Kaposi's sarcoma-associated herpesvirus - Human herpesvirus 8

Summary

Alias: Human herpesvirus 8, Kaposi's sarcoma-associated herpes-like virus, Kaposi's sarcoma-associated herpesvirus, HHV8, KSHV, Kaposi's sarcoma-associated herpesvirus KSHV, Kaposi's sarcoma-associated human herpes virus, Karposi's sarcoma-associated herpes-like virus, Human herpesvirus 8 type P

Top Publications

  1. pmc Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen
    Mel Campbell
    Department of Dermatology, University of California, Davis, California 95616, USA
    J Biol Chem 287:5806-18. 2012
  2. pmc LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex
    Jianhong Hu
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
    PLoS Pathog 10:e1004240. 2014
  3. pmc Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
  4. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis
    Cyprian Rossetto
    Department of Microbiology and Immunology and the Cell and Molecular Biology Graduate Program, University of Nevada Reno, Reno, Nevada 89557, USA
    J Virol 83:8492-501. 2009
  5. pmc Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
    Jianyong Liu
    Johns Hopkins University School of Medicine, Bunting Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231, USA
    J Virol 81:4722-31. 2007
  6. doi Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2
    Laura Marcos-Villar
    Dept Microbiología II, Fac Farmacia, Universidad Complutense de Madrid, Pza Ramon y Cajal, 28040 Madrid, Spain
    J Gen Virol 92:188-94. 2011
  7. pmc Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011
  8. pmc Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
    Ke Lan
    Department of Microbiology and Tumor Virology Program of Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:16287-92. 2007
  9. pmc Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells
    R Subramanian
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    J Virol 84:1704-14. 2010
  10. pmc A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
    R Sun
    Departments of Molecular Biophysics and Biochemistry, Genetics, Pediatrics, and Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:10866-71. 1998

Research Grants

  1. Warren Phipps; Fiscal Year: 2015
  2. EMILY MARIE COUSINS; Fiscal Year: 2014
  3. Erle S Robertson; Fiscal Year: 2016
  4. Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization
    Ronald C Desrosiers; Fiscal Year: 2012
  5. Corey Casper; Fiscal Year: 2014
  6. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
  7. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
  8. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
  9. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
  10. Ren Sun; Fiscal Year: 2016

Patents

  1. BIOMARKERS FOR ENDOMETRIOSIS
  2. Nucleotide carrier for diagnosing and treating oral diseases
  3. Micromirs
  4. Viral nucleic acid microarray and method of use
  5. Analysis of nucleic acids
  6. Highly potent peptides to control cancer and neurodegenerative diseases
  7. Methods, compositions, and devices utilizing microrna to determine physiological conditions
  8. Process for the production of fine chemicals
  9. Serological screening for hhv-8 infection using antigen mixtures
  10. INHIBITORS OF KSHV VIL6 AND HUMAN IL6

Detail Information

Publications222 found, 100 shown here

  1. pmc Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen
    Mel Campbell
    Department of Dermatology, University of California, Davis, California 95616, USA
    J Biol Chem 287:5806-18. 2012
    The Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a multifunctional protein with roles in gene regulation and maintenance of viral latency...
  2. pmc LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex
    Jianhong Hu
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
    PLoS Pathog 10:e1004240. 2014
    Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus associated with KS and two lymphoproliferative diseases...
  3. pmc Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection increases the expression of viral and human interleukin-6 (vIL-6 and hIL-6, respectively), an important factor for cell growth and pathogenesis...
  4. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis
    Cyprian Rossetto
    Department of Microbiology and Immunology and the Cell and Molecular Biology Graduate Program, University of Nevada Reno, Reno, Nevada 89557, USA
    J Virol 83:8492-501. 2009
    The original cotransfection replication assay identified eight human herpesvirus 8 (HHV8)-encoded proteins required for origin-dependent lytic DNA replication...
  5. pmc Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
    Jianyong Liu
    Johns Hopkins University School of Medicine, Bunting Blaustein Building CRB308, 1650 Orleans Street, Baltimore, MD 21231, USA
    J Virol 81:4722-31. 2007
    ..We conclude that LANA inactivates nuclear GSK-3 and modifies the function of proteins that are GSK-3 substrates. In the case of C/EBPs, this translates into LANA-mediated inhibition of differentiation...
  6. doi Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2
    Laura Marcos-Villar
    Dept Microbiología II, Fac Farmacia, Universidad Complutense de Madrid, Pza Ramon y Cajal, 28040 Madrid, Spain
    J Gen Virol 92:188-94. 2011
    The multifunctional Kaposi's sarcoma-associated herpesvirus (KSHV) latent protein latency-associated nuclear antigen 2 (LANA2) has a critical role in KSHV-induced B-cell malignancies...
  7. pmc Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is essential for virus lytic replication...
  8. pmc Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
    Ke Lan
    Department of Microbiology and Tumor Virology Program of Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:16287-92. 2007
    ..This article shows that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) directly interacts with Sel10 and forms a complex in KSHV-infected cells...
  9. pmc Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells
    R Subramanian
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    J Virol 84:1704-14. 2010
    Kaposi's sarcoma-associated herpesvirus (KSHV) viral glycoproteins play important roles in the infectious life cycle and have been implicated in KSHV-associated endothelial cell transformation, angiogenesis, and KS-induced malignancies...
  10. pmc A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
    R Sun
    Departments of Molecular Biophysics and Biochemistry, Genetics, Pediatrics, and Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:10866-71. 1998
    ..Here we identify an immediate-early gene encoded by Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome...
  11. pmc Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies
    Shuhei Sakakibara
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Interferon Cytokine Res 31:791-801. 2011
    Viral interleukin-6 (vIL-6) is a product of Kaposi's sarcoma-associated herpesvirus (KSHV) expressed in latently infected cells and to a higher degree during viral replication...
  12. pmc Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latency
    Horng Shen Chen
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    J Virol 86:9454-64. 2012
    ..cohesins in the control of the switch from latency to the lytic cycle for Kaposi's sarcoma-associated herpesvirus (KSHV)...
  13. ncbi The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex
    Li Liu
    Hamon Center for Therapeutic Oncology Research and Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Biol Chem 277:13745-51. 2002
    The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in immunocompromised individuals...
  14. pmc The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
    Claire Pardieu
    MRC Centre for Medical Molecular Virology, University College London, London, United Kingdom
    PLoS Pathog 6:e1000843. 2010
    ..Here we show that the human herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) is sensitive to tetherin restriction and its activity is counteracted by the KSHV encoded RING-CH E3 ubiquitin ..
  15. pmc The Kaposi's sarcoma-associated herpesvirus K5 E3 ubiquitin ligase modulates targets by multiple molecular mechanisms
    Robert E Means
    Department of Pathology, Yale University School of Medicine, P O Box 208023, New Haven, CT 06520, USA
    J Virol 81:6573-83. 2007
    ..These data indicate that while K5 can act as an E3 ubiquitin ligase to directly mediate cell surface molecule destruction, regulation of its targets occurs through multiple pathways, including ubiquitin-independent mechanisms...
  16. pmc A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia
    Qiliang Cai
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Virol 81:10413-23. 2007
    ..have shown that the latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) targets the HIF-1alpha suppressors von Hippel-Lindau protein and p53 for degradation via its suppressor of ..
  17. pmc Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300
    L Burysek
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 73:7334-42. 1999
    b>Human herpesvirus 8/Kaposi sarcoma-associated virus (HHV-8/KSHV) contains, in addition to genes required for viral replication, a unique set of nonstructural genes which may be part of viral mimicry and contribute to viral replication ..
  18. ncbi HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T IE2, Canada
    Oncogene 20:800-11. 2001
    ..These results illustrate that vIRF-1 is able to block the early stages of the IFN response to virus infection by interfering with the activation of IRF-3 responsive, immediate early IFN genes...
  19. pmc A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
    L Coscoy
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, CA 94143, USA
    J Cell Biol 155:1265-73. 2001
    ..Thus, MIR2 defines a novel class of membrane-bound E3 Ub ligases that modulates the trafficking of host cell membrane proteins...
  20. ncbi Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13
    H Matta
    Department of Medicine, Division of Hematology Oncology and the Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213 1863, USA
    Oncogene 26:1656-60. 2007
    b>Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus, is linked to the development of Kaposi's sarcoma, a disease characterized by the presence of distinctive proliferating spindle-like cells...
  21. pmc EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
    Qi Liang Cai
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    PLoS Pathog 2:e116. 2006
    ..Here we report that the Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) directly functions as a component of the EC5S ubiquitin complex ..
  22. pmc Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding
    Brenna Kelley-Clarke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    J Virol 81:4348-56. 2007
    ..In contrast to the essential role of N-terminal LANA chromosome targeting residues in DNA replication, deficient C-terminal chromosome association did not reduce LANA-mediated DNA replication...
  23. ncbi Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
    D Bubman
    Department of Pathology and Laboratory Medicine, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA
    Oncogene 26:4979-86. 2007
    ..is a rare subtype of non-Hodgkin's lymphoma, which is associated with infection by Kaposi's sarcoma herpesvirus (KSHV)/human herpesvirus-8...
  24. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer
    Wei Bu
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, Newark, NJ 07103, USA
    J Virol 81:5788-806. 2007
    ..We concluded that the proline content, but not the leucine content, of the LR is critical for determining the oligomeric state of Rta...
  25. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export
    Michael Nekorchuk
    UF Shands Cancer Center, University of Florida, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9990-8. 2007
    The ORF57 protein expressed by Kaposi's sarcoma-associated herpesvirus (KSHV) during lytic replication is essential for KSHV virion production. ORF57 enhances gene expression by increasing accumulation of target gene mRNAs...
  26. pmc The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc
    Jianyong Liu
    Viral Oncology Program, Sidney Kimmel Cancer Center, and Department of Pharmacology, Johns Hopkins School of Medicine, Bunting Blaustein Bldg, CRB308, 1650 Orleans St, Baltimore, MD 21231, USA
    J Virol 81:10451-9. 2007
    The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) protein is functionally pleiotropic...
  27. pmc Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein
    Diana Palmeri
    Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Virol 81:13299-314. 2007
    The Kaposi's sarcoma-associated herpesvirus (KSHV) Mta protein, encoded by open reading frame 57, is a transactivator of gene expression that is essential for productive viral replication...
  28. pmc X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency
    Sam J Wilson
    Department of Infection, UCL, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 81:13578-86. 2007
    ..Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with the B-cell neoplasm primary effusion lymphoma (PEL), in which the virus remains latent...
  29. pmc KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor
    Daniel L Di Bartolo
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Blood 111:4731-40. 2008
    ..We show that this pathway is blocked in Kaposi sarcoma herpesvirus (KSHV)-infected primary effusion lymphoma through down-regulation of the TGF-beta type II receptor (TbetaRII) by ..
  30. pmc Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity
    Mair Thomas
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:1656-61. 2008
    ..Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) down-regulates MHC class I molecules to avoid detection by cytotoxic T lymphocytes but renders cells susceptible ..
  31. pmc Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency
    Feng Chun Ye
    Tumor Virology Program, Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 82:4235-49. 2008
    Kaposi's sarcoma-associated herpesvirus (KSHV) latency is central to the evasion of host immune surveillances and induction of KSHV-related malignancies. The mechanism of KSHV latency remains unclear...
  32. pmc Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
    James R Boyne
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    PLoS Pathog 4:e1000194. 2008
    ..In contrast, a number of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic mRNAs lack introns and are exported by the virus-encoded ORF57 protein...
  33. pmc A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activation
    Andreas Konrad
    Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen Nuremberg, Schwabachanlage 10, D 91054 Erlangen, Germany
    J Virol 83:2563-74. 2009
    b>Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma...
  34. pmc Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway
    Faye Gould
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 83:6727-38. 2009
    The Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) protein regulates the latent-lytic switch by transactivating a variety of KSHV lytic and cellular promoters...
  35. pmc Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway
    Hye Ra Lee
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, California 90033, USA
    J Virol 83:6739-47. 2009
    ..Kaposi's sarcoma-associated herpesvirus (KSHV) encodes several viral IFN regulatory factors (vIRF1 to vIRF4) within a cluster of loci, their functions being ..
  36. pmc Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation
    Jie Lu
    Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Virol 83:7129-41. 2009
    ..latency-associated nuclear antigen (LANA), a multifunctional protein of Kaposi's sarcoma-associated herpesvirus (KSHV) that is found in Kaposi's sarcoma tumors, upregulates survivin expression and increases the proliferation of KSHV-..
  37. pmc Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus
    Mandana Mansouri
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Virol 83:9672-81. 2009
    K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and contribute to viral immune evasion by directing the conjugation of ubiquitin to ..
  38. pmc Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression
    Virginie Bottero
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 392:34-51. 2009
    b>KSHV vGPCR, a lytic cycle associated protein, induces several signaling pathways leading to the activation of various transcription factors and consequently the expression of cellular and viral genes...
  39. pmc Involvement of SSRP1 in latent replication of Kaposi's sarcoma-associated herpesvirus
    Jianhong Hu
    Department of Molecular Genetics and Microbiology and UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610 0232, USA
    J Virol 83:11051-63. 2009
    Kaposi's sarcoma-associated herpesvirus (also named human herpesvirus 8) is a gamma-herpesvirus that undergoes both lytic and latent infection...
  40. doi Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus
    Sue Li Dahlroth
    Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS J 276:6636-45. 2009
    ..Mutations specifically affecting host shutoff map to a surface region of the N-terminal domain, implying an essential role in protein-protein interactions, and link the RNase activity of the enzyme to mRNA degradation pathways...
  41. pmc Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus
    Zhiheng He
    Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, The People s Republic of China
    J Virol 84:2047-62. 2010
    ..transcription activator (RTA) encoded by open reading frame 50 (ORF50) of Kaposi's sarcoma-associated herpesvirus (KSHV) is essential and sufficient to initiate lytic reactivation...
  42. pmc Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway
    Fang Lu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 84:2697-706. 2010
    Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cluster of 12 microRNAs (miRNAs) that are processed from a transcript that is embedded within the major latency control region...
  43. pmc Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
    Wuguo Chen
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB no 7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599 7290, USA
    J Virol 84:3898-908. 2010
    ..The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) binds p53. Despite this interaction, we had found that p53 was functional in PEL, i.e...
  44. pmc Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:11297-307. 2010
    Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication...
  45. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways
    Brooke B Sahin
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 6:e1000799. 2010
    ..Here we report that the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds to a unique KSHV polyadenylated nuclear RNA, called PAN RNA, and protects it from degradation ..
  46. pmc Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization
    Eiji Goto
    Laboratory for Infectious Immunity, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 285:35311-9. 2010
    ..This novel ubiquitin chain can function as an internalization signal for MHC I through its association with epsin1, an adaptor molecule containing ubiquitin-interacting motifs...
  47. pmc Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 85:1528-40. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) encodes ORF57, which promotes the accumulation of specific KSHV mRNA targets, including ORF59 mRNA...
  48. pmc miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA
    Xianzhi Lin
    Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 6:e16224. 2011
    Seventeen miRNAs encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) have been identified and their functions have begun to be characterized...
  49. pmc Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice
    Gianna Ballon
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Clin Invest 121:1141-53. 2011
    Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)...
  50. pmc Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression
    Katharina Schmidt
    Virologisches Institut, Universitatsklinikum Erlangen, Schlossgarten 4, D 91054 Erlangen, Germany
    J Virol 85:4530-7. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) carries four genes with homology to human interferon regulatory factors (IRFs)...
  51. pmc The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection
    Jie Lu
    Department of Microbiology and, Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania, School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 85:6148-61. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV; or human herpesvirus 8 [HHV8]) is implicated in the pathogenesis of many human malignancies including Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion ..
  52. pmc A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner
    Hittu Matta
    Jane Ann Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 286:21555-64. 2011
    ..We report that A20 is expressed in Kaposi sarcoma-associated herpesvirus (KSHV)-infected primary effusion lymphoma cell lines, and its expression correlates closely with the expression of KSHV-..
  53. pmc Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells
    Khaled R Alkharsah
    Institut fur Virologie, Hannover Medical School, Hannover, Germany
    J Virol 85:10375-88. 2011
    Kaposi's sarcoma herpesvirus (KSHV) Fas-associated death domain (FADD)-like interleukin-1 beta-converting enzyme (FLICE)-inhibitory protein, vFLIP, has antiapoptotic properties, is a potent activator of the NF-κB pathway, and induces the ..
  54. pmc Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL
    Diana Palmeri
    Department of Microbiology and Molecular Genetics, UMDNJ NJ Medical School, ICPH E350C, 225 Warren St, P O Box 1709, Newark, NJ 07101, USA
    J Virol 85:11901-15. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is the etiologic agent of Kaposi's sarcoma (KS) and lymphoproliferative diseases...
  55. pmc Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity
    Emi Sei
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Virology 419:107-16. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is an essential multifunctional regulator of gene expression...
  56. pmc The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferation
    Jie Lu
    Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 8:e1002479. 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV) is tightly linked to at least two lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD)...
  57. pmc Suppressive regulation of KSHV RTA with O-GlcNAcylation
    Ying Chieh Ko
    National Institute of Cancer Research, National Health Research Institutes, Miaoli County, Taiwan
    J Biomed Sci 19:12. 2012
    The replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV) is a molecular switch that initiates a productive replication of latent KSHV genomes...
  58. pmc Identification of host-chromosome binding sites and candidate gene targets for Kaposi's sarcoma-associated herpesvirus LANA
    Fang Lu
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    J Virol 86:5752-62. 2012
    LANA is essential for tethering the Kaposi's sarcoma-associated herpesvirus (KSHV) genome to metaphase chromosomes and for modulating host-cell gene expression, but the binding sites in the host-chromosome remain unknown...
  59. pmc Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions
    Nitika Paudel
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    J Virol 86:5974-91. 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated with the angioproliferative Kaposi's sarcoma (KS)...
  60. pmc The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA
    Wiebke Jäger
    Institut fur Virologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Virol 86:6745-57. 2012
    Kaposi's sarcoma herpesvirus (KSHV) belongs to the gamma-2 Herpesviridae and is associated with three neoplastic disorders: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD)...
  61. pmc The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation
    Valerie A Morris
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Virology 428:112-20. 2012
    ..In culture, Kaposi's Sarcoma-associated herpesvirus (KSHV) infection of blood endothelial cells drives expression of lymphatic endothelial cell specific markers, in a ..
  62. pmc A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma
    Vasu Punj
    Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 7:e37498. 2012
    Infection with Kaposi's sarcoma associated herpesvirus (KSHV) has been linked to the development of primary effusion lymphoma (PEL), a rare lymphoproliferative disorder that is characterized by loss of expression of most B cell markers ..
  63. pmc Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication
    Da Jiang Li
    Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Virol 86:9866-74. 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is expressed early during lytic KSHV replication, enhances expression of many KSHV genes, and is essential for virus production...
  64. pmc Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIβ for latent DNA replication of the terminal repeats
    Pravinkumar Purushothaman
    Department of Microbiology and Immunology, University of Nevada, Reno, School of Medicine, Center for Molecular Medicine, Reno, Nevada, USA
    J Virol 86:9983-94. 2012
    The latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is critical for the perpetual segregation of viral episomes to the progeny nuclei of ..
  65. pmc Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA
    Maria J Massimelli
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:243-56. 2013
    ..We report that PABPC1 forms a complex with the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein, which allows ORF57 to interact with a 9-nucleotide (nt) core element of KSHV polyadenylated nuclear ..
  66. pmc Phosphorylation of the chromatin binding domain of KSHV LANA
    Crystal Woodard
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Pathog 8:e1002972. 2012
    The Kaposi sarcoma associated herpesvirus (KSHV) latency associated nuclear antigen (LANA) is expressed in all KSHV associated malignancies and is essential for maintenance of KSHV genomes in infected cells...
  67. pmc Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP
    Olga V Hunter
    UT Southwestern Medical Center, Department of Microbiology, Dallas, Texas, USA
    J Virol 87:4005-16. 2013
    The Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 57 (ORF57)-encoded protein (Mta) is a multifunctional regulator of viral gene expression...
  68. pmc H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence
    Hem Chandra Jha
    Department of Microbiology and Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 87:5255-69. 2013
    ..We examined the expression of the DDR genes during Kaposi's sarcoma-associated herpesvirus (KSHV) infection of human peripheral blood mononuclear cells (PBMCs)...
  69. pmc Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A
    Kevin Y Kim
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California, USA
    J Virol 87:6782-93. 2013
    Kaposi's sarcoma-associated herpesvirus (KSHV) latent genomes are tethered to host histones to form a minichromosome also known as an "episome...
  70. doi Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway
    X Zhu
    1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China 2 Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, PR China 3 Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China 4 Department of Laboratory Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, PR China
    Oncogene 33:1986-96. 2014
    Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi's sarcoma (KS), which is the most common AIDS-associated malignancy. KS is characterized by neovascularization and spindle cell proliferation...
  71. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing
    Sophie Schumann
    School of Molecular and Cellular Biology, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Viruses 5:1901-23. 2013
    ..Using the example of ORF57, we will describe cellular bulk mRNA export pathways and highlight their distinct features, before exploring how the virus has evolved to exploit these mechanisms. ..
  72. pmc A unique SUMO-2-interacting motif within LANA is essential for KSHV latency
    Qiliang Cai
    MOE and MOH Key Laboratory of Medical Molecular Virology, School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, People s Republic of China Department of Microbiology and Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States of America
    PLoS Pathog 9:e1003750. 2013
    Kaposi's sarcoma-associated herpesvirus (KSHV) stabilizes hypoxia-inducible factor α (HIF-1α) during latent infection, and HIF-1α reactivates lytic replication under hypoxic stress...
  73. pmc Kaposi's sarcoma-associated herpesvirus-encoded LANA contributes to viral latent replication by activating phosphorylation of survivin
    Jie Lu
    Department of Microbiology and the Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 88:4204-17. 2014
    Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus casually linked to Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL)...
  74. pmc Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation
    Alexandre Mercier
    Novartis Institutes for BioMedical Research, Department of Infectious Diseases, Emeryville, California, USA
    J Virol 88:6762-77. 2014
    ..nuclear antigen (LANA), a multifunctional protein expressed by the Kaposi sarcoma-associated herpesvirus (KSHV) in latently infected cells, is required for stable maintenance of the viral episome...
  75. pmc Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype
    Taeko Kato-Noah
    Department of Microbiology, Cell and Molecular Biology Program, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Virol 81:13519-32. 2007
    Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (HHV8) ORF50 encodes a transactivator, K-Rta, which functions as the switch from latent to lytic virus replication...
  76. pmc Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication
    Ersheng Kuang
    Department of Biological Science, Florida State University, 89 Chieftan Way, Tallahassee, FL 32306 4370, USA
    J Virol 82:1838-50. 2008
    ..We demonstrate that ORF45 of Kaposi's sarcoma-associated herpesvirus (KSHV) interacts with RSK1 and RSK2 and strongly stimulates their kinase activities...
  77. pmc Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene
    Laura Marcos-Villar
    Departamento Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal, 28040 Madrid, Spain
    J Virol 83:8849-58. 2009
    ..Several proteins from Kaposi's sarcoma-associated herpesvirus (KSHV) have been tested as putative POD-disrupting factors with negative results...
  78. pmc The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation
    Roshan Karki
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1001331. 2011
    Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells...
  79. doi Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3
    M Mutocheluh
    School of Cancer Sciences and Cancer Research UK Cancer Centre, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    J Gen Virol 92:2394-8. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4)...
  80. ncbi Tumorigenesis and aberrant signaling in transgenic mice expressing the human herpesvirus-8 K1 gene
    Om Prakash
    Laboratory of Molecular Oncology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Natl Cancer Inst 94:926-35. 2002
    ..To evaluate the potential role of K1 in HHV-8-associated pathogenesis, we produced transgenic mice expressing the HHV-8 K1 gene under the transcriptional control of the simian virus 40 promoter...
  81. ncbi Human herpesvirus 8 virology, epidemiology and related diseases
    H Katano
    Department of Pathology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Jpn J Infect Dis 53:137-55. 2000
    b>Human herpesvirus 8 ([HHV-8], Kaposi's sarcoma-associated herpesvirus [KSHV]) is a novel human oncovirus classified as a gamma-herpesvirus...
  82. pmc Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities
    Nam Hyuk Cho
    Department of Microbiology and Immunology, College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center and Bundang Hospital, Seoul 110 799, Korea
    Exp Mol Med 40:565-73. 2008
    ..K15 open reading frame of Kaposi's sarcoma associated herpesvirus (KSHV), located at the right end of the viral genome, encodes several splicing variants differing in numbers of ..
  83. ncbi Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma
    Elizabeth E Brown
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer 107:2282-90. 2006
    ..sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation...
  84. pmc Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:2. 2005
    Two distinct lineages of rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) have been identified in macaques and other Old World non-human primates...
  85. ncbi Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996
    M Melbye
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen
    Int J Cancer 77:543-8. 1998
    ..We determined risk factors for Kaposi's-sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) seropositivity and incidence of infection over time in a cohort of Danish homosexual men ..
  86. ncbi HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma
    A Antinori
    Department of Infectious Diseases, Catholic University, Roma, Italy
    Brain Pathol 9:199-208. 1999
    ..AIDS-PCNSL) may be associated with infection by human herpesvirus-8/Kaposi's sarcoma associated herpesvirus (HHV-8/KSHV), although at present such association remains controversial...
  87. ncbi Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus
    L Arvanitakis
    Department of Pathology, New York Hospital Cornell Medical Center, New York 10021, USA
    Blood 88:2648-54. 1996
    The recently identified Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been found to be consistently associated with an unusual subset of acquired immunodeficiency syndrome-related ..
  88. ncbi Expression and antigenicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi's sarcoma
    H Katano
    Department of Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Med Virol 59:346-55. 1999
    b>Human herpesvirus 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus, KSHV) is a new herpes virus isolated from patients with AIDS-associated Kaposi's sarcoma (AIDS-KS)...
  89. ncbi Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells
    M Sturzl
    Institute of Molecular Virology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Natl Cancer Inst 91:1725-33. 1999
    b>Human herpesvirus 8 (HHV8) infection is associated with all forms of Kaposi's sarcoma (KS). The HHV8 genome locus ORFK13-72-73 (ORF = open reading frame) encodes proteins that may be important in HHV8-mediated pathogenesis, i.e...
  90. ncbi Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) as a tumour virus
    Gieri Cathomas
    Laboratory of Pathology for Infectious Diseases, Cantonal Institute of Pathology, Liestal, Switzerland
    Herpes 10:72-7. 2003
    Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is present in all clinical variants of Kaposi's sarcoma and two lymphoproliferative diseases: primary effusion lymphoma and multicentric Castleman's disease (..
  91. ncbi The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins
    Mette M Rosenkilde
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Biol Chem 279:32524-33. 2004
    ..from herpesvirus saimiri, ECRF3, is characterized here and compared with that of the well known ORF74 from human herpesvirus 8 (HHV8)...
  92. pmc Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways
    Suraiya Rasheed
    Laboratory of Viral Oncology and Proteomics Research Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032 3626, USA
    J Transl Med 7:75. 2009
    ..While KS is etiologically linked to the human herpesvirus-8 (HHV8) infection, HIV-patients without HHV-8 and those infected with unrelated viruses also develop angiopathies...
  93. pmc Induction of B cell hyperplasia in simian immunodeficiency virus-infected rhesus macaques with the simian homologue of Kaposi's sarcoma-associated herpesvirus
    S W Wong
    Division of Pathobiology, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    J Exp Med 190:827-40. 1999
    A simian homologue of Kaposi's sarcoma-associated herpesvirus (KSHV), the eighth human herpesvirus (HHV8), was isolated from a simian immunodeficiency virus (SIV)-infected rhesus macaque (Macaca mulatta) that developed a multicentric ..
  94. pmc Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensab
    Hari Raghu
    Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Virol 81:7941-59. 2007
    ..of human microvascular dermal endothelial (HMVEC-d) cells, Kaposi's sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8 [HHV-8]) induces the host cell's preexisting FAK, Src, phosphatidylinositol 3-kinase (PI3-K), Rho-GTPases, ..
  95. ncbi Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders
    M Q Du
    Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Blood 97:2130-6. 2001
    In a previous study, it was shown that the Kaposi sarcoma-associated herpesvirus (KSHV) was specifically associated with monotypic (IgMlambda) plasmablasts in multicentric Castleman disease (MCD)...
  96. ncbi [Detection of HHV8 latent nuclear antigen by immunohistochemistry. A new tool for differentiating Kaposi's sarcoma from its mimics]
    Philippe Courville
    Service d Anatomie et de Cytologie Pathologiques, Hopital Charles Nicolle, CHU de Rouen, Cedex, France
    Ann Pathol 22:267-76. 2002
    The purpose of this work was to study the value of HHV8 latent nuclear antigen 1 detection by immunohistochemistry in Kaposi sarcoma and its mimics.
  97. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    Kaposi's sarcoma-associated herpesvirus (KSHV) envelope-associated glycoprotein B (gB) is involved in the initial steps of binding to host cells during KSHV infection...
  98. doi Accumulation of LANA at nuclear matrix fraction is important for Kaposi's sarcoma-associated herpesvirus replication in latency
    Eriko Ohsaki
    Department of Infectious Diseases, University of Hamamatsu School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Virus Res 139:74-84. 2009
    The Kaposi's sarcoma-associated herpesvirus (KSHV) genome replicates once per cell cycle, and the number of viral genome is maintained in the latency...
  99. pmc The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques
    A Gregory Bruce
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Virol J 6:205. 2009
    ORF59 DNA polymerase processivity factor of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), is required for efficient copying of the genome during virus replication...
  100. pmc Rhesus rhadinovirus infection of rhesus fibroblasts occurs through clathrin-mediated endocytosis
    Wei Zhang
    The University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Virol 84:11709-17. 2010
    Rhesus rhadinovirus (RRV) is a gammaherpesvirus closely related to Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic virus linked to the development of Kaposi's sarcoma and several other lymphoproliferative diseases, including ..
  101. ncbi Mechanisms of expression of HHV8, EBV and HPV in selected HIV-associated oral lesions
    J J Hille
    Department of Oral and Maxillofacial Pathology, University of the Western Cape, Cape Town, South Africa
    Oral Dis 8:161-8. 2002
    ..OHL), have been tested for the prevalence of Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). While EBV DNA is detected by PCR in all of these lesions, abundant viral replication can only be detected in OHL...

Research Grants78

  1. Warren Phipps; Fiscal Year: 2015
    ....
  2. EMILY MARIE COUSINS; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) has been etiologically linked to Kaposi sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL)...
  3. Erle S Robertson; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Kaposi's sarcoma associated herpesvirus (KSHV/HHV-8) is associated with a number of human cancers in particular AIDS associated Kaposi sarcoma (KS) and pleural effusion lymphomas (PELs)...
  4. Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization
    Ronald C Desrosiers; Fiscal Year: 2012
    ..The gamma-2 herpesvirus of rhesus monkeys, rhesus monkey rhadinovirus (RRV), will be used as a model of human herpesvirus 8 (HHV-8;the Kaposi sarcoma-associated herpesvirus) to define the viral glycoproteins required for entry into ..
  5. Corey Casper; Fiscal Year: 2014
    ..Kaposi sarcoma (KS), the most common HIV-associated malignancy worldwide, is attributable to infection with human herpesvirus 8 (HHV-8)...
  6. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups...
  7. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosupressed persons and in other groups...
  8. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups...
  9. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosupressed persons and in other groups...
  10. Ren Sun; Fiscal Year: 2016
    ..of human gamma-herpesviruses, Epstein-Barr virus (EBV or HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8), are associated with several malignancies, which frequently develop in immunodeficiency virus (HIV)-..
  11. Erle S Robertson; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Kaposi's sarcoma associated herpes virus (KSHV/HHV-8) is the second identified gammaherpesvirus associated with at least 3 major proliferative diseases...
  12. Infection of primary B cells by the human lymphomagenic pathogen HHV8
    Lynn M Hassman; Fiscal Year: 2012
    ..lymphoma (PEL) and multicentric Castleman's disease arise in immunocompromised patients harboring human herpesvirus 8 (HHV8), the same oncogenic pathogen underlying Kaposi's sarcoma...
  13. Role of ROS and Nrf2 in HHV-8 infection and pathogenesis
    Virginie Bottero; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8/KSHV) is etiologically associated with Kaposi's Sarcoma (KS), primary effusive lymphoma (PEL), and multicentric Castleman disease (MCD)...
  14. KSHV-Ori-Lyt-Dependent DNA Replication
    Yan Yuan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 (HHV-8), is a human pathogen responsible for several AIDS associated malignancies including Kaposi's sarcoma ..
  15. Dean H Kedes; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8) establishes lifelong infection and is the etiologic agent underlying primary effusion lymphoma, ..
  16. Antigens of Kaposi's sarcoma associated herpesvirus
    Bala Chandran; Fiscal Year: 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated in the pathogenesis of Kaposi's sarcoma (KS), an AIDS-defining vascular tumor...
  17. Paul M Lieberman; Fiscal Year: 2015
    ..PUBLIC HEALTH RELEVANCE: Human herpesvirus 8 (HHV8), more commonly referred to as Kaposi's Sarcoma (KS)-Associated Herpesvirus (KSHV) is the ..
  18. Subhash C Verma; Fiscal Year: 2016
    ..in regulating lytic DNA replication of Kaposi's sarcoma associated herpesvirus (KSHV) also known as Human Herpesvirus 8 (HHV8)...
  19. Scott W Wong; Fiscal Year: 2016
    ..One virus that was recently identified to be associated with cancer in humans in 1995 is human herpesvirus 8 (HHV8)/Kaposi's sarcoma-associated herpesvirus (KSHV)...
  20. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) is the etiologic agent of KS, the most common cancer associated with HIV infection and AIDS...
  21. Ethel Cesarman; Fiscal Year: 2015
    ..KS is caused by the Kaposi's sarcoma herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8)...
  22. John Nicholas; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies a homologue of interleukin-6, vIL-6, which is implicated in the development and progression of HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (..
  23. HHV-8, angiogenesis and inflammation
    Bala Chandran; Fiscal Year: 2011
    ..abstract_text> ..
  24. Steven D Dong; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Kaposi's sarcoma herpes virus (KSHV) also known as human herpes virus 8 (HHV-8) causes several cancers including Kaposi's sarcoma, primarily in immune-compromised patients...
  25. Transmission of KSHV/HHV-8 in South Africa
    Lisa Michelle Butler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpes-virus (KSHV) is now known to be the viral etiologic agent of Kaposi's sarcoma...
  26. Activities of HHV-8 vIRF-1 in Virus Biology
    John Nicholas; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies four viral interferon regulatory factor homologues (vIRFs) that function to inhibit cellular IRFs in addition to other components of cellular defense pathways ..
  27. John Nicholas; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Kaposi's sarcoma- and B cell lymphoma-associated human herpesvirus 8 (HHV-8) specifies particular proteins that are believed to contribute to angioproliferative and malignant pathogenesis...
  28. Function of gammaherpesvirus ORF75 tegument proteins
    Laurie T Krug; Fiscal Year: 2013
    ..The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are leading causes of herpesvirus-associated morbidity and mortality worldwide...
  29. John Nicholas; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) is associated with endothelial Kaposi's sarcoma (KS) and B cell malignancies primary effusion lymphoma and multicentric Castleman's disease, all of which occur ..
  30. MODULATION OF ONCOGENIC AGENTS BY MARIJUANA
    PETER GABOR MEDVECZKY; Fiscal Year: 2010
    ..Epstein-Barr virus (EBV) and the Kaposi's Sarcoma Associated Herpesvirus (KSHV/HHV-8) are implicated as causative agents of malignant lymphomas in AIDS patients, in aging individuals, and organ ..
  31. A High Throughput Protein Complementation Assay for Inhibitors of NEMO-K13 Intera
    Preet M Chaudhary; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human Herpesvirus 8 (HHV8, also known as KSHV) is one of the commonest causes of malignancies among young adults in parts of the world and has been associated with Kaposi's sarcoma, primary ..
  32. Ren Sun; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Gamma-herpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), Epstein-Barr virus (EBV), and murine herpesvirus 68 (MHV68) can establish lifelong persistent infection in ..
  33. Role of Arsenic Trioxide in Primary Effusion Lymphoma
    Preet M Chaudhary; Fiscal Year: 2011
    Human herpes virus 8 (HHV8), also known as Kaposi's sarcoma associated herpes virus (KSHV) is the most frequent cause of malignancy among AIDS patients...
  34. Mechanisms of Action of LANA encoded by KSHV
    Erle S Robertson; Fiscal Year: 2011
    The Kaposi's sarcoma associated herpes virus (KSHV/HHV-8) is a gammaherpesvirus associated with human malignancies including Kaposi's sarcoma and body cavity based lymphomas (BCBLs) or Pleural Effusion Lymphomas (PELs)...
  35. Immune surveillance in murine gammaherpesvirus infection
    Edward J Usherwood; Fiscal Year: 2013
    ..There is a good likelihood that therapies similar to those we describe will be effective in humans, and our studies provide essential information concerning their method of action. ..
  36. Dirk P Dittmer; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): This is the renewal application for RO1 CA109232 Regulation of the KSHV LANA promoter...
  37. Young Bong Choi; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) encodes non-structural proteins that regulate host cell antiviral mechanisms via multiple inhibitory interactions...
  38. Mitochondrial-localized activities of HHV-8 vIRF-1
    John Nicholas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human herpesvirus 8 (HHV-8) specifies four viral interferon regulatory factor homologues (vIRFs 1-4) that function to inhibit cellular IRFs in addition to other components of cellular defense ..
  39. Charles Wood; Fiscal Year: 2015
    ..Human herpesvirus-8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with KS...
  40. KSHV proteins eliciting neutralizing antibodies and T cell responses
    Jeffrey Vieira; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is the etiologic agent of Kaposi's sarcoma (KS), and other proliferative disorders...
  41. Re-specification of the Notch response by the HHV-8 lytic switch protein
    David M Lukac; Fiscal Year: 2013
    ..This proposal will shed light on how Notch target genes are specified, and reveal new components of the Notch signal transduction pathway. ..
  42. NATURAL HISTORY AND TRANSMISSION OF HHV8/KSHV
    Dennis Osmond; Fiscal Year: 2001
    ..of human herpes virus is proposed to (1) identify biologic and behavioral risk factors for acquisition of HHV-8/KSHV infection and (2) describe patterns for HHV- 8/KSHV virologic activity, types of host immunologic response, and the ..
  43. KSHV PUTATIVE ONCOGENES IN AIDS MALIGNANCIES
    Ethel Cesarman; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Description) The Kaposi's sarcoma-associated herpesvirus (KS or human herpesvirus 8 (HHV 8) is consistently present in Kaposi's sarcoma and primary effusion (body cavity-based) lymphoma, two malignancies ..
  44. Morpholino Antisense Drugs for Human Herpesvirus 8
    Yan Jin Zhang; Fiscal Year: 2005
    ..occurrence is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8. KSHV is potentially oncogenic because it cause transformation of human primary endothelial cells, and some ..
  45. Blossom A Damania; Fiscal Year: 2016
    ..its focus on the human oncogenic herpesvirus, Epstein-Barr Virus (EBV) and Kaposi Sarcoma-associated Herpesvirus (KSHV) to identify the critical mechanisms by which these agents induce cancer and deregulate cell growth...
  46. Targeting Kinases that Phosphorylate the KSHV LANA Chromatin Binding Domain
    S Diane Hayward; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): KSHV is associated with the endothelial malignancy Kaposi sarcoma (KS) and the B cell cancers primary effusion lymphoma (PEL) and multicentric Castleman disease...
  47. Fengchun Ye; Fiscal Year: 2014
    ..such as herpes simplex virus (HSV), Epstein Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV). The oral cavity is also a potential reservoir for latent HIV infection...
  48. The role of cell surface heat shock protein 90 in KSHV pathogenesis
    MICHAEL ROBERT DEFEE; Fiscal Year: 2013
    ..Kaposi's sarcoma-associated herpesvirus (KSHV), the etiologic agent of KS, activates signal transduction pathways responsible for promoting viral oncogene ..
  49. Transport and Insertion of Outer Membrane Proteins
    Sangita Sinha; Fiscal Year: 2009
    ..include EBV, which causes infectious mononucleosis and malignant tumors of lymphoid and epithelial tissues, and KSHV, which causes Kaposi sarcoma tumors, especially among immuno-compromised individuals such as AIDS patients and ..
  50. Peptide-mediated immunotherapy of KSHV-associated malignancy.
    Jae U Jung; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Peptide-mediated immunotherapy of KSHV-associated malignancy Research Area: 5-DE-109 Novel Immunotherapies to Treat HIV/AIDS-related Oral Manifestations and AIDS Malignancies Kaposi sarcoma (KS), ..
  51. Herpresviral Gene Expression in Kaposis Sarcoma
    Don Ganem; Fiscal Year: 2010
    ..tumor in that (i) it is precipitated by infection with a novel herpesvirus, known as KS-associated herpesvirus (KSHV);and (ii) it is accompanied by striking inflammatory and angiogenic processes, which it induces and on which it ..
  52. KAPOSIS SARCOMA ASSOCIATED VIRUS IN AIDS/LYMPHOMAS
    Ethel Cesarman; Fiscal Year: 1999
    ..studies proposed here is to determine the role of the recently identified Kaposi's sarcoma-associated herpesvirus (KSHV) in the pathogenesis of AIDS-associated body cavity based lymphomas (AIDS-BCBLs)...
  53. Dirk P Dittmer; Fiscal Year: 2016
    ..ml, not much is known about the long-term effect of these ART drugs on Kaposi sarcoma associated herpesvirus (KSHV) transmission and disease...
  54. ACTIVATION OF KAPOSI SARCOMA-ASSOCIATED HERPES VIRUS
    I Miller; Fiscal Year: 2003
    ..from the Applicant's Abstract): The gammaherpesvirus variably known as Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus eight (HHV8) is the likely etiologic agent of two malignancies, Kaposi's sarcoma (KS) and ..
  55. REGULATION OF ANGIOGENESIS BY HUMAN HERPESVIRUS 8
    Sankar Swaminathan; Fiscal Year: 2000
    b>Human herpesvirus 8 (HHV8) is a recently described DNA virus with demonstrated oncogenic and angiogenic properties...
  56. EPIDEMIOLOGY OF KSHV AND AIDS-RELATED KAPOSIS SARCOMA
    Lisa Jacobson; Fiscal Year: 1999
    ..epidemiology of HIV-1 related Kaposi's sarcoma (KS) as it relates to the putative causal agent, KS herpes virus (KSHV)...
  57. KSHV Modulation of the Host Innate Immune System
    John West; Fiscal Year: 2009
    ..by applicant): We hypothesize that Toll like receptors play an important role in the innate immune response to KSHV infection. We have preliminary data indicating that TLR signaling is induced upon infection of monocytes with KSHV...
  58. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Epstein Barr Virus (EBV) and Kaposi's sarcoma associated herpesvirus (KSHV) are associated with AIDS related cancers and human cytomegalovirus (HCMV) with severe retinitis and pneumonitis in ..
  59. PAUL DALLING LING; Fiscal Year: 2014
    ..Human gammaherpesviruses, exemplified by Epstein-Barr virus and Kaposi's Sarcoma herpesvirus (EBV and KSHV), are significant causes of human disease, including cancer...
  60. Control of Gammaherpesvirus Replication
    Samuel H Speck; Fiscal Year: 2013
    ..b. Identify and characterize mLANA associated proteins;and Aim 3.c. Assess whether functional domains in KSHV LANA and mLANA are interchangable...
  61. Generation and Evaluation of KSHV VLPs as Vaccines
    GARY S contact HAYWARD; Fiscal Year: 2010
    ..by a previously unknown human herpesvirus called Kaposi's Sarcoma Associated Herpesvirus (KSHV or sometimes HHV8)...
  62. Modulation of histone deacetylase activity by a gammaherpesviral kinase
    Bryan C Mounce; Fiscal Year: 2013
    ..The human gammaherpesviruses Epstein-Barr Virus (EBV) and Kaposi's Sarcoma Associated Herpesvirus (KSHV) are associated with diverse diseases, including several cancers...
  63. Paul M Lieberman; Fiscal Year: 2016
    ..novel insight into the genome maintenance mechanisms shared by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA and human papillomavirus (HPV) E2 family members, as well as by cellular factors that protect fragile genetic ..
  64. KSHV TRANSFORMATION AND ANGIOGENESIS IN KAPOSIS SARCOMA
    Ethel Cesarman; Fiscal Year: 2001
    Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV 8), is invariably present in Kaposi's sarcoma (KS) lesions where it has been localized in the endothelial cells as well as in the spindle cells, which are ..
  65. Interferon and Kaposi's sarcoma herpesvirus interaction
    Jinzhong Wang; Fiscal Year: 2009
    Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), the most common neoplasm in untreated HIV-1 infected individuals...
  66. INTERACTIONS BETWEEN HIV AND KSHV
    Charles Wood; Fiscal Year: 2001
    ..Recent studies have identified a new human herpesvirus, Kaposi's sarcoma associated herpesvirus (KSHV) or Human herpesvirus-8 (HHV-8), found in almost all KS tissues and body-cavity based lymphomas...
  67. Real-time high throughput PCR for microbial pathogens
    DIRK DITTMER; Fiscal Year: 2003
    Kaposi's Sarcoma-associated Herpesvirus (KSHV/HHV-8) is a prime example of an infectious etiological agent of cancer, discovered using molecular techniques (representational difference analysis (RDA) rather than conventional culture ..
  68. Immediate-Early Genes of KSHV
    Yan Yuan; Fiscal Year: 2009
    Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8), is closely associated with the most common malignancies in AIDS patients, Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL)...
  69. Development of a novel vaccine for protection against gammaherpesvirus infection
    Blossom A Damania; Fiscal Year: 2010
    ..with increased incidences of multiple tumors, many of which are associated with oncogenic tumor viruses like KSHV, Epstein-Barr virus (EBV), or human papillomavirus (HPV)...
  70. PF-8 AND POL-8 OF KSHV AS TARGETS OF VIRAL DNA SYNTHESIS
    Robert Ricciardi; Fiscal Year: 2001
    DESCRIPTION: (Adapted from Applicant's Abstract) Kaposi's sarcoma-associated herpesvirus (KSHV) is the apparent etiological cause of Kaposi's sarcoma, a neoplasm of frequent occurrence in HIV infected individuals...
  71. Enhanced Cell-mediated Immunogenicity of KSHV LANA1 Protein
    Patrick S Moore; Fiscal Year: 2010
    ..The importance of cellular immune surveillance in controlling Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8)-related malignancies is reflected by the high rate of disease among immunosuppressed (AIDS and transplant) ..
  72. HUMAN HERPESVIRUS 8 INFECTION IN ZIMBABWE
    Thomas Campbell; Fiscal Year: 2001
    ..of KS in persons with, and without AIDS has been linked to infection with the recently discovered human herpesvirus 8 (HHV-8; also called Kaposi's sarcoma-associated virus or KSHV)...
  73. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..the intersection between the HIV epidemic and the endemic nature of Kaposi's sarcoma-associated herpesvirus (KSHV) infection has caused Kaposi's sarcoma (KS) to become the most common malignancy in many parts of the region...
  74. Assay Development for Inhibitors of KSHV
    Paul M Lieberman; Fiscal Year: 2010
    ..screen for identification of small molecule inhibitors of Kaposi's Sarcoma Associated Herpes virus (KSHV) and associated diseases. KSHV is a human herpes virus and the causative agent of Kaposi's sarcoma's (KS)...
  75. MANIPULATION OF KINASE ACTIVITY BY KSHV LANA
    S Diane Hayward; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Kaposi's sarcoma associated herpesvirus (KSHV) is associated with the endothelial lesion Kaposi's sarcoma and the B cell malignancies primary effusion lymphoma and multicentric Castleman&..
  76. Immune Evasion and Protein Trafficking Piracy by KSHV
    Robert Means; Fiscal Year: 2004
    Kaposi's sarcoma-associated herpesvirus (KSHV) is the most recently described oncogenic, human herpesvirus...
  77. Genetic system for thesus monkey rhadinovirus (RRV)
    Blossom Damania; Fiscal Year: 2005
    Kaposi's sarcoma-associated herpesvirus (KSHV) has implicated Kaposi's sarcoma (KS), as well as primary effusion lymphomas (PELs) and multicentric Castleman's disease (MCD)...
  78. Cis and Trans acting factors for HHV8 lytic replication
    Gregory Pari; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) lytic DNA replication is directed by one of two cis acting lytic origins within the genome...

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  11. Immunotoxins for the treatment of diseases related to cmv infection
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