secretin

Summary

Summary: A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)

Top Publications

  1. ncbi An endoscopic pancreatic function test with synthetic porcine secretin for the evaluation of chronic abdominal pain and suspected chronic pancreatitis
    Darwin L Conwell
    The Pancreas Clinic, Department of Gastroenterology, Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastrointest Endosc 57:37-40. 2003
  2. pmc Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    J Mol Neurosci 36:279-85. 2008
  3. ncbi Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Biol Chem 282:30363-72. 2007
  4. pmc Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
    Konstantin V Korotkov
    Department of Biochemistry, Biomolecular Structure Center, University of Washington, Seattle, WA 98195, USA
    Structure 17:255-65. 2009
  5. pmc YghG (GspSβ) is a novel pilot protein required for localization of the GspSβ type II secretion system secretin of enterotoxigenic Escherichia coli
    Timothy G Strozen
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Infect Immun 80:2608-22. 2012
  6. ncbi The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development
    Harriet A Watkins
    School of Biological Sciences, University of Auckland, New Zealand
    Drug Discov Today 17:1006-14. 2012
  7. pmc Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation
    Shannon Glaser
    Scott and White Digestive Disease Research Center, College of Medicine, Temple, TX, USA
    Hepatology 52:204-14. 2010
  8. pmc Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts
    Mitsuro Kanda
    Johns Hopkins Medical Institutions, Department of Pathology, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gut 62:1024-33. 2013
  9. ncbi Focus on the splicing of secretin GPCRs transmembrane-domain 7
    Danijela Markovic
    GPCR Pathophysiology Group, Division of Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Trends Biochem Sci 34:443-52. 2009
  10. ncbi Structure of a widely conserved type IV pilus biogenesis factor that affects the stability of secretin multimers
    Melissa B Trindade
    Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, 41 rue Jules Horowitz, F 38027 Grenoble, France
    J Mol Biol 378:1031-9. 2008

Detail Information

Publications301 found, 100 shown here

  1. ncbi An endoscopic pancreatic function test with synthetic porcine secretin for the evaluation of chronic abdominal pain and suspected chronic pancreatitis
    Darwin L Conwell
    The Pancreas Clinic, Department of Gastroenterology, Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastrointest Endosc 57:37-40. 2003
    ..Synthetic porcine secretin, a 27 amino acid peptide identical to the biologic form, is available for exocrine function testing...
  2. pmc Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    J Mol Neurosci 36:279-85. 2008
    ..this paper, we have systematically evaluated GPCRs that are capable of association with the prototypic Family B secretin receptor. All of the receptor constructs were shown to traffic normally to the plasma membrane...
  3. ncbi Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor
    Kaleeckal G Harikumar
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Biol Chem 282:30363-72. 2007
    Oligomerization of the Class II G protein-coupled secretin receptor has been reported, but the molecular basis for this and its functional significance have not been determined...
  4. pmc Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
    Konstantin V Korotkov
    Department of Biochemistry, Biomolecular Structure Center, University of Washington, Seattle, WA 98195, USA
    Structure 17:255-65. 2009
    ..structure of the periplasmic N-terminal domain of GspD (peri-GspD) from the type 2 secretion system (T2SS) secretin in complex with a nanobody, the VHH domain of a heavy-chain camelid antibody...
  5. pmc YghG (GspSβ) is a novel pilot protein required for localization of the GspSβ type II secretion system secretin of enterotoxigenic Escherichia coli
    Timothy G Strozen
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Infect Immun 80:2608-22. 2012
    ..pppA, and yghG) in the atypical T2SS(β) operon revealed that YghJ is not required for assembly of the GspD(β) secretin or secretion of LT, that PppA is likely the prepilin peptidase required for the function of T2SS(β), and that ..
  6. ncbi The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development
    Harriet A Watkins
    School of Biological Sciences, University of Auckland, New Zealand
    Drug Discov Today 17:1006-14. 2012
    The secretin family G protein-coupled receptors, characterized by a large N-terminal extracellular domain and seven transmembrane helices, are drug targets in many diseases, including migraine, cardiovascular disease, diabetes, ..
  7. pmc Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation
    Shannon Glaser
    Scott and White Digestive Disease Research Center, College of Medicine, Temple, TX, USA
    Hepatology 52:204-14. 2010
    ..cAMP)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and is closely associated with increased secretin receptor (SR) expression...
  8. pmc Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts
    Mitsuro Kanda
    Johns Hopkins Medical Institutions, Department of Pathology, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, 1550 Orleans Street, Baltimore, MD 21231, USA
    Gut 62:1024-33. 2013
    ..Better approaches are needed to characterise these lesions. In this study we evaluated the utility of detecting mutant DNA in secretin-stimulated pancreatic juice.
  9. ncbi Focus on the splicing of secretin GPCRs transmembrane-domain 7
    Danijela Markovic
    GPCR Pathophysiology Group, Division of Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Trends Biochem Sci 34:443-52. 2009
    ..Intriguingly, this mechanism appears to extensively target the Secretin family of GPCRs, especially the exon that encodes a 14 amino acid sequence that forms the distal part of 7th ..
  10. ncbi Structure of a widely conserved type IV pilus biogenesis factor that affects the stability of secretin multimers
    Melissa B Trindade
    Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, 41 rue Jules Horowitz, F 38027 Grenoble, France
    J Mol Biol 378:1031-9. 2008
    ..This includes the conserved outer membrane-localized secretin, which forms a pore through which Tfp emerge on the bacterial surface...
  11. ncbi Severe chronic pancreatitis versus suspected pancreatic disease: dynamic MR cholangiopancreatography after secretin stimulation
    R Manfredi
    Department of Radiology, A Gemelli University Hospital, Rome, Italy
    Radiology 214:849-55. 2000
    To assess whether secretin stimulation improves visualization of the pancreatic ducts at magnetic resonance (MR) cholangiopancreatography (MRCP) in patients with severe chronic pancreatitis or suspected pancreatic disease.
  12. ncbi EUS and K-ras analysis of pure pancreatic juice collected via a duodenoscope after secretin stimulation for diagnosis of pancreatic mass lesion: a prospective study
    T Okai
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Gastrointest Endosc 50:797-803. 1999
    ..This prospective study assessed the utility of a combination of endoscopic ultrasound (EUS) and genetic analysis of pure pancreatic juice in the diagnosis of pancreatic mass lesions...
  13. pmc Assembly of the type II secretion system: identification of ExeA residues critical for peptidoglycan binding and secretin multimerization
    Gang Li
    Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
    J Bacteriol 193:197-204. 2011
    ..Assembly of the secretion channel ExeD secretin into the outer membrane is dependent on the peptidoglycan binding domain of ExeA...
  14. ncbi ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily
    T Nechiporuk
    Department of Human Genetics, Division of Cardiology, University of Utah, Eccles Institute of Human Genetics, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:4150-7. 2001
    ..ETL belongs to the secretin family of G-protein-coupled peptide hormone receptors and the EGF-TM7 subfamily of receptors...
  15. pmc Secretins: dynamic channels for protein transport across membranes
    Konstantin V Korotkov
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    Trends Biochem Sci 36:433-43. 2011
    ..b>Secretin subunits contain multiple domains, which interact with numerous other proteins, including pilotins, secretion-..
  16. ncbi Multiple actions of secretin in the human body
    Ian P Y Lam
    Department of Zoology, University of Hong Kong, Hong Kong, China
    Int Rev Cytol 265:159-90. 2008
    The discovery of secretin initiated the field of endocrinology...
  17. ncbi Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development
    Julia K Archbold
    School of Biological Sciences, University of Auckland, New Zealand
    Trends Pharmacol Sci 32:591-600. 2011
    b>Secretin family G protein-coupled receptors (GPCRs) are important therapeutic targets for migraine, diabetes, bone disorders, inflammatory disorders and cardiovascular disease...
  18. pmc Structural and functional insights into the pilotin-secretin complex of the type II secretion system
    Shuang Gu
    Queen Mary University of London, School of Biological and Chemical Sciences, London, England
    PLoS Pathog 8:e1002531. 2012
    ..Usually, a cognate lipoprotein pilot is essential for the assembly of the secretin in the outer membrane. The structures of the pilotins of the T3SS and T4PS have been described...
  19. ncbi Administration of secretin for autism alters dopamine metabolism in the central nervous system
    Yoshihiro Toda
    Department of Pediatrics, School of Medicine, University of Tokushima, 3 18 15, Kuramoto Cho, Tokushima shi, Tokushima 770 8503, Japan
    Brain Dev 28:99-103. 2006
    We evaluated the clinical effects of intravenously administered secretin in 12 children with autism (age range: 4-6 years, median age: 9 years, boy:girl=8:4)...
  20. ncbi Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication
    Jong Ik Hwang
    Graduate School of Medicine, Korea University, Seoul, Republic of Korea
    Mol Biol Evol 30:1119-30. 2013
    In humans, the secretin-like G protein-coupled receptor (GPCR) family comprises 15 members with 18 corresponding peptide ligand genes...
  21. ncbi Endogenous release of secretin from the hypothalamus
    J Y S Chu
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, PRC
    Ann N Y Acad Sci 1070:196-200. 2006
    Previous studies demonstrated that secretin could be released from the cerebellum, where it exerts a facilitatory action on the GABAergic inputs into the Purkinje neurons...
  22. ncbi The arrangement of the transmembrane helices in the secretin receptor family of G-protein-coupled receptors
    D Donnelly
    Department of Pharmacology, University of Leeds, UK
    FEBS Lett 409:431-6. 1997
    The members of the secretin receptor family of G-protein-coupled receptors share no significant sequence similarity to the more familiar rhodopsin-like family...
  23. ncbi Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma
    Wei Qun Ding
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Res 62:5223-9. 2002
    b>Secretin receptors that are key for regulation of healthy pancreatic ductal epithelial cells have been reported to be functionally absent on ductal pancreatic adenocarcinomas...
  24. pmc A systematic review of secretin for children with autism spectrum disorders
    Shanthi Krishnaswami
    2525 West End Ave, Suite 600, 6th Floor, Nashville, TN 37203 1738, USA
    Pediatrics 127:e1322-5. 2011
    As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Secretin is 1 of many medical treatments studied for treating the symptoms of ASDs, but there is currently no consensus regarding which ..
  25. ncbi Secretin as a neuropeptide
    Samuel S M Ng
    Department of Zoology, University of Hong Kong, Hong Kong, PRC
    Mol Neurobiol 26:97-107. 2002
    The role of secretin as a classical hormone in the gastrointestinal system is well-established...
  26. ncbi Regulation of cholangiocyte bicarbonate secretion
    N Kanno
    Department of Internal Medicine, Scott and White Hospital and Texas A and M University System Health Science Center, College of Medicine, TX 76504, USA
    Am J Physiol Gastrointest Liver Physiol 281:G612-25. 2001
    The objective of this review article is to discuss the role of secretin and its receptor in the regulation of the secretory activity of intrahepatic bile duct epithelial cells (i.e., cholangiocytes)...
  27. ncbi Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:2894-903. 2004
    Distinct spatial approximations between residues within the secretin pharmacophore and its receptor can provide important constraints for modeling this agonist-receptor complex...
  28. pmc Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease
    Jesus M Banales
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Pathol 173:1637-46. 2008
    ..We show here that under basal conditions and in response to secretin and hypotonicity, cysts from PCK rats expanded to a greater degree than cysts formed by normal bile ducts...
  29. pmc Molecular cloning and expression of a cDNA encoding the secretin receptor
    T Ishihara
    Osaka Bioscience Institute, Japan
    EMBO J 10:1635-41. 1991
    b>Secretin is a 27 amino acid peptide which stimulates the secretion of bicarbonate, enzymes and potassium ion from the pancreas...
  30. ncbi Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Sciences Center, College of Medicine, Temple, TX, USA
    Hepatology 41:1037-45. 2005
    ..We tested in isolated cholangiocytes if secretin enhances ASBT translocation to the apical membrane from latent preexisting intracellular stores...
  31. ncbi The Secretin GPCRs descended from the family of Adhesion GPCRs
    Karl J V Nordström
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 26:71-84. 2009
    ..Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and Methuselah families of GPCRs with a focus on nine genomes...
  32. ncbi Secretin-stimulated amylase release into blood is impaired in type 1 diabetes mellitus
    A Swislocki
    Section of Endocrinology, Medical Service, Veterans Affairs Medical Center, Martinez, California 94553, USA
    Horm Metab Res 37:326-30. 2005
    ....
  33. ncbi Polar assembly of the type IV pilus secretin in Myxococcus xanthus
    Eric Nudleman
    Department of Developmental Biology, Stanford University School of Medicine, B300 Beckman Center, 279 Campus Drive, Stanford, CA 94305, USA
    Mol Microbiol 60:16-29. 2006
    The type IV pilus filament of Myxococcus xanthus penetrates the outer membrane through a gated channel--the PilQ secretin. Assembly of the channel and formation of PilQ multimeric complexes that resist disassembly in heated detergent is ..
  34. pmc AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin
    Carrie Lynn Keiski
    Molecular Structure and Function, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Structure 18:265-73. 2010
    ..that AlgK plays a role in the assembly of the alginate biosynthetic complex and represents the periplasmic component of a new type of outer membrane secretin that differs from canonical bacterial capsular polysaccharide secretion systems.
  35. pmc Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor
    Fan Gao
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mol Pharmacol 76:264-74. 2009
    ..Here, we demonstrate that the agonist occupied wild-type secretin receptor is predominantly in a guanine nucleotide-sensitive high-affinity state and exhibits negative ..
  36. pmc Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile
    Noritaka Minagawa
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Gastroenterology 133:1592-602. 2007
    ..We examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R) in mediating bicarbonate secretion because this is the only intracellular Ca(2+) release channel in cholangiocytes...
  37. pmc Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system
    Carrie Yuen Yee Cheng
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neuropsychopharmacology 36:459-71. 2011
    b>Secretin (Sct) is released into the circulation postprandially from the duodenal S-cells...
  38. ncbi Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors
    C D Ulrich
    Center for Basic Research in Digestive Diseases, Department of Molecular Biology Biochemistry, Mayo Medical School, Rochester, Minnesota 55905, USA
    Gastroenterology 114:382-97. 1998
  39. pmc Secretin as a neurohypophysial factor regulating body water homeostasis
    Jessica Y S Chu
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 106:15961-6. 2009
    ..Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo-..
  40. ncbi Newly-identified receptors for peptide histidine-isoleucine and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily
    Sheng Wu
    Department of Biology, University of Victoria, Victoria BC, Canada
    J Mol Endocrinol 41:343-66. 2008
    A group of ten hormones in humans are structurally related and known as the secretin superfamily. These hormones bind to G-protein-coupled receptors that activate the cAMP pathway and are clustered as the secretin or B family...
  41. ncbi Quantification of pancreatic exocrine function with secretin-enhanced magnetic resonance cholangiopancreatography: normal values and short-term effects of pancreatic duct drainage procedures in chronic pancreatitis. Initial results
    M A Bali
    Department of Radiology, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik, 808, 1070, Brussels, Belgium
    Eur Radiol 15:2110-21. 2005
    ..patients with chronic pancreatitis (CP) before and after pancreatic duct drainage procedures (PDDP) with dynamic secretin-enhanced magnetic resonance (MR) cholangiopancreatography (S-MRCP)...
  42. pmc Physical, functional and conditional interactions between ArcAB and phage shock proteins upon secretin-induced stress in Escherichia coli
    Goran Jovanovic
    Division of Biology, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London, UK
    Mol Microbiol 74:16-28. 2009
    ..In addition we demonstrate that the pIV-dependent induction of psp expression in anaerobiosis is independent of PspBC, establishing that PspA and PspF can function as a minimal Psp system responsive to inner membrane stress...
  43. pmc The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:322-7. 1998
    ..the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. The hypocretin (Hcrt) protein products are restricted to neuronal cell bodies of the dorsal and lateral ..
  44. ncbi Pancreatic duct after pancreatoduodenectomy: morphologic and functional evaluation with secretin-stimulated MR pancreatography
    Josep Monill
    Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, Barcelona 08025, Spain
    AJR Am J Roentgenol 183:1267-74. 2004
    The purpose of this study was to evaluate the usefulness of secretin-enhanced MR pancreatography in evaluating morphologic changes and pancreatic function after pancreatoduodenectomy.
  45. pmc Diagnosis of mild chronic pancreatitis (Cambridge classification): comparative study using secretin injection-magnetic resonance cholangiopancreatography and endoscopic retrograde pancreatography
    Jin Kan Sai
    Department of Gastroenterology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    World J Gastroenterol 14:1218-21. 2008
    To investigate the usefulness of secretin injection-MRCP for the diagnosis of mild chronic pancreatitis.
  46. ncbi Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent
    H Yang
    CURE, Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 128:131-41. 2004
    I.v. injection of secretin activates neurons in brain areas controlling autonomic function and emotion...
  47. ncbi Efficacy of porcine secretin in children with autism and pervasive developmental disorder
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9101, USA
    J Autism Dev Disord 32:153-60. 2002
    b>Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea...
  48. ncbi Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain
    Joyce Tay
    Repligen Corporation, 41 Seyon Street, Waltham, MA 02453, USA
    Neurosci Lett 366:176-81. 2004
    In the present study expression levels of secretin and secretin receptor mRNAs in several brain regions of rats ranging in age from postnatal days 7 to 60 were investigated by quantitative real-time PCR...
  49. ncbi Circulating secretin activates supraoptic nucleus oxytocin and vasopressin neurons via noradrenergic pathways in the rat
    Sathya Velmurugan
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, United Kingdom
    Endocrinology 151:2681-8. 2010
    b>Secretin is a 27-amino acid brain-gut peptide from duodenal S-cells...
  50. ncbi Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement
    M Fatih Akisik
    Department of Radiology, Indiana University School of Medicine, 550 N University Blvd, Indianapolis, IN 46202, USA
    Radiology 250:103-9. 2009
    To retrospectively measure and compare changes in pancreatic apparent diffusion coefficient (ADC) following secretin administration in patients with and those without chronic pancreatitis (CP) who underwent magnetic resonance (MR) ..
  51. ncbi In vitro autoradiographic localization of (125)i-secretin receptor binding sites in rat brain
    Satoshi Nozaki
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 292:133-7. 2002
    Although the existence of the receptor for secretin in the brain was suggested, the localization of secretin receptor and the neuronal function of secretin have not been clarified yet...
  52. pmc Insignificant effect of secretin in rodent models of polycystic kidney and liver disease
    Xiaofang Wang
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 303:F1089-98. 2012
    ..Clinical trials of drugs that reduce cyclic AMP levels in target tissues are now in progress. Secretin may contribute to adenylyl cyclase-dependent urinary concentration and is a major agonist of adenylyl cyclase in ..
  53. pmc Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, USA
    FASEB J 26:5092-105. 2012
    ..cysteine trapping to systematically explore spatial approximations among residues in the first five positions of secretin and in every position within the receptor extracellular loops (ECLs)...
  54. ncbi Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD
    Martin Krehenbrink
    Institut Pasteur, Unité de Génétique Moléculaire, CNRS URA2172, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Biol 383:1058-68. 2008
    ..protein Sac7d was previously modified to bind with high affinity to the N domain of the outer membrane secretin PulD from the bacterium Klebsiella oxytoca...
  55. ncbi Ion transport in human pancreatic duct epithelium, Capan-1 cells, is regulated by secretin, VIP, acetylcholine, and purinergic receptors
    Jing Wang
    Department of Biology, University of Copenhagen, Denmark
    Pancreas 42:452-60. 2013
    ..Further, we aimed to determine functional expression of several receptors, in particular, purinergic receptors, and determine their effects on ion transport...
  56. ncbi Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients
    Isabel Pascual
    Department of Gastroenterology, University Clinic Hospital of Valencia, University of Valencia, Avda Blasco Ibanez 17, Valencia, 46010, Spain
    Dig Dis Sci 53:3234-41. 2008
    ..was to evaluate the pancreatographic findings and dynamics of pancreatic duct diameter, as determined by secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP), in patients with acute alcoholic pancreatitis or ..
  57. ncbi Immunohistochemical localizations of secretin, cholecystokinin, and somatostatin in the rat small intestine after acute cisplatin treatment
    Yohei Miyamoto
    Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc, Kamakura, Kanagawa 248 8555, Japan
    Exp Mol Pathol 77:238-45. 2004
    ..The immunohistochemical detection was performed using anti-secretin, anti-cholecystokinin (CCK), and anti-somatostatin with the avidin-biotin-immuno-peroxidase procedure...
  58. ncbi Pancreatic duct: morphologic evaluation with MR cholangiopancreatography after secretin stimulation
    Yoshihiko Fukukura
    Department of Radiology, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima shi 890 8520, Japan
    Radiology 222:674-80. 2002
    To evaluate the pancreatic duct after administration of secretin.
  59. ncbi Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor
    Paolo Onori
    Experimental Medicine, University of L Aquila, L Aquila, Italy
    Int J Cancer 127:43-54. 2010
    b>Secretin plays a key role in the regulation of normal cholangiocyte physiology via secretin receptor (SCTR)...
  60. ncbi Secretin: a pleiotrophic hormone
    J Y S Chu
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, PRC
    Ann N Y Acad Sci 1070:27-50. 2006
    b>Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone...
  61. pmc The serendipitous origin of chordate secretin peptide family members
    João C R Cardoso
    Centre of Marine Sciences, Universidade do Algarve, Faro, Portugal
    BMC Evol Biol 10:135. 2010
    The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications...
  62. ncbi A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor
    M A Shetzline
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:6756-62. 1998
    The secretin receptor is a member of a structurally distinct class of G protein-coupled receptors designated as Class II. The molecular mechanisms of secretin receptor signal termination are unknown...
  63. ncbi Secretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashion
    B K C Chow
    Department of Zoology, University of Hong Kong, Pokfulam, Hong Kong
    Biol Reprod 70:1594-9. 2004
    There is growing evidence that secretin, the first hormone discovered in our history, has functions in the brain other than in the gastrointestinal tract...
  64. ncbi The effectiveness of secretin in the management of autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Expert Opin Pharmacother 5:379-87. 2004
    ..After reports of improvements in autistic children who received secretin, this hormone became popular as a possible treatment for autism...
  65. ncbi Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element
    Leo Tsz On Lee
    Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong, People s Republic of China
    Mol Endocrinol 18:1740-55. 2004
    To unravel the mechanisms that regulate the human secretin gene expression, in this study, we have used secretin-expressing (HuTu-80 cells, human duodenal adenocarcinoma) and non-secretin-expressing [PANC-1 (human pancreatic ductile ..
  66. ncbi Secretin as a treatment for autism: a review of the evidence
    Barbara E Esch
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008 5439, USA
    J Autism Dev Disord 34:543-56. 2004
    b>Secretin is used in the United States for diagnosis of pancreatic gastrointestinal (GI) dysfunction and disease. Repeated therapeutic use has not been approved...
  67. ncbi Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials
    Peter Sturmey
    Department of Psychology, Queens College and The Graduate Center, The City University of New York, CUNY, Flushing, NY 112367, USA
    Res Dev Disabil 26:87-97. 2005
    ..Sokolski, K. N., Wachtel, R., Nabors, L., & Tildon, J. T. (1998). Improved social and language skills after secretin administration in patients with autism spectrum disorders...
  68. ncbi Effect of secretin on preadipocyte, differentiating and mature adipocyte functions
    P Miegueu
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada
    Int J Obes (Lond) 37:366-74. 2013
    Several gastrointestinal peptides are now recognized to have target functions beyond the intestinal wall, including effects on adipocytes. Secretin (SEC), one of the first identified, has not been evaluated in this context.
  69. ncbi Metabolic effects of secretin
    Revathi Sekar
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong
    Gen Comp Endocrinol 181:18-24. 2013
    b>Secretin (Sct), traditionally a gastrointestinal hormone backed by a century long research, is now beginning to be recognized also as a neuroactive peptide...
  70. ncbi Secretin, 100 years later
    William Y Chey
    Rochester Institute for Digestive Diseases and Sciences, 222 Alexander Street, Suite 3100, Rochester, NY 14607, USA
    J Gastroenterol 38:1025-35. 2003
    One hundred years have elapsed since the discovery of secretin by Bayliss and Starling in 1902...
  71. ncbi Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor
    Maoqing Dong
    Cancer Center and the Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 278:48300-12. 2003
    ..b>Secretin is a 27-residue peptide hormone with a diffuse pharmacophoric domain that binds to the secretin receptor, a ..
  72. ncbi Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA
    Mol Pharmacol 72:280-90. 2007
    ..In this work, we used two high-affinity, full-agonist, secretin-like photolabile probes having sites for covalent attachment in positions 21 and 23 and used sequential ..
  73. ncbi Secretin depolarizes nucleus tractus solitarius neurons through activation of a nonselective cationic conductance
    Bo Yang
    Dept of Physiology, Queen s Univ, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 286:R927-34. 2004
    The recent suggestion that secretin may be useful in treating autism and schizophrenia has begun to focus attention on the mechanisms underlying this gut-brain peptide's actions in the central nervous system (CNS)...
  74. ncbi Dynamic MR pancreatography after secretin administration: image quality and diagnostic accuracy
    Karin J Hellerhoff
    Department of Diagnostic Radiology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, D 81675 Munich, Germany
    AJR Am J Roentgenol 179:121-9. 2002
    The objective of our study was to assess the improvement of image quality and diagnostic accuracy of secretin-enhanced MR pancreatography compared with conventional MR pancreatography.
  75. ncbi Secretin: hypothalamic distribution and hypothesized neuroregulatory role in autism
    M G Welch
    Laboratory of Childhood Regulatory Disorders, Columbia University College of Physicians and Surgeons, Division of Neuroscience, NYSPI, 1051 Riverside Drive, New York, New York 10032, USA
    Cell Mol Neurobiol 24:219-41. 2004
    1. This study aims (1) to determine whether secretin is synthesized centrally, specifically by the HPA axis and (2) to discuss, on the basis of the findings in this and previous studies, secretin's possible neuroregulatory role in autism...
  76. pmc HxcQ liposecretin is self-piloted to the outer membrane by its N-terminal lipid anchor
    Véronique Viarre
    Laboratoire d Ingénierie des Systèmes Macromoléculaires UPR 9027, CNRS, Institut de Microbiologie de la Mediterranee, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 284:33815-23. 2009
    ..We found that HxcQ forms high molecular mass structures resistant to heat and SDS, revealing its secretin nature. Interestingly, we showed that HxcQ is a lipoprotein...
  77. ncbi Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin
    Manjula Mahata
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0838, USA
    Cell Tissue Res 345:87-102. 2011
    ..We tested whether secretin belonging to the glucagon/PACAP/VIP superfamily would increase transcription of the tyrosine hydroxylase (Th) ..
  78. ncbi A 1H-NMR study of the solution conformation of secretin. Resonance assignment and secondary structure
    A M Gronenborn
    FEBS Lett 215:88-94. 1987
    The solution conformation of the 27 residue polypeptide hormone secretin has been investigated by 1H-NMR spectroscopy under conditions where it adopts a fully ordered structure as judged by circular dichroism spectroscopy, namely in an ..
  79. pmc A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system
    Thomas Spreter
    Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, Canada
    Nat Struct Mol Biol 16:468-76. 2009
    ..The crystal structures of the periplasmic domain of the outer membrane secretin EscC and the inner membrane protein PrgH reveal the conservation of a modular fold among the three proteins that ..
  80. ncbi Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors
    M H Holtmann
    Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 270:14394-8. 1995
    b>Secretin and vasoactive intestinal polypeptide (VIP) receptors are closely related G protein-coupled receptors in a recently described family possessing a large amino-terminal ectodomain...
  81. pmc Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor
    Laurence J Miller
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA
    Br J Pharmacol 166:18-26. 2012
    The secretin receptor is a prototypic member of family B G protein-coupled receptors that binds and responds to a linear 27-residue peptide natural ligand...
  82. ncbi Molecular pharmacology of the secretin receptor
    Maoqing Dong
    Center for Basic Research in Digestive Diseases, Departments of Internal Medicine and Biochemistry Molecular Biology, Mayo Clinic and Foundation, Guggenheim 17, Mayo Clinic, Rochester, MN 55905, USA
    Receptors Channels 8:189-200. 2002
    The secretin receptor was the first member of the Class II family of G protein-coupled receptors to be cloned. It is prototypic of this family in its structure, function, and regulation...
  83. ncbi Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine
    G Rindi
    Department of Human Pathology, University of Pavia, Italy
    Development 126:4149-56. 1999
    ..The secretin-producing (S) cell is one of at least ten cell types belonging to the diffuse neuroendocrine system of the gut...
  84. ncbi Diagnostic role of secretin-enhanced MRCP in patients with unsuccessful ERCP
    Laszlo Czako
    First Department of Medicine, University of Szeged, Szeged, Hungary
    World J Gastroenterol 10:3034-8. 2004
    ..To evaluate the value of MR cholangiopancreatography (MRCP) in patients in whom endoscopic retrograde cholangiopancreatography (ERCP) was unsuccessfully performed by experts in a tertiary center...
  85. ncbi Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse
    William A Banks
    Geriatric Research, Education, and Clinical Center, St Louis University School of Medicine, 915 N Grand Boulevard, St Louis, MO 63106, USA
    J Pharmacol Exp Ther 302:1062-9. 2002
    b>Secretin is a gastrointestinal peptide belonging to the vasoactive intestinal peptide (VIP)/glucagon/pituitary adenylate cyclase-activating polypeptide (PACAP) family recently suggested to have therapeutic effects in autism...
  86. pmc A Single Amino Acid Substitution Changes the Self-Assembly Status of a Type IV Piliation Secretin
    Nicholas N Nickerson
    Institut Pasteur, Molecular Genetics Unit, Microbiology Department, Paris, France
    J Bacteriol 194:4951-8. 2012
    ....
  87. pmc Differential determinants for coupling of distinct G proteins with the class B secretin receptor
    Gene L Garcia
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, USA
    Am J Physiol Cell Physiol 302:C1202-12. 2012
    The secretin receptor is a prototypic class B G protein-coupled receptor that is activated by binding of its natural peptide ligand...
  88. pmc Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin
    Janice K V Tam
    School of Biological Sciences, Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 6:e19384. 2011
    At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear...
  89. pmc Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    Mol Pharmacol 74:413-22. 2008
    ..work, we have used photoaffinity labeling to identify a critical spatial approximation between residue five of secretin and a residue within the proposed third extracellular loop of the secretin receptor...
  90. ncbi Endogenous release and multiple actions of secretin in the rat cerebellum
    S M Y Lee
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neuroscience 134:377-86. 2005
    Previous studies demonstrated that secretin could modulate synaptic transmission in the rat cerebellum...
  91. ncbi Secretin and body fluid homeostasis
    Jessica Y S Chu
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Kidney Int 79:280-7. 2011
    ..From initial studies on the effects of secretin (SCT) on renal water reabsorption in the 1940s and recent investigations of its role in cardiovascular and ..
  92. ncbi Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1
    Leo T O Lee
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC
    Ann N Y Acad Sci 1070:393-8. 2006
    Previously, we found that secretin transcript levels were induced by all-trans retinoic acid (RA) in a neuroblastoma cell model, SH-SY5Y. In this article, this RA-dependent upregulation process was further investigated...
  93. pmc Cholangiocyte anion exchange and biliary bicarbonate excretion
    Jesus M Banales
    Laboratory of Molecular Genetics, Division of Gene Therapy and Hepatology, University of Navarra School of Medicine, Clinica Universitaria and CIMA, Avda Pio XII 55, E 31008 Pamplona, Spain
    World J Gastroenterol 12:3496-511. 2006
    ..Glucagon and secretin are two relevant hormones which seem to act very similarly in their target cells (hepatocytes for the former and ..
  94. ncbi Interactions of VIP, secretin and PACAP(1-38) with phospholipids: a biological paradox revisited
    A Krishnadas
    Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612 7323, USA
    Curr Pharm Des 9:1005-12. 2003
    Vasoactive intestinal peptide (VIP), secretin and pituitary adenylate cyclase-activating peptide(1-38)(PACAP(1-38)) are widely distributed amphipathic mammalian neuropeptides that exert diverse biological effects in target tissues located ..
  95. ncbi Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger
    Jesus M Banales
    Laboratory of Molecular Genetics, Division of Gene Therapy and Hepatology, University of Navarra School of Medicine, Clinica Universitaria and CIMA, Pamplona, Spain
    Hepatology 43:266-75. 2006
    ..bile ducts through reabsorptive and secretory processes regulated by nerves, bile salts, and hormones such as secretin. Secretin stimulates ductular cystic fibrosis transmembrane conductance regulator (CFTR)-dependent Cl- efflux and ..
  96. pmc Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    J Mol Neurosci 36:254-9. 2008
    ..This results in the exposure of a "hidden endogenous agonist" (WDN sequence in secretin and VPAC1 receptors) within the receptor amino terminus that interacts with the receptor core, thereby changing ..
  97. ncbi Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy
    Hiroyuki Shinchi
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, 890 8520, Kagoshima, Japan
    J Hepatobiliary Pancreat Surg 11:50-5. 2004
    The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin-MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with ..
  98. ncbi Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily
    J Hamann
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
    Genomics 32:144-7. 1996
    ..The membrane-spanning region of both molecules is homologous to the secretin receptor (SecR) superfamily, a group of receptors with specificity for mammalian and insect peptide hormones...
  99. pmc An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    FASEB J 24:5024-32. 2010
    ..In the present study, we show initially that the osmoregulatory functions of secretin (SCT) in the brain are similar to those of ANGII in mice and, more important, we discovered the role of SCT as ..
  100. ncbi Retinoic acid activates human secretin gene expression by Sp proteins and nuclear factor I in neuronal SH-SY5Y cells
    Leo Tsz On Lee
    Department of Zoology, The University of Hong Kong, Hong Kong, China
    J Neurochem 93:339-50. 2005
    b>Secretin is a neuropeptide that is expressed in distinct central neurones...
  101. pmc Prospective comparison of secretin-stimulated MRCP with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III
    John Baillie
    Hepatobiliary and Pancreatic Disorders Service, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Gut 56:742-4. 2007

Research Grants64

  1. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..Aim 1 will examine how NeuroD associates with Sp1, RREB1, and LSD1 at one its known targets, the secretin gene to form a multiprotein coactivator complex...
  2. Immunogenicity of the Type IV Secretin System
    WENDY CATHERINE BROWN; Fiscal Year: 2012
    ..The results of this project will be generally applicable vaccine development for many human bacterial diseases. ..
  3. Novel Breath Test To Detect Early Stage Chronic Pancreatitis
    DAVID A contact WAGNER; Fiscal Year: 2010
    ..A more sensitive test to detect mild to moderate CP is the secretin stimulation test...
  4. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ..and oxytocin, and hormones that we have recently identified as neuromodulators made by the placenta, such as secretin, will be assessed...
  5. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    MARTIN CONRAD CAREY; Fiscal Year: 2013
    ..sludge" and gallstone formation associated with total parenteral nutrition, focusing on the lack of CCK and secretin from enteral starvation...
  6. A Novel Mitigation Agent for Gastrointestinal Syndrome of Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2009
    ..Survival (LD50/7), GI function (stool hemoccult;gross evaluation of stool formation;plasma secretin, amylase, glucose, and insulin) as well as systemic surrogate marker (levels of endotoxin and inflammatory ..
  7. The Psp response of Yersinia enterocolitica
    Andrew J Darwin; Fiscal Year: 2013
    ..A critical component of all T3SSs is a specialized outer membrane pore-forming protein known as a secretin. However, secretin production can cause bacterial cell envelope stress. This is lethal to Y...
  8. Functioning of Nodose Ganglia in Diabetes
    Chung Owyang; Fiscal Year: 2013
    ..by in vivo electrophysiological recording of NG in diabetic rats and study its responsiveness to CCK, leptin and secretin stimulation...
  9. Structural Biology of Class B G-Protein Coupled Receptors
    H Eric Xu; Fiscal Year: 2010
    ..The secretin family of Class B GPCRs consists of 15 members in humans, including receptors for parathyroid hormone (PTH), ..
  10. Autocrine/Paracrine Regulation of Intrahepatic Bile Duct Growth
    GIANFRANCO D ALPINI; Fiscal Year: 2013
    ..b>Secretin receptor (SR) has been suggested to play a role in the regulation of cholangiocyte growth/loss since there is: (i)..
  11. Role of Neuropeptides in Anxiety
    Valentina Sabino; Fiscal Year: 2013
    ..of Boston, concerns the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/VIP superfamily, and a pleiotropic molecule with remarkable central actions on neuroendocrine and ..
  12. DEVELOPING METHODS FOR CRYSTALLIZING FAMILY C GPCRS
    Dan Feng; Fiscal Year: 2013
    ..are commonly divided into five families by sequence and structural similarity, specified as Rhodopsin (Family A), Secretin (Family B), Glutamate (Family C), Adhesion, and Frizzled/Taste2...
  13. EUS Diagnosis of Chronic Pancreatitis
    Timothy B Gardner; Fiscal Year: 2013
    ..Finally Dr. Gardner will perform combined secretin-enhanced EUS in patients with suspected CP to learn the duodenal bicarbonate concentration in subjects with and ..
  14. Mechanisms of antibiotic action in Neisseria gonorrhoeae.
    Robert A Nicholas; Fiscal Year: 2010
    ..We have recently uncovered a surprising role in antibiotic influx of the PilQ secretin, one of the proteins in the Type IV pilus complex, which is involved in adhesion and invasion, twitching motility,..
  15. Molecular Mechanisms of Acute Pancreatitis
    Craig D Logsdon; Fiscal Year: 2013
    ..We will also investigate the effects of the secretagogues neuromedin b and secretin, which do not induce pancreatitis in control animals, to determine whether their signaling mechanisms will ..
  16. GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE
    GIANFRANCO D ALPINI; Fiscal Year: 2010
    ..the calcium-dependent transcription factor, NFAT, stimulates small cholangiocyte proliferation with activation of secretin receptor (SR) and cystic fibrosis transmembrane regulator (CFTR) expression;(ii) neural- dependent modulation of ..
  17. PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATES
    WILLIAM SPIVAK; Fiscal Year: 1990
    ..to bile may contribute to the development of cholestasis in premature infants where the driving force for bile secretin may not be sufficient to oppose high intracanalicular viscosities...
  18. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..CCK-8 and gastrin as possible neural or endocrine mediators of secretory stimulation and somatostatin, galanin, secretin and PYY as possible paracrine, neural or endocrine mediators of secretory inhibition will be determined...
  19. Secretin Receptor Structure, Function and Regulation
    Laurence J Miller; Fiscal Year: 2013
    The secretin receptor is prototypic of Family B G protein-coupled receptors, a group containing several important potential drug targets...
  20. ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEA
    JOHN FORDTRAN; Fiscal Year: 2002
    ..Our research techniques includes metabolic balance methods to measure net gastrointestinal absorption or secretin of nutrients, minerals and electrolytes; or steady state intestinal perfusion which allows detailed examination ..
  21. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1991
    ..I. hormones (secretin, gastrin, and CCK) and growth factors e.g...
  22. CONTROL OF GASTRIC SECRETION
    BASIL HIRSCHOWITZ; Fiscal Year: 1980
    ..Pentagastrin dose responses, sham-feeding, and gastrin release by food, secretin and sham-feeding, and basal acid inhibition by graded doses of atropine and H-2 antagonists are being studied in ..
  23. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
    ..PACAP/VIP amino acid homology with the other related peptides, including growth hormone releasing hormone (GHRH), secretin, glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, and glucose-dependent insulinotropic peptide (GIP) is more ..
  24. MECHANISM OF DIETARY ADAPTATION OF PANCREATIC FUNCTION
    PATSY BRANNON; Fiscal Year: 1990
    ..The effects of fatty acids and their interaction with secretin and ketones in the regulation of both enzymes will be examined in cultured cells...
  25. EFFECT OF ALCOHOL ON PANCREATIC SECRETION
    Jorge Valenzuela; Fiscal Year: 1990
    ..the effect of alcohol ingestion in the form of common alcoholic beverages ion the release of GI peptides, CCK, secretin. gastrin and PP and on pancreatic exocrine secretion...
  26. MODULATORS OF GASTRIC HISTAMINE RELEASE IN VIVO
    John Gerber; Fiscal Year: 1993
    ..These compounds include antisecretory polypeptides somatostatin, glucagon, and secretin; antisecretory autocoids prostaglandins E2 and I2, and adenosine; sympathomimetic isoproterenol,and the histamine-..
  27. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    The objective of this proposal is to study the mechanisms of secretion and action of secretin (S) and cholecystokinin (CCK)...
  28. FEEDBACK REGULATION OF PANCREATIC SECRETION
    Gary Green; Fiscal Year: 2000
    ..Additional studies will test whether LCRF has secretin-releasing activity, based on LCRF-stimulation of a higher/fluid protein ratio of pancreatic secretion compared to ..
  29. CELLULAR REGULATION OF HEPATOCYTE EXCRETORY FUNCTION
    EDWARD OLINGER; Fiscal Year: 1980
    ..METHODS: a. Isolated hepatocyte suspensions and cultures prepared from adult rat liver. b. Hormones: Gastrin, secretin, cholecystokinin, glucagon, and thyroxine added to liver cells in vitro. c...
  30. BIOSYNTHESIS OF SECRETIN
    Alan Kopin; Fiscal Year: 1993
    ..The long term goal of this proposal is to elucidate the biological role of secretin, a gastrointestinal hormone which regulates pancreatic secretion...
  31. NOVEL SECRETIN RECEPTOR INTERACTING PROTEINS
    Michael Shetzline; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Secretin modulates gastric acid release, intestinal motility and pancreatic water and bicarbonate secretion leading to neutralization of acidic chyme...
  32. DIFFERENTIATION OF ENDOCRINE CELL LINEAGES IN GI TRACT
    Andrew Leiter; Fiscal Year: 2001
    ..transcriptional controls that direct the differentiation of two endocrine cell types (cholecystokinin and secretin) precursor cells...
  33. MECHANISMS OF PEPSINOGEN SECRETION FROM CHIEF CELLS
    Jean Pierre Raufman; Fiscal Year: 1990
    ..These cells have been used to determine that changes in cAMP mediate the actions of secretin, vasoactive intestinal peptide, prostaglandins, and cholera toxin, whereas changes in cell calcium concentration ..
  34. RAT PAROTID EXOCYTOSIS
    David Quissell; Fiscal Year: 1992
    ..an integral membrane phosphoprotein (pp26) which appears to be directly involved in regulating rat parotid secretin following B-adrenergic receptor stimulation.l Peptide mapping, and protein sequencing studies will be done...
  35. PANCREATIC PHYSIOLOGY STUDIES
    MORTON GROSSMAN; Fiscal Year: 1980
    ..The effect of atropine and vagotomy on secretory response to secretin and HCl will be determined...
  36. ALCOHOL & PANCREATIC DIGESTIVE ENZYME SYNTHESIS
    BIDDANDA PONNAPPA; Fiscal Year: 1991
    ..synthesis and turnover is mediated by the release of gastrointestinal hormones such as cholecystokinin and secretin will be tested...
  37. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2004
    ..b>Secretin plays an important role in this process, mediating duodenal acid-induced gastric relaxation by acting on vagal ..
  38. EXOCYTOSIS AND LATROTOXIN RECEPTOR IN CHROMAFFIN CELLS
    RONALD HOLZ; Fiscal Year: 2001
    ..cleavable extracellular alpha-Ltx binding domain, and a 7-TM domain that has moderate identity and homology with secretin receptors. CIRL can also bind to syntaxin...
  39. EXPRESSION & FUNCTION OF MACROPHAGE MANNOSE RECEPTORS
    Philip Stahl; Fiscal Year: 2003
    ..IL-6 amd IL-12 secretin will be used as readouts...
  40. REPRODUCTIVE PHYSIOLOGY OF OVARIAN FAILURE
    Nanette Santoro; Fiscal Year: 2003
    Our group has previously reported striking increases in estrogen secretin and excretion in women in the early stage of the menopause transition...
  41. CALCIUM-ACTIVATED PROTEIN KINASES AND INSULIN SECRETION
    RICHARD EASOM; Fiscal Year: 2000
    Glucose-induced insulin secretin is defective in type II diabetics mellitus...
  42. GASTRIC ACID SECRETION
    George Sachs; Fiscal Year: 1992
    ..patch and whole cell recording to monitor channels and membrane expansion that is associated with activation of secretin. Electron microscopy, using acid space dependent probes, will be used in isolated intact of permeable rabbit ..
  43. MOLECULAR BASIS OF SECRETIN RECEPTOR REGULATION
    Michael Shetzline; Fiscal Year: 2002
    b>Secretin modulates gastric acid release, intestinal motility and pancreatic water and bicarbonate secretion leading to neutraliza-tion of acidic chyme...
  44. CIRL RECEPTOR FAMILY AND SECRETION
    Konstantin Ichtchenko; Fiscal Year: 2001
    ..transmembrane hydrophobic segments, a hallmark of GPCRs, and are significantly homologous to the members of the secretin receptor family of GPCRs...
  45. PANCREATIC CARCINOGENESIS: ROLE OF DUODENAL REFLUX
    Eugene DiMagno; Fiscal Year: 1980
    ..perfused marker within the pancreatic duct in a minority of dogs during fasting; 3) determined that hormones (secretin and cholecystokinin/octapeptide) maintain or cause a fall in the pancreatic duct pressure to duodenal pressure ..
  46. HORMONAL REGULATION OF ISOLATED GASTRIC MUCOSAL CELLS
    Gary Rosenfeld; Fiscal Year: 1980
    ..Cholinergic, adrenergic, and histaminic agonists and antagonists as well as polypetide hormones (gastrin, secretin, glucagon, insulin, and cholecystikinin) and prostaglandins will be studied using these isolated cells...
  47. Autism Therapeutics: Novel Secretin Receptor Agonists
    David Evans; Fiscal Year: 2002
    ..robotic system we plan to screen a library of 70,000 small molecules (each <700 daltons) for agonists at the secretin receptor transfected into cells...
  48. CELL-SPECIFIC REGULATION OF SECRETIN GENE EXPRESSION
    Andrew Leiter; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Understanding how secretin gene expression is restricted to secretin cells in the gut is an attractive model for examining transcriptional control of intestinal differentiation...
  49. Improved Secretin Analogs for the Treatment of Autism
    Richard Boismenu; Fiscal Year: 2002
    b>Secretin is a naturally occurring, short-lived 27 amino acid neuropeptide hormone...
  50. RECEPTOR DIRECTED SUPERPARAMAGNETIC MRI CONTRAST AGENTS
    KENNETH PAUL; Fiscal Year: 1992
    ..g. somatostatin, cholecystokinin, vasoactive intestinal peptide, secretin, and CRP/bombesin)...
  51. PEPTIDE HORMONE PRODUCTION IN E COLI
    Keiichi Itakura; Fiscal Year: 1980
    ..coli and used for the expression of synthetic genes for peptide hormones. A gene for secretin will be designed, synthesized and expressed in E. coli...
  52. REGULATION OF SECRETION BY BILE DUCT EPITHELIAL CELLS
    JOHN FITZ; Fiscal Year: 2001
    ..cholangiocytes also express a rich array of other channels that are regulated by both receptor-dependent (secretin, ATP) and -independent (bile acids, cell volume) pathways...
  53. Regulation of Neural Precursors: Role of Neuropeptides
    James Waschek; Fiscal Year: 2006
    Pituitary adenylyl cyclase activating peptide (PACAP) is a neuropeptide in the secretin family with potential significance in a range of brain afflictions, including mental retardation, autism, neurodegenerative diseases, CNS injury, and ..
  54. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 2002
    ..this gene disrupts proper islet morphogenesis and eliminates the formation of two types of enteroendocrine cells: secretin and cholecystokinin producing cells. The animals develop severe diabetes and die within 3-5 days after birth...
  55. MOLECULAR BASIS OF LOCALIZED ADHERENCE IN E. COLI
    Michael Donnenberg; Fiscal Year: 2009
    ..3. To define the topology and binding interactions of BfpB. The topology of the outer membrane secretin protein BfpB will be defined by systematic insertion of epitopes and protease cleavage sites into the protein to ..
  56. SURFACE CONTACT MODULATION OF PHAGOCYTE FUNCTION
    PAUL GUDEWICZ; Fiscal Year: 1990
    ..of these proposed studies will provide not only new information on how the extracellular matrix proteins modulate phagocytic activity, but also new insights into the regulation of phagocyte function and secretin at sites of tissue injury.
  57. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  58. The Psp response of Yersinia enterocolitica
    Andrew Darwin; Fiscal Year: 2008
    ..A critical component of all T3SSs is a specialized outer membrane pore-forming protein known as a secretin. However, secretin production can cause bacterial cell envelope stress. This is lethal to Y...
  59. Therapeutic Placebos as Complementary Therapy in ADHD
    Adrian Sandler; Fiscal Year: 2004
    ....
  60. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..Recent success to isolate IBDU from normal mouse yielded intact polarized functional IBDU that responds to secretin, vasoactive intestinal peptide, and DBcAMP/IBMX...