- Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
R S Lanciotti
Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
Science 286:2333-7. 1999
..This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998...
- Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
D W Vaughn
Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
J Infect Dis 181:2-9. 2000
..6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type...
Scott B Halstead
Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
Lancet 370:1644-52. 2007
..Here, I review and discuss data on clinical diagnosis and pathophysiology of vascular permeability and coagulopathy, parenteral treatment of DHF/DSS, and new laboratory tests...
- B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
Michael S Diamond
Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Virol 77:2578-86. 2003
..We conclude that antibodies and B cells play a critical early role in the defense against disseminated infection by WNV...
- Neutralization and antibody-dependent enhancement of dengue viruses
Scott B Halstead
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Adv Virus Res 60:421-67. 2003
- Fruit bats as reservoirs of Ebola virus
Eric M Leroy
Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
Nature 438:575-6. 2005
..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
- Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
Nat Struct Mol Biol 16:265-73. 2009
..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
- Introduction of West Nile virus in the Middle East by migrating white storks
Kirmon Veterinary Institute, Beit Dagan, Isreal
Emerg Infect Dis 8:392-7. 2002
..Since these storks were migrating southwards for the first time and had not flown over Israel, we assume that they had become infected with WNV at some point along their route of migration in Europe...
- Efficient intracellular assembly of papillomaviral vectors
Christopher B Buck
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
J Virol 78:751-7. 2004
..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
- Nipah virus: a recently emergent deadly paramyxovirus
K B Chua
Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
Science 288:1432-5. 2000
..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
- The stoichiometry of antibody-mediated neutralization and enhancement of West Nile virus infection
Theodore C Pierson
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Cell Host Microbe 1:135-45. 2007
..Thus, neutralization is best described by a model requiring "multiple hits" with the cumulative functional outcome determined by interplay between antibody affinity and epitope accessibility...
- The outbreak of West Nile virus infection in the New York City area in 1999
Communicable Disease Program, New York City Department of Health, New York 10013, USA
N Engl J Med 344:1807-14. 2001
..The initial epidemiologic and environmental investigations suggested an arboviral cause...
- Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 361:1945-52. 2009
- Structural basis of West Nile virus neutralization by a therapeutic antibody
Grant E Nybakken
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 437:764-9. 2005
..Collectively, our results suggest that a vaccine strategy targeting the dominant DIII epitope may elicit safe and effective immune responses against flaviviral diseases...
- Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
Suzanne L Epstein
Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Bethesda, MD 20852, USA
Vaccine 23:5404-10. 2005
..Thus, gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity...
- Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
Cytos Biotechnology, Schlieren, Switzerland
J Immunol 172:5598-605. 2004
- Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
Timothy P Endy
Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
J Infect Dis 189:990-1000. 2004
..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...
- West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis
S Y Xiao
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
Emerg Infect Dis 7:714-21. 2001
..Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis...
- Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
Vincent C Lombardi
Whittemore Peterson Institute, Reno, NV 89557, USA
Science 326:585-9. 2009
..These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS...
- Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
Shee Mei Lok
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Nat Struct Mol Biol 15:312-7. 2008
..The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells...
- Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
James W Huleatt
VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
Vaccine 26:201-14. 2008
..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
- Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity
S B Boppana
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
N Engl J Med 344:1366-71. 2001
..Whether congenital CMV infection in the offspring of women who are seropositive for CMV can occur after maternal reinfection with a different strain of CMV is unknown...
- Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey
Communicable Disease Program, New York City Department of Health, NY 10013, USA
Lancet 358:261-4. 2001
..We did a household-based seroepidemiological survey to assess more clearly the public-health impact of the epidemic, its range of illness, and risk factors associated with infection...
- Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes
Wayne D Crill
Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
J Virol 78:13975-86. 2004
..The third epitope consists of discontinuous residues that are structurally related to the strictly conserved tryptophan at dengue virus serotype 2 E-glycoprotein position 231...
- Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
Department of Medicine, University of Washington, Seattle 98122, USA
N Engl J Med 342:844-50. 2000
..Historically, it has been assumed that these persons have less frequent viral reactivation than those with symptomatic infection...
- Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40
Wendy A Knowles
Enteric, Respiratory and Neurological Virus Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, United Kingdom
J Med Virol 71:115-23. 2003
..There is no serological evidence that SV40 entered the human population during the past 80 years, and the possibility of cross-reaction with BKV or JCV antibody must be considered...
- Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
W D Crill
Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
J Virol 75:7769-73. 2001
..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
- Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
J Vet Diagn Invest 19:591-615. 2007
..This article is intended to discuss the most common disease manifestations, pathogenesis, diagnostic approaches, and intervention strategies associated with PCVAD in North America...
- Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement
Medical Molecular Biology Unit, Siriraj Hospital, Mahidol University, Bangkok, Thailand
J Infect Dis 193:1078-88. 2006
..Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown...
- Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
Yanis L Tolstov
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Int J Cancer 125:1250-6. 2009
..Our study demonstrates that MCV is a widespread but previously unrecognized human infection...
- A critical role for induced IgM in the protection against West Nile virus infection
Michael S Diamond
Washington University School of Medicine, 660 S Euclid Ave, Box 8051, St Louis, MO 63110, USA
J Exp Med 198:1853-62. 2003
..Thus, the induction of a specific, neutralizing IgM response early in the course of WNV infection limits viremia and dissemination into the central nervous system, and protects against lethal infection...
- High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up
L L Villa
Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 01509 010 Sao Paulo, SP, Brazil
Br J Cancer 95:1459-66. 2006
..This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts...
- Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18
Diana V Pastrana
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
Virology 321:205-16. 2004
..The SEAP pseudovirus-based neutralization assay should be a practical method for quantifying potentially protective antibody responses in HPV natural history and prophylactic vaccine studies...
- Serotype-specific differences in clinical manifestations of dengue
Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
Am J Trop Med Hyg 74:449-56. 2006
..86, CI 2.72-5.48) and more primary DENV infections with severe manifestations (OR 2.93, CI 2.00-4.28). These findings provide new data to characterize the pathogenic potential of distinct DENV serotypes in human populations...
- European bat lyssavirus infection in Spanish bat populations
Universitat de Barcelona, Barcelona, Spain
Emerg Infect Dis 8:413-20. 2002
..At least one of this species (M. schreibersii) is migratory and thus could be partially responsible for the dissemination of EBL1 on both shores of the Mediterranean Sea...
- Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus
Crucell Holland B V, P O Box 2048, 2301 CA, Leiden, The Netherlands
J Virol 80:6982-92. 2006
- Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2
Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
Vaccine 21:2616-26. 2003
..Importantly, the protection in M2e-MAP- and infection-immunized mice appeared to be mediated by distinct immune mechanisms. This suggests that stronger protection may be achievable by combining both protective activities...
- Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
Angelo De Milito
Microbiology and Tumor Biology Center, Karolinska Institute, and Gay Men s Health Clinic, The Soder Hospital, Stockholm, Sweden
Blood 103:2180-6. 2004
..Our results may be relevant to the design of HIV-1 therapeutical vaccines and to the clinical management of HIV-1-infected patients...
- The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
Gunilla B Karlsson Hedestam
Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
Nat Rev Microbiol 6:143-55. 2008
..Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens...
- Quantitation of human seroresponsiveness to Merkel cell polyomavirus
Diana V Pastrana
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA
PLoS Pathog 5:e1000578. 2009
..This suggests that a VLP-based vaccine could be effective for preventing the initial establishment of MCV infection...
- Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
William M Switzer
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 78:2780-9. 2004
..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
- A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection
Theodore C Pierson
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Virology 346:53-65. 2006
..WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody...
- Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay
Virus and Cell Biology, Merck Research Laboratories, Wayne, Pennsylvania 19087 8630, USA
Clin Diagn Lab Immunol 10:108-15. 2003
- The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection
Kao Jean Huang
Department of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Immunol 176:2825-32. 2006
- Correlation between direct ELISA, single epitope-based inhibition ELISA and pseudovirion-based neutralization assay for measuring anti-HPV-16 and anti-HPV-18 antibody response after vaccination with the AS04-adjuvanted HPV-16/18 cervical cancer vaccine
Francis J Dessy
Research and Development, GlaxoSmithKline Biologicals, Rixensart, Belgium
Hum Vaccin 4:425-34. 2008
..4 years) and the age of the vaccine recipient...
- Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
Kathryn B Renegar
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 173:1978-86. 2004
- Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia
J M Yob
Veterinary Research Institute, Ipoh, Perak, Malaysia
Emerg Infect Dis 7:439-41. 2001
..We collected 324 bats from 14 species on peninsular Malaysia. Neutralizing antibodies to Nipah virus were demonstrated in five species, suggesting widespread infection in bat populations in peninsular Malaysia...
- Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles
Thanh Hung Nguyen
Department of Dengue Hemorrhagic Fever, Children s Hospital No 1 Ho Chi Minh City, Vietnam
J Infect Dis 189:221-32. 2004
..Overproduction of both proinflammatory cytokines (interferon-gamma and tumor necrosis factor-alpha) and anti-inflammatory cytokines (interleukin-10 and -6) may play a role in the pathogenesis of DHF/DSS in infants...
- Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
Y C Chien
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
N Engl J Med 345:1877-82. 2001
..CONCLUSIONS: IgA antibodies against EBV capsid antigen and neutralizing antibodies against EBV DNase are predictive of nasopharyngeal carcinoma...
- Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide
Damian Guang Wei Foo
Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
Microbes Infect 9:1299-306. 2007
..In conclusion, EV71-neutralizing antibodies elicited by the synthetic peptide SP70 were able to confer good in vivo passive protection against homologous and heterologous EV71 strains in suckling Balb/c mice...
- Dengue: an update
Maria G Guzman
Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6, PO Box Marianao 13, Ciudad Habana, Cuba
Lancet Infect Dis 2:33-42. 2002
..We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti...
- Development of a fluorescent antibody virus neutralisation test (FAVN test) for the quantitation of rabies-neutralising antibody
CNEVA Nancy, Laboratoire d études sur la rage et la pathologie des animaux sauvages, Malzeville, France
J Immunol Methods 212:79-87. 1998
..Furthermore, distinguishing negative sera from positive sera with low titres is much easier with the FAVN test than with the RFFIT...
- Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections
V C Huber
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
J Immunol 166:7381-8. 2001
..We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections...
- Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Brain 131:1712-21. 2008
..Our data show high levels of CD8+ T-cell activation against EBV--but not CMV--early in the course of MS, which support the hypothesis that EBV might be associated with the onset of this disease...
- Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
Crucell Holland BV, Leiden, The Netherlands
PLoS ONE 3:e3942. 2008
..Furthermore, there are 16 different HA subtypes and no certainty the next pandemic will be caused by an H5 subtype, thus it is important to develop prophylactic and therapeutic interventions that provide heterosubtypic protection...
- Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study
Division of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
Lancet Neurol 6:773-81. 2007
..Our aim was to determine some of these characteristics in children with MS...
- Safety and immunogenicity of a prototype adjuvanted inactivated split-virus influenza A (H5N1) vaccine in infants and children
Melbourne School of Population Health, The University of Melbourne, Victoria, Australia
Vaccine 26:6383-91. 2008
- Human metapneumovirus infections in young and elderly adults
Ann R Falsey
Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
J Infect Dis 187:785-90. 2003
..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
- West Nile outbreak in horses in southern France, 2000: the return after 35 years
Centre National de Référence des Arbovirus et des Fièvres hémorragiques virales, Institut Pasteur 25, rue du Dr Roux, 75724 Paris Cedex 15, France
Emerg Infect Dis 7:692-6. 2001
..No human case has been confirmed among clinically suspected patients, nor have abnormal deaths of birds been reported. A serosurvey has been undertaken in horses in the infected area, and other studies are in progress...
- Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar
Institut Pasteur de Madagascar, Antananarivo, Madagascar
Emerg Infect Dis 13:159-61. 2007
..Antibodies against Nipah, Hendra, and Tioman viruses were detected by immunoassay in 23 and by serum neutralization tests in 3 of 427 serum samples, which suggests that related viruses have circulated in Madagascar...
- Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in Laos
Stuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Diagn Microbiol Infect Dis 60:43-9. 2008
- The detection of antibodies against peste des petits ruminants virus in cattle, sheep and goats and the possible implications to rinderpest control programmes
ARFC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK
Epidemiol Infect 112:225-31. 1994
- Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 78:10230-7. 2004
..Three immunizations with the three-protein combination were necessary and sufficient for complete protection. These studies suggest the feasibility of a multiprotein smallpox vaccine...
- Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:191-202. 2003
..Our findings illustrate the uniqueness of each serotype in producing epidemics and severe disease and underscore the importance of long-term surveillance of dengue serotypes in understanding the epidemiology of these viruses...
- An outbreak of Rift Valley fever in Northeastern Kenya, 1997-98
Christopher W Woods
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 8:138-44. 2002
..Public education during epizootics may reduce human illness and deaths associated with future outbreaks...
- Functional role of type I and type II interferons in antiviral defense
Institute of Molecular Biology I, University of Zurich, Switzerland
Science 264:1918-21. 1994
..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
- Studies of reservoir hosts for Marburg virus
National Institute for Communicable Diseases, Sandringham, Republic of South Africa
Emerg Infect Dis 13:1847-51. 2007
..6% of 2 species of insectivorous bat and 1 species of fruit bat. We found antibody to the virus in the serum of 9.7% of 1 of the insectivorous species and in 20.5% of the fruit bat species, but attempts to isolate virus were unsuccessful...
- Guidelines for Plaque-Reduction Neutralization Testing of Human Antibodies to Dengue Viruses
John T Roehrig
National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, Colorado, USA
Viral Immunol 21:123-32. 2008
..A more complete version of these guidelines is available on the WHO website: http://www.who.int/immunization/documents/date/en/index.html...
- Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II
Chih Yun Lai
Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Virol 82:6631-43. 2008
..These findings have implications for our understanding of the pathogenesis of dengue and for the future design of subunit vaccine against DENV as well...
- A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity
William F McDonald
VaxInnate Corporation, New Haven, CT 06511, USA
J Infect Dis 195:1607-17. 2007
..They also support the further development of an effective WNV vaccine and novel monovalent and multivalent vaccines for related flaviviruses...
- Occupancy and mechanism in antibody-mediated neutralization of animal viruses
P J Klasse
Jefferiss Research Trust Laboratories, Wright Fleming Institute, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
J Gen Virol 83:2091-108. 2002
..Examples of neutralization mediated through antibody interference with virus attachment and entry are discussed and test implications of refined theories of neutralization by antibody coating of virions are formulated...
- Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors
K T Jørgensen
Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen, Denmark
Ann Rheum Dis 67:860-6. 2008
To assess the timing of changes in cytokines, cytokine-related markers, autoantibodies and viral antibodies in the pathogenesis of rheumatoid arthritis (RA).
- Monoclonal antibody mapping of the envelope glycoprotein of the dengue 2 virus, Jamaica
J T Roehrig
Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
Virology 246:317-28. 1998
..Domains A and B were spatially associated. As with tick-borne encephalitis virus, determination of domain C was more problematic; however, at least four epitopes had biochemical characteristics consistent with C-domain epitopes...
- Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
Victor C Huber
Deparment of Infectious Disease, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Clin Vaccine Immunol 13:981-90. 2006
..This study details separate but important roles for both IgG1 and IgG2a expression in vaccination against influenza and argues for the development of vaccine regimens that stimulate and measure expression of both antibody isotypes...
- Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
Jeffrey E Lee
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Drop IMM 2, La Jolla, California 92037, USA
Nature 454:177-82. 2008
..This structure provides a template for unravelling the mechanism of EBOV GP-mediated fusion and for future immunotherapeutic development...
- Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a postattachment step
Matthew R Vogt
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Virol 83:6494-507. 2009
..CR4348 and CR4354 human MAbs neutralize infection at a postattachment step in the viral life cycle, likely by inhibiting acid-induced fusion within the endosome...
- Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness
Influenza Division, Mailstop G 16, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Clin Vaccine Immunol 14:1425-32. 2007
..These studies indicate that H7N2-PR8 is immunogenic, safe, and protective in animal models; these are the essential attributes to qualify for phase I human clinical trials as a prepandemic vaccine...
- Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY, USA
J Infect Dis 200:172-80. 2009
..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed...
- Transmission of West Nile virus from an organ donor to four transplant recipients
Epidemic Intelligence Service, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
N Engl J Med 348:2196-203. 2003
..In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected...
- Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus
Gregory D Gromowski
Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Virology 366:349-60. 2007
..Overall, the conserved antigenic site recognized by all seven MAbs is likely to be a dominant DENV-2 type-specific, neutralization determinant...
- West Nile virus activity in Latin America and the Caribbean
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, Colorado 80522, USA
Rev Panam Salud Publica 19:112-7. 2006
..West Nile virus (Flavivirus: Flaviviridae; WNV) has spread rapidly throughout the Caribbean Basin since its initial detection there in 2001. This report summarizes our current knowledge of WNV transmission in tropical America...
- Isolation of Nipah virus from Malaysian Island flying-foxes
Kaw Bing Chua
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Lumpur, Kuala, Malaysia
Microbes Infect 4:145-51. 2002
..The isolation of Nipah virus from the Island flying-fox corroborates the serological evidence that it is one of the natural hosts of the virus...
- Susceptibility of North American big brown bats (Eptesicus fuscus) to infection with European bat lyssavirus type 1
Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G33, Atlanta, GA 30333, USA
J Gen Virol 89:1998-2010. 2008
..d.) routes could lead to an abortive infection and serve as a natural mode of immunization resulting in the presence of virus-neutralizing antibodies in free-ranging bats...
- Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic
Service des Urgences, Centre Hospitalier Universitaire, Fort de France, Martinique
Am J Trop Med Hyg 78:990-8. 2008
..The most severe cases of dengue resulted from the combined effects of DENV-2 and secondary infection...
- Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads
Yu Wen Lin
Institute of Biomedical Sciences, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
J Virol 83:6477-83. 2009
..Our study suggests the use of vaccines and virus-specific antibodies to control fatal outbreaks and raises caution over the use of corticosteroids to treat EV71-infected patients with neurological symptoms...
- High seroprevalence of Epstein-Barr virus in children with multiple sclerosis
Brauweg 19, 37073 Goettingen, Germany
Neurology 67:2063-5. 2006
..6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls...
- A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies
Nigel J Temperton
MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
Influenza Other Respir Viruses 1:105-12. 2007
..We have used retroviral pseudotypes bearing influenza H5 hemagglutinin (HA) as safe, surrogate viruses for influenza neutralization assays which can be carried out at Biosafety Level 2...
- Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins
A K Falconar
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, U K
Arch Virol 144:2313-30. 1999
..These peptide sequence will now be tested for their ability to generate cross-protective antibodies against each dengue virus serotype when delivered with appropriate T-helper epitopes...
- Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
J Gen Virol 89:2204-13. 2008
- Effect of preexisting immunity on an adenovirus vaccine vector: in vitro neutralization assays fail to predict inhibition by antiviral antibody in vivo
Susan L Pichla-Gollon
Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Virol 83:5567-73. 2009
..The results thus suggest that in vitro neutralization assays may not reliably predict the effects of virus-specific antibodies on adenovirus vectors in vivo...
- Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees
Christopher W Olsen
University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Emerg Infect Dis 8:814-9. 2002
..Because pigs can play a role in generating genetically novel influenza viruses, swine farmers may represent an important sentinel population to evaluate the emergence of new pandemic influenza viruses...
- Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis
Lynn I Levin
Division of Preventive Medicine, Walter Reed Army Institute of Research, Silver Spring, MD, USA
JAMA 293:2496-500. 2005
..Infection with Epstein-Barr virus (EBV) has been associated with an increased risk of multiple sclerosis (MS), but the temporal relationship remains unclear...
- Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
Nat Med 8:373-8. 2002
..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
- Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus)
Raina K Plowright
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Proc Biol Sci 275:861-9. 2008
..These insights into the ecology of HeV in flying fox populations suggest causal links between anthropogenic environmental change and HeV emergence...
- Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 4:e1000060. 2008
..Thus, in addition to a role in facilitating viral entry, changes in E protein arrangement associated with maturation modulate neutralization sensitivity and introduce an additional layer of complexity into humoral immunity against WNV...
- Response to a monovalent 2009 influenza A (H1N1) vaccine
Michael E Greenberg
Clinical Research and Development, CSL, Parkville, Vic, Australia
N Engl J Med 361:2405-13. 2009
..A randomized, observer-blind, parallel-group trial evaluating two doses of an inactivated, split-virus 2009 H1N1 vaccine in healthy adults between the ages of 18 and 64 years is ongoing at a single site in Australia...
- Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
William M Switzer
Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Retrovirology 7:57. 2010
..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
- Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice
Jes G Kuruvilla
Department of Microbiology, Immunology and Pathology, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1619, USA
Virology 369:143-52. 2007
..These results demonstrate for the first time that humanized mice are capable of dengue viral primary human immune responses thus paving the way for new dengue immunopathogenesis and vaccine studies...
- Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
Maria Grazia Revello
Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Clin Microbiol Rev 15:680-715. 2002
- Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays
Center for Emerging Infectious Diseases, Department of Epidemiology, College of Public Health, University of Iowa, Oakdale Research Park, MTF B145, 2501 Crosspark Road, Coralville, IA 52241 8802, United States
J Clin Virol 43:73-8. 2008
..Recent research suggests that the sensitivity of the HI assay can be improved by switching from the traditionally used turkey, guinea pig, human, or chicken RBCs to horse RBCs...
- Serologic evidence of frequent human infection with WU and KI polyomaviruses
Nang L Nguyen
Washington University in St Louis, Missouri 63110, USA
Emerg Infect Dis 15:1199-205. 2009
..These results demonstrate that both KIPyV and WUPyV cause widespread infection in the human population...