organic cation transport proteins

Summary

Summary: A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body.

Top Publications

  1. ncbi Carnitine transport by organic cation transporters and systemic carnitine deficiency
    K Lahjouji
    Division of Medical Genetics, , 3175 Cote Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada
    Mol Genet Metab 73:287-97. 2001
  2. ncbi Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity
    Hiromu Katsuda
    Department of Medicinal Informatics, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Biol Pharm Bull 33:1867-71. 2010
  3. ncbi Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    David Alexandre Tregouet
    Institut National de la Santé Et de la Recherche Médicale INSERM Unité Mixte de Recherche UMR_S 525, Université Pierre et Marie Curie UPMC Paris 06, Paris 75013, France
    Nat Genet 41:283-5. 2009
  4. ncbi Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Julius Maximilians University, Wurzburg, Germany
    Pharm Res 24:1227-51. 2007
  5. ncbi Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
  6. ncbi Correlation of low SLC22A18 expression with poor prognosis in patients with glioma
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, 280 Mo He Road, Bao Shan District, Shanghai 201900, China
    J Clin Neurosci 19:95-8. 2012
  7. pmc Discovery of the ergothioneine transporter
    Dirk Gründemann
    Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 102:5256-61. 2005
  8. ncbi Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Biol Chem 273:20378-82. 1998
  9. ncbi Carnitine transporter defect diagnosed by newborn screening with electrospray tandem mass spectrometry
    B Wilcken
    New South Wales Newborn Screening and Biochemical Genetics Services, The New Children's Hospital, Westmead, Sydney, Australia
    J Pediatr 138:581-4. 2001
  10. pmc Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstr 3A, 48149 Munster, Germany
    Am J Pathol 176:1169-80. 2010

Research Grants

Detail Information

Publications269 found, 100 shown here

  1. ncbi Carnitine transport by organic cation transporters and systemic carnitine deficiency
    K Lahjouji
    Division of Medical Genetics, , 3175 Cote Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada
    Mol Genet Metab 73:287-97. 2001
    ..This knowledge will also help in designing new drugs that regulate carnitine transport activity...
  2. ncbi Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity
    Hiromu Katsuda
    Department of Medicinal Informatics, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Biol Pharm Bull 33:1867-71. 2010
    ..From these results, cimetidine clearly inhibits nephrotoxicity induced by cisplatin without any influence on the antitumor activity of cisplatin on osteosarcoma in vitro and in vivo...
  3. ncbi Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    David Alexandre Tregouet
    Institut National de la Santé Et de la Recherche Médicale INSERM Unité Mixte de Recherche UMR_S 525, Université Pierre et Marie Curie UPMC Paris 06, Paris 75013, France
    Nat Genet 41:283-5. 2009
    ..This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits...
  4. ncbi Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Julius Maximilians University, Wurzburg, Germany
    Pharm Res 24:1227-51. 2007
    ..Transport studies with expressed OCTs will help to optimize pharmacokinetics during development of new drugs...
  5. ncbi Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    Nature 417:447-52. 2002
    ..Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution...
  6. ncbi Correlation of low SLC22A18 expression with poor prognosis in patients with glioma
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, 280 Mo He Road, Bao Shan District, Shanghai 201900, China
    J Clin Neurosci 19:95-8. 2012
    ..This study suggests that SLC22A18 functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease...
  7. pmc Discovery of the ergothioneine transporter
    Dirk Gründemann
    Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 102:5256-61. 2005
    ..Moreover, prominent expression of ETT in monocytes and SLC22A4 polymorphism associations suggest a protective role of ET in chronic inflammatory disorders...
  8. ncbi Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Biol Chem 273:20378-82. 1998
    ....
  9. ncbi Carnitine transporter defect diagnosed by newborn screening with electrospray tandem mass spectrometry
    B Wilcken
    New South Wales Newborn Screening and Biochemical Genetics Services, The New Children's Hospital, Westmead, Sydney, Australia
    J Pediatr 138:581-4. 2001
    ..Two of 4 babies subsequently diagnosed clinically with the carnitine transporter defect had a free carnitine level in the neonatal blood sample low enough to be detected by screening...
  10. pmc Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstr 3A, 48149 Munster, Germany
    Am J Pathol 176:1169-80. 2010
    ..These findings are very important to establish chemotherapeutical protocols aimed to maximize the antineoplastic effect of cisplatin while reducing the risk of toxicities...
  11. ncbi Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    J Nezu
    Chugai Research Institute for Molecular Medicine, Ibaraki, Japan
    Nat Genet 21:91-4. 1999
    ..In an affected individual belonging to a third family, we found a homozygous splice-site mutation also resulting in a premature stop codon. These mutations provide the first evidence that loss of OCTN2 function causes SCD...
  12. ncbi The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations
    Hiroshi Omote
    Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    Trends Pharmacol Sci 27:587-93. 2006
    ..Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body...
  13. ncbi The SLC22 drug transporter family
    Hermann Koepsell
    Institute of Anatomy and Cell Biology, Bayerische Maximilians Universität Würzburg, Koellikerstr 6, 97070, Wurzburg, Germany
    Pflugers Arch 447:666-76. 2004
    ..Defect mutations of transporters of the SLC22 family may cause specific diseases such as "primary systemic carnitine deficiency" or "idiopathic renal hypouricemia" or change drug absorption or excretion...
  14. pmc A human transporter protein that mediates the final excretion step for toxic organic cations
    Masato Otsuka
    Advanced Science Research Center, Okayama University, Dentistry and Pharmaceutical Sciences, Japan
    Proc Natl Acad Sci U S A 102:17923-8. 2005
    ..Thus, MATE1 appears to be the long searched for polyspecific OC exporter that directly transports toxic OCs into urine and bile...
  15. pmc Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
    Gloria Schlegel
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    BMC Vet Res 8:28. 2012
    ..Dairy cows are typically in a negative energy balance during early lactation. We investigated the hypothesis that genes of carnitine synthesis and uptake in dairy cows are enhanced during early lactation...
  16. ncbi Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    FEBS Lett 419:107-11. 1997
    ..It may play a role in the renal excretion of xenobiotics and their metabolites...
  17. ncbi Expression patterns of the organic cation/carnitine transporter family in adult murine brain
    Anne Marie Lamhonwah
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, University of Toronto, Toronto, Ont, Canada M5G 1X8
    Brain Dev 30:31-42. 2008
    ..Organic cation/carnitine transporters transport carnitine, drugs, and xenobiotics (e.g. choline, acetylcarnitine, betaine, valproic acid), and are expressed in muscle, heart, blood vessels, kidney, gut, etc...
  18. pmc Drug uptake systems in liver and kidney: a historic perspective
    B Hagenbuch
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA
    Clin Pharmacol Ther 87:39-47. 2010
    ....
  19. ncbi cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    X Wu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 246:589-95. 1998
    ..Several organic cations, including the neurotoxins 1-methyl-4-phenylpyridinium, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and methamphetamine, compete for the OCTN2-mediated transport process...
  20. pmc Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn's disease
    D Taubert
    Gut 54:1505-6. 2005
  21. ncbi PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Exp Biol Med (Maywood) 233:356-65. 2008
    ..It also shows that PPAR alpha mediates changes of whole-body carnitine homeostasis in mice by upregulation of carnitine transporters and enzymes involved in carnitine synthesis...
  22. ncbi Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis
    Chao Xuan
    Medical College of Nankai University, No 94, the Weijin Road, Tianjin, 300071, People s Republic of China
    Int J Colorectal Dis 27:11-9. 2012
    ..The present study aimed at investigating the associations...
  23. ncbi Molecular and cellular physiology of renal organic cation and anion transport
    Stephen H Wright
    Dept of Physiology, College of Medicine, Univ of Arizona, Tucson, AZ 85724, USA
    Physiol Rev 84:987-1049. 2004
    ....
  24. pmc Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency
    Cristina Amat di San Filippo
    Department of Pediatrics and Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Biochim Biophys Acta 1812:312-20. 2011
    ..Glycosylation does not affect maturation of OCTN2 transporters to the plasma membrane, but the 3 asparagines that are normally glycosylated are located in a region important for substrate recognition and turnover rate...
  25. ncbi Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease
    Umesh Babusukumar
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 101:1354-61. 2006
    ..We performed a comprehensive analysis of OCTN variants in an independent, exclusively pediatric onset CD cohort and examined the genotype/phenotype correlations...
  26. ncbi Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    J Nutr Biochem 20:840-7. 2009
    ..It is concluded that nonproliferating species are also able to cover their increased demand for carnitine during fasting by an increased carnitine synthesis and uptake into cells...
  27. ncbi Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha
    Tomoji Maeda
    Department of Membrane Transport and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
    Biol Pharm Bull 31:1230-6. 2008
    ..In conclusion, our results indicate that the nuclear receptor PPARalpha directly up-regulates the expression of rOctn2 and increases the hepatic uptake of carnitine via rOctn2...
  28. ncbi Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 640:143-9. 2010
    ..The progressive increase in cardiotoxicity enzymatic indices and the decrease in H-FABP and OCTN2 expression may point to the possible contribution of H-FABP and OCTN2 as a mechanism during development of doxorubicin cardiotoxicity...
  29. ncbi Mutational analysis of idiopathic renal hypouricemia in Korea
    Hae Il Cheong
    Department of Pediatrics, Seoul National University Children s Hospital, Seoul, Korea
    Pediatr Nephrol 20:886-90. 2005
    ..This is the first study of SLC22A12 mutations in a country other than Japan. W258X was found to be the predominant SLC22A12 mutation in Korean renal hypouricemia patients, as has been reported in Japan...
  30. pmc Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
    J Transl Med 9:156. 2011
    ..The aim of this study was to investigate the relationship between SLC22A18 downregulation, promoter methylation and the development and progression of human glioma...
  31. ncbi Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
    Anne T Nies
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Hepatology 50:1227-40. 2009
    ..0001), and four variants in OCT3 (rs2292334, rs2048327, rs1810126, rs3088442) were associated with reduced OCT3 mRNA levels (P = 0.03)...
  32. ncbi Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron
    Gaiping Wen
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle Saale, Germany
    Biochem Pharmacol 79:768-76. 2010
    ..In conclusion, the present study shows that mouse OCTN2 is a direct target gene of PPARalpha and that transcriptional upregulation of OCTN2 by PPARalpha is likely mediated via PPRE1 in its first intron...
  33. ncbi Molecular and functional characterization of organic cation/carnitine transporter family in mice
    I Tamai
    Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Biol Chem 275:40064-72. 2000
    ....
  34. pmc Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA
    Pharmacogenet Genomics 20:687-99. 2010
    ....
  35. ncbi Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
    David L Bourdet
    Division of Drug Delivery and Disposition, School of Pharmacy, Kerr Hall, CB 7360, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    J Pharmacol Exp Ther 315:1288-97. 2005
    ..Famotidine seems to be one of the most potent inhibitors of hOCT3 yet identified...
  36. ncbi Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone
    Takashi Iwanaga
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba 278 8510, Japan
    Drug Metab Dispos 33:1791-5. 2005
    ..These results indicate that URAT1 is involved in renal reabsorption of oxypurinol, and the increment of renal clearance of oxypurinol upon concomitant administration of benzbromarone could be due to drug interaction at URAT1...
  37. ncbi Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1
    Yukio Kato
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, 920 1192, Japan
    Pharm Res 27:832-40. 2010
    ..Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1...
  38. ncbi Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane
    Lorena Pochini
    Department of Cell Biology, University of Calabria, Via P Bucci 4c 87036 Arcavacata di Rende, Italy
    Biochim Biophys Acta 1661:78-86. 2004
    ..The reconstituted carnitine transporter corresponds, very probably, to the OCTN2 protein...
  39. pmc Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)
    H Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Br J Pharmacol 159:898-908. 2010
    ..As decreased drug accumulation is a key mechanism of platinum resistance, SLCs may also contribute to the development of resistance. Here, we define the role of hSLC22A2 (OCT2) in the cellular uptake of platinum compounds...
  40. ncbi Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes
    Lorena Pochini
    Department of Cell Biology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, CS, Italy
    Chem Biol Interact 179:394-401. 2009
    ..The pharmacological compound was not transported by the reconstituted transporter. The possible in vivo implications of the interaction of omeprazole with the transporter are discussed...
  41. pmc Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity
    K K Filipski
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 86:396-402. 2009
    ....
  42. pmc Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study
    Matthijs L Becker
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:745-9. 2009
    ..We studied the effect of single nucleotide polymorphisms (SNPs) in the SLC47A1 gene on the A1C-lowering effect of metformin...
  43. ncbi Human vascular smooth muscle cells express a urate transporter
    Karen L Price
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 17:1791-5. 2006
    ..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease...
  44. ncbi Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism
    Masahito Ogasawara
    Division of Pharmacology, Department of Integrated Basic Medical Science, Ehime University School of Medicine, Toon, Japan
    J Pharmacol Sci 101:24-30. 2006
    ....
  45. ncbi The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease
    Lorena Pochini
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
    Biochim Biophys Acta 1818:559-65. 2012
    ..These data identify a new transport role for OCTN1 and raise the possibility that its involvement in the non-neuronal acetylcholine system may be relevant to the pathogenesis of Crohn's disease...
  46. pmc Organic cation transporters are determinants of oxaliplatin cytotoxicity
    Shuzhong Zhang
    Department of Biopharmaceutical Sciences, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94158, USA
    Cancer Res 66:8847-57. 2006
    ..The development of new anticancer drugs, specifically targeted to OCTs, represents a novel strategy for targeted drug therapy. The results of the present structure-activity studies indicate specific tactics for realizing this goal...
  47. ncbi Gene expression and regulation of drug transporters in the intestine and kidney
    Tomohiro Terada
    Department of Pharmacy, Kyoto University Hospital, Kyoto 606 8507, Japan
    Biochem Pharmacol 73:440-9. 2007
    ..The purpose of this research updates is to review the recent progress in the study of the gene expression and regulation of intestinal and renal drug transporters...
  48. ncbi OCTN3 is a mammalian peroxisomal membrane carnitine transporter
    Anne Marie Lamhonwah
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Biochem Biophys Res Commun 338:1966-72. 2005
    ..This Octn3 localization is in keeping with the essential role of carnitine in peroxisomal lipid metabolism...
  49. ncbi Molecular enzymology of carnitine transfer and transport
    R R Ramsay
    Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK
    Biochim Biophys Acta 1546:21-43. 2001
    ..The kinetic and chemical mechanisms are also discussed in relation to the different inhibitors under study for their potential to control diseases of lipid metabolism...
  50. ncbi Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli
    Lorena Pochini
    Department of Cell Biology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy
    Biochem J 439:227-33. 2011
    ..77 mM was calculated. Acetylcholine and γ-butyrobetaine behaved as competitive inhibitors of TEA (tetraethylammonium) transport with K(i) values of 0.44 and 0.63 mM respectively...
  51. ncbi A founder mutation (R254X) of SLC22A5 (OCTN2) in Chinese primary carnitine deficiency patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Hum Mutat 20:232. 2002
    ..Other previously reported mutations found in the Japanese population were also screening in 250 control samples but no carrier was identified, indicating that they were either very rare or not present in Southern Chinese...
  52. ncbi Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: the mouse carnitine transporter OCTN3
    Mariafrancesca Scalise
    Department of Cell Biology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy
    Biochem Biophys Res Commun 422:59-63. 2012
    ..3)H]carnitine transport was inhibited by carnitine analogues and some Cys and NH(2) reagents. This paper represents the first outcome in over-expressing, in active form, the third member of the OCTN sub-family, mOCTN3, in E. coli...
  53. ncbi Role of organic cation transporters in drug-induced toxicity
    Giuliano Ciarimboli
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstr 3A, 48149 Munster, Germany
    Expert Opin Drug Metab Toxicol 7:159-74. 2011
    ..Consequently, drug interactions with these transporters can result in specific toxicity...
  54. ncbi Acute administration of cefepime lowers L-carnitine concentrations in early lactation stage rat milk
    Binbing Ling
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, S7N 5C9 Canada
    J Nutr 138:1317-22. 2008
    ....
  55. ncbi A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)
    Anne Marie Lamhonwah
    Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, Ont, Canada M5G 1X8
    Biochem Biophys Res Commun 301:98-101. 2003
    ..Its functional properties and inferred chromosomal location implicate it for involvement in Crohn's disease...
  56. ncbi Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    A E Busch
    Institut fur Physiologie, 72076 Tubingen, Germany
    Mol Pharmacol 54:342-52. 1998
    ..However, concentrations of amantadine that are effective for the treatment of Parkinson's disease may increase the interstitial concentrations of dopamine and other aminergic neurotransmitters by competitive inhibition of hOCT2...
  57. ncbi Interactions of urate transporter URAT1 in human kidney with uricosuric drugs
    Ho Jung Shin
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 16:156-62. 2011
    ..In this study the pharmacological characteristics and clinical implications of URAT1 were elucidated...
  58. pmc Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2
    Yasuto Kido
    Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94143, United States
    J Med Chem 54:4548-58. 2011
    ..Two compounds showed different kinetics of interaction with the common polymorphism OCT2-A270S, suggesting a role of genetics in modulating renal DDIs...
  59. ncbi Fasting and caloric restriction increases mRNA concentrations of novel organic cation transporter-2 and carnitine concentrations in rat tissues
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Nutr Metab 52:58-67. 2008
    ..In this study, we tested the hypothesis that fasting and caloric restriction, conditions under which PPARalpha activation also occurs, cause similar effects...
  60. ncbi The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
    Fusako Komoda
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pediatr Nephrol 19:728-33. 2004
    ..The present study demonstrates that homozygous W258X mutation is the predominant genetic cause of idiopathic renal hypouricemia in Japanese patients...
  61. ncbi Control of renal uric acid excretion and gout
    Atsuo Taniguchi
    Institute of Rneumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Curr Opin Rheumatol 20:192-7. 2008
    ..This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion...
  62. pmc Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
    Martina Hayer-Zillgen
    Institute of Pharmacology and Toxicology, University of Bonn, Reuterstr 2 b, D 53113 Bonn, Germany
    Br J Pharmacol 136:829-36. 2002
    ....
  63. ncbi Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    Kimiyoshi Ichida
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:164-73. 2004
    ..The findings indicate that SLC22A12 was responsible for most renal hypouricemia and that URAT1 is the primary reabsorptive urate transporter, targeted by pyrazinamide, benzbromarone, and probenecid in vivo...
  64. ncbi Two male siblings with hereditary renal hypouricemia and exercise-induced ARF
    Motoko Tanaka
    Department of Nephrology, Akebono Clinic, Kumamoto, Japan
    Am J Kidney Dis 42:1287-92. 2003
    ..This is the first report of the 2 male siblings of familial renal hypouricemia complicated with exercise-induced ARF, with definite demonstration of genetic abnormality in the responsible gene (URAT1)...
  65. ncbi Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
    Masayo Aoki
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 295:F165-70. 2008
    ..These results indicate that kidney-specific expression of human OCT2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1...
  66. ncbi Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer
    Sachiko Yokoo
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Drug Metab Dispos 36:2299-306. 2008
    ..In conclusion, the hOCT3-mediated uptake of oxaliplatin into the cancers was suggested to be important for its cytotoxicity, and hOCT3 expression may be a marker for cancer chemotherapy including oxaliplatin...
  67. ncbi Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
    ..Furthermore, the present results also indicate that an increased carnitine biosynthesis also contributes to the clofibrate-induced increase in hepatic carnitine concentration...
  68. ncbi Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    Naohiko Anzai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181 8611 Tokyo, Japan
    J Biol Chem 283:26834-8. 2008
    ....
  69. ncbi Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants
    Tomoe Fujita
    Department of Biopharmaceutical Sciences, University of California San Francisco, USA
    J Pharm Sci 95:25-36. 2006
    ..A variety of structurally diverse compounds have been shown to interact with OCT2, including endogenous compounds, drugs, and dietary supplements...
  70. ncbi Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria
    Anne Marie Lamhonwah
    Division of Neurology, Department of Pediatrics, University of Toronto, Ont, Canada
    Biochem Biophys Res Commun 345:1315-25. 2006
    ..This suggests an important yet different role for OCTN1 from other OCTN family members in intracellular carnitine homeostasis...
  71. ncbi Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin
    Masahiro Tsuda
    Department of Pharmacy, Kyoto University Hospital, Japan
    Mol Pharmacol 75:1280-6. 2009
    ..This is the first report to demonstrate an essential role of MATE1 in systemic clearance of metformin...
  72. ncbi Diagnoses of newborns and mothers with carnitine uptake defects through newborn screening
    Ni Chung Lee
    Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan
    Mol Genet Metab 100:46-50. 2010
    ..Detection of CUD in mothers may prevent them from developing dilated cardiomyopathy...
  73. pmc Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Hum Mol Genet 20:4056-68. 2011
    ..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants...
  74. ncbi PPARalpha agonists up-regulate organic cation transporters in rat liver cells
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Biochem Biophys Res Commun 350:704-8. 2006
    ..We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis...
  75. pmc Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate
    Promsuk Jutabha
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo 181 8611, Japan
    J Biol Chem 285:35123-32. 2010
    ..Our findings will complete a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4...
  76. ncbi L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2
    Karim Lahjouji
    Division of Medical Genetics, Hopital Sainte Justine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Am J Physiol Cell Physiol 287:C263-9. 2004
    ..The reported properties of OCTN2 resemble those observed for l-carnitine uptake in placental BBM vesicles, suggesting that OCTN2 may mediate most maternofetal carnitine transport in humans...
  77. ncbi Carnitine membrane transporter deficiency: a long-term follow up and OCTN2 mutation in the first documented case of primary carnitine deficiency
    Stephen D Cederbaum
    Department of Psychiatry, UCLA, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Mol Genet Metab 77:195-201. 2002
    ..The 13/19bp insertions were found in both parents, predominantly in cis with the deletion, and rarely seen with normal alleles from either parents or controls...
  78. ncbi The solute carrier 44A1 is a mitochondrial protein and mediates choline transport
    Vera Michel
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    FASEB J 23:2749-58. 2009
    ..SLC44A1 mRNA and protein expression were down-regulated during choline deficiency. These data clearly establish SLC44A1 as an important mediator of choline transport across both the plasma membrane and the mitochondrial membrane...
  79. pmc OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBER Fisiopatologia de la Obesidad y Nutricion, Spain
    Diabetes 60:168-76. 2011
    ..We investigated the gene expression and protein levels of OCT-1 and OCT-2 in adipose tissue and during adipogenesis and evaluated their possible role in metformin action on adipocytes...
  80. pmc Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples
    C Schwienbacher
    Department of Experimental and Diagnostic Medicine, Section of Microbiology, and Interdepartment Center for Biotechnology, University of Ferrara, 44100, Ferrara, Italy
    Proc Natl Acad Sci U S A 95:3873-8. 1998
    ..These results indicate that BWR1A may play a role in tumorigenesis...
  81. ncbi Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer
    E Gallagher
    School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, Belfield, Dublin 4, Ireland
    Genomics 88:12-7. 2006
    ..This study reports the imprinting status of SLC22A18AS in adult tissue, and shows that GOI affects both the sense, and antisense transcripts at this locus in human breast tissue...
  82. ncbi Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)
    Atsushi Yonezawa
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 319:879-86. 2006
    ..These transporters could play predominant roles in the tissue distribution and anticancer effects and/or adverse effects of platinum agent-based chemotherapy...
  83. ncbi Cloning and characterization of two human polyspecific organic cation transporters
    V Gorboulev
    Anatomisches Institut der Bayerischen Julius Maximilians Universität, Wurzburg, Germany
    DNA Cell Biol 16:871-81. 1997
    ..Cation transport in distal tubules is indicated for the first time. Here hOCT2 mediates the first step in cation reabsorption. hOCT1 may participate in hepatic excretion of organic cations...
  84. ncbi Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2
    R Ohashi
    Faculty of Pharmaceutical Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Mol Pharmacol 59:358-66. 2001
    ..The results are consistent with the physiological coupling of carnitine reabsorption with the secretion of organic cations...
  85. ncbi Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients
    Maurizio Martini
    Istituto di Anatomia Patologica, Universita Cattolica del Sacro Cuore, Roma, Italy
    Inflamm Bowel Dis 18:439-48. 2012
    ..We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP)...
  86. ncbi Characterization of organic cation/carnitine transporter family in human sperm
    Wanli Xuan
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Ont, M5G 1X8, Toronto, Canada
    Biochem Biophys Res Commun 306:121-8. 2003
    ..7+/-20.5 pmol/min/mg protein; n=18). Identification of individuals with defective sperm carnitine transport may provide potentially treatable etiologies of male infertility, responsive to L-carnitine supplementation...
  87. ncbi Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation
    Takeshi Uemura
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    J Biol Chem 280:9646-52. 2005
    ..Sorting of TPO1 from the endoplasmic reticulum to the plasma membrane was enhanced through phosphorylation at Ser342 by cAMP-dependent protein kinases 1 and 2...
  88. ncbi beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
    M E Ganapathy
    Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 275:1699-707. 2000
    ....
  89. pmc L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation
    G Fortin
    Department of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada
    Clin Exp Immunol 156:161-71. 2009
    ..LCAR therapy may therefore represent a novel alternative therapeutic strategy and highlights the role of diet in CD...
  90. ncbi Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
    Satish A Eraly
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0693, USA
    Physiol Genomics 18:12-24. 2004
    ..This might reflect a requirement for redundancy or broader substrate specificity in vertebrates (compared to invertebrates), due to their greater physiological complexity and thus potentially broader exposure to organic ions...
  91. ncbi OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2
    Satoshi Maekawa
    Department of Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Biochim Biophys Acta 1773:1000-6. 2007
    ..These results demonstrate that the biochemical and functional characteristics of OCTN2VT are distinct from OCTN2 due to the insertion of 24 amino acids in the first extracellular loop...
  92. ncbi Over-expression in E. coli and purification of the human OCTN1 transport protein
    Michele Galluccio
    Department of Cell Biology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende CS, Italy
    Protein Expr Purif 68:215-20. 2009
    ..The homogeneously purified hOCTN1 was eluted with a buffer containing 50 mM imidazole, 0.1% Triton X-100 and 50 mM 2-mercaptoethanol. A yield of about 3mg purified protein per liter of cell culture was obtained...
  93. ncbi Pharmacological rescue of carnitine transport in primary carnitine deficiency
    Cristina Amat di San Filippo
    Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA
    Hum Mutat 27:513-23. 2006
    ..These results indicate that OCTN2 mutations can affect carnitine transport by impairing maturation of transporters to the plasma membrane. Pharmacological therapy can be effective in partially restoring activity of mutant transporters...
  94. ncbi Functional reconstitution into liposomes and characterization of the carnitine transporter from rat liver microsomes
    Annamaria Tonazzi
    National Research Council CNR Institute of Biomembranes and Bioenergetics IBBE, Via Amendola 165 A 70126 Bari, Italy
    Biochim Biophys Acta 1758:124-31. 2006
    ..Optimal activity was found at pH 8.0. The Km for carnitine on the external side of the transporter was 10.9+/-0.16 mM. The activation energy of the carnitine transport derived by Arrhenius plot was 16.1 kJ/mol...
  95. ncbi Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa
    Daisuke Kobayashi
    Division of Pharmaceutical Sciences, Department of Molecular Biopharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Reproduction 134:651-8. 2007
    ..We conclude that both Na(+)-dependent and -independent carnitine transporters, OCTN2 and OCTN3, mediate the supply of carnitine and acetylcarnitine to epididymal spermatozoa in mice...
  96. pmc Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease
    Judit Bene
    Department of Medical Genetics and Child Development, University of Pecs, H 7624 Pecs, Szigeti 12, Hungary
    World J Gastroenterol 12:5550-3. 2006
    ..To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn's disease (CD)...
  97. ncbi Identification and expression of a mouse muscle-specific CTL1 gene
    Zongfei Yuan
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Gene 341:305-12. 2004
    ....
  98. ncbi Molecular physiology and the four-component model of renal urate transport
    David B Mount
    Curr Opin Nephrol Hypertens 14:460-3. 2005
  99. pmc Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability
    Youcai Zhang
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 124:251-60. 2011
    ..Taken together, the current data suggest that Oatp1a1 does not mediate the hepatic uptake of DCA or TDCA, but lack of Oatp1a1 increases intestinal permeability and thus enhances the absorption of DCA in mice...
  100. ncbi Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid peroxidation and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2
    M Mazzini
    Cardiac Electrophysiology Section and Cardiovascular Medicine Section, Boston University Medical Center, Boston, MA 02118, USA
    Cardiology 120:52-8. 2011
    ..The disease is associated with cardiomyopathy and arrhythmias, but the mechanism is unknown. We hypothesized that carnitine deficiency results in increased myocardial oxidative stress...
  101. ncbi Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine
    Sumito Ito
    Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 333:341-50. 2010
    ..Taken together, PYR can be used as a potent probe inhibitor of human MATE transporters...

Research Grants25

  1. Role of MRP2 and MRP4 in renal organic anion excretion
    RYAN PELIS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. RENAL TRANSPORT OF ORGANIC CHELATORS OF HEAVY METALS
    Stephen Wright; Fiscal Year: 2004
    ..The proposed studies will result in a new, general model of the cellular strategy for secretion of a diverse array of xenobiotic OAs, and a more specific understanding of the action of heavy metal chelators on renal cells. ..
  3. Molecular Organization or Renal Organic Anion Transport
    Stephen H Wright; Fiscal Year: 2010
    ..abstract_text> ..
  4. MOLECULAR ORGANIZATION OF RENAL ORGANIC CATION TRANSPORT
    Stephen Wright; Fiscal Year: 2008
    ..These studies will be essential for development of models that accurately predict and, ideally, preempt unwanted interactions of cationic drugs in both the kidney and liver. ..
  5. AMPHETAMINE, INSULIN AND THE DA TRANSPORTER IN VIVO
    Lynette Daws; Fiscal Year: 2005
    ..In turn, these studies may help to illuminate the neural mechanisms underlying the high co-morbidity of eating disorders and drug abuse. ..
  6. PLACENTAL CARNITINE: ROLE IN FETAL DEVELOPMENT
    Prem Shekhawat; Fiscal Year: 2008
    ..abstract_text> ..
  7. ETIOLOGY OF NEPHROPATHY AND HYPERTENSION IN AASK PATIENT
    Michael Lipkowitz; Fiscal Year: 2004
    ....
  8. Proteomic Predictors Of AASK Renal Disease Progression
    Michael Lipkowitz; Fiscal Year: 2005
    ..We also hypothesize that LAD will detect patterns of baseline values in the AASK data set that will predict AASK outcomes; we will re-examine the AASK data set with LAD for this aim. ..
  9. ISLET DYSREGULATION IN INFANTS
    Charles Stanley; Fiscal Year: 2008
    ..The results of this research will provide essential information for improving the diagnosis and treatment of HI children and for understanding the basis of insulin regulation in normal humans. ..
  10. Ped Endocrine Career Development in Diabetes Research
    Charles Stanley; Fiscal Year: 2007
    ..The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year. ..
  11. AMINO ACID TRANSPORTER B: PHARMACOLOGY & THERAPEUTIC USE
    Malliga Ganapathy; Fiscal Year: 2006
    ....
  12. Cell Signaling, PXR Phosphorylation & Drug Disposition
    Jeffrey Staudinger; Fiscal Year: 2009
    ..These studies will provide additional insight into the regulation of drug disposition and drug-drug interaction. ..
  13. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  14. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  15. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004
    ....
  16. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  17. GENETIC STUDIES IN INFLAMMATORY BOWEL DISEASE
    JUDY CHO; Fiscal Year: 2002
    ..Strategies for fine localization of loci, including fine-mapping by linkage disequilibrium, are proposed. alternative approaches to gene identification and mutation detection are discussed. ..
  18. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  19. Regulation of Renal Xenobiotic Transport by Estrogens
    Stephen Wright; Fiscal Year: 2006
    ....
  20. MOLECULAR BASIS OF A NEW FORM OF HYPERINSULINISM
    CHARLES ALFRED STANLEY; Fiscal Year: 2010
    ....
  21. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  22. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..
  23. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  24. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  25. ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEY
    Gerhard Giebisch; Fiscal Year: 2003
    ..Patch-clamp and whole-cell current measurements will be carried out in native tubules and in an oocyte expression system, and tubule perfusion studies in ROMK knock-out mice. ..