Genomes and Genes
Summary: The physiological renewal, repair, or replacement of tissue.
Publications468 found, 100 shown here
- Adult cardiac stem cells are multipotent and support myocardial regenerationAntonio P Beltrami
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
Cell 114:763-76. 2003..is mainly composed of terminally differentiated cells, but is not a terminally differentiated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair.
- Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic statesRonald D Cohn
McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
Nat Med 13:204-10. 2007..Here we show that increased TGF-beta activity leads to failed muscle regeneration in fibrillin-1-deficient mice...
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheToshiro Sato
Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 459:262-5. 2009..We conclude that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche...
- Wound healing--aiming for perfect skin regenerationP Martin
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Science 276:75-81. 1997..these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
- Cellular and molecular regulation of muscle regenerationSophie B P Chargé
Ottawa Health Research Institute, Ottawa, Ontario, Canada
Physiol Rev 84:209-38. 2004..In addition, recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process...
- The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewalBin Zhao
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
Nat Cell Biol 13:877-83. 2011Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a critical role for the Hippo tumour-suppressor pathway in the regulation of organ ..
- Collective cell migration in morphogenesis, regeneration and cancerPeter Friedl
Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Nat Rev Mol Cell Biol 10:445-57. 2009..Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research...
- Generation of a functional mammary gland from a single stem cellMark Shackleton
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nature 439:84-8. 2006..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
- Substrate elasticity regulates skeletal muscle stem cell self-renewal in cultureP M Gilbert
Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 329:1078-81. 2010..that mimic the elasticity of muscle (12 kilopascals) self-renew in vitro and contribute extensively to muscle regeneration when subsequently transplanted into mice and assayed histologically and quantitatively by noninvasive ..
- Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regenerationDaniel E Wagner
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology MIT, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 332:811-6. 2011..Whether regeneration is accomplished by pluripotent cells or by the collective activity of multiple lineage-restricted cell types is ..
- Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerBaozhi Chen
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nat Chem Biol 5:100-7. 2009..The signal transduction mechanisms shown here to be chemically tractable additionally contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals...
- Telocytes in human skin--are they involved in skin regeneration?Laura Ceafalan
Molecular Medicine Laboratory, V Babeş National Institute of Pathology, Bucharest, Romania
J Cell Mol Med 16:1405-20. 2012..In conclusion, based on TC distribution and intercellular connections, our results suggested that TCs might be involved in skin homeostasis, skin remodelling, skin regeneration and skin repair.
- Investigation of multipotent postnatal stem cells from human periodontal ligamentByoung Moo Seo
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Lancet 364:149-55. 2004..We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue...
- Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell nicheCharlotte A Collins
Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Cell 122:289-301. 2005..into radiation-ablated muscles and demonstrate that satellite cells are self-sufficient as a source of regeneration. As few as seven satellite cells associated with one transplanted myofiber can generate over 100 new myofibers ..
- Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardiumLeora B Balsam
Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 428:668-73. 2004Under conditions of tissue injury, myocardial replication and regeneration have been reported...
- Generation and regeneration of cells of the liver and pancreasKenneth S Zaret
Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Science 322:1490-4. 2008..Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic beta cells in the therapeutic ..
- Functional screening identifies miRNAs inducing cardiac regenerationAna Eulalio
Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy
Nature 492:376-81. 2012..of the minimal renewal of cardiomyocytes during adult life, repair of cardiac damage through myocardial regeneration is very limited...
- Advances in understanding tissue regenerative capacity and mechanisms in animalsKenneth D Poss
Department of Cell Biology, Howard Hughes Medical Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
Nat Rev Genet 11:710-22. 2010Questions about how and why tissue regeneration occurs have captured the attention of countless biologists, biomedical engineers and clinicians...
- Wound repair and regenerationGeoffrey C Gurtner
Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
Nature 453:314-21. 2008..in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life...
- Notch-mediated restoration of regenerative potential to aged muscleIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
Science 302:1575-7. 2003..cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration. This was due to insufficient up-regulation of the Notch ligand Delta and, thus, diminished activation of Notch ..
- Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterraneaGeorge T Eisenhoffer
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Cell Stem Cell 3:327-39. 2008..only the ability to measure and study the in vivo population dynamics of adult stem cells during tissue homeostasis and regeneration, but also the utility of studies in planarians to broadly inform stem cell biology in adult organisms.
- Direct isolation of satellite cells for skeletal muscle regenerationDidier Montarras
CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
Science 309:2064-7. 2005Muscle satellite cells contribute to muscle regeneration. We have used a Pax3(GFP/+) mouse line to directly isolate (Pax3)(green fluorescent protein)-expressing muscle satellite cells, by flow cytometry from adult skeletal muscles, as a ..
- Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of miceKatrin Arnold
Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
Cell Stem Cell 9:317-29. 2011..Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival.
- p16INK4a induces an age-dependent decline in islet regenerative potentialJanakiraman Krishnamurthy
Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Nature 443:453-7. 2006..Here we show that p16INK4a constrains islet proliferation and regeneration in an age-dependent manner...
- Therapeutic stem and progenitor cell transplantation for organ vascularization and regenerationShahin Rafii
Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
Nat Med 9:702-12. 2003..cells to specific organs, will open up new avenues of research to accelerate organ vascularization and regeneration. In addition, identification of factors that promote differentiation of the progenitor cells will permit ..
- Human cardiac stem cellsClaudia Bearzi
Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 104:14068-73. 2007..Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin.
- Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cellsJ R Beauchamp
Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, W12 ONN United Kingdom
J Cell Biol 151:1221-34. 2000..We conclude that the expression of CD34, Myf5, and M-cadherin defines quiescent, committed precursors and speculate that the CD34(-ve), Myf5(-ve) minority may be involved in maintaining the lineage-committed majority...
- Niche regulation of muscle satellite cell self-renewal and differentiationShihuan Kuang
The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
Cell Stem Cell 2:22-31. 2008..A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases...
- Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathyArman T Askari
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Lancet 362:697-703. 2003Myocardial regeneration via stem-cell mobilisation at the time of myocardial infarction is known to occur, although the mechanism for stem-cell homing to infarcted tissue subsequently and whether this approach can be used for treatment of ..
- Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signalingRyota Uemura
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
Circ Res 98:1414-21. 2006..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
- Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationWolfram Goessling
Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Cell 136:1136-47. 2009..The relationship between PGE2 and Wnt was also conserved during regeneration of other organ systems...
- Pax7-expressing satellite cells are indispensable for adult skeletal muscle regenerationRamkumar Sambasivan
Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, Paris, F 75015, France
Development 138:3647-56. 2011..This localised loss of satellite cells was not compensated for endogenously by other cell types, but muscle regeneration was rescued after transplantation of adult Pax7(+) satellite cells alone...
- Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarctionLuciano C Amado
Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 102:11474-9. 2005....
- Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiationYoshinori Sumita
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
Int J Biochem Cell Biol 43:80-7. 2011..We propose here that cell therapy using BMDCs can rescue the functional damage of irradiated SGs by direct differentiation of donor BMDCs into salivary epithelial cells...
- A regulatory program for excretory system regeneration in planariansM Lucila Scimone
Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Development 138:4387-98. 2011..Eya and Sall, that encode transcription regulatory proteins that are required for planarian protonephridia regeneration. During regeneration, planarian stem cells are induced to form a cell population in regeneration blastemas ..
- Adenosine signaling promotes regeneration of pancreatic β cells in vivoOlov Andersson
Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology and Program in Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Cell Metab 15:885-94. 2012..Using a zebrafish model of diabetes, we screened ~7,000 small molecules to identify enhancers of β cell regeneration. The compounds we identified converge on the adenosine signaling pathway and include exogenous agonists and ..
- Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heartKonstantinos Malliaras
Cedars Sinai Heart Institute, Los Angeles, CA, USA
EMBO Mol Med 5:191-209. 2013..Thus, CDCs induce myocardial regeneration by differentially upregulating two mechanisms of endogenous cell proliferation.
- Transient regenerative potential of the neonatal mouse heartEnzo R Porrello
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 331:1078-80. 2011Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart...
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscleA Musaro
Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
Nat Genet 27:195-200. 2001..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
- Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)Birgit Assmus
Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
Circulation 106:3009-17. 2002..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
- Repairing skeletal muscle: regenerative potential of skeletal muscle stem cellsFrancesco Saverio Tedesco
Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 Via Olgettina, Milan, Italy
J Clin Invest 120:11-9. 2010..b>Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle ..
- Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytesKazu Kikuchi
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 464:601-5. 2010..Yet, there is little or no significant cardiac muscle regeneration after an injury such as acute myocardial infarction...
- Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repairCaroline Schmidt-Lucke
Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
Circulation 111:2981-7. 2005..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
- Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutHuaqi Jiang
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cell 137:1343-55. 2009..Hence, cytokine-mediated feedback enables stem cells to replace spent progeny as they are lost, thereby establishing gut homeostasis...
- Heart regenerationMichael A Laflamme
Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
Nature 473:326-35. 2011..Heart regeneration is well documented in amphibia and fish and in developing mammals...
- SMEDWI-2 is a PIWI-like protein that regulates planarian stem cellsPeter W Reddien
Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Science 310:1327-30. 2005..RNA interference (RNAi) of smedwi-2 blocks regeneration, even though neoblasts are present, irradiation-sensitive, and capable of proliferating in response to wounding;..
- Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cellsFabien Le Grand
Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
Cell Stem Cell 4:535-47. 2009..satellite stem cells expressed the Wnt receptor Fzd7 and that its candidate ligand Wnt7a was upregulated during regeneration. Wnt7a markedly stimulated the symmetric expansion of satellite stem cells but did not affect the growth or ..
- Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferationChris Jopling
Center of Regenerative Medicine in Barcelona, Spain
Nature 464:606-9. 2010..To address directly the source of newly formed cardiomyocytes during zebrafish heart regeneration, we first established a genetic strategy to trace the lineage of cardiomyocytes in the adult fish, on the basis ..
- Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiationKonstantinos E Hatzistergos
University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
Circ Res 107:913-22. 2010..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes...
- Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosisAndrew S Brack
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 317:807-10. 2007..These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age...
- Bioelectric signaling regulates head and organ size during planarian regenerationWendy Scott Beane
Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, 200 Boston Avenue, Suite 4600, Medford, MA 02155, USA
Development 140:313-22. 2013..report that membrane voltage-dependent bioelectric signaling determines both head size and organ scaling during regeneration. RNA interference of the H(+),K(+)-ATPase ion pump results in membrane hyperpolarization, which has no effect ..
- In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regenerationMeritxell Huch
Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Netherlands
Nature 494:247-50. 2013..These findings indicate that previous observations concerning Lgr5(+) stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous proliferation...
- Inflammatory processes in muscle injury and repairJames G Tidball
Department of Physiological Science, 5833 Life Science Bldg, University of California, Los Angeles, CA 90095, USA
Am J Physiol Regul Integr Comp Physiol 288:R345-53. 2005..This inflammatory response coincides with muscle repair, regeneration, and growth, which involve activation and proliferation of satellite cells, followed by their terminal ..
- The skeletal muscle satellite cell: the stem cell that came in from the coldPeter S Zammit
Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL England
J Histochem Cytochem 54:1177-91. 2006..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...
- Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult ratsWan Chun Li
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 123:2792-802. 2010..hypothesized that after partial pancreatectomy (Px) in adult rats, pancreatic-duct cells serve as a source of regeneration by undergoing a reproducible dedifferentiation and redifferentiation...
- TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regenerationDaniela Palacios
Dulbecco Telethon Institute DTI, IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00143 Roma, Italy
Cell Stem Cell 7:455-69. 2010How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown...
- A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regenerationWendy S Beane
Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155 4243, USA
Chem Biol 18:77-89. 2011..genetics approach, we demonstrate that membrane voltage controls head-versus-tail identity during planarian regeneration. Our data suggest well-characterized drugs (already approved for human use) might be exploited to control adult ..
- Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regenerationPiul Rabbani
Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
Cell 145:941-55. 2011..EpSCs and McSCs coordinately activate Wnt signaling at the onset of hair follicle regeneration within the sHG...
- The cellular basis for animal regenerationElly M Tanaka
Technical University of Dresden, DFG Center for Regenerative Therapies Dresden, c o Max Planck Institute of Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany
Dev Cell 21:172-85. 2011..advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl...
- The head-regeneration transcriptome of the planarian Schmidtea mediterraneaThomas Sandmann
Division Signaling and Functional Genomics, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Genome Biol 12:R76. 2011..Despite the enormous potential of these animals for medical research and regenerative medicine, the mechanisms of regeneration and the molecules involved remain largely unknown.
- Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tipYuval Rinkevich
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305 5323, USA
Nature 476:409-13. 2011The regrowth of amputated limbs and the distal tips of digits represent models of tissue regeneration in amphibians, fish and mice...
- microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7Jian Fu Chen
McAllister Heart Institute, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 190:867-79. 2010Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation...
- Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regenerationKathleen Kelly Tanaka
MCD Biology, University of Colorado, Boulder, CO 80309, USA
Cell Stem Cell 4:217-25. 2009..cells, located between the basal lamina and plasma membrane of myofibers, are required for skeletal muscle regeneration. The capacity of satellite cells as well as other cell lineages including mesoangioblasts, mesenchymal stem ..
- Cells keep a memory of their tissue origin during axolotl limb regenerationMartin Kragl
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
Nature 460:60-5. 2009During limb regeneration adult tissue is converted into a zone of undifferentiated progenitors called the blastema that reforms the diverse tissues of the limb...
- Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regenerationHideki Iwaguro
Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
Circulation 105:732-8. 2002..In the current study, we investigated the hypothesis that gene transfer can be used to achieve phenotypic modulation of EPCs...
- Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stageFrederic Relaix
UPMC Paris 06, UMR S 787, F 75013, Paris, France
Development 139:2845-56. 2012..accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established...
- Control of pancreatic β cell regeneration by glucose metabolismShay Porat
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
Cell Metab 13:440-9. 2011..Physiologic β cell regeneration under stressed conditions relies on accelerated proliferation of surviving β cells, but the factors that ..
- Hedgehog signalling in prostate regeneration, neoplasia and metastasisSunil S Karhadkar
Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 431:707-12. 2004..of the Hedgehog (Hh) signalling pathway, which has essential roles in developmental patterning, is required for regeneration of prostate epithelium, and that continuous pathway activation transforms prostate progenitor cells and renders ..
- PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCsArnold I Caplan
Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, Ohio 44106 7080, USA
J Orthop Res 29:1795-803. 2011With the identification of mesenchymal stem cells (MSCs) as pericytes, the details of bone formation, regeneration, and repair take on new meaning...
- Restoration of anterior regeneration in a planarian with limited regenerative abilityJames M Sikes
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Nature 500:77-80. 2013..regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found...
- The zebrafish as a model for complex tissue regenerationMatthew Gemberling
Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Trends Genet 29:611-20. 2013For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species...
- The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epitheliumEmma L Rawlins
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell Stem Cell 4:525-34. 2009..Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells...
- Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cellsK A Jackson
Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
J Clin Invest 107:1395-402. 2001..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction...
- Impact of ageing on muscle cell regenerationSilvia Carosio
Institute Pasteur Cenci Bolognetti, Department of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A Scarpa, 14, Rome 00161, Italy
Ageing Res Rev 10:35-42. 2011Skeletal muscle regeneration is a coordinate process in which several factors are sequentially activated to maintain and preserve muscle structure and function...
- ADAM17: a molecular switch to control inflammation and tissue regenerationJürgen Scheller
Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
Trends Immunol 32:380-7. 2011..Tissue-specific deletion, or hypomorphic knock-in, of Adam17 demonstrates an in vivo role for ADAM17 in controlling inflammation and tissue regeneration. The potential of ADAM17 as therapeutic target is also discussed.
- Metchnikoff's policemen: macrophages in development, homeostasis and regenerationJames A Stefater
Visual Systems Group, Divisions of Pediatric Ophthalmology and Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Trends Mol Med 17:743-52. 2011..We also detail how modern genetic tools have facilitated new insights into these mysterious cells...
- Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trialRaj R Makkar
Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
Lancet 379:895-904. 2012..We aimed to assess safety of such an approach in patients with left ventricular dysfunction after myocardial infarction...
- microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in miceNing Liu
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
J Clin Invest 122:2054-65. 2012..microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined...
- Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemiaSimona Greco
Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Milan, Italy
FASEB J 23:3335-46. 2009..to identify micro-RNAs (miRNAs) involved in the pathological pathways activated in skeletal muscle damage and regeneration by both dystrophin absence and acute ischemia...
- Regeneration of glomerular podocytes by human renal progenitorsElisa Ronconi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
J Am Soc Nephrol 20:322-32. 2009..in a precise sequence within Bowman's capsule and exhibit heterogeneous potential for differentiation and regeneration. Cells localized to the urinary pole that expressed CD133 and CD24, but not podocyte markers (CD133+CD24+PDX- ..
- Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal developmentKathryn J Mitchell
Myology Group, UMR S 787 INSERM, Universite Pierre et Marie Curie Paris VI, Paris, 75634, France
Nat Cell Biol 12:257-66. 2010..PW1(+)/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs...
- Evidence for human lung stem cellsJan Kajstura
Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 364:1795-806. 2011..Although progenitor cells have been described in distinct anatomical regions of the lung, description of resident stem cells has remained elusive...
- Adult satellite cells and embryonic muscle progenitors have distinct genetic requirementsChristoph Lepper
Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
Nature 460:627-31. 2009..of inducible Cre/loxP lineage tracing and conditional gene inactivation to the tibialis anterior muscle regeneration paradigm, that, unexpectedly, when Pax7 is inactivated in adult mice, mutant satellite cells are not ..
- Distinct Wnt signaling pathways have opposing roles in appendage regenerationCristi L Stoick-Cooper
Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Development 134:479-89. 2007..This process, termed epimorphic regeneration, involves progenitor cells created through the reprogramming of differentiated cells or through the activation ..
- Identification of telocytes in skeletal muscle interstitium: implication for muscle regenerationL M Popescu
Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
J Cell Mol Med 15:1379-92. 2011..is crucial for regulation of blood flow, passage of substances from capillaries to myocytes and muscle regeneration. We show here, probably, for the first time, the presence of telocytes (TCs), a peculiar type of interstitial (..
- Wound repair and regenerationJ M Reinke
Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
Eur Surg Res 49:35-43. 2012..As healing and regeneration processes take place in all parts of the human body, this review focuses on the healing processes of the skin ..
- Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regenerationNick R Love
Faculty of Life Sciences, University of Manchester, UK
Nat Cell Biol 15:222-8. 2013Understanding the molecular mechanisms that promote successful tissue regeneration is critical for continued advancements in regenerative medicine...
- The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletionJinhu Wang
Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Development 138:3421-30. 2011Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size...
- Satellite cells, the engines of muscle repairYu Xin Wang
Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute Ottawa, 501 Smyth Road Ottawa, Ontario K1H 8L6, Canada
Nat Rev Mol Cell Biol 13:127-33. 2011..are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle...
- Human fetal membranes: a source of stem cells for tissue regeneration and repair?S Ilancheran
Monash Institute of Medical Research, Department of Medicine, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
Placenta 30:2-10. 2009..Amniotic epithelial cells also produce numerous substances that could augment tissue regeneration and repair...
- Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regenerationValentina Guasconi
Istituto Dulbecco Telethon at Istituto Di Ricovero e Cura a Carattere Scientifico, Santa Lucia Fondazione and European Brain Research Institute, 64 Via del Fosso di Fiorano, Rome, Italy
Trends Cell Biol 19:286-94. 2009Muscle regeneration provides a paradigm by which to study how extrinsic signals coordinate gene expression in somatic stem cells (satellite cells) by directing the genome distribution of chromatin-modifying complexes...
- Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterraneaYi Chien Lu
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
RNA 15:1483-91. 2009..Together, these results increase the known repertoire of S. mediterranea miRNAs and identify numerous regulated miRNAs that may play important roles in regeneration, homeostasis, neoblast function, and reproduction.
- Regulatory interactions between muscle and the immune system during muscle regenerationJames G Tidball
Molecular, Cellular and Integrative Physiology Program, Department of Integrative Biology and Physiology, University of California Los Angeles, CA 90095 1606, USA
Am J Physiol Regul Integr Comp Physiol 298:R1173-87. 2010..Recent discoveries reveal complex interactions between skeletal muscle and the immune system that regulate muscle regeneration. In this review, we evaluate evidence that indicates that the response of myeloid cells to muscle injury ..
- Heart regeneration in zebrafishKenneth D Poss
Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
Science 298:2188-90. 2002Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection...
- Wnt-dependent de novo hair follicle regeneration in adult mouse skin after woundingMayumi Ito
Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nature 447:316-20. 2007..These findings suggest treatments for wounds, hair loss and other degenerative skin disorders...
- JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gutBenoit Biteau
Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA
Cell Stem Cell 3:442-55. 2008..Here we show that cytoprotective Jun N-terminal kinase (JNK) signaling influences regeneration in the Drosophila gut by directing proliferation of intestinal stem cells (ISCs)...
- Limbal stem-cell therapy and long-term corneal regenerationPaolo Rama
San Raffaele Scientific Institute, Ophthalmology Unit, Milan, Italy
N Engl J Med 363:147-55. 2010..We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction associated with limbal stem-cell deficiency, a highly disabling ocular disease...
- MET signalling: principles and functions in development, organ regeneration and cancerLivio Trusolino
Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo, Torino, Italy
Nat Rev Mol Cell Biol 11:834-48. 2010..Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression...
- Dynamic reciprocity in the wound microenvironmentGregory S Schultz
Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
Wound Repair Regen 19:134-48. 2011..The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered...
- Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regenerationJose E Heredia
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
Cell 153:376-88. 2013..Here, we demonstrate that type 2 innate immunity is required for regeneration of skeletal muscle after injury...
- The molecular regulation of myogenesisL A Sabourin
Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
Clin Genet 57:16-25. 2000..This has put forward the hypothesis that these factors also play specific biological roles following muscle injury and repair...
- Functional Restoration of the Optic Nerve After Disease or DamageDong Feng Chen; Fiscal Year: 2010..of neuroanatomy, cellular biology and mouse behavior tests to probe for mechanisms regulating optic nerve regeneration and restoring vision after injury or diseases...
- James D Bryers; Fiscal Year: 2016..Guided tissue regeneration (GTR) techniques are increasingly being used for the treatment of periodontal defects, or in conjunction with ..
- Ligand Directed Transdermal siRNA Delivery to Improve Wound HealingDavid M Evans; Fiscal Year: 2012..biology have greatly expanded our understanding of the biologic processes involved in wound repair and tissue regeneration and have led to improvements in wound care. Cutaneous wound healing differs between fetal and adult skin...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2013..We have also found that sphingosine kinase and S1P lyase are dynamically upregulated during murine muscle regeneration, leading to a transient peak in S1P levels in regenerating muscle...
- Bayar Thimmapaya; Fiscal Year: 2016..biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to regain partially lost metabolic functions...
- Retinoid Metabolism and Alcohol Induced DiseaseWilliam S Blaner; Fiscal Year: 2010..How does the absence of hepatic retinoid stores influence alcohol-induced liver disease development and liver regeneration? These investigations will involve the use of Lrat-/- mice to explore the role that hepatic retinoid stores and ..
- Rac GTPase signaling during embryonic salivary gland branching morphogenesisSharon Sequeira; Fiscal Year: 2012..More long term solutions include tissue replacement and regeneration therapies, however, the significant challenge of maintaining and stimulating epithelial cell organization and ..
- Transgenesis and XenotransplantationJorge A Piedrahita; Fiscal Year: 2013..This aim will allow us to determine the strengths and weaknesses of this xenotransplant organ regeneration approach so it can be used in the future to develop tissue and organs of greater complexity such as lung and ..
- Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental DefectsChristopher H Evans; Fiscal Year: 2010..Challenge Area (11): Regenerative Medicine, and specific Challenge Topic 11-AR-101 Musculoskeletal and Skin Regeneration Every year, over a million Americans are hospitalized for bone fractures at a cumulative cost of over $100 ..
- Remote-control mouse-implantable micropumps for establishment of regenerative capJUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010..The concentrations of these molecular regulators exhibit temporal variation during regeneration, and this time-dependence is important for successful MuSC activation and preventing fibrosis (Brack, 2007)...
- Integrated signaling of eicosanoids in HSC formation and regenerationTrista E North; Fiscal Year: 2013..PGE2 and CBs, act individually and in concert to exert specific effects on HSCs during embryogenesis and regeneration. This hypothesis has been derived from our own screening results and subsequent preliminary data as well as ..
- Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule CellDIANA LYNNE GOLDEN; Fiscal Year: 2012..Tubular regeneration restores normal tubular architecture and renal function following kidney injury...
- Molecular Mechanisms of Chemoprevention: NRF2 SignalingThomas W Kensler; Fiscal Year: 2013..Third, we will capitalize on our novel observation that Nrf2 signaling influences tissue regeneration and repair by examining the post initiation effects of triterpenoids during aflatoxin-induced ..
- Mark S Nanes; Fiscal Year: 2014..However, these medications do not enhance healing and regeneration of bone for a return to normal...
- SATDARSHAN SINGH MONGA; Fiscal Year: 2016..identifies areas such as understanding cellular and molecular processes of normal liver cell functioning;liver regeneration and development;and hepatic fibrosis;to make an overall impact on liver health...
- Histone Chaperones in AngiogenesisSoumen Paul; Fiscal Year: 2012..Information gleaned from these studies will contribute to our understanding of the molecular mechanisms of angiogenesis and hopefully will lead to novel therapeutic modalities for vascular regeneration and anti-angiogenesis therapy.
- Optical Molecular Tomography for Regenerative MedicineGe Wang; Fiscal Year: 2013..in the carotid arteries of living sheep, and will be imaged in 500[unreadable]m resolution to follow the tissue regeneration and function...
- GARY ANDREW WEISMAN; Fiscal Year: 2016..Progress has been made in strategies for the regeneration of a variety of tissues including skin, corneal epithelium, cartilage, bone and bladder...
- John M Sullivan; Fiscal Year: 2016..and RetDi in RPE cells reflects the normal daily accumulation of ATR from the visual cycle, with bleaching and regeneration of rod and cone opsins, integrated over many years...
- Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in HydrogelSihong Wang; Fiscal Year: 2010..elevation is common during inflammation after tissue injury and may have an important role in tissue regeneration. However, the mechanisms for temperature-induced bone cell differentiation as well as overexpression of HSPs ..
- Use of umbilical cord as a unique stem cell source for tissue regenerationXiao Dong Chen; Fiscal Year: 2013..human UCB contains a large number of embryonic-like stem cells that have the potential to be used for tissue regeneration in general and myocardial reconstruction in particular...
- Somatic Stem Cells in Engineered Human SkinSteven Boyce; Fiscal Year: 2009..Only by making this change in approach will the ultimate goal of skin regeneration replace the dogma of wound repair which leads to scar and disability...
- The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and ObesityYanjun Liu; Fiscal Year: 2013..which is utilized by 112-HSD1, thus constituting a connection of H6PDH and 112-HSD1 in regulation of tissue GC regeneration. In support of this, H6PDH knockout mice are unable to regenerate tissue GCs and impaired 112- HSD1 activity...
- Link of beta cell proliferation and type 2 diabetes to epigenetic regulationXianxin Hua; Fiscal Year: 2013..Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D)...
- TRINITY JUDE BIVALACQUA; Fiscal Year: 2015..of selective RhoA and ROCK inhibitors effects in the context of neuroregulated erectile function and axonal regeneration are proposed after cavernous nerve injury...
- Paula K Shireman; Fiscal Year: 2015DESCRIPTION (provided by applicant): Stem cells and tissue regeneration have great therapeutic promise for treatment of a wide variety of medical conditions...
- Mechanisms of Astrocyte DevelopmentTeri L Belecky Adams; Fiscal Year: 2010..component of the nervous system, known as reactive astrocytes, which form permanent barriers to axonal regeneration. Developing optic nerve astrocytes (astrocyte precursors) play a number of roles that are unique to the eye...
- Implantation of physiologically functional bioengineered innervated IAS constructKhalil N Bitar; Fiscal Year: 2010DESCRIPTION (provided by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
- Optimization of EphA4 antagonists for CNS disordersELENA B contact PASQUALE; Fiscal Year: 2010..In the injured nervous system, EphA4 inhibits nerve regeneration and functional recovery by promoting glial scar formation and inhibiting sprouting of injured axons...
- Signal Transduction Mechanism of Osteoclast DifferentiationNandini Ghosh-Choudhury; Fiscal Year: 2013..The bone morphogenetic proteins (BMPs) are used as therapeutic measures for promoting bone regeneration. Recent reports suggest that BMPs act on osteoclasts indirectly through osteoblasts or stromal cells...
- Stem Cell Based Therapy For Radiation Induced Gastrointestinal SyndromeChandan Guha; Fiscal Year: 2010..These stromal cells provide the niche and could supply critical growth factor/signals for ISC regeneration. For example, upon intestinal mucosal disruption, resident macrophages in the intestinal submucosal layers are ..
- Therapeutic use of small-molecule HGF-mimetic for emphysemaBERT J W M OEHLEN; Fiscal Year: 2010..suggest that hepatocyte growth factor (HGF), a pleiotropic cytokine, has multiple activities that lead to lung regeneration. Such activities include promotion of elastin synthesis, suppression of apoptosis, suppression of inflammation, ..
- Microfluidic-microtiter interface for rapid large-scale screenings of C. elegansAdela Ben Yakar; Fiscal Year: 2010DESCRIPTION (provided by applicant): After injury, unlike the axons of the central nervous system where the regeneration process is poor or absent, axons of the peripheral nervous system are able to regenerate, though inefficiently...
- Eph/ephrin signaling in craniofacial development and diseaseJEFFREY OHMANN BUSH; Fiscal Year: 2010..Biology includes fourteen full-time faculty that study various questions centered on the development, regeneration, and patterning of organs...
- Suzette Laing; Fiscal Year: 2016..the use of vascular gene therapy in a clinical setting and uncovering alternative approaches to vascular regeneration and remodeling...
- Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/ProliferationWilliam L Holland; Fiscal Year: 2010..The PANIC ATTAC mouse allows the unique opportunity to evaluate beta cell regeneration following the cell specific and titratable induction of apoptosis.
- INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATIONJOSEPH VINCENT BONVENTRE; Fiscal Year: 2010..addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
- Pbx Homeodomain Proteins in Skeletal Muscle DifferentiationLISA A MAVES; Fiscal Year: 2011..muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular dystrophies and muscle tumors...
- Marcel R m van den Brink; Fiscal Year: 2016DESCRIPTION (provided by applicant): Endogenous regeneration of the thymus is a crucial function that allows for renewal of immune competence following infection, shock, cytoreductive chemo- or radiation therapy and other causes of ..
- Investigating the role of interleukin-22 in thymus functionJarrod Dudakov; Fiscal Year: 2013DESCRIPTION (provided by applicant): Endogenous regeneration of the thymus is a crucial function that allows for renewal of immune competence following infection, shock or common cancer therapies such as cytoreductive chemo- or radiation ..
- Lina Lu; Fiscal Year: 2014..HSC are the main retinoid storing cells in the body and are known to be actively involved in liver repair and regeneration by synthesizing extracellular matrix protein and secretion of cytokines and growth factors...
- Paul S Frenette; Fiscal Year: 2016..Our preliminary studies suggest that a lesion to the SNS impairs the regeneration of the niche and recovery of hematopoiesis following a stressful challenge such as stem cell transplantation or ..
- Alan M Hanash; Fiscal Year: 2016..will not only lead to better understanding of immunobiology, intestinal stem cell physiology, epithelial regeneration, and GVHD pathophysiology, but will also lead to the development novel strategies to reduce epithelial damage ..
- Genomic approaches to inner ear hair cell regenerationMichael Lovett; Fiscal Year: 2010..order to achieve this goal, we first need to identify the molecular genetic pathways that will lead to sensory regeneration. Until now our insights into these processes were limited by genomic tools that were either not cost effective ..
- Astrocyte Development and Reactive GliosisTeri L Belecky-Adams; Fiscal Year: 2012..eye, these cells become reactive, whereupon they begin expressing molecules that are unfavorable to the regeneration of the optic nerve...
- Eph/ephrin signaling in craniofacial development and diseaseJEFFREY OHMANN BUSH; Fiscal Year: 2013..Biology includes fourteen full-time faculty that study various questions centered on the development, regeneration, and patterning of organs...
- Mabel L Rice; Fiscal Year: 2016..as a predictor of later cognitive and language development, clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth ..
- Novel Small Molecules For Acute Liver FailurePrakash Narayan; Fiscal Year: 2009..studies that identify and develop new therapeutic strategies that attenuate hepatocyte death, promote hepatic regeneration and improve outcome...
- Surgical Wound Repair: Role of A Neuroendothelial AxisNICOLE SIMONE GIBRAN; Fiscal Year: 2010..cell response to injury and 2) microvascular endothelial cells secrete neurotrophins that regulate nerve fiber regeneration. We will test our hypothesis by addressing the following aims: 1) To determine effects of nervederived ..
- Guodong Cao; Fiscal Year: 2016..central hypothesis to be tested is that NAMPT protects against WMI via enhancing oligodendrocytic protection/ regeneration and microglia-mediated myelin phagocytosis...
- Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.Xianxin Hua; Fiscal Year: 2010..Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D)...
- FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENTGary W Conrad; Fiscal Year: 2012..Resulting regeneration and wound healing reactions of surrounding surviving corneal nerves and keratocytes involve cellular migrations ..
- Mitoenergetic Failure in Brain AgingGregory J Brewer; Fiscal Year: 2013..have recent evidence that mitochondria from old rat neurons in culture promote normal neuron survival, normal regeneration, normal glucose uptake and normal respiration, but do so with decrepit mitochondria which fail to upregulate ..
- Skin Regeneration with Stem Cells and ScaffoldsSUSAN RENEE OPALENIK; Fiscal Year: 2013DESCRIPTION (provided by applicant): In damaged skin, regeneration is not the same as filling and resurfacing...
- Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver RegenerationKRISTEN ANDREA MITCHELL; Fiscal Year: 2010DESCRIPTION (provided by the applicant): Incomplete liver regeneration is an obstacle to recovery from liver disease and for patients who receive grafts through living-donor liver transplantation...
- RUBIE ANN RAKIAN; Fiscal Year: 2016..vitro;2) Demonstrate the capacity of predifferentiated MSCs maintained on AlloDerm for oral mucosa epithelium regeneration in vivo using an athymic nude mouse model...
- Mesonephric Model of Podocyte Injury and RegenerationWeibin Zhou; Fiscal Year: 2012..model system that I have developed for the study of molecular mechanisms of nephrotic syndrome and podocyte regeneration. This will aid the transition of my research career toward an independent investigator position...
- Mechanism of p63-Dependent Tumor SuppressionXinbin Chen; Fiscal Year: 2012..expressed primarily in epithelial cells and appears to be necessary for the differentiation, maintenance, and regeneration of epithelial stem cells. In addition, mutant mice have developmental abnormalities...
- Trophokine for regenerative medicineJianmin Fang; Fiscal Year: 2010..and triggers signal transduction that protects cells against apoptosis and enhances cell growth for tissue regeneration. The profound effects of HGF to prevent cell death and to promote tissue regeneration make HGF an interesting ..
- Leonard P Rybak; Fiscal Year: 2016..It is induced in kidney by cisplatin. This molecule may enhance repair and regeneration of proximal tubule cells...
- IKKbeta:Bi-Functional Regulator of Hepatocyte ProliferationHyam L Leffert; Fiscal Year: 2010..by applicant): The long-term goals of this proposal are directed towards understanding mechanisms of liver regeneration and hepatocarcinogenesis...
- Bruce R Blazar; Fiscal Year: 2016..Hypothesis: LN stroma regeneration will increase immune function...
- Cardiac Regeneration through Growth Factor Eluting Microrod ScaffoldsPaul H Goldspink; Fiscal Year: 2013..proposed in this application combines bioengineering and cell biology-based techniques to directly target the regeneration of heart muscle, which is an important clinical problem not well addressed by current therapies...
- Laser Spinning Disc Confocal System for live-cell and live-organism microscopyMartha C Soto; Fiscal Year: 2012..understanding of such essential cellular phenomena as protein trafficking, polarization of the cytoskeleton and regeneration in neurons...
- Biomimetic scaffolds for targeted peripheral nerve regenerationDAVID SHREIBER; Fiscal Year: 2009..The broad, long-term objective of this research is to develop an implantable construct for peripheral nerve regeneration following nerve trauma...
- microRNA Uncoupling of Protein and Transcript Expression in Liver RegenerationCLIFFORD JOHN STEER; Fiscal Year: 2010..Our hypothesis is that microRNAs are required for liver regeneration and primarily responsible for the observed uncoupling of protein and transcript expression after PH...
- METABOLIC HOMEOSTASIS IN LIVER REGENERATIONLINDA GREENBAUM; Fiscal Year: 1999Liver regeneration following partial hepatectomy is one of the few models in which it is possible to study cellular proliferation in the intact animal...
- Intravenous Protein Therapy for Treatment of Congenital Muscular DystrophyBradley L Hodges; Fiscal Year: 2010..A substantial delay in muscle regeneration occurs when skeletal muscle degeneration of dyW is provoked by notexin, indicating that an additional ..
- STEROID HORMONES AND NEURONAL REGENERATIONKathryn Jones; Fiscal Year: 2001DESCRIPTION: The investigator has identified a role for testosterone propionate (TP) in enhancing neuronal regeneration of the crushed facial nerve in adult hamsters...
- MOLECULAR CONTROL OF LIVER REGENERATIONRebecca Taub; Fiscal Year: 2000DESCRIPTION: Liver regeneration following partial hepatectomy provides one of the few examples of a physiologic growth response occurring in the intact animal...
- Molecular Heparan Sulfate Delivery in Guided Tissue RegenerationArthur A Decarlo; Fiscal Year: 2010DESCRIPTION (provided by applicant): Barrier membranes are an important adjunct to regeneration therapy aimed at restoring the form and function of the mouth...
- REGENERATION IN THE SPINAL CORD-ROLE OF NEUROFILAMENTMICHAEL SELZER; Fiscal Year: 2003..from applicant's abstract): This revised application makes use of the sea lamprey as a model system for axon regeneration in the CNS...
- GENE THERAPY FOR SPINAL CORD REGENERATIONGeorge Smith; Fiscal Year: 2006..or the lack of a good growth supportive substrate, produce an environment that is refractory to axonal regeneration. This application is designed to examine the hypothesis that a selective expression of growth-supportive and ..
- Gene profiling of nervous system regeneration using a novel model organismJose E Garcia Arraras; Fiscal Year: 2010Gene profiling of nervous system regeneration using a novel model organism Post-traumatic regeneration of neurons and fibers in the mammalian spinal cord has not been plausible, even though extensive studies have been made to understand ..