porphyromonas gingivalis

Summary

Summary: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.

Top Publications

  1. doi Detection of oral bacteria in cardiovascular specimens
    K Nakano
    Department of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Oral Microbiol Immunol 24:64-8. 2009
  2. doi Periodontitis: a polymicrobial disruption of host homeostasis
    Richard P Darveau
    University of Washington, Seattle, Washington 98195, USA
    Nat Rev Microbiol 8:481-90. 2010
  3. pmc Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
    George Hajishengallis
    Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
    Cell Host Microbe 10:497-506. 2011
  4. pmc Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis
    R J Lamont
    Department of Oral Biology, University of Washington, Seattle, Washington 98195, USA
    Microbiol Mol Biol Rev 62:1244-63. 1998
  5. pmc Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways
    C Hayashi
    Department of Medicine, Sections of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Oral Microbiol 25:305-16. 2010
  6. pmc Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
  7. ncbi Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis
    Stanley C Holt
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:72-122. 2005
  8. doi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
  9. pmc Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    PLoS ONE 6:e20240. 2011
  10. pmc Comprehensive transcriptome analysis of the periodontopathogenic bacterium Porphyromonas gingivalis W83
    Hedda Høvik
    Department of Oral Biology, University of Oslo, Oslo, Norway
    J Bacteriol 194:100-14. 2012

Research Grants

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
  2. James D Bryers; Fiscal Year: 2016
  3. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
  4. Kim A Brogden; Fiscal Year: 2014
  5. KESAVALU NAIDU LAKSHMYYA; Fiscal Year: 2015
  6. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
  7. MARY ELLEN DAVEY; Fiscal Year: 2016
  8. JAN S POTEMPA; Fiscal Year: 2016
  9. Ozlem Yilmaz; Fiscal Year: 2016
  10. IRINA MARIE VELSKO; Fiscal Year: 2014

Detail Information

Publications322 found, 100 shown here

  1. doi Detection of oral bacteria in cardiovascular specimens
    K Nakano
    Department of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Oral Microbiol Immunol 24:64-8. 2009
    ..To define this relationship, we analyzed the distribution of oral bacterial species in cardiovascular specimens...
  2. doi Periodontitis: a polymicrobial disruption of host homeostasis
    Richard P Darveau
    University of Washington, Seattle, Washington 98195, USA
    Nat Rev Microbiol 8:481-90. 2010
    ..However, several bacterial species found in plaque (the 'red-complex' bacteria: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) use various mechanisms to interfere with host defence ..
  3. pmc Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
    George Hajishengallis
    Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
    Cell Host Microbe 10:497-506. 2011
    b>Porphyromonas gingivalis is a low-abundance oral anaerobic bacterium implicated in periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions. However, the mechanism by which P...
  4. pmc Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis
    R J Lamont
    Department of Oral Biology, University of Washington, Seattle, Washington 98195, USA
    Microbiol Mol Biol Rev 62:1244-63. 1998
    b>Porphyromonas gingivalis, a gram-negative anaerobe, is a major etiological agent in the initiation and progression of severe forms of periodontal disease. An opportunistic pathogen, P...
  5. pmc Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways
    C Hayashi
    Department of Medicine, Sections of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    Mol Oral Microbiol 25:305-16. 2010
    A hallmark of infection with the gram-negative pathogen Porphyromonas gingivalis is the induction of a chronic inflammatory response. P...
  6. pmc Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
    Fimbriae of Porphyromonas gingivalis are filamentous appendages on the cell surface and are thought to be one of the virulence factors...
  7. ncbi Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis
    Stanley C Holt
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:72-122. 2005
  8. doi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
    ..Periodontitis, in which Porphyromonas gingivalis is a major pathogenic bacterium, has been linked to RA in epidemiological studies and also shares similar ..
  9. pmc Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    PLoS ONE 6:e20240. 2011
    ....
  10. pmc Comprehensive transcriptome analysis of the periodontopathogenic bacterium Porphyromonas gingivalis W83
    Hedda Høvik
    Department of Oral Biology, University of Oslo, Oslo, Norway
    J Bacteriol 194:100-14. 2012
    ..RNA sequencing technologies were used to analyze the transcriptome of the periodontopathogenic bacterium Porphyromonas gingivalis. The compiled P...
  11. doi Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen
    Nagihan Bostanci
    Oral Translational Research, Institute of Oral Biology, Center of Dental Medicine, Faculty of Medicine, University of Zurich, Zurich, Switzerland
    FEMS Microbiol Lett 333:1-9. 2012
    b>Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting the tooth, eventually leading to tooth loss...
  12. ncbi IL-8 and IDO expression by human gingival fibroblasts via TLRs
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Henry Dunant Road, Bangkok, Thailand
    J Immunol 178:1151-7. 2007
    ..inflammatory cytokines in response to microbial components such as LPS from the key periodontal pathogen, Porphyromonas gingivalis. In this study, we demonstrated that HGFs expressed mRNA of TLRs 1, 2, 3, 4, 5, 6, and 9, but not TLRs 7, ..
  13. doi Periodontal bacteremia and various vascular diseases
    T Iwai
    Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
    J Periodontal Res 44:689-94. 2009
    ..Serum titer levels of each bacterium are now available and have shown a significant relationship between severity and individual differences...
  14. pmc Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromonas gingivalis
    K Nisapakultorn
    Department of Preventive Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA
    Infect Immun 69:4242-7. 2001
    ..b>Porphyromonas gingivalis was permitted to bind and invade transfected cells expressing calprotectin and sham transfectants...
  15. pmc fimA genotypes and multilocus sequence types of Porphyromonas gingivalis from patients with periodontitis
    Morten Enersen
    Institute of Oral Biology, Faculty of Dentistry, University of Oslo, P O Box 1052, NO 0316 Oslo, Norway
    J Clin Microbiol 46:31-42. 2008
    ..In the periodontal pathogen Porphyromonas gingivalis, the fimA gene is classified into six types (genotypes I, Ib, II, III, IV, and V) on the basis of ..
  16. pmc The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    Dana T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Clin Periodontol 35:89-105. 2008
    ....
  17. pmc Proteomics of Porphyromonas gingivalis within a model oral microbial community
    Masae Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    BMC Microbiol 9:98. 2009
    b>Porphyromonas gingivalis is a periodontal pathogen that resides in a complex multispecies microbial biofilm community known as dental plaque. Confocal laser scanning microscopy showed that P...
  18. doi Differential modulation of human {beta}-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures
    Qian Lu
    The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong
    Innate Immun 15:325-35. 2009
    b>Porphyromonas gingivalis lipopolysaccharide (LPS) is a crucial virulence factor strongly involved in the development of chronic periodontitis...
  19. pmc Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis
    Ana Carolina Monteiro
    Carlos Chagas Filho Institute of Biophysics, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 183:3700-11. 2009
    b>Porphyromonas gingivalis, a Gram-negative bacterium that causes periodontitis, activates the kinin system via the cysteine protease R-gingipain. Using a model of buccal infection based on P...
  20. doi Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling
    Quan Xing
    The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China
    J Cell Physiol 225:106-14. 2010
    Although Porphyromonas gingivalis lipopolysaccharide (P-LPS) is known to inhibit osteoblast differentiation, the exact molecular mechanisms underlying this phenomenon remain unclear...
  21. pmc The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis
    Jorg Brunner
    Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Free University Amsterdam, Amsterdam, The Netherlands
    BMC Microbiol 10:252. 2010
    The Gram negative anaerobic bacterium Porphyromonas gingivalis has long been recognized as a causative agent of periodontitis. Periodontitis is a chronic infectious disease of the tooth supporting tissues eventually leading to tooth-loss...
  22. pmc Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats
    Sandrine Delbosc
    Institut National de la Santé et de la Recherche Médicale U698, Paris, France
    PLoS ONE 6:e18679. 2011
    ..We postulated that neutrophil recruitment and activation participating in AAA growth may originate in part from repeated episodes of periodontal bacteremia...
  23. pmc Porphyromonas gingivalis galE is involved in lipopolysaccharide O-antigen synthesis and biofilm formation
    Ryoma Nakao
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku ku, Tokyo, Japan 162 8640
    Infect Immun 74:6145-53. 2006
    b>Porphyromonas gingivalis is a crucial component of complex plaque biofilms that form in the oral cavity, resulting in the progression of periodontal disease...
  24. pmc Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis
    Mariko Naito
    Division of Microbiology and Oral Infection, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 7 1, Nagasaki, Japan
    DNA Res 15:215-25. 2008
    The gram-negative anaerobic bacterium Porphyromonas gingivalis is a major causative agent of chronic periodontitis...
  25. pmc Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
    M Hirschfeld
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Infect Immun 69:1477-82. 2001
    Lipopolysaccharide (LPS) derived from the periodontal pathogen Porphyromonas gingivalis has been reported to differ structurally and functionally from enterobacterial LPS...
  26. pmc Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis
    R P Darveau
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
    Infect Immun 66:1660-5. 1998
    ..which is widespread in the adult population, is a persistent bacterial infection associated with Porphyromonas gingivalis. Gingival epithelial cells are among the first cells encountered by both P...
  27. ncbi Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
    ..may increase the risk of atherosclerosis and related events in humans, we assessed the impact of oral inoculation with the periodontal pathogen Porphyromonas gingivalis on atherogenesis in hypercholesterolemic apolipoprotein E-null mice.
  28. ncbi Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice
    Frank C Gibson
    Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass, USA
    Circulation 109:2801-6. 2004
    ..Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD...
  29. ncbi Relationship between periodontal infections and systemic disease
    G J Seymour
    Faculty of Dentistry, University of Otago, Dunedin, New Zealand
    Clin Microbiol Infect 13:3-10. 2007
    ..respect to the latter, cross-reactive antibodies and T-cells between self heat-shock proteins (HSPs) and Porphyromonas gingivalis GroEL have been demonstrated in the peripheral blood of patients with atherosclerosis as well as in the ..
  30. ncbi Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model
    Li Li
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Mass 02118, USA
    Circulation 105:861-7. 2002
    ..To test this hypothesis, we investigated the effect of repeated systemic inoculations with Porphyromonas gingivalis (Pg), a putative periodontal pathogen, on the progression of atherosclerosis in heterozygous ..
  31. pmc Genetic transformation of an obligate anaerobe, P. gingivalis for FMN-green fluorescent protein expression in studying host-microbe interaction
    Chul Hee Choi
    Department of Periodontology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e18499. 2011
    ..for the first time that an obligate anaerobe, the successful opportunistic pathogen of the oral cavity, Porphyromonas gingivalis, can be genetically engineered for expression of the non-toxic green FbFP...
  32. ncbi Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis
    Indra Z Mustapha
    Department of Periodontology, Howard University, Washington, DC, USA
    J Periodontol 78:2289-302. 2007
    ..The purpose of this study was to review and analyze the association between PD with elevated systemic bacterial exposure and CVD...
  33. ncbi Genetic diversity of Porphyromonas gingivalis and its possible importance to pathogenicity
    N Ozmeric
    Department of Periodontology and Institute of Oral Biology, Dental Faculty, University of Oslo, Norway
    Acta Odontol Scand 58:183-7. 2000
    ..One of them, Porphyromonas gingivalis, is a putative periodontopathogenic organism considered to be particularly relevant in the etiology of ..
  34. ncbi Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis
    I Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontal Res 37:425-32. 2002
    b>Porphyromonas gingivalis fimbriae are critical for the promotion of bacterial infection. The fimA gene encoding fimbrillin, a subunit of fimbriae, has been classified into five genotypes (types I to V) based on their nucleotide sequences...
  35. pmc Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis
    Daniel Grenier
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada
    Infect Immun 71:4742-8. 2003
    Proteolytic enzymes produced by Porphyromonas gingivalis are thought to play critical roles in the pathogenesis of periodontitis...
  36. ncbi Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles
    Lisa Duncan
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada G1K 7P4
    Microb Pathog 36:319-25. 2004
    b>Porphyromonas gingivalis, the major etiologic agent of chronic periodontitis, produces a broad spectrum of virulence factors, including outer membrane vesicles. In this study, we investigated the capacity of P...
  37. pmc Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4
    Richard P Darveau
    Department of Periodontics, University of Washington, Health Sciences Center, Box 357444, Seattle, WA 98195, USA
    Infect Immun 72:5041-51. 2004
    The innate host response to lipopolysaccharide (LPS) obtained from Porphyromonas gingivalis is unusual in that different studies have reported that it can be an agonist for Toll-like receptor 2 (TLR2) as well as an antagonist or agonist ..
  38. ncbi Occurrence of Porphyromonas gingivalis and Tannerella forsythensis in periodontally diseased and healthy subjects
    Hui Wen Yang
    School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Periodontol 75:1077-83. 2004
    The purpose of this study was to compare the prevalence and level of Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythensis (T...
  39. ncbi Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography
    Asaf Wilensky
    Department of Periodontology, Faculty of Dental Medicine, Hadassah Medical Centers and The Hebrew University, Jerusalem, Israel
    J Periodontol 76:1282-6. 2005
    ..The present study was designed to evaluate a novel method for assessing the volume of alveolar bone loss in mice and to compare it to the traditional morphometric (linear) technique...
  40. ncbi Innate immune signaling and Porphyromonas gingivalis-accelerated atherosclerosis
    F C Gibson
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Evans Biomedical Research Center, Boston, MA 02118, USA
    J Dent Res 85:106-21. 2006
    ....
  41. pmc Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis
    N Sawada
    Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan
    Clin Exp Immunol 148:529-36. 2007
    b>Porphyromonas gingivalis is a Gram-negative anaerobic oral black-pigmented bacterium closely associated with chronic periodontitis. Lipopolysaccharide (LPS) derived from P...
  42. ncbi Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    George Hajishengallis
    Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 179:2359-67. 2007
    ..b>Porphyromonas gingivalis is a major pathogen in periodontal disease and is associated with increased risk of systemic conditions...
  43. ncbi Subgingival microbial profiles in chronic periodontitis patients from Chile, Colombia and Spain
    David Herrera
    ETEP Research Group, Faculty of Dentistry, University Complutense, Madrid, Spain
    J Clin Periodontol 35:106-13. 2008
    ..To investigate the subgingival microbiota of distinct periodontitis patient populations, in Chile, Colombia and Spain, using identical clinical and bacteriological methods...
  44. doi Biological properties of the native and synthetic lipid A of Porphyromonas gingivalis lipopolysaccharide
    H Kumada
    Department of Oral Microbiology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    Oral Microbiol Immunol 23:60-9. 2008
    A pentaacyl and diphosphoryl lipid A molecule found in the lipid A isolated from Porphyromonas gingivalis lipopolysaccharide (LPS) was chemically synthesized, and its characteristics were evaluated to reconfirm its interesting ..
  45. pmc Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?
    George Hajishengallis
    Department of Periodontics Oral Health and Systemic Disease, School of Dentistry, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Microbes Infect 11:637-45. 2009
    This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P...
  46. doi Variable cell responses to P. gingivalis lipopolysaccharide
    L Kocgozlu
    ERT 1061 internal to unit INSERM UMR 977, Dental Faculty, University of Strasbourg, 11 rue Humann, 67000 Strasbourg, France
    J Dent Res 88:741-5. 2009
    b>Porphyromonas gingivalis is a major etiological agent of chronic periodontal diseases, the virulence of which has been attributed to different factors, including lipopolysaccharide (LPS)...
  47. pmc Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment
    Nobumichi Furuta
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 77:4761-70. 2009
    b>Porphyromonas gingivalis, a periodontal pathogen, secretes outer membrane vesicles (MVs) that contain major virulence factors, including proteases termed gingipains (Arg-gingipain [Rgp] and Lys-gingipain [Kgp]). We recently showed that P...
  48. pmc Mutualistic biofilm communities develop with Porphyromonas gingivalis and initial, early, and late colonizers of enamel
    Saravanan Periasamy
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    J Bacteriol 191:6804-11. 2009
    b>Porphyromonas gingivalis is present in dental plaque as early as 4 h after tooth cleaning, but it is also associated with periodontal disease, a late-developing event in the microbial successions that characterize daily plaque development...
  49. doi Porphyromonas gingivalis induces RANKL in T-cells
    Georgios N Belibasakis
    Institute of Oral Biology, Center of Dental and Oral Medicine and Cranio Maxillofacial Surgery, University of Zurich, Plattenstrasse 11, Zurich, Switzerland
    Inflammation 34:133-8. 2011
    b>Porphyromonas gingivalis is an oral pathogen highly implicated in chronic periodontitis, a disease characterized by inflammatory destruction of the tooth-supporting alveolar bone and eventually, tooth loss...
  50. ncbi Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Involvement of Porphyromonas gingivalis in the development of human aortic aneurysm
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    J Pharmacol Sci 113:115-9. 2010
    Accumulating evidence suggests the involvement of Porphyromonas gingivalis (P. gingivalis), a periodontal pathogen, in cardiovascular diseases...
  51. pmc Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses
    Chie Hayashi
    Department of Medicine, Sections of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Innate Immun 2:334-43. 2010
    ..Human and mouse studies support a role for the oral pathogen Porphyromonas gingivalis in atherosclerosis, although the mechanisms by which this pathogen stimulates inflammatory ..
  52. doi Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2
    Yukari Aoki
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Biochem Biophys Res Commun 398:86-91. 2010
    ..It has been demonstrated that fimbrial protein encoded by fimA gene (FimA fimbriae) of Porphyromonas gingivalis not only contributes to the abilities of bacterial adhesion and invasion to host cells, but also strongly ..
  53. pmc Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats
    Brian Bainbridge
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Infect Immun 78:4560-9. 2010
    b>Porphyromonas gingivalis secretes a serine phosphatase enzyme, SerB, upon contact with gingival epithelial cells in vitro. The SerB protein plays a critical role in internalization and survival of the organism in epithelial cells...
  54. doi Presence of periodontopathic bacteria in coronary arteries from patients with chronic periodontitis
    Silvia L Marcelino
    Department of Stomatology, University of Sao Paulo, SP, Brazil
    Anaerobe 16:629-32. 2010
    ..Our results indicate a significant association between the presence of Porphyromonas gingivalis and atheromas, and the periodontal bacteria in oral biofilm may find a way to reach arteries.
  55. pmc The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss
    Shuang Liang
    Center for Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 186:869-77. 2011
    ..However, the periodontal pathogen Porphyromonas gingivalis can control C5aR activation by generating C5a through its own C5 convertase-like enzymatic activity...
  56. pmc Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice
    Chie Hayashi
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, United States
    Atherosclerosis 215:52-9. 2011
    Studies in humans support a role for the oral pathogen Porphyromonas gingivalis in the development of inflammatory atherosclerosis. The goal of this study was to determine if P...
  57. pmc Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease
    Takayasu Watanabe
    Section of Bacterial Pathogenesis, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Bacteriol 193:4259-60. 2011
    b>Porphyromonas gingivalis is a black-pigmented asaccharolytic anaerobe and a major causative agent of periodontitis. Here, we report the complete genome sequence of P...
  58. ncbi Effect of melatonin on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis
    Yukio Murakami
    Division of Oral Diagnosis, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado City, Saitama 350 0283, Japan
    In Vivo 25:641-7. 2011
    ..In the present study, COX-2 expression and NF-κB activation in RAW264.7 macrophage-like cells stimulated with the fimbriae of Porphyromonas gingivalis, an oral anaerobe, in the absence and presence of melatonin were investigated.
  59. doi Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts
    Thanuja D K Herath
    Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    J Clin Periodontol 38:694-701. 2011
    b>Porphyromonas gingivalis lipopolysaccharide (LPS) displays a significant amount of structural heterogeneity, containing both tetra- (LPS(1435/1449) ) and penta-acylated (LPS(1690) ) lipid A structures...
  60. doi Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice
    Andrew J Kinloch
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:3818-23. 2011
    To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized by antibodies to citrullinated α-enolase is mediated by Porphyromonas gingivalis enolase in the context of DR4 alleles.
  61. doi Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts
    Liu Die
    Sichuan University, State Key Laboratory of Oral Disease, West China College of Stomatology, 14 Renminnan Road, Chengdu 610041, Sichuan, China
    Mol Immunol 52:38-49. 2012
    ..expression of CD40, as well as production of pro-inflammatory cytokines IL-6, TNF-α and IL-1β, in the Porphyromonas gingivalis-lipopolysaccharide (LPS)-stimulated murine osteoblastic-like MC3T3-E1 cells...
  62. pmc Selective sorting of cargo proteins into bacterial membrane vesicles
    M Florencia Haurat
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    J Biol Chem 286:1269-76. 2011
    ..Here we establish that the human oral pathogen Porphyromonas gingivalis has a mechanism to selectively sort proteins into OMV, resulting in the preferential packaging of ..
  63. doi Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease
    Toshiaki Ara
    Department of Pharmacology, Matsumoto Dental University, Gobara, Hirooka, Shiojiri, Japan
    J Periodontal Res 44:21-7. 2009
    ....
  64. pmc Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells
    Mary Khlgatian
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 70:257-67. 2002
    b>Porphyromonas gingivalis is an oral pathogen that has recently been associated with chronic inflammatory diseases such as atherosclerosis. The strength of the epidemiological associations of P...
  65. ncbi Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis
    Emil V Kozarov
    Arterioscler Thromb Vasc Biol 25:e17-8. 2005
  66. pmc Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization
    Takanari Miyamoto
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Evans Biomedical Research Center, Room 637, 650 Albany St, Boston, MA 02118, USA
    Infect Immun 74:1376-80. 2006
    Here we report on early inflammatory events associated with Porphyromonas gingivalis-accelerated atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice. Animals challenged with P...
  67. pmc Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease
    Lakshmyya Kesavalu
    Department of Periodontology, College of Dentistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32611, USA
    Infect Immun 75:1704-12. 2007
    One of the predominant polymicrobial infections of humans is expressed clinically as periodontal disease. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly implicated as members of a pathogenic ..
  68. pmc Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50
    Minnie Rangarajan
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 190:2920-32. 2008
    We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance...
  69. doi Prevalence and distribution of principal periodontal pathogens worldwide
    Mette Rylev
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Clin Periodontol 35:346-61. 2008
    ..There is evidence that some evolutionary lineages of bacteria have adapted to particular ethnic groups...
  70. pmc Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments
    Nobumichi Furuta
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 77:4187-96. 2009
    b>Porphyromonas gingivalis, a periodontal pathogen, secretes outer membrane vesicles (MVs) that contain major virulence factors, including major fimbriae and proteases termed gingipains, although it is not confirmed whether MVs enter host ..
  71. doi Periodontitis in RA-the citrullinated enolase connection
    Karin Lundberg
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London W6 8LH, UK
    Nat Rev Rheumatol 6:727-30. 2010
    ..and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection...
  72. pmc Enhanced biofilm formation and loss of capsule synthesis: deletion of a putative glycosyltransferase in Porphyromonas gingivalis
    Mary E Davey
    Department of Molecular Genetics, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
    J Bacteriol 188:5510-23. 2006
    Periodontitis is a biofilm-mediated disease. Porphyromonas gingivalis is an obligate anaerobe consistently associated with severe manifestations of this disease...
  73. pmc LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways
    Xiaoren Tang
    Department of Periodontology, Boston University Medical Center, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 103:13777-82. 2006
    ..Using these cells, we now show that LITAF expression can be induced after challenge either with LPS from Porphyromonas gingivalis via agonism at TLR-2, or with LPS from Escherichia coli via agonism at TLR-4, both requiring functional ..
  74. ncbi Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review
    Andrea Mombelli
    School of Dental Medicine, University of Geneva, Switzerland
    J Clin Periodontol 29:10-21; discussion 37-8. 2002
    ..The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis...
  75. ncbi Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
    M Okamoto
    Department of Oral Bacteriology, Tsurumi University School of Dental Medicine, Kanagawa, Japan
    Oral Microbiol Immunol 19:118-20. 2004
    ..of catechins and their derivatives on the activities of Arg-gingipain (Rgp) and Lys-gingipain (Kgp) in Porphyromonas gingivalis. Catechin derivatives, which included (-)-epigallocatechin gallate, (-)-epicatechin gallate, (-)-..
  76. ncbi Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae
    Kazuhiko Maeda
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 6:1163-70. 2004
    Interaction of Porphyromonas gingivalis with plaque-forming bacteria is necessary for its colonization in periodontal pockets. Participation of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and P...
  77. pmc Protease-activated receptor 2 mediates human beta-defensin 2 and CC chemokine ligand 20 mRNA expression in response to proteases secreted by Porphyromonas gingivalis
    Henrik Dommisch
    Department of Oral Biology, School of Dentistry, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    Infect Immun 75:4326-33. 2007
    The oral pathogen Porphyromonas gingivalis secretes proteases such as Arg-gingipain B (RgpB) that activate protease-activated receptors (PARs)...
  78. pmc ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis
    Ozlem Yilmaz
    Department of Periodontology, University of Florida, Gainesville, FL 32610, USA
    Cell Microbiol 10:863-75. 2008
    ..b>Porphyromonas gingivalis, an intracellular bacterium and successful colonizer of oral tissues, can inhibit gingival epithelial ..
  79. ncbi Glycosylation of the OMP85 homolog of Porphyromonas gingivalis and its involvement in biofilm formation
    Ryoma Nakao
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 365:784-9. 2008
    ..We studied an uncharacterized OMP85 homolog of Porphyromonas gingivalis, a primary periodontal pathogen forming subgingival plaque biofilms...
  80. pmc The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay
    Ozlem Yilmaz
    Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Microbiology 154:2897-903. 2008
    ..b>Porphyromonas gingivalis, an aetiological agent in severe forms of periodontitis (a chronic inflammatory disease), is a prominent ..
  81. pmc Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis
    Deborah E Dietrich
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 76:5714-20. 2008
    ..Here we determine if HNPs and HBDs bind to the immobilized adhesins of Porphyromonas gingivalis strain 381, recombinant hemagglutinin B (rHagB) and recombinant fimbrillin A (rFimA), by surface plasmon ..
  82. doi Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells
    Max Tze Han Huang
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 182:2395-404. 2009
    ..S. alone. The oral pathogen Porphyromonas gingivalis causes inflammatory host response leading to periodontal and other secondary inflammatory diseases...
  83. pmc Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide
    H E Barksby
    Periodontal Immunobiology Research Group, School of Dental Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Exp Immunol 156:479-87. 2009
    b>Porphyromonas gingivalis lipopolysaccharide (LPS) (strain W50) interacts with Toll-like receptor 2 (TLR-2) leading to cytokine expression and inflammation, and thereby plays a key role in the pathogenesis of periodontal disease...
  84. pmc Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Antimicrob Agents Chemother 53:3308-16. 2009
    ..vitro effects of LF-related agents on the growth and biofilm formation of two periodontopathic bacteria, Porphyromonas gingivalis and Prevotella intermedia, which reside as biofilms in the subgingival plaque. The planktonic growth of P...
  85. pmc ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis
    Ozlem Yilmaz
    Department of Periodontology, University of Florida, Gainesville, FL 32610, USA
    Cell Microbiol 12:188-98. 2010
    ..Treatment of GECs with LPS or infection with the periodontal pathogen, Porphyromonas gingivalis, induced expression of the il-1beta gene and intracellular accumulation of IL-1beta protein...
  86. doi Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata 951 8514, Japan
    J Vasc Res 47:346-54. 2010
    ..However, it is not known whether periodontal infection affects the expression of Egr-1 and subsequent endothelial cells expression of monocyte chemoattractant protein (MCP)-1, a key molecule of leukocyte chemoattraction into vessels...
  87. pmc Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells
    L Yao
    Department of Periodontology and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Oral Microbiol 25:89-101. 2010
    b>Porphyromonas gingivalis, a self-limiting oral pathogen, can colonize and replicate in gingival epithelial cells (GECs). P...
  88. pmc A Porphyromonas gingivalis mutant defective in a putative glycosyltransferase exhibits defective biosynthesis of the polysaccharide portions of lipopolysaccharide, decreased gingipain activities, strong autoaggregation, and increased biofilm formation
    Mikiyo Yamaguchi
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Infect Immun 78:3801-12. 2010
    The Gram-negative anaerobic bacterium Porphyromonas gingivalis is a major pathogen in periodontal disease, one of the biofilm-caused infectious diseases...
  89. doi The outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis
    Yu Yen Chen
    Oral Health Cooperative Research Centre, Melbourne Dental School, and Bio21 Institute, The University of Melbourne, VIC 3010, Australia
    Mol Microbiol 79:1380-401. 2011
    Protein substrates of a novel secretion system of Porphyromonas gingivalis contain a conserved C-terminal domain (CTD) essential for secretion and attachment to the cell surface...
  90. pmc Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    Juhi Bagaitkar
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 5:e9323. 2010
    ..gingivalis...
  91. ncbi Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells
    J D Rudney
    Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis, 55455, USA
    J Dent Res 84:59-63. 2005
    ..and confocal microscopy to detect the periodontal pathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis within buccal epithelial cells taken directly from the mouth...
  92. doi Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response
    Lindsey C Pingel
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Cell Biol 86:643-9. 2008
    ..pro-inflammatory cytokine responses to recombinant hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis strain 381...
  93. pmc Distinct roles of long/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis
    Masae Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    BMC Microbiol 9:105. 2009
    b>Porphyromonas gingivalis, a periodontal pathogen, expresses a number of virulence factors, including long (FimA) and short (Mfa) fimbriae as well as gingipains comprised of arginine-specific (Rgp) and lysine-specific (Kgp) cysteine ..
  94. pmc Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis
    Deanne L Pierce
    Department of Periodontics Oral Health and Systemic Disease, University of Louisville School of Dentistry, Kentucky 40292, USA
    Infect Immun 77:3294-301. 2009
    The fimbriae of Porphyromonas gingivalis mediate critical roles in host colonization and evasion of innate defenses and comprise polymerized fimbrilin (FimA) associated with quantitatively minor accessory proteins (FimCDE) of unknown ..
  95. pmc Porphyromonas gingivalis strain diversity
    Christina O Igboin
    Division of Oral Biology, College of Dentistry, Ohio State University, Columbus, OH 43210, USA
    J Clin Microbiol 47:3073-81. 2009
    b>Porphyromonas gingivalis is implicated in the etiology of chronic periodontitis. Genotyping studies suggest that genetic variability exists among P...
  96. pmc Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque [corrected] and in dental plaque samples
    Kazuyuki Ishihara
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan
    J Clin Microbiol 42:1313-5. 2004
    Utilizing PCR, the 16S rRNA detection rates for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Treponema denticola, and Campylobacter rectus in samples of stenotic coronary artery plaques were ..
  97. ncbi Ferritin from the obligate anaerobe Porphyromonas gingivalis: purification, gene cloning and mutant studies
    D B Ratnayake
    Department of Microbiology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Microbiology 146:1119-27. 2000
    b>Porphyromonas gingivalis is an obligate anaerobe that utilizes haem, transferrin and haemoglobin efficiently as sources of iron for growth, and has the ability to store haem on its cell surface, resulting in black pigmentation of colonies ..
  98. ncbi Prevalence of Bacteroides forsythus, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in subgingival microflora of Japanese patients with adult and rapidly progressive periodontitis
    K Yano-Higuchi
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Japan
    J Clin Periodontol 27:597-602. 2000
    This study investigated the prevalence of Bacteroides forsythus, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among various periodontitis patients and healthy individuals in Japan, and correlated it with clinical ..
  99. ncbi The sensitivity of Porphyromonas gingivalis and Fusobacterium nucleatum to different (pseudo)halide-peroxidase combinations compared with mutans streptococci
    R Ihalin
    Institute of Dentistry, Turku Immunology Centre and TuBS, University of Turku, Finland
    J Med Microbiol 50:42-8. 2001
    ..and thiocyanate in combinations with lactoperoxidase (LP) and myeloperoxidase (MP) on the viability of Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus mutans and S. rattus were analysed...
  100. pmc Interactions of Porphyromonas gingivalis with oxyhaemoglobin and deoxyhaemoglobin
    John W Smalley
    Unit of Oral Biology, The Edwards Building, Department of Clinical Dental Sciences, University of Liverpool, Daulby Street, Liverpool L69 3GN, U K
    Biochem J 362:239-45. 2002
    When grown on blood-containing solid media, the anaerobic periodontal pathogen Porphyromonas gingivalis produces a haem pigment, the major component of which is the mu-oxo bishaem of iron protoporphyrin IX [Smalley, Silver, Marsh and ..
  101. ncbi Detection of Porphyromonas gingivalis DNA in aortic tissue by PCR
    Michael Stelzel
    Department of Periodontology, University of Marburg, Germany
    J Periodontol 73:868-70. 2002
    ..Periodontopathogens may play a role in the etiology of cardiovascular disease. The aim of the present study was to investigate biopsies of aortic tissue for the presence of periodontopathogens...

Research Grants72

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..to inhibit inflammatory events relevant to periodontal diseases in vitro, including biofilm formation by Porphyromonas gingivalis, cytokine production by LPS- or AGE-stimulated human monocyte/macrophages, matrix metalloproteinase ..
  2. James D Bryers; Fiscal Year: 2016
    ..Persistence of Porphyromonas gingivalis in subgingival plaque from periodontitis patients after treatment (scaling and root planing) has been ..
  3. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
    ..Bacteria like Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter (Actinobacillus) actinomycetemcomitans, Tannerella forsythia and ..
  4. Kim A Brogden; Fiscal Year: 2014
    ..is tested using recombinant hemagglutinin B (rHagB) and recombinant Fimbrillin (rFimA), two adhesins from Porphyromonas gingivalis. This application brings together investigators whose long-term goals are to increase understanding of ..
  5. KESAVALU NAIDU LAKSHMYYA; Fiscal Year: 2015
    ..Several studies have detected the presence of periodontal bacterial genomic DNA (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Aggregator actinomycetemcomitans, Campylobacter rectus, ..
  6. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..effects of other early colonizers such as Actinomyces naeslundii and later anaerobic colonizers such as Porphyromonas gingivalis on quorum-sensing in S...
  7. MARY ELLEN DAVEY; Fiscal Year: 2016
    ..of anaerobic bacteria in the subgingival crevice is central to progression of this chronic disease, with Porphyromonas gingivalis being implicated as one of the primary pathogens...
  8. JAN S POTEMPA; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of tissues that support the teeth...
  9. Ozlem Yilmaz; Fiscal Year: 2016
    ..b>Porphyromonas gingivalis is a gram (-) anaerobe and a major etiological agent in severe forms of the disease...
  10. IRINA MARIE VELSKO; Fiscal Year: 2014
    ..Four of these select species are Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tanerella forsythia (Tf) and Fusobacterium nucleatum (Fn)...
  11. Dominique S Michaud; Fiscal Year: 2015
    ..in risk of pancreatic cancer among individuals with high levels of antibodies to a pathogenic strain of Porphyromonas gingivalis (OR = 2.38, 95% CI =1.16-4.90, comparing >200 ng/ml vs. <200ng/ml)...
  12. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..Human pathogens such as HIV-1, Mycobacterium tuberculosis, Helicobacter pylori and Porphyromonas gingivalis are able to infect DCs and disrupt DC maturation, leading to immunosuppression...
  13. Minor fimbriae of P. gingivalis and dendritic cells
    AMIR EMANUEL ZEITUNI; Fiscal Year: 2010
    ..by applicant): The broad objective of this proposal is to elucidate the specific interactions between Porphyromonas gingivalis (P. gingivalis) and dendritic cells (DCs). P...
  14. Antimicrobial Lipids within the Oral Cavity
    PHILIP WESLEY WERTZ; Fiscal Year: 2010
    ..phytosphingosine and 6-hydroxysphingosine) against selected strains of the periodontal pathogens Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. 3...
  15. Counteracting microbial immune evasion for the treatment of periodontitis
    MEGAN LAVONNE MCINTOSH; Fiscal Year: 2012
    ..Among those microbes, Porphyromonas gingivalis stands as a primary contributor to pathology, significantly via its ability to interact with and ..
  16. Porphyromonas gingivalis Horizontal DNA Transfer and Genetic Variation
    Gena D Tribble; Fiscal Year: 2013
    ..b>Porphyromonas gingivalis is a Gram-negative anaerobe that colonizes plaque biofilms in the human subgingival crevice, and is a ..
  17. Inhibition of oral bacterial biofilm formation using natural products-inspired or
    NATHANIEL CHARLES CADY; Fiscal Year: 2012
    ..mutans or Porphyromonas gingivalis that lead to tooth decay and oral disease...
  18. Massimo Costalonga; Fiscal Year: 2014
    ..objective is to study the kinetics of activation and phenotype of CD4+ effector T cells specific for two Porphyromonas gingivalis gingipains (RgpA and Kgp) in a mouse strain susceptible (BALB/c) or resistant (C57BL/6) to P...
  19. Elizabeth Scisci; Fiscal Year: 2015
    ..The outcome of DC-PMN interaction may depend to a large extent on the type of pathogen encountered. Porphyromonas gingivalis resists phagocytosis by PMNs...
  20. VICTORIA NANETTE STONE; Fiscal Year: 2015
    ..Clinical evidence suggests that Porphyromonas gingivalis plays a significant role in the progression of the disease, expressing numerous virulence factors that ..
  21. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2012
    ..induced obesity they display a dramatic and reproducibly attenuated proinflammatory cytokine profile in a Porphyromonas gingivalis (P.g)-dependent model of periodontal disease, in contrast to lean mice fed a standard chow diet...
  22. Social Stress Modulates Neuropeptide Y in a Model fo Periodontal Inflammation
    BRENDA FAYE READER; Fiscal Year: 2013
    ..b>Porphyromonas gingivalis (P...
  23. Huizhi Wang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis (P. gingivalis) is a Gram-negative anaerobic bacterium and a causative agent of periodontitis. Studies assessing the host inflammatory response to P...
  24. TYPE II Enterotoxins as Mucosal Immunomodulators
    Terry D Connell; Fiscal Year: 2011
    ..capacity of LTIIb( T13I), LT-IIb-B5, and admixtures as adjuvants to enhance protection against pathogens [Porphyromonas gingivalis, Mycobacterium tuberculosis, Streptococcus pneumoniae] which infect different compartments (oral, ..
  25. Innate Immune Bacterial Recognition and Osteoclastogenesis
    Caroline A Genco; Fiscal Year: 2010
    ..inflammatory bone destructive disease induced by bacterial infection with the Gram-negative pathogen Porphyromonas gingivalis. The cellular composition of inflammatory bone lesions in human periodontal disease consists of T and B ..
  26. BACTERIAL PROTEINASES IN PERIODONTAL DISEASE
    JAN S POTEMPA; Fiscal Year: 2012
    ..good oral health becomes dominated by several Gram-negative, anaerobic bacterial species, among which, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola constitute the so called "red complex" of microorganisms ..
  27. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
    ..Specific Aim 4: Determine the role of SHIP1 and TREM2/DAP12 in response to Porphyromonas gingivalis (P. gingivalis) induced alveolar bone loss...
  28. Mechanisms for adaptation to oxidative stress in Porphyromonas gingivalis
    Hansel M Fletcher; Fiscal Year: 2013
    Mechanisms for adaptation to oxidative stress in Porphyromonas gingivalis Porphyromonas gingivalis, a black-pigmented, Gram-negative anaerobe, is an important etiologic agent of periodontal disease...
  29. Janina P Lewis; Fiscal Year: 2016
    ..b>Porphyromonas gingivalis, a periodontopathogen, is well known for its high tolerance of nitrosative stress...
  30. Richard J Lamont; Fiscal Year: 2016
    ..deposition provides an attachment substrate for colonization by potentially pathogenic organisms such as Porphyromonas gingivalis and the fungus Candida albicans, which is the cause of most yeast infections in humans...
  31. Hansel M Fletcher; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is an important etiologic agent of periodontal disease...
  32. Small non-coding RNAs in Porphyromonas gingivalis
    JANINA P contact LEWIS; Fiscal Year: 2010
    b>Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a recognized periodontopathogen...
  33. Salomon Amar; Fiscal Year: 2016
    ..the role of infection-sensing circuits and ensuing inflammatory cytokine expression in a mouse model of Porphyromonas gingivalis (P.g)-associated atherogenesis. Pertinent to this competing application, we evaluated the role of P...
  34. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2011
    ..interactions, these concepts will be investigated in the context of periodontitis and the model pathogen Porphyromonas gingivalis. P...
  35. David A Scott; Fiscal Year: 2014
    ..susceptibility to periodontitis;are more likely to be infected with the key periodontal pathogen Porphyromonas gingivalis;and to harbor higher numbers of this bacterial species relative to non-smokers...
  36. GEORGIOS HAJISHENGALLIS; Fiscal Year: 2016
    ..However, successful microbial pathogens, such as the periodontopathogen Porphyromonas gingivalis, have evolved mechanisms which proactively manipulate the innate immune response...
  37. Frank C Nichols; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is a periodontal pathogen implicated in the initiation and progression of chronic periodontitis in adults...
  38. FREDERICK ANTHONY LUZZIO; Fiscal Year: 2016
    ..Although several organisms have been identified as periodontal pathogens, a recent study suggests that Porphyromonas gingivalis may be a "keystone" pathogen that disrupts host-microbe homeostasis by inducing populational changes in ..
  39. Comprehensive transcriptome analysis for Porphyromonas gingivalis
    Tsute Chen; Fiscal Year: 2009
    ..goal of this application is to define the transcriptome for one of the most studied oral pathogen Porphyromonas gingivalis. Three specific aims are proposed to achieve this goal. Aim 1- Define transcriptome profiling of P...
  40. Connexin-Mediated Hemichannel Activity in Experimental Periodontitis
    Karen F Ross; Fiscal Year: 2012
    ..In preliminary experiments, we have shown that Porphyromonas gingivalis potentiates hemichannel opening in oral epithelial cells, an immediate response to fluid movement above ..
  41. Invasive Bacteria Accelerate Atherosclerosis through TLRs
    Caroline A Genco; Fiscal Year: 2010
    Accumulating evidence has implicated specific infectious agents, including Chlamydia pneumoniae and Porphyromonas gingivalis in the progression of atherosclerosis...
  42. Richard J Lamont; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is considered to be one of the major etiologic agents of periodontal diseases. Studies assessing the host inflammatory response to P...
  43. Caroline A Genco; Fiscal Year: 2016
    ..A hallmark of chronic infection with the oral pathogen, Porphyromonas gingivalis, is the induction of a chronic inflammatory response...
  44. Murray Hackett; Fiscal Year: 2014
    ..The phenotype of the mutants in community development and responses to epithelial cells will further elucidate functional meaning and biological relevance. ..
  45. Host Response to Challenge with Porphyromonas gingivalis DNA
    CHEYANNE ELIZABETH WARREN; Fiscal Year: 2012
    ..gingivalis W83. These studies may then reveal potential targets for preventing the initiation of periodontal disease. ..
  46. Interferon Regulatory Factors and Periodontal Disease
    Frank C Gibson; Fiscal Year: 2012
    ..by applicant): Inflammation elicited by a subset of bacteria that inhabit the oral cavity such as Porphyromonas gingivalis (Pg) is a key facet of periodontal disease (PD)...
  47. Investigation of the role of AI-2 in the development of dental plaque biofilms
    ALEXANDER HAMMOND RICKARD; Fiscal Year: 2010
    ..If able to integrate, pathogens such as Porphyromonas gingivalis and Aggregatibacter (Actinobacillus) actinomycetemcomitans can rapidly divide and overcome the commensal ..
  48. Inhibition of P. gingivalis Biofilm Formation by a Streptococcal Effector Protein
    Carla Cugini; Fiscal Year: 2013
    ..an extracellular arginine deiminase (ADI) produced by oral streptococci that acts on the oral pathogen Porphyromonas gingivalis, inhibiting its biofilm formation and expression of virulence determinants...
  49. BRIAN ANDREW KLEIN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis, an anaerobic, Gram-negative bacterium, is an important organism in the pathogenesis of periodontitis...
  50. CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2014
    ..We think that this may be due to the ability of the bacterial species Porphyromonas gingivalis to infect the gums and evade or suppress the immune system...
  51. Identification of a novel signaling network in Porphyromonas gingivalis
    Hua Xie; Fiscal Year: 2012
    ..Findings from this work should provide new opportunities to design drugs to interfere with initiation and formation of the P. gingivalis biofilms. ..
  52. Ping Xu; Fiscal Year: 2016
    ..between pioneering colonizers (such as mitis group streptococci, MGS) and pathogenic species (such as Porphyromonas gingivalis or Fusobacterium nucleatum), are important for periodontal diseases...
  53. Training in Systems Biology for the Study of Host-Pathogen Interactions
    Mark C Herzberg; Fiscal Year: 2009
    ..Conversely, oral pathogens like Porphyromonas gingivalis cause local infections of the supporting structures of the teeth, yet are swallowed but fail to cause ..
  54. Andrew J Henderson; Fiscal Year: 2014
    ..immunity and enhanced host sensitivity to periodontal pathogens, such as the anaerobic bacterium Porphyromonas gingivalis. We are proposing to employ tissue resident macrophages from the oral cavity, specifically palatine ..
  55. RICHARD PETERS DARVEAU; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is an important gram-negative periopathogen strongly associated with adult type periodontitis. P...
  56. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..Three bacterial species (Porphyromonas gingivalis, Treponema denticola, Bacteroides forsythus) have been shown to be closely associated with chronic ..
  57. Heike Boisvert; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis (Pg), a Gram negative anaerobe is part of a destructive biofilm found in the oral cavity. There Pg interacts with other bacteria and host cells lining the gingival sulcus...
  58. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    ..proteins from the outer membranes of the dental pathogens Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, and from Shigella enteric pathogens...
  59. Molecular mechanisms of the innate regulation of osteoclastogenesis.
    Ping Zhang; Fiscal Year: 2013
    ..b>Porphyromonas gingivalis (Pg) is considered a major etiologic agent of periodontitis...
  60. COMPETITION FOR HEME AMONG PERIODONTAL BACTERIA
    GEOFFREY TOMPKINS; Fiscal Year: 1993
    ..be isolated from relatively healthy gingivae (albeit in low relative numbers) whereas the more pathogenic Porphyromonas gingivalis is rarely found in either healthy or mildly inflamed gingivae but is highly associated with some forms of ..
  61. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    ..One complex, determined the "red complex," consisting of Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola appears to be a major etiologic contributor to the common adult forms of ..
  62. Biofilm Architecture of Subgingival Plaque
    Renate Lux; Fiscal Year: 2009
    ..g. oral treponemes, Fusobacterium ssp., Porphyromonas gingivalis, Tannerella forsythia, Filifactor alocis, TM7 complex) using specific FISH probes...
  63. In situ analysis of bacterial biosynthetic activity in subgingival plaque
    Gerard A Cangelosi; Fiscal Year: 2012
    ..We hypothesize that active cell division of potential pathogens such as Porphyromonas gingivalis correlates with periodontal disease progression at specific sites...
  64. NEURAL NETWORK MODELING OF SPEECH PRODUCTION
    Frank Guenther; Fiscal Year: 2000
    ..as an iron source has been documented for several pathogenic bacteria, including the periodontopathogen, Porphyromonas gingivalis. We have previously determined that P...
  65. QUORUM SENSING AND PERIODONTAL PATHOGENS
    Luciano Passador; Fiscal Year: 1999
    ..The involvement of specific gram negative bacteria such as Prevotella intermedia, Porphyromonas gingivalis, Treponema denticola, and Actinobacillus actinomycetemcomitans, and the role of some of the specific ..
  66. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2005
    ..AgP is associated with neutrophil functional defects and infection by A. actinomycetemcomitans and Porphyromonas gingivalis. Recently genetic sequencing of the formyl peptide receptor from African Americans indicated that ..
  67. P GINGIVALIS VIRULENCE--MOLECULAR GENETIC ANALYSIS
    HOWARD KURAMITSU; Fiscal Year: 2001
    The periodontopathic microorganism Porphyromonas gingivalis expresses a number of potential virulence factors including cysteine proteases and hemagglutinins...
  68. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    ..may be possible since the disease is caused by a small group of gram-negative bacteria among which Porphyromonas gingivalis predominates...
  69. Vascular Tissue Invasion by Porphyromonas gingivalis
    Ling Li; Fiscal Year: 2005
    DESCRIPTION: Porphyromonas gingivalis (P. g.), a Gram-negative anaerobe is known to play a critical role in the development of periodontitis...
  70. Periodontal Inflammation in Type 1 Diabetes
    Thomas Van Dyke; Fiscal Year: 2002
    ..have established that normal patients with periodontal disease mount a strong antibody response to Porphyromonas gingivalis, the primary etiological agent associated with periodontal disease, and in particular to the cysteine ..
  71. SPIROCHETES INDICATE SUSCEPTIBILITY TO PERIODONTITIS
    Michael Meredith; Fiscal Year: 2004
    ..b>Porphyromonas gingivalis, Prevotella intermedia, Treponema amylovorum, T. denticola, T. maltophilum, T. medium, T. pectinovorum, T...
  72. FIBRONECTIN RECEPTOR MEDIATED ADHESION OF P GINGIVALIS
    KAREN SNAPP; Fiscal Year: 1993
    ..b>Porphyromonas gingivalis is a gram negative obligate anaerobe that is commonly isolated from periodontal pockets...