Newcastle disease virus B1

Summary

Alias: Newcastle disease virus strain B1

Top Publications

  1. Tsunekuni R, Ito H, Otsuki K, Kida H, Ito T. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants. Virus Genes. 2010;40:252-5 pubmed publisher
    ..These results suggest that in addition to the F cleavage site sequence, these two amino acids in HN protein are also related to the pathogenicity of NDV in chickens...
  2. Khattar S, Yan Y, Panda A, Collins P, Samal S. A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity. J Virol. 2009;83:7779-82 pubmed publisher
    ..While most of the mutations had surprisingly little effect, mutation at conserved residue Y526 reduced the neuraminidase, receptor binding, and fusion activities and attenuated viral virulence in eggs and young birds...
  3. Samal S, Khattar S, Kumar S, Collins P, Samal S. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity. J Virol. 2012;86:2501-11 pubmed publisher
    ..These results illustrate the effects of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and HR2 coordinately downregulate viral fusion and virulence. ..
  4. Cornax I, Diel D, Rue C, Estevez C, Yu Q, Miller P, et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol. 2013;94:1189-1194 pubmed publisher
    ..These results indicate that the F and HN proteins are determinants of NDV macrophage host range. This represents the first description of productive NDV infection in macrophages. ..
  5. McGinnes L, Morrison T. Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes. J Virol. 2006;80:2894-903 pubmed publisher
    ..Furthermore, the results show that not only receptor binding but also F protein cleavage are necessary for disassociation of the HN and F protein-containing complexes...
  6. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    ..Our findings showed that genotype-matched vaccines can provide protection to chickens by efficiently preventing spread of virus, primarily due to the F protein...
  7. Battisti A, Meng G, Winkler D, McGinnes L, Plevka P, Steven A, et al. Structure and assembly of a paramyxovirus matrix protein. Proc Natl Acad Sci U S A. 2012;109:13996-4000 pubmed publisher
    ..Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly...
  8. Porotto M, Salah Z, Devito I, Talekar A, Palmer S, Xu R, et al. The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion. J Virol. 2012;86:5730-41 pubmed publisher
    ..We suggest a general model for paramyxovirus fusion activation in which receptor engagement at site II plays an active role in F activation...
  9. Mahon P, Mirza A, Iorio R. Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion. J Virol. 2011;85:12079-82 pubmed publisher
    ....
  10. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    ..These results show that the specific sequence of the TM domain of the NDV F protein is important for the conformation of the preactivation form of the ectodomain, the interactions of the protein with HN protein, and fusion activity...

Scientific Experts

Detail Information

Publications28

  1. Tsunekuni R, Ito H, Otsuki K, Kida H, Ito T. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants. Virus Genes. 2010;40:252-5 pubmed publisher
    ..These results suggest that in addition to the F cleavage site sequence, these two amino acids in HN protein are also related to the pathogenicity of NDV in chickens...
  2. Khattar S, Yan Y, Panda A, Collins P, Samal S. A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity. J Virol. 2009;83:7779-82 pubmed publisher
    ..While most of the mutations had surprisingly little effect, mutation at conserved residue Y526 reduced the neuraminidase, receptor binding, and fusion activities and attenuated viral virulence in eggs and young birds...
  3. Samal S, Khattar S, Kumar S, Collins P, Samal S. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity. J Virol. 2012;86:2501-11 pubmed publisher
    ..These results illustrate the effects of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and HR2 coordinately downregulate viral fusion and virulence. ..
  4. Cornax I, Diel D, Rue C, Estevez C, Yu Q, Miller P, et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol. 2013;94:1189-1194 pubmed publisher
    ..These results indicate that the F and HN proteins are determinants of NDV macrophage host range. This represents the first description of productive NDV infection in macrophages. ..
  5. McGinnes L, Morrison T. Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes. J Virol. 2006;80:2894-903 pubmed publisher
    ..Furthermore, the results show that not only receptor binding but also F protein cleavage are necessary for disassociation of the HN and F protein-containing complexes...
  6. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    ..Our findings showed that genotype-matched vaccines can provide protection to chickens by efficiently preventing spread of virus, primarily due to the F protein...
  7. Battisti A, Meng G, Winkler D, McGinnes L, Plevka P, Steven A, et al. Structure and assembly of a paramyxovirus matrix protein. Proc Natl Acad Sci U S A. 2012;109:13996-4000 pubmed publisher
    ..Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly...
  8. Porotto M, Salah Z, Devito I, Talekar A, Palmer S, Xu R, et al. The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion. J Virol. 2012;86:5730-41 pubmed publisher
    ..We suggest a general model for paramyxovirus fusion activation in which receptor engagement at site II plays an active role in F activation...
  9. Mahon P, Mirza A, Iorio R. Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion. J Virol. 2011;85:12079-82 pubmed publisher
    ....
  10. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    ..These results show that the specific sequence of the TM domain of the NDV F protein is important for the conformation of the preactivation form of the ectodomain, the interactions of the protein with HN protein, and fusion activity...
  11. Swanson K, Wen X, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010;402:372-9 pubmed publisher
    ..Electrostatic and temperature factor analysis of the F structures points to regions of these proteins that may be functionally important in their membrane fusion activity...
  12. Sui H, Bai Y, Wang K, Li X, Song C, Fu F, et al. The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting. Cancer Immunol Immunother. 2010;59:989-99 pubmed publisher
    ..The membrane-anchored form of the HN protein appears to be an ideal candidate to develop as an immunotherapeutic agent for NSCLC...
  13. Jarahian M, Watzl C, Fournier P, Arnold A, Djandji D, Zahedi S, et al. Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase. J Virol. 2009;83:8108-21 pubmed publisher
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  14. Jain S, McGinnes L, Morrison T. Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2008;82:12039-48 pubmed publisher
    ..These results suggest that isomerases belonging to the PDI family catalyze the production of free thiols in F protein, and free thiols in F protein facilitate membrane fusion mediated by F protein...
  15. Qin Z, Xu H, Ouyang W, Wang Y, Wang L, Yuan X, et al. [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]. Wei Sheng Wu Xue Bao. 2008;48:226-33 pubmed
    ..05, r = 0.20 or 0.19) with the F gene, and non-correlated with 374 nt segment. This implied that the genetic mutations of HN resulted in antigenic variations of these viruses and the search for new vaccines would be necessary...
  16. Ravindra P, Tiwari A, Sharma B, Rajawat Y, Ratta B, Palia S, et al. HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells. Arch Virol. 2008;153:749-54 pubmed publisher
    ..Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells...
  17. Laliberte J, McGinnes L, Morrison T. Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity. J Virol. 2007;81:10636-48 pubmed publisher
    ....
  18. Jain S, McGinnes L, Morrison T. Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2007;81:2328-39 pubmed publisher
    ..In the presence of HN protein, only the reduced form may proceed to refold into additional intermediates, leading to the fusion of membranes...
  19. Sun Y, Jin N, Mi Z, Li X, Lian H, Li P. [Induction of apoptosis in human hepatoma cell line SMMC7721 by Newcastle disease virus HN gene]. Zhonghua Zhong Liu Za Zhi. 2005;27:279-82 pubmed
    ..Significant apoptosis in SMMC7721 cells can be induced by NDV HN gene. Apoptosis may be resulted from the decrease of mitochondrial trans-membrane potential and activation of Caspase-3...
  20. Ayll n J, Villar E, Mu oz Barroso I. Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype. J Virol. 2010;84:1066-75 pubmed publisher
    ..The data are discussed in terms of alterations of the refolding pathway and/or the stability of the prefusion and fusion conformations...
  21. Alamares J, Elankumaran S, Samal S, Iorio R. The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties. Virus Res. 2010;147:153-7 pubmed publisher
    ..Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN-antagonistic activity between the two V proteins...
  22. Mirza A, Iorio R. A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation. J Virol. 2013;87:8813-5 pubmed publisher
    ..Here, we demonstrate that a nearby L97A substitution, though previously shown to block fusion, allows efficient HN-F complex formation and likely acts by preventing changes in the HN stalk required for triggering of the bound F protein...
  23. Bose S, Song A, Jardetzky T, Lamb R. Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells. J Virol. 2014;88:3925-41 pubmed publisher
    ....
  24. Sasaki M, Setiyono A, Handharyani E, Rahmadani I, Taha S, Adiani S, et al. Molecular detection of a novel paramyxovirus in fruit bats from Indonesia. Virol J. 2012;9:240 pubmed publisher
    ..Phylogenetic analysis showed that these virus sequences were related to henipavirus or rubulavirus. This study indicates the presence of novel paramyxoviruses among fruit bat populations in Indonesia...
  25. Talekar A, Moscona A, Porotto M. Measles virus fusion machinery activated by sialic acid binding globular domain. J Virol. 2013;87:13619-27 pubmed publisher
    ....
  26. Pegg C, Hoogland C, Gorman J. Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase. Glycoconj J. 2017;34:181-197 pubmed publisher
    ....
  27. Sun J, Han Z, Qi T, Zhao R, Liu S. Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein. J Biol Chem. 2017;292:20141-20161 pubmed publisher
    ..Collectively, our results indicate that CG-1B has anti-NDV activity by binding to N-glycans on HN glycoprotein. ..