolution of two odorant-binding protein genes, Obp57d and Obp57e, in the Drosophila melanogaster species group
    Takashi Matsuo
    Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192 0397, Japan
    Genetics 178:1061-72. 2008
    ..Our analyses demonstrate that these two classes of differences can be distinguished by comparisons of many genomic sequences from closely related species...
  64. pmc Genetic analysis of the hybrid male rescue locus of Drosophila
    H A Orr
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Genetics 155:225-31. 2000
    ..These findings support previous claims that hybrid embryonic and larval lethalities are genetically distinct and suggest that Hmr(mel) is at least one of the proximate causes of hybrid larval inviability...
  65. ncbi Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila
    M Bodmer
    Nature 309:425-30. 1984
    ..A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromosome banding patterns...
  66. doi A new test for selection applied to codon usage in Drosophila simulans and D. mauritiana
    Ana Llopart
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    J Mol Evol 66:224-31. 2008
    ..We also applied this novel test to 14 newly sequenced loci in five strains of D. mauritiana, showing for the first time ongoing selection on codon usage in this species...
  67. doi Inter-island divergence within Drosophila mauritiana, a species of the D. simulans complex: Past history and/or speciation in progress?
    D Legrand
    Laboratoire Evolution, Genomes et Speciation, UPR 9034, CNRS, 91198 Gif sur Yvette Cedex, France
    Mol Ecol 20:2787-804. 2011
    ..Species of the Drosophila simulans complex provide a good model for speciation and evolutionary studies, and hence understanding their ..
  68. pmc Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities
    Shanwu Tang
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 323:779-82. 2009
    ..We show that the nucleoporin 160kDa (Nup160) gene of the fruitfly Drosophila simulans is incompatible with one or more factors on the D. melanogaster X chromosome, causing hybrid lethality...
  69. pmc Large-scale adaptive hitchhiking upon high recombination in Drosophila simulans
    Humberto Quesada
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Genetics 165:895-900. 2003
    ..variation across a highly recombining approximately 88-kb genomic fragment in an African population of Drosophila simulans. We find a core region of up to 38 kb with a major haplotype at intermediate frequency...
  70. pmc Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila
    J S Platero
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Cell Biol 140:1297-306. 1998
    ..Upon decondensation, GAGA factor and Prod shift from low affinity sites within satellite DNA back to euchromatic sites as a self-assembly process...
  71. ncbi DNA sequence variation at a duplicated gene: excess of replacement polymorphism and extensive haplotype structure in the Drosophila melanogaster bicoid region
    John F Baines
    Department Biologie II Evolutionsbiologie, Universitat Munchen, Germany
    Mol Biol Evol 19:989-98. 2002
    ....
  72. pmc Strong selective sweep associated with a transposon insertion in Drosophila simulans
    Todd A Schlenke
    Section of Evolution and Ecology, Division of Biological Sciences, University of California Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:1626-31. 2004
    ..Here, we present population genetic data from several loci across chromosome arm 2R in Drosophila simulans. A 100-kb segment from a freely recombining region of this chromosome shows extremely reduced ..
  73. ncbi Location of X-linked polygenic effects causing sterility in male hybrids of Drosophila simulans and D. mauritiana
    H F Naveira
    Departamento de Biologia Fundamental, Unidad de Genetica, Facultad de Biologia, Universidad de Santiago, Spain
    Heredity (Edinb) 68:211-7. 1992
    ..simulans/D. mauritiana hybrids, located by recombination on the X chromosome, are indeed 'effective factors', or located polygenic effects. Some of the consequences of this finding are explored...
  74. doi An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup and phylogenetic analysis
    Lei Lei Zhan
    College of Life Science, Hubei University, Wuhan 430062, People s Republic of China
    J Hered 99:417-20. 2008
    ..Previous study revealed that Drosophila melanogaster and Drosophila simulans had lost an intron precisely within the tyrosine kinase (TyK) domain of this gene...
  75. ncbi Comparative genomic analysis of allatostatin-encoding (Ast) genes in Drosophila species and prediction of regulatory elements by phylogenetic footprinting
    P R F Bowser
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ont M5S 3G5, Canada
    Peptides 28:83-93. 2007
    ..We performed comparative analyses of Ast genes from seven Drosophila species (Drosophila melanogaster, Drosophila simulans, Drosophila ananassae, Drosophila yakuba, Drosophila pseudoobscura, Drosophila mojavensis, and Drosophila ..
  76. pmc Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassae
    W Stephan
    Department of Zoology, University of Maryland, College Park 20742
    Genetics 138:135-43. 1994
    ..3, Mtn1, and Dp(Mtn1), where the latter designates a tandem duplication of Mtn1. In Drosophila simulans, only Mtn.3-type alleles have been found. It has been suggested that Mtn...
  77. ncbi Testing the neutral theory of molecular evolution with genomic data from Drosophila
    Justin C Fay
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nature 415:1024-6. 2002
    ..A comparison of the A/S ratio of polymorphism in Drosophila melanogaster with that of divergence from Drosophila simulans shows that the A/S ratio of divergence is twice as high---a difference that is often attributed to positive ..
  78. pmc Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr
    Shamoni Maheshwari
    Department of Molecular Biology and Genetics, Cornell University, USA
    Mol Biol Evol 25:2421-30. 2008
    Lethality in hybrids between Drosophila melanogaster and its sibling species Drosophila simulans is caused in part by the interaction of the genes Hybrid male rescue (Hmr) and Lethal hybrid rescue (Lhr)...
  79. pmc The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements
    Claudia S Copeland
    Department of Tropical Medicine, Tulane University Health Sciences Center, New Orleans, USA
    BMC Evol Biol 5:20. 2005
    ..It is becoming apparent that numerous LTR retrotransposons and other mobile genetic elements have colonized the genome of the human blood fluke, Schistosoma mansoni...
  80. pmc Evolution of gene expression in the Drosophila olfactory system
    Artyom Kopp
    Section of Evolution and Ecology, University of California, Davis, USA
    Mol Biol Evol 25:1081-92. 2008
    ..a narrow ecological specialist that feeds on the fruit of Morinda citrifolia, with its close relatives Drosophila simulans and Drosophila melanogaster, which feed on a wide variety of decaying plant matter...
  81. ncbi Superinfection of Laodelphax striatellus with Wolbachia from Drosophila simulans
    L Kang
    Institute of Genetics, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China
    Heredity (Edinb) 90:71-6. 2003
    ..In this study, we used both microinjection and nested PCR to show that the Wolbachia naturally infecting Drosophila simulans can be transferred into a naturally Wolbachia-infected strain of the small brown planthopper Laodelphax ..
  82. ncbi Transepithelial transport of salicylate by the Malpighian tubules of insects from different orders
    Esau Ruiz-Sanchez
    Department of Biology, McMaster University, Hamilton, Ont, Canada
    J Insect Physiol 53:1034-45. 2007
    ..The transepithelial transport of salicylate by the Malpighian tubules of Drosophila simulans, Drosophila erecta, Drosophila sechellia, and Acheta domesticus was saturable, Na(+)-dependent and ..
  83. pmc Characterization of Wolbachia host cell range via the in vitro establishment of infections
    Stephen L Dobson
    Section of Vector Biology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06437, USA
    Appl Environ Microbiol 68:656-60. 2002
    ..albopictus (Diptera: Culicidae) cell line can support five different Wolbachia infection types derived from Drosophila simulans (Diptera: Drosophilidae), Culex pipiens (Culicidae), and Cadra cautella (Lepidoptera: Phycitidae)...
  84. pmc Lack of correlation between interspecific divergence and intraspecific polymorphism at the suppressor of forked region in Drosophila melanogaster and Drosophila simulans
    C H Langley
    Center for Population Biology, University of California, Davis 95616
    Proc Natl Acad Sci U S A 90:1800-3. 1993
    ..at the suppressor of forked [su(f)] region in natural populations of Drosophila melanogaster and Drosophila simulans are estimated by restriction map analysis...
  85. pmc Wolbachia interferes with ferritin expression and iron metabolism in insects
    Natacha Kremer
    Universite de Lyon, Lyon, France
    PLoS Pathog 5:e1000630. 2009
    ..tabida, but also in facultative parasitism involving Drosophila simulans and in Aedes aegypti cells...
  86. ncbi Cloning and characterization of a gene encoding glutathione-regulated potassium-efflux system protein KefKL from the endosymbiont Wolbachia
    Lin Kang
    Institute of Genetics, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, People s Republic of China
    DNA Seq 13:375-81. 2002
    ..A gene encoding glutathione-regulated potassium-efflux system protein KefKL from Wolbachia in Drosophila simulans Riverside (w Ri) was isolated...
  87. pmc Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila
    Patrick M Ferree
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Biol 7:e1000234. 2009
    ..discovered Drosophila melanogaster locus called Zhr causes lethality in F1 daughters from crosses between Drosophila simulans females and D. melanogaster males. Zhr maps to a heterochromatic region of the D...
  88. doi Divergence times in Caenorhabditis and Drosophila inferred from direct estimates of the neutral mutation rate
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Canada
    Mol Biol Evol 25:778-86. 2008
    ..Dates inferred for the common ancestor of Drosophila melanogaster and Drosophila simulans are roughly concordant with previous studies...
  89. pmc Evolutionary dynamics of wAu-like Wolbachia variants in neotropical Drosophila spp
    Wolfgang J Miller
    Laboratories of Genome Dynamics, Center of Anatomy and Cell Biology, Medical University of Vienna, Währingerstr 10, A 1090 Vienna, Austria
    Appl Environ Microbiol 72:826-35. 2006
    ..Most research focuses on two Old Word hosts, Drosophila melanogaster and Drosophila simulans, and does not take into account that some of the Wolbachia associations in these species may have evolved ..
  90. pmc Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds
    David M Rand
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 172:329-41. 2006
    ..bp substitutions between mtDNAs), and introgression strains of Drosophila melanogaster carrying mtDNA from Drosophila simulans in a D...
  91. pmc Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction
    Grant L Hughes
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Pathog 7:e1001296. 2011
    ..cells can be stably infected with multiple Wolbachia strains such as wAlbB from Aedes albopictus, wRi from Drosophila simulans and wMelPop from Drosophila melanogaster...
  92. pmc Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genome Biol 6:R67. 2005
    ..No consistent patterns have emerged from studies that have investigated general levels of evolutionary constraint in introns...
  93. ncbi Rapid evolution and gene-specific patterns of selection for three genes of spermatogenesis in Drosophila
    Alberto Civetta
    Department of Biology, University of Winnipeg, Winnipeg, Manitoba, Canada
    Mol Biol Evol 23:655-62. 2006
    ..The complete coding region of these genes was sequenced in different strains of Drosophila melanogaster and Drosophila simulans. All three genes showed rapid divergence between species, with larger numbers of nonsynonymous to ..
  94. pmc Phylogenetic incongruence in the Drosophila melanogaster species group
    Alex Wong
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Mol Phylogenet Evol 43:1138-50. 2007
    ..We focus on two nodes: (1) the node joining the Drosophila erecta-Drosophila orena, Drosophila melanogaster-Drosophila simulans, and Drosophila yakuba-Drosophila teissieri lineages, and (2) the node joining the lineages leading to the ..
  95. ncbi Characterization of non-cytoplasmic incompatibility inducing Wolbachia in two continental African populations of Drosophila simulans
    S Charlat
    Laboratoire Dymanique du Génome et Evolution, Institut Jacques Monod, CNRS Université Paris 6 and 7, France
    Heredity (Edinb) 90:49-55. 2003
    ..This phenomenon is observed in Drosophila simulans, an intensively studied Wolbachia host, harbouring at least five distinct bacterial strains...
  96. ncbi The genetics of mating recognition between Drosophila simulans and D. sechellia
    Alberto Civetta
    Department of Biology, University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9
    Genet Res 82:117-26. 2003
    ..the genetic basis of interspecific differences in male mating behaviour and pheromone concentration between Drosophila simulans and D. sechellia by using Drosophila simulans/D. sechellia introgression lines...
  97. ncbi Effects of Wolbachia on sperm maturation and architecture in Drosophila simulans Riverside
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mech Dev 124:699-714. 2007
    ..We examined Wolbachia population dynamics during testis development of Drosophila simulans (Riverside) by studying their distribution during the early mitotic divisions of secondary spermatogonial ..
  98. ncbi Bacteriophage flux in endosymbionts (Wolbachia): infection frequency, lateral transfer, and recombination rates
    Seth R Bordenstein
    The Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, USA
    Mol Biol Evol 21:1981-91. 2004
    ..WO underwent recent lateral transfers between Wolbachia bacteria that coinfect host cells in the dipteran Drosophila simulans and the hymenopteran Nasonia vitripennis...
  99. pmc Genetic and functional characterization of the type IV secretion system in Wolbachia
    Edwige Rancès
    Universite de Lyon, Lyon, France
    J Bacteriol 190:5020-30. 2008
    ..genome of Wolbachia pipientis strain wAtab3, from the Hymenoptera Asobara tabida, and strain wRi, infecting Drosophila simulans. One operon consisted of five vir genes (virB8, virB9, virB10, virB11, and virD4) and the downstream wspB ..
  100. pmc A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter
    Yun Tao
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 5:e293. 2007
    ..Here we characterize a sex-ratio distorter on the X chromosome (Dox) in Drosophila simulans by genetic and molecular means. Intriguingly, Dox has very limited coding capacity...
  101. pmc Neutral and non-neutral evolution of Drosophila mitochondrial DNA
    D M Rand
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912
    Genetics 138:741-56. 1994
    ..gene in the mitochondrial DNA of 29 lines of Drosophila melanogaster and 9 lines of its sibling species Drosophila simulans. In contrast to the patterns for nuclear genes, where D...

Research Grants22

  1. Molecular basis of reproductive isolation in Drosophila
    AMANDA MOEHRING; Fiscal Year: 2007
    ..were previously indicated through quantitative trait locus mapping affecting copulation occurrence between Drosophila simulans and D...
  2. Daniel A Barbash; Fiscal Year: 2016
    ..and Lhr, which interact to cause hybrid lethality between the fruit fly species Drosophila melanogaster and Drosophila simulans. A major goal is to understand how these genes kill hybrids, and how the interaction between them is ..
  3. Daven C Presgraves; Fiscal Year: 2015
    ....
  4. Clade-specific changes in transcription of olfactory genes in fruit flies
    EREZYILMAZ DENIZ; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The Drosophila simulans clade diverged from the D. melanogaster lineage about 3 million years ago and radiated to produce D. simulans and D. sechellia. While D. melanogaster and D...
  5. Empirical analysis of natural selection on codon usage in eukaryotes
    RICHARD KLIMAN; Fiscal Year: 2007
    ..genes, sequenced from start through stop codon, is currently being generated for four strains of Drosophila simulans, five strains of D. mauritiana and one strain of D. sechellia...
  6. POPULATION GENETICS OF D SIMULANS AND D MELANOGASTER
    DAVID BEGUN; Fiscal Year: 2001
    ..They will take the form of DNA sequences from small population samples of Drosophila simulans and its close relative, melanogaster...
  7. Genetic Basis of Posterior Lobe Evolution in Drosophila
    Barry Williams; Fiscal Year: 2005
    ..6 - 0.9 million years) species of Drosophila simulans and D...
  8. The evolution of gene expression in Drosophila
    COLIN MEIKLEJOHN; Fiscal Year: 2007
    ..will be initiated by experiments designed to measure gene expression across the genome for genotypes of Drosophila simulans that have had a segment of their genome replaced with the homologous segment from the closely related ..
  9. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  10. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2008
    ..abstract_text> ..
  11. Drosophila simulans as a model for aging research
    John Ballard; Fiscal Year: 2002
    The goal of the proposal is to investigate the potential for Drosophila simulans to be a new and informative model for aging research...
  12. EVOLUTIONARY GENETICS OF MALE REPRODUCTIVE TRAITS IN MUS
    MATTHEW DEAN; Fiscal Year: 2006
    ..These studies will help uncover the genetic basis of male reproductive fitness in a natural population of house mice. [unreadable] [unreadable]..
  13. Immunity to a Parasitoid Wasp in Drosophila melanogaster
    Todd Schlenke; Fiscal Year: 2005
    ....
  14. Vector Population Modification Using Wolbachia Symbionts
    Stephen Dobson; Fiscal Year: 2006
    ..g., maternal transmission rates and Wolbachia effects on host fitness), simplifying discrimination between Culex infection types, and improving methods for field cage evaluation of Wolbachia control strategies. ..
  15. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    STEPHEN LEONARD DOBSON; Fiscal Year: 2010
    ..Integration of the vector eradication strategy and the MDA approach will facilitate filariasis elimination in areas where MDA alone has failed. ..
  16. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  17. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  18. Ecology, genetics and physiology of insect vectors
    Elliot Krafsur; Fiscal Year: 2006
    ..abstract_text> ..
  19. Identification of circadian clock output genes
    Mark Drapeau; Fiscal Year: 2006
    ..Then, some of these genes will be studied molecularly to determine how they are regulated by the central clock. ..
  20. RNAi Mediated Gene Disruption in Caenorhabditis Elegans
    Wayne Van Voorhies; Fiscal Year: 2006
    ..Such worms could identify candidate genes affecting processes that act "downstream" from the metabolic rate and provide valuable insights into the causes of aging and mechanisms by which it can be attenuated. ..
  21. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  22. METABOLIC CONTROL AND MOLECULAR ADAPTATION IN DROSOPHILA
    WALTER EANES; Fiscal Year: 2005
    ..Studies will begin to identify the genes responsible for the variation in this suite of traits that have cascading effects into the metabolic pathways. ..

Patents10

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
    Patent Number: JP2016507218-A; Date:2016-03-10
  2. Method of identifying eukaryotic species
    Patent Number: JP2014155500-A; Date:2014-08-28
  3. SNORNA, COMPOSITIONS AND USES
    Patent Number: WO2015067727-A1; Date:2015-05-14
  4. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  5. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  6. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  7. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  8. Method of preparating merkmal for distinguishing insect
    Patent Number: JP2008099644-A; Date:2008-05-01
  9. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  10. Method of identifying eukaryotic species
    Patent Number: JP2010088398-A; Date:2010-04-22