Newcastle disease virus B1

Summary

Alias: Newcastle disease virus strain B1

Top Publications

  1. doi Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
    Ryota Tsunekuni
    Avian Influenza Research Centre, Kyoto Sangyo University, Kamigamo Motoyama, Kyoto 603 8555, Japan
    Virus Genes 40:252-5. 2010
  2. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
  3. pmc Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:2501-11. 2012
  4. pmc Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
    Ingrid Cornax
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 94:1189-94. 2013
  5. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
  6. pmc Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e74022. 2013
  7. doi HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression
    R S Rajmani
    Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
    Arch Virol 161:2395-405. 2016
  8. doi Identification and functional analysis of phosphorylation in Newcastle disease virus phosphoprotein
    Xusheng Qiu
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, People s Republic of China
    Arch Virol 161:2103-16. 2016
  9. doi HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism
    Wei Zhao
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi, China
    Virus Genes 47:27-33. 2013
  10. doi HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
    R S Rajmani
    Molecular Biology Laboratory, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, 243122, India
    Appl Biochem Biotechnol 177:940-56. 2015

Patents

  1. Virus-Like Particles as Vaccines for Paramyxovirus
  2. Virus-Like Particles as Vaccines for Paramyxovirus

Scientific Experts

  • Zhuo ming Qin
  • Takashi Kimura
  • Zhiqiang Duan
  • Siba K Samal
  • Peter L Collins
  • R S Rajmani
  • Lori W McGinnes
  • Trudy G Morrison
  • Shin Hee Kim
  • Xiufan Liu
  • Shunlin Hu
  • Wei Zhao
  • Sweety Samal
  • Sunil K Khattar
  • Jian Chen
  • Haixu Xu
  • Anandan Paldurai
  • Surbhi Jain
  • Qingzhong Yu
  • Ashok K Tiwari
  • Uttara Chaturvedi
  • Aparna Talekar
  • Matteo Porotto
  • Anne M Mirza
  • Ronald M Iorio
  • Xusheng Qiu
  • Shishir Kumar Gupta
  • Ravi Kumar Gandham
  • Prafull Kumar Singh
  • A P Sahoo
  • Chengxi Sun
  • Huimou Liu
  • Bin Lin
  • Chandra Shekhar Kumar
  • Sayantan Bose
  • Zhiyu Wang
  • Jie Zhu
  • Sa Xiao
  • Qunhui Li
  • Liang He
  • Fu Lu Chu
  • Laszlo Zsak
  • Ingrid Cornax
  • Sachin Kumar
  • Anne Moscona
  • Michihito Sasaki
  • Robert A Lamb
  • Theodore S Jardetzky
  • Anthony J Battisti
  • Kathryn A Gravel
  • Min Gu
  • Paul J Mahon
  • Ryota Tsunekuni
  • Juan Ayllon
  • Hong Sui
  • Kurt Swanson
  • Judith G Alamares
  • L Wang
  • Mostafa Jarahian
  • Yong Wang
  • P V Ravindra
  • Jason P Laliberte
  • Yan Peng Tan
  • L W McGinnes
  • Ying chun Sun
  • E Kusumaningtyas
  • Yingjie Sun
  • Chan Ding
  • Shengqing Yu
  • Luna Dong
  • Chunchun Meng
  • Lei Tan
  • Junqing Wang
  • Cuiping Song
  • Yuan Zhan
  • Rajiv Kumar
  • Fulu Chu
  • Yuzhen Chen
  • Guijie Ren
  • Shikha Saxena
  • Hongling Wen
  • Yanyan Song
  • Yuyang Wang
  • Juan Li
  • Albert S Song
  • Carlos Estevez
  • Yan Yan Song
  • Yan Zhang
  • Senthilkumar Palaniyandi
  • Hong Ling Wen

Detail Information

Publications45

  1. doi Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
    Ryota Tsunekuni
    Avian Influenza Research Centre, Kyoto Sangyo University, Kamigamo Motoyama, Kyoto 603 8555, Japan
    Virus Genes 40:252-5. 2010
    ..These results suggest that in addition to the F cleavage site sequence, these two amino acids in HN protein are also related to the pathogenicity of NDV in chickens...
  2. pmc A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Virol 83:7779-82. 2009
    ..While most of the mutations had surprisingly little effect, mutation at conserved residue Y526 reduced the neuraminidase, receptor binding, and fusion activities and attenuated viral virulence in eggs and young birds...
  3. pmc Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 86:2501-11. 2012
    ..These results illustrate the effects of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and HR2 coordinately downregulate viral fusion and virulence...
  4. pmc Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
    Ingrid Cornax
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 94:1189-94. 2013
    ..These results indicate that the F and HN proteins are determinants of NDV macrophage host range. This represents the first description of productive NDV infection in macrophages...
  5. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
    ..We conclude that these wild-type residues in the NDV F CT have an effect on regulating F protein biological functions and thus modulating viral replication and pathogenesis. ..
  6. pmc Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e74022. 2013
    ..Our findings showed that genotype-matched vaccines can provide protection to chickens by efficiently preventing spread of virus, primarily due to the F protein. ..
  7. doi HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-α-induced apoptosis by downregulating NF-κB expression
    R S Rajmani
    Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
    Arch Virol 161:2395-405. 2016
    ..The results of the study provide a mechanistic insight into the apoptotic action of HN protein along with TNF-α, which could be valuable in treating tumor types that are naturally resistant to TNF-α. ..
  8. doi Identification and functional analysis of phosphorylation in Newcastle disease virus phosphoprotein
    Xusheng Qiu
    Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, People s Republic of China
    Arch Virol 161:2103-16. 2016
    ..This study sheds light on the mechanism by which P protein phosphorylation affects NDV replication and transcription. ..
  9. doi HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism
    Wei Zhao
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi, China
    Virus Genes 47:27-33. 2013
    ..These results demonstrated that the HN protein C-terminal extension of NDV is not the determinant of the virus enteric tropism. ..
  10. doi HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway
    R S Rajmani
    Molecular Biology Laboratory, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, 243122, India
    Appl Biochem Biotechnol 177:940-56. 2015
    ..The results of our study provide an insight into the mechanism through which HN induces apoptosis...
  11. doi Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process
    Chengxi Sun
    Department of Virology, School of Public Health, Shandong University
    Biosci Trends 9:56-64. 2015
    ..It was also proven that the headless HN of NDV could promote the fusion event mediated by F. Thus, it revealed a novel mechanism in F activation of NDV. ..
  12. doi Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence
    Wei Zhao
    Southeast Poultry Research Laboratory, Agricultural Research Services, United States Department of Agriculture, 934 College Station Road, Athens, GA, 30605, USA
    Virus Genes 47:498-504. 2013
    ..These results suggest that the HN protein C-terminal extension may contribute to the reduced virulence in some low virulence NDV strains. ..
  13. pmc Measles virus fusion machinery activated by sialic acid binding globular domain
    Aparna Talekar
    Departments of Pediatrics
    J Virol 87:13619-27. 2013
    ....
  14. ncbi [Matrix protein of Newcastle disease virus interacts with avian nucleophosmin B23. 1 in HEK-293T cells]
    Zhiqiang Duan
    Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou 225009, China
    Wei Sheng Wu Xue Bao 53:730-6. 2013
    ..OBJECIVE: To identify the interaction between Newcastle disease virus (NDV) matrix (M) protein and avian nucleophosmin B23. 1 in HEK-293T cells...
  15. pmc Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA
    J Gen Virol 95:331-6. 2014
    ..These results indicate that this attenuating mechanism in avirulent strains such as Ulster can be applied directly to a highly virulent strain recently in circulation. ..
  16. pmc Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells
    Sayantan Bose
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA
    J Virol 88:3925-41. 2014
    ....
  17. doi A single amino acid mutation, R42A, in the Newcastle disease virus matrix protein abrogates its nuclear localization and attenuates viral replication and pathogenicity
    Zhiqiang Duan
    College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China
    J Gen Virol 95:1067-73. 2014
    ..This is the first report to show that a basic residue mutation in the NDV M protein abrogates its nuclear localization and attenuates viral replication and pathogenicity. ..
  18. doi The nucleolar phosphoprotein B23 targets Newcastle disease virus matrix protein to the nucleoli and facilitates viral replication
    Zhiqiang Duan
    Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China Ministry of Educational Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou 225009, China
    Virology 452:212-22. 2014
    ..Collectively, we show that B23 facilitates NDV replication by targeting M to the nucleolus, demonstrating for the first time a direct role for nucleolar protein B23 in a paramyxovirus replication process. ..
  19. pmc Species based synonymous codon usage in fusion protein gene of Newcastle disease virus
    Chandra Shekhar Kumar
    Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
    PLoS ONE 9:e114754. 2014
    ..The present study provides a basic understanding of the mechanism involved in codon usage among species. ..
  20. pmc A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation
    Anne M Mirza
    Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 87:8813-5. 2013
    ..Here, we demonstrate that a nearby L97A substitution, though previously shown to block fusion, allows efficient HN-F complex formation and likely acts by preventing changes in the HN stalk required for triggering of the bound F protein. ..
  21. pmc Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion
    Paul J Mahon
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 85:12079-82. 2011
    ....
  22. pmc Molecular detection of a novel paramyxovirus in fruit bats from Indonesia
    Michihito Sasaki
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Virol J 9:240. 2012
    ..Fruit bats are known to harbor zoonotic paramyxoviruses including Nipah, Hendra, and Menangle viruses. The aim of this study was to detect the presence of paramyxovirus RNA in fruit bats from Indonesia...
  23. doi 'a'-Position-mutated and G4-mutated hemagglutinin-neuraminidase proteins of Newcastle disease virus impair fusion and hemagglutinin-neuraminidase-fusion interaction by different mechanisms
    Fu Lu Chu
    Department of Virology, School of Public Health, Shandong University, Jinan 250012, China
    Intervirology 56:27-36. 2013
    ..To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction...
  24. pmc Structure and assembly of a paramyxovirus matrix protein
    Anthony J Battisti
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2032, USA
    Proc Natl Acad Sci U S A 109:13996-4000. 2012
    ..Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly...
  25. pmc The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion
    Matteo Porotto
    Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA
    J Virol 86:5730-41. 2012
    ..We suggest a general model for paramyxovirus fusion activation in which receptor engagement at site II plays an active role in F activation...
  26. pmc Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy
    Min Gu
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China
    Virol J 8:150. 2011
    ....
  27. pmc Local immunity against Newcastle disease virus in the newly hatched chicken's respiratory tract
    M Malkinson
    Infect Immun 16:587-92. 1977
    Inoculation of 200 mean egg infectious doses (EID(50)) of lentogenic Newcastle disease virus strain B1 (NDV-B1) into the air sac of 4-day-old specific-pathogen-free chicks provided significant protection against challenge of the air sac ..
  28. ncbi Existence of two forms of L protein of Newcastle disease virus isolates due to a compensatory mutation in Domain V
    E Kusumaningtyas
    Department of Biochemistry and Microbiology, Faculty of Science and Environmental Studies, Serdang, Malaysia
    Arch Virol 149:1859-65. 2004
    ..This compensatory mutation does not correlate with the pathogenicity of the viral strains but it may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses...
  29. ncbi [Induction of apoptosis in human hepatoma cell line SMMC7721 by Newcastle disease virus HN gene]
    Ying chun Sun
    Genetic Engineering Labotory of PLA, Academy of Military Medical Sciences, Changchun 130062, China
    Zhonghua Zhong Liu Za Zhi 27:279-82. 2005
    ..To investigate the mechanisms of apoptosis induced in human hepatoma cell line SMMC7721 by plasmid pVHN constructed with Newcastle disease virus (NDV) HN gene...
  30. ncbi Purification of recombinant nucleocapsid protein of Newcastle disease virus from unclarified feedstock using expanded bed adsorption chromatography
    Yan Peng Tan
    Department of Chemical and Environmental Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Protein Expr Purif 46:114-21. 2006
    ..The results of the present study show that the IMA-EBAC developed could be used to combine the clarification, concentration and initial purification steps into a single-step operation...
  31. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006
    ..Furthermore, the results show that not only receptor binding but also F protein cleavage are necessary for disassociation of the HN and F protein-containing complexes...
  32. ncbi [Newcastle disease virus heredity mutation and correlation of HN and F gene]
    Zhuo ming Qin
    College of Animal Science and Technology, Shandong Agriculture University, Tai an 271018, China
    Wei Sheng Wu Xue Bao 46:227-32. 2006
    ..The sequences of HN gene in Chinese isolates had an identity of more than 97%. But there was only 79.2% - 80.7% in HN nucleotide homology among the Chinese isolates and La Sota (vaccine)...
  33. pmc Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:2328-39. 2007
    ..In the presence of HN protein, only the reduced form may proceed to refold into additional intermediates, leading to the fusion of membranes...
  34. pmc Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity
    Jason P Laliberte
    Department of Molecular Genetics and Microbiology, Room S5 250, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:10636-48. 2007
    ....
  35. doi HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells
    P V Ravindra
    Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, India
    Arch Virol 153:749-54. 2008
    ..Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells...
  36. ncbi [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]
    Zhuoming Qin
    Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    Wei Sheng Wu Xue Bao 48:226-33. 2008
    ..05, r = 0.20 or 0.19) with the F gene, and non-correlated with 374 nt segment. This implied that the genetic mutations of HN resulted in antigenic variations of these viruses and the search for new vaccines would be necessary...
  37. ncbi [Evaluation of Newcastle disease virus with derivated hemagglutinin-neuraminidase gene of mesogenic strain]
    Yong Wang
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
    Wei Sheng Wu Xue Bao 48:638-43. 2008
    ..To understand the exact contribution of the HN gene to NDV pathogenecity, a reverse genetics system was developed using the lentogenic NDV LaSota strain ...
  38. pmc Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 82:12039-48. 2008
    ..These results suggest that isomerases belonging to the PDI family catalyze the production of free thiols in F protein, and free thiols in F protein facilitate membrane fusion mediated by F protein...
  39. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  40. ncbi Expression of Newcastle disease virus (NDV) M protein from a recombinant plasmid prolongs the survival of NDV-infected chicken embryos and enhances the virus replication
    L Wang
    State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing, PR China
    Acta Virol 53:105-10. 2009
    ..These data indicated that the expression of M protein in the NDV-infected chicken embryos primarily prolonged their survival and consequently enhanced virus replication...
  41. pmc The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties
    Judith G Alamares
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Virus Res 147:153-7. 2010
    ..Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN-antagonistic activity between the two V proteins...
  42. pmc Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype
    Juan Ayllon
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental Lab 112, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
    J Virol 84:1066-75. 2010
    ..The data are discussed in terms of alterations of the refolding pathway and/or the stability of the prefusion and fusion conformations...
  43. doi The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting
    Hong Sui
    Medical Department, The Tumor Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang, China
    Cancer Immunol Immunother 59:989-99. 2010
    ..A DNA vaccine expressing the major immunogenic hemagglutinin-neuraminidase (HN) protein of this virus has shown promising results as an immunotherapeutic agent...
  44. pmc Structure of the Newcastle disease virus F protein in the post-fusion conformation
    Kurt Swanson
    Howard Hughes Medical Institute, USA
    Virology 402:372-9. 2010
    ..Electrostatic and temperature factor analysis of the F structures points to regions of these proteins that may be functionally important in their membrane fusion activity...
  45. pmc The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein
    Kathryn A Gravel
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 85:3486-97. 2011
    ..These results show that the specific sequence of the TM domain of the NDV F protein is important for the conformation of the preactivation form of the ectodomain, the interactions of the protein with HN protein, and fusion activity...

Patents2

  1. Virus-Like Particles as Vaccines for Paramyxovirus
    Patent Number: JP2013176375-A; Date:2013-09-09
  2. Virus-Like Particles as Vaccines for Paramyxovirus
    Patent Number: JP2009502204-A; Date:2009-01-29