Hepatitis B virus

Summary

Alias: Human hepatitis B virus, hepatitis B virus (HBV), hepatitis B virus HBV, hepatitis B virus, HBV, human hepatitis B virus HBV, HBV

Top Publications

  1. ncbi Molecular functions and biological roles of hepatitis B virus x protein
    Hong Tang
    Division of Biotherapy of Infectious Diseases, Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, Chengdu, Sichuan, China
    Cancer Sci 97:977-83. 2006
  2. pmc Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations
    Jeong Han Kim
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:257-64. 2010
  3. doi Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis
    Y Z Zhu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    J Viral Hepat 17:98-107. 2010
  4. doi The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein
    Congwen Wei
    Beijing Institute of Biotechnology, China
    J Immunol 185:1158-68. 2010
  5. doi Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
    Jiejie Xu
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Institute of Medical Microbiology, Shanghai, People s Republic of China
    Hepatology 52:142-54. 2010
  6. pmc The arginine clusters of the carboxy-terminal domain of the core protein of hepatitis B virus make pleiotropic contributions to genome replication
    Eric B Lewellyn
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Ave, Madison, WI 53706, USA
    J Virol 85:1298-309. 2011
  7. doi The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation
    Dong Ji
    Institute of Infectious Diseases and Liver Failure Research Center, Beijing 302 Hospital, Beijing 100039, China
    J Clin Virol 54:66-72. 2012
  8. pmc Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression
    Bouchra Kitab
    Laboratoire des hépatites virales, Institut Pasteur du Maroc, Casablanca, Morocco
    PLoS ONE 7:e42891. 2012
  9. pmc Hepatitis B virus X protein interacts with a probable cellular DNA repair protein
    T H Lee
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030
    J Virol 69:1107-14. 1995
  10. ncbi Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism
    Won Ho Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:40-8. 2005

Research Grants

  1. Radhakrishnan P Iyer; Fiscal Year: 2015
  2. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
  3. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2012
  4. NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE
    BRIAN JAMES MCMAHON; Fiscal Year: 2012
  5. Development of Sulfamoylbenzamide Derivatives as Antiviral Agents against HBV Inf
    Xiaodong Xu; Fiscal Year: 2012
  6. Christoph Seeger; Fiscal Year: 2014
  7. Urtzi Garaigorta; Fiscal Year: 2015
  8. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
  9. Development of Fluorinated Sulfamoylbenzamide Derivatives as Antiviral Agents aga
    Xiaodong Xu; Fiscal Year: 2013
  10. Aleem Siddiqui; Fiscal Year: 2014

Patents

  1. MODIFIED HEPATITIS POST-TRANSCRIPTIONAL REGULATORY ELEMENTS
  2. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
  3. CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
  4. Recombinant self-assembling protein comprising a target-specfic peptide and use thereof
  5. CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
  6. REMODELING AND GLYCOCONJUGATION OF PEPTIDES
  7. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
  8. VACCINE
  9. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
  10. COMBINED TREATMENT WITH A TLR7 AGONIST AND AN HBV CAPSID ASSEMBLY INHIBITOR

Detail Information

Publications241 found, 100 shown here

  1. ncbi Molecular functions and biological roles of hepatitis B virus x protein
    Hong Tang
    Division of Biotherapy of Infectious Diseases, Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, Chengdu, Sichuan, China
    Cancer Sci 97:977-83. 2006
    Chronic infection of hepatitis B virus (HBV) is one of the major causes of hepatocellular carcinoma (HCC) in the world...
  2. pmc Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations
    Jeong Han Kim
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:257-64. 2010
    The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes...
  3. doi Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis
    Y Z Zhu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    J Viral Hepat 17:98-107. 2010
    ..methyl-CpG binding domain protein 2 (MBD2) in the process of HBx induced p16(INK4A) promoter hypermethylation in HBV-related hepatocellular carcinoma (HCC) and their corresponding noncancerous liver tissues...
  4. doi The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein
    Congwen Wei
    Beijing Institute of Biotechnology, China
    J Immunol 185:1158-68. 2010
    ..For human hepatitis B virus (HBV), hepatitis B s-Ag, hepatitis B e-Ag, or HBV virions have been shown to suppress TLR-induced ..
  5. doi Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
    Jiejie Xu
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Institute of Medical Microbiology, Shanghai, People s Republic of China
    Hepatology 52:142-54. 2010
    One of the serious sequelae of chronic hepatitis B virus (HBV) infection is hepatocellular carcinoma (HCC)...
  6. pmc The arginine clusters of the carboxy-terminal domain of the core protein of hepatitis B virus make pleiotropic contributions to genome replication
    Eric B Lewellyn
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Ave, Madison, WI 53706, USA
    J Virol 85:1298-309. 2011
    The carboxy-terminal domain (CTD) of the core protein of hepatitis B virus is not necessary for capsid assembly. However, the CTD does contribute to encapsidation of pregenomic RNA (pgRNA)...
  7. doi The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation
    Dong Ji
    Institute of Infectious Diseases and Liver Failure Research Center, Beijing 302 Hospital, Beijing 100039, China
    J Clin Virol 54:66-72. 2012
    It remains unclear whether hepatitis B virus (HBV) reverse-transcriptase (RT) rtL229 substitutions influence HBV drug resistance.
  8. pmc Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression
    Bouchra Kitab
    Laboratoire des hépatites virales, Institut Pasteur du Maroc, Casablanca, Morocco
    PLoS ONE 7:e42891. 2012
    b>Hepatitis B virus (HBV) is one of the most common human pathogens that cause aggressive hepatitis and advanced liver disease (AdLD), including liver cirrhosis and Hepatocellular Carcinoma...
  9. pmc Hepatitis B virus X protein interacts with a probable cellular DNA repair protein
    T H Lee
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030
    J Virol 69:1107-14. 1995
    The mechanism of action of hepatitis B virus (HBV) X protein in transcriptional transactivation and in tumorigenesis remains obscure...
  10. ncbi Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism
    Won Ho Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:40-8. 2005
    ..In this paper, we demonstrated that primary hepatocytes from transgenic mice overexpressing hepatitis B virus X protein (HBX) were more susceptible to ethanol- and TNF-alpha-induced apoptotic killing...
  11. pmc Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication
    Michael J Bouchard
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Virol 80:4406-14. 2006
    The hepatitis B virus (HBV) X protein (HBx) is a multifunctional regulator of cellular signal transduction and transcription pathways and has a critical role in HBV replication...
  12. ncbi Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India
    Ranjit Chauhan
    Department of Gastroenterology, and Advanced Center for Liver Diseases, G B Pant Hospital, New Delhi, India
    J Med Virol 78:1047-54. 2006
    Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease...
  13. ncbi Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
    Baozong Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    Virus Res 124:44-9. 2007
    Numerous viruses including hepatitis B virus (HBV) induce endoplasmic reticulum (ER) stress, which interrupts protein folding causing accumulation of unfolded or misfolded proteins in ER...
  14. doi Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression
    J Du
    Department of Immunology, School of Medicine, Shandong University, Jinan, China
    Cell Death Differ 16:219-29. 2009
    b>Hepatitis B virus (HBV) causes chronic hepatitis in hundreds of millions of people worldwide, which can eventually lead to hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV persistence are not well understood...
  15. pmc Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice
    Victor V Keasler
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Virology 390:122-9. 2009
    Identifying the requirements for the regulatory HBx protein in hepatitis B virus (HBV) replication is an important goal...
  16. pmc Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections
    Ho Suk Mun
    Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    J Virol 85:123-32. 2011
    Several lines of evidence have suggested that some naturally occurring mutations of hepatitis B virus (HBV) play a critical role in hepatocellular carcinoma (HCC). Here, we describe a novel HCC-related pre-S2 mutation, F141L...
  17. pmc Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival
    Shoba Iyer
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Mol Carcinog 50:972-80. 2011
    This study examines the differential activities between wild-type Hepatitis B virus X protein (WtHBx) and a mutant HBx (MutHBx), which bears a hotspot mutation at nucleotides 1,762 and 1,764, resulting in a lysine to methionine change at ..
  18. pmc Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication
    Amanda J Hodgson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 426:73-82. 2012
    Robust hepatitis B virus (HBV) replication is stimulated by the regulatory HBx protein. HBx binds the cellular protein DDB1; however, the importance of this interaction for HBV replication remains unknown...
  19. doi Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy
    Florian van Bömmel
    Department of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig, Leipzig, Germany
    Antivir Ther 17:1049-58. 2012
    Tenofovir disoproxil fumarate (TDF), an acyclic nucleotide analogue was shown to be effective in many HBV-infected patients with resistance to adefovir dipivoxil (ADV)...
  20. pmc XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation
    N Kuzhandaivelu
    Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida, Tampa 33612, USA
    Nucleic Acids Res 24:4741-50. 1996
    The hepatitis B virus X protein is a promiscuous transcriptional transactivator. Transactivation by the X protein is most likely mediated through binding to different cellular factors...
  21. pmc Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication
    M Melegari
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, and Harvard Medical School, Charlestown 02129, USA
    J Virol 72:1737-43. 1998
    The hepatitis B virus and the mammalian hepadnavirus genomes encode for a short open reading frame called x. Expression of the protein product (HBx) appears necessary for establishment of natural infection...
  22. pmc Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death
    Olivier Leupin
    Department of Microbiology and Molecular Medicine, University Medical Centre, Geneva, Switzerland
    J Virol 79:4238-45. 2005
    The hepatitis B virus (HBV) X protein (HBx) is essential for virus infection and has been implicated in the development of liver cancer associated with chronic infection...
  23. pmc Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
    Paloma Sanz-Cameno
    Hepatology Planta 3, Hospital Universitario de la Princesa, Diego de Leon 62, E 28006, Madrid, Spain
    Am J Pathol 169:1215-22. 2006
    ..b>Hepatitis B virus (HBV) X protein transactivator (HBx) may play a significant role in both processes...
  24. ncbi The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases
    Di Peng Ou
    Liver Cancer Laboratory, Department of Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Int J Cancer 120:1208-14. 2007
    The hepatitis B virus (HBV) is a major cause of human hepatocellular carcinoma (HCC) which has a very high mortality rate due to high incidence of metastasis. It is unknown whether HBV contributes to HCC metastasis...
  25. doi Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2
    Jin Hee Wang
    Department of Biochemistry, Ajou University School of Medicine, San 5 Wonchun Dong, Yeongtang gu, Suwon 443 721, Korea
    Cancer Sci 99:888-93. 2008
    Multifunctional activities of the hepatitis B virus X-protein (HBx) in cells have been largely implicated in the development of liver cancer; one of these activities is the loss of p53 function by sequestering p53 in the cytoplasm...
  26. pmc Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    AMY J CLIPPINGER
    Graduate Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Virol 82:6798-811. 2008
    Over 350 million people are chronically infected with hepatitis B virus (HBV), and a significant number of chronically infected individuals develop primary liver cancer...
  27. doi Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria
    Hye Jin Kim
    Department of Microbiology, School of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Korea
    IUBMB Life 60:473-80. 2008
    b>Hepatitis B virus X protein (HBx) is essential for viral replication and plays an important role in viral pathogenesis...
  28. doi Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 373:643-7. 2008
    The role of the hepatitis B virus X protein (HBx) in hepatocarcinogenesis remains controversial...
  29. pmc Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy
    Lova Rakotomalala
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 283:28729-40. 2008
    b>Hepatitis B virus X protein (pX) is implicated in hepatocellular carcinoma pathogenesis by an unknown mechanism...
  30. pmc HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study
    Zhong Liao Fang
    Department of Medicine, Royal Free and University College Medical School, University College London, London, United Kingdom
    Am J Gastroenterol 103:2254-62. 2008
    ..We reported that 96% of HCC patients but only 24% of controls were infected with the hepatitis B virus (HBV) with A(1762)T, G(1764)A mutations in Guangxi, China...
  31. doi A new core promoter mutation and premature stop codon in the S gene in HBV strains from Iranian patients with cirrhosis
    M Veazjalali
    Virology Department, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    J Viral Hepat 16:259-64. 2009
    In order to define hepatitis B virus (HBV) mutational patterns in Iran, nucleotide sequences obtained from 91 patients and encompassing the precore, basal core promoter (BCP) and surface (S) regions, were compared...
  32. doi Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus
    Josephine Simonetti
    Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
    Hepatology 51:1531-7. 2010
    Some individuals who are chronically infected with hepatitis B virus (HBV) eventually lose hepatitis B surface antigen (HBsAg). Hepatocellular carcinoma (HCC) has been demonstrated to occur in a few patients after loss of HBsAg...
  33. pmc A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase
    Qi Wang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, China
    Acta Pharmacol Sin 31:367-74. 2010
    Previously, we identified a natural mutant of hepatitis B virus X gene (HBx) with a deletion from 382 to 401 base pairs (termed HBxDelta127), which could potently enhance growth of hepatoma cells...
  34. pmc Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3
    Kyeongjin Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
    PLoS ONE 5:e8649. 2010
    b>Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of HCV in associations with insulin signaling has been elucidated...
  35. doi Molecular biology of the hepatitis B virus and role of the X gene
    Y Wei
    Unité oncogenèse et virologie moléculaire, Departement de Virologie, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    Pathol Biol (Paris) 58:267-72. 2010
    The hepatitis B virus (HBV) is a widespread human pathogen and a major health problem in many countries...
  36. doi Hepatitis B virus BCP, Precore/core, X gene mutations/genotypes and the risk of hepatocellular carcinoma in India
    Mohammad Asim
    Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India
    J Med Virol 82:1115-25. 2010
    The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC)...
  37. pmc Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma
    Xin Bai
    Cancer Institute of Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, China
    Carcinogenesis 32:63-8. 2011
    To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC), we determined the sequence of Enh II/BCP in 152 HCC and 136 non-HCC patients from a ..
  38. doi Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients
    Seoung Ae Lee
    Department of Microbiology and Immunology, Liver Research Institute, College of Medicine, Seoul National University, Seoul, Korea
    J Med Virol 83:65-70. 2011
    Deletions and insertions in the hepatitis B virus (HBV) X region have been associated with severe forms of liver disease, including hepatocellular carcinoma (HCC)...
  39. pmc RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-κB signaling via its novel chaperoning function
    Keo Heun Lim
    Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
    PLoS ONE 6:e22258. 2011
    b>Hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC) development. Hepatitis B virus X protein (HBx) is known to play a key role in the development of hepatocellular carcinoma (HCC)...
  40. doi Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma
    Yonghong Lei
    Wound Healing and Cell Biology Laboratory, The First Affiliated Hospital, and Camital Medical University, Beijing 100853, PR China
    Oncol Rep 27:151-9. 2012
    The pre-S mutant LHBs, especially the pre-S2 type, is believed to be crucial in HBV-associated hepatocellular carcinogenesis. However, the mechanism of HBV-induced hepatocellular carcinoma is not fully understood...
  41. doi The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes
    Na Luo
    Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
    Virus Res 165:170-8. 2012
    b>Hepatitis B virus (HBV) infection is an important risk factor for hepatocellular carcinoma (HCC)...
  42. ncbi Correlation of the occurrence of YMDD mutations with HBV genotypes, HBV-DNA levels, and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment
    Feng Wu
    Department of Chinese Pharmacy, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 11:172-6. 2012
    ..The current study explores the association of the emergence of YMDD mutations with pretherapy HBV genotype, HBV-DNA levels, HBeAg status, and serum alanine aminotransferase (ALT) levels in Chinese patients ..
  43. pmc Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma
    Chia Jui Yen
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
    PLoS ONE 7:e41931. 2012
    ..carcinoma (HCC), a major cause of cancer-related death in Southeast Asia, is frequently associated with hepatitis B virus (HBV) infection...
  44. doi miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
    Xufu Wei
    Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Cell Signal 25:439-46. 2013
    The hepatitis B virus x (HBx) protein has been implicated in HBV-related hepatocellular carcinoma (HCC) pathogenesis...
  45. pmc Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma
    Yan Wu
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 9:e94864. 2014
    b>Hepatitis B Virus (HBV) mutations play a role in the development of hepatocellular carcinoma (HCC). However, the association between HBV polymerase gene mutations and HCC has not been reported...
  46. ncbi Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    Tae Wook Chung
    National Research Laboratories for Glycobiology, Ministry of Science and Technolgoy, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju, South Korea
    FASEB J 18:1123-5. 2004
    b>Hepatitis B virus (HBV) X protein (HBx) has been shown to be essential for the development of hepatocellular carcinoma (HCC)...
  47. ncbi Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
    Feng Ling Yu
    Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan, ROC
    J Hepatol 42:520-7. 2005
    b>Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. How this regulation influences HCC is unclear.
  48. ncbi Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1
    Jung Ok Lee
    Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Korea
    Oncogene 24:6617-25. 2005
    ..implicated as a tumor suppressor, which is frequently altered in hepatocellular carcinoma, especially in hepatitis B virus (HBV)-related tumors...
  49. ncbi Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Room 306 Cancer Center, Shatin, New Territories, Hong Kong
    J Clin Virol 34:7-12. 2005
    Chronic infection by hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) in man. The viral transactivator HBV X (HBx) gene plays a critical role in the molecular pathogenesis of HBV-related HCC.
  50. ncbi Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein
    Thi Thu Thuy Le
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    J Biochem 138:215-24. 2005
    ..b>Hepatitis B virus X protein (HBx) binds the central part of RPB5 to modulate activated transcription, and TFIIF subunit RAP30 ..
  51. ncbi Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Tianjin Key Laboratory of Microbial Functional Genomics, College of Life Sciences, Nankai University, Tianjin, P R China
    J Med Virol 77:374-81. 2005
    The hepatitis B virus X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). The relationship was examined between HBV antigens and IAP (inhibitor of apoptosis) family in development of HCC...
  52. ncbi Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter
    Sung Gyoo Park
    School of Biological Sciences, Institute of Microbiology, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 281:31770-7. 2006
    ..This HBx-mediated-cyclin D1 up-regulation might play an important role in the HBx-mediated HCC development and progression...
  53. ncbi Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
    Juan Gao
    Institute of Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Biochem Biophys Res Commun 356:341-7. 2007
    ..of Jagged1 in hepatocellular carcinoma (HCC) has not been elucidated, nor whether it is associated with hepatitis B virus X protein (HBx). In this study, we found that Jagged1 was highly expressed in 79...
  54. ncbi [A study in the Guizhou area on pre-S region mutations of hepatitis B virus]
    Mei Wang
    Department of Infectious Diseases, Guiyang Medical College, Guiyang 550004, China
    Zhonghua Gan Zang Bing Za Zhi 15:98-102. 2007
    To study the relationships between hepatitis B virus (HBV ) pre-S region mutations and their genotypes and the stages of liver disease of the patients.
  55. ncbi Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma
    Kook Hwan Kim
    Department of Molecular Biology, Pusan National University, Busan, Korea
    Gastroenterology 132:1955-67. 2007
    Hepatic steatosis occurs frequently in patients with chronic hepatitis B virus (HBV) or chronic hepatitis C virus (HCV) infection...
  56. ncbi Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials
    Katyna Borroto-Esoda
    Department of Clinical Virology, Gilead Sciences, Inc, 4 University Place, 4611 University Dr, Durham, NC 27707, USA
    J Hepatol 47:492-8. 2007
    ..Recent reports have proposed other ADV resistance (ADV-R) mutations. The aims of this study were to confirm the role of rtA181V and rtN236T in clinical resistance to ADV and to screen for other potential ADV-R mutations...
  57. ncbi Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma
    Zhi Yong Gao
    Department of Microbiology, Peking University Health Science Center, 38 Xueyuan Road, 100083, Beijing, China
    J Gastroenterol 42:761-8. 2007
    b>Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B...
  58. pmc Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers
    Myron J Tong
    The Liver Center, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    Liver Int 27:1356-63. 2007
    Chronic hepatitis B virus (HBV) infection is associated with hepatocellular carcinoma (HCC), and specific viral factors have been identified that may increase the risk for HCC development...
  59. ncbi Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5' stem-loop structure
    Dong Kyun Ryu
    Department of Biochemistry, Yonsei University, Seoul, 120 749, Republic of Korea
    Virology 373:112-23. 2008
    ..We conclude that the P protein suppresses translation of the pgRNA via a mechanism involving its interaction with the 5' epsilon sequence, a finding that implicates the coordinated switch from translation to genome replication...
  60. doi Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation
    Wei Lun Tsai
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Scand J Gastroenterol 43:196-201. 2008
    ..of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection...
  61. doi The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein
    Huahong Xie
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, Shaanxi Province, People s Republic of China
    Dig Dis Sci 53:3225-33. 2008
    ..HIF-1alpha expression was also found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein expression in vitro...
  62. pmc Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, People s Republic of China
    Carcinogenesis 29:1207-14. 2008
    The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx.
  63. doi Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease
    H Poustchi
    Medical Science, University Tehran, Iran
    J Viral Hepat 15:753-60. 2008
    The impact of mutations in the precore and basal core promoter (BCP) regions of the hepatitis B virus on the course of chronic liver disease is not well established...
  64. doi HBV X gene transfection upregulates IL-1beta and IL-6 gene expression and induces rat glomerular mesangial cell proliferation
    Hongzhu Lu
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:247-50. 2008
    The X gene of HBV encodes a 17-kD protein, termed HBx, which has been shown to function as a transcriptional trans-activator of a variety of viral and cellular promoter/enhancer elements...
  65. doi COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis
    Alfred S L Cheng
    Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Biochem Biophys Res Commun 374:175-80. 2008
    The oncogenic hepatitis B virus X protein (HBx) and cyclooxygenase (COX)-2 are highly co-expressed in chronic hepatitis, cirrhosis and well-differentiated hepatocellular carcinoma (HCC)...
  66. pmc Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis
    Wen Horng Wang
    Department of Basic Medical Sciences, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USA
    J Biol Chem 283:25455-67. 2008
    b>Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocellular carcinoma (HCC) pathogenesis by an unknown mechanism...
  67. doi High prevalence of hepatitis B virus pre-S mutation and its association with hepatocellular carcinoma in Qidong, China
    Zhigang Cao
    National Laboratory of Oncogene and Related Genes, Cancer Institute of Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Arch Virol 153:1807-12. 2008
    We investigated the frequency and the clinical relevance of hepatitis B virus (HBV) pre-S mutations in Qidong, China. The results showed HBV pre-S mutants were detected in 48.4% (47/97) of patients with HBV infection...
  68. doi Analysis of hepatitis B virus X gene phylogeny, genetic variability and its impact on pathogenesis: implications in Eastern Indian HBV carriers
    Sibnarayan Datta
    ICMR Virus Unit, Kolkata, ID and BG Hospital Campus, GB 4, 1st Floor East Wing, 57, Dr Suresh Chandra Banerjee Road, Pin 700010 Beliaghata, Kolkata, West Bengal, India
    Virology 382:190-8. 2008
    HBx genetic variability was explored in the Eastern Indian population with low HCC incidence. DNase I sensitive HBV DNA was detected in 53% samples, which differed significantly between clinical groups (P<0.001)...
  69. doi Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma
    Tae Young Na
    College of Pharmacy, Seoul National University, Seoul, Korea
    Hepatology 49:1122-31. 2009
    Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)-associated hepatic steatosis, its underlying molecular mechanism remains unclear...
  70. doi Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B
    Miki Murata
    Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan
    Hepatology 49:1203-17. 2009
    b>Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis B progression. Transforming growth factor beta (TGF-beta) signaling involves both tumor suppression and oncogenesis...
  71. doi Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression
    Man Young Cha
    Department of Biochemistry, Yonsei University, Seoul 120 749, Republic of Korea
    J Gen Virol 90:978-86. 2009
    HBx, a small regulatory protein of hepatitis B virus, plays an important role in stimulating viral genome replication. HBx was shown to be associated with diverse subcellular locations, such as the nucleus, cytoplasm and mitochondria...
  72. pmc Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore
    AMY J CLIPPINGER
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, USA
    J Virol 83:4718-31. 2009
    The hepatitis B virus (HBV) X protein (HBx) is a multifunctional protein that regulates numerous cellular signal transduction pathways, including those that modulate apoptosis...
  73. pmc Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling
    Wing Kin Sung
    Department of Computer Science, National University of Singapore, Singapore
    J Biol Chem 284:21941-54. 2009
    ..factor targets of HBx will enhance our understanding of the role of HBx in hepatocellular carcinogenesis and facilitate the design of better strategies in combating hepatitis B virus-associated hepatocellular carcinoma.
  74. pmc Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression
    Leo L Studach
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 2026, USA
    Hepatology 50:414-23. 2009
    Chronic hepatitis B virus (HBV) infection is linked to development of hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis acting as a weak oncogene or a cofactor in hepatocarcinogenesis...
  75. doi X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma
    Chang Soo Choi
    Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Korea
    J Med Virol 81:1721-5. 2009
    Specific mutations in the hepatitis B virus (HBV) genome have been reported to be associated with the development of hepatocellular carcinoma (HCC)...
  76. doi Hepatitis B precore/core promoter mutations in isolates from HBV-monoinfected and HBV-HIV coinfected patients: a 3-yr prospective study
    Lucila Cassino
    Centro Nacional de Referencia para el SIDA, Dto Microbiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Clin Virol 46:354-9. 2009
    The course of chronic HBV infection is modified by HIV-coexistence.
  77. doi Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis
    Shirine Benhenda
    Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Adv Cancer Res 103:75-109. 2009
    Despite the existence of effective vaccines, HBV infection remains a major health problem with 2 billion people infected worldwide...
  78. pmc Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
    Laura Belloni
    Laboratory of Gene Expression, Fondazione A Cesalpino, 00161 Rome, Italy
    Proc Natl Acad Sci U S A 106:19975-9. 2009
    b>HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins...
  79. pmc The role of mutations in core protein of hepatitis B virus in liver fibrosis
    Ashraf Mohamadkhani
    National Institute of Genetic Engineering and Biotechnology Tehran, Iran
    Virol J 6:209. 2009
    The core protein of hepatitis B virus encompasses B- and T-cell immunodominant epitopes and subdivided into two domains: the N-terminal and the functional C-terminal consisted phosphorylation sites...
  80. pmc A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase
    Qi Wang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, PR China
    Neoplasia 12:103-15. 2010
    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Hepatitis B virus X protein (HBx) contributes to the development of HCC, whereas HBx with COOH-terminal deletion is a frequent event in the HCC tissues...
  81. pmc Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes
    Yu Zhou
    Departments of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    J Biol Chem 285:12159-68. 2010
    ..In the present study, we demonstrate that hepatitis B virus protein X (HBx) increases IP-10 expression in a dose-dependent manner...
  82. doi Retrospective characterization of the S open reading frame of HBV isolated from children with membranous nephropathy treated with interferon-alpha2b
    Natasha Gous
    Hepatitis Virus Diversity Research Programme formerly MRC CANSA University Molecular Hepatology Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    Antivir Ther 15:61-9. 2010
    A causal relationship exists between HBV infection and membranous nephropathy. The association is especially close in Black children in sub-Saharan Africa...
  83. doi Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and
    Shiyan Yu
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Public Health, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
    J Gen Virol 91:2080-90. 2010
    b>Hepatitis B virus (HBV) infection remains one of the most serious health problems worldwide...
  84. doi Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2
    Changliang Shan
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Cell Res 20:563-75. 2010
    b>Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma. Here, we sought to identify the mechanisms by which HBx mediates liver cell proliferation...
  85. doi Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma
    Jianhua Yin
    Department of Epidemiology, Second Military Medical University, 800 Xiang yin Rd, Shanghai, China
    J Gastroenterol 45:1063-71. 2010
    The associations of nucleotide substitution mutations in the preS region of hepatitis B virus (HBV) with hepatocellular carcinoma (HCC) and cirrhosis remain unknown...
  86. doi Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells
    Feng Zhang
    Department of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi an, People s Republic of China
    J Med Virol 82:920-8. 2010
    b>Hepatitis B virus (HBV) infection is closely correlated with the development of hepatocellular carcinoma (HCC), in which hepatitis B virus X protein (HBx) plays crucial roles. HBx is believed to be a multifunctional oncoprotein...
  87. doi Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma
    Yu Zhu
    Shanghai Medical College, Fudan University, Shanghai, China
    Cancer Epidemiol Biomarkers Prev 19:2623-30. 2010
    Mutations in the hepatitis B virus (HBV) genome may influence the activity of liver disease. The aim of this study was to identify new viral variations associated with hepatocellular carcinoma (HCC).
  88. pmc Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex
    Xianmiao Wang
    College of Life Sciences, Modern Virology Center, Wuhan University, Wuhan 430072, China
    Cell Mol Immunol 7:341-8. 2010
    ..Here we found that hepatitis B virus (HBV)-encoded X protein (HBx) acts as an inhibitor of virus-triggered IRF3 activation and IFN-beta induction...
  89. doi Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma
    Jianhua Yin
    Department of Epidemiology, Second Military Medical University, Shanghai, China
    Am J Gastroenterol 106:81-92. 2011
    ..objective of this study was to determine the association of 19 mutations with frequencies ≥ 10% in the core promoter region of hepatitis B virus (HBV) with chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC).
  90. pmc The C-terminal region of the hepatitis B virus X protein is essential for its stability and function
    Rebecca A Lizzano
    Graduate Program in Molecular and Cellular Biology and Genetics, Drexel University College of Medicine, Philadelphia, PA 19102, United States
    Virus Res 155:231-9. 2011
    More than 350 million people worldwide are chronically infected with the human hepatitis B virus (HBV). Chronic HBV infections are associated with the development of hepatocellular carcinoma...
  91. pmc Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1
    Liang Hu
    International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, 225 Changhai Road, Shanghai 200438, China
    J Virol 85:3214-28. 2011
    b>Hepatitis B virus X protein (HBx) is implicated in the pathogenesis of hepatitis B virus (HBV)-associated liver diseases...
  92. pmc Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH
    Ishtiaq Qadri
    NUST Center of Virology and Immunology, National University of Science and Technology, Academic Block, Kashmir Highway, H 12 Islamabad, Pakistan
    BMC Microbiol 11:48. 2011
    b>Hepatitis B virus (HBV) infections play an important role in the development of hepatocellular carcinoma (HCC)...
  93. pmc Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication
    Wen Horng Wang
    Department of Basic Medical Sciences and Purdue University Center for Cancer Research, West Lafayette, IN, USA
    Hepatology 53:1137-47. 2011
    Chronic hepatitis B virus (HBV) infection is a major etiologic factor in hepatocellular carcinoma (HCC) pathogenesis, involving effects of chronic liver inflammation and of the weakly oncogenic HBV X protein (pX)...
  94. ncbi HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state
    Yan Hai Guo
    State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, The Fourth Military Medical University, Xi an, China
    Epigenetics 6:720-6. 2011
    b>HBV covalently closed circular DNA (cccDNA) is the template for the transcription of HBV. HBV core protein (HBc) is a main component of the HBV cccDNA minichromosome. However, the function of HBc in cccDNA is not fully understood...
  95. doi Hepatitis B virus X gene and hepatocarcinogenesis
    Sue Ann Ng
    University of New South Wales, Sydney, Australia
    J Gastroenterol 46:974-90. 2011
    Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide...
  96. doi Hepatitis B virus X protein enhances activation of nuclear factor κB through interaction with valosin-containing protein
    Bo Yan Jiao
    Key laboratory of Ministry of Education for Gastrointestinal Cancer, Research Center of Molecular Medicine, Fujian Medical University, 88 Jiaotong Road, Fuzhou 350004, People s Republic of China
    Arch Virol 156:2015-21. 2011
    b>Hepatitis B virus X protein (HBx protein) is a multifunctional regulatory protein. The transactivation of nuclear factor kappa B (NF-κB) by HBx protein has been shown to be of importance in the pathogenesis of HBV-related diseases...
  97. pmc Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition
    Qiuju Han
    Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan, China
    PLoS ONE 6:e27931. 2011
    RNA interference (RNAi) of virus-specific genes offers the possibility of developing a new anti-hepatitis B virus (anti-HBV) therapy. Recent studies have revealed that siRNAs can induce an innate immune response in vitro and in vivo...
  98. pmc S gene mutations of HBV in children with HBV-associated glomerulonephritis
    Hongzhu Lu
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Virol J 9:59. 2012
    b>Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a kind of immune complex-induced glomerulonephritis...
  99. doi Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV
    Min Ren
    Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
    Antiviral Res 94:225-31. 2012
    ..Infection with hepatitis B virus (HBV) causes chronic hepatitis and liver cirrhosis...
  100. doi The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction
    Andy Hong
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    Biochem Biophys Res Commun 423:6-12. 2012
    We identified the interaction between HBV X (HBx) protein and the oncogene AIB1 (amplified in breast cancer 1). A serine/proline motif (SSPSPS) in HBx was found to be required for the interaction...
  101. doi C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma
    Karen M F Sze
    State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong
    Hepatology 57:131-9. 2013
    Random integration of hepatitis B virus (HBV) DNA into the host genome is frequent in human hepatocellular carcinoma (HCC) and this leads to truncation of the HBV DNA, particularly at the C-terminal end of the HBV X protein (HBx)...

Research Grants75

  1. Radhakrishnan P Iyer; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Acute and chronic liver infections caused by Hepatitis B virus (HBV) constitute a major worldwide public health problem...
  2. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    There are an estimated 350 million people worldwide who are chronically infected with hepatitis B virus (HBV) and are at high risk for the development of hepatitis, cirrhosis (end stage liver disease) and hepatocellular carcinoma (HCC)...
  3. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2012
    Abstract The hepatitis B virus (HBV) remains a global cause of chronic liver diseases, including liver cirrhosis and cancer. Current antiviral therapy for chronic hepatitis B is only partially effective...
  4. NATURAL HISTORY PREVENTION OF VIRAL HEPATITIS IN ALASKA NATIVE PEOPLE
    BRIAN JAMES MCMAHON; Fiscal Year: 2012
    Infections from hepatitis A virus (HAV) and hepatitis B virus (HBV) are significant problems in Alaska Natives. Hepatitis A and B vaccines have been routine immunizations in Alaska Natives since 1984 and 1994, respectively...
  5. Development of Sulfamoylbenzamide Derivatives as Antiviral Agents against HBV Inf
    Xiaodong Xu; Fiscal Year: 2012
    ..develop newly discovered sulfamoylbenzamide derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection...
  6. Christoph Seeger; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Hepatitis B virus causes chronic infections in approximately 350 million people worldwide. All are at significantly increased risk of developing hepatocellular carcinoma...
  7. Urtzi Garaigorta; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that causes acute and chronic hepatitis and kills a million people each year from cirrhosis of the liver and hepatocellular ..
  8. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is the most common cause of chronic viral liver disease worldwide...
  9. Development of Fluorinated Sulfamoylbenzamide Derivatives as Antiviral Agents aga
    Xiaodong Xu; Fiscal Year: 2013
    ..fluorinated sulfamoylbenzamide (FSBA) derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection...
  10. Aleem Siddiqui; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus infections affect about 300 million people worldwide and constitute a significant risk factor for fibrosis and hepatocellular carcinoma (HCC)...
  11. HDV spread during chronic infection as a novel target for antiviral intervention
    Severin O Gudima; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus (HBV) infection is the main cause of hepatocellular carcinoma (HCC) worldwide and is responsible for 50-80% of all HCC cases...
  12. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..b>Hepatitis B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and ..
  13. Lishan Su; Fiscal Year: 2016
    ..There is currently no cure for the 350 million patients who are already chronically infected with hepatitis B virus (HBV)...
  14. Betty L Slagle; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus (HBV) infection affects approximately 350 million people worldwide and is a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC)...
  15. 2013 International Meeting on the Molecular Biology of Hepatitis B Viruses
    Shuping Tong; Fiscal Year: 2013
    ..since 1985, is the only forum that gathers the international community of researchers focusing on the hepatitis B virus (HBV) and the closely associated hepatitis delta virus (HDV)...
  16. Use of Lamivudine To Improve Efficacy of Neonatal HBV
    Henry Pollack; Fiscal Year: 2005
    Each year almost 20,000 children are born to hepatitis B virus (HBV)-infected women in the US. To prevent mother-to-child transmission of HBV, newborns receive Hepatitis B Immune Globulin (HBIG) and HBV vaccine...
  17. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a noncytopathic, hepatotropic DNA virus that results in a self-limited acute infection in a majority of otherwise healthy individuals but can also cause chronic infection, ..
  18. Chloe L Thio; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The majority of persons with chronic hepatitis B virus (HBV) infection live in resource-limited settings (RLS) such as China where 10-20% of the 780,000 HIV-infected patients are co-infected with HBV...
  19. Occult Hepatitis B Infection in South African HIV Patients
    Jason T Blackard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Globally, 350 million people are chronically infected with hepatitis B virus (HBV) - the world's leading cause of cirrhosis and hepatocellular carcinoma (HCC)...
  20. Ourania M Andrisani; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Chronic Hepatitis B Virus (HBV) infection is a major factor in the pathogenesis of hepatocellular carcinoma (HCC)...
  21. DRW HIV-Ab/HBsAg Duplex Rapid Test submission for FDA-PMA approval
    Helen Lee; Fiscal Year: 2009
    ..of human immunodeficiency virus (HIV) infection and hepatitis B surface antigen (HBsAg) for diagnosis of hepatitis B virus (HBV) infection...
  22. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    Chronic Hepatitis B virus (HBV) infection is linked to hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis by an unknown mechanism...
  23. Jessica Casciano; Fiscal Year: 2014
    ..to exposure to various toxins or infectious agents, the majority of HCC cases are associated with chronic hepatitis B virus (HBV) infections...
  24. Role of Hepatitis B virus X protein in HBV replication
    Michael J Bouchard; Fiscal Year: 2011
    Individuals with a chronic hepatitis B virus (HBV) infection of the liver have an increased risk for developing hepatocellular carcinoma (HCC)...
  25. Pavel A Petukhov; Fiscal Year: 2014
    ..approach to discover lead candidates suitable for further lead optimization as therapeutics for chronic hepatitis B virus (HBV) infections...
  26. Structural Studies of HBsAg: Support for Quentin Florence
    QUENTIN FLORENCE; Fiscal Year: 2009
    DESCRIPTION (provided by investigator): Hepatitis B virus (HBV) is a blood-born-associated virus that has infected over 2 billion people worldwide. It is also one of the major causes of liver cancer...
  27. Hepatitis B Virus PreS2 Mutant as Risk Factor for Hepatocellular Carcinoma
    Eric J Huang; Fiscal Year: 2010
    ..b>Hepatitis B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and hepatocellular ..
  28. Hee Soon Juon; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) infection is globally most common and serious viral infection of the liver. It can cause premature death from liver diseases or liver cancer...
  29. IDENTIFICATION OF A CELL RECEPTOR FOR HEPATITIS B VIRUS
    MARK PEEPLES; Fiscal Year: 1992
    ..an efficient, productive research group, capable of contributing significantly to the understanding of hepatitis B virus (HBV) and the diseases it causes...
  30. TRAM THUY TRAN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chronic hepatitis B virus (HBV) infection affects 350 million persons worldwide and approximately 1.5 million Americans...
  31. Anna S F Lok; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Decrease in incidence of acute hepatitis B virus (HBV) infection has not been translated into a corresponding decrease in prevalence of chronic infection...
  32. Discovery of Anti-HBV cccDNA Compounds from a Unique Natural Products Collection
    Andrea Cuconati; Fiscal Year: 2013
    ..by applicant): This is a proposal to implement a novel high throughput assay system to detect inhibitors of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance...
  33. Haitao Guo; Fiscal Year: 2015
    ..We will explore the development of a group of newly identified compounds that inhibit the formation of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which is not targeted by current available antiviral medications...
  34. Kyong Mi Chang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) is a hepatotropic, enveloped, partially double-stranded DMA virus that causes acute and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (HCC)...
  35. CD07-005, Translating Research into the Jade Ribbon Campaign
    Samuel So; Fiscal Year: 2009
    ..Major gaps exist in the timely identification and immunization of infants born to women infected with hepatitis B virus (HBV)...
  36. Understanding Immunopathogenesis of Hepatitis B Virus
    Jody L Baron; Fiscal Year: 2010
    b>Hepatitis B Virus (HBV)is a hepadnavirus that is a major cause of acute and chronic hepatitis in humans. Three hundred million people globally are chronically infected with HBV, making HBV one of the most common human pathogens...
  37. Novel HBV Therapeutic with Potential for Treatment of Drug-Resistant Infection
    Andrea Cuconati; Fiscal Year: 2013
    ..to advance development of disubstituted tetrahydro-triazolo-pyrimidines (TTPs) as specific inhibitors of hepatitis B virus surface antigen (HBsAg) secretion in chronic infection...
  38. HEPATITIS B VACCINE ACCEPTANCE AMONG STD PATIENTS
    Gregory Zimet; Fiscal Year: 1999
    ..is to identify psychological, behavioral, and environmental factors associated with accepting and completing hepatitis B virus (HBV) immunization among patients attending a sexually transmitted disease (STD) clinic located in Chicago, ..
  39. Mechanism of CCC DNA Synthesis in Hepatitis B Virus
    Christoph Seeger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Investigations on hepatitis B virus (HBV) and related animal viruses, particularly duck hepatitis B virus (DHBV), have provided a detailed model of the hepadnavirus replication cycle...
  40. DONNA LORRAINE WHITE; Fiscal Year: 2014
    ..sex hormone testosterone may play a role in increasing risk of liver cancer due to another viral infection, Hepatitis B virus. Our group recently demonstrated that increased testosterone levels were associated with significantly ..
  41. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..compared with adjacent non-tumor tissues, and test whether the miRNA methylation levels are different for hepatitis B virus (HBV) and hepatitis C virus (HCV)-related HCC;(2) To examine whether a subgroup of miRNA genes showing ..
  42. LESLEY SUEJEAN PARK; Fiscal Year: 2014
    ..population, impaired immune function, and high prevalence of liver cancer risk factors hepatitis C virus, hepatitis B virus, an alcohol abuse and dependency contribute to the rising incidence of liver cancer among PLWHA...
  43. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma (HCC)...
  44. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human ..
  45. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis C and hepatitis B virus infections in humans are characterized by hepatocellular necrosis, inflammation, and development of hepatoma...
  46. Role of Pellino1 in liver inflammation
    Liselotte E Jensen; Fiscal Year: 2010
    ..It is estimated that over 2 billion people worldwide are infected with hepatitis B virus (HBV) or hepatitis C virus (HCV)...
  47. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus, hepatitis C virus, hepatitis A virus, respiratory syncytial virus, and human immunodeficiency virus and ..
  48. Pathogenesis of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2011
    Many viral infections induce liver pathology, and the association of infection, by hepatitis B virus and hepatitis C virus, with the development of cirrhosis and hepatoma in humans, highlights the need to understand mechanisms regulating ..
  49. KATHERINE BREMPELIS; Fiscal Year: 2014
    ..site for the development of an immune response against pathogens such as Hepatitis C virus (HCV) and Hepatitis B virus (HBV), as well as the main site of alcohol metabolism...
  50. Alan S Perelson; Fiscal Year: 2016
    ..Infection by hepatitis C virus (HCV) and hepatitis B virus (HBV) continue to cause liver failure and hepatocellular carcinoma in infected individuals...
  51. MODELING VIRAL AND T LYMPHOCYTE DYNAMICS
    Alan S Perelson; Fiscal Year: 2011
    ..Infection by hepatitis C virus (HCV) and hepatitis B virus (HBV) continue to cause liver failure and hepatocellular carcinoma in infected individuals...
  52. Yujin Hoshida; Fiscal Year: 2016
    ..HCC develops from advanced fibrosis due to hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, or non-alcoholic fatty liver disease (NAFLD)...
  53. Charles R Rinaldo; Fiscal Year: 2016
    ..and lab testing of MSM in the Pittsburgh MACS, including T-cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and ..
  54. Mechanisms of Immune Evasion by Hepatitis C Virus
    Andrea L Cox; Fiscal Year: 2012
    ..vaccination and delivery of curative therapies for persistent infection, but these have been challenging for hepatitis B virus, human immunodeficiency virus, and HCV...
  55. Health Promotion Coaching/Vaccine for Homeless Parolees
    Adeline M Nyamathi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Homeless parolees are at high risk for Hepatitis B virus (HBV), Hepatitis C virus (HCV) and HIV infection due to high rates of injection drug use and unprotected sexual activity...
  56. HBV Prevention for Homeless at Risk for HBV/HCV/HIV
    Adeline M Nyamathi; Fiscal Year: 2013
    Abstract Homeless adults are at high risk for Hepatitis B virus (HBV), Hepatitis C virus (HCV) and HIV infection due to high rates of injection drug use and unprotected sexual activity...
  57. BRADLEY TOWNSEND KERRIDGE; Fiscal Year: 2015
    ..Research attention has focused on the relationship between IDU and HIV, Hepatitis B virus, Hepatitis C virus, and sexually transmitted infections (STIs), tending to overshadow the importance of ..
  58. Development of a rapid screening point-of-care test for HIV, HCV and HBV
    Stephen R Lee; Fiscal Year: 2012
    ..This test system will be capable of identifying patients infected by HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV) in a small drop of blood obtained by finger stick...
  59. ARON LUKACHER; Fiscal Year: 2015
    ..It has been stated that viruses are among the strongest carcinogens known. These viruses include hepatitis B virus, hepatitis C virus and certain human papillomaviruses...
  60. Elina I Zuniga; Fiscal Year: 2016
    ..HEALTH RELEVANCE: Viruses that cause chronic infections, including Human Immunodeficiency virus (HIV), Hepatitis B virus (HBV) and Hepatitis C virus (HCV), infect more than 500 million people worldwide and represent a major ..
  61. Kenneth E Sherman; Fiscal Year: 2016
    ..The etiologies of liver disease include hepatitis C virus (HCV) and hepatitis B virus (HBV) infection as well as drug-induced liver toxicity...
  62. LUMINESCENT ANTIVIRAL DRUG DISCOVERY ASSAY
    Kalvin Gregory; Fiscal Year: 2010
    ..Approximately 360 million people worldwide suffer from hepatitis B virus, the major cause of liver cancer...
  63. GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2016
    ..tests, from 28 weeks'gestation until two months postpartum to prevent perinatal transmission of hepatitis B virus (HBV)...
  64. Development of a DNA Vaccine for Chronic HBV Infection
    Claire Evans; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Acute hepatitis B virus (HBV) infection is generally self-limited...
  65. Hepatitis B virus immune escape mutants
    Shuping Tong; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Nearly 400 million people worldwide are chronically infected with hepatitis B virus (HBV) and are at risk for cirrhosis or liver cancer, which necessitates liver transplantation...
  66. An HBV polymerase RNA binding assay suitable for inhibitor screening
    Feng Cao; Fiscal Year: 2009
    b>Hepatitis B virus (HBV) is a hepatotropic DNA virus that replicates by reverse transcription. It chronically infects over 350 million people worldwide and causes 600,000 deaths annually...
  67. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The liver is also a target for persistent viral infections, such as chronic infections with the hepatitis B virus (HBV)...
  68. 2010 Molecular Biology of Hepatitis B Viruses Meeting
    Adam Zlotnick; Fiscal Year: 2010
    ..by applicant): Approximately 25% of the earth's population, 2 billion people, have been infected by Hepatitis B Virus (HBV). Approximately 360 million people suffer from chronic infection...
  69. HEPATITIS B VIRUS - CHRONIC HEPATITIS - LIVER CANCER
    DAVID SHAFRITZ; Fiscal Year: 1991
    Our overall goal is to study regulation of hepatitis B virus (HBV) gene expression and events in virus replication in human, animal model and cell culture systems and to investigate mechanisms whereby persistent infection with hepatitis ..
  70. PATHOBIOLOGY OF HEPATITIS B VIRUS
    ROBERT SCHLOEMER; Fiscal Year: 1990
    The role of components of hepatitis B virus (HBV) in the outcome of infection and in the pathogenesis of the resulting disease is unclear...
  71. HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMA
    BETTY SLAGLE; Fiscal Year: 1999
    Chronic infection with hepatitis B virus (HBV) is an important risk factor in the development of hepatocellular carcinoma (HCC)...
  72. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hepatitis B virus (HBV) remains a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV is a member of the hepadnavirus group, double-stranded DNA viruses...
  73. PATHOGENESIS, IMMUNODIAGNOSIS, AND THERAPY OF HCC
    Jack Wands; Fiscal Year: 1999
    ..During the previous grant period, we have shown that generation of hepatitis B virus (HBV) variants occurs during active replication and these molecular events may lead to viral persistence in ..
  74. VIRAL HEPATITIS IN CHILDREN OF INJECTION DRUG USERS
    Kathleen Schwarz; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Hepatitis B virus (HBV) and hepatitis C virus (HCV) are endemic among adult injection drug users (IDUs)...

Patents93

  1. MODIFIED HEPATITIS POST-TRANSCRIPTIONAL REGULATORY ELEMENTS
    Patent Number: WO2016115177-A1; Date:2016-07-21
  2. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
    Patent Number: KR1020160002974-A; Date:2016-01-08
  3. CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
    Patent Number: KR1020160003723-A; Date:2016-01-11
  4. Recombinant self-assembling protein comprising a target-specfic peptide and use thereof
    Patent Number: KR1020160061304-A; Date:2016-05-31
  5. CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
    Patent Number: JP2016526018-A; Date:2016-09-01
  6. REMODELING AND GLYCOCONJUGATION OF PEPTIDES
    Patent Number: JP2016037503-A; Date:2016-03-22
  7. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
    Patent Number: JP2016522683-A; Date:2016-08-04
  8. VACCINE
    Patent Number: WO2016034974-A1; Date:2016-03-10
  9. COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
    Patent Number: EP2992098-A2; Date:2016-03-09
  10. COMBINED TREATMENT WITH A TLR7 AGONIST AND AN HBV CAPSID ASSEMBLY INHIBITOR
    Patent Number: WO2016146598-A1; Date:2016-09-22
  11. A NOVEL HIGH-THROUGHPUT METHOD FOR QUANTIFICATION OF HBV CCCDNA FROM CELL LYSATE BY REAL-TIME PCR
    Patent Number: WO2016107833-A1; Date:2016-07-07
  12. VACCINES BASED ON HEPATITIS B CORE ANTIGENS
    Patent Number: WO2016087863-A1; Date:2016-06-09
  13. RECOMBINANT HBV CCCDNA, THE METHOD TO GENERATE THEREOF AND THE USE THEREOF
    Patent Number: WO2016120186-A1; Date:2016-08-04
  14. VACCINES BASED ON HEPATITIS B CORE ANTIGENS
    Patent Number: WO2016151337-A1; Date:2016-09-29
  15. VACCINE TARGETING IL-17A
    Patent Number: EP3088000-A1; Date:2016-11-02
  16. SPECIFIC VIRUS-LIKE PARTICLE-CPG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
    Patent Number: EP3079717-A1; Date:2016-10-19
  17. ANTIBODY DISPLAY
    Patent Number: JP2016528176-A; Date:2016-09-15
  18. Composition for treating HBV infection
    Patent Number: JP2016074707-A; Date:2016-05-12
  19. Disulfide Stabilized Polypeptides
    Patent Number: JP2016507520-A; Date:2016-03-10
  20. Methods for detecting hapatitis B virus surface gene non-sense muations
    Patent Number: KR1020150041637-A; Date:2015-04-16
  21. METHODS FOR DETECTING HEPATITIS B VIRUS SURFACE GENE NON-SENSE MUTATIONS
    Patent Number: EP2885433-A2; Date:2015-06-24
  22. Polypeptide Vaccine
    Patent Number: JP2014526462-A; Date:2014-10-06
  23. MULTIPLEX REAL TIME PCR TESTING KIT FOR THE SIMULTANEOUS DETECTION OF HEPATITIS VIRUS
    Patent Number: WO2014136124-A2; Date:2014-09-12
  24. DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE
    Patent Number: KR1020150070116-A; Date:2015-06-24
  25. NOVEL FUSION PROTEINS AND USE THEREOF FOR PREPARING HEPATITIS C VACCINES
    Patent Number: KR1020150085128-A; Date:2015-07-22
  26. DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE
    Patent Number: EP2891497-A1; Date:2015-07-08
  27. MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
    Patent Number: JP2014513954-A; Date:2014-06-19
  28. VACCINES BASED ON HEPATITIS B CORE ANTIGENS
    Patent Number: WO2015124919-A1; Date:2015-08-27
  29. HBV TREATMENT
    Patent Number: KR1020140071949-A; Date:2014-06-12
  30. Hepatitis b virus-derived cis-regulatory element and use thereof
    Patent Number: KR1020140044924-A; Date:2014-04-15
  31. DNA VACCINE
    Patent Number: KR1020140048119-A; Date:2014-04-23
  32. Composition for inhibiting the replication of hepatitis B virus
    Patent Number: KR1020140050243-A; Date:2014-04-29
  33. DNA VACCINE
    Patent Number: EP2698164-A1; Date:2014-02-19
  34. Composition of DNA vaccine for preventing and treating hepatitis B
    Patent Number: JP2014500875-A; Date:2014-01-16
  35. DNA vaccine comprising specific epitope in VEGF and/or angiopoietin-2
    Patent Number: WO2014034735-A; Date:2014-03-06
  36. DNA vaccine comprising specific epitope in apolipoprotein (a)
    Patent Number: JP2014060968-A; Date:2014-04-10
  37. Primer for amplifying hepatitis B virus DNA and method for detecting hepatitis B virus by use thereof
    Patent Number: JP2014140367-A; Date:2014-08-07
  38. Crystal of hepatitis B virus core fusion protein corresponding to octahedral particles
    Patent Number: JP2014212722-A; Date:2014-11-17
  39. Structure and Use of 5' Phosphate Oligonucleotides
    Patent Number: JP2014207906-A; Date:2014-11-06
  40. METHODS AND COMPOSITIONS FOR CONTROLLING ASSEMBLY OF VIRAL PROTEINS
    Patent Number: JP2014527072-A; Date:2014-10-09
  41. HBV-specific artificial DNA nuclease
    Patent Number: WO2014204014-A; Date:2014-12-24
  42. HBV-specific artificial DNA nuclease
    Patent Number: JP2015002723-A; Date:2015-01-08
  43. VIRAL VARIANTS AND METHODS FOR DETECTING SAME
    Patent Number: JP2015107127-A; Date:2015-06-11
  44. Vaccine targeting IL-17A
    Patent Number: WO2015099167-A; Date:2015-07-02
  45. An in vitro liver model containing hepatitis virus
    Patent Number: JP2015173635-A; Date:2015-10-05
  46. REMODELING AND GLYCOCONJUGATION OF PEPTIDES
    Patent Number: JP2014087370-A; Date:2014-05-15
  47. Molecular Antigen Array
    Patent Number: JP2015205881-A; Date:2015-11-19
  48. Conserved HBV and HCV Sequences Useful for Gene Silencing
    Patent Number: JP2015003913-A; Date:2015-01-08
  49. Hepatitis B virus like particle and method for a screening of drug for treating hepatitis B using the same
    Patent Number: WO2015133613-A; Date:2015-09-11
  50. METHODS AND COMPOSITIONS FOR CONTROLLING ASSEMBLY OF VIRAL PROTEINS
    Patent Number: EP2747774-A2; Date:2014-07-02
  51. DETECTION OF NUCLEIC ACIDS USING UNMODIFIED GOLD NANOPARTICLES
    Patent Number: EP2694685-A1; Date:2014-02-12
  52. Promoters for regulated gene expression
    Patent Number: WO0194600-A2; Date:2001-12-13
  53. Drugs for cancer therapy and process for preparing the same
    Patent Number: JP2006265152-A; Date:2006-10-05
  54. STABILIZED IMMUNOGENIC HBc CHIMER PARTICLES
    Patent Number: JP2006509026-A; Date:2006-03-16
  55. Hybridization assay for amplified nucleic acid by using a nucleic acid presipitant
    Patent Number: JP2004141159-A; Date:2004-05-20
  56. A stabilization method and a preservation method for a reagent for nucleic acid amplification or detection reaction
    Patent Number: JP2007228977-A; Date:2007-09-13
  57. HEPATITIS B VIRUS TREATMENT
    Patent Number: JP2005505238-A; Date:2005-02-24
  58. Method for synthesizing nucleic acid
    Patent Number: WO2000028082-A; Date:2000-05-18
  59. Regulatory sequences and expression cassettes for yeasts
    Patent Number: WO0120005-A1; Date:2001-03-22
  60. IMMUNOGENIC HBc CHIMER PARTICLES HAVING ENHANCED STABILITY
    Patent Number: JP2012139237-A; Date:2012-07-26
  61. PRODUCTION OF HEPATITIS B SURFACE ANTIGEN
    Patent Number: JP1987091196-A; Date:1987-04-25
  62. ANTIGEN FUSED PROTEIN FROM DUCK HEPATITIS VIRUS AND HUMAN HEPATITIS VIRUS AND ITS PRODUCTION
    Patent Number: JP1995252300-A; Date:1995-10-03
  63. Composition for treating HBV infection
    Patent Number: JP2013501038-A; Date:2013-01-10
  64. Hepatitis b core antigen fusion proteins
    Patent Number: WO0177158-A1; Date:2001-10-18
  65. Molecular Antigen Array
    Patent Number: JP2004522736-A; Date:2004-07-29
  66. Novel surface protein (HBsAg) variant of the Hepatitis B virus
    Patent Number: JP2007536897-A; Date:2007-12-20
  67. RIBOZYME AMPLIFIED DIAGNOSTICS
    Patent Number: JP2004000281-A; Date:2004-01-08
  68. Conserved HBV and HCV Sequences Useful for Gene Silencing
    Patent Number: JP2007503474-A; Date:2007-02-22
  69. Nucleic acid based detection process and uses thereof
    Patent Number: WO2009087687-A1; Date:2009-07-16
  70. A hepatitis B virus (subtype ayw) surface antigen variant
    Patent Number: EP1142906-A1; Date:2001-10-10
  71. Method for detection of hepatitis nucleic acid and uses thereof
    Patent Number: WO2009087685-A2; Date:2009-07-16
  72. OLIGONUCLEOTIDE MEDIATED INHIBITION OF HEPATITIS B VIRUS AND HEPATITIS C VIRUS REPLICATION
    Patent Number: JP2004532022-A; Date:2004-10-21
  73. Influenza Virus Vaccine Composition and Methods of Use
    Patent Number: JP2008505660-A; Date:2008-02-28
  74. Monitoring hybridization during pcr
    Patent Number: EP1179600-A1; Date:2002-02-13
  75. Method for amplifying nucleic acid in which double-stranded nucleic acid is a template
    Patent Number: WO2001077317-A; Date:2001-10-18
  76. Method for determining subtype of Hepatitis B virus genotype B
    Patent Number: JP2005269994-A; Date:2005-10-06
  77. A Hepatitis B Virus Surface Antigen Mutant And Methods Of Detection Thereof
    Patent Number: JP2004532019-A; Date:2004-10-21
  78. Transdermal formulations containing hepatitis c Virus immunogens
    Patent Number: WO2008004992-A2; Date:2008-01-10
  79. Molecular antigen arrays and vaccines
    Patent Number: WO0185208-A2; Date:2001-11-15
  80. Method for detecting target nucleotide sequence and probes therefor
    Patent Number: JP2005118031-A; Date:2005-05-12
  81. HBV VARIANTS DETECTION AND APPLICATION
    Patent Number: KR1020130049210-A; Date:2013-05-13
  82. Hepatitis B virus (HBV) variants
    Patent Number: EP2360257-A2; Date:2011-08-24
  83. Therapeutic agent for hemophilia and therapeutic method for hemophilia using the same
    Patent Number: WO2004082720-A; Date:2004-09-30
  84. Compositions and Methods for Detecting Hepatitis B Virus
    Patent Number: JP2011019528-A; Date:2011-02-03
  85. Recombinant DNA molecules and their method of production
    Patent Number: EP0374869-A1; Date:1990-06-27
  86. Oligonucleotide Probes and Primers for Detection of Hepatitis B Virus
    Patent Number: JP2012517804-A; Date:2012-08-09
  87. Pseudotyping of foamy viruses
    Patent Number: EP2583974-A1; Date:2013-04-24
  88. No title supplied
    Patent Number: WO2007003775-A1; Date:2007-01-11
  89. method of inhibition of self-annealing
    Patent Number: JP2007282512-A; Date:2007-11-01
  90. Method for determining subtype of Hepatitis B virus genotype A
    Patent Number: JP2005270031-A; Date:2005-10-06
  91. Optimized Multi-epitope Constructs and Uses Thereof
    Patent Number: JP2006501827-A; Date:2006-01-19
  92. Macrocapsule solution and method for expression enzyme or protein
    Patent Number: JP2006213678-A; Date:2006-08-17
  93. Method for identifying subtype of genotype C of hepatitis B virus and kit therefor
    Patent Number: JP2007006734-A; Date:2007-01-18