Classical swine fever virus

Summary

Alias: Hog cholera virus, classical swine fever virus CSFV, swine fever virus, hog cholera virus HCV, Pestivirus type 2, classical swine fever virus (CSFV) strains, hog cholera virus (HCV) strains

Top Publications

  1. ncbi Marker vaccine strategies and candidate CSFV marker vaccines
    Xiao Nan Dong
    Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of the Ministry of Education, Beijing 100084, PR China
    Vaccine 25:205-30. 2007
  2. ncbi The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3
    Julian Seago
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 88:3002-6. 2007
  3. doi The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3
    Julian Seago
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 91:721-6. 2010
  4. pmc Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro
    Nicolas Ruggli
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    J Virol 83:817-29. 2009
  5. doi Identification of a conserved linear B-cell epitope at the N-terminus of the E2 glycoprotein of Classical swine fever virus by phage-displayed random peptide library
    Wu Ping Peng
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, Heilongjiang, China
    Virus Res 135:267-72. 2008
  6. doi The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor
    Virginie Doceul
    BBSRC Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 89:1881-9. 2008
  7. ncbi Establishment and characterisation of two cDNA-derived strains of classical swine fever virus, one highly virulent and one avirulent
    Daniel Mayer
    Institute of Virology and Immunoprophylaxis, CH 3147 Mittelhäusern, Switzerland
    Virus Res 98:105-16. 2003
  8. pmc N-linked glycosylation status of classical swine fever virus strain Brescia E2 glycoprotein influences virulence in swine
    G R Risatti
    Plum Island Animal Disease Center, ARS, USDA, PO Box 848, Greenport, NY 11944 0848, USA
    J Virol 81:924-33. 2007
  9. pmc Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B
    Tomokazu Tamura
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Virol 86:8602-13. 2012
  10. pmc Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7
    Ana R Fiebach
    Institute of Virology and Immunoprophylaxis IVI, Mittelhausern, Switzerland
    J Virol 85:8002-11. 2011

Research Grants

  1. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
  2. W M BUJALOWSKI; Fiscal Year: 2016
  3. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
  4. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
  5. XIV International Poxvirus/Iridovirus Workshop
    EDWARD NILES; Fiscal Year: 2002
  6. Structure-Function Relationship of DNA Polymerases
    Ming Daw Tsai; Fiscal Year: 2006
  7. Mechanism of ribosomal subunit joining in eukaryotes
    Tatyana Pestova; Fiscal Year: 2005

Patents

  1. Combined Vaccines for Prevention of Porcine Virus Infections
  2. METHOD FOR SPECIFIC DETECTION OF CLASSICAL SWINE FEVER VIRUS
  3. COMBINED VACCINES FOR PREVENTION OF PORCINE VIRUS INFECTIONS
  4. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
  5. Hog cholera virus vaccine and diagnostic
  6. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
  7. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
  8. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
  9. Method of Detection of Classical Swine Fever
  10. Edible swine cholera vaccine using plant transformant and method for preparing the same

Detail Information

Publications266 found, 100 shown here

  1. ncbi Marker vaccine strategies and candidate CSFV marker vaccines
    Xiao Nan Dong
    Laboratory of Immunology, Department of Biology, Tsinghua University, Protein Science Laboratory of the Ministry of Education, Beijing 100084, PR China
    Vaccine 25:205-30. 2007
    Classical swine fever (CSF) is an economically important highly contagious disease of swine worldwide. Classical swine fever virus (CSFV) is its etiological agent, and the only natural hosts are domestic pigs and wild boars...
  2. ncbi The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3
    Julian Seago
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 88:3002-6. 2007
    b>Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the family Flaviviridae. The N(pro) product of CSFV targets the host's innate immune response and can prevent the production of type I interferon (IFN)...
  3. doi The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3
    Julian Seago
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 91:721-6. 2010
    Classical swine fever is a notifiable disease of pigs. The causative agent, classical swine fever virus (CSFV), is highly contagious and causes mild to severe haemorrhagic disease depending on the virulence of the strain...
  4. pmc Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro
    Nicolas Ruggli
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    J Virol 83:817-29. 2009
    ..We previously showed with classical swine fever virus (CSFV) that deletion of the entire N(pro) gene resulted in attenuation in pigs...
  5. doi Identification of a conserved linear B-cell epitope at the N-terminus of the E2 glycoprotein of Classical swine fever virus by phage-displayed random peptide library
    Wu Ping Peng
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, Heilongjiang, China
    Virus Res 135:267-72. 2008
    The E2 protein of Classical swine fever virus (CSFV) is an important envelope glycoprotein, which is responsible for inducing protective immune response in swine. Four antigenic domains, A-D, have been mapped on the E2 protein...
  6. doi The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor
    Virginie Doceul
    BBSRC Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 89:1881-9. 2008
    b>Classical swine fever virus (CSFV) belongs to the genus Pestivirus and is the causative agent of classical swine fever, a haemorrhagic disease of pigs...
  7. ncbi Establishment and characterisation of two cDNA-derived strains of classical swine fever virus, one highly virulent and one avirulent
    Daniel Mayer
    Institute of Virology and Immunoprophylaxis, CH 3147 Mittelhäusern, Switzerland
    Virus Res 98:105-16. 2003
    The virulence of classical swine fever virus (CSFV) strains including established laboratory strains as well as field isolates ranges from avirulent to highly virulent...
  8. pmc N-linked glycosylation status of classical swine fever virus strain Brescia E2 glycoprotein influences virulence in swine
    G R Risatti
    Plum Island Animal Disease Center, ARS, USDA, PO Box 848, Greenport, NY 11944 0848, USA
    J Virol 81:924-33. 2007
    E2 is one of the three envelope glycoproteins of classical swine fever virus (CSFV)...
  9. pmc Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B
    Tomokazu Tamura
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Virol 86:8602-13. 2012
    b>Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious disease of pigs...
  10. pmc Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7
    Ana R Fiebach
    Institute of Virology and Immunoprophylaxis IVI, Mittelhausern, Switzerland
    J Virol 85:8002-11. 2011
    ..Here, we report that N(pro) of classical swine fever virus (CSFV) interacts also with IRF7, another mediator of type I IFN induction...
  11. doi The classical swine fever virus N-terminal protease N(pro) binds to cellular HAX-1
    Helen L Johns
    Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, UK
    J Gen Virol 91:2677-86. 2010
    The positive-stranded RNA genome of classical swine fever virus (CSFV) encodes 12 known proteins. The first protein to be translated is the N-terminal protease (N(pro))...
  12. ncbi Identification of a novel virulence determinant within the E2 structural glycoprotein of classical swine fever virus
    G R Risatti
    Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA
    Virology 355:94-101. 2006
    b>Classical swine fever virus (CSFV) E2 glycoprotein contains a discrete epitope (TAVSPTTLR, residues 829-837 of CSFV polyprotein) recognized by monoclonal antibody (mAb) WH303, used to differentiate CSFV from related ruminant pestiviruses,..
  13. pmc Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus
    Birke Andrea Tews
    Institut fur Immunologie, Friedrich Loeffler Institut, Paul Ehrlich Str 28, D 72076 Tubingen, Germany
    J Virol 83:4823-34. 2009
    ..E(rns) dimerization-negative mutants of classical swine fever virus were found to be attenuated in pigs even though the virus clearly replicated and induced a significant ..
  14. pmc Classical swine fever virus p7 protein is a viroporin involved in virulence in swine
    Douglas P Gladue
    Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Greenport, New York, USA
    J Virol 86:6778-91. 2012
    The nonstructural protein p7 of classical swine fever virus (CSFV) is a small hydrophobic polypeptide with an apparent molecular mass of 6 to 7 kDa...
  15. doi Classical swine fever virus NS3 enhances RNA-dependent RNA polymerase activity by binding to NS5B
    Ping Wang
    Research Institute for Agricultural Microbiology, College of Life and Environment Sciences, Shanghai Normal University, Shanghai, 200234, China
    Virus Res 148:17-23. 2010
    ..To investigate the effect of NS3 on classical swine fever virus (CSFV) NS5B RNA-dependent RNA polymerase activity (RdRp) activity and NS3-NS5B interaction, RdRp ..
  16. doi Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis
    Qinghai Tang
    College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi, 712100, People s Republic of China
    Virus Genes 42:355-62. 2011
    Classical swine fever (CSF) caused by virulent strains of classical swine fever virus (CSFV) is a hemorrhagic disease of pigs and is characterized by disseminated intravascular coagulation, thrombocytopenia, and immunosuppression...
  17. pmc Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites
    Tomokazu Tamura
    Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Res 45:47. 2014
    ..In conclusion, the present study demonstrates that functional Npro influences the innate immune response at local sites of virus replication in pigs and contributes to pathogenicity of CSFV in synergy with viral replication...
  18. pmc The structure of classical swine fever virus N(pro): a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction
    Keerthi Gottipati
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
    PLoS Pathog 9:e1003704. 2013
    ..The structures thus establish the mechanism of auto-catalysis and subsequent auto-inhibition of trans-activity of N(pro), and its role in subversion of host immune response. ..
  19. doi Identification of antigen-specific residues on E2 glycoprotein of classical swine fever virus
    Chia Yi Chang
    Animal Health Research Institute, Council of Agriculture, 376 Chung Cheng Road, Tansui, Taipei, Taiwan
    Virus Res 152:65-72. 2010
    Envelope glycoprotein E2 of classical swine fever virus (CSFV) is the major antigen that induces neutralizing antibodies in infected pigs...
  20. ncbi Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria
    G Wen
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    Arch Virol 152:1565-73. 2007
    ..Our results provide insight into the structure-function relationship of CSFV NS3 and facilitate our understanding of its role in the replication cycle of CSFV...
  21. doi Classical swine fever virus NS3 is an IRES-binding protein and increases IRES-dependent translation
    Zailing Zhu
    College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China
    Virus Res 153:106-12. 2010
    ..But, CSFV NS5B was not found to interact with the IRES. The inhibitive effect of NS5B on binding of CSFV NS3 to IRES was supposed to result from the NS3-NS5B interaction which has been documented...
  22. doi Influence of NS5A protein of classical swine fever virus (CSFV) on CSFV internal ribosome entry site-dependent translation
    Ming Xiao
    College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, PR China
    J Gen Virol 90:2923-8. 2009
    ..internal ribosome entry site (IRES) present in the 5' untranslated region (UTR) promotes translation of classical swine fever virus (CSFV) genomes...
  23. doi Identification of host cell binding peptide from an overlapping peptide library for inhibition of classical swine fever virus infection
    Xuewu Li
    Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, People s Republic of China
    Virus Genes 43:33-40. 2011
    The envelope proteins of classical swine fever virus (CSFV) mediate the binding of CSFV to cell surface molecules and allow CSFV subsequent to enter host cells...
  24. doi Antigenic mimicking with cysteine-based cyclized peptides reveals a previously unknown antigenic determinant on E2 glycoprotein of classical swine fever virus
    Chia Yi Chang
    Animal Health Research Institute, Council of Agriculture 376 Chung Cheng Road, Tansui, New Taipei City 25158, Taiwan
    Virus Res 163:190-6. 2012
    Envelope glycoprotein E2 of classical swine fever virus (CSFV) is the major antigen that induces neutralizing antibodies in infected pigs...
  25. doi Effects of glycosylation on antigenicity and immunogenicity of classical swine fever virus envelope proteins
    Boris K Gavrilov
    Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA
    Virology 420:135-45. 2011
    b>Classical swine fever virus (CSFV) harbors three envelope glycoproteins (E(rns), E1 and E2)...
  26. pmc Interaction of classical swine fever virus with membrane-associated heparan sulfate: role for virus replication in vivo and virulence
    M M Hulst
    Institute for Animal Science and Health, Research Branch Houtribweg, NL 8200 AB Lelystad, The Netherlands
    J Virol 75:9585-95. 2001
    Passage of native classical swine fever virus (CSFV) in cultured swine kidney cells (SK6 cells) selects virus variants that attach to the surface of cells by interaction with membrane-associated heparan sulfate (HS)...
  27. ncbi Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility
    H M Weingartl
    NCFAD, CFIA, 1015 Arlington St, Winnipeg, MB, Canada R3E 3M4
    J Virol Methods 104:203-16. 2002
    ..three clones supported the replication of vesicular stomatitis virus (VSV), pseudorabies virus (PRV), classical swine fever virus (CSFV), swine vesicular disease virus (SVDV), swine poxvirus, African swine fever virus (ASFV), herpes ..
  28. doi Diagnostic specificity of a real-time RT-PCR in cattle for foot-and-mouth disease and swine for foot-and-mouth disease and classical swine fever based on non-invasive specimen collection
    G T Fosgate
    Departments of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Vet Microbiol 132:158-64. 2008
    Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) are highly contagious and can cause great economic losses when introduced into disease-free regions...
  29. ncbi Classical swine fever (CSF) marker vaccine. Trial I. Challenge studies in weaner pigs
    A Uttenthal
    Danish Veterinary Institute for Virus Research, Lindholm, DK 4771, Kalvehave, Denmark
    Vet Microbiol 83:85-106. 2001
    Two commercial marker vaccines against classical swine fever virus (CSFV) and companion diagnostic tests were examined in 160 conventional pigs...
  30. ncbi Development of a novel hot-start multiplex PCR for simultaneous detection of classical swine fever virus, African swine fever virus, porcine circovirus type 2, porcine reproductive and respiratory syndrome virus and porcine parvovirus
    Monica Giammarioli
    Perugia, 06126, Italy
    Vet Res Commun 32:255-62. 2008
    ..Specific primers for each of five virus genomes, namely classical swine fever virus (CSFV), African swine fever virus (ASFV), porcine circovirus type 2 (PCV2), porcine reproductive and ..
  31. doi Simulating the spread of classical swine fever virus between a hypothetical wild-boar population and domestic pig herds in Denmark
    A Boklund
    Danish Meat Association, Axelborg, Axeltorv 3, DK 1609 Copenhagen V, Denmark
    Prev Vet Med 85:187-206. 2008
    ..Danish pig farmers fear that this would lead to a higher risk of introduction of classical swine fever virus (CSFV), which could have enormous consequences in terms of loss of pork exports...
  32. ncbi Development and evaluation of a novel antigen capture assay for the detection of classical swine fever virus antigens
    A Clavijo
    National Center for Foreign Animal Disease, Winnipeg, Manitoba, Canada
    Vet Microbiol 60:155-68. 1998
    An antigen-capture enzyme immunoassay (EIA) was developed to detect classical swine fever virus (CSFV) antigen directly from 10% w/v tissue suspension...
  33. pmc Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due to a single amino acid change in envelope protein E(rns)
    M M Hulst
    Research Branch Houtribweg, Institute for Animal Science and Health, NL 8200 AB Lelystad, The Netherlands
    J Virol 74:9553-61. 2000
    Infection of cells with Classical swine fever virus (CSFV) is mediated by the interaction of envelope glycoprotein E(rns) and E2 with the cell surface...
  34. doi Simultaneous detection of Classical swine fever virus and North American genotype Porcine reproductive and respiratory syndrome virus using a duplex real-time RT-PCR
    Dan Cheng
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, Heilongjiang, China
    J Virol Methods 151:194-9. 2008
    ..In this study, a duplex real-time RT-PCR for simultaneous detection of Classical swine fever virus (CSFV) and North American (NA) genotype Porcine reproductive and respiratory syndrome virus (PRRSV) ..
  35. ncbi A common neutralizing epitope on envelope glycoprotein E2 of different pestiviruses: implications for improvement of vaccines and diagnostics for classical swine fever (CSF)?
    P A van Rijn
    Central Institute for Animal Disease Control CIDC Lelystad, 8203 AA, Lelystad, The Netherlands
    Vet Microbiol 125:150-6. 2007
    The Pestivirus genus within the family of Flaviviridae consists of at least three species; classical swine fever virus (CSFV) found in swine and wild boar, bovine viral diarrhoea virus type 1 and type 2 (BVDV-I and BVDV-II) mainly ..
  36. pmc Screwworms, Cochliomyia hominivorax, reared for mass release do not carry and spread foot-and-mouth disease virus and classical swine fever virus
    M F Chaudhury
    USDA ARS, Screwworm Research Unit, Panama City, Panama
    J Insect Sci 8:1-5. 2008
    ..Are screwworms capable of harboring and spreading foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) when they are grown in virus-inoculated larval rearing medium? In one experiment, screwworm ..
  37. doi Seroprevalence and risk factors for the presence of ruminant pestiviruses in the Dutch swine population
    W L A Loeffen
    Department of Virology, Central Veterinary Institute of Wageningen UR CVI Lelystad, 8200AB Lelystad, The Netherlands
    Vet Microbiol 136:240-5. 2009
    Swine can be infected with classical swine fever virus (CSFV), as well as ruminant pestiviruses: bovine viral diarrhoea virus (BVDV), and Border disease virus (BDV)...
  38. doi Patterns of gene expression in swine macrophages infected with classical swine fever virus detected by microarray
    Douglas P Gladue
    Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Greenport, NY 11944, United States
    Virus Res 151:10-8. 2010
    Infection of domestic swine with highly virulent, classical swine fever virus (CSFV) strain Brescia, causes lethal disease in all infected animals...
  39. ncbi Mutations in the carboxyl terminal region of E2 glycoprotein of classical swine fever virus are responsible for viral attenuation in swine
    G R Risatti
    Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269 3089, USA
    Virology 364:371-82. 2007
    ..F., Lu, Z., Holinka, L.G., French, R.A., Tulman, E.R., Rock, D.L. 2005a. The E2 glycoprotein of classical swine fever virus is a virulence determinant in swine. J. Virol. 79, 3787-3796] that chimeric virus 319...
  40. pmc Mutations in classical swine fever virus NS4B affect virulence in swine
    I Fernandez-Sainz
    Plum Island Animal Disease Center, USDA ARS NAA, P O Box 848, Greenport, NY 11944 0848, USA
    J Virol 84:1536-49. 2010
    NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine...
  41. ncbi Introduction to classical swine fever: virus, disease and control policy
    V Moennig
    Institute of Virology, School of Veterinary Medicine, Buenteweg 17, D 30559, Hannover, Germany
    Vet Microbiol 73:93-102. 2000
    b>Classical swine fever virus is a spherical enveloped particle of about 40-60 nm in diameter with a single stranded RNA genome of about 12,300 bases with positive polarity, classified as a pestivirus within the family Flaviviridae...
  42. pmc Deletions of structural glycoprotein E2 of classical swine fever virus strain alfort/187 resolve a linear epitope of monoclonal antibody WH303 and the minimal N-terminal domain essential for binding immunoglobulin G antibodies of a pig hyperimmune serum
    M Lin
    Animal Diseases Research Institute, Nepean, Ontario, Canada
    J Virol 74:11619-25. 2000
    The major structural glycoprotein E2 of classical swine fever virus (CSFV) is responsible for eliciting neutralizing antibodies and conferring protective immunity...
  43. doi Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs
    J Tarradas
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la UAB, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 142:51-8. 2010
    Classical swine fever (CSF) is a highly contagious viral infection affecting domestic and wild pigs. For classical swine fever virus (CSFV), immunization with plasmids expressing different versions of glycoprotein E2 has proven an ..
  44. doi Development of a magnetic bead microarray for simultaneous and simple detection of four pestiviruses
    Neil LeBlanc
    Joint R and D Division, Departments of Virology, The National Veterinary Institute SVA and The Swedish University of Agricultural Sciences SLU, SE 751 89, Uppsala, Sweden
    J Virol Methods 155:1-9. 2009
    ..e. classical swine fever virus (CSFV), border disease virus (BDV), bovine viral diarrhoea virus type 1 (BVDV1) and type 2 (BVDV2)...
  45. ncbi Chimeric pestiviruses: candidates for live-attenuated classical swine fever marker vaccines
    Franziska Wehrle
    Institute of Virology and Immunoprophylaxis, CH 3147 Mittelhäusern, Switzerland
    J Gen Virol 88:2247-58. 2007
    The use of attenuated classical swine fever virus (CSFV) strains as live vaccines is no longer allowed for the control of classical swine fever in Europe, due to the inability to differentiate between infected and vaccinated animals (..
  46. pmc Lymphocyte apoptosis during classical swine fever: implication of activation-induced cell death
    A Summerfield
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    J Virol 72:1853-61. 1998
    Infection of pigs with classical swine fever virus (CSFV), a member of the Flaviviridae family, causes a severe leukopenia, particularly notable with the lymphocytes...
  47. doi Enhanced immunity against classical swine fever in pigs induced by prime-boost immunization using an alphavirus replicon-vectored DNA vaccine and a recombinant adenovirus
    Yuan Sun
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, Heilongjiang, China
    Vet Immunol Immunopathol 137:20-7. 2010
    Classical swine fever (CSF) - caused by the classical swine fever virus (CSFV) - is a fatal disease of pigs that is responsible for extensive losses to the swine industry worldwide...
  48. doi Classical swine fever virus in South-Eastern Europe--retrospective analysis of the disease situation and molecular epidemiology
    Sandra Blome
    Friedrich Loeffler Institute, Institute of Diagnostic Virology, Suedufer 10, 17493 Greifswald Isle of Riems, Germany
    Vet Microbiol 146:276-84. 2010
    ..3. They were tentatively named 2.3.1 and 2.3.2...
  49. ncbi Development of a classical swine fever subunit marker vaccine and companion diagnostic test
    R J Moormann
    Institute of Animal Science and Health ID DLO, P O Box 65, NL 8200 AB, Lelystad, Netherlands
    Vet Microbiol 73:209-19. 2000
    ..protected pigs against clinical signs of CSF, following intranasal challenge with 100LD(50) of virulent classical swine fever virus (CSFV) at 2 weeks after vaccination...
  50. pmc Complete genomic sequence of border disease virus, a pestivirus from sheep
    P Becher
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat, D 35392 Giessen, Germany
    J Virol 72:5165-73. 1998
    ..family Flaviviridae comprises three established species, namely, bovine viral diarrhea virus (BVDV), classical swine fever virus (CSFV), and border disease virus from sheep (BDV)...
  51. ncbi Transmission of classical swine fever virus within herds during the 1997-1998 epidemic in The Netherlands
    A Stegeman
    Department of Immunology, Pathobiology and Epidemiology, Institute for Animal Science and Health, Lelystad, The Netherlands
    Prev Vet Med 42:201-18. 1999
    In this paper, we describe the transmission of Classical Swine Fever virus (CSF virus) within herds during the 1997-1998 epidemic in The Netherlands...
  52. ncbi Vaccination against classical swine fever virus: limitations and new strategies
    Irene Greiser-Wilke
    Institute of Virology, EU Reference Laboratory for Classical Swine Fever, School of Veterinary Medicine Hannover, Hannover, Germany
    Anim Health Res Rev 5:223-6. 2004
    ..Although there is an urgent need for more advanced marker vaccines and better discriminatory tests, the development of new DIVA vaccines against CSF is hampered by the small market potential for these products...
  53. ncbi Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
    ..Other viruses such as classical swine fever virus (CSFV), African swine fever virus, pseudorabies virus (PRV), vesicular stomatitis virus, vesicular ..
  54. ncbi Identification of antigenic regions of the Erns protein for pig antibodies elicited during classical swine fever virus infection
    Min Lin
    Animal Diseases Research Institute, Nepean, Ontario, Canada K2H 8P9
    J Biochem 136:795-804. 2004
    The structural glycoprotein E(rns) of classical swine fever virus (CSFV) is one of the major antibody targets upon infection of pigs with the virus...
  55. ncbi Comparison of the complete genomic sequence of the border disease virus, BD31, to other pestiviruses
    J F Ridpath
    National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    Virus Res 50:237-43. 1997
    The genus Pestivirus is composed of hog cholera virus (HCV) [also known as classical swine fever virus (CSFV)], bovine viral diarrhea virus (BVDV), and border disease virus (BDV)...
  56. ncbi Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification
    Paul Becher
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat, Frankfurter Strabetae 107, D 35392, Giessen, Germany
    Virology 311:96-104. 2003
    ..genus Pestivirus comprises the four approved species Bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, Classical swine fever virus (CSFV), and Border disease virus (BDV) and one tentative fifth species represented by a single strain (..
  57. ncbi Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a role in protection
    Llilianne Ganges
    Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, INIA, Madrid, Spain
    Vet J 177:169-77. 2008
    b>Classical swine fever virus (CSFV) is the causative agent of one of the most devastating porcine haemorrhagic viral diseases, classical swine fever (CSF)...
  58. doi In vitro antiviral activity of some uridine derivatives of 2-deoxy sugars against classical swine fever virus
    Ewelina Krol
    Department of Molecular Virology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    Antiviral Res 86:154-62. 2010
    b>Classical swine fever virus glycoproteins: E2, E(rns) (E0) and E1 are detected on the external part of viral particles and play a major role in the initial stages of viral infection...
  59. ncbi Rapid detection and differentiation of wild-type and three attenuated lapinized vaccine strains of classical swine fever virus by reverse transcription polymerase chain reaction
    Chu Hsiang Pan
    Division of Hog Cholera Research, Animal Health Rsearch Institute, Council of Agriculture, Tamsui, Taipei, Taiwan
    J Vet Diagn Invest 20:448-56. 2008
    ..in the viral genome for simultaneous detection and differentiation of wild type and vaccine strains of Classical swine fever virus (CSFV)...
  60. pmc The internal initiation of translation in bovine viral diarrhea virus RNA depends on the presence of an RNA pseudoknot upstream of the initiation codon
    Lorin Moes
    Evolva, CH 4123 Allschwil, Switzerland
    Virol J 4:124. 2007
    ..A pseudoknot structure is characteristic for flavivirus IRESes and in the case of the closely related classical swine fever virus (CSFV) and the more distantly related Hepatitis C virus (HCV) pseudoknot function in translation has ..
  61. doi Efficacy of intradermally administrated E2 subunit vaccines in reducing horizontal transmission of classical swine fever virus
    J C F M Dortmans
    Central Veterinary Institute of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands
    Vaccine 26:1235-42. 2008
    ..and intramuscular (IM) vaccination result in a comparable reduction of horizontal transmission of classical swine fever virus (CSFV), two registered E2 subunit marker vaccines were examined...
  62. ncbi Estimating the probability of freedom of classical swine fever virus of the East-Belgium wild-boar population
    K Mintiens
    Veterinary and Agrochemical Research Centre, Co ordination Centre for Veterinary Diagnostics, Groeselenberg 99, 1180 Brussels, Belgium
    Prev Vet Med 70:211-22. 2005
    ..This represents a big gain of knowledge since we did not use any prior information for the probability of freedom of CSF-virus and took the uncertainty about the accuracy of the diagnostic methods into account...
  63. pmc In planta production of two peptides of the Classical Swine Fever Virus (CSFV) E2 glycoprotein fused to the coat protein of potato virus X
    Gianpiero Marconi
    Dipartimento di Biologia Vegetale e Biotecnologie Agroambientali e Zootecniche, Universita degli Studi di Perugia, Borgo XX Giugno 74, 06121 Perugia, Italy
    BMC Biotechnol 6:29. 2006
    ....
  64. ncbi A serological survey on classical swine fever (CSF), Aujeszky's disease (AD) and porcine reproductive and respiratory syndrome (PRRS) virus infections in French wild boars from 1991 to 1998
    E Albina
    Agence Française de Sécurité Sanitaire et Alimentaire, Unité de Virologie et Immunologie Porcines, Zoopole, Les Croix, Avicole et Porcine, BP 53, F 22440, Ploufragan, France
    Vet Microbiol 77:43-57. 2000
    ..Around 1000-2700 sera a year were tested for the presence of antibodies to classical swine fever virus (CSFV) and also to Aujeszky's disease virus (ADV)...
  65. ncbi Protection of pigs from lethal challenge by a DNA vaccine based on an alphavirus replicon expressing the E2 glycoprotein of classical swine fever virus
    Na Li
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
    J Virol Methods 144:73-8. 2007
    ..Semliki Forest virus (SFV) replicon vectored DNA vaccine (pSFV1CS-E2) expressing the E2 glycoprotein of classical swine fever virus (CSFV) conferred full protection for pigs immunized three times with 600 microg of the vaccine...
  66. ncbi [Applications of reverse genetics in studying classical swine fever virus]
    Dafei Liu
    Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
    Sheng Wu Gong Cheng Xue Bao 25:1441-8. 2009
    Classical swine fever (CSF), caused by classical swine fever virus (CSFV), has been epidemic or endemic in many countries, and causes great economical losses to pig industry worldwide...
  67. ncbi [Co-expression of CSFV T cell epitope E290 peptide and PPV VP2 protein in Lactobacillus casei and determination of specific antibodies in immunized mice]
    Yi Gang Xu
    Department of Veterinary Medicine, Northeast Agriculture University, Harbin 150030, China
    Wei Sheng Wu Xue Bao 47:667-72. 2007
    ..was selected as an antigen delivery vehicle for the development of oral vaccine to express recombinant classical swine fever virus (CSFV) T cell epitope E290 peptide and porcine parvovirus (PPV) VP2 protein...
  68. doi Prime-boost immunization using alphavirus replicon and adenovirus vectored vaccines induces enhanced immune responses against classical swine fever virus in mice
    He ping Zhao
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China
    Vet Immunol Immunopathol 131:158-66. 2009
    ..evaluate the prime-boost vaccination regimens as a novel immunization strategy for DNA vaccine against classical swine fever virus (CSFV)...
  69. ncbi Rescue of infectious classical swine fever and foot-and-mouth disease virus by RNA transfection and virus detection by RT-PCR after extended storage of samples in Trizol
    M A Hofmann
    Institute of Virology and Immunoprophylaxis, Sensematstrasse 293, 3147, Mittelhaeusern, Switzerland
    J Virol Methods 87:29-39. 2000
    A method for storing samples containing classical swine fever virus (CSFV) or foot-and-mouth disease virus (FMDV), respectively, was developed, which abolishes the infectivity of both plus strand RNA viruses, and allows storage of ..
  70. doi Antigenic differentiation of classical swine fever viruses in China by monoclonal antibodies
    Yan Zhu
    Institute of Veterinary Sciences, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, China
    Virus Res 142:169-74. 2009
    The phylogenetic diversity of classical swine fever virus (CSFV) in China has been extensively studied previously, with the report of the classification of Chinese CSFVs into four subgroups within two of the established genotypes, but ..
  71. ncbi Genetic diversity of pestiviruses: identification of novel groups and implications for classification
    P Becher
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat, Giessen, D 35392, Germany
    Virology 262:64-71. 1999
    ..the established species bovine viral diarrhea virus-1 (BVDV-1), BVDV-2, border disease virus (BDV), and classical swine fever virus (CSFV)...
  72. ncbi The effect of sample degradation and RNA stabilization on classical swine fever virus RT-PCR and ELISA methods
    Stuart D Blacksell
    CSIRO Australian Animal Health Laboratory, P O Bag 24, Geelong, Victoria 3200, Australia
    J Virol Methods 118:33-7. 2004
    ..Samples stored in glycerol/saline were negative at RT-PCR at day 3 post-exposure although AC-ELISA was still positive at day 14 post-exposure...
  73. ncbi Numerical taxonomy of the genus Pestivirus based on palindromic nucleotide substitutions in the 5' untranslated region
    Massimo Giangaspero
    Veterinary Microbiology, School of Veterinary Medicine, Faculty of Agriculture, Iwate University, 18 8 Ueda 3 chome, Morioka 020 8550, Iwate, Japan
    J Virol Methods 146:375-88. 2007
    ..have been identified: Bovine viral diarrhea virus 1 (BVDV-1), Bovine viral diarrhea virus 2 (BVDV-2), Classical swine fever virus (CSFV), Border disease virus (BDV), the tentative species Giraffe and a new proposed taxon named ..
  74. doi Assessment of the cell-mediated immunity induced by alphavirus replicon-vectored DNA vaccines against classical swine fever in a mouse model
    He ping Zhao
    Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang, China
    Vet Immunol Immunopathol 129:57-65. 2009
    ..shown that an alphavirus replicon-vectored DNA vaccine (pSFV1CS-E2) encoding the E2 glycoprotein of classical swine fever virus (CSFV) completely protected the immunized pigs from lethal challenge...
  75. doi Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor
    Robert Vrancken
    Veterinary and Agrochemical Research Centre, Groeselenberg 99, B 1180 Ukkel, Belgium
    J Gen Virol 90:1335-42. 2009
    ..of a class of imidazopyridines with potent in vitro antiviral activity against pestiviruses including classical swine fever virus (CSFV)...
  76. ncbi Fibrocytes are potent stimulators of anti-virus cytotoxic T cells
    Carole Balmelli
    Institute of Virology and Immunoprophylaxis, Mittelhausern, Switzerland
    J Leukoc Biol 77:923-33. 2005
    ..Fb were isolated from porcine blood to investigate their ability to stimulate CTL responses using a classical swine fever virus model...
  77. pmc An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages
    P P Powell
    Department of Immunology, BBSRC Institute for Animal Health, Pirbright, Surrey, United Kingdom
    J Virol 70:8527-33. 1996
    ..African swine fever virus (ASFV) is a large, double-stranded DNA virus that infects macrophages...
  78. doi A new subgenotype 2.1d isolates of classical swine fever virus in China, 2014
    Hongliang Zhang
    State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
    Infect Genet Evol 34:94-105. 2015
    ..Given that current vaccines do not appear to provide effective protection against this new subgenotype, further investigation of these strains is urgently needed...
  79. ncbi Transmission of classical swine fever virus by artificial insemination
    A J De Smit
    Institute for Animal Science and Health ID DLO, Department of Mammalian Virology, Lelystad, The Netherlands
    Vet Microbiol 67:239-49. 1999
    ..These results demonstrate that adult boars infected with CSF virus can excrete virus with semen and can, subsequently, transmit the virus to sows and their foetuses via artificial insemination...
  80. doi Dendritic cells--at the front-line of pathogen attack
    Kenneth C McCullough
    Institute of Virology and Immunoprophylaxis, Research Department, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    Vet Immunol Immunopathol 128:7-15. 2009
    ..The present review uses two virus examples--classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2)--to demonstrate the complexity of this host-pathogen ..
  81. ncbi A multiplex DNA suspension microarray for simultaneous detection and differentiation of classical swine fever virus and other pestiviruses
    Dirk Deregt
    Virology Section, Lethbridge Laboratory, Animal Diseases Research Institute, Canadian Food Inspection Agency, Lethbridge, Alta, Canada T1J 3Z4
    J Virol Methods 136:17-23. 2006
    ..Luminex microsphere system) was developed for detection and differentiation of animal pestiviruses: classical swine fever virus (CSFV), bovine viral diarrhea virus types 1 and 2 (BVDV1 and BVDV2), and border disease virus (BDV)...
  82. ncbi Evidence of natural recombination in classical swine fever virus
    Cheng Qiang He
    College of Life Science, Shandong Normal University, Jinan 250014, China
    Virus Res 126:179-85. 2007
    ..Our work revealed that homologous recombination occurred in natural CSFV populations, generating genetic diversity. This would provide some insights for the role homologous recombinant plays in CSFV evolution...
  83. doi Real-time SPR characterization of the interactions between multi-epitope proteins and antibodies against classical swine fever virus
    Hong Tian
    Key Laboratory of Animal Virology of the Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China
    Biochem Biophys Res Commun 431:315-20. 2013
    The envelope glycoprotein E2 is the major immunodominant protein of the classical swine fever virus and can induce neutralizing antibodies and protective host-immune responses in infected swine...
  84. doi Quantitative assessment of the likelihood of the introduction of classical swine fever virus into the Danish swine population
    B M de C Bronsvoort
    University of Edinburgh, Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Prev Vet Med 85:226-40. 2008
    b>Classical swine fever virus (CSFV) is a major infectious-disease agent of livestock and causes production losses through increased morbidity and mortality, particularly of young pigs...
  85. pmc The African swine fever virus nonstructural protein pB602L is required for formation of the icosahedral capsid of the virus particle
    Carolina Epifano
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 80:12260-70. 2006
    African swine fever virus (ASFV) protein pB602L has been described as a molecular chaperone for the correct folding of the major capsid protein p72...
  86. pmc Control of African swine fever virus replication by small interfering RNA targeting the A151R and VP72 genes
    Djénéba Keita
    CIRAD, UMR CMAEE, Montpellier, France
    Antivir Ther 15:727-36. 2010
    African swine fever virus (ASFV) is the unique member of the Asfarviridae family and Asfivirus genus. It is an enveloped double-stranded DNA arbovirus that replicates in the cell cytoplasm, similar to poxviruses...
  87. doi A novel RT-LAMP assay for rapid and simple detection of classical swine fever virus
    Lei Chen
    China Institute of Veterinary Drug Control, Beijing, 100081, China
    Virol Sin 25:59-64. 2010
    A simple and rapid assay for the detection of Classical swine fever virus (CSFV) was established using reverse transcription loop-mediated isothermal amplification (RT-LAMP)...
  88. doi Changes in the porcine peripheral blood mononuclear cell proteome induced by infection with highly virulent classical swine fever virus
    Jinfu Sun
    College of Science, Northeastern University, Shenyang, People s Republic of China
    J Gen Virol 91:2254-62. 2010
    ..of classical swine fever and peripheral blood mononuclear cells (PBMCs) are major targets of classical swine fever virus. To investigate proteomic expression changes in swine PBMCs during lethal CSFV infection, proteins of ..
  89. ncbi Observations on the quasispecies composition of three animal pathogenic RNA viruses
    I Kiss
    Veterinary Institute of Debrecen, Hungary
    Acta Vet Hung 47:471-80. 1999
    ..nature of three animal pathogenic RNA viruses of field origin was examined by testing variants of classical swine fever virus (CSFV) originating from geographically different areas, feline coronavirus (FCoV) detected from the ..
  90. doi Biological characterization of African swine fever virus genotype II strains from north-eastern Estonia in European wild boar
    I Nurmoja
    Estonian Veterinary and Food Laboratory, Tartu, Estonia
    Transbound Emerg Dis . 2017
    ..Following the ongoing epidemic in the Transcaucasian countries and the Russian Federation, African swine fever virus was introduced into the Estonian wild boar population in 2014...
  91. doi Comparison of viraemia- and clinical-based estimates of within- and between-pen transmission of classical swine fever virus from three transmission experiments
    Benoit Durand
    AFSSA LERPAZ, Unité Epidémiologie, 22 rue Pierre Curie, BP 67, F 94703 Maisons Alfort, France
    Vet Microbiol 135:196-204. 2009
    ..This suggests that, in affected herds, the most severely affected animals could play a prominent role in CSFV transmission...
  92. doi Detection of African swine fever virus by loop-mediated isothermal amplification
    Heather E James
    Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol Methods 164:68-74. 2010
    ..and the test was able to detect representative isolates of ASFV (n=38) without cross-reacting with classical swine fever virus. The performance of the LAMP assay was compared with other laboratory tests used for ASF diagnosis...
  93. ncbi Prevention of transplacental transmission of moderate-virulent classical swine fever virus after single or double vaccination with an E2 subunit vaccine
    A J De Smit
    Institute for Animal Science and Health, ID Lelystad, National Reference Laboratory for Classical Swine Fever, The Netherlands
    Vet Q 22:150-3. 2000
    The use of a vaccine against classical swine fever virus (CSFV) during an outbreak of CSF should lead to a reduction in the horizontal or vertical transmission of CSFV. The reduction of vertical, i.e...
  94. pmc African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA
    Modesto Redrejo-Rodríguez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, 28049 Madrid, Spain
    Virology 390:102-9. 2009
    African swine fever virus (ASFV) encodes an AP endonuclease (pE296R) which is essential for virus growth in swine macrophages...
  95. doi A comparative analysis on the synonymous codon usage pattern in viral functional genes and their translational initiation region of ASFV
    Jian Hua Zhou
    State Key Laboratory of Veterinary Etiological Biology, National Foot and mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, People s Republic of China
    Virus Genes 46:271-9. 2013
    The synonymous codon usage pattern of African swine fever virus (ASFV), the similarity degree of the synonymous codon usage between this virus and some organisms and the synonymous codon usage bias for the translation initiation region ..
  96. doi Virulence of classical swine fever virus isolates from Europe and other areas during 1996 until 2007
    G Floegel-Niesmann
    EU Reference Laboratory for CSF, Institute for Virology, University of Veterinary Medicine Hannover, Hannover, Germany
    Vet Microbiol 139:165-9. 2009
    ..Therefore a subclinical course of infection is unlikely, especially in weaner pigs...
  97. doi Tree imbalance causes a bias in phylogenetic estimation of evolutionary timescales using heterochronous sequences
    David Duchene
    Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia
    Mol Ecol Resour 15:785-94. 2015
    ..of tree imbalance on two empirical data sets: mitogenomes from primates and serial samples of the African swine fever virus. In analyses calibrated using dated, heterochronous tips, we found that tree imbalance had a detrimental ..
  98. pmc Autocatalytic cleavage within classical swine fever virus NS3 leads to a functional separation of protease and helicase
    Benjamin Lamp
    Institute of Virology, University of Veterinary Medicine, Vienna, Austria
    J Virol 87:11872-83. 2013
    b>Classical swine fever virus (CSFV) is a positive-stranded RNA virus belonging to the genus Pestivirus within the Flaviviridae family...
  99. doi Early pathogenesis of classical swine fever virus (CSFV) strains in Danish pigs
    Louise Lohse
    National Veterinary Institute, Technical University of Denmark, Lindholm, DK 4771 Kalvehave, Denmark
    Vet Microbiol 159:327-36. 2012
    Host-virus interactions play an important role for the clinical outcome of classical swine fever virus (CSFV) infections in pigs...
  100. doi Assessment of interactions between African swine fever virus, bushpigs (Potamochoerus larvatus), Ornithodoros ticks and domestic pigs in north-western Madagascar
    J Ravaomanana
    FOFIFA, Malagasy Centre for Research in Agronomy, Antananarivo, Madagascar
    Transbound Emerg Dis 58:247-54. 2011
    ..In addition, the presence of antibodies against O. moubata in domestic pigs suggests that soft ticks may be able to maintain ASFV within a domestic pig cycle in areas of Madagascar where they remain present...
  101. doi Application of GP5 protein to develop monoclonal antibody against porcine reproductive and respiratory syndrome virus
    Hong Tian
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
    Virol Sin 26:267-72. 2011
    ..the two cells had specific reactions for the PRRSV and GP5 protein respectively, and no reaction with Classical swine fever virus (CSFV) or Swine vesicular disease virus (SVDV)...

Research Grants7

  1. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..The IRES of classical swine fever virus, a pestivirus, is substantially resistant to inhibition by eIF2 phosphorylation, which can be accounted ..
  2. W M BUJALOWSKI; Fiscal Year: 2016
    ..Mammalian Polymerase ? (pol ?) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA repair ..
  3. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
    ..of the Institute for Animal Health, England, where I studied the intracellular transport of African swine fever virus, a large DNA virus. My work led to the publication of 3 first-author papers. I graduated in September 2004...
  4. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus.
  5. XIV International Poxvirus/Iridovirus Workshop
    EDWARD NILES; Fiscal Year: 2002
    ..Poxviruses are the focus of the majority of the presentations but studies of African Swine Fever Virus, Chlorella Viruses and a variety of iridoviruses are also significant contributions to the meeting...
  6. Structure-Function Relationship of DNA Polymerases
    Ming Daw Tsai; Fiscal Year: 2006
    ..properties will be studied: a high-fidelity enzyme, rat Pol beta, and a low-fidelity enzyme, African Swine Fever virus (ASFV) Pol X...
  7. Mechanism of ribosomal subunit joining in eukaryotes
    Tatyana Pestova; Fiscal Year: 2005
    ....

Patents24

  1. Combined Vaccines for Prevention of Porcine Virus Infections
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  2. METHOD FOR SPECIFIC DETECTION OF CLASSICAL SWINE FEVER VIRUS
    Patent Number: WO2015150083-A1; Date:2015-10-08
  3. COMBINED VACCINES FOR PREVENTION OF PORCINE VIRUS INFECTIONS
    Patent Number: JP2014516041-A; Date:2014-07-07
  4. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
    Patent Number: EP2280069-A1; Date:2011-02-02
  5. Hog cholera virus vaccine and diagnostic
    Patent Number: EP1087014-A1; Date:2001-03-28
  6. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
    Patent Number: JP2010504507-A; Date:2010-02-12
  7. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
    Patent Number: WO2008034622-A2; Date:2008-03-27
  8. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
    Patent Number: EP1905827-A; Date:2008-04-02
  9. Method of Detection of Classical Swine Fever
    Patent Number: JP2008529527-A; Date:2008-08-07
  10. Edible swine cholera vaccine using plant transformant and method for preparing the same
    Patent Number: KR1020100015187-A; Date:2010-02-12
  11. Adjuvation through cross- structure
    Patent Number: WO2007008070-A2; Date:2007-01-18
  12. METHOD FOR SPECIFIC DETECTION OF CLASSICAL SWINE FEVER VIRUS
    Patent Number: WO2011151404-A1; Date:2011-12-08
  13. Method for specific detection of classical swine fever virus
    Patent Number: EP2392680-A1; Date:2011-12-07
  14. Process for producing a marker-vaccine against a mammalian virus
    Patent Number: EP1293573-A2; Date:2003-03-19
  15. Infectious pestivirus pseudo-particles containing functional erns, E1, E2 envelope proteins
    Patent Number: EP1454981-A1; Date:2004-09-08
  16. A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
    Patent Number: JP2013230154-A; Date:2013-11-14
  17. HOG CHOLERA VIRUS VACCINE AND DIAGNOSTIC
    Patent Number: EP0614979-A1; Date:1994-09-14
  18. T CELL STIMULATING PROTEIN OF PESTIVIRUS
    Patent Number: WO9619498-A2; Date:1996-06-27
  19. NUCLEOTIDE SEQUENCES OF PESTIVIRUS STRAINS, POLYPEPTIDES ENCODED BY THESE SEQUENCES AND USE THEREOF FOR DIAGNOSIS AND PREVENTION OF PESTIVIRUS INFECTIONS
    Patent Number: WO9535380-A1; Date:1995-12-28
  20. Hog cholera virus vaccine and diagnostic
    Patent Number: EP0389034-A1; Date:1990-09-26
  21. A live attenuated antigenically marked classical swine fever vaccine
    Patent Number: EP2162151-A1; Date:2010-03-17
  22. Novel vaccine compositions and methods of vaccine preparation for veterinary and human diseases
    Patent Number: WO03013598-A2; Date:2003-02-20
  23. Viral nucleic acid microarray and method of use
    Patent Number: WO2007130519-A2; Date:2007-11-15
  24. Nucleotide sequences of pestivirus strains, polypeptides encoded by these sequences and use thereof for diagnosis and prevention of pestivirus infections
    Patent Number: EP1985705-A2; Date:2008-10-29