Alias: viruses, Vira, Viridae

Top Publications

  1. ncbi The next influenza pandemic: lessons from Hong Kong
    K F Shortridge
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Appl Microbiol 94:70S-79S. 2003
  2. ncbi Application of transmission electron microscopy to the clinical study of viral and bacterial infections: present and future
    Alan Curry
    Health Protection Agency, Clinical Sciences Building, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Micron 37:91-106. 2006
  3. pmc The evolution of human influenza A viruses from 1999 to 2006: a complete genome study
    Karoline Bragstad
    Laboratory of Virus Research and Development, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Virol J 5:40. 2008
  4. doi Nobel Prizes and the emerging virus concept
    Erling Norrby
    Center for the History of Science, The Royal Swedish Academy of Sciences, Stockholm, Sweden
    Arch Virol 153:1109-23. 2008
  5. doi Detection and molecular characterization of enteric viruses from poult enteritis syndrome in turkeys
    N Jindal
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Poult Sci 89:217-26. 2010
  6. ncbi Evolution of viral DNA-dependent RNA polymerases
    K C Sonntag
    Institut fur Medizinische Virologie, Universitat Heidelberg, FRG
    Virus Genes 11:271-84. 1995
  7. ncbi Tailed bacteriophages: the order caudovirales
    H W Ackermann
    Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada
    Adv Virus Res 51:135-201. 1998
  8. pmc Present and future arboviral threats
    Scott C Weaver
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Antiviral Res 85:328-45. 2010
  9. ncbi Infections and autoimmune diseases
    Jean Francois Bach
    Laboratoire d Immunologie, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Autoimmun 25:74-80. 2005
  10. pmc Influenza virus morphogenesis and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Virus Res 143:147-61. 2009

Research Grants

  1. Robert M Krug; Fiscal Year: 2016
  2. A novel assay for inhibitors of influenza A virus polymerase complex assembly
    Feng Li; Fiscal Year: 2009
  3. Bioavailable proteasome inhibitors as broad-spectrum antivirals
  4. The roles of acidic autophagosomes in production of infectious poliovirus
    William T Jackson; Fiscal Year: 2013
  5. Coronavirus RNA Replication
    DAVID ALVIN BRIAN; Fiscal Year: 2012
  6. Philip J Santangelo; Fiscal Year: 2014
  7. Hantavirus RNA Encapsidation and Packaging
    Antonito T Panganiban; Fiscal Year: 2012
  8. CAROLINA B LOPEZ; Fiscal Year: 2016
  9. Adolfo Garcia-Sastre; Fiscal Year: 2016
  10. Mechanism of inhibition of +RNA virus replication by cyclophilins
    Peter Nagy; Fiscal Year: 2012


  1. Recombinant Virus with diminished latency and methods of using same
  2. Production of bac vectors carrying viral genomes
  3. Construct system and uses therefor
  5. Means and methods for detecting protein-peptide interactions

Detail Information

Publications4473 found, 100 shown here

  1. ncbi The next influenza pandemic: lessons from Hong Kong
    K F Shortridge
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    J Appl Microbiol 94:70S-79S. 2003
    ..even higher order of baseline preparedness with the recognition in chicken of a range of genotypes of H5N1-like viruses before they had the opportunity to infect humans...
  2. ncbi Application of transmission electron microscopy to the clinical study of viral and bacterial infections: present and future
    Alan Curry
    Health Protection Agency, Clinical Sciences Building, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Micron 37:91-106. 2006
    Transmission electron microscopy has had a profound impact on our knowledge and understanding of viruses and bacteria...
  3. pmc The evolution of human influenza A viruses from 1999 to 2006: a complete genome study
    Karoline Bragstad
    Laboratory of Virus Research and Development, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Virol J 5:40. 2008
    Knowledge about the complete genome constellation of seasonal influenza A viruses from different countries is valuable for monitoring and understanding of the evolution and migration of strains...
  4. doi Nobel Prizes and the emerging virus concept
    Erling Norrby
    Center for the History of Science, The Royal Swedish Academy of Sciences, Stockholm, Sweden
    Arch Virol 153:1109-23. 2008
    ..After this discovery it took more than 50 years before a resilient definition of viruses could be given...
  5. doi Detection and molecular characterization of enteric viruses from poult enteritis syndrome in turkeys
    N Jindal
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Poult Sci 89:217-26. 2010
    This study was conducted to detect and characterize enteric viruses [rotavirus, turkey astrovirus-2 (TAstV-2), reovirus, and turkey coronavirus] from cases of poult enteritis syndrome (PES) in Minnesota turkeys...
  6. ncbi Evolution of viral DNA-dependent RNA polymerases
    K C Sonntag
    Institut fur Medizinische Virologie, Universitat Heidelberg, FRG
    Virus Genes 11:271-84. 1995
    ..enzyme of transcription of replicating systems of prokaryotic and eukaryotic organisms as well as cytoplasmic DNA viruses. DdRPs are complex multisubunit enzymes consisting of 8-14 subunits, including two large subunits and several ..
  7. ncbi Tailed bacteriophages: the order caudovirales
    H W Ackermann
    Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada
    Adv Virus Res 51:135-201. 1998
    ..share a series of high-level taxonomic properties and show many facultative features that are unique or rare in viruses, for example, tail appendages and unusual bases...
  8. pmc Present and future arboviral threats
    Scott C Weaver
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Antiviral Res 85:328-45. 2010
    Arthropod-borne viruses (arboviruses) are important causes of human disease nearly worldwide...
  9. ncbi Infections and autoimmune diseases
    Jean Francois Bach
    Laboratoire d Immunologie, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Autoimmun 25:74-80. 2005
    ..B4 virus in type I diabetes and the encephalomyocarditis virus in autoimmune myositis, two models in which viruses are thought to act by increasing immunogenicity of autoantigens secondary to local inflammation...
  10. pmc Influenza virus morphogenesis and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Virus Res 143:147-61. 2009
    Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to Orthomyxoviridae family...
  11. ncbi Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology
    Abraham Karpas
    Department of Haematology, University of Cambridge Clinical School, MRC Centre, Hills Road, Cambridge CB2 2QH, UK
    Biol Rev Camb Philos Soc 79:911-33. 2004
    ..has had a profound impact by unveiling an unusual form of viral replication: the multiplication of RNA viruses via a proviral DNA, for which Jan Svoboda provided the experimental model over forty years ago...
  12. pmc Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs
    Don B Gammon
    Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton AB T6G 2H7, Canada
    J Virol 82:12520-34. 2008
    ..the intentional genetic modification of viral sequences by bioterrorists or the selection of drug resistance viruses during the course of antiviral therapy...
  13. pmc Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses
    S C Weaver
    Department of Pathology, University of Texas Medical Branch, Galveston 77555, USA
    J Virol 71:613-23. 1997
    ..shown previously to have arisen by recombination between eastern equine encephalomyelitis (EEE)- and Sindbis-like viruses (C. S. Hahn, S. Lustig, E. G. Strauss, and J. H. Strauss, Proc. Natl. Acad. Sci. USA 85:5997-6001, 1988)...
  14. ncbi Avian influenza A viruses in birds --an ecological, ornithological and virological view
    E F Kaleta
    Klinik fur Vogel, Reptilien, Amphibien und Fische, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen
    Dtsch Tierarztl Wochenschr 112:448-56. 2005
    Avian influenza A viruses (AIV) are the causative agents of the presently most important poultry disease...
  15. ncbi [Swine influenza virus: evolution mechanism and epidemic characterization--a review]
    Xian Qi
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
    Wei Sheng Wu Xue Bao 49:1138-45. 2009
    ..pigs contain both SA alpha 2,6 Gal and SA alpha 2,3 Gal receptors and can be infected with swine, human and avian viruses, therefore, pigs have been considered as an intermediate host for the adaptation of avian influenza viruses to ..
  16. ncbi Epidemiology of hemorrhagic fever viruses
    J W LeDuc
    Disease Assessment Division, U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701 5001
    Rev Infect Dis 11:S730-5. 1989
    Twelve distinct viruses associated with hemorrhagic fever in humans are classified among four families: Arenaviridae, which includes Lassa, Junin, and Machupo viruses; Bunyaviridae, which includes Rift Valley fever, Crimean-Congo ..
  17. ncbi Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses
    J Shirai
    Department of Exotic Diseases, National Institute of Animal Health, Kodaira, Tokyo, Japan
    J Vet Med Sci 62:85-92. 2000
    ..triiodide), and quaternary ammonium compound (didecyldimethylammonium chloride), on several exotic disease viruses were examined...
  18. ncbi Foodborne viruses: an emerging problem
    Marion Koopmans
    National Institute of Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan, 9, NL 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 90:23-41. 2004
    Several groups of viruses may infect persons after ingestion and then are shed via stool...
  19. ncbi [Viral gastroenteritis in children]
    Helena Ambrozová
    Department of Infectious Diseases 2nd, Medicine Faculty, Charles University of Prague, Czech Republic
    Klin Mikrobiol Infekc Lek 11:83-91. 2005
    PURPOSE OF THE TRIAL: To establish the involvement of viruses in the aetiology of diarrhoeal disorders in children, the incidence of individual viruses in various age groups and in different seasons, the impact of the aetiological agent ..
  20. ncbi Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model
    Lijuan Yuan
    Epidemiology Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Vet Immunol Immunopathol 87:147-60. 2002
    Enteric viruses are a major cause of diarrhea in animals and humans. Among them, rotaviruses are one of the most important causes of diarrhea in young animals and human infants...
  21. pmc The herpes simplex virus type 1 glycoprotein D (gD) cytoplasmic terminus and full-length gE are not essential and do not function in a redundant manner for cytoplasmic virion envelopment and egress
    Hyun Cheol Lee
    Department of Pathobiological Sciences, Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803 USA
    J Virol 83:6115-24. 2009
    ..Furthermore, two additional recombinant viruses were constructed by mutating from ATG to CTG the initiation codons of gE (gEctg) or both gE and gM (gEctg+gMctg), ..
  22. ncbi Parasitic crustaceans as vectors of viruses, with an emphasis on three penaeid viruses
    Robin M Overstreet
    Department of Coastal Sciences, The University of Southern Mississippi, Ocean Springs, MS 39564, USA
    Integr Comp Biol 49:127-41. 2009
    Parasitic crustaceans serve as both hosts and vectors of viruses as well as of parasites and other microbial pathogenic agents. Few of the presumably numerous associations are known, but many can be anticipated...
  23. ncbi Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems
    A M Burroughs
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Genome Dyn 3:48-65. 2007
    We present an overview of comparative genomics of ATP-dependent DNA packaging systems of viruses. Several distinct ATPase motors and accessory proteins have been identified in DNA-packaging systems of viruses such as terminase-portal ..
  24. pmc In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate
    Malachy Ifeanyi Okeke
    Department of Microbiology and Virology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Virol J 6:55. 2009 and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics...
  25. ncbi Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Med Virol 78:408-16. 2006
    ..suspected respiratory viral infection, and 26 asymptomatic patients were investigated for presence of respiratory viruses either in 56 nasopharyngeal aspirate or 72 bronchoalveolar lavage samples taken at different times after ..
  26. ncbi Viruses as an etiology of obesity
    Richard L Atkinson
    Obetech Obesity Research Center, 800 E Leigh St, Suite 50, Richmond, VA 23219, USA
    Mayo Clin Proc 82:1192-8. 2007
    ..This rapid spread is compatible with an infectious origin. This review discusses the 5 animal viruses and 3 human viruses that have been shown to cause obesity and examines the evidence to date for virus-induced ..
  27. pmc Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses
    O T Gorman
    Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318
    J Virol 65:3704-14. 1991
    ..and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses. H1N1 human and classical swine viruses (i.e...
  28. pmc Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections
    L K Selin
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
    J Exp Med 183:2489-99. 1996
    Experimental analyses of the acute cytotoxic T lymphocyte (CTL) response to viruses have focused on studying these infections in immunologically naive hosts...
  29. pmc Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 46:1329-35. 2002
    ..HPMPC])-resistant forms of camelpox, cowpox, monkeypox, and vaccinia viruses were developed by prolonged passage in Vero 76 cells in the presence of drug...
  30. ncbi Animal models of papillomavirus pathogenesis
    M Saveria Campo
    Department of Veterinary Pathology, Institute of Comparative Medicine, Glasgow University, UK
    Virus Res 89:249-61. 2002
    ..Despite the evidence obtained in animals, the role of viruses in human cancer was dismissed as irrelevant...
  31. pmc Exploring the diversity of plant DNA viruses and their satellites using vector-enabled metagenomics on whiteflies
    Terry Fei Fan Ng
    College of Marine Science, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e19050. 2011
    ..Less is known about viruses that have not caused major diseases in crops, or viruses from native vegetation, which are a reservoir of ..
  32. ncbi Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 94322 5600, USA
    Antiviral Res 57:101-11. 2003
    When considering viruses of potential importance as tools for bioterrorism, several viruses in the Bunya- and Togaviridae families have been cited...
  33. ncbi Insect-transmitted vertebrate viruses: flaviviridae
    G V Ludwig
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702
    In Vitro Cell Dev Biol Anim 29:296-309. 1993
    The Flaviviridae include almost 70 viruses, nearly half of which have been associated with human disease...
  34. ncbi [Antibody titers against measles, rubella, mumps and varicella-zoster viruses in medical students]
    Noriko Yoshida
    Institute of Health and Sports Sciences, Kurume University, Mii machi, Kurume, Japan
    Sangyo Eiseigaku Zasshi 49:21-6. 2007
    ..The antibody titers to measles, rubella, mumps and varicella viruses were measured in 1,139 students(417 men, 722 women, average age 21.3+/-2...
  35. ncbi Hepatitis E virus coinfection with hepatotropic viruses in Egyptian children
    Maysaa El Sayed Zaki
    Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt
    J Microbiol Immunol Infect 41:254-8. 2008
    Major hepatotropic viruses continue to be important causes of acute viral hepatitis in developing countries...
  36. ncbi Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses
    C Giorgi
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Virology 180:738-53. 1991
    The sequences and coding strategies of the S RNAs of two viruses, Toscana (TOS) and the M12 derivative of Rift Valley fever ZH-548 (RVF, Phlebovirus genus, Bunyaviridae) have been determined from cDNA clones and compared to the ..
  37. pmc Diversity and evolution of chromatin proteins encoded by DNA viruses
    Robson F de Souza
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Biochim Biophys Acta 1799:302-18. 2010
    Double-stranded DNA viruses display a great variety of proteins that interact with host chromatin...
  38. ncbi Mapping specific functions in the capsid structure of canine parvovirus and feline panleukopenia virus using infectious plasmid clones
    C R Parrish
    James A Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853
    Virology 183:195-205. 1991
    ..Those plasmids were transfected into permissive cells and viruses recovered were shown to contain intact genomes, having regenerated the complete viral 5' ends up to 100 m.u...
  39. ncbi Tropical Whitefly IPM Project
    Francisco J Morales
    Tropical Whitefly IPM Project, International Centre for Tropical Agriculture, CIAT, Apartado Aereo 6713, Cali, Colombia
    Adv Virus Res 69:249-311. 2007
    ..the New Zealand Agency for International Development (NZAID), to manage whitefly pests and whitefly-transmitted viruses in the Tropics...
  40. ncbi Pathogenesis of ruminant herpesvirus infections
    M Engels
    Institute of Virology, Faculty of Veterinary Medicine, University of Zurich, Switzerland
    Vet Microbiol 53:3-15. 1996
    ..The associated diseases reflect the biological nature of the causative viruses. Clinically, the symptoms may be mild and localized or include severe generalized disease, leading eventually to ..
  41. ncbi Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus
    Justin D Brown
    Southeastern Cooperative Wildlife Disease Study, Department of Population Health, Wildlife Health Building, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    J Wildl Dis 43:660-7. 2007
    Since 2002, H5N1 highly pathogenic avian influenza (HPAI) viruses have caused mortality in numerous species of wild birds; this is atypical for avian influenza virus (AIV) infections in these avian species, especially for species within ..
  42. ncbi Perspectives in studies of human tumor viruses
    George Klein
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Front Biosci 7:d268-74. 2002
    Tumor viruses can be found in both the RNA and DNA virus kingdoms. All RNA tumor viruses belong to the retrovirus family...
  43. ncbi The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors
    Chao Tan Guo
    Institute of Bioengineering, Zhejiang Academy of Medical Sciences, 182 Tianmushan Road, Hangzhou 310016, China
    Glycobiology 17:713-24. 2007
    The receptor specificity of influenza viruses is one factor that allows avian influenza viruses to cross the species barrier...
  44. ncbi Mismatched hemagglutinin and neuraminidase specificities in recent human H3N2 influenza viruses
    Upma Gulati
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Virology 339:12-20. 2005
    The hemagglutinin (HA) of influenza viruses initiates infection by binding to sialic acid on the cell surface via alpha2,6 (human) or alpha2,3 (avian) linkage...
  45. pmc RNA viruses in hymenopteran pollinators: evidence of inter-Taxa virus transmission via pollen and potential impact on non-Apis hymenopteran species
    Rajwinder Singh
    Department of Entomology, The Pennsylvania State University, Pennsylvania, United States of America
    PLoS ONE 5:e14357. 2010
    ..Among honey bee pathogens, RNA viruses are emerging as a serious threat and are suspected as major contributors to CCD...
  46. doi Virus inactivation by salt (NaCl) and phosphate supplemented salt in a 3D collagen matrix model for natural sausage casings
    Tinka Wieringa-Jelsma
    Central Veterinary Institute of Wageningen UR, P O Box 65, NL 8200 AB Lelystad, The Netherlands
    Int J Food Microbiol 148:128-34. 2011
    Due to possible presence and spread of contagious animal viruses via natural sausage casings the international trade in these food products is subject to veterinary and public health requirements...
  47. ncbi Rapid and sensitive detection of respiratory virus infections for directed antiviral treatment using R-Mix cultures
    Kirsten St George
    Clinical Virology Laboratory, University of Pittsburgh Medical Center, A 912, Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Clin Virol 24:107-15. 2002
    ..We therefore investigated a new rapid culture system (R-Mix) that contains a mixture of two cell lines and detects respiratory viruses within 24 h.
  48. ncbi Methods for engineering resistance to plant viruses
    Mysore R Sudarshana
    Western Institute for Food Safety and Security, University of California, Davis, USA
    Methods Mol Biol 354:183-95. 2007
    The development of genetically engineered resistance to plant viruses is a result of efforts to understand the plant-virus interactions involved in "crossprotection," a phenomenon observed with several plant virus diseases...
  49. ncbi Oncogenes of DNA and RNA tumor viruses and the origin of cellular oncogenes
    G Vecchio
    Universita degli Studi di Napoli Federico II, Dipartimento di Biologia e Patologia, Naples, Italy
    Hist Philos Life Sci 15:59-74. 1993
    Oncogenes were first described as the genes of DNA tumor viruses responsible for in vivo and in vitro neoplastic transformation induced by such viruses...
  50. ncbi Influenza activity in China: 1998-1999
    Guo Yuanji
    Institute of Virology, Chinese Academy of Preventive Medicine, 100 Ying Xin Jie, Xuan Wu Qu, Beijing, PR China
    Vaccine 20:S28-35. 2002
    During 1989-1999, influenza A H3N2 and H1N1 subtypes and B type viruses were still co-circulating in human population in China, while influenza A (H3N2) virus was predominant strain...
  51. ncbi An overview of the epidemiology of avian influenza
    Dennis J Alexander
    Virology Department, VLA Weybridge, Addlestone, Surrey, UK
    Vaccine 25:5637-44. 2007
    Only viruses of the Influenzavirus A genus have been isolated from birds and termed avian influenza [AI] viruses, but viruses with all 16 haemagglutinin [H1-H16] and all 9 neuraminidase [N1-N9] influenza A subtypes in the majority of ..
  52. ncbi Presence of specific viruses in the middle ear fluids and respiratory secretions of young children with acute otitis media
    Johanna Nokso-Koivisto
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    J Med Virol 72:241-8. 2004
    The purpose of the study was to investigate the presence of different viruses in middle ear fluids and nasopharyngeal aspirates in young children with acute otitis media...
  53. doi Tissue and host tropism of influenza viruses: importance of quantitative analysis
    Hong Zhang
    Z BioMed, Inc, Rockville, MD, 20855, USA
    Sci China C Life Sci 52:1101-10. 2009
    It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/glycolipids containing sialic acids in alpha2,6-linkage; while avian and equine influenza viruses preferentially bind to those ..
  54. pmc Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?
    Tom Reichert
    Entropy Research Institute, 345 S, Great Road, Lincoln, Massachusetts 01773, USA
    BMC Infect Dis 10:5. 2010
    ..e., novel H1N1 may be antigenically similar to H1N1 viruses that circulated at an earlier time...
  55. ncbi Exogenous porcine viruses
    P S Paul
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, NE 68588, USA
    Curr Top Microbiol Immunol 278:125-83. 2003
    ..Limited information is available on the public health risk of many exogenous swine viruses, and reliable and rapid diagnostic tests are available for only a few of these...
  56. pmc Phylogenetic analysis of members of the Phycodnaviridae virus family, using amplified fragments of the major capsid protein gene
    J B Larsen
    Institute of Biology, University of Bergen, Jahnebakken 5, N 5020 Bergen, Norway
    Appl Environ Microbiol 74:3048-57. 2008
    Algal viruses are considered ecologically important by affecting host population dynamics and nutrient flow in aquatic food webs. Members of the family Phycodnaviridae are also interesting due to their extraordinary genome size...
  57. ncbi Surveillance activities and molecular analysis of H5N1 highly pathogenic avian influenza viruses from Thailand, 2004-2005
    Chantanee Buranathai
    Department of Livestock Development, 69 1 Payathai Road, Rajathevi, Bangkok 10400, Thailand
    Avian Dis 51:194-200. 2007
    Avian influenza (AI) outbreaks were first reported in Thailand in January 2004. In the past 2 yr, AI viruses have caused three epidemic waves. Disease prevention and control in all aspects have been actively carried out...
  58. ncbi Generation of an attenuated H5N1 avian influenza virus vaccine with all eight genes from avian viruses
    Huoying Shi
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, 225009 Yangzhou, Jiangsu, People s Republic of China
    Vaccine 25:7379-84. 2007
    ..outbreaks in poultry and the potential pandemic threat to humans caused by the highly pathogenic avian influenza viruses (HPAIVs) of H5N1 subtype, improvement in biosecurity and the use of inactivated vaccines are two main options for ..
  59. ncbi [Examination of biocides for their effectiveness against animal viruses according to European Union Standards with emphasis on the selection of a suitable test virus]
    Ahmad Al-Khleif
    Institut für Hygiene und Infektionskrankheiten der Tiere, Justus Liebig Universitat Giessen
    Berl Munch Tierarztl Wochenschr 122:58-62. 2009
    ..Considered viral species included different non-enveloped viruses [bovine enterovirus type 1 (ECBO (Enteric Cytopathogenic Bovine Orphan) virus), mammalian reovirus type 1, feline ..
  60. doi Comparative analysis of the mosaic genomes of tailed archaeal viruses and proviruses suggests common themes for virion architecture and assembly with tailed viruses of bacteria
    Mart Krupovic
    Department of Biological and Environmental Sciences and Institute of Biotechnology, Viikki Biocenter 2, PO Box 56 Viikinkaari 5, University of Helsinki, FIN 00014 Helsinki, Finland
    J Mol Biol 397:144-60. 2010
    Tailed double-stranded DNA viruses (order Caudovirales) represent the dominant morphotype among viruses infecting bacteria...
  61. pmc Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution
    Sjouke G M Van Poucke
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Virol J 7:38. 2010
    ..pigs have been considered the most likely "mixing vessel" for reassortment between human and avian influenza viruses (AIVs)...
  62. pmc Parvovirus replication
    K I Berns
    Department of Microbiology, Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021
    Microbiol Rev 54:316-29. 1990
    The members of the family Parvoviridae are among the smallest of the DNA viruses, with a linear single-stranded genome of about 5 kilobases...
  63. pmc Evolving gene therapy approaches for osteosarcoma using viral vectors: review
    M A Witlox
    Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Bone 40:797-812. 2007
    ..on the 5 leading viral vectors used in cancer gene therapy, specifically retroviruses, adeno-associated viruses, herpes viruses and lentiviruses with the most detailed analysis reserved for adenoviruses...
  64. ncbi Antigenic and genetic analyses of H1N1 influenza A viruses from European pigs
    I H Brown
    Central Veterinary Laboratory Weybridge, Addlestone, Surrey, UK
    J Gen Virol 78:553-62. 1997
    H1N1 influenza A viruses isolated from pigs in Europe since 1981 were examined both antigenically and genetically and compared with H1N1 viruses from other sources...
  65. ncbi Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice
    Midori Ogawara
    Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Japan
    J Neurosci Res 69:353-61. 2002
    ..These recombinant viruses differentially conferred PIMT-I or PIMT-II expressions in cultured neurons...
  66. ncbi Genetic diversity of ruminant pestiviruses from Spain
    A Hurtado
    Instituto Vasco de Investigacion y Desarrollo Agrario NEIKER, Berreaga, 1, 48160 Derio, Bizkaia, Spain
    Virus Res 92:67-73. 2003
    ..When compared with strains from GenBank database, Spanish viruses clustered into three genotypes: BVDV 1, BDV and CSFV. No BVDV 2 strains were identified...
  67. ncbi Viral versus cellular BCL-2 proteins
    J M Hardwick
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Cell Death Differ 10:S68-76. 2003
    All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2. Gamma herpesviruses are associated with human and animal lymphoid and epithelial tumours...
  68. ncbi Identification of contaminating adenovirus type 1 in the ATCC reference strain of respiratory syncytial virus A2 (VR-1302)
    Rachel Cameron
    Department of Virology, Biota Holdings Limited, Level 4, 616 St Kilda Road, Melbourne 3004, Vic, Australia
    Virus Res 92:151-6. 2003
    ..Since RSV A2 is used worldwide as a representative virus of RSV type A viruses, and because the ATCC is often cited as the source of the parent stock, we considered it important to bring these ..
  69. ncbi Prevalence of hepatitis A, B, C and E virus in adolescents with type-1 diabetes mellitus
    Mehmet Emre Atabek
    Department of Pediatrics, Selcuk University, School of Medicine, Konya, Turkey
    Int J Adolesc Med Health 15:133-7. 2003
    ..In this study, we aimed to determine the prevalence of hepatitis A, B, C and E viruses in type-1 diabetes mellitus.
  70. ncbi New bioinformatics tools for viral genome analyses at Viral Bioinformatics--Canada
    David J Esteban
    University of Victoria, Department of Biochemistry and Microbiology, Victoria, BC V8W 3P6, Canada
    Pharmacogenomics 6:271-80. 2005
    b>Viruses are much smaller than prokaryotes and eukaryotes, and it is now practical to sequence closely related members of virus families, strains, or even different isolates recovered during the course of an outbreak...
  71. ncbi [The influence of professional degree on the knowledge of HIV, HBV and HCV infections in dentistry practice]
    F Vitale
    Dipartimento di Igiene e Microbiologia Sezione Igiene, Universita degli Studi di Palermo
    Ann Ig 17:185-96. 2005
    ..Overall, most of the participants showed a good knowledge of the transmission pattern of blood-borne viruses as well as good practice for personal hygiene (washing of hands, routine use of gloves, etc.). However 80...
  72. pmc Design of a small-molecule entry inhibitor with activity against primary measles virus strains
    Richard K Plemper
    Department of Microbiology and Immunology, 3086 Rollins Research Center, 1510 Clifton Road, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 49:3755-61. 2005
    ..6 to 3.0 microM, depending on the MV genotype) against a panel of wild-type MV strains representative of viruses that are currently endemic in the field.
  73. pmc eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?
    Christopher J Carter
    Schizophr Bull 33:1343-53. 2007
    ..In cells, related stressors (starvation, viruses, cytokines, oxidative, and endoplasmic reticulum stress) activate a series of eIF2-alpha kinases, which arrest ..
  74. pmc Identification of a contemporary human parechovirus type 1 by VIDISCA and characterisation of its full genome
    Luciano Kleber de Souza Luna
    Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Virol J 5:26. 2008
    Enteritis is caused by a spectrum of viruses that is most likely not fully characterised. When testing stool samples by cell culture, virus isolates are sometimes obtained which cannot be typed by current methods...
  75. doi Vaccines for leishmaniasis in the fore coming 25 years
    Clarisa B Palatnik-de-Sousa
    Instituto de Microbiologia Prof Paulo de Goes, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, PO Box 68040 CEP 21941 590 Rio de Janeiro, Brazil
    Vaccine 26:1709-24. 2008
    ..Second-generation vaccines using live genetically modified parasites, or bacteria or viruses containing Leishmania genes, recombinant or native fractions are known since the 1990s...
  76. doi Development of a Taqman RT-PCR assay for the detection and quantification of negatively stranded RNA of human enteroviruses: evidence for false-priming and improvement by tagged RT-PCR
    Mael Bessaud
    Unité postulante de biologie des virus entériques, Institut Pasteur, 25 rue du Dr Roux, 75 015 Paris, France
    J Virol Methods 153:182-9. 2008
    Human enteroviruses are among the most common viruses infecting humans. These viruses are known to be able to infect a wide range of tissues and are believed to establish persistent infections...
  77. doi Effects of changing land use on the microbial water quality of tidal creeks
    Guy T Didonato
    NOAA Hollings Marine Laboratory, Charleston, SC 29412, USA
    Mar Pollut Bull 58:97-106. 2009
    ..A seasonal pattern was observed for indicator bacteria but not for indicator viruses. Coliphage typing indicated the likely source of contamination was nonhuman...
  78. ncbi Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently
    Sophie Duraffour
    Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Antivir Ther 13:977-90. 2008
    ..anti-orthopoxviral molecule targeting the F13L protein of vaccinia virus, which is involved in the wrapping of viruses. The discrepancy in sensitivities of several orthopoxviruses to ST-246 has raised questions about potential ..
  79. pmc Worldwide distribution of HIV type 1 epitopes recognized by human anti-V3 monoclonal antibodies
    Timothy Cardozo
    New York University School of Medicine, Departments of Pharmacology, Pathology and Environmental Medicine, New York, New York 10016, USA
    AIDS Res Hum Retroviruses 25:441-50. 2009
    ..Searching the HIV database for the occurrence of each epitope motif in worldwide viruses and correcting the results based on published WHO epidemiology reveal that the 447-52D epitope we defined occurs ..
  80. ncbi Myelopeptide-5 abolishes virus-induced immunosuppression by restoring T cell functions
    R G Belyovskaya
    The Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 147:59-62. 2009
    ..and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4(+) lymphocyte (its target cell) was studied using [(3)H]MP-5 (dissociation ..
  81. doi Viruses and bacteria in karst and fractured rock aquifers in East Tennessee, USA
    Trisha B Johnson
    Clancy Environmental Consultants, Inc, Saint Albans, VT 05478, USA
    Ground Water 49:98-110. 2011
    A survey of enteric viruses and indicator bacteria was carried out in eight community water supply sources (four wells and four springs) in East Tennessee...
  82. doi Prevalence of human T-cell lymphotropic virus (HTLV-1/2) in individuals from public health centers in Mozambique
    Adele Caterino-de-Araujo
    Immunology Department, Adolfo Lutz Institute, Secretary of Health of São Paulo, Sao Paulo, S P, Brazil
    AIDS Res Hum Retroviruses 26:559-61. 2010
    The prevalence of human T-cell lymphotropic viruses types 1 and 2 (HTLV-1/2) in Mozambique is not known...
  83. pmc A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif
    Norio Matsushima
    Sapporo Medical University Center for Medical Education, Sapporo, Hokkaido 060 8556, Japan
    BMC Microbiol 10:235. 2010
    Leucine rich repeats (LRRs) are present in over 60,000 proteins that have been identified in viruses, bacteria, archae, and eukaryotes. All known structures of repeated LRRs adopt an arc shape. Most LRRs are 20-30 residues long...
  84. pmc Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system
    Nuria Montserrat
    Center of Regenerative Medicine of Barcelona, Doctor Aiguader 88, P7, 08003 Barcelona, Spain
    J Biol Chem 286:12417-28. 2011
    ..production of retroviral or lentiviral particles together with a high risk of working with potentially harmful viruses overexpressing potent oncogenes, such as c-Myc...
  85. doi Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity
    Kamaljit Singh
    Organic Synthesis Laboratory, Department of Applied Chemical Sciences and Technology, Guru Nanak Dev University, Amritsar 143005, India
    Eur J Med Chem 46:2290-4. 2011
    ..While the compounds were found to possess structure dependent cytostatic activity, these were not found to be efficient inhibitors of M. tuberculosis nor did they inhibit a broad variety of DNA or RNA viruses in cell culture.
  86. pmc Direct inhibition of tombusvirus plus-strand RNA synthesis by a dominant negative mutant of a host metabolic enzyme, glyceraldehyde-3-phosphate dehydrogenase, in yeast and plants
    Tyng Shyan Huang
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    J Virol 85:9090-102. 2011
    The replication of plus-strand RNA viruses depends on many cellular factors...
  87. pmc Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008
    Philip M Armstrong
    Center for Vector Biology and Zoonotic Diseases, The Connecticut Agricultural Experiment Station, New Haven, CT 06504, USA
    Virology 417:203-10. 2011
    ..b>Viruses sampled from Connecticut segregated into a number of well-supported subclades by year of isolation with few ..
  88. doi Time-dependent rates of molecular evolution
    Simon Y W Ho
    Centre for Macroevolution and Macroecology, Evolution Ecology and Genetics, Research School of Biology, Australian National University, Canberra, ACT, Australia
    Mol Ecol 20:3087-101. 2011
    ..We provide a summary of the evidence for time-dependent rates in animals, bacteria and viruses. We review the various biological and methodological factors that can cause rates to be time dependent, including ..
  89. doi Viruses and metabolism: alterations of glucose and glutamine metabolism mediated by human cytomegalovirus
    Yongjun Yu
    Department of Cancer Biology, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Adv Virus Res 80:49-67. 2011
    ..Better understanding of HCMV's effects on cell signaling and metabolism will show how HCMV-mediated modifications of cellular processes relate to pathogenesis and will suggest novel avenues for antiviral therapy...
  90. pmc Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
    Javier A Cappuccio
    Department of Special Pathology, Faculty of Veterinary Sciences, La Plata National University, CC296, A1900 VW, La Plata, Argentina
    J Gen Virol 92:2871-8. 2011
    ..from experimentally inoculated animals cross-reacted mainly with non-contemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted ..
  91. doi Detection of very virulent infectious bursal disease virus from a field outbreak in Central India
    Azad Singh
    MPPCVV Animal Biotechnology Centre, Jabalpur, India
    Acta Vet Hung 60:165-74. 2012
    ..The comparative analysis indicated that these viruses were genetically close to the vvIBDVs previously detected in India...
  92. doi The genome-linked protein VPg of plant viruses-a protein with many partners
    Jun Jiang
    Institut National de la Recherche Scientifique, Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Quebec, Canada H7V 1B7
    Curr Opin Virol 1:347-54. 2011
    For some plant positive-sense RNA viruses, a protein known as VPg (short for virus protein, genome linked) is covalently linked to the 5' end of the viral RNA...
  93. pmc A hybrid EM and Monte Carlo EM algorithm and its application to analysis of transmission of infectious diseases
    Yang Yang
    Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA
    Biometrics 68:1238-49. 2012
    ..We use the hybrid EM-MCEM algorithm to analyze two influenza epidemics in the late 1970s to assess the effects of age and preseason antibody levels on the transmissibility and pathogenicity of the viruses.
  94. pmc Identification of RNA-protein interaction networks involved in the norovirus life cycle
    Surender Vashist
    Calicivirus Research Group, Section of Virology, Department of Medicine, Imperial College London, London, United Kingdom
    J Virol 86:11977-90. 2012
    ..understanding of their molecular mechanisms of genome translation and replication lags behind that for many RNA viruses. Due to the nonculturable nature of human noroviruses, many related members of the Caliciviridae family of small ..
  95. doi Improved virus removal in ceramic depth filters modified with MgO
    Benjamin Michen
    Laboratory for High Performance Ceramics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH 8600 Duebendorf, Switzerland
    Environ Sci Technol 47:1526-33. 2013
    ..However, these microfilters show no sufficient barrier for viruses having diameters down to 20 nm...
  96. doi Severity and outcome associated with human coronavirus OC43 infections among children
    Andréanne Jean
    McGill University Health Centre, Montreal, Quebec, Canada
    Pediatr Infect Dis J 32:325-9. 2013
    ..Subtype OC43 (HCoV-OC43) is the more prevalent human coronavirus in several parts of the world. Recent studies have suggested these viruses can cause severe lower respiratory tract illnesses in children.
  97. pmc Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development
    Tatyana M Timiryasova
    Global Clinical Immunology Department, Sanofi Pasteur, Swiftwater, PA 18370, USA
    Am J Trop Med Hyg 88:962-70. 2013
    ..Production and characterization of dengue challenge viruses used in the assay was standardized...
  98. doi Importance of rabies virus nucleoprotein in viral evasion of interferon response in the brain
    Tatsunori Masatani
    United Graduate School of Veterinary Sciences, Laboratory of Zoonotic Diseases, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Microbiol Immunol 57:511-7. 2013 positions 273 and 394 in the N protein, which are known as pathogenic determinants, affect the ability of the viruses to suppress IFN response in the brain...
  99. doi Effect of temperature and sunlight on the stability of human adenoviruses and MS2 as fecal contaminants on fresh produce surfaces
    Anna Carratala
    Department of Microbiology, Faculty of Biology, University of Barcelona, Av Diagonal 643, 08028 Barcelona, Spain
    Int J Food Microbiol 164:128-34. 2013
    ..This work provides useful information to be considered for improving food safety regarding the transmission of foodborne viruses through supply chains.
  100. pmc The role of bacterial chaperones in the circulative transmission of plant viruses by insect vectors
    Adi Kliot
    Department of Entomology, The Volcani Center, Bet Dagan 50250, Israel
    Viruses 5:1516-35. 2013
    Persistent circulative transmission of plant viruses involves complex interactions between the transmitted virus and its insect vector...
  101. doi Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking
    Julie Blaising
    IBCP, UMR 5086, CNRS, University of Lyon, Lyon, France
    Antiviral Res 100:215-9. 2013
    Arbidol (ARB) is a broad-spectrum antiviral displaying activity against a number of enveloped and non-enveloped viruses. It was described as a viral entry inhibitor and shown to interact at the molecular level with lipid membranes and ..

Research Grants126 found, 100 shown here

  1. Robert M Krug; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Influenza A and B viruses cause a highly contagious respiratory disease in humans...
  2. A novel assay for inhibitors of influenza A virus polymerase complex assembly
    Feng Li; Fiscal Year: 2009
    ..been recently demonstrated by developing a peptide-based inhibitor which potently inhibits growth of influenza A viruses through specifically blocking the PB1-PA interaction and subsequently interfering with viral RNA polymerase ..
  3. Bioavailable proteasome inhibitors as broad-spectrum antivirals
    ..provided by applicant): The ubiquitin proteasome pathway (UPP) is implicated in the lifecycle of multiple viruses. The UPP regulates a wide array of protein function and cellular processes and many viruses are known to ..
  4. The roles of acidic autophagosomes in production of infectious poliovirus
    William T Jackson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): All positive strand RNA viruses studied to date rearranged cellular membranes to promote their own replication...
  5. Coronavirus RNA Replication
    DAVID ALVIN BRIAN; Fiscal Year: 2012
    ..and (ii) subgenomic RNA synthesis (template switching), and (b) characterize suppressor mutations in revertant viruses in order to identify and then prove putative mechanistic interactions in vivo...
  6. Philip J Santangelo; Fiscal Year: 2014
    ..In addition, due to the mutation rate of RNA viruses, it is essential to identify conserved virus specific mechanisms, involving only viral components, which are ..
  7. Hantavirus RNA Encapsidation and Packaging
    Antonito T Panganiban; Fiscal Year: 2012
    ..of the hantavirus genus the entire Bunyaviridae family, and other medically important segmented minus strand RNA viruses such as influenza...
  8. CAROLINA B LOPEZ; Fiscal Year: 2016
    ..Notably, unlike closely related viruses, defective viral genomes can induce the complete activation of DCs independently of complementation by type I IFN ..
  9. Adolfo Garcia-Sastre; Fiscal Year: 2016
    ..pathogenesis which will a) allow us to identify biomarkers for predicting pathogenic potential of new influenza viruses, b) give us the ability to predict which populations may be more susceptible to disease based on genetic ..
  10. Mechanism of inhibition of +RNA virus replication by cyclophilins
    Peter Nagy; Fiscal Year: 2012
    ..applicant): Host factors are key determinants of RNA virus pathology, host - virus interactions, and evolution of viruses. Recent genome-wide screens with several viruses have identified several host proteins, which directly inhibit +..
  11. Viral Protein Determinants of Coronavirus Replication Fidelity
    Everett Clinton Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coronaviruses (CoVs) are a family of positive-stranded RNA viruses that cause respiratory disease in humans ranging in severity from the common cold to severe acute respiratory syndrome (SARS)...
  12. MARY KOLB ESTES; Fiscal Year: 2016
    DESCRIPTION OF PROGRAM PROJECT (provided by applicant): Caliciviruses consist of a family of viruses that infect humans and animals...
  13. Novel vaccine to CMV based on a disc virus
    Alistair McGregor; Fiscal Year: 2010
    ..The mutant viruses will be capable of infecting non-complementing cells in an abortive single cycle of virus replication but ..
  14. MEGAN LOUISE SHAW; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Since they were first identified 30-40 years ago, the filoviruses (Ebola viruses and Marburg viruses) have caused a number of outbreaks of severe hemorrhagic disease in humans that are characterized ..
  15. Roles of Host Kinases in Paramyxovirus RNA Synthesis
    Biao He; Fiscal Year: 2010
    ..include many important human and animal pathogens such as measles virus, mumps virus, human parainfluenza viruses and respiratory syncytial virus (RSV) as well as emerging viruses such as Nipah virus and Hendra virus...
  16. Jianming Qiu; Fiscal Year: 2016
    ..Among DNA viruses, B19V has a unique feature in the processing of its precursor mRNA (pre-mRNA) in that all the viral mRNAs are ..
  17. The influenza A virus nucleoprotein: structure and function
    Yizhi Jane Tao; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Influenza viruses cause highly contagious, acute respiratory illnesses and pose a serious threat to the human public health...
  18. Sean Pj Whelan; Fiscal Year: 2015
    ..provided by applicant): This is an application to renew a grant to study RNA synthesis in minus-strand RNA viruses. Nonsegmented negative-strand (NNS) RNA viruses include some of the most significant human pathogens that are a ..
  19. Encapsidation of the poxvirus genome
    Paula Traktman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Poxviruses, such as vaccinia virus, are unique among DNA viruses in replicating solely within the cytoplasm of the infected cell...
  20. Derek Dube; Fiscal Year: 2014
    ..Despite their magnitude and potential importance, very little is actually known about the manner in which these viruses carried out their infection and replication cycles...
  21. Regulation of DNA Metabolism During Herpes Simplex Virus-1 Infection
    KEVIN FRANCIS BRYANT; Fiscal Year: 2010
    ..including the association between ICP8 and hSNF2H, by mapping these associations in vitro and constructing mutant viruses defective for interactions with the chromatin-remodeling protein of interest...
  22. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..On the other hand, other viruses such as influenza and varicella predispose to exaggerated immune responses that prime the host for severe septic-..
  23. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    Research into mechanisms utilized by viruses to evade cellular antiviral responses is receiving increased attention...
  24. 3C Protease Polyubiquitylation as a Picornavirus Replication Success Determinant
    THOMAS GLEN LAWSON; Fiscal Year: 2012
    ..diseases in humans is caused by infections with picornaviruses, but the mechanisms by which these viruses are replicated in their hosts are far from understood...
  25. Robert A Lamb; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Influenza A and B viruses have tremendous socioeconomic consequences, for influenza continues to occur in regular epidemics and occasional pandemics and is a leading cause of morbidity and mortality...
  26. Persistent hepatitis C virus replication and T cell immunity in pregnancy
    Christopher M Walker; Fiscal Year: 2011
    ..also provide information on the relationship between replicative fitness and patterns of escape mutation in viruses that emerge late in pregnancy and are potentially transmissible to HLA semi-matched infants...
  27. Christopher F Basler; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Ebola viruses (EBOVs) are NIAID category A priority pathogens that cause severe viral hemorrhagic fever...
  28. The Molecular Basis of VEEV Pathogenesis
    ILYA V FROLOV; Fiscal Year: 2012
    ..human and animal pathogens, including Venezuelan (VEEV), eastern (EEEV) and western equine encephalitis (WEEV) viruses. The latter constitute a serious public health threat in the US, because they continuously circulate in nature ..
  29. The Structure and Function of the Influenza Virus Genome
    Robert A Lamb; Fiscal Year: 2011
    Influenza A and B viruses have tremendous socioeconomic consequences, for influenza continues to occur in regular epidemics and occasional pandemics and is a leading cause of morbidity and mortality...
  30. Matthew D Weitzman; Fiscal Year: 2016
    Project Summary Viruses elicit multifaceted responses from the cells that they infect. Among the antiviral defenses of the host cell is activation of a DNA damage response...
  31. Biogenesis and operation of the human cytomegalovirus assembly complex
    Philip E Pellett; Fiscal Year: 2012
    ..We will employ recombinant viruses to express candidate viral and cellular regulatory proteins that have been engineered to contain protein ..
  32. John W Wills; Fiscal Year: 2016 UL16, a poorly understood tegument protein of herpes simplex virus that is conserved among all the herpes viruses (alpha, beta, and gamma)...
  33. Novel role of 1918 influenza virus neuraminidase in hemagglutnin activation
    DONNA TSCHERNE; Fiscal Year: 2010
    ..within HA normally associated with this feature, such as that found in the highly pathogenic H5 and H7 influenza viruses. Previous work suggests that 1918 NA can facilitate the cleavage of HA, pointing to a mechanism of HA cleavage ..
  34. The Mechanisms of IFITM-Mediated Restriction
    I Chueh Huang; Fiscal Year: 2013
    ..transmembrane (IFITM) proteins critical to the interferon-mediated control of several pathogenic viruses, including IAV, dengue virus and West Nile virus...
  35. The Sumoylation System as a Novel Target for Anti-Influenza Therapies
    German Rosas Acosta; Fiscal Year: 2010
    ..processes essential or detrimental for viral replication are significantly less prone to development of resistant viruses. Additionally, by affecting cellular pathways used by the virus, such therapies are more likely to work ..
  36. Multiscale modeling of mechanisms for viral capsid assembly and polymorphism
    Michael F Hagan; Fiscal Year: 2013
    During the replication of many viruses, hundreds to thousands of protein subunits assemble around the viral nucleic acid to form a protein shell called a capsid...
  37. Diane E Griffin; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Arthropod-borne (arbo) viruses, most importantly alphaviruses and flaviviruses, cause widespread epidemics of fever, encephalitis and arthritis and pose increasing threats to human populations ..
  38. Xiaowei Zhuang; Fiscal Year: 2014
    ..As parasites that hijack endogenous cellular functions for replication, viruses are also excellent probes for studying cellular processes...
  39. David J Miller; Fiscal Year: 2014
    ..provided by applicant): Neurotropic alphaviruses such as western, eastern, and Venezuelan equine encephalitis viruses are transmitted by mosquitoes, cause serious and potentially fatal central nervous system infections in humans, ..
  40. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..All viruses require helicases to separate duplex DNA or RNA, yet helicases remain undeveloped antiviral drug targets...
  41. Mark R Denison; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Emerging human and zoonotic RNA viruses including SARS-CoV cause significant global morbidity, mortality, and social disruption...
  42. Efficacy of the antiviral state versus Sindbis and Venezuelan equine encephalitis
    William B Klimstra; Fiscal Year: 2013
    ..if activated in the absence of virus antagonism, is very effective at blocking the replication of multiple viruses, either preventing or substantially reducing disease in animal models...
  43. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..I expect this approach will improve current HSV-2 therapy and can be extended to multiple STD combinations, including elusive viruses such as HIV.
  44. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
    Abstract Human coronaviruses are a diverse group of four antigenically distinct viruses that are important human pathogens that cause upper and lower respiratory tract infections...
  45. WYATT ALLEN MILLER; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): All viruses depend on the host's translation (protein synthesis) machinery...
  46. Functional role of a host metabolic enzyme in viral replication
    Peter Nagy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Plus-stranded (+)RNA viruses infect all kind of species and cause many serious diseases in humans, animals and plants, leading to major losses in food production and representing significant risk to ..
  47. Richard K Plemper; Fiscal Year: 2016
    ..myxovirus families have been chosen for this program because myxoviruses such as influenza virus, parainfluenza viruses, respiratory syncytial virus and measles virus are a major threat to human health, and many fundamentals of ..
  48. Pamela J Skinner; Fiscal Year: 2016
    ..lentivirus infection than other CD4+ T cells through in vitro experimental infections with GFP reporter viruses. In aim 2, we will determine the distribution and phenotype of productively infected T cells in vivo in both ..
  49. ??PK mediated melanoma stem cell oncolysis through non-redundant programmed cell
    ARIC G COLUNGA; Fiscal Year: 2011
    ..Oncolytic viruses are a promising new therapeutic that has the potential to target CSC...
  50. Mark R Denison; Fiscal Year: 2014
    ..Like other plus-strand RNA viruses, coronaviruses replicate in the host cell cytoplasm in association with modified cellular membranes...
  51. Identification of compounds that activate interferon to treat viral infections
    Luis Martinez-Sobrido; Fiscal Year: 2011
    ..However, new antiviral drugs are particularly needed for highly pathogenic viruses for which no vaccine is available or for virus strains resistant to viral inhibitors...
  52. Mammalian Reovirus Post-transcriptional Gene Regulation
    CHARLES ROY MARTINEZ; Fiscal Year: 2010
    ..relationships in ribonucleoprotein (RNP) complexes that mediate post-transcriptional gene regulation in viruses with double-strandedA (dsRNA) genomes...
  53. Combinations of FDA-Approved Host-Targeted Drugs with Broad Antiviral Activity
    JACK THANH NGUYEN; Fiscal Year: 2013
    ..In the cases of rapidly mutating viruses such as HIV, hepatitis C, and influenza, resistance to antivirals can occur rapidly as the result of treatment ..
  54. Regulation of West Nile virus replication.
    Margo A Brinton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Viruses alter cellular pathways to create an environment conducive for their replication cycles as well as to inactivate or escape cellular antiviral responses...
  55. RNA-dependent RNA Synthesis by the Hepatitis C Virus
    CHENG C KAO; Fiscal Year: 2012
    ..However, the replication of all viruses with plus-strand RNA genomes is poorly understood, especially at the biochemical level...
  56. Host-targeted antivirals for influenza and other respiratory virus infections
    MEGAN LOUISE SHAW; Fiscal Year: 2013
    ..virus infections through the discovery of antiviral compounds with broad-spectrum activities against respiratory viruses. The advantages to such drugs are: 1) Eliminating the need to correctly diagnose the cause of the virus infection ..
  57. Preparation and Characterization of 2nd Generation HIV-1 Maturation Inhibitor Dru
    Carl Wild; Fiscal Year: 2013
    ..This novel mechanism of action allows MIs to retain full activity against viruses that have developed resistance to approved classes of HIV drugs...
  58. The Role of Proteasomes in Viral RNA Translation
    Evgeny V Pilipenko; Fiscal Year: 2010
    ..This is of particular importance for those viruses whose mRNA translation is mediated by an Internal Ribosome Entry Segment (IRES), such as Hepatitis C virus (HCV) ..
  59. Agonists of the RIG-I Innate Immune Pathway
    SHAWN PATRICK IADONATO; Fiscal Year: 2013
    ..with drug-like properties that activate innate immune response pathways and inhibit the replication of RNA viruses such as hepatitis C virus (HCV), influenza virus (FLU), and West Nile virus (WNV)...
  60. Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry
    Leor Weinberger; Fiscal Year: 2009
    ..Current treatment approaches are unlikely to halt epidemic spread of many viruses, notably HIV-1, due to prohibitive costs of treatment (i.e...
  61. Sergei V Kotenko; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): There is a growing concern that naturally existing benign viruses within human population or viruses normally residing in non-human hosts may evolve to efficiently infect and spread through the human ..
  62. Constraints on the evolution of influenza oseltamivir resistance
    Jesse D Bloom; Fiscal Year: 2012
    ..This specific proposal deals with the evolution of oseltamivir (Tamiflu) resistance in H1N1 influenza viruses via the His274->Tyr (H274Y) mutation to the neuraminidase protein...
  63. Colin R Parrish; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Emerging viruses are a pressing biomedical problem, with the potential to cause significant morbidity and mortality...
  64. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..Project 4 will analyze the mechanisms underlying the selection of immunodominant epitopes from large DMA viruses, including poxviruses and herpesviruses (HHV-6)...
  65. Mechanisms of non-neutralizing antibody-mediated protection from influenza virus
    DENISE KAMINSKI; Fiscal Year: 2009
    ..are highly variable among influenza strains, neutralizing antibodies are primarily effective against the same viruses used in the vaccine...
  66. Developing a Paramyxovirus-based H5N1 Vaccine
    Biao He; Fiscal Year: 2012
    ..Testing mutant PIV5 viruses as vaccine vectors...
  67. MICHAEL A O'REILLY; Fiscal Year: 2016
    ..a novel subpopulation of alveolar epithelial Type II cells that selectively expresses genes that destroy RNA viruses and bacteria, and control asymmetric cell division of stem/progenitor cells...
  68. William F Degrado; Fiscal Year: 2016
    ..Only a handful of mutations are tolerated at these sites in transmissible viruses. Here, hypothesis-directed and structure-based approaches are used to design new inhibitors of this set of ..
  69. Polymicrobial interactions in the lung.
    ..aeruginosa and respiratory viruses synergize to cause lung disease. My short-term research goal is to elucidate the mechanism whereby P...
  70. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    ..This project seeks to develop a point-of-care test that identifies a panel of bacteria and viruses, including drug-resistant strain of flu, from a single patient sample...
  71. Peptide inhbitors of influenza entry-FAST TRACK
    Russell B Wilson; Fiscal Year: 2011
    ..blocks infection by different strains of influenza A virus of the H1, H3 and H5 subtypes as well as influenza B viruses (IC50 in the nanomolar to picomolar range depending on assay conditions)...
  72. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..Fourth, our publication indicated that the level of T3 controls viral replication and the release of infectious viruses in vitro...
  73. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..There are also a number of emerging viruses such as West Nile and the breaking Mexican swine flu, and a number of potential bioterrorism pathogens such as ..
  74. Polymicrobial Interactions in the Lung
    ..aeruginosa and respiratory viruses synergize to cause lung disease. My short-term research goal is to elucidate the mechanism whereby P...
  75. Gender Factors Influencing Susceptability to Influenza
    Sabra L Klein; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): During a typical influenza season, influenza A viruses primarily cause mortality in the very young and old;conversely, pandemic influenza viruses, including the 1918 H1N1 subtype and avian H5N1 ..
  76. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..These species also transmit several viruses that cause human diseases...
  77. Glycan receptors specific for canine influenza infection
    Xiu Feng Wan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Influenza A viruses are responsible for large losses of human lives around the world and continue to present a great challenge to both domestic and global public health...
  78. Strain Specific Detection of Influenza at the Point-of-Care
    HYONGSOK TOM SOH; Fiscal Year: 2012
    ..PROJECT SUMMARY Influenza viruses cause significant morbidity and mortality worldwide;World Health Organization (WHO) estimates 250,000 ~ 500,000 ..
  79. Ellis L Reinherz; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Current vaccination strategies against influenza A viruses are primarily based upon elicitation of neutralizing antibodies directed at virion surface expressed hemagglutinin (HA) and neuraminidase (..
  80. Yoshihiro Kawaoka; Fiscal Year: 2016
    ..seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve this goal, cells and mice will be infected with wild-type and mutant influenza A, Ebola, and West ..
  81. Balaji Manicassamy; Fiscal Year: 2014
    ..Hence, influenza viruses are a threat not only humans but also to domestic poultry and wildlife, and viral outbreaks can have a major ..
  82. Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic Potential
    Deborah M Brown; Fiscal Year: 2013
    ..monitor the development of CD4 CTL memory responses and their ability to promote heterosubtypic immunity by using viruses that differ in outer coat proteins in CD8 deficient mice or using viruses that lack dominant CD8 epitopes...
  83. Betty L Slagle; Fiscal Year: 2014
    ..In summary, viruses are adept at targeting cellular pathways that benefit viral replication...
  84. I Chueh Huang; Fiscal Year: 2016
    ..We demonstrated that, uniquely among known viral restriction factors, IFITM proteins restricted viruses before they entered cells...
  85. Center of Excellence for Influenza Research and Surveillance
    Richard Webby; Fiscal Year: 2013
    ..on virologic, epidemiologic, and disease surveillance with emphasis on the rapid characterization of influenza viruses with pandemic potential...
  86. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..for booster doses of either hepatitis A or hepatitis B vaccines can result in both safety from exposure to these viruses and healthcare cost savings...
  87. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes viruses are significant human pathogens causing a wide range of clinical diseases ranging from relatively benign reactivated infections such as cold sores to more deadly cancers...
  88. Susan R Weiss; Fiscal Year: 2016
    ..IFN) response in restricting virus replication and spread in the CNS, and in addition, the mechanisms used by viruses to antagonize the IFN response...
    ..Rickettsial group of organisms (Scrub typhus, Spotted fever group, Ehrlichia, Anaplasma etc.) and Viruses ( KFD, Dengue, Japanese Encephalitis, West Nile Virus, Chikungunya virus, Tick borne Encephalitis virus, Crimean ..
  90. Aubree L Gordon; Fiscal Year: 2016
    ..A virus will be evaluated over time and space, including an investigation of intra-host diversity, using viruses obtained from both the cohort study and the household transmission study...
  91. Margaret Kielian; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Alphaviruses and flaviviruses are small enveloped plus-sense RNA viruses with structurally and functionally-related membrane fusion proteins...
  92. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Influenza A viruses exhibit extreme diversity via multiple serotypes of the hemagglutinin (HA 1-16) and neuraminidase (NA 1-9) surface antigens...
  93. Construct novel influenza A (H1N1) virus chimeric HA genes for development of bro
    VICTOR CHESTER HUBER; Fiscal Year: 2010
    ..There are concerns that the virus may reassort with seasonal human influenza viruses giving rise to either increased transmissibility or pathogenicity...
  94. Thirteenth Annual Meeting of the Rocky Mountain Virology Association
    Joel Rovnak; Fiscal Year: 2013
    ..topics discussed include medical virology (vaccines, epidemiology, viral zoonoses), arthropod-borne diseases (RNA viruses and RNA metabolism, viral vectors and vector biology), host defenses (viral immunology and pathogenesis), ..
  95. Ralph S Baric; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Viruses encode novel subsets of uncharacterized genes (predicted and hypothetical ORFs and noncoding RNAs) which can be expressed to modulate virus replication efficiency and/or host antiviral ..
  96. Xiang Jin Meng; Fiscal Year: 2016
    ..findings that host S17 and S19 gene sequences were inserted into the HVR of HEV that resulted in recombinant viruses with expanded cell tropism of different animal origins lends further credence to our hypothesis...
  97. Ronald C Desrosiers; Fiscal Year: 2016
    ..and influenza A virus;this threonine residue was shown to be the efficient target of O-glycosylation on all three viruses. In all three cases, this O-glycosylated threonine was essential for the infectivity of the virus...


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