Human T-lymphotropic virus 1

Summary

Alias: Human lymphotropic virus type I, human T-lymphotropic virus type I HTLV-I, human T-lymphotropic virus type 1 HTLV-1, human T-cell lymphotropic virus type 1, HTLV-1, human T-cell lymphoma/leukemia virus type I HTLV-I, human T-cell leukemia/lymphotropic virus type I HTLV-I, human T-cell leukemia/lymphoma virus type I HTLV-I, human T-cell leukemia virus type 1 HTLV-1, human T-cell leukemia virus I, human T cell lymphotropic virus type I HTLV-I, human T cell leukemia virus type 1 HTLV-1, Human adult T-cell leukemia virus, Human T-cell lymphotropic virus type I, Human T-cell lymphotropic virus type 1, Human T-cell lymphotropic virus 1, Human T-cell leukemia virus type I HTLV-I, Human T-cell leukemia virus type I, Human T-cell leukemia virus type 1, Human T cell leukemia virus type 1, HTLV-1, HTLV-I, human T cell leukemia virus type I HTLV-I, human T-cell leukemia virus-1 HTLV-1, Human T-cell lymphotrophic virus type 1, Human T-lymphotropic virus type 1

Top Publications

  1. pmc Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300
    Julita A Ramírez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Mol Biol 372:958-69. 2007
  2. pmc Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006
  3. ncbi Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function
    Cynthia A Pise-Masison
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41 Room B201, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Front Biosci 10:919-30. 2005
  4. ncbi Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax
    Guo Jin Huang
    National Key Laboratory for Molecular Virology, Institute of Virology, 100 Yingxin Street, 100052, Beijing, PR China
    FEBS Lett 531:494-8. 2002
  5. pmc The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, The Leroy T Canoles Jr Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA 23508, USA
    Blood 119:1173-81. 2012
  6. pmc Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, Norfolk, VA 23507, USA
    J Virol 83:5339-52. 2009
  7. pmc Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    Julie Lodewick
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, Universite Libre de Bruxelles, 1, avenue Emile Gryson, B 1070 Brussels, Belgium
    Virology 386:68-78. 2009
  8. doi Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication
    Kazumi Nakano
    Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Minatoku, Tokyo, Japan
    Microbes Infect 15:491-505. 2013
  9. ncbi Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
    Katja Wäldele
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, D 91054 Erlangen, Germany
    Blood 107:4491-9. 2006
  10. doi Functional interaction of HTLV-1 tax protein with the POZ domain of the transcriptional repressor BCL6
    J Dean
    UCD Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Oncogene 28:3723-34. 2009

Research Grants

  1. HIV & HTLV-I COHORT STUDIES OF HAITIAN WOMEN AND INFANTS
    Neal Halsey; Fiscal Year: 1991
  2. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2006
  3. Pooja Jain; Fiscal Year: 2016
  4. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
  5. Chou Zen Giam; Fiscal Year: 2014
  6. Michael Levin; Fiscal Year: 2016
  7. Chou Zen Giam; Fiscal Year: 2014
  8. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2012
  9. Louis M Mansky; Fiscal Year: 2015
  10. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010

Patents

  1. Model animal for Adult T-cell lymphoma
  2. Method for detecting Human T-cell lymphotropic virus HBZ protein
  3. METHODS FOR BLADDER CANCER THERAPY USING BACULOVIRAL VECTORS
  4. Method for improvement of detection sensitivity of anti-HTLV antibody in immunoassay
  5. METHODS FOR BLADDER CANCER THERAPY USING BACULOVIRAL VECTORS
  6. Nonylphenol(NP) responsive genes in Oryzias javanicus and the method for diagnosing aquatic environment pollution using the same
  7. No title supplied
  8. AEQUORIN FUSED TO PROTEIN HAVING SPECIFIC BONDING CAPABILITY AND PRODUCTION THEREOF
  9. Control plasmid and method for detecting mycoplasma contamination in biological material
  10. MANIFESTATION PLASMID AND USE THEREOF

Detail Information

Publications224 found, 100 shown here

  1. pmc Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300
    Julita A Ramírez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Mol Biol 372:958-69. 2007
    ..We also show that MLL competes with Tax for KIX binding, suggesting a novel mechanism of Tax oncogenesis in which normal MLL function is disrupted by Tax...
  2. pmc Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006
    ..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
  3. ncbi Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function
    Cynthia A Pise-Masison
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41 Room B201, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Front Biosci 10:919-30. 2005
    ..This review will concentrate on the ability of Tax to promote cellular proliferation through activation of the NF-kappaB pathway while inhibiting the cell-cycle checkpoint and apoptotic function of the tumor suppressor gene p53...
  4. ncbi Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax
    Guo Jin Huang
    National Key Laboratory for Molecular Virology, Institute of Virology, 100 Yingxin Street, 100052, Beijing, PR China
    FEBS Lett 531:494-8. 2002
    ..Taken together, our findings suggest a new model of Tax activation of NF-kappaB, in which Tax interacts with IKK-gamma to stimulate its oligomerization...
  5. pmc The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, The Leroy T Canoles Jr Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA 23508, USA
    Blood 119:1173-81. 2012
    ..These results provide important new insight into STUbL-mediated pathways that regulate the subcellular localization and functional dynamics of viral oncogenes...
  6. pmc Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization
    Kimberly A Fryrear
    Department of Microbiology and Molecular Cell Biology, Norfolk, VA 23507, USA
    J Virol 83:5339-52. 2009
    ..Thus, we defined additional domains in Tax specific for nuclear localization and subnuclear targeting. Our results reveal a more complex network for regulation of Tax subcellular localization and subsequent function...
  7. pmc Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    Julie Lodewick
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, Universite Libre de Bruxelles, 1, avenue Emile Gryson, B 1070 Brussels, Belgium
    Virology 386:68-78. 2009
    ..Thus, Tax acetylation favors NF-kappaB activation and might play an important role in HTLV-1-induced cell transformation...
  8. doi Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication
    Kazumi Nakano
    Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Minatoku, Tokyo, Japan
    Microbes Infect 15:491-505. 2013
    ..Thus, we suggest that Rex not only stabilizes viral transcripts, but also perturbs cellular mRNA metabolism and host cell homeostasis via inhibition of NMD...
  9. ncbi Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
    Katja Wäldele
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, D 91054 Erlangen, Germany
    Blood 107:4491-9. 2006
    b>Human T cell leukemia virus type 1 (HTLV-1), the cause of adult T cell leukemia (ATL), induces clonal expansion of infected T-cells in nonleukemic individuals and immortalizes T cells in vitro...
  10. doi Functional interaction of HTLV-1 tax protein with the POZ domain of the transcriptional repressor BCL6
    J Dean
    UCD Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
    Oncogene 28:3723-34. 2009
    ..This suggests that the expression of BCL6 in HTLV infected cells may contribute to the silencing of viral gene expression and to the long clinical latency associated with HTLV infection...
  11. pmc Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery
    Rachel Van Duyne
    Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 7:e40662. 2012
    ..Finally, the changes in cellular miRNA expression in HTLV-1 infected cells can be mimicked by the add back of Drosha or the addition of antagomiRs against the cellular miRNAs which are downregulated by the virus...
  12. ncbi Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
    D Y Jin
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    Cell 93:81-91. 1998
    ..We propose a model of viral transformation in which Tax targets TXBP181, thereby abrogating a mitotic checkpoint...
  13. doi Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Virology 407:341-51. 2010
    ..These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo...
  14. pmc Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein
    Kerstin Haller
    Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
    Mol Cell Biol 22:3327-38. 2002
    ..Thus, protein-protein contact between Tax and the components of the cyclin D/CDK complexes provides a further mechanistic explanation for the mitogenic and immortalizing effects of this HTLV-1 oncoprotein...
  15. ncbi Protein profile of tax-associated complexes
    Kaili Wu
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
    J Biol Chem 279:495-508. 2004
    ....
  16. pmc Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein
    Isabelle Lamsoul
    Institute for Microbiological Research J M Wiame, 1 Avenue E Gryson, B 1070 Brussels, Belgium
    Mol Cell Biol 25:10391-406. 2005
    ..These modifications may result in targets for the treatment of adult T-cell leukemia...
  17. ncbi Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells
    Yana Schavinsky-Khrapunsky
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int J Cancer 122:305-16. 2008
    ..The mechanisms of the NF-kappaB-associated effects on the level and function of the cellular w.t.p53 and of the p53-independent NER noted in our experimental systems are further investigated in our laboratory...
  18. pmc MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes
    Klemens Pichler
    Institute of Clinical and Molecular Virology, University Erlangen Nuremberg, Schlossgarten 4, Erlangen, Germany
    Retrovirology 5:100. 2008
    ..Affecting e.g. proliferation, microRNAs constitute a potential target for viral interference on the way to persistence and transformation. Hence, we explored the interconnections between HTLV-1 and cellular microRNAs...
  19. pmc NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ
    Huijun Zhi
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    PLoS Pathog 7:e1002025. 2011
    Activation of I-κB kinases (IKKs) and NF-κB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation...
  20. ncbi Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway
    Edward W Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
    Virology 333:145-58. 2005
    The human T cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is etiologically linked to the genesis of adult T cell leukemia (ATL) as well as HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
  21. ncbi Phosphorylation of the HTLV-1 matrix L-domain-containing protein by virus-associated ERK-2 kinase
    Bénédicte Hémonnot
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, Centre National pour la Recherche Scientifique UMR5121 Université Montpellier 1, Institut de Biologie, 4 Boulevard Henri IV, CS89508, 34960 Montpellier Cedex 2, France
    Virology 349:430-9. 2006
    ..Our data thus support the postulate that phosphorylation of retroviral L-domain proteins is a common feature to retroviruses that participates in the regulation of viral budding...
  22. pmc Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling
    Jean Claude Twizere
    Department of Cellular and Molecular Biology, Faculty of Gembloux, Belgium
    Blood 109:1051-60. 2007
    ..Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies...
  23. ncbi Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation
    Young Mi Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    J Biol Chem 282:18750-7. 2007
    ..Because pCREB has been implicated in leukemogenesis, enhancement of CREB phosphorylation by the virus may play a role in the etiology of adult T-cell leukemia...
  24. ncbi Human T-cell leukemia virus type 1 Tax and cellular transformation
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Int J Hematol 86:101-6. 2007
    ..In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis...
  25. ncbi The HTLV-I Tax oncoprotein: hyper-tasking at the molecular level
    Diane R Wycuff
    Dept Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Front Biosci 10:620-42. 2005
    ..Whereas for the virus these functions of Tax provide a means for successful completion of its life cycle, for the cell, they result at best in anarchy, and at worst in death of both the cell and the organism of which that cell is a part...
  26. ncbi HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease
    Timothy Alefantis
    Vital Probes, Inc, 1300 Old Plank Road, Mayfield, PA 18433, USA
    J Biomed Sci 12:961-74. 2005
    The human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax interacts with numerous cellular pathways promoting both the survival and pathogenesis of the virus in the human population...
  27. ncbi Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB
    Kazuo Okamoto
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 11:177-91. 2006
    ..Taken together, Tax inhibits Fas-mediated apoptosis by up-regulating c-FLIP expression in HTLV-I-infected cells, and NF-kappaB activity plays an essential role in the up-regulation of c-FLIP...
  28. pmc Human T Lymphotropic Virus Type 1 protein Tax reduces histone levels
    James M Bogenberger
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
    Retrovirology 5:9. 2008
    ..All of these Tax effects are thought to cooperate in the development of ATLL...
  29. ncbi Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 281:31705-12. 2006
    ..These results suggest that both positive and negative phosphorylation signals result in the maintenance of a subfraction of Tax as "active" protein...
  30. pmc HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex
    Randall Merling
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Retrovirology 4:35. 2007
    ..Importantly, the ability of these mutants to activate APC/C is attenuated or abrogated. These data indicate that Tax-induced rapid senescence is causally associated with APC/C activation...
  31. pmc Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
    S S Lee
    Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:6670-5. 1997
    ..b>Human T cell leukemia virus type 1 Tax and most oncogenic human papillomavirus E6 oncoproteins also possessed PDZ domain-binding motifs ..
  32. ncbi Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding
    Vincent Blot
    Departement de Biologie Cellulaire, CNRS UMR 8104 and INSERM U567, Institut Cochin, 75014 Paris, France
    J Cell Sci 117:2357-67. 2004
    ..Our findings indicate that Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur...
  33. pmc The human T-cell leukemia virus Rex protein
    Ihab Younis
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Front Biosci 10:431-45. 2005
    ..Herein we summarize the progress made towards understanding Rex function and its role in the HTLV life cycle...
  34. ncbi The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation
    Kylene Kehn
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, DC 20037, USA
    Oncogene 24:525-40. 2005
    ..Therefore, we propose a model whereby Tax targets Rb to the proteasome by acting as a molecular bridge bringing Rb into contact with the proteasome for degradation...
  35. pmc HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule
    Baoying Liu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:63-8. 2005
    ..Unscheduled activation of APC(Cdc20) by Tax provides an explanation for the mitotic abnormalities in HTLV-I-infected cells and is likely to play an important role in the development of adult T cell leukemia...
  36. ncbi Secretion of the human T cell leukemia virus type I transactivator protein tax
    Timothy Alefantis
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:17353-62. 2005
    b>Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis...
  37. ncbi Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR
    Takeshi Ego
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, 53 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 24:1914-23. 2005
    ..Our observation provides insight into the epigenetic regulation of gene expression and the diverse mechanisms of transcriptional regulation using methylated promoters...
  38. pmc Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
    Franca Majone
    Department of Biology, University of Padua, Padua, Italy
    Retrovirology 2:45. 2005
    ..Taken together, our findings suggest Ku80 as a cellular factor targeted by Tax in engendering clastogenic DNA damage...
  39. ncbi Human T cell leukemia virus type 1: the role of Tax in leukemogenesis
    Cynthia A Pise-Masison
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Arch Immunol Ther Exp (Warsz) 53:283-96. 2005
    b>Human T cell leukemia virus type 1 (HTLV-1) is a complex human retrovirus which is the causative agent of adult T cell leukemia (ATL). ATL occurs in about 4% of carriers and develops after a long latent period...
  40. ncbi Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax
    Hakju Kwon
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Biol Chem 280:35713-22. 2005
    ..Of note, this skin disease completely resolved when Tax transgene expression was suppressed by administration of doxycycline, emphasizing the key role played by this viral oncoprotein in the observed pathology...
  41. pmc HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
    Ling Gao
    Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 S Euclid Ave, Box 8069, St Louis, MO 63110, USA
    Blood 106:4294-302. 2005
    ....
  42. ncbi HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane
    Dmitriy Mazurov
    National Cancer Institute, HIV Drug Resistance Program, Bld 535, Rm 110, NCI Frederick, Frederick, MD 21702 1201, USA
    Virology 346:194-204. 2006
    ..Our data suggest that once at the plasma membrane, HTLV-1 virion components associate with CD82-containing microdomains, which may facilitate the mobilization of nascent virions to sites of intercellular adhesion...
  43. pmc SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
    Koju Kamoi
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    Retrovirology 3:5. 2006
    ....
  44. ncbi Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1
    Isabelle Lemasson
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    J Biol Chem 281:13075-82. 2006
    ..These results support a model in which nucleosomes are depleted from the LTR and transcribed region during Tax-mediated transcriptional activation and correlate RNA polymerase II recruitment with nucleosome depletion...
  45. pmc Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax
    Soo Jin Jeong
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Building 41, Room B302, Bethesda, MD 20892, USA
    J Virol 80:10036-44. 2006
    ..Together, our data provide evidence that CARM1 enhances Tax transactivation of the HTLV-1 LTR through a direct interaction between CARM1 and Tax and this binding promotes methylation of histone H3 (R2, R17, and R26)...
  46. ncbi Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains
    Hicham Baydoun
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, University of Brussels, Belgium
    Gene 386:191-201. 2007
    ..These data support the idea that the transcriptional and post-transcriptional regulation of HTLV-1 gene expression depends on the concentration of select regulatory complexes at specific area of the nucleus...
  47. ncbi Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    Nicole S Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 282:4185-92. 2007
    b>Human T cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia. HTLV-1 encodes a trans-activating protein, Tax, which is largely responsible for the oncogenic properties of the virus...
  48. ncbi Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax
    Sohee Hong
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 282:12119-26. 2007
    ..Tax-PP2A interaction, however, renders PP2A inactive, thus maintaining Tax-PP2A-IKK in an active state. Finally, CCR2 and LZ possibly inhibit IKK activation by stabilizing the HLX2-CCR2-LZ bundle...
  49. pmc Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
    Xuefeng Wu
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PO Box 850, Hershey, Pennsylvania 17033, USA
    EMBO Rep 8:510-5. 2007
    ..These findings show a pathological mechanism of IKK activation by Tax and provide an example for how IKK is persistently activated in cancer cells...
  50. pmc Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection
    Heather Y Winter
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 81:6089-98. 2007
    ..These results suggest that Tax activates SRF-responsive transcription by enhancing its binding affinity to multiple different SRE sequences...
  51. ncbi Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2
    Saurabh K Gupta
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 282:29431-40. 2007
    ..We propose that Tax binding via the Chk2 kinase domain sequesters phosphorylated Chk2 within chromatin, thus hindering chromatin egress and appropriate response to DNA damage...
  52. ncbi The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells
    Charlotte Arpin-André
    Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante, Centre National de la Recherche Scientifique UM 1 UM 2 UMR 5236 IFR 122, Institut de Biologie, 4 Boulevard Henri IV, Montpellier Cedex 2, France
    J Biol Chem 282:33132-41. 2007
    ..In this regard, the oncogenic potential of the human T cell leukemia virus type 1 Tax protein correlates with its binding capacity to the tumor suppressor hDlg...
  53. ncbi Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome
    Y Kfoury
    Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
    Oncogene 27:1665-76. 2008
    ..These observations highlight an unsuspected link between Tax-induced IKK activation and the centrosome...
  54. pmc The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA
    J Virol 81:13735-42. 2007
    ..Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation...
  55. pmc The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB
    Timothy R Geiger
    Department of Biochemistry and Molecular Biology, Campus Box 1870, Colorado State University, Fort Collins, CO 80523 1870, USA
    Mol Cell Biol 28:1383-92. 2008
    ..The regulation of transcription by pCREB is therefore more complex than is generally recognized, and coregulators, such as Tax, likely play a critical role in the modulation of pCREB function...
  56. ncbi Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 180:931-9. 2008
    ..CD4+ T cell malignancy which predominantly expresses CCR4 and is etiologically associated with human T cell leukemia virus type 1 (HTLV-1)...
  57. doi Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein
    Klemens Pichler
    Institute of Clinical and Molecular Virology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Blood 111:4741-51. 2008
    ..Thus, 4-1BB up-regulation by Tax could contribute to growth, survival, and clonal expansion of the infected cells during persistence and disease...
  58. pmc Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway
    Di Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:16299-308. 2008
    ..CREB-1 directly at the cAMP-responsive element both in vitro and in vivo. These findings suggest a role for ZNF268 in aberrant T-cell proliferation observed in HTLV-1-associated diseases...
  59. pmc Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response
    Chandtip Chandhasin
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:6952-61. 2008
    ..Attempts to replicate in the presence of these lesions would result in gradual accumulation of mutations, leading to genome instability and cellular transformation...
  60. pmc HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 283:36311-20. 2008
    ..We also describe a novel interaction between DNA-PK and Chk2 that requires Tax. We propose that Tax binds to and stabilizes a protein complex with DNA-PK and Chk2, resulting in a saturation of DNA-PK-mediated damage repair response...
  61. doi HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis
    Nicola Vajente
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Via Gattamelata 64, 35128 Padova, Italy
    Apoptosis 14:153-63. 2009
    ..As a whole, our findings provide intriguing evidence of a possible link between Ras signaling and Tax capability to counteract apoptosis and to enhance P-CREB levels, and implicates a potential role for Ras in HTLV-1-induced diseases...
  62. doi The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation
    Soo Jin Jeong
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 381:294-9. 2009
    ..Our current study demonstrates an important role for Pin1 in the post-translational regulation of Tax and suggests that the targeting of Pin1 may offer a new insight into the pathogenesis of HTLV-1 related diseases...
  63. pmc Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
    Ling Zhang
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    Retrovirology 6:35. 2009
    ..The possible involvement of Tax-mediated APC/C activation in p21(CIP1/WAF1) mRNA stabilization is discussed...
  64. doi The avidity and lytic efficiency of the CTL response to HTLV-1
    Tarek Kattan
    Department of Immunology, Wright Fleming Institute, Imperial College London, United Kingdom
    J Immunol 182:5723-9. 2009
    ..CTL quality determines the position of virus-host equilibrium in persistent HTLV-1 infection...
  65. doi HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse
    Mohamed Nejmeddine
    Department of Immunology, Wright Fleming Institute, Imperial College, Norfolk Pl, London W2 1PG London, United Kingdom
    Blood 114:1016-25. 2009
    ..The results also reveal differences in the signaling pathways used to trigger MTOC polarization between the immunologic synapse and the virological synapse...
  66. pmc Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease
    Sharron L Manuel
    Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Leukoc Biol 86:1205-16. 2009
    ..Our studies clearly establish a role for this important immune cell component in HTLV-1 immuno/neuropathogenesis and suggest that modulation of DC functions could be an important tool for therapeutic interventions...
  67. pmc Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
    Toshiyuki Shoji
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:83. 2009
    ..This distinction was mediated by at least two Tax1 specific functions, an interaction with host cellular factors through the PDZ domain binding motif (PBM) and the activation of NF-kappa B2 (NF-kappa B2)/p100...
  68. doi MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells
    Mariko Tomita
    University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 130:2300-9. 2012
    ..Moreover, overexpression of miR-146a enhanced the growth of an HTLV-1-infected T-cell line. Our findings suggest that miR-146a is a potentially suitable therapeutic target of ATL...
  69. pmc Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:117. 2009
    ..In this review, we summarize the functions of Tax1 associated with cell survival, cell proliferation, persistent infection as well as pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2...
  70. pmc HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes
    Marcia Bellon
    University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Center for Viral Oncology, KU Cancer Center, Kansas City, KS 66160, USA
    Blood 115:2441-8. 2010
    ..These data provide a better understanding of Tax functions in human T cells, and highlight the limitations of Tax, suggesting that other viral proteins are key to T-cell transformation and development of adult T-cell leukemia...
  71. pmc Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker
    Takao Kinjo
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 84:5431-7. 2010
    ..Our data suggest that ROS induction explains Tax-induced cellular DNA damage and cellular senescence...
  72. doi Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells
    Kousuke Saito
    Department of Microbiology, Kanazawa Medical University School of Medicine, Ishikawa 920 0293, Japan
    Virology 403:173-80. 2010
    ..Our results indicate that the overexpression of Bcl3 in HTLV-1-infected T cells is regulated not only by transcriptional but also by post-transcriptional mechanisms, and is involved in overgrowth of HTLV-1-infected T cells...
  73. doi The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif
    Carlo Bidoia
    Department of Life and Reproduction Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, Verona, Italy
    Virus Genes 41:149-57. 2010
    ..These results suggest that CK2, whose constitutive activity is often hijacked by viruses to sustain their vital cycle, could modulate Tax-1 oncogenic interactions...
  74. pmc Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis
    J Fu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oncogene 29:6499-507. 2010
    ..These studies dissect functional sequences within PDLIM2 and their distinct roles in Tax regulation...
  75. doi Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing
    Makoto Abe
    Department of Life and Environmental Sciences, Chiba Institute of Technology, Narashino, Chiba, Japan
    FEBS Lett 584:4313-8. 2010
    ..These results suggest that the interaction of Dicer with HTLV-I Rex inhibits Dicer activity and thereby reduces the efficiency of the conversion of shRNA to siRNA...
  76. doi Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation
    Francesca Avesani
    Department of Life and Reproduction Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, Verona, Italy
    Virology 408:39-48. 2010
    ..Co-expression of RelA and/or TAB2 markedly increased Tax-mediated NF-κB activation. These findings provide new insights into the role of RelA, TAB2 and Tax in the deregulation of the NF-κB pathway...
  77. pmc The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30(II) mRNA
    Gunjan Choudhary
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO, USA
    Virology 410:307-15. 2011
    ..Mutation of p30(II) overcame the effects of the splice acceptor mutation of hbz, and restored tax expression. Thus, there is a complex interplay of viral regulatory proteins controlling levels of HTLV-1 gene expression...
  78. doi The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-kappaB signals
    Andrea K Kress
    Institute of Clinical and Molecular Virology, Friedrich Alexander Universitat Erlangen Nurnberg, Schlossgarten 4, Erlangen, Germany
    Blood 117:3609-12. 2011
    ..Nuclear factor-κB signals were important for Tax-mediated transcriptional regulation of Fascin in T cells. This suggests that Fascin up-regulation by Tax contributes to the development of HTLV-1-associated pathogenesis...
  79. pmc Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling
    Junichiro Yasunaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 85:6212-9. 2011
    ..Infection by human T cell leukemia virus type 1 (HTLV-1) causes a fatal hematopoietic malignancy termed adult T cell leukemia (ATL)...
  80. pmc The HTLV-1 Tax oncoprotein represses Ku80 gene expression
    Razvan I Ducu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 416:1-8. 2011
    ..The reduction of Ku80 transcription by Tax may deplete the cell of an essential DNA break binding protein, resulting in reduced repair of DNA double strand breaks and accumulation genomic mutations...
  81. pmc Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles
    Vibeke Andresen
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    Blood 118:1549-59. 2011
    ..Further, these results highlight the importance of studying the function of the HTLV-1 viral proteins, not only in isolation, but also in the context of full viral replication...
  82. pmc Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences
    Umberto Bertazzoni
    Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Viruses 3:541-60. 2011
    ..Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity...
  83. pmc Move or die: the fate of the Tax oncoprotein of HTLV-1
    Julie Lodewick
    Institut de Recherches Microbiologiques J M Wiame, Universite Libre de Bruxelles, B 1070 Bruxelles, Belgium
    Viruses 3:829-57. 2011
    ....
  84. doi Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth
    Manami Yoshita
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer Sci 103:369-74. 2012
    ..These results suggest that Tax activates the mTOR pathway in T cells, and that this activation plays a crucial role in the growth of HTLV-1-infected T cells when a limited amount of IL-2 is available...
  85. pmc Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators
    Chirine Toufaily
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, SB R860, 2080 St Urbain, Montreal, Quebec, H2X 3X8, Canada
    Viruses 3:2146-59. 2011
    ..Our results thus demonstrated that HTLV-1 Tax activates several HERV LTRs. This raises the possibility that upregulated HERV expression could be involved in diseases associated with HTLV-1 infection...
  86. pmc HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA
    Yik Khuan Ho
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Virol 86:9474-83. 2012
    ..The senescence checkpoint triggered by Tax is driven by the transcriptional activity of NF-κB, which depends on activated IKKα and p65/RelA...
  87. doi Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 Tax
    Shuichi Kusano
    Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Virology 432:343-52. 2012
    ..PLSCR1 may play an important role in the IFN-mediated repression of Tax-dependent transactivation during HTLV-1 infection...
  88. pmc HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ
    Hicham H Baydoun
    University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, Kansas, USA
    PLoS ONE 7:e42226. 2012
    ..Although HTLV-I-transformed leukemic cells have numerous genetic lesions, the precise role of the viral tax gene in this process is not fully understood...
  89. pmc NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
    Gutian Xiao
    University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA
    Retrovirology 9:78. 2012
    ..Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing...
  90. doi Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells
    Michitaka Imai
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Virus Genes 46:39-46. 2013
    While human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia, a close relative, HTLV-2, is not associated with any leukemia...
  91. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  92. pmc HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication
    Linlin Gao
    Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, The University of Miami Miller School of Medicine, Miami, Florida, USA
    J Virol 87:13640-54. 2013
    ..Taken together, our results reveal that Tax is a novel HSP90 client protein and HSP90 inhibitors may exert therapeutic benefits for ATL and HAM/TSP patients. ..
  93. doi Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction
    Masaaki Okajima
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 37:231-40. 2008
    ..These results suggest that Tax1 through two binding sites induce aberrant clustering of Scribble, thereby altering the functions in HTLV-1-infected cells, which may thus play a role in persistent HTLV-1 infection and the pathogenesis...
  94. pmc Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis
    Michelle Sieburg
    SUNY Upstate Medical University, Department of Microbiology and Immunology, 750 East Adams St, Syracuse, NY 13210, USA
    J Virol 78:10399-409. 2004
    ..Characterization of the unique phenotypes displayed by Tax1 and Tax2 in vitro will provide information as to the relative roles of these oncoproteins and their contribution to HTLV-1 and -2 pathogenesis in vivo...
  95. ncbi Mycosis fungoides in European Russia: no antibodies to human T cell leukemia virus type I structural proteins, but virus-like sequences in blood and saliva
    Vladimir A Morozov
    Retrovirology, Robert Koch Institut, Berlin, Germany
    Intervirology 48:362-71. 2005
    Mycosis fungoides (MF) is the most frequent form of cutaneous T cell lymphoma (CTCL). Human T cell leukemia virus type 1 (HTLV-1) involvement in MF progression is a matter of debate...
  96. pmc IFN-gamma production in response to Tax 161-233, and frequency of CD4+ Foxp3+ and Lin HLA-DRhigh CD123+ cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population
    Ivan Best
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Immunology 128:e777-86. 2009
    ....
  97. ncbi Anti-HTLV-1 tax antibody and tax-specific cytotoxic T lymphocyte are associated with a reduction in HTLV-1 proviral load in asymptomatic carriers
    Masaki Akimoto
    Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan
    J Med Virol 79:977-86. 2007
    ..Tax-specific CTL may reduce HTLV-1 proviral load to prevent asymptomatic carriers from developing adult T-cell leukemia/lymphoma...
  98. ncbi HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru
    K Verdonck
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Tuberc Lung Dis 11:1066-72. 2007
    ..Tuberculosis (TB) and human T-lymphotropic virus 1 (HTLV-1) are frequent in Peru. The prevalence of HTLV-1 among Peruvian TB patients is unknown...
  99. pmc In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection
    Becca Asquith
    Department of Immunology, Imperial College, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 104:8035-40. 2007
    ..We suggest that there is persistent viral gene expression in vivo, which is necessary for the maintenance of the proviral load and determines HTLV-1-associated myelopathy/tropical spastic paraparesis risk...
  100. ncbi The World Health Organization classification of malignant lymphoma: incidence and clinical prognosis in HTLV-1-endemic area of Fukuoka
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Pathol Int 52:1-12. 2002
    ..We conclude that the histological, phenotypic and genotypic classification of the new WHO system should be beneficial for the clinical approach to these tumors...

Research Grants66

  1. HIV & HTLV-I COHORT STUDIES OF HAITIAN WOMEN AND INFANTS
    Neal Halsey; Fiscal Year: 1991
    ..I infections in a high risk developing country population. The quantitative data will assist health care providers to develop strategies for the control of HIV and HTLV-I in this and similar populations throughout the world...
  2. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2006
    ..Through these combined in vivo and in vitro experiments, we hope to gain key insights into the molecular events underlying HTLV-I Tax mediated leukemogenesis. ..
  3. Pooja Jain; Fiscal Year: 2016
    ....
  4. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..Consequently, human T cell leukemia virus type 1 (HTLV-1) has been used as a model pathogen to explore the role of DCs in virus- induced ..
  5. Chou Zen Giam; Fiscal Year: 2014
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer ..
  6. Michael Levin; Fiscal Year: 2016
    ..The combination of both a diagnostic and pathogenic immune reaction is of particular relevance and has the potential to make important contributions to the long- term care and outcomes of people with MS. ..
  7. Chou Zen Giam; Fiscal Year: 2014
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer. ..
  8. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The human T cell lymphotropic virus type 1 (HTLV-1) infects 20 million individuals worldwide and is the causal agent of HTLV-1-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP)...
  9. Louis M Mansky; Fiscal Year: 2015
    ..The results from these proposed studies should provide further insight into fundamental aspects of HTLV-1 and retrovirus particle assembly, which may aid in developing therapeutics. ..
  10. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010
    ..This proposal investigates a novel mechanism of how Tax activates the transcription of a cellular gene important for cell cycle progression that, when overexpressed, potentially contributes to the proliferation of HTLV-1 infected cells. ..
  11. MECHANISM OF HTLV-I TAX-MEDIATED PHOSPHORYLATION OF IKBA
    EMMETT CUNNINGHAM; Fiscal Year: 2000
    ..The candidate plans ultimately to apply the approaches and techniques learned during the five years of the training program to the study of infectious and immune-mediated eye disease. ..
  12. Activation of HTLV1 Gene Expression and Oncogenesis
    Arnold Rabson; Fiscal Year: 2006
    ..by immune activation stimuli; (2) Study the effects of viral LTR sequences and immune activation stimuli on HTLV 1 replication and T-cell transformation; (3) Determine if HTLV-1 lax will cooperate with immune 'activation ..
  13. NEUROLOGIC MANIFESTATIONS OF HTLV-I INFECTION
    King Holmes; Fiscal Year: 2000
    ....
  14. In vivo Imaging of Brain Damage in HTLV-I Associated Tropical Spastic Paraparesis
    Caterina Mainero; Fiscal Year: 2009
    ..Understanding the in vivo pathogenic mechanisms of HAM/TSP-associated brain damage and its neurologic consequences may ultimately lead to more effective therapeutic and preventive interventions of this endemic disorder. ..
  15. Impact of Tax on Dendritic Cell Immunologic Function
    Kate Mostoller; Fiscal Year: 2003
    b>Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of both adult T cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMKSP)...
  16. Mutation selection for immune response to MBP in HAM/TSP
    Mark Allegretta; Fiscal Year: 2003
    ..abstract_text> ..
  17. A TEST FOR HTLV-1 MEDIATED IN VIVO T-CELL EXPANSION
    Mark Allegretta; Fiscal Year: 2000
    ..The test would also have diagnostic/therametric applications in disease conditions where therapeutic agents are used that target the puring salvage pathway. ..
  18. ISABELLE MICHELE LEMASSON; Fiscal Year: 2014
    ..We will test whether abnormal expression of specific genes underlies certain biological aspects of HTLV-1 infection that may relate to development or clinical presentations of ATL. ..
  19. ASSAYS FOR SCREENING HIV-2 AND HLTV-1 ANTIBODIES
    TUNHOU LEE; Fiscal Year: 1993
    ..The possibility of conducting a similar study for HIV-2 will be discussed at a future time with our long-time West African collaborators and will not be in the scope of this proposal...
  20. CONCOMITANT INFECTIONS WITH HIV AND HTLV-I/HTLV-II
    William Hall; Fiscal Year: 1992
    ..Finally we plan a prospective study of the clinical and immunological features of dually infected IVDAs which with specific virus identification may allow a better understanding of their role in human disease...
  21. VIVIANA A SIMON; Fiscal Year: 2014
    ....
  22. Host Cell Determinants and Retroviral Infection
    Ghalib Alkhatib; Fiscal Year: 2003
    DESCRIPTION (Provided by applicant): The human T cell leukemia virus type 1 (HTLV-1) preferentially infects and transforms CD4+ T lymphocytes in vivo and in vitro. The molecular basis underlying this cell tropism is not understood...
  23. ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1
    Michael Lairmore; Fiscal Year: 2003
    Despite advances in the understanding of the in vitro molecular mechanisms of human T cell lymphotropic virus type 1 (HTLV-1), the development of appropriate and coordinated animal model systems to study the virus has not kept pace with ..
  24. Regulation of HTLV-I replication by the viral p30
    Christophe Nicot; Fiscal Year: 2009
    ..abstract_text> ..
  25. Mechanism of HTLV-1 activation of the SRF pathway.
    Maureen Shuh; Fiscal Year: 2006
    ..abstract_text> ..
  26. MOLECULAR MIMICRY IN IMMUNE MEDIATED NEUROLOGIC DISEASE
    Michael Levin; Fiscal Year: 2001
    ..2. Determine the epitope specificity of HAM/TSP IgG for HTLV-I and the neuronal self protein. 3. Determine the specificity of HAM/TSP IgG for neuronal tissue. ..
  27. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..This proposal will provide mechanistic insight into how TAX1BP1, Itch and A20 function together to inactivate key signaling molecules and restrict inflammatory signaling pathways. ..
  28. UTPAL P DAVE; Fiscal Year: 2016
    ..Our aims are well-timed and can have a significant impact on a disease that is universally fatal upon diagnosis and advance our understanding of JAK3's role in T-cell neoplasia. ..
  29. James B Lok; Fiscal Year: 2014
    ..Milestones indicating success in the R33 phase will be three lead compounds that clear hyperchronic S. stercoralis infection. ..
  30. THELMA THEREZINHA GONCALEZ; Fiscal Year: 2014
    ..outcomes include differences in prevalence of transfusion-transmitted infections (HIV, HCV, HBV, syphilis, HTLV I/II, Chagas disease), donor motivations (e.g., test-seeking vs...
  31. XV International Conference on Human Retrovirology: HTLV and Related Viruses
    Edward L Murphy; Fiscal Year: 2011
    ..Approximately 300 scholars from HTLV-endemic regions and international infectious disease research institutions will present their latest data on the molecular virology, immunology, epidemiology and clinical outcomes of HTLV infection. ..
  32. Coordinate Regulation of p53 and c-MYC in an HTLV-1 Model of Carcinogenesis
    Robert L Harrod; Fiscal Year: 2012
    ..This R15 AREA project will provide excellent cancer research training opportunities for undergraduates and graduate students to better prepare them for future careers in the basic or clinical oncological sciences. ..
  33. Recruitment of host noncoding RNAs by XMRV
    Sandra L Wolin; Fiscal Year: 2012
    ..This proposal tests whether the tendency of XMRV and other retroviruses to capture RNA molecules from infected cells can be used to identify new targets for designing antiviral drugs. ..
  34. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..The effects of Tax-induced CREB phosphorylation on HTLV-1 and cyclin D1 transcription represent the major themes of this proposal. ..
  35. HIV induces Gli Proteins to skew naive CD4+ T cells to Th1 and TGF-b effectors
    Christel H Uittenbogaart; Fiscal Year: 2010
    ..The answers to these questions will undoubtedly lead to increased knowledge of viral pathogenesis and general immunology. ..
  36. Modeling HTLV-1 infection and cellular immune response in HLA-A2-transgenic mice
    Zafar K Khan; Fiscal Year: 2012
    ..Additionally the results of these studies will shed light on the dynamics of immune cell interactions during chronic viral infections such as HTLV-1, HIV-1, hepatitis virus and herpes simplex virus. ..
  37. Mechanisms of the Adenovirus E4-ORF1 Oncoprotein
    Ronald T Javier; Fiscal Year: 2013
    ....
  38. Benjamin D Ortiz; Fiscal Year: 2014
    ....
  39. Structural basis for functional modulation of CBP/p300 by the HPV oncoprotein E7
    ARIANE LESLIE JANSMA; Fiscal Year: 2012
    ..Understanding this mechanism has the potential to lead to treatments for viral-induced cancer. ..
  40. Immunomodulatory Function of Human T Cell Leukemia Virus Type 2 (HTLV-2)
    Mark A Beilke; Fiscal Year: 2012
    ..The proposed studies will focus on exploring possible strategies for immune based therapy of HIV infected patients. ..
  41. Edward W Harhaj; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Human T cell leukemia virus type I (HTLV-I) is linked to the genesis of adult T cell leukemia (ATL), an aggressive CD4+ T cell malignancy...
  42. Catarina E Hioe; Fiscal Year: 2015
    ..abstract_text> ..
  43. Host Defense Regulation and Viral Oncogenesis
    Glen N Barber; Fiscal Year: 2013
    ..PROJECT II, William Harrington, Jr., M.D.: Host Defense regulation by HTLV-1. PROJECT III, Enrique Mesri, Ph.D.: HHV8 (KSHV)-Mediated Regulation of Host Defense. ..
  44. Role of viral APH-2 in HTLV-2 replication and persistence
    PATRICK LEE GREEN; Fiscal Year: 2013
    ....
  45. HUNG Y FAN; Fiscal Year: 2014
    ..Meetings in subsequent years will address topics such as Viruses and Intracellular Trafficking, Viral Oncogenes, Viral Latency and Persistence, and Post-transcriptional Regulation of Viral Expression. ..
  46. CHRISTOPHE P NICOT; Fiscal Year: 2015
    ..This project will elucidate the mechanisms employed by Tax to increase genetic instability in pre-tumoral cells and the cellular genes involved in the adaptation/tolerance of DNA damage and transformation. ..
  47. Alisha D Howard; Fiscal Year: 2014
    ..These studies have implications for viral and cellular mechanisms of activation, adding to the generally weak knowledge base on the role of coactivator contribution to this process. ..
  48. Susan J Marriott; Fiscal Year: 2014
    ..The goal of this proposal is to establish a novel mouse transformation model in which the human T cell leukemia virus type I (HTLV-1) Tax oncoprotein is conditionally expressed in T cells, and to use this model to determine ..
  49. TROPICAL INFECTIOUS DISEASE TRAINING GRANT
    Edgar Carvalho; Fiscal Year: 2009
    ....
  50. CHRISTOPHE P NICOT; Fiscal Year: 2014
    ..We will also examine the role of activated Notch in proliferation and inhibition of apoptosis in early phases of HTLV-I infection of T-cells. ..
  51. Lee Ratner; Fiscal Year: 2016
    ..It is expected that the information these physiologically relevant mouse models will identify key target genes that may be inhibited in therapeutic trials of ATLL or other lymphomas. ..
  52. Oliver John Semmes; Fiscal Year: 2016
    ..Successful completion of these studies will help define a novel virus-cell interaction strategy and provide for a better understanding of DDR and cellular transformation. ..
  53. Linking IKKbeta activation to anti-autophagy in viral protein Tax-mediated oncoge
    Hua Cheng; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Adult T cell leukemia/lymphoma (ATLL) is caused by infection with human T cell leukemia virus type 1 (HTLV-1), infecting over 20 million patients worldwide...
  54. Role of miR-124a in HTLV-I oncogenesis
    CHRISTOPHE P NICOT; Fiscal Year: 2012
    ..We will then study the potential cooperation between miR-124a and other microRNA deregulated in HTLV-I transformed cells. Since miR-124a is down regulated in many human cancers, this proposal has the potential for broad implications. ..
  55. Evaluation of RNA transport elements in HIV-1 vectors
    SRINIVAS KUMAR; Fiscal Year: 2007
    ..This, in turn, will allow us to devise high-titer lentivirus-based packaging systems with a reduced chance of generating replication competent virus. ..
  56. TRANSCRIPTION ACTIVATION BY HIV, TAT, HTLV TAX & HBV PX
    Michael Green; Fiscal Year: 2004
    ..However, BEF works by a different mechanism, as a molecular chaperone. Experiments are proposed to further study the mechanism of BEF action. ..
  57. Alteration of Rb in HTLV-1 transformed cells
    Fatah Kashanchi; Fiscal Year: 2005
    ..abstract_text> ..
  58. Modulation of c-MYC Functions in an HTLV-1 Model for Carcinogenesis
    Robert Harrod; Fiscal Year: 2009
    ..These studies may lead to the development of targeted therapeutic strategies to inhibit c-MYC oncogenic functions in hematological malignancies and solid tumors. ..
  59. Molecular analysis of the HTLV-1 Gag L domain
    LOUIS MANSKY; Fiscal Year: 2003
    ..abstract_text> ..
  60. HTLV-I INFECTION AND ATL
    Miguel Suarez; Fiscal Year: 1992
    ....
  61. Mentored Patient-Oriented Research Career Development Aw
    OLUBUMMI AFONJA; Fiscal Year: 2004
    ..Finally, a Phase II clinical trial of 13-cis retinoic acid will be conducted in patients with ATLL. ..
  62. TRANSFORMATION PROPERTIES OF THE HTLV-1 TAX GENE
    RUDY POZZATTI; Fiscal Year: 1992
    ..Once identified these genes will be analyzed to determine what role they may play in the development of a variety of human malignancies. ..
  63. TAX PROTEIN OF HTLV-I--MECHANISM OF ACTION AND ROLE
    Peter Kaufman; Fiscal Year: 1991
    ..Together, these studies should lead to a clearer understanding of the mechanism of tax action and its role in HTLV-I induced leukemogenesis...
  64. Complications of Chronic Viral Infections
    Marshall J Glesby; Fiscal Year: 2012
    ....
  65. ROLE OF MYB IN TRANSCRIPTIONAL-REGULATION OF HIV-1&HTLV1
    E Reddy; Fiscal Year: 1993
    ..Similarly, we will carry out mutagenesis of Myb-binding sites in HTLV-1 LTR and study the effect of these mutations on HTLV-1 LTR mediated transcription...
  66. Studies of p30 II and p13 II in HTLV-1 Infection
    Michael Lairmore; Fiscal Year: 2004
    ....

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