eflornithine

Summary

Summary: An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.

Top Publications

  1. pmc A molecular mechanism for eflornithine resistance in African trypanosomes
    Isabel M Vincent
    University of Glasgow, Glasgow, UK
    PLoS Pathog 6:e1001204. 2010
  2. pmc Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei
    Isabel M Vincent
    The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 6:e1618. 2012
  3. ncbi Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
    Gerardo Priotto
    Epicentre, Paris, France
    Lancet 374:56-64. 2009
  4. ncbi Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters
    Gabriela Schumann Burkard
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Mol Biochem Parasitol 175:91-4. 2011
  5. ncbi Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 281:19387-94. 2006
  6. pmc Independent roles of eIF5A and polyamines in cell proliferation
    Kazuhiro Nishimura
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Biochem J 385:779-85. 2005
  7. pmc Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
    Nicola Baker
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 176:55-7. 2011
  8. ncbi Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis
    O Heby
    Department of Molecular Biology, Umea University, Umea, Sweden
    Amino Acids 33:359-66. 2007
  9. ncbi Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 7:433-44. 2005
  10. ncbi NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells
    L Li
    Department of Surgery, University of Maryland School of Medicine, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 280:G992-G1004. 2001

Research Grants

Detail Information

Publications201 found, 100 shown here

  1. pmc A molecular mechanism for eflornithine resistance in African trypanosomes
    Isabel M Vincent
    University of Glasgow, Glasgow, UK
    PLoS Pathog 6:e1001204. 2010
    ..Its causative agent is the protozoan parasite Trypanosoma brucei. Eflornithine is used as a first line treatment for human African trypanosomiasis, but there is a risk that resistance could ..
  2. pmc Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei
    Isabel M Vincent
    The Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 6:e1618. 2012
    ..b>Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ..
  3. ncbi Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
    Gerardo Priotto
    Epicentre, Paris, France
    Lancet 374:56-64. 2009
    ..We assessed the efficacy and safety of nifurtimox-eflornithine combination therapy (NECT) for second-stage disease compared with the standard eflornithine regimen.
  4. ncbi Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters
    Gabriela Schumann Burkard
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Mol Biochem Parasitol 175:91-4. 2011
    ..RNAi induction and selection of resistant parasites was performed in the presence of melarsoprol or eflornithine. The former led to the isolation of the adenosine transporter TbAT1, which is known to be involved in ..
  5. ncbi Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 281:19387-94. 2006
    ..These results indicate that polyamines modulate cytoplasmic HuR levels in intestinal epithelial cells, in turn controlling the stability of the NPM and p53 mRNAs and influencing NPM and p53 protein levels...
  6. pmc Independent roles of eIF5A and polyamines in cell proliferation
    Kazuhiro Nishimura
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Biochem J 385:779-85. 2005
    ..The results show that a decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth..
  7. pmc Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
    Nicola Baker
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 176:55-7. 2011
    ..Nifurtimox-Eflornithine Combination Therapy (NECT) was recently introduced for Human African Trypanosomiasis and we focus on these ..
  8. ncbi Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis
    O Heby
    Department of Molecular Biology, Umea University, Umea, Sweden
    Amino Acids 33:359-66. 2007
    ..By taking advantage of the differences in enzyme structure between parasite and host, it should be possible to design new drugs that can selectively kill the parasites...
  9. ncbi Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 7:433-44. 2005
    ..Therefore, Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention...
  10. ncbi NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells
    L Li
    Department of Surgery, University of Maryland School of Medicine, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 280:G992-G1004. 2001
    ..These findings suggest that increased NF-kappaB activity after polyamine depletion has a proapoptotic or antiapoptotic effect on intestinal epithelial cells determined by the nature of the death stimulus...
  11. ncbi Development of difluoromethylornithine (DFMO) as a chemoprevention agent
    F L Meyskens
    Department of Medicine Hematology Oncology, and Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange 92668 2675, USA
    Clin Cancer Res 5:945-51. 1999
    ..g., colon polyp recurrence) of carcinogenesis in patient populations at elevated risk for the development of specific epithelial cancers, including colon, esophageal, breast, cutaneous, and prostate malignancies...
  12. ncbi Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Biochem 103:1046-52. 2008
    ..These results suggest that polyamine depletion can represent a useful strategy to improve MSC differentiation into the cardiac lineage, especially in the presence of cardiomyocytes damaged by an ischemic environment...
  13. ncbi Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion
    Huifang M Zhang
    Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    J Biol Chem 279:22539-47. 2004
    ..These results indicate that polyamine depletion induces the Akt activation mediating suppression of apoptosis via inhibition of caspase-3 in normal intestinal epithelial cells...
  14. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
    ..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations...
  15. pmc Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion
    Lan Xiao
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 403:573-81. 2007
    ..These results indicate that induced JunD in IECs represses CDK4 transcription through its proximal promoter region following polyamine depletion...
  16. pmc Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma
    Dana Lynn T Koomoa
    Cancer Research Center of Hawaii, Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9825-31. 2008
    ..This study presents new information that may explain the moderate efficacy of DFMO monotherapy in clinical trials and reveals potential new targets for DFMO-based combination therapies for NB treatment...
  17. pmc Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis
    Antoaneta Y Sokolova
    Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Antimicrob Agents Chemother 54:2893-900. 2010
    The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis (HAT) has renewed interest in the potential of nitro drugs as chemotherapeutics...
  18. pmc The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation
    Guy Landau
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76199, Israel
    J Biol Chem 285:12474-81. 2010
    ..Finally, we show that either polyamine depletion or GC7 treatment induced eIF2alpha phosphorylation and reduced phosphorylation of 4E-BP, thus setting the molecular basis for the observed inhibition of translation initiation...
  19. ncbi Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype
    D L Kramer
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Res 61:7754-62. 2001
    ....
  20. ncbi Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice
    Andrea Manni
    Departments of Medicine, Pennsylvania State University College of Medicine, Pennsylvania, USA
    Clin Exp Metastasis 20:321-5. 2003
    ..These data provide a rationale for testing the efficacy of anti-PA treatment within the context of adjuvant therapy of breast cancer...
  21. pmc In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness
    Caecilia Schmid
    Department of Medicines Research, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1920. 2012
    ..Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and insufficiently effective in certain areas (melarsoprol)...
  22. pmc Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial
    J Pepin
    Centre de santé internationale, Universite de Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
    Bull World Health Organ 78:1284-95. 2000
    A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ..
  23. ncbi Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo
    Gerardo Priotto
    Epicentre, Paris, France
    Clin Infect Dis 45:1435-42. 2007
    ..We compared the efficacy and safety of the nifurtimox-eflornithine drug combination with the standard eflornithine regimen for the treatment of second-stage disease.
  24. ncbi Protective role of arginase in a mouse model of colitis
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, School of Medicine, University of Maryland, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 173:2109-17. 2004
    ..Modulation of the balance of iNOS and arginase, and of the arginase-ODC metabolic pathway may represent a new strategy for regulating intestinal inflammation...
  25. pmc A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer
    Howard H Bailey
    University of Wisconsin Paul P Carbone Cancer Center, Madison, USA
    Cancer Prev Res (Phila) 3:35-47. 2010
    ..069) in new NMSC that was predominantly due to a marked reduction in new BCC. Based on these data, the potential of DFMO, alone or in combination, to prevent skin cancers should be explored further...
  26. pmc Polyamines regulate gap junction communication in connexin 43-expressing cells
    L Shore
    CRC Beatson Laboratories, Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Biochem J 357:489-95. 2001
    ..This regulation is dependent upon the expression of connexin 43 (Cx43 or Cxalpha1), which is a major connexin expressed in many different cell types, and involves an increase in Cx43 and its cellular re-distribution...
  27. pmc The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain
    Lisa Sanderson
    Pharmaceutical Sciences Research Division, King s College London, London, UK
    J Neurochem 107:1136-46. 2008
    ..New drugs are urgently being sought. Although the existing drug, eflornithine, is assumed to reach the brain in high concentrations, little is known about how it crosses the healthy and ..
  28. pmc Multiple active conformers of mouse ornithine decarboxylase
    S E Tsirka
    Department of Microbiology and Immunology, University of California San Francisco 94143
    Biochem J 293:289-95. 1993
    ....
  29. ncbi Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo
    Emilie Alirol
    Division of International and Humanitarian Medicine, University Hospitals of Geneva, Switzerland
    Clin Infect Dis 56:195-203. 2013
    ..The recent development of nifurtimox-eflornithine combination therapy (NECT) has brought new hopes for patients in the second stage...
  30. pmc A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity
    Sarah M Kreul
    University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA
    Cancer Prev Res (Phila) 5:1368-74. 2012
    ..107, P = 0.43) are listed. Follow-up data revealed a persistent but insignificant reduction in new NMSCs occurring in DFMO subjects without evidence of latent or cumulative toxicity relative to placebo subjects...
  31. ncbi Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes
    Manica Balasegaram
    Médecins Sans Frontières United Kingdom, 67 74 Saffron Hill, London EC1N 8QX, UK
    Trans R Soc Trop Med Hyg 103:280-90. 2009
    ..Regimens included eflornithine and standard- and short-course melarsoprol...
  32. pmc Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment
    Monica M Richert
    Department of Pathology, Comprehensive Cancer Center, National Foundation for Cancer Research Center for Metastasis Research, University of Alabama at Birmingham, Alabama, USA
    Breast Cancer Res 7:R819-27. 2005
    ..This study tested the effects of DFMO on orthotopic tumor growth and lung colonization of another breast cancer cell line (MDA-MB-231) and the effects on bone metastasis of MDA-MB-435 cells...
  33. ncbi Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells
    Andrea Manni
    Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Clin Exp Metastasis 21:461-7. 2004
    ..In summary, our results show that the increase in ERK phosphorylation induced by DFMO plays a critical role in the anti-invasive action of the drug and in its ability to upregulate TSP-1 production...
  34. ncbi Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine
    N Yarlett
    Haskins Laboratories, Department of Biology, Pace University, New York, NY 10038
    J Gen Microbiol 137:717-24. 1991
    ..The possible role of the enzyme in morphological control and its potential as a chemotherapeutic target are discussed...
  35. ncbi Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells
    John Yoonkeun Jun
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA
    Breast Cancer Res Treat 105:29-36. 2007
    ..The failure of DFMO to inhibit pulmonary metastasis in this system appears to be due, at least in part, to its lack of anti-proliferative effect at the metastatic sites...
  36. ncbi The change of antizyme inhibitor expression and its possible role during mammalian cell cycle
    Yasuko Murakami
    Research Institute of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishi Tokyo, Tokyo 202 8585, Japan
    Exp Cell Res 315:2301-11. 2009
    ..These findings suggested that AIn contributed to a rapid increase in ODC at the G1 phase and also played a role in facilitating cells to complete mitosis during the cell cycle...
  37. ncbi Astroglia growth retardation and increased microglia proliferation by lithium and ornithine decarboxylase inhibitor in rat cerebellar cultures: Cytotoxicity by combined lithium and polyamine inhibition
    Gad M Gilad
    G and V Gilad Ltd, Tel Aviv, Israel
    J Neurosci Res 85:594-601. 2007
    ..This implies that direct effects on astrocytes and microglia may contribute to the effects of lithium on neurons...
  38. ncbi Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats
    Neeraj Gupta
    Department of Anatomy, University of Otago, Dunedin, New Zealand
    Pharmacol Biochem Behav 100:464-73. 2012
    ..These findings merit further investigation to fully understand the functional role of endogenous polyamines in learning and memory...
  39. ncbi Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats
    N Gupta
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Neuroscience 161:691-706. 2009
    ..The spermidine/spermine and glutamate/GABA ratios in hippocampal DG are strongly associated with anxiety-like behavior in the DFMO rats...
  40. ncbi Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion
    Cuneyt Temiz
    Department of Neurosurgery, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
    J Clin Neurosci 12:449-52. 2005
    ....
  41. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
    ..Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues...
  42. ncbi Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites
    R Poulin
    Department of Cellular and Molecular Physiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033
    J Biol Chem 267:150-8. 1992
    ..This adduct is consistent with spectral evidence showing that inactivation of the enzyme with DFMO does not entail the formation of a stable adduct between the pyridoxal 5'-phosphate, the enzyme, and the inhibitor...
  43. ncbi Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda
    E Matovu
    Livestock Health Research Institute, Tororo, Uganda
    Trop Med Int Health 6:407-11. 2001
    ..From our findings it appears that reduced drug susceptibility may be one factor for the frequent relapses of sleeping sickness after melarsoprol treatment occurring in Northwest Uganda...
  44. pmc Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients
    Jason A Zell
    Chao Family Comprehensive Cancer Center, Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    J Natl Cancer Inst 102:1513-6. 2010
    ..We investigated the effects of ODC1 after treatment with difluoromethylornithine (eflornithine)/sulindac or placebo...
  45. ncbi Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation
    Cheryl A Hobbs
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Exp Cell Res 290:427-36. 2003
    ..The abnormal chromatin environment fostered by elevated levels of polyamines may be a necessary prerequisite for epithelial tumor growth and maintenance...
  46. pmc Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo
    Manica Balasegaram
    Medecins Sans Frontieres, London, England
    Bull World Health Organ 84:783-91. 2006
    To compare the effectiveness of melarsoprol and eflornithine in treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
  47. ncbi A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 8:3105-17. 2002
    ..DFMO is an irreversible inhibitor of ornithine decarboxylase, the limiting enzyme of polyamine synthesis that is often up-regulated in breast cancer...
  48. ncbi Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation
    L Li
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 281:C941-53. 2001
    ....
  49. pmc Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system
    Denis Soulet
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2
    J Cell Biol 162:257-68. 2003
    ..Thus, polyamines have a major impact on the neuronal integrity and cerebral homeostasis during immune insults...
  50. ncbi Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
    ..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...
  51. pmc Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme
    Anupam Jhingran
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    PLoS Negl Trop Dis 2:e115. 2008
    ..Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is a highly regulated enzyme...
  52. ncbi A novel role for polyamines in adult neurogenesis in rodent brain
    Jordane Malaterre
    CNRS, Laboratoire NMDA, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Eur J Neurosci 20:317-30. 2004
    ..The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebrate species...
  53. ncbi Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair
    John E Wolf
    Baylor College of Medicine, Houston, TX 77030 3411, USA
    Int J Dermatol 46:94-8. 2007
  54. ncbi A 4-month, open-label study evaluating the efficacy of eflornithine 11.5% cream in the treatment of unwanted facial hair in women using TrichoScan
    Rolf Hoffmann
    Dermaticum, Privatpraxis für Dermatologie, Kaiser Joseph Str 262, 79098 Freiburg, Germany
    Eur J Dermatol 18:65-70. 2008
    b>Eflornithine 11.5% cream is an effective treatment for unwanted facial hair (UFH) in women with the effect on facial hair growth starting to be seen from 1 month after treatment initiation...
  55. ncbi Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention
    F L Meyskens
    Department of Medicine, Chao Family Comprehensive Cancer Center, University of California, Irvine, USA
    J Natl Cancer Inst 90:1212-8. 1998
    ..In a follow-up study, we have attempted to determine the lowest dose of DFMO that can suppress the polyamine content of rectal mucosa over a course of 1 year with no or minimal side effects...
  56. pmc Validation of spermidine synthase as a drug target in African trypanosomes
    Martin C Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Biochem J 409:563-9. 2008
    ..brucei cannot scavenge sufficient spermidine from their environment to meet growth requirements...
  57. pmc Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content
    L M Shantz
    Department of Cellular and Molecular Physiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033
    Biochem J 288:511-8. 1992
    ..DFMO treatment did not interfere with the expression of plasmids driven by the RSV promoter. These results suggest that low spermidine levels interfere with the replication of plasmids containing the SV40 origin of replication...
  58. ncbi A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women
    Iltefat Hamzavi
    Department of Dermatology and Skin Science, University of British Columbia and the Vancouver Coastal Health Research Institute, British Columbia, Canada
    J Am Acad Dermatol 57:54-9. 2007
    ..This study was designed to determine whether topical eflornithine can enhance the efficacy of laser hair removal.
  59. ncbi Intersubunit location of the active site of mammalian ornithine decarboxylase as determined by hybridization of site-directed mutants
    K E Tobias
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Biochemistry 32:5842-7. 1993
    ....
  60. ncbi The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism
    Joseph Jackson
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, USA
    Int J Dermatol 46:976-81. 2007
    ..Women participating in two randomized clinical trials evaluated a new treatment (eflornithine 13.9% cream)...
  61. ncbi Inhibitors of polyamine metabolism: review article
    H M Wallace
    Department of Medicine, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, United Kingdom
    Amino Acids 26:353-65. 2004
    ....
  62. pmc Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series
    Francesco Checchi
    Epicentre, Paris, France
    PLoS Negl Trop Dis 1:e64. 2007
    ..sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest Uganda in 2002-2003, following on a previously reported terminated trial in nearby ..
  63. ncbi Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice
    S Gupta
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 60:5125-33. 2000
    ....
  64. pmc Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study
    Gerardo Priotto
    Epicentre, 75011 Paris, France
    BMJ 336:705-8. 2008
    To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis.
  65. ncbi Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola
    J Robays
    Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:265-71. 2008
    To compare the cost-effectiveness of eflornithine and melarsoprol in the treatment of human African trypanosomiasis.
  66. ncbi Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis
    Francois Chappuis
    Medecins Sans Frontieres, Geneva University Hospitals, Geneva, Switzerland
    Clin Infect Dis 41:748-51. 2005
    Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0...
  67. ncbi Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial
    Stacy R Smith
    Therapeutics, Inc, San Diego, California, USA
    Dermatol Surg 32:1237-43. 2006
    b>Eflornithine cream is approved for the reduction of unwanted facial hair in women...
  68. ncbi Eflornithine for the treatment of human African trypanosomiasis
    Christian Burri
    Swiss Tropical Institute, Swiss Center for International Health, Socinstrasse 57, P O Box, 4002 Basel, Switzerland
    Parasitol Res 90:S49-52. 2003
    b>Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases...
  69. ncbi Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis
    Bokelo Mpia
    Hôpital de Nioki, Nioki, Democratic Republic of Congo
    Trop Med Int Health 7:775-9. 2002
    To evaluate the efficacy and toxicity of a combination of eflornithine and melarsoprol among relapsing cases of Gambian trypanosomiasis.
  70. ncbi Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair
    B Malhotra
    Bristol-Myers Squibb, Princeton, New Jersey 08540, USA
    J Clin Pharmacol 41:972-8. 2001
    ..the results of an open-label, multiple-dose study to determine percutaneous absorption and pharmacokinetics of eflornithine following topical treatment with eflornithine HCl 13.9% cream (Vaniqa)...
  71. ncbi Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa), a novel treatment for excessive facial hair
    J G Hickman
    Education and Research Foundation Inc, 2602 Langhorne Road, VA 24501, USA
    Curr Med Res Opin 16:235-44. 2001
    b>Eflornithine HCl 13.9% cream (Vaniqa) is a novel treatment for the management of unwanted facial hair in women...
  72. ncbi Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells
    Lan Liu
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1056-67. 2003
    ....
  73. ncbi Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss
    Deric L Wheeler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53762, USA
    Cancer Res 63:3037-42. 2003
    ..Severe hair loss observed in PKC epsilon transgenic mice on DFMO during skin tumor promotion has not been reported before in the prevention of cancer in other animal models or in human cancer prevention trials...
  74. pmc Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
    Robert J Rounbehler
    Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    Cancer Res 69:547-53. 2009
    ..These findings suggest that agents, such as DFMO, that target the polyamine pathway may show efficacy in high-risk, MYCN-amplified neuroblastoma...
  75. ncbi The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness
    K Na-Bangchang
    Faculty of Allied Health Sciences, Thammasat University, Pathumtanee, Thailand
    Eur J Clin Pharmacol 60:269-78. 2004
    To investigate the plasma, cerebrospinal fluid (CSF) levels and pharmacokinetics of eflornithine (DFMO) in patients with late-stage T.b...
  76. pmc Multiple regulation of ornithine decarboxylase in enzyme-overproducing cells
    T Kameji
    Department of Nutrition, Jikei University School of Medicine, Tokyo, Japan
    Biochem J 289:581-6. 1993
    ....
  77. ncbi Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells
    Andrea Manni
    Department of Medicine, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    Clin Exp Metastasis 19:95-105. 2002
    ..Furthermore, the data suggest that PA involvement is distal to local invasion in the metastatic cascade...
  78. ncbi Phosphatidylinositol 3-kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth
    F Flamigni
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Italy
    Biochem Biophys Res Commun 239:729-33. 1997
    ....
  79. ncbi Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity
    Gad M Gilad
    Research and Development, Laboratory for Neuroscience, Assaf Harofeh Medical Center, Zrifin, Israel
    Brain Res 943:23-9. 2002
    ..9% NaCl). A 14-day course of alpha-difluoromethylornithine treatment resulted in a complete putrescine depletion and over 50% reduction in polyamines, and led to changes in open field activity indicative of altered emotional behavior...
  80. ncbi Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer
    Janine G Einspahr
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 8:149-55. 2002
    ....
  81. ncbi Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells
    Gail L Matters
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, H171, Hershey, PA 17033 0850, USA
    Clin Exp Metastasis 22:331-9. 2005
    ..The decrease in meprin alpha expression in DFMO and SAM486A-treated cells indicates a means by which these compounds can decrease the invasiveness of metastatic breast cancer cells...
  82. ncbi Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice
    Carlos Lopez-Garcia
    Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 149:5012-23. 2008
    ..In conclusion, our results indicate that ODC inhibition at d 8 of pregnancy is related to alterations in yolk sac formation and trophoblast differentiation, affecting processes such as vasculogenesis and steroidogenesis...
  83. ncbi Polyamines protect against radiation-induced oxidative stress
    Albert W von Deutsch
    Space Medicine and Life Sciences Research Center, USA
    Gravit Space Biol Bull 18:109-10. 2005
    ..The purpose of this study was to study the role of the polyamine pathway in attenuating free radical-induced damage...
  84. ncbi Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips
    Meral Unal
    Department of Biology, Arts and Sciences Faculty, Marmara University, Goztepe 81040, Istanbul, Turkey
    Acta Biol Hung 59:93-102. 2008
    ....
  85. ncbi Induction of apoptotic cell death by putrescine
    Koichi Takao
    Department of Experimental Medical Science, Lund University, S 22184 Lund, Sweden
    Int J Biochem Cell Biol 38:621-8. 2006
    ..In conclusion, deregulation of polyamine homeostasis may negatively affect cell proliferation and eventually lead to cell death by apoptosis if putrescine levels become too high...
  86. ncbi Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes
    Ildikó Loikkanen
    Department of Biochemistry, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Differentiation 73:303-12. 2005
    ..We propose that ODC and polyamines have an important role in kidney organogenesis, being involved in the regulation of the expression of genes implicated in epithelial-mesenchymal tissue interactions...
  87. ncbi Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma
    Yan Chen
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Int J Cancer 118:2344-9. 2006
    ..Thus, targeting both polyamine biosynthesis and polyamine transport from the tumor microenvironment enhances the efficacy of polyamine-based therapy in this mouse model of SCC...
  88. ncbi Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes
    Ivana Stanic
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 216:153-61. 2008
    ..Moreover, these results indicate that a reduction of polyamine levels not only leads to inhibition of cell proliferation, but also of caspase-mediated pathways of chondrocyte apoptosis...
  89. ncbi APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse
    S H Erdman
    Department of Radiation Oncology, Arizona Cancer Center and Steele Memorial Children s Research Center, The University of Arizona, Tucson, AZ 5724, USA
    Carcinogenesis 20:1709-13. 1999
    ..In the FAP population, DFMO may be of value in the chemoprevention of small intestinal adenocarcinoma that remains a risk following colectomy...
  90. ncbi Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines
    Christophe Moinard
    Laboratoire de Biochimie, Biologie Moléculaire et Nutrition EA 2416 and Centre de Recherche en Nutrition Humaine, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    Clin Sci (Lond) 102:287-95. 2002
    ..These data suggest that OKG (or its metabolites) and arginine are channelled differently in PMNs. This hypothesis deserves further study...
  91. ncbi Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent
    F Raul
    INSERM U682, University Louis Pasteur EA 3430, Laboratory of Nutritional Cancer Prevention, IRCAD, 1 Place de l Hopital, 67091 Strasbourg Cedex, France
    Biochem Soc Trans 35:353-5. 2007
    ....
  92. ncbi Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms
    R M Ray
    Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Gastrointest Liver Physiol 281:G37-43. 2001
    ..Growth arrest in the p53-mutated Caco-2 line after polyamine depletion occurs by a different, yet unknown, mechanism...
  93. ncbi Spermidine is essential for normal proliferation of trypanosomatid protozoa
    N S Gonzalez
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and CONICET, A Machado 151, 1405, Buenos Aires, Argentina
    FEBS Lett 508:323-6. 2001
    ..In all cases the reinitiation of proliferation occurred only after the addition of exogenous spermidine, and neither putrescine nor spermine were able to induce the same effect...
  94. ncbi p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion
    Ai Hong Zhang
    Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 293:C379-89. 2007
    ..These results indicate that NDRG1 is one of the direct mediators of induced p53 following polyamine depletion and that p53-dependent NDRG1 expression plays a critical role in the negative control of IEC proliferation...
  95. ncbi Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells
    Shiho Kaneko
    Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
    Am J Physiol Cell Physiol 293:C729-37. 2007
    ..These results suggest that spermine plays an important role in stimulation of mRNA expression of CAT-1, which is a crucial role in ornithine cytotoxicity in OAT-deficient hTERT-RPE cells...
  96. ncbi Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells
    F Flamigni
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Amino Acids 33:197-202. 2007
    ....
  97. ncbi Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels
    Carmen M Bastida
    Department of Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Am J Physiol Endocrinol Metab 292:E1010-7. 2007
    ..All of these data suggest a relevant role for testosterone, ODC, and polyamines in the mouse adrenal function...
  98. ncbi The effect of DFMO induced uptake of [3H] putrescine on human glioma cells
    E S Redgate
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA
    J Neurooncol 55:71-80. 2001
    ..These results support the concept that treatment with the combination of polyamine inhibitors and radioactive polyamines might be a useful adjunct to current therapies for glioblastoma multiforme...
  99. ncbi Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors
    Laura R Saunders
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Mol Cancer Ther 5:2777-85. 2006
    ..These findings warrant clinical evaluation of tumor samples to determine if high ODC activity levels predict sensitivity to HDAC inhibitors...
  100. ncbi Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox
    Francois Gaboriau
    INSERM, U522, Hopital Pontchaillou, F 35033, Rennes Cedex, France
    Biometals 19:623-32. 2006
    ..Altogether, our data provide insights that, in the three rat liver cell culture models, the cytostatic effect of the iron chelator O-trensox may be the addition of two mechanisms: iron and polyamine depletion...
  101. ncbi The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase
    Baiqing Tang
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochem Pharmacol 72:806-15. 2006
    ..Our results show that MTOB-induced growth inhibition and apoptosis is not simply secondary due to ODC inhibition and implies that MTOB activates apoptosis via other mechanisms...

Research Grants54

  1. APOPTOSIS IN COLON CANCER CHEMOPREVENTION
    Eugene Gerner; Fiscal Year: 2005
    ..abstract_text> ..
  2. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2012
    ..Few drugs are available, the best of which (eflornithine) is costly and requires a prolonged regimen, and the worst (melarsoprol) kills up to 10% of recipients...
  3. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..Only a handful of drugs are in use for treating HAT, the best of which (eflornithine) is expensive and requires a difficult regimen, the worst of which (melarsoprol) kills up to 10% of recipients...
  4. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..Only a handful of drugs are in use for treatment, the best of which (eflornithine) is expensive and requires a difficult regimen, the worst of which (melarsoprol) kills up to 10% of recipients...
  5. POLYAMINE METABOLISM AND AIDS ASSOCIATED PNEUMONIA
    ALLEN CLARKSON JR; Fiscal Year: 1992
    ..success has been met in clinical trials using an anti- polyamine agent, DL-alpha-difluoromethylornithine (DFMP, eflornithine), to treat PCP in those AIDS patients refractory or intolerant to the standard treatment protocols - ..
  6. POLYAMINE INVOLVEMENT IN MAMMARY CARCINOGENESIS
    Andrea Manni; Fiscal Year: 2001
    ....
  7. Polyamines and Breast Cancer Biology
    Andrea Manni; Fiscal Year: 2005
    ..The ultimate goal of these studies is to identify critical signaling molecules which can be targeted in conjunction with antipolyamine therapy to optimize prevention of metastasis from breast cancer. ..
  8. PanAmerican Society for Pigment Cell Research (PASPCR)
    Frank Meyskens; Fiscal Year: 2004
    ..abstract_text> ..
  9. Chemoprevention of Oral Cancer with BBIC
    Frank Meyskens; Fiscal Year: 2007
    ..abstract_text> ..
  10. Phase III Colon Cancer Prevention Trial
    Frank Meyskens; Fiscal Year: 2006
    ..The overall goal of our work is to develop safe combinations of chemoprevention agents that can be used in the practice setting and complement current surveillance efforts. ..
  11. Gordon Research Conference of Polyamine
    Eugene Gerner; Fiscal Year: 2005
    ..abstract_text> ..
  12. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  14. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  15. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  16. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  17. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  18. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  19. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  20. Assessing Deployment of Microbicidal Gels With Label-Free Optical Measurement
    Adam Wax; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. Cell-specific Transcript Profiling in Complex Tissues
    David Morris; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Apoptotic mechanisms in NSAID chemoprevention
    STEVEN DAMBROSIO; Fiscal Year: 2008
    ..abstract_text> ..
  23. ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATION
    ERIC M VERDIN; Fiscal Year: 2010
    ..These experiments have the potential of identifying novel factors mediating HIV transcriptional regulation that could be targeted therapeutically in the future. ..
  24. Coherence Imaging for Assessing Colorectal Neoplasia
    Adam Wax; Fiscal Year: 2010
    ..abstract_text> ..
  25. NABTC CENTRAL OPERATION GRANT (UCSF PROJECT LEADER)
    Michael Prados; Fiscal Year: 2008
    ..The NABTC will treat patients using novel therapeutic agents with the ultimate goal to increase quality, and hopefully, overall survival in this patient population. ..
  26. In vivo detection of pre-cancerous lesions using a/LCL
    Adam Wax; Fiscal Year: 2008
    ..abstract_text> ..
  27. Clinical Trial of Selenium and Prostate Biomarkers
    James Marshall; Fiscal Year: 2010
    ..This study will provide key in vivo, human data on the mechanisms of selenium's action in the prostate, and greatly help interpret the results of the important chemoprevention trials such as HGPIN and SELECT. ..
  28. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
    ....
  29. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  30. Selenium Based Chemoprevention - HGPIN
    James Marshall; Fiscal Year: 2008
    ..This study promises to be the largest and most methodologically rigorous to date of HGPIN, which is widely believed to be the key premalignant lesion for prostate cancer. ..
  31. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2008
    ..abstract_text> ..
  32. Assessing nuclear morphology in thick tissues using fLCI
    Adam Wax; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Modulation of Diabetic Kidney Growth/ Hypertrophy
    Joseph Satriano; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. Defective PS Exposure in Neutrophil Apoptosis in CGD
    Donna Bratton; Fiscal Year: 2007
    ..It is expected that data from this investigation will identify novel potential therapeutic targets to address disordered inflammation of CGD. ..
  35. NUTRITIONAL PREVENTION OF CANCER
    James Marshall; Fiscal Year: 2003
    ..The proposed project will complete the data collection for the NPC trial and will utilize this invaluable resource to verify the effects of selenium supplementation through a series of publications. ..
  36. PEDIATRIC BRAIN TUMOR CLINICAL TRIAL CONSORTIUM
    Michael Prados; Fiscal Year: 2003
    ..The aim of these treatment approaches is to increase disease-free and overall survival in children with brain tumors. ..
  37. TRANSLATIONAL CONTROL OF ONCOPROTEIN MDM2 SYNTHESIS
    David Morris; Fiscal Year: 2003
    ..The sequences in the S-mdm2 mRNA that are responsible for the differences in its translation between normal and tumor cells will also be defined. ..
  38. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  39. DEVELOPMENT OF TRANSLATION STATE ARRAY ANALYSIS
    David Morris; Fiscal Year: 2003
    ..This study will provide more finely honed high-throughput tools to provide insight into both mechanisms of regulation of individual genes and the levels and activities of the proteins that ultimately dictate phenotype. ..
  40. Agmatine Mediated Arrest of Proliferation
    Joseph Satriano; Fiscal Year: 2003
    ..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
  41. MODULATION OF CD8 T CELL FUNCTION BY HIV ENVELOPE PROTEI
    Eric Verdin; Fiscal Year: 2003
    ..abstract_text> ..
  42. GROWTH REGULATION OF POLYAMINE SYNTHESIS
    David Morris; Fiscal Year: 2001
    ..These studies will not only define the mechanism of regulation of a key step in polyamine biosynthesis, but will also extend our fundamental knowledge of the role uORFs in translational control generally. ..
  43. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004
    ..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..
  44. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
    ..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
  45. A New In Vitro Model for HIV Latency
    Eric Verdin; Fiscal Year: 2004
    ..These studies should further establish the validity of our model for the study of HIV latency in patients. ..
  46. Regulation of HIV transcription and replication by SDF-1gamma
    Eric Verdin; Fiscal Year: 2006
    ..We will determine whether a correlations exist between SDF-1gamma expression, HIV replication and the presence of the SDF1-3'A allele. ..
  47. Tool to Define the Antiproliferative Effects of Agmatine
    Joseph Satriano; Fiscal Year: 2006
    ..These pathways will have particular application to diabetes and IRI in kidney, models we plan to pursue. [unreadable] [unreadable]..
  48. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  49. Chemoprevention of Skin Cancer - DFMO Phase III Trial
    Howard Bailey; Fiscal Year: 2005
    ..Ototoxicity and gastrointestinal toxicity have been most common). The objectives, which are unchanged from our original proposal, are all on schedule to be completed in the next 1-2 years. ..
  50. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..
  51. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  52. DFMO Prevention Study (2b) in Organ Transplant Subjects
    Howard Bailey; Fiscal Year: 2005
    ..abstract_text> ..
  53. MOLECULAR CHEMOPREVENTION MECHANISMS OF TEA POLYPHENOLS
    Steven Stratton; Fiscal Year: 2005
    ....
  54. MODULATION OF T CELL FUNCTIONS BY HIV1 TAT
    Eric Verdin; Fiscal Year: 2001
    ..These studies will further define the role of Tat as modulator of T cell differentiated functions and establish its role in HIV pathogenesis. ..