Human immunodeficiency virus 1

Summary

Alias: human immunodeficiency virus 1 HIV-1, human immunodeficiency virus-1 HIV-1, human immunodeficiency virus type-1 HIV-1, human immunodeficiency virus type I HIV-1, human immunodeficiency virus type 1, HIV-1, human immunodeficiency virus type 1 HIV1, human immunodeficiency virus type 1 HIV-1, human immunodeficiency virus type 1 HIV 1, human immunodeficiency virus HIV-1, Human immunodeficiency virus type 1, HIV-1, LAV-1, HIV1, HIV, human immunodeficiency virus type 1 ,HIV-1, Human immunodeficiencey virus type 1, Human immundeficiency virus type 1, AIDS virus

Top Publications

  1. Meehan A, Saenz D, Guevera R, Morrison J, Peretz M, Fadel H, et al. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014;10:e1003969 pubmed publisher
    ..RNAi screens have implicated Nup358 in the HIV-1 life cycle...
  2. Alvarez R, Hamlin R, Monroe A, Moldt B, Hotta M, Rodriguez Caprio G, et al. HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol. 2014;88:6031-46 pubmed publisher
    ..factor tetherin retains virus particles on the surfaces of cells infected with vpu-deficient human immunodeficiency virus type 1 (HIV-1)...
  3. Ku P, Bendjennat M, Ballew J, Landesman M, Saffarian S. ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly. PLoS ONE. 2014;9:e96950 pubmed publisher
    Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of Human Immunodeficiency Virus 1 (HIV-1)...
  4. Chikere K, Webb N, Chou T, Borm K, Sterjovski J, Gorry P, et al. Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies. Retrovirology. 2014;11:48 pubmed publisher
    The efficiency of CD4/CCR5 mediated HIV-1 entry has important implications for pathogenesis and transmission...
  5. Bai Y, Tambe A, Zhou K, Doudna J. RNA-guided assembly of Rev-RRE nuclear export complexes. elife. 2014;3:e03656 pubmed publisher
    b>HIV replication requires nuclear export of unspliced and singly spliced viral transcripts...
  6. Flegler A, Cianci G, Hope T. CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS ONE. 2014;9:e89056 pubmed publisher
    CCR5 acts as the principal coreceptor during HIV-1 transmission and early stages of infection...
  7. Bleck M, Itano M, Johnson D, Thomas V, North A, Bieniasz P, et al. Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding. Proc Natl Acad Sci U S A. 2014;111:12211-6 pubmed publisher
    b>HIV-1 virions assemble at the plasma membrane of mammalian cells and recruit the endosomal sorting complex required for transport (ESCRT) machinery to enable particle release...
  8. Valiente Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi I, Bernard N, et al. eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection. Nat Commun. 2014;5:4819 pubmed publisher
    ..Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2? phosphorylation and even when SG assembly is forced by ..
  9. Yasmeen A, Ringe R, Derking R, Cupo A, Julien J, Burton D, et al. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology. 2014;11:41 pubmed publisher
    The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs)...
  10. Hatziioannou T, Del Prete G, Keele B, Estes J, McNatt M, Bitzegeio J, et al. HIV-1-induced AIDS in monkeys. Science. 2014;344:1401-5 pubmed publisher
    ..To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8(+) cells ..

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Detail Information

Publications153 found, 100 shown here

  1. Meehan A, Saenz D, Guevera R, Morrison J, Peretz M, Fadel H, et al. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014;10:e1003969 pubmed publisher
    ..RNAi screens have implicated Nup358 in the HIV-1 life cycle...
  2. Alvarez R, Hamlin R, Monroe A, Moldt B, Hotta M, Rodriguez Caprio G, et al. HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol. 2014;88:6031-46 pubmed publisher
    ..factor tetherin retains virus particles on the surfaces of cells infected with vpu-deficient human immunodeficiency virus type 1 (HIV-1)...
  3. Ku P, Bendjennat M, Ballew J, Landesman M, Saffarian S. ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly. PLoS ONE. 2014;9:e96950 pubmed publisher
    Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of Human Immunodeficiency Virus 1 (HIV-1)...
  4. Chikere K, Webb N, Chou T, Borm K, Sterjovski J, Gorry P, et al. Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies. Retrovirology. 2014;11:48 pubmed publisher
    The efficiency of CD4/CCR5 mediated HIV-1 entry has important implications for pathogenesis and transmission...
  5. Bai Y, Tambe A, Zhou K, Doudna J. RNA-guided assembly of Rev-RRE nuclear export complexes. elife. 2014;3:e03656 pubmed publisher
    b>HIV replication requires nuclear export of unspliced and singly spliced viral transcripts...
  6. Flegler A, Cianci G, Hope T. CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS ONE. 2014;9:e89056 pubmed publisher
    CCR5 acts as the principal coreceptor during HIV-1 transmission and early stages of infection...
  7. Bleck M, Itano M, Johnson D, Thomas V, North A, Bieniasz P, et al. Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding. Proc Natl Acad Sci U S A. 2014;111:12211-6 pubmed publisher
    b>HIV-1 virions assemble at the plasma membrane of mammalian cells and recruit the endosomal sorting complex required for transport (ESCRT) machinery to enable particle release...
  8. Valiente Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi I, Bernard N, et al. eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection. Nat Commun. 2014;5:4819 pubmed publisher
    ..Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2? phosphorylation and even when SG assembly is forced by ..
  9. Yasmeen A, Ringe R, Derking R, Cupo A, Julien J, Burton D, et al. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology. 2014;11:41 pubmed publisher
    The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs)...
  10. Hatziioannou T, Del Prete G, Keele B, Estes J, McNatt M, Bitzegeio J, et al. HIV-1-induced AIDS in monkeys. Science. 2014;344:1401-5 pubmed publisher
    ..To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8(+) cells ..
  11. Swartz T, Esposito A, Durham N, Hartmann B, Chen B. P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection. J Virol. 2014;88:11504-15 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1) infection is chronic and presently still incurable...
  12. Amorim N, da Silva E, de Castro R, da Silva Januário M, Mendonça L, Bonifacino J, et al. Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem. 2014;289:27744-56 pubmed publisher
    ..Together, our results indicate that Alix functions as an adaptor for the ESCRT-dependent, ubiquitin-independent targeting of CD4 to the MVB pathway induced by Nef. ..
  13. Jafari M, Guatelli J, Lewinski M. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014;88:5062-78 pubmed publisher
    ..is associated with the evolution of simian immunodeficiency virus (SIVcpz) into pandemic group M human immunodeficiency virus type 1 (HIV-1)...
  14. Gu J, Babayeva N, Suwa Y, Baranovskiy A, Price D, Tahirov T. Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle. 2014;13:1788-97 pubmed publisher
    Developing anti-viral therapies targeting HIV-1 transcription has been hampered by the limited structural knowledge of the proteins involved...
  15. Scharf L, Scheid J, Lee J, West A, Chen C, Gao H, et al. Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike. Cell Rep. 2014;7:785-95 pubmed publisher
    Broadly neutralizing antibodies (bNAbs) to HIV-1 envelope glycoprotein (Env) can prevent infection in animal models. Characterized bNAb targets, although key to vaccine and therapeutic strategies, are currently limited...
  16. Chen A, Sengupta P, Waki K, Van Engelenburg S, Ochiya T, Ablan S, et al. MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Proc Natl Acad Sci U S A. 2014;111:E2676-83 pubmed publisher
    ..define a previously unappreciated activity of miRNAs in inhibiting RNA-protein interactions that in the context of HIV-1 biology blocks HIV virus budding and reduces virus infectivity...
  17. Verstraete N, Kuzmina A, Diribarne G, Nguyen V, Kobbi L, Ludanyi M, et al. A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat. Retrovirology. 2014;11:50 pubmed publisher
    The positive transcription elongation factor b (P-TEFb) plays an essential role in activating HIV genome transcription...
  18. Bhattacharya A, Alam S, Fricke T, Zadrozny K, Sedzicki J, Taylor A, et al. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proc Natl Acad Sci U S A. 2014;111:18625-30 pubmed publisher
    Upon infection of susceptible cells by HIV-1, the conical capsid formed by ?250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription...
  19. Cimbro R, Gallant T, Dolan M, Guzzo C, Zhang P, Lin Y, et al. Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity. Proc Natl Acad Sci U S A. 2014;111:3152-7 pubmed publisher
    Elicitation of broadly neutralizing antibodies is essential for the development of a protective vaccine against HIV-1...
  20. Liu X, Shah A, Gangwani M, Silverstein P, Fu M, Kumar A. HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors. Sci Rep. 2014;4:4450 pubmed publisher
    The prevalence of HIV-associated neurocognitive disorders (HAND) remains high in patients infected with HIV-1...
  21. Ramirez P, Famiglietti M, Sowrirajan B, DePaula Silva A, RODESCH C, Barker E, et al. Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4? T cells. Cell Rep. 2014;7:2019-30 pubmed publisher
    ..Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells...
  22. Giese S, Marsh M. Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells. PLoS Pathog. 2014;10:e1004189 pubmed publisher
    Bst-2/Tetherin inhibits the release of HIV by tethering newly formed virus particles to the plasma membrane of infected cells...
  23. Pancera M, Zhou T, Druz A, Georgiev I, Soto C, Gorman J, et al. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014;514:455-61 pubmed publisher
    The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through ..
  24. Kuzmina A, Verstraete N, Galker S, Maatook M, Bensaude O, Taube R. A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription. Retrovirology. 2014;11:51 pubmed publisher
    Human immunodeficiency virus (HIV) gene expression is primarily regulated at the step of transcription elongation...
  25. Fricke T, White T, Schulte B, de Souza Aranha Vieira D, Dharan A, Campbell E, et al. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology. 2014;11:68 pubmed publisher
    The IFN-?-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Genetic evidence suggested that capsid is the viral determinant for restriction by MxB...
  26. Price A, Jacques D, McEwan W, Fletcher A, Essig S, Chin J, et al. Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathog. 2014;10:e1004459 pubmed publisher
    The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands...
  27. Lin D, Zimmermann S, Stuwe T, Stuwe E, Hoelz A. Structural and functional analysis of the C-terminal domain of Nup358/RanBP2. J Mol Biol. 2013;425:1318-29 pubmed publisher
    ..However, we demonstrate that the CTD is dispensable for nuclear envelope localization of Nup358, suggesting that the CTD does not interact with other nucleoporins. ..
  28. Ding S, Pan Q, Liu S, Liang C. HIV-1 mutates to evade IFITM1 restriction. Virology. 2014;454-455:11-24 pubmed publisher
    ..transmembrane (IFITM) proteins inhibit the infection of a wide range of viruses including human immunodeficiency virus type 1 (HIV-1). At present, little is known about how viruses overcome IFITM restriction...
  29. Munro J, Gorman J, Ma X, Zhou Z, Arthos J, Burton D, et al. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014;346:759-63 pubmed publisher
    The HIV-1 envelope (Env) mediates viral entry into host cells...
  30. Lindqvist M, van Lunzen J, Soghoian D, Kuhl B, Ranasinghe S, Kranias G, et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012;122:3271-80 pubmed publisher
    b>HIV targets CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell memory...
  31. Kitamura S, Ode H, Nakashima M, Imahashi M, Naganawa Y, Kurosawa T, et al. The APOBEC3C crystal structure and the interface for HIV-1 Vif binding. Nat Struct Mol Biol. 2012;19:1005-10 pubmed publisher
    ..However, HIV-1 viral infectivity factor (Vif) counteracts the antiviral activity of most A3 proteins by targeting them for ..
  32. Lochmann T, Bann D, Ryan E, Beyer A, Mao A, Cochrane A, et al. NC-mediated nucleolar localization of retroviral gag proteins. Virus Res. 2013;171:304-18 pubmed publisher
    ..targeted to nucleoli by a nucleolar localization signal (NoLS) in the NC domain, and similarly, the human immunodeficiency virus type 1 (HIV-1) NC protein also contains an NoLS consisting of basic residues...
  33. Harris R, Hultquist J, Evans D. The restriction factors of human immunodeficiency virus. J Biol Chem. 2012;287:40875-83 pubmed publisher
    Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers...
  34. Wilson S, Schoggins J, Zang T, Kutluay S, Jouvenet N, Alim M, et al. Inhibition of HIV-1 particle assembly by 2',3'-cyclic-nucleotide 3'-phosphodiesterase. Cell Host Microbe. 2012;12:585-97 pubmed publisher
    ..genes (ISGs) causes the cellular "antiviral state" in which the replication of many viruses, including HIV-1, is attenuated...
  35. Li Z, Guo J, Wu Y, Zhou Q. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res. 2013;41:277-87 pubmed publisher
    Latent HIV reservoirs are the primary hurdle to eradication of infection...
  36. Johnson B, Metifiot M, Ferris A, Pommier Y, Hughes S. A homology model of HIV-1 integrase and analysis of mutations designed to test the model. J Mol Biol. 2013;425:2133-46 pubmed publisher
    Although there are structures of the different domains of human immunodeficiency virus type 1 (HIV-1) integrase (IN), there is no structure of the entire protein...
  37. Jurado K, Wang H, Slaughter A, Feng L, Kessl J, Koh Y, et al. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A. 2013;110:8690-5 pubmed publisher
    Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target...
  38. Hori T, Takeuchi H, Saito H, Sakuma R, Inagaki Y, Yamaoka S. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly. J Virol. 2013;87:7726-36 pubmed publisher
    Since HIV-1 replication is modulated at multiple stages by host cell factors, identification and characterization of those host cell factors are expected to contribute to the development of novel anti-HIV therapeutics...
  39. Nazli A, Kafka J, Ferreira V, Anipindi V, Mueller K, Osborne B, et al. HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. J Immunol. 2013;191:4246-58 pubmed publisher
    Although women constitute half of all HIV-1-infected people worldwide (UNAIDS World AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during heterosexual HIV-1 transmission are poorly understood...
  40. Matreyek K, Yücel S, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog. 2013;9:e1003693 pubmed publisher
    ..showed that the viral capsid (CA) protein mediated the dependency on cellular nucleoporin (NUP) 153 during HIV-1 infection, and now demonstrate a direct interaction between the CA N-terminal domain and the phenylalanine-..
  41. Sharifi H, Furuya A, Jellinger R, Nekorchuk M, de Noronha C. Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex. J Virol. 2014;88:6944-58 pubmed publisher
    Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication...
  42. Kogan M, Deshmane S, Sawaya B, Gracely E, Khalili K, Rappaport J. Inhibition of NF-?B activity by HIV-1 Vpr is dependent on Vpr binding protein. J Cell Physiol. 2013;228:781-90 pubmed publisher
    ..We did not identify such a role for HSP27, which instead seems to inhibit Vpr functions. Chronically HIV-1 infected U1 cells with knockdown constructs for Vpr were unexpectedly less responsive to TNF-? mediated viral ..
  43. Shah A, Silverstein P, Kumar S, Singh D, Kumar A. Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. PLoS ONE. 2012;7:e52060 pubmed publisher
    b>HIV-1 envelope protein gp120 has been extensively studied for neurotoxic effects that have been attributed to the increased expression of various proinflammatory cytokines in the CNS...
  44. Mwimanzi P, Markle T, Martin E, Ogata Y, Kuang X, Tokunaga M, et al. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology. 2013;10:1 pubmed publisher
    Impaired HIV-1 Gag, Pol, and Env function has been described in elite controllers (EC) who spontaneously suppress plasma viremia to < 50 RNA copies/mL; however, activity of the accessory protein Nef remains incompletely characterized...
  45. De Iaco A, Santoni F, Vannier A, Guipponi M, Antonarakis S, Luban J. TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. Retrovirology. 2013;10:20 pubmed publisher
    Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity...
  46. Cooper A, García M, Petrovas C, Yamamoto T, Koup R, Nabel G. HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. Nature. 2013;498:376-9 pubmed publisher
    Human immunodeficiency virus-1 (HIV-1) has infected more than 60 million people and caused nearly 30 million deaths worldwide, ultimately the consequence of cytolytic infection of CD4(+) T cells...
  47. Khan K, Abbas W, Varin A, Kumar A, Di Martino V, Dichamp I, et al. HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages. J Innate Immun. 2013;5:639-56 pubmed publisher
    ..responses and control of apoptosis, which are key events in the pathogenesis of the human immunodeficiency virus (HIV)-1 and the hepatitis C virus (HCV) infections...
  48. Fricke T, Brandariz Nuñez A, Wang X, Smith A, Diaz Griffero F. Human cytosolic extracts stabilize the HIV-1 core. J Virol. 2013;87:10587-97 pubmed publisher
    The stability of the HIV-1 core in the cytoplasm is crucial for productive HIV-1 infection. Mutations that stabilize or destabilize the core showed defects on HIV-1 reverse transcription and infection...
  49. Bichel K, Price A, Schaller T, Towers G, Freund S, James L. HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358. Retrovirology. 2013;10:81 pubmed publisher
    Lentiviruses such as HIV-1 can be distinguished from other retroviruses by the cyclophilin A-binding loop in their capsid and their ability to infect non-dividing cells...
  50. Tugizov S, Herrera R, CHIN HONG P, Veluppillai P, Greenspan D, Michael Berry J, et al. HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013;446:378-88 pubmed publisher
    ..human papillomavirus (HPV)-associated epithelial lesions is substantially higher in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals...
  51. Kane M, Yadav S, Bitzegeio J, Kutluay S, Zang T, Wilson S, et al. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature. 2013;502:563-6 pubmed publisher
    b>HIV-1 replication can be inhibited by type I interferon (IFN), and the expression of a number of gene products with anti-HIV-1 activity is induced by type I IFN...
  52. Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, et al. Defining HIV-1 Vif residues that interact with CBF? by site-directed mutagenesis. Virology. 2014;449:82-7 pubmed publisher
    Vif is essential for HIV-1 replication in T cells and macrophages. Vif recruits a host ubiquitin ligase complex to promote proteasomal degradation of the APOBEC3 restriction factors by poly-ubiquitination...
  53. Arias J, Heyer L, von Bredow B, Weisgrau K, Moldt B, Burton D, et al. Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2014;111:6425-30 pubmed publisher
    ..b>HIV-1 overcomes this restriction factor by expressing HIV-1 viral protein U (Vpu), which down-regulates and degrades ..
  54. Aligeti M, Behrens R, Pocock G, Schindelin J, Dietz C, Eliceiri K, et al. Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. J Virol. 2014;88:14207-21 pubmed publisher
    Murine cells exhibit a profound block to HIV-1 virion production that was recently mapped to a species-specific structural attribute of the murine version of the chromosomal region maintenance 1 (mCRM1) nuclear export receptor and ..
  55. Kluge S, Mack K, Iyer S, Pujol F, Heigele A, Learn G, et al. Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin. Cell Host Microbe. 2014;16:639-50 pubmed publisher
    ..A deletion in human tetherin confers Nef resistance, representing a hurdle to successful zoonotic transmission. HIV-1 group M evolved to utilize the viral protein U (Vpu) to counteract tetherin...
  56. Götz N, Sauter D, Usmani S, Fritz J, Goffinet C, Heigele A, et al. Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host. Cell Host Microbe. 2012;12:373-80 pubmed publisher
    ..After cross-species transmission, the chimpanzee precursor of pandemic HIV-1 switched from the accessory protein Nef to Vpu to effectively counteract human tetherin...
  57. Fregoso O, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013;9:e1003496 pubmed publisher
    SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells...
  58. Izumi T, Burdick R, Shigemi M, Plisov S, HU W, Pathak V. Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity. J Virol. 2013;87:11047-62 pubmed publisher
    ..A3G) localize to cytoplasmic granules called processing bodies (P bodies), incorporate into human immunodeficiency virus type 1 (HIV-1) virions, and inhibit viral replication...
  59. Doria Rose N, Schramm C, Gorman J, Moore P, Bhiman J, DeKosky B, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 2014;509:55-62 pubmed publisher
    Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear...
  60. Serra Moreno R, Zimmermann K, Stern L, Evans D. Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog. 2013;9:e1003487 pubmed publisher
    ..Although the mechanisms of tetherin antagonism by HIV-1 Vpu and HIV-2 Env have been investigated in detail, comparatively little is known about tetherin antagonism by ..
  61. Yin X, Hu Z, Gu Q, Wu X, Zheng Y, Wei P, et al. Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol. 2014;88:1259-70 pubmed publisher
    ..Equine tetherin is localized on the cell surface and strongly blocks human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV) release ..
  62. Sabo Y, Walsh D, Barry D, Tinaztepe S, De los Santos K, Goff S, et al. HIV-1 induces the formation of stable microtubules to enhance early infection. Cell Host Microbe. 2013;14:535-46 pubmed publisher
    ..We show that HIV-1 induces the formation of acetylated and detyrosinated stable MTs early in infection...
  63. Morrison J, Guevara R, Marcano A, Saenz D, Fadel H, Rogstad D, et al. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014;88:3255-72 pubmed publisher
    ..Budding of bald FIV and HIV particles was blocked by carnivore tetherins...
  64. Guan Y, Pazgier M, Sajadi M, Kamin Lewis R, Al Darmarki S, Flinko R, et al. Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc Natl Acad Sci U S A. 2013;110:E69-78 pubmed publisher
    The HIV-1 envelope glycoprotein (Env) undergoes conformational transitions consequent to CD4 binding and coreceptor engagement during viral entry...
  65. Izquierdo Useros N, Lorizate M, Puertas M, Rodriguez Plata M, Zangger N, Erikson E, et al. Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol. 2012;10:e1001448 pubmed publisher
    ..However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells...
  66. Nookala A, Shah A, Noel R, Kumar A. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-?B, AP-1, C/EBP? and C/EBP? transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways. PLoS ONE. 2013;8:e78855 pubmed publisher
    The incidence of HIV-associated neurological disorders (HAND) has increased during recent years even though the highly active antiretroviral therapy (HAART) has significantly curtailed the virus replication and increased the life ..
  67. Steckbeck J, Kuhlmann A, Montelaro R. C-terminal tail of human immunodeficiency virus gp41: functionally rich and structurally enigmatic. J Gen Virol. 2013;94:1-19 pubmed publisher
    The human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) pandemic is amongst the most important current worldwide public health threats...
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    Use of Env in HIV vaccine development has been disappointing...
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    ..Virus assembly in HIV is a remarkably well coordinated process in which the virus achieves extracellular budding using primarily ..
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    The native HIV-1 Env complex consists of a gp120/gp41 trimer, but surface plasmon resonance (SPR)-directed binding studies for gp120-binding agents were almost exclusively performed on monomeric gp120...
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    b>HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology...
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    The HIV transactivator protein, Tat, enhances HIV transcription by recruiting P-TEFb from the inactive 7SK snRNP complex and directing it to proviral elongation complexes...
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    The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition...
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    b>HIV-1 negative factor (Nef) elevates virus replication and contributes to immune evasion in vivo. As one of its established in vitro activities, Nef interferes with T-lymphocyte chemotaxis by reducing host cell actin dynamics...
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    New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition...
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    ..Restriction of HIV-1 by rhesus TRIM5? (TRIM5?rh) has been correlated to its ability to bind to the HIV-1 core, suggesting that capsid ..
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    ..We demonstrate that Tat recruits PPM1G/PP2C? to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop...
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    Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a global health priority...
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    Nuclear export of unspliced and singly spliced viral mRNA is a critical step in the HIV life cycle...
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    Cardiac involvement is a well-documented complication of human immunodeficiency virus-1 (HIV-1) infection. Previous studies have demonstrated increased adhesion of monocytes to human vascular endothelial cells in HIV-infected individuals...
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    ..Three recent papers, including one in this issue of Cell Host & Microbe, show that MxB inhibits human immunodeficiency virus type 1 (HIV-1) infection.
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    Vpu is a multifunctional accessory protein that enhances the release of HIV-1 by counteracting the entrapment of nascent virions on infected cell surface mediated by BST2/Tetherin...
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    Vascular diseases supported by aberrant angiogenesis have increased incidence in HIV-1-infected patients...
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    The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors...
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    b>HIV-1 reverse transcription is achieved in the newly infected cell before viral DNA (vDNA) nuclear import...
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    ..is an interferon-inducible transmembrane protein that restricts the release of several enveloped viruses, including HIV, from infected cells...
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    Over the past several decades, extensive research into the Gag polyprotein, the main structural protein of HIV-1 and all other retroviruses, has changed the way that we describe Gag's role within viral lifecycles...
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    ..The HIV-1 Tat protein selectively recruits P-TEFb as part of a super elongation complex (SEC) organized on a flexible AFF1 ..
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    b>HIV-1 entry into CD4(+) target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4...
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    Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine...
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    The structural flexibility found in human immunodeficiency virus (HIV) envelope glycoproteins creates a complex relationship between antigenicity and sensitivity to antiviral antibodies...
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    Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans...
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    ..We find that BET inhibitor compounds (JQ1, I-Bet, I-Bet151 and MS417) reactivate HIV from latency...
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    Cellular restriction factors help to defend humans against human immunodeficiency virus (HIV)...
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    ..For HIV-1, specific recruitment of tetherin to assembly sites has been observed as its colocalization with the viral ..
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    ..This approach is based on our identification of an egress-defective Vpu variant encoded by an HIV-1 subtype C strain...
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    Retroviruses, including HIV, can activate innate immune responses, but the host sensors for retroviruses are largely unknown...