Genomes and Genes
Summary: Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
Publications436 found, 100 shown here
- Multilineage potential of adult human mesenchymal stem cellsM F Pittenger
Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
Science 284:143-7. 1999..These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential...
- Multilineage cells from human adipose tissue: implications for cell-based therapiesP A Zuk
Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
Tissue Eng 7:211-28. 2001..In conclusion, the data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs...
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesitySatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Nat Med 15:914-20. 2009..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation...
- Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansSaverio Cinti
Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
J Lipid Res 46:2347-55. 2005..We demonstrate that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual "free" adipocyte lipid droplet and ..
- Adipose tissue, adipokines, and inflammationGiamila Fantuzzi
Department of Human Nutrition, University of Illinois at Chicago, USA
J Allergy Clin Immunol 115:911-9; quiz 920. 2005..Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation...
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceHaiyan Xu
Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
J Clin Invest 112:1821-30. 2003..We propose that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue...
- Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentRowena McBeath
The Cellular and Molecular Medicine Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 6:483-95. 2004..hMSCs allowed to adhere, flatten, and spread underwent osteogenesis, while unspread, round cells became adipocytes. Cell shape regulated the switch in lineage commitment by modulating endogenous RhoA activity...
- Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspectiveSam Virtue
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Box 289, Level 4, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Biochim Biophys Acta 1801:338-49. 2010..Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments...
- Inflammation and insulin resistanceSteven E Shoelson
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:1793-801. 2006....
- Adaptive thermogenesis in adipocytes: is beige the new brown?Jun Wu
Dana Farber Cancer Institute, Boston, MA 02115, USA
Genes Dev 27:234-50. 2013..A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases...
- Adipokines: inflammation and the pleiotropic role of white adipose tissuePaul Trayhurn
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
Br J Nutr 92:347-55. 2004..the term 'adipokine' be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released ..
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growthKristin M Nieman
Department of Obstetrics and Gynecology Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL, USA
Nat Med 17:1498-503. 2011..such as ovarian cancer, have a clear predilection for metastasis to the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why tumor cells preferentially home to and proliferate in the omentum, yet omental ..
- Inhibition of adipogenesis by Wnt signalingS E Ross
Department of Physiology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
Science 289:950-3. 2000..preadipocytes is prevented by overexpression of Axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, ..
- Beige adipocytes are a distinct type of thermogenic fat cell in mouse and humanJun Wu
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
Cell 150:366-76. 2012..Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:
- Transcriptional control of brown fat determination by PRDM16Patrick Seale
Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
Cell Metab 6:38-54. 2007..PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate...
- CCAAT/enhancer-binding proteins: structure, function and regulationDipak P Ramji
Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
Biochem J 365:561-75. 2002..and differentiation, metabolism, inflammation and numerous other responses, particularly in hepatocytes, adipocytes and haematopoietic cells...
- Adipose tissue remodeling and obesityKai Sun
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
J Clin Invest 121:2094-101. 2011..As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that ..
- The many faces of PPARgammaMichael Lehrke
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell 123:993-9. 2005....
- Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysisDawn L Brasaemle
Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
J Lipid Res 48:2547-59. 2007..In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich droplets of many other cells ..
- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesAdilson Guilherme
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Rev Mol Cell Biol 9:367-77. 2008..reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty ..
- Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liverE D Abel
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 409:729-33. 2001..type 2 diabetes is insulin resistance, characterized by decreased glucose transport and metabolism in muscle and adipocytes. The glucose transporter GLUT4 mediates insulin-stimulated glucose uptake in adipocytes and muscle by rapidly ..
- AdipoQ is a novel adipose-specific gene dysregulated in obesityE Hu
Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 271:10697-703. 1996..Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue...
- Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese miceShiho Fujisaka
First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Science for Research, Tokyo, Japan
Diabetes 58:2574-82. 2009..To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity...
- Adipose tissue dysfunction in obesity, diabetes, and vascular diseasesGideon R Hajer
Department of Vascular Medicine, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Eur Heart J 29:2959-71. 2008..First, normal physiology of adipocytes and adipose tissue will be described.
- PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinN Maeda
Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
Diabetes 50:2094-9. 2001..In cultured 3T3-L1 adipocytes, TZD derivatives enhanced the mRNA expression and secretion of adiponectin in a dose- and time-dependent manner...
- PPARs and the complex journey to obesityRonald M Evans
Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nat Med 10:355-61. 2004..With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging...
- T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesityHuaizhu Wu
Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
Circulation 115:1029-38. 2007..T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity...
- MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesityHuangming Xie
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Diabetes 58:1050-7. 2009..We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity...
- Increased oxidative stress in obesity and its impact on metabolic syndromeShigetada Furukawa
Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Clin Invest 114:1752-61. 2004..In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress ..
- The adipocyte-secreted protein Acrp30 enhances hepatic insulin actionA H Berg
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Nat Med 7:947-53. 2001..We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism...
- Surface protein characterization of human adipose tissue-derived stromal cellsS Gronthos
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
J Cell Physiol 189:54-63. 2001..The similarities between the phenotypes of human adipose tissue-derived and human bone marrow-derived stromal cells could have broad implications for human tissue engineering...
- Developmental origin of fat: tracking obesity to its sourceStephane Gesta
Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Cell 131:242-56. 2007..In this Review, we consider how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explore how these factors may play a role in the growing epidemic of obesity...
- Adipose-derived stem cells: isolation, expansion and differentiationBruce A Bunnell
Division of Gene Therapy, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
Methods 45:115-20. 2008..While this article has focused on the isolation of ASCs from human adipose tissue, the procedure can be applied to adipose tissues from other species with minimal modifications...
- TLR4 links innate immunity and fatty acid-induced insulin resistanceHang Shi
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:3015-25. 2006..nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue ..
- Forming functional fat: a growing understanding of adipocyte differentiationAna G Cristancho
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Mol Cell Biol 12:722-34. 2011Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis...
- Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesisRonni Nielsen
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
Genes Dev 22:2953-67. 2008..We identify >5000 high-confidence shared PPARgamma:RXR-binding sites in adipocytes and show that during early stages of differentiation, many of these are preoccupied by non-PPARgamma RXR-..
- Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytesYu Chen
Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
J Cell Biol 198:545-60. 2012..Thus, multiple Rab proteins regulate the trafficking of GLUT4, with Rab10 coordinating with myosin-Va to mediate the final steps of insulin-stimulated GSV translocation to the PM...
- Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acidsHongfei Ge
Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
Endocrinology 149:4519-26. 2008..GPR43 is also expressed in a number of other tissues including adipocytes; however, the functional consequences of GPR43 activation in these other tissues are not clear...
- Marrow stromal cells as stem cells for nonhematopoietic tissuesD J Prockop
Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
Science 276:71-4. 1997..roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts...
- Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosisL Makowski
Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Med 7:699-705. 2001..Apoe-/- mice with Ap2+/+ adipocytes and Ap2-/- macrophages generated by bone-marrow transplantation showed a comparable reduction in atherosclerotic ..
- A transgenic model of visceral obesity and the metabolic syndromeH Masuzaki
Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
Science 294:2166-70. 2001..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
- Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytesDawn L Brasaemle
Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
J Biol Chem 279:46835-42. 2004b>Adipocytes hold the body's major energy reserve as triacylglycerols packaged in large lipid droplets...
- Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivityKihwa Kang
Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
Cell Metab 7:485-95. 2008..However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including IL-13 and to a lesser extent IL-4, which induce macrophage PPARdelta/..
- Monocyte chemoattractant protein 1 in obesity and insulin resistancePeter Sartipy
Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, VB 3, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:7265-70. 2003..insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in IR obese mice (ob/ob). Thus, MCP-1 resembles other previously described genes (e.g...
- A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alphaTakayoshi Suganami
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
Arterioscler Thromb Vasc Biol 25:2062-8. 2005..Here we developed an in vitro coculture system composed of adipocytes and macrophages and examined the molecular mechanism whereby these cells communicate.
- Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophagesTakayoshi Suganami
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
Arterioscler Thromb Vasc Biol 27:84-91. 2007..Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (..
- Metabolic dysregulation and adipose tissue fibrosis: role of collagen VITayeba Khan
Department of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Cell Biol 29:1575-91. 2009b>Adipocytes are embedded in a unique extracellular matrix whose main function is to provide mechanical support, in addition to participating in a variety of signaling events...
- Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinedionesPaul A Dutchak
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Cell 148:556-67. 2012..Adding back FGF21 prevents sumoylation and restores PPARγ activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPARγ...
- C/EBPalpha induces adipogenesis through PPARgamma: a unified pathwayEvan D Rosen
Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Genes Dev 16:22-6. 2002..These results indicate that C/EBPalpha and PPARgamma participate in a single pathway of fat cell development with PPARgamma being the proximal effector of adipogenesis...
- Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytesSéverine Kirchner
Department of Developmental and Cell Biology, 2011 Biological Sciences 3, University of California, Irvine, California 92697 2300, USA
Mol Endocrinol 24:526-39. 2010..Hence, TBT alters the stem cell compartment by sensitizing multipotent stromal stem cells to differentiate into adipocytes, an effect that could likely increase adipose mass over time.
- Mesenchymal stem cells can be differentiated into endothelial cells in vitroJoachim Oswald
Institute of Polymer Research Dresden and The Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
Stem Cells 22:377-84. 2004..cells (MSCs) have the potential to differentiate into mesenchymal tissues like osteocytes, chondrocytes, and adipocytes in vivo and in vitro...
- New developments in adipogenesisMartina I Lefterova
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Trends Endocrinol Metab 20:107-14. 2009The obesity epidemic has focused attention on adipose tissue and the development of fat cells (i.e. adipocytes), which is known as adipogenesis...
- The hormone resistin links obesity to diabetesC M Steppan
Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Nature 409:307-12. 2001..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
- Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cellsKarin Stenderup
University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
Bone 33:919-26. 2003..In adipogenic medium similar numbers of adipocytes formed in cultures of young and old donors...
- Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient miceNicholas M Morton
Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
Diabetes 53:931-8. 2004..Isolated 11 beta-HSD-1(-/-) adipocytes exhibited higher basal and insulin-stimulated glucose uptake...
- Adipocyte differentiation from the inside outEvan D Rosen
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nat Rev Mol Cell Biol 7:885-96. 2006....
- Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipaseGuenter Haemmerle
Institute of Molecular Biosciences, University of Graz, Austria
Science 312:734-7. 2006..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
- Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolismKerry B Goralski
Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
J Biol Chem 282:28175-88. 2007..Here we show an unexpected, high level expression of chemerin and its cognate receptor CMKLR1 in mouse and human adipocytes. Cultured 3T3-L1 adipocytes secrete chemerin protein, which triggers CMKLR1 signaling in adipocytes and other ..
- Adipokine dysregulation, adipose tissue inflammation and metabolic syndromeE Maury
Endocrinology and Metabolism Unit, University of Louvain, Faculty of Medicine, 1200 Brussels, Belgium
Mol Cell Endocrinol 314:1-16. 2010..Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome...
- Comparative epigenomic analysis of murine and human adipogenesisTarjei S Mikkelsen
Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
Cell 143:156-69. 2010..We also utilize the close relationship between open chromatin marks and transcription factor motifs to identify and validate PLZF and SRF as regulators of adipogenesis...
- The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistanceGijs H Goossens
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Physiol Behav 94:206-18. 2008..Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Adipocytes are of importance in buffering the daily influx of dietary fat and exert autocrine, paracrine and/or endocrine ..
- Increased adipose tissue in male and female estrogen receptor-alpha knockout miceP A Heine
Departments of Veterinary Biosciences and Kinesiology, University of Illinois, Urbana, IL 61802, USA
Proc Natl Acad Sci U S A 97:12729-34. 2000..These results are evidence that estrogen/ERalpha signaling is critical in female and male WAT; obesity in alphaERKO males involves a mechanism of reduced energy expenditure rather than increased energy intake...
- Adipose development: from stem cell to adipocyteTamara C Otto
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Crit Rev Biochem Mol Biol 40:229-42. 2005Cell culture models have been developed to study commitment and subsequent differentiation of preadipocytes into adipocytes. Bone morphogenetic protein 4 commits mesenchymal stem cells to the adipose lineage...
- Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorP Tontonoz
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
Cell 79:1147-56. 1994....
- Chemerin is a novel adipokine associated with obesity and metabolic syndromeKiymet Bozaoglu
Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
Endocrinology 148:4687-94. 2007..obesus. Fractionation of P. obesus adipose tissue confirmed that chemerin was predominantly expressed in adipocytes, whereas CMKLR1 was expressed in both adipocytes and stromal-vascular cells of adipose tissue...
- Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytesMarica Bordicchia
Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
J Clin Invest 122:1022-36. 2012..mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat depots...
- Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsVictoria Rotter
Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
J Biol Chem 278:45777-84. 2003..To examine putative mechanisms and cross-talk with insulin, 3T3-L1 adipocytes were cultured for different times with IL-6 and tumor necrosis factor alpha (TNF-alpha)...
- Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosisVioleta Arsenescu
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
Environ Health Perspect 116:761-8. 2008..However, the effects of PCBs on adipocytes, obesity, and obesity-associated cardiovascular disease are unknown.
- Cellular hypoxia and adipose tissue dysfunction in obesityI Stuart Wood
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Proc Nutr Soc 68:370-7. 2009..Studies in animal models (mutant mice, diet-induced obesity) and cell-culture systems (mouse and human adipocytes) have provided strong support for a role for hypoxia in modulating the production of several inflammation-..
- Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophagesMartina I Lefterova
University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
Mol Cell Biol 30:2078-89. 2010..is whether PPARgamma binding in macrophages occurs at genomic locations the same as or different from those in adipocytes. Here, utilizing chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq), we demonstrate that ..
- Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acidsMohamed S Zaibi
Clore Laboratory, University of Buckingham, Buckingham, UK
FEBS Lett 584:2381-6. 2010..deaminase to minimise Galpha(i) signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild-type but not GPR41 knockout mice. Expression of GPR43 was reduced in GPR41 knockout mice...
- Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosisNaim Alkhouri
Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Biol Chem 285:3428-38. 2010..Inhibition of adipocyte apoptosis may be a new therapeutic strategy for the treatment of obesity-associated metabolic complications...
- Expression cloning and characterization of a novel adipocyte long chain fatty acid transport proteinJ E Schaffer
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 79:427-36. 1994..We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed in cultured cells, augments uptake of LCFAs...
- Characterization of a human preadipocyte cell strain with high capacity for adipose differentiationM Wabitsch
Department of Pediatrics, University of Ulm, Ulm, Germany
Int J Obes Relat Metab Disord 25:8-15. 2001..To develop and to characterize a human preadipocyte cell strain with high capacity for adipose differentiation serving as a model for studying human adipocyte development and metabolism in vitro...
- Adipose tissue: from lipid storage compartment to endocrine organPhilipp E Scherer
Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Diabetes 55:1537-45. 2006..While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors ..
- Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic programS Muruganandan
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
Cell Mol Life Sci 66:236-53. 2009Bone marrow mesenchymal stem cells (MSCs) are multipotent cells, which among other cell lineages, give rise to adipocytes and osteoblasts...
- Adipocyte turnover: relevance to human adipose tissue morphologyErik Arner
Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Diabetes 59:105-9. 2010Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology.
- Mesenchymal stem cells in the Wharton's jelly of the human umbilical cordHwai Shi Wang
Institute of Anatomy and Cell Biology, Yang Ming University, Taipei, Taiwan, Republic of China
Stem Cells 22:1330-7. 2004....
- Obesity and the role of adipose tissue in inflammation and metabolismAndrew S Greenberg
Obesity and Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston 02111 1524, USA
Am J Clin Nutr 83:461S-465S. 2006Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion that adipocytes are simply a storage depot for body energy...
- Dynamics of fat cell turnover in humansKirsty L Spalding
Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Nature 453:783-7. 2008..fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells (adipocytes) is thought to be most important...
- Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cyclingEric Festa
Department of Molecular Biology, Yale University, 219 Prospect St, New Haven, CT 06520, USA
Cell 146:761-71. 2011..These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically...
- Adipogenesis: from stem cell to adipocyteQi Qun Tang
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Annu Rev Biochem 81:715-36. 2012..factors that induce conversion of mesenchymal stem cells (MSCs) to preadipocytes that differentiate into adipocytes. MSCs, which are recruited from the vascular stroma of adipose tissue, provide an unlimited supply of adipocyte ..
- A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolismMark A Herman
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 484:333-8. 2012..ChREBP-β expression in human adipose tissue predicts insulin sensitivity, indicating that it may be an effective target for treating diabetes...
- Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesityViviane Zorzanelli Rocha
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA
Circ Res 103:467-76. 2008..These results indicate a role for T cells and IFNgamma, a prototypical T-helper 1 cytokine, in regulation of the inflammatory response that accompanies obesity...
- MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiationFrancisco J Ortega
Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN CB06 03 0010, Girona, Spain
PLoS ONE 5:e9022. 2010..the aim of this study was to investigate whether miRNA pattern in human fat cells and subcutaneous adipose tissue is associated to obesity and co-morbidities and whether miRNA expression profile in adipocytes is linked to adipogenesis.
- Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cellsRana K Gupta
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell Metab 15:230-9. 2012..Zfp423(GFP) mice represent a simple tool for the specific localization and isolation of molecularly defined preadipocytes from distinct adipose tissue depots...
- Mitochondrial biogenesis in mammals: the role of endogenous nitric oxideEnzo Nisoli
Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
Science 299:896-9. 2003Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells...
- Adipocytes as regulators of energy balance and glucose homeostasisEvan D Rosen
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 444:847-53. 2006b>Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways...
- miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expressionSang Yun Kim
Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Seoul, Republic of Korea
Biochem Biophys Res Commun 392:323-8. 2010..Ectopic expression of miR-27a in 3T3-L1 pre-adipocytes repressed adipocyte differentiation by reducing PPARgamma expression...
- Apelin, a newly identified adipokine up-regulated by insulin and obesityJeremie Boucher
Institut National de la Santé et de la Recherche Médicale Unité 586, Institut Fédératif de Recherche 31, Centre Hospitalier Universitaire Rangueil, BP 84225 F 31432 Toulouse Cedex 4, France
Endocrinology 146:1764-71. 2005The results presented herein demonstrate that apelin is expressed and secreted by both human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other cell types present in white adipose tissue or other organs ..
- Obesity and metabolic syndrome in circadian Clock mutant miceFred W Turek
Department of Neurology, Northwestern University, Evanston, IL 60208, USA
Science 308:1043-5. 2005..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
- Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytesChun lin Gao
Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing 210004, China
Mol Cell Endocrinol 320:25-33. 2010..However, their roles in mitochondrial dysfunction of white adipocytes are not well-studied...
- Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesityNoriyuki Ouchi
Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
Science 329:454-7. 2010..Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue.
- Insulin-sensitive obesityNora Kloting
Department of Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany
Am J Physiol Endocrinol Metab 299:E506-15. 2010..This suggests that mechanisms beyond a positive caloric balance such as inflammation and adipokine release determine the pathological metabolic consequences in patients with obesity...
- Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesisRasmus Siersbæk
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
EMBO J 30:1459-72. 2011....
- Both adiponectin and interleukin-10 inhibit LPS-induced activation of the NF-κB pathway in 3T3-L1 adipocytesFabio Santos Lira
Departamento de Fisiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Cytokine 57:98-106. 2012Adiponectin and interleukin 10 (IL-10) are adipokines that are predominantly secreted by differentiated adipocytes and are involved in energy homeostasis, insulin sensitivity, and the anti-inflammatory response...
- Adipose tissue and adipocytes support tumorigenesis and metastasisKristin M Nieman
Department of Obstetrics and Gynecology, Center for Integrative Science, University of Chicago, Chicago, IL, USA
Biochim Biophys Acta 1831:1533-41. 2013..In this activated state, adipocytes and inflammatory cells secrete adipokines and cytokines which are known to promote tumor development...
- SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytesTong Shi
United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 280:13560-7. 2005..Enforced expression of SIRT3 in the HIB1B brown adipocytes enhances the expression of the uncoupling protein PGC-1alpha, UCP1, and a series of mitochondria-related genes...
- Inflammation, stress, and diabetesKathryn E Wellen
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 115:1111-9. 2005..We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease...
- FGF-21 as a novel metabolic regulatorAlexei Kharitonenkov
Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
J Clin Invest 115:1627-35. 2005..FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes. FGF-21-transgenic mice were viable and resistant to diet-induced obesity...
- Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytesKolapo M Ajuwon
Department of Animal Sciences, Center for Comparative Medicine, Purdue University, West Lafayette, IN 47907 2054, USA
J Nutr 135:1841-6. 2005..e., activates proinflammatory pathways) in myotubes, the effects of fatty acids on inflammatory processes in adipocytes have not been established...
- Physiological role of PRDM16 in brown fat development and energy balancePatrick Seale; Fiscal Year: 2011Aim 1: We test the hypothesis that PRDM16 can drive the formation of functional brown adipocytes in white fat depots of mice to raise energy expenditure and protect against obesity and cold exposure. Diet-Induced Obesity (DIP)...
- Donald A McClain; Fiscal Year: 2016..The effects of glucose on hepcidin, and subsequent effects on inflammatory signaling in macrophages and adipocytes, will be examined in mouse models with normal glucose tolerance, hyperphagia, diabetes, and with genetic ..
- David A Bernlohr; Fiscal Year: 2014..These studies in sum lead to our central hypothesis: decreased expression of GSTA4 in adipocytes leads to increased carbonylation of multiple protein targets...
- Osteocalcin and Metabolic Risk Factors. The Framingham StudyYi Hsiang Hsu; Fiscal Year: 2011..However, the underlying mechanisms for how OC interacting with adipocytes, pancreatic 2 cells and other molecules functionally involved in glucose homeostasis are still unclear...
- Fredric B Kraemer; Fiscal Year: 2016..of LDs within normal adipocytes and within adipocytes in which specific LD-associated proteins have been manipulated by gene targeting...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..To achieve this goal, we first explore the impact of PM2.5 exposure on white and brown adipocytes and associated vascular dysfunction in transgenic mice expressing yellow fluorescent protein (YFP) under the ..
- David A Bernlohr; Fiscal Year: 2016..acid binding proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages...
- Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver DiseaseFrank A Anania; Fiscal Year: 2010..These peptides have pleotropic effects including stimulating growth of b cells of the pancreas and action on adipocytes. To date there is limited data about a direct role of GLP-1 in hepatocytes...
- The Somatotropic Axis and Health Aging: A Search for MechanismsAndrzej Bartke; Fiscal Year: 2013..Project 3 will study mechanisms of stress resistance in fibroblasts and pre-adipocytes and evaluate longevity and age-sensitive traits in novel mutant mice developed in Project 2...
- Mitochondrial Dysfunction and Adipose Insulin ResistanceDAVID BERNLOHR; Fiscal Year: 2009..These studies in sum lead to our central hypothesis: decreased expression of GSTA4 in adipocytes leads to increased mitochondrial protein carbonylation...
- Robert V Farese; Fiscal Year: 2016DESCRIPTION (provided by applicant): Insulin stimulates glucose transport in muscle and adipocytes, and lipid synthesis in liver by activating atypical protein kinase C (aPKC) and Akt (PKB)...
- Chronic stress mediates fat-related changes in insulin signaling and gut motilityCHARALABOS contact POTHOULAKIS; Fiscal Year: 2010..we have demonstrated the ability of these neuropeptides not only to induce pro-inflammatory signaling in adipocytes, but also to affect their response to insulin...
- Prolactin as a Growth Factor in Breast CancerNira Ben-Jonathan; Fiscal Year: 2013..The human breast receives PRL input from two sources: the pituitary and local. Within the breast, stromal adipocytes produce significantly more PRL than epithelial cells, and both are under tonic inhibition...
- Papasani V Subbaiah; Fiscal Year: 2016..will first determine the incorporation profiles of different CLA isomers into membranes of cultured hepatocytes, adipocytes, and myocytes of human and mouse origins...
- AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2014..growth and aggressiveness of metastatic prostate cancer in the bone is driven by the CTSK-expressing bone marrow adipocytes and the adipocyte- driven inflammation involving CXCL1 and CXCL2 chemokines...
- Catherine M Gordon; Fiscal Year: 2015..hormonal abnormalities in girls with AN influence mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts...
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2011Fatty acid binding proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages...
- CLIFFORD JAMES ROSEN; Fiscal Year: 2015..In WAT depots, Misty had brown-like adipocytes suggesting that the SNS is compensating for loss of BAT but that the SNS drive may also be causing age-related ..
- Hematopoietic Stem Cell Transplantation in Osteogenesis ImperfectaMeenal Mehrotra; Fiscal Year: 2012..cells like mast cells and osteoclasts, while MSCs generate a number of mesenchymal cells including fibroblasts, adipocytes, chondrocytes and osteoblasts...
- Sihem Boudina; Fiscal Year: 2016..To address this, we generated mice with increased superoxide production in adipocytes through deletion of manganese superoxide dismutase (MnSOD), the sole enzyme responsible for detoxifying ..
- Use of umbilical cord as a unique stem cell source for tissue regenerationXiao Dong Chen; Fiscal Year: 2013..layers in vitro under conditions known to induce commitment to a specific cell lineage, including osteoblasts, adipocytes, chondroblasts and cardiomyocytes (mesoderm), nerve (ectoderm) and hepatocytes (endoderm)...
- Anthony W Ferrante; Fiscal Year: 2016..tissue development, metabolism and endocrine function are essential for the efficient storage of lipids in adipocytes and for normal systemic metabolism...
- The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and ObesityYanjun Liu; Fiscal Year: 2013..to regulation of 12-HSD1 amplifying GC regeneration by using siRNA technology in intact mouse hepatocytes and adipocytes. These cell culture studies will be reinforced by treatment of animals with specific H6PDH or G6PT siRNA in a ..
- Min Du; Fiscal Year: 2014..Myocytes, adipocytes and fibroblasts in fetal SM are derived from mesenchymal stem cells (MSC)...
- Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine ZipperXing Ming Shi; Fiscal Year: 2012..osteogenic differentiation of bone marrow progenitor cells, the common precursors of fat- and bone-forming adipocytes and osteoblasts...
- Sharona E Gordon; Fiscal Year: 2016..One of the best-studied examples, trafficking of the Glut4 glucose transporter to the plasma membrane of adipocytes and muscle cells in response to insulin, has revealed a number of important players on which we based our model ..
- Endoplasmic Reticulum Chaperone as a Regulator of Obesity and DiabetesAmy S Lee; Fiscal Year: 2010..upregulated in adipose tissue of HFD-fed Grp78 mice in adipocyte metabolic function, utilizing primary adipocytes and MEFs from the Grp78 and mice, as well as the 3T3-L1 adipocyte culture system...
- Effect of exposure to organochlorine compounds on the development of obesity andGEORGE E HOWELL; Fiscal Year: 2011..that exposure to DDE decreases adipogenesis while increasing the release of leptin and interleukin-6 from adipocytes. Thus, the effect of DDE and oxychlordane exposure on expression and function of adipogenic genes will be ..
- The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life CourseERIC contact LOUCKS; Fiscal Year: 2010..Specific analytic objectives include: (a) to investigate if DNA methylation in subcutaneous adipocytes is associated with measures of adiposity derived from DEXA scans, CT lumbar region scans (to assess visceral fat)..
- David E Cohen; Fiscal Year: 2016..Aim 2 will utilize indirect calorimetry, as well as cultured primary brown adipocytes in order to assess whether PC-TP-Them2 interactions limit mitochondrial fatty acid oxidation...
- KELLY ANNE BURKE; Fiscal Year: 2014..Aim 1 will investigate 2D and 3D co-cultures of human adipocytes with endothelial cells to establish baseline differences in structure and function of the co- cultures in the ..
- Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor PatientsRaymond P Perez; Fiscal Year: 2010..we will test the hypothesis that tolerable doses of CLA inhibit expression of S14 mRNA in normal human adipocytes and in tumor biopsies from patients with advanced solid tumors...
- Frederick S vom Saal; Fiscal Year: 2016..elevated insulin as well as an increase in total abdominal fat weight, but have markedly fewer gonadal fat pad adipocytes and markedly different gene expression profiles relative to equally obese macrosomic mice...
- Group X sPLA2: Regulator of lipolysis and glucose homeostasisNancy R Webb; Fiscal Year: 2013..This will be achieved by a) determining whether GX sPLA2 alters the rate of TAG synthesis or hydrolysis in adipocytes;and b) determining whether GX sPLA2 promotes TAG mobilization by activating hormone sensitive lipase...
- Novel Small Molecule Therapeutics to Treat ObesitySUSAN MEDGHALCHI; Fiscal Year: 2010..inhibit GPAT activity in mitochondrial preparations, (b) preferentially inhibit triglyceride synthesis in 3T3-L1 adipocytes, (c) reversibly reduce weight and food intake in chronic treatment of DIO mice without toxicity, (d) increase ..
- Lipocalin 2 in Inflammation and Metabolic ControlXiaoli Chen; Fiscal Year: 2012..and antagonize TNF( effects on glucose metabolism, PPAR( gene expression and insulin resistance in 3T3- L1 adipocytes. Moreover, LCN2 suppresses TNF(- and LPS-induced cytokine/chemokine production in adipocytes as well as ..
- Depression, Adipocytokines and Metabolic Dysregulation in Black and White WomenSusan A Everson Rose; Fiscal Year: 2010..is systematic study of the association between depression and adipocytokines, secretory proteins released from adipocytes that play a critical role in the inflammatory process and are identified as highly significant in atherogenesis ..
- Jane F Reckelhoff; Fiscal Year: 2015..HAF rats have increased plasma leptin, a cytokine released from adipocytes, that contributes to SNS activation and increases BP by stimulating brain pro-opiomelanocortin pathway via ..
- Sympathetic Regulation of AMPK in the control of non-shivering thermogenesisJacob D Mulligan; Fiscal Year: 2012..patients and age/sex matched controls, the hypothesis that desensitization of adrenergic signaling in white adipocytes is associated with a downregulation of 11 AMPK activity will be tested...
- INSULIN ACTION IN MUSCLE AND FAT CELLSJAMES CARLTON GARRISON; Fiscal Year: 2010..Lentivirus will be used to overexpress rictor or to express shRNA to knockdown rictor in 3T3-L1 adipocytes. To investigate mTORC2 function in vivo, we propose to knockout rictor in adipocytes and skeletal muscle of mice. ..
- Adipocyte Renin-Angiotensin System and Programming of HypertensionMina Desai; Fiscal Year: 2010..When allowed catch-up growth during the nursing period, the MFR offspring develop hypertrophic adipocytes in concert with increased adipose gene expression of AGT, AT2 and renin...
- RAYMOND EDWARD SOCCIO; Fiscal Year: 2016..sequencing (ChIP-Seq) to identify the genome-wide binding sites, or cistrome, for PPAR in cultured human adipocytes. We found tens of thousands of binding sites, showing the power of cistromics to yield enormous amounts of ..
- The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland DevelopBUFFY SUE ELLSWORTH; Fiscal Year: 2010..FOXO1 inhibits proliferation and regulates differentiation and migration of pancreatic 2-cells, myoblasts, adipocytes, and endothelial cells. To test this hypothesis we propose three specific aims: Specific Aim 1...
- Timothy E Graham; Fiscal Year: 2016..Such observations led to speculations that inhibiting autophagy in adipocytes might provide a promising strategy for treating or preventing obesity and its metabolic consequences...
- Joseph Avruch; Fiscal Year: 2016..We will also determine how TOR complex 1 controls the translation of RNAs that bind to the protein IMP2, variants of whose gene appear to confer susceptibility to type 2 diabetes. ..
- Lu Qi; Fiscal Year: 2016..Fatty acid binding protein 4 (FABP4), the lipid binding protein for both adipocytes and macrophages, is an important regulator of lipid and inflammatory cascades...
- FUNCTION AND REGULATION OF OSTEONECTIN IN BONEAnne M Delany; Fiscal Year: 2013..Mesenchymal stem cells (MSCs) give rise to both osteoblasts and adipocytes, and MSC lineage allocation is altered in aging...
- Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte dPartha S Sinha; Fiscal Year: 2011DESCRIPTION (provided by applicant): Adipocytes and osteoblasts may share a common precursor residing in the bone marrow...
- CHAD ALBERT COWAN; Fiscal Year: 2016..In contrast, mutations in the PLIN1 gene appear to cause a more uniform reduction of adipocytes in all depots...
- Jacqueline M Stephens; Fiscal Year: 2016b>Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrates. Obesity is the primary disease of fat cells and the most common metabolic disorder in the industrial world...
- Effect of constitutive Type 2 NF-kB on adipogenesisLOTUS KYI LOO; Fiscal Year: 2010..found that both LBW242 and SM can inhibit PPAR gamma (master regulator of adipogenesis), C/EBPo and downstream adipocytes specific genes...
- Robert Farese; Fiscal Year: 2014..a) defined upstream activators of atypical protein kinase C (aPKC) and Akt during insulin action in muscle, adipocytes and liver and (b) showed that aPKC is required for insulin-stimulated increases in glucose transport in muscle ..
- Seahorse XF96 Extracellular Flux AnalyzerEnrique Saez; Fiscal Year: 2013..of cells and organisms used to model physiological and pathological processes (including primary hepatocytes, adipocytes, neurons, cardiomyocytes, cancer cells, myotubes, and worms)...
- The Regulation of Mitochondrial Function by SIRT3Qiang Tong; Fiscal Year: 2010..leading to an up-regulation of the expressions of PPARgamma coactivator PGC-1 alpha and UCP-1 in brown adipocytes or UCP3 in myocytes...
- Timothy E McGraw; Fiscal Year: 2016..We will create mice that overexpress or lack ChREBP selectively in adipocytes. Aim 1 is to determine whether increased expression of ChREBP selectively in adipocytes is sufficient to enhance ..
- Jennifer J Loros; Fiscal Year: 2015..In Specific Aim 3, we will use RNA sequencing to determine the circadian profile of clock-controlled genes in adipocytes of wt and RIP140 knockout cells, and will use chromatin immunoprecipitation of RIP140 in adipocytes to begin to ..
- Sean Hartig; Fiscal Year: 2015..Thus, the ability of adipocytes to store energy as lipids is a crucial component of T2DM, and their production of key metabolic adipokines to ..
- Role of Gsalpha in Regulating Osteoblast DifferentiationJOY Y WU; Fiscal Year: 2012..Finally, Aim 3 will focus on determining the ability of osteoprogenitors to differentiate towards other mesenchymal lineages such as adipocytes, using lineage tracing in vivo and cell differentiation assays in vitro.
- Environmental arsenic and diabetes mellitusMiroslav Styblo; Fiscal Year: 2012..are more potent than iAs as inhibitors of insulin signaling and insulin-stimulated glucose uptake in cultured adipocytes. Notably, concentrations of arsenicals that inhibit glucose uptake by adipocytes and arsenic concentrations in ..
- Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinasesSheila Collins; Fiscal Year: 2009..All 3 known [unreadable]AR subtypes are expressed in adipocytes, and [unreadable]ARs are coupled to increases in intracellular cAMP and activation of cAMP-dependent protein ..
- Philipp E Scherer; Fiscal Year: 2016..be collaborating with Phil Scherer on defining the differential transcriptional control of lipogenic pathways in adipocytes and vagal sensory neurons and Jay Horton who will direct the Metabolic Phenotyping Core...
- VIJAY PREM SINGH; Fiscal Year: 2016..To understand this mechanistically, we generated a novel acinar-adipocyte co-culture system. While acini and adipocytes functioned normally in this medium both individually and together in the presence of the lipase inhibitor ..
- ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTIONHarvey Lodish; Fiscal Year: 2007In general, the PI will attempt to define multiple endo-/exocytotic compartments in 3T3-L1 adipocytes including vesicles which transport membrane associated proteins like GLUT4, secreted proteins where secretion is stimulated by insulin ..
- Imaging evidence: Is there competition between marrow fat and bone?Wei Shen; Fiscal Year: 2010Osteoporosis is one of the leading health problems in the United States. Recent studies suggest that adipocytes in bone marrow and osteoblasts share the same precursor, mesenchymal stem cells (MSC). Human imaging studies [i.e...
- Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast CancerGlendon M Zinser; Fiscal Year: 2010..research and cancer prevention, offering a nutritional means of therapy with 25(OH)D3, bioactivated by the adipocytes and localizing therapy to breast tissue...
- Transcription & Function of Adipocyte Beta3AR in ObesitySheila Collins; Fiscal Year: 2006..to potent stimulation of lipolysis, beta3AR agonists promote the appearance of thermogenically active brown adipocytes in typical white adipose depots but the mechanism responsible for this effect is not understood...
- REGULATION OF LDL RECEPTORS IN ADIPOCYTESFREDRIC KRAEMER; Fiscal Year: 1993..much progress has been made in elucidating the pathways regulating cholesterol uptake and storage in most cells, adipocytes have not been well investigated...
- TONIC ACTIVITY OF ADENOSINE A1-ADENOSINE RECEPTORSJohn Shryock; Fiscal Year: 2003..in white adipose tissue are tonically active and treatment with antagonists of the A1- adenosine receptors in adipocytes are spontaneously active and cause inhibition of lipolysis even in the absence of an agonist, (2) there is a ..
- BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTESSheila Collins; Fiscal Year: 2003..to potent stimulation of lipolysis, beta3AR agonists promote the appearance of thermogenically active brown adipocytes in typical white adipose depots but the mechanism responsible for this effect is not understood...
- ADENOSINE RECEPTOR REGULATION AND INSULIN ACTIONAllan Green; Fiscal Year: 1992Endogenous adenosine can markedly potentiate the effects of insulin, in isolated adipocytes. This is thought to be mediated via A1 adenosine receptors, which are coupled to inhibition of adenylate cyclase (and possibly other effector ..