fruit fly

Summary

Alias: Drosophila melanogaster, Drosophila melangaster, Drosophila melanogaster Meigen, 1830

Top Publications

  1. LING F, Dahanukar A, Weiss L, Kwon J, Carlson J. The molecular and cellular basis of taste coding in the legs of Drosophila. J Neurosci. 2014;34:7148-64 pubmed publisher
    ..Although the labellum of the Drosophila melanogaster head has been described in detail, the tarsal segments of the legs, which collectively contain more taste ..
  2. Mohn F, Sienski G, Handler D, Brennecke J. The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell. 2014;157:1364-79 pubmed publisher
    ..Likely, this process involves 5' end protection of nascent RNAs and suppression of transcription termination. Our data provide key insight into the regulation and evolution of piRNA clusters...
  3. Matute D, Gavin Smyth J, Liu G. Variable post-zygotic isolation in Drosophila melanogaster/D. simulans hybrids. J Evol Biol. 2014;27:1691-705 pubmed publisher
    ..the effects of natural variation on the penetrance of hybrid inviability phenotypes in crosses between Drosophila melanogaster and two species of the D. simulans subcomplex, D. simulans and D. sechellia...
  4. Martinez J, Longdon B, Bauer S, Chan Y, Miller W, Bourtzis K, et al. Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains. PLoS Pathog. 2014;10:e1004369 pubmed publisher
    ..The large variation in Wolbachia's antiviral properties highlights the need to carefully select Wolbachia strains introduced into mosquito populations to prevent the transmission of arboviruses...
  5. Yamamoto S, Jaiswal M, Charng W, Gambin T, Karaca E, Mirzaa G, et al. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014;159:200-214 pubmed publisher
    ..This bidirectional synergism between fly genetics and human genomics facilitates the functional annotation of evolutionarily conserved genes involved in human health...
  6. Fujita N, Nagata Y, Nishiuchi T, Sato M, Iwami M, Kiya T. Visualization of neural activity in insect brains using a conserved immediate early gene, Hr38. Curr Biol. 2013;23:2063-70 pubmed publisher
    ..We found that Hr38 can also be used as a neural activity marker in the fly Drosophila melanogaster. Using Hr38, we constructed a neural activity map of the fly brain that partially overlaps with ..
  7. Law A, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, et al. Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013;203:673-89 pubmed publisher
    ..Further, Lpd's Drosophila melanogaster orthologue Pico binds Scar, and both regulate collective epithelial border cell migration...
  8. Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol. 2013;203:575-83 pubmed publisher
    ..Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling...
  9. Roy S, Huang H, Liu S, Kornberg T. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science. 2014;343:1244624 pubmed publisher
    ....
  10. Harrop T, Sztal T, Lumb C, Good R, Daborn P, Batterham P, et al. Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila. PLoS ONE. 2014;9:e84879 pubmed publisher
    ..In some populations, resistance has evolved to multiple pesticides. In Drosophila melanogaster, resistance to multiple classes of insecticide is due to the overexpression of a single cytochrome P450 ..

Detail Information

Publications108 found, 100 shown here

  1. LING F, Dahanukar A, Weiss L, Kwon J, Carlson J. The molecular and cellular basis of taste coding in the legs of Drosophila. J Neurosci. 2014;34:7148-64 pubmed publisher
    ..Although the labellum of the Drosophila melanogaster head has been described in detail, the tarsal segments of the legs, which collectively contain more taste ..
  2. Mohn F, Sienski G, Handler D, Brennecke J. The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell. 2014;157:1364-79 pubmed publisher
    ..Likely, this process involves 5' end protection of nascent RNAs and suppression of transcription termination. Our data provide key insight into the regulation and evolution of piRNA clusters...
  3. Matute D, Gavin Smyth J, Liu G. Variable post-zygotic isolation in Drosophila melanogaster/D. simulans hybrids. J Evol Biol. 2014;27:1691-705 pubmed publisher
    ..the effects of natural variation on the penetrance of hybrid inviability phenotypes in crosses between Drosophila melanogaster and two species of the D. simulans subcomplex, D. simulans and D. sechellia...
  4. Martinez J, Longdon B, Bauer S, Chan Y, Miller W, Bourtzis K, et al. Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains. PLoS Pathog. 2014;10:e1004369 pubmed publisher
    ..The large variation in Wolbachia's antiviral properties highlights the need to carefully select Wolbachia strains introduced into mosquito populations to prevent the transmission of arboviruses...
  5. Yamamoto S, Jaiswal M, Charng W, Gambin T, Karaca E, Mirzaa G, et al. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014;159:200-214 pubmed publisher
    ..This bidirectional synergism between fly genetics and human genomics facilitates the functional annotation of evolutionarily conserved genes involved in human health...
  6. Fujita N, Nagata Y, Nishiuchi T, Sato M, Iwami M, Kiya T. Visualization of neural activity in insect brains using a conserved immediate early gene, Hr38. Curr Biol. 2013;23:2063-70 pubmed publisher
    ..We found that Hr38 can also be used as a neural activity marker in the fly Drosophila melanogaster. Using Hr38, we constructed a neural activity map of the fly brain that partially overlaps with ..
  7. Law A, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, et al. Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013;203:673-89 pubmed publisher
    ..Further, Lpd's Drosophila melanogaster orthologue Pico binds Scar, and both regulate collective epithelial border cell migration...
  8. Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol. 2013;203:575-83 pubmed publisher
    ..Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling...
  9. Roy S, Huang H, Liu S, Kornberg T. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science. 2014;343:1244624 pubmed publisher
    ....
  10. Harrop T, Sztal T, Lumb C, Good R, Daborn P, Batterham P, et al. Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila. PLoS ONE. 2014;9:e84879 pubmed publisher
    ..In some populations, resistance has evolved to multiple pesticides. In Drosophila melanogaster, resistance to multiple classes of insecticide is due to the overexpression of a single cytochrome P450 ..
  11. Hall S, Bone C, Oshima K, Zhang L, McGraw M, Lucas B, et al. Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila. Development. 2014;141:889-98 pubmed publisher
    ..Together, these studies demonstrate that Mcr is a core component of epithelial SJs and also highlight an interesting relationship between innate immunity and epithelial barrier functions. ..
  12. Collins K, Unruh J, Slaughter B, Yu Z, Lake C, Nielsen R, et al. Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila. Genetics. 2014;198:219-28 pubmed publisher
    ..Here, we report the identification of a novel SC component in Drosophila melanogaster female oocytes, which we have named Corolla...
  13. Wentzell J, Cassar M, Kretzschmar D. Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration. PLoS ONE. 2014;9:e87526 pubmed publisher
    ..We therefore propose a model in which OP-modified SWS cannot release PKA-C3 and that the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of OPIDN but not in the acute toxicity. ..
  14. Martin I, Kim J, Lee B, Kang H, Xu J, Jia H, et al. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014;157:472-485 pubmed publisher
    ..These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo. ..
  15. Lawton K, Wassmer T, Deitcher D. Conserved role of Drosophila melanogaster FoxP in motor coordination and courtship song. Behav Brain Res. 2014;268:213-21 pubmed publisher
    ..The recent discovery of the well-conserved Drosophila melanogaster homolog, FoxP, provides an opportunity to study the role of this crucial gene in an invertebrate model...
  16. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet. 2014;10:e1004391 pubmed publisher
    ....
  17. Chen Z, Sturgill D, Qu J, Jiang H, Park S, Boley N, et al. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome Res. 2014;24:1209-23 pubmed publisher
    ..We report that the vast majority of elements in the annotation are evolutionarily conserved, indicating that the annotation will be an important springboard for functional genetic testing by the Drosophila community. ..
  18. Paemka L, Mahajan V, Skeie J, Sowers L, Ehaideb S, Gonzalez Alegre P, et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS ONE. 2013;8:e80737 pubmed publisher
    ..Taken together, these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. ..
  19. Favrin G, Bean D, Bilsland E, Boyer H, Fischer B, Russell S, et al. Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Sci Rep. 2013;3:3512 pubmed publisher
    ..In particular, we uncovered two new modifiers of the Aβ phenotype, namely Sod3 and PGRP-SC1b. ..
  20. Ghosh A, Kling T, Snaidero N, Sampaio J, Shevchenko A, Gras H, et al. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. PLoS Genet. 2013;9:e1003980 pubmed publisher
    ..Supplementing sphingosine into the diet rescued the neuropathy in flies. Thus, our RNAi study in Drosophila identifies a key role of ceramide phosphoethanolamine in wrapping of axons by glia. ..
  21. Berger Müller S, Sugie A, Takahashi F, Tavosanis G, Hakeda Suzuki S, Suzuki T. Assessing the role of cell-surface molecules in central synaptogenesis in the Drosophila visual system. PLoS ONE. 2013;8:e83732 pubmed publisher
    ....
  22. Nefedova L, Kuzmin I, Makhnovskii P, Kim A. Domesticated retroviral GAG gene in Drosophila: new functions for an old gene. Virology. 2014;450-451:196-204 pubmed publisher
    ..In this study, we focused on the domesticated retroviral gag gene homolog (Grp) in the Drosophila melanogaster genome...
  23. Xu Z, Chen H, Ling J, Yu D, Struffi P, Small S. Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila. Genes Dev. 2014;28:608-21 pubmed publisher
    ..These results underscore the importance of combinatorial binding in enhancer function and provide data that will help predict regulatory activities based on DNA sequence. ..
  24. Soundararajan H, Bullock S. The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA. elife. 2014;3:e01596 pubmed publisher
    ..DOI: http://dx.doi.org/10.7554/eLife.01596.001. ..
  25. Fischer S, Blanchard G, Duque J, Adams R, Arias A, Guest S, et al. Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics. PLoS ONE. 2014;9:e95695 pubmed publisher
    ....
  26. Rosenbaum E, Vasiljevic E, Brehm K, Colley N. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. PLoS Genet. 2014;10:e1004349 pubmed publisher
    ..The major rhodopsin in Drosophila melanogaster photoreceptors, Rh1, is highly unique among glycoproteins, as the N-glycan appears to be completely ..
  27. Kalb R, Latwiel S, Baymaz H, Jansen P, Müller C, Vermeulen M, et al. Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression. Nat Struct Mol Biol. 2014;21:569-71 pubmed publisher
    ..Jarid2, Aebp2 and H2Aub thus constitute components of a positive feedback loop establishing H3K27me3 chromatin domains. ..
  28. Arnold C, Gerlach D, Spies D, Matts J, Sytnikova Y, Pagani M, et al. Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution. Nat Genet. 2014;46:685-92 pubmed publisher
    ..enhancer activity profiles for five Drosophila species in the constant trans-regulatory environment of Drosophila melanogaster S2 cells. We find that the functions of a large fraction of D...
  29. Vogt K, Schnaitmann C, Dylla K, Knapek S, Aso Y, Rubin G, et al. Shared mushroom body circuits underlie visual and olfactory memories in Drosophila. elife. 2014;3:e02395 pubmed publisher
    ..Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs. ..
  30. Wang C, Chen G, Chien C. The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development. Biochem Biophys Res Commun. 2014;452:369-75 pubmed publisher
    ..Ultimately, the failure to fully compensate the dysfunctional proteasome in leon mutants leads to animal lethality and tissue disorder. ..
  31. Oas S, Bryantsev A, Cripps R. Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila. J Cell Biol. 2014;206:895-908 pubmed publisher
    b>Drosophila melanogaster flight muscles are distinct from other skeletal muscles, such as jump muscles, and express several uniquely spliced muscle-associated transcripts...
  32. Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner S, Leser K, et al. tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS ONE. 2014;9:e108267 pubmed publisher
    ....
  33. Alfieri C, Gambetta M, Matos R, Glatt S, Sehr P, Fraterman S, et al. Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Genes Dev. 2013;27:2367-79 pubmed publisher
    ..Our results support a model where DNA tethering of Sfmbt by Pho and multivalent interactions of Sfmbt with histone modifications and other PcG proteins create a hub for PcG protein complex assembly at PREs. ..
  34. Krstic D, Boll W, Noll M. Influence of the White locus on the courtship behavior of Drosophila males. PLoS ONE. 2013;8:e77904 pubmed publisher
    ..Implications of these findings for the proper interpretation of behavioral studies with white mutant flies are discussed. ..
  35. Komori H, Xiao Q, McCartney B, Lee C. Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development. 2014;141:51-62 pubmed publisher
    ..Thus, the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu in the presumptive intermediate progenitor cell by attenuating Arm activity, balancing stem cell maintenance and progenitor cell specification. ..
  36. Han C, Song Y, Xiao H, Wang D, Franc N, Jan L, et al. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014;81:544-560 pubmed publisher
    ..Our finding reveals the physiological importance of coordination between neurons and their surrounding epidermis, for both dendrite fragmentation and clearance. ..
  37. Linneweber G, Jacobson J, Busch K, Hudry B, Christov C, Dormann D, et al. Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching. Cell. 2014;156:69-83 pubmed publisher
    ..Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture. ..
  38. Ming M, Obata F, Kuranaga E, Miura M. Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila. J Biol Chem. 2014;289:7558-68 pubmed publisher
    ..Our findings show that the Persephone proteolytic cascade plays a crucial role in mediating DAMP-induced systemic responses in apoptosis-deficient Drosophila mutants. ..
  39. Ahmad S, Busser B, Huang D, Cozart E, Michaud S, Zhu X, et al. Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification. Development. 2014;141:878-88 pubmed publisher
    ....
  40. LaFlamme B, Avila F, Michalski K, Wolfner M. A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity. Genetics. 2014;196:1117-29 pubmed publisher
    ..We previously reported the existence of a proteolytic cascade in Drosophila melanogaster seminal fluid that is initiated in the male and ends in the female...
  41. Yatsenko A, Shcherbata H. Drosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation. Dev Cell. 2014;28:335-48 pubmed publisher
    ....
  42. Wylie A, Lu W, D Brot A, Buszczak M, Abrams J. p53 activity is selectively licensed in the Drosophila stem cell compartment. elife. 2014;3:e01530 pubmed publisher
    ..Furthermore, the findings uncover ancestral links between p53 and aberrant proliferation that are independent of DNA breaks and predate evolution of the ARF/Mdm2 axis. DOI: http://dx.doi.org/10.7554/eLife.01530.001. ..
  43. Vijayan V, Thistle R, Liu T, Starostina E, Pikielny C. Drosophila pheromone-sensing neurons expressing the ppk25 ion channel subunit stimulate male courtship and female receptivity. PLoS Genet. 2014;10:e1004238 pubmed publisher
    ..While ppk25 neurons are required for the responses to multiple pheromones, in both males and females these neurons are specifically involved in stimulating courtship and mating. ..
  44. Martins N, Faria V, Nolte V, Schlotterer C, Teixeira L, Sucena E, et al. Host adaptation to viruses relies on few genes with different cross-resistance properties. Proc Natl Acad Sci U S A. 2014;111:5938-43 pubmed publisher
    ..We determined the genetic and phenotypic changes underlying adaptation of Drosophila melanogaster to Drosophila C virus (DCV)...
  45. Dong B, Hannezo E, Hayashi S. Balance between apical membrane growth and luminal matrix resistance determines epithelial tubule shape. Cell Rep. 2014;7:941-50 pubmed publisher
    ..Our findings demonstrate a mechanical role for the extracellular matrix and suggest that the interaction of the apical membrane and an elastic aECM determines the final morphology of biological tubes independent of cell shape. ..
  46. Vartiainen S, Chen S, George J, Tuomela T, Luoto K, O Dell K, et al. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Dis Model Mech. 2014;7:635-48 pubmed publisher
    ..Our findings illustrate the potential of different therapeutic strategies for ANT-linked diseases, based on alleviating metabolic stress. ..
  47. Chihara T, Kitabayashi A, Morimoto M, Takeuchi K, Masuyama K, Tonoki A, et al. Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila. PLoS Genet. 2014;10:e1004437 pubmed publisher
    ....
  48. Nogueira C, Kashevsky H, Pinto B, Clarke A, Orr Weaver T. Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis. G3 (Bethesda). 2014;4:1849-58 pubmed publisher
    ..We investigated these questions in Drosophila melanogaster, an organism with superb chromosome cytology to monitor Sgo localization and quantitative assays to test ..
  49. Chtarbanova S, Lamiable O, Lee K, Galiana D, Troxler L, Meignin C, et al. Drosophila C virus systemic infection leads to intestinal obstruction. J Virol. 2014;88:14057-69 pubmed publisher
    ..This natural pathogen of the model organism Drosophila melanogaster is commonly used to investigate antiviral host defense in flies, which involves both RNA interference and ..
  50. Zhou Q, Zhang T, Jemc J, Chen Y, Chen R, Rebay I, et al. Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. Dev Biol. 2014;386:152-64 pubmed publisher
    ..Our study suggests that Ey and So operate differently through the same 3' cis-regulatory sites in distinct populations of retinal progenitors. ..
  51. Hunter G, Crawford J, Genkins J, Kiehart D. Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. Development. 2014;141:325-34 pubmed publisher
    ..Our results point to a key role for ion channels in closure, and suggest a mechanism for the coordination of force-producing cell behaviors across the embryo. ..
  52. Domanitskaya E, Anllo L, Schupbach T. Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev Biol. 2014;386:408-18 pubmed publisher
    ..This "egg chamber autonomous" ecdysone synthesis constitutes a useful way to regulate the individual maturation of the asynchronous egg chambers present in the Drosophila ovary. ..
  53. Alic N, Tullet J, Niccoli T, Broughton S, Hoddinott M, Slack C, et al. Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Rep. 2014;6:608-16 pubmed publisher
    b>Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively...
  54. Ghavi Helm Y, Klein F, Pakozdi T, Ciglar L, Noordermeer D, Huber W, et al. Enhancer loops appear stable during development and are associated with paused polymerase. Nature. 2014;512:96-100 pubmed publisher
    ..Our results indicate that the general topology governing enhancer contacts is conserved from flies to humans and suggest that transcription initiates from preformed enhancer-promoter loops through release of paused polymerase. ..
  55. Marley R, Giachello C, Scrutton N, Baines R, Jones A. Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae. Sci Rep. 2014;4:5799 pubmed publisher
    ....
  56. Liu X, Greer C, Secombe J. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. PLoS Genet. 2014;10:e1004676 pubmed publisher
    ..Significantly, this occurs independently of KDM5's well-characterized demethylase activity. Instead, KDM5 interacts with the lysine deacetylase HDAC4 to promote Foxo deacetylation, which affects Foxo DNA binding. ..
  57. Zhang Q, Shalaby N, Buszczak M. Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage. Science. 2014;343:298-301 pubmed publisher
    ..These findings demonstrate that modulating rRNA synthesis fosters changes in the cell fate, growth, and proliferation of female Drosophila GSCs and their daughters. ..
  58. Moskalev A, Shaposhnikov M, Snezhkina A, Kogan V, Plyusnina E, Peregudova D, et al. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. PLoS ONE. 2014;9:e86051 pubmed publisher
    ..This study examines genome-wide gene expression profiles of Drosophila melanogaster in response to ionizing radiation, formaldehyde, toluene, and 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  59. Okenve Ramos P, Llimargas M. Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis. Development. 2014;141:929-39 pubmed publisher
    ....
  60. Fan Y, Wang S, Hernandez J, Yenigun V, Hertlein G, Fogarty C, et al. Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila. PLoS Genet. 2014;10:e1004131 pubmed publisher
    ..These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation. ..
  61. Binggeli O, Neyen C, Poidevin M, Lemaitre B. Prophenoloxidase activation is required for survival to microbial infections in Drosophila. PLoS Pathog. 2014;10:e1004067 pubmed publisher
    ..Our study also reveals an important role for PPO1 and PPO2 in the survival to infection with Gram-positive bacteria and fungi, underlining the importance of melanization in insect host defense. ..
  62. Ivshina M, Lasko P, Richter J. Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annu Rev Cell Dev Biol. 2014;30:393-415 pubmed publisher
    ..We review the biochemical features of the CPEB proteins, discuss their activities in several biological systems, and illustrate how understanding CPEB activity in model organisms has an important impact on neurological disease. ..
  63. Matis M, Russler Germain D, Hu Q, Tomlin C, Axelrod J. Microtubules provide directional information for core PCP function. elife. 2014;3:e02893 pubmed publisher
    ..Together, these results support the hypothesis that Ft/Ds/Fj provides a signal to orient core PCP function via MT polarization. ..
  64. Guarner A, Manjón C, Edwards K, Steller H, Suzanne M, Sánchez Herrero E. The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments. Dev Biol. 2014;385:350-65 pubmed publisher
    ..Our results demonstrate the key role of zfh-2 in the control of cell death and Notch signaling during leg development. ..
  65. Giuliani G, Giuliani F, Volk T, Rabouille C. The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium. Nucleic Acids Res. 2014;42:1970-86 pubmed publisher
    ....
  66. Ramos A, Barolo S. Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution. Philos Trans R Soc Lond B Biol Sci. 2013;368:20130018 pubmed publisher
    ..We propose that the requirement for gene activation by Ci in the regions of low-to-moderate Hh signalling results in evolutionary pressure favouring weak binding sites in enhancers of certain Hh target genes. ..
  67. Moustaqim Barrette A, Lin Y, Pradhan S, Neely G, Bellen H, Tsuda H. The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Hum Mol Genet. 2014;23:1975-89 pubmed publisher
    ..Hence, we propose that the ALS8 mutation impairs the interaction of Vap with Osbp, resulting in hypomorphic defects that might contribute to the pathology of ALS8. ..
  68. Figard L, Xu H, Garcia H, Golding I, Sokac A. The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization. Dev Cell. 2013;27:648-55 pubmed publisher
    ..We conclude that plasma membrane folding/unfolding can contribute to the cell-shape changes that promote embryonic morphogenesis. ..
  69. Christophorou N, Rubin T, Huynh J. Synaptonemal complex components promote centromere pairing in pre-meiotic germ cells. PLoS Genet. 2013;9:e1004012 pubmed publisher
    ..Our results thus show that meiotic proteins and meiotic organization of centromeres, which are key features to ensure reductional segregation, are laid out in amplifying germ cells, before meiosis has started. ..
  70. Vittori A, Breda C, Repici M, Orth M, Roos R, Outeiro T, et al. Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Hum Mol Genet. 2014;23:3129-37 pubmed publisher
    ..Furthermore, we found that increasing dosage of Glut1-the Drosophila melanogaster homologue of this glucose transporter-ameliorated HD-relevant phenotypes in fruit flies, including ..
  71. Song M, Zhang Y, Katzaroff A, Edgar B, Buttitta L. Hunting complex differential gene interaction patterns across molecular contexts. Nucleic Acids Res. 2014;42:e57 pubmed publisher
    ..We applied CPχ(2) to Drosophila melanogaster wing gene expression arrays collected under normal conditions, and conditions with overexpressed E2F and ..
  72. Liang J, Lacroix L, Gamot A, Cuddapah S, Queille S, Lhoumaud P, et al. Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing. Mol Cell. 2014;53:672-81 pubmed publisher
    ..Our data illustrate how indirect peaks may decipher gene regulatory networks through specific long-range interactions. ..
  73. Johnston R, Desplan C. Interchromosomal communication coordinates intrinsically stochastic expression between alleles. Science. 2014;343:661-5 pubmed publisher
    ..Therefore, although individual ss alleles make independent stochastic choices, interchromosomal communication coordinates expression state between alleles, ensuring that they are both expressed in the same random subset of R7s. ..
  74. Itsara L, Kennedy S, Fox E, Yu S, Hewitt J, Sánchez Contreras M, et al. Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations. PLoS Genet. 2014;10:e1003974 pubmed publisher
    ..assay to characterize the age-dependent frequency and distribution of mtDNA mutations in the fruit fly Drosophila melanogaster. Because oxidative stress is a major suspect in the age-dependent accumulation of somatic mtDNA mutations,..
  75. Da Re C, De Pittà C, Zordan M, Teza G, Nestola F, Zeviani M, et al. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. EMBO Rep. 2014;15:586-91 pubmed publisher
    Larvae of Drosophila melanogaster reared at 23°C and switched to 14°C for 1 h are 0.5°C warmer than the surrounding medium...
  76. Messina G, Damia E, Fanti L, Atterrato M, Celauro E, Mariotti F, et al. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 2014;127:2577-88 pubmed publisher
    ..Using Drosophila melanogaster as a model organism, we investigated the in vivo role of the Drosophila BCNT member called YETI...
  77. Xue Z, Ren M, Wu M, Dai J, Rong Y, Gao G. Efficient gene knock-out and knock-in with transgenic Cas9 in Drosophila. G3 (Bethesda). 2014;4:925-9 pubmed publisher
    ..5% by co-injecting gRNA with a circular DNA donor. ..
  78. Vazquez Pianzola P, Adam J, Haldemann D, Hain D, Urlaub H, Suter B. Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D. Development. 2014;141:1915-26 pubmed publisher
    ..Moreover, we also uncovered a novel, presumably endocytosis-independent, role of Chc in the establishment of microtubule polarity in stage 6 oocytes. ..
  79. Pecot M, Chen Y, Akin O, Chen Z, Tsui C, Zipursky S. Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system. Neuron. 2014;82:320-33 pubmed publisher
    ..We propose that a cascade of axon-derived signals, regulating diverse cellular processes, provides a strategy for coordinating circuit assembly across different regions of the nervous system. ..
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    ..Finally we show that mammalian homologs of Ey and Da can functionally replace their Drosophila counterparts to synergistically activate the Ato enhancer, suggesting that the observed function is evolutionary conserved. ..
  81. Schoofs A, Hückesfeld S, Surendran S, Pankratz M. Serotonergic pathways in the Drosophila larval enteric nervous system. J Insect Physiol. 2014;69:118-25 pubmed publisher
    ..We suggest that the axonal projections of this serotonergic cluster may be part of a brain-gut neural pathway that is functionally analogous to the vertebrate vagus nerve. ..
  82. Moreno E, Rhiner C. Darwin's multicellularity: from neurotrophic theories and cell competition to fitness fingerprints. Curr Opin Cell Biol. 2014;31:16-22 pubmed publisher
    ....
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    ..Data suggest that Spz functions with neuron-type specificity at the muscle 4 NMJ, and DNT1 and DNT2 function together at the muscles 6,7 NMJ. ..
  84. Jin Y, Xu J, Yin M, Lu Y, Hu L, Li P, et al. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. elife. 2013;2:e00999 pubmed publisher
    ..Our findings highlighted the importance of Hpo signaling in regulating epigenetic components such as Brm to control downstream transcription and hence ISC proliferation. DOI:http://dx.doi.org/10.7554/eLife.00999.001. ..
  85. Garcia H, Tikhonov M, Lin A, Gregor T. Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning. Curr Biol. 2013;23:2140-5 pubmed publisher
    ..Thus, developmental patterns are not just the consequence of reproducible transcriptional dynamics in individual nuclei, but are the result of averaging expression over space and time. ..
  86. Moeller M, Danielsen E, Herder R, O Connor M, Rewitz K. Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila. Development. 2013;140:4730-9 pubmed publisher
    ..Activation of this switch-like mechanism ensures a rapid, self-limiting PG response that functions in producing steroid oscillations that can guide the decision to terminate growth and promote maturation. ..
  87. Shirangi T, Stern D, Truman J. Motor control of Drosophila courtship song. Cell Rep. 2013;5:678-86 pubmed publisher
    Many animals utilize acoustic signals-or songs-to attract mates. During courtship, Drosophila melanogaster males vibrate a wing to produce trains of pulses and extended tone, called pulse and sine song, respectively...
  88. Corty M, Freeman M. Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity. J Cell Biol. 2013;203:395-405 pubmed publisher
    ..Recent findings illustrate the importance of glial cells in shaping the nervous system by controlling the number and connectivity of neurons. ..
  89. Wu C, Shih M, Lee P, Chiang A. An octopamine-mushroom body circuit modulates the formation of anesthesia-resistant memory in Drosophila. Curr Biol. 2013;23:2346-54 pubmed publisher
    ..Additive effects suggest that two parallel ARM pathways, serotoninergic DPM-αβ KCs and octopaminergic APL-α'β' KCs, exist in the MB. ..
  90. Riemensperger T, Issa A, Pech U, Coulom H, Nguyễn M, Cassar M, et al. A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 2013;5:952-60 pubmed publisher
    ..This suggests that modulation of the mushroom body β' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies. ..
  91. Zheng L, Sepúlveda L, Lua R, Lichtarge O, Golding I, Sokac A. The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis. PLoS Genet. 2013;9:e1003901 pubmed publisher
    ..Since all morphogenesis depends on cytoskeletal remodeling, both in embryos and adults, we suggest that robustness-promoting mechanisms aimed at actin could be effective at all life stages. ..
  92. Yang C, Sinenko S, Thomenius M, Robeson A, Freel C, Horn S, et al. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Cell Death Differ. 2014;21:604-11 pubmed publisher
    ..DUBAI, therefore, represents a novel locus of apoptotic regulation in Drosophila, antagonizing cell death signals that would otherwise result in DIAP1 degradation. ..
  93. Da Re C, Franzolin E, Biscontin A, Piazzesi A, Pacchioni B, Gagliani M, et al. Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. J Biol Chem. 2014;289:7448-59 pubmed publisher
    The CG18317 gene (drim2) is the Drosophila melanogaster homolog of the Saccharomyces cerevisiae Rim2 gene, which encodes a pyrimidine (deoxy)nucleotide carrier...
  94. Klinker H, Mueller Planitz F, Yang R, Forne I, Liu C, Nordenskiöld L, et al. ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4. PLoS ONE. 2014;9:e88411 pubmed publisher
    ..Therefore, the effect of H4K16 acetylation on ISWI remodelling depends on the precise nature of the substrate. ..
  95. Bulgari D, Zhou C, Hewes R, Deitcher D, Levitan E. Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals. Proc Natl Acad Sci U S A. 2014;111:3597-601 pubmed publisher
    ..Therefore, DCV capture in the terminal is genetically controlled and determines neuron-specific variation in peptidergic function. ..
  96. Parisi F, Stefanatos R, Strathdee K, Yu Y, Vidal M. Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of Toll and Eiger/TNF signaling. Cell Rep. 2014;6:855-67 pubmed publisher
    ..Altogether, our results provide a paradigm for a long-range tumor suppression function of adipocytes in Drosophila, which may represent an evolutionarily conserved mechanism in the organismal response to solid tumors. ..
  97. Eliazer S, Palacios V, Wang Z, Kollipara R, Kittler R, Buszczak M. Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. PLoS Genet. 2014;10:e1004200 pubmed publisher
    ....
  98. Morais V, Haddad D, Craessaerts K, De Bock P, Swerts J, Vilain S, et al. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014;344:203-7 pubmed publisher
    ..Thus, this evolutionary conserved pathway may contribute to the pathogenic cascade that eventually leads to Parkinson's disease in patients with PINK1 mutations...
  99. Wei K, Clark A, Barbash D. Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans. Mol Biol Evol. 2014;31:1767-78 pubmed publisher
    ..Here, we use RNA-Seq to profile gene expression in F1 hybrid male larvae from crosses of Drosophila melanogaster to its sibling species D. simulans...
  100. Huang J, Kalderon D. Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation. J Cell Biol. 2014;205:325-38 pubmed publisher
    ..In this paper, we show that Hedgehog (Hh) signaling in Drosophila melanogaster ovarian follicle stem cells (FSCs) induces the activity of Yorkie (Yki), the transcriptional coactivator ..
  101. Zhou C, Pan Y, ROBINETT C, Meissner G, Baker B. Central brain neurons expressing doublesex regulate female receptivity in Drosophila. Neuron. 2014;83:149-63 pubmed publisher
    b>Drosophila melanogaster females respond to male courtship by either rejecting the male or allowing copulation. The neural mechanisms underlying these female behaviors likely involve the integration of sensory information in the brain...