- Identification of c-MYC as a target of the APC pathway
T C He
Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
Science 281:1509-12. 1998
..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers...
- Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
P J Morin
Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
Science 275:1787-90. 1997
..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
- Cryopyrin activates the inflammasome in response to toxins and ATP
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006
..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
- Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
Science 275:1784-7. 1997
..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
- Wnt signaling and cancer
Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
Genes Dev 14:1837-51. 2000
- The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Mol Cell 10:417-26. 2002
..Thus, the inflammasome constitutes an important arm of the innate immunity...
- Organizing the cell cortex: the role of ERM proteins
Richard G Fehon
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
Nat Rev Mol Cell Biol 11:276-87. 2010
..Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions...
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009
..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
- The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 96:5522-7. 1999
..Increased beta-catenin levels may thus promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle...
- Functional interaction of beta-catenin with the transcription factor LEF-1
Max Delbruck Centre for Molecular Medicine, Berlin, Germany
Nature 382:638-42. 1996
..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
- Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Development 128:1253-64. 2001
..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
- beta-catenin is a target for the ubiquitin-proteasome pathway
Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
EMBO J 16:3797-804. 1997
..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
Vijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010
..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
- Rho GTPases and their effector proteins
A L Bishop
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
Biochem J 348:241-55. 2000
..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
- Taking cell-matrix adhesions to the third dimension
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Science 294:1708-12. 2001
..These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms...
- Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
Thomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Annu Rev Pharmacol Toxicol 47:89-116. 2007
..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
- FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
Donna J Webb
Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
Nat Cell Biol 6:154-61. 2004
- Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
Development 126:4557-68. 1999
..Furthermore, our findings unveil the importance of activated LEF/TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place...
- Nrf2-Keap1 defines a physiologically important stress response mechanism
Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
Trends Mol Med 10:549-57. 2004
..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
- The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 97:221-31. 1999
..Therefore, N-WASP and the Arp2/3 complex comprise a core mechanism that directly connects signal transduction pathways to the stimulation of actin polymerization...
- Systematic genetic analysis with ordered arrays of yeast deletion mutants
A H Tong
Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
Science 294:2364-8. 2001
..Systematic application of this approach should produce a global map of gene function...
- The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Daniel A Muruve
Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
Nature 452:103-7. 2008
..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity...
- beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
Cell 105:533-45. 2001
..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
- BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
Brian J Peter
Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Science 303:495-9. 2004
..From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module...
- Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
Nature 398:422-6. 1999
..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
- Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biol 143:1947-60. 1998
..Overexpression of Cyk2p also blocks cytokinesis, most likely due to a loss of the septins from the bud neck, indicating that Cyk2p may also play a role in regulating the localization of the septins...
- Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
EMBO J 18:5931-42. 1999
..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
- XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
Department of Immunology University Hospital, Utrecht The Netherlands
Cell 86:391-9. 1996
..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
- The Nalp3 inflammasome is essential for the development of silicosis
SUZANNE L CASSEL
Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 105:9035-40. 2008
..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
- Linking colorectal cancer to Wnt signaling
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Cell 103:311-20. 2000
- Bacterial cell division: assembly, maintenance and disassembly of the Z ring
David W Adams
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Nat Rev Microbiol 7:642-53. 2009
..In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly...
- Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
Proc Natl Acad Sci U S A 100:3299-304. 2003
..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
- The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
Nat Cell Biol 2:76-83. 2000
..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
- De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
Cell 95:605-14. 1998
..Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal leading to hair development and implicate aberrant beta-catenin activation in hair tumors...
- NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Immunity 20:319-25. 2004
..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
- Wnt signaling: a common theme in animal development
K M Cadigan
Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
Genes Dev 11:3286-305. 1997
- Assembly and architecture of precursor nodes during fission yeast cytokinesis
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
J Cell Biol 192:1005-21. 2011
..Collectively, our work characterizing the assembly and architecture of precursor nodes defines important steps and molecular players for contractile ring assembly...
- The immediate early gene arc/arg3.1: regulation, mechanisms, and function
Clive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
J Neurosci 28:11760-7. 2008
..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...
- A modular design for the clathrin- and actin-mediated endocytosis machinery
Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
Cell 123:305-20. 2005
- Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
Cell Host Microbe 8:471-83. 2010
..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
- Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
Proc Natl Acad Sci U S A 98:10356-61. 2001
- Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
EMBO J 17:1371-84. 1998
..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
- FtsZ ring structure associated with division in Escherichia coli
E F Bi
Department of Microbiology, University of Kansas Medical Center, Kansas City 66103
Nature 354:161-4. 1991
..The results suggest that FtsZ self-assembles into a ring structure at the future division site and may function as a cytoskeletal element. The formation of this ring may be the point at which division is regulated...
- Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Cell Biol 13:1124-31. 2011
..We also find that light-chain-bound Hip1R mediates actin engagement. These data thus provide a unifying explanation for the role of actin dynamics in coated-pit budding...
- MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA
Cell 126:147-62. 2006
..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated...
- A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum
R M Marion
Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
Mol Cell Biol 19:2212-9. 1999
..Furthermore, sedimentation analyses indicated that hStaufen-like protein associates with polysomes. These results are discussed in relation to the possible functions of the protein...
- Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
Science 280:596-9. 1998
..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
- The Arc of synaptic memory
Clive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
Exp Brain Res 200:125-40. 2010
..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
- Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
Eek Hoon Jho
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Mol Cell Biol 22:1172-83. 2002
..Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal...
- Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Cell 98:147-57. 1999
..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
- A metabolic sensor governing cell size in bacteria
Richard B Weart
Department of Biology, Washington University, St Louis, MO 63130, USA
Cell 130:335-47. 2007
..This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis...
- Requirement for beta-catenin in anterior-posterior axis formation in mice
Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
J Cell Biol 148:567-78. 2000
..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
- Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
P F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 14:359-75. 2009
..With the integrated replication effort, we present a specific hypothesis for further studies...
- Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 282:2079-81. 1998
..Thus, alpha-DG is a cellular receptor for both LCMV and LFV...
- PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
T C He
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cell 99:335-45. 1999
..These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC...
- Assembly of centrosomal proteins and microtubule organization depends on PCM-1
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
J Cell Biol 159:255-66. 2002
- The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin
A K Gillingham
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO Rep 1:524-9. 2000
..When isolated from transfected cells the C-terminal domain of AKAP450 was associated with calmodulin, suggesting that this protein could contribute to centrosome assembly...
- Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Cell Biol 140:647-57. 1998
- Arc in synaptic plasticity: from gene to behavior
Gladstone Institute of Neurological Disease, San Francisco, CA, USA
Trends Neurosci 34:591-8. 2011
..We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions...
- FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling
The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
Neuron 61:359-72. 2009
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
Mihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009
..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
- The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
Department of Biochemistry, University of Washington School of Medicine, Seattle, 98195 7370, USA
Genes Dev 10:1443-54. 1996
..These studies provide a basis for understanding the interaction between Xgsk-3 and beta-catenin in the establishment of the dorsal-ventral axis in early Xenopus embryos...
- LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Nature 411:321-5. 2001
..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
- Association of the APC gene product with beta-catenin
Onyx Pharmaceuticals, Richmond, CA 94806
Science 262:1731-4. 1993
..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
- Paxillin: adapting to change
Michael C Brown
Dept of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Physiol Rev 84:1315-39. 2004
- Advances in understanding E. coli cell fission
Piet A J de Boer
Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, W213, 10900 Euclid Ave, Cleveland, OH 44106, USA
Curr Opin Microbiol 13:730-7. 2010
- Inflammasome recognition of influenza virus is essential for adaptive immune responses
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Exp Med 206:79-87. 2009
..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
- Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
PLoS Pathog 3:e111. 2007
..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions...
- STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown
Reyad A Elbarbary
Department of Biochemistry and Biophysics, School of Medicine and Dentistry
Genes Dev 27:1495-510. 2013
..We also show that a changing STAU1/PKR ratio contributes to myogenesis via effects on the 3' UTR IRAlus of mRNA encoding the microRNA-binding protein LIN28. ..
- SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
Cell 134:353-64. 2008
..The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions...
- Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 110:405-12. 2013
..We propose that STAU paralogs contribute to SMD by "greasing the wheels" of RNA-bound UPF1 so as to enhance its unwinding capacity per molecule of ATP hydrolyzed...
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nature 458:509-13. 2009
..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1...
- Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
Nature 355:696-702. 1992
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one
Harold P Erickson
Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
Microbiol Mol Biol Rev 74:504-28. 2010
..Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation...
- Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
Mol Biol Cell 6:1061-75. 1995
..The conformationally inaccessible C-terminal region included the F-actin binding site, suggesting that this activity is likewise regulated by masking...
- Mycobacterium tuberculosis prevents inflammasome activation
Sharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008
..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
- Arc regulates spine morphology and maintains network stability in vivo
Carol L Peebles
Gladstone Institute of Neurological Disease and the Keck Program in Striatal Physiology, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:18173-8. 2010
..Supporting this, loss of Arc in vivo leads to a significant decrease in the proportion of thin spines and an epileptic-like network hyperexcitability...
- Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces
Molecular Biotechnology, Gorlaeus Laboratories, Leiden University, Leiden 2300RA, The Netherlands
Genes Dev 25:89-99. 2011
- Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmus
Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, People s Republic of China
Mol Vis 14:733-8. 2008
..Recently, mutations in FRMD7 were found to be responsible for X-linked idiopathic infantile nystagmus . We investigated the role of the FRMD7 gene mutations in seven Chinese families with infantile nystagmus...
- A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large family
Department of Genetics, National Research Institute for Family Planning, Beijing, China
Mol Vis 14:56-60. 2008
..To identify the gene responsible for causing an X-linked idiopathic congenital nystagmus (XLICN) in a six-generation Chinese family...
- Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
Christopher L Case
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Infect Immun 77:1981-91. 2009
..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
- The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development
MRC Toxicology Unit, University of Leicester, Leicester, UK
Hum Mol Genet 19:342-51. 2010
..Taken together, our data suggest that FRMD7 is involved in multiple aspects of neuronal development, and have direct importance to further understanding the pathogenesis of IIN...
- The genetics of primary open-angle glaucoma: a review
R Rand Allingham
Duke University Eye Center, Duke University, Durham, NC 27710, USA
Exp Eye Res 88:837-44. 2009
..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
- Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
Erin McElvania TeKippe
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e12320. 2010
..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
- The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
Mol Cell 7:1267-78. 2001
..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
- EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Proc Natl Acad Sci U S A 105:13-9. 2008
- Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
Donna D Zhang
Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
Mol Cell Biol 23:8137-51. 2003
..We propose that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress...
- Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:175-81. 2004
..The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer...
- Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
Jason D Shepherd
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 52:475-84. 2006
..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
- Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nat Genet 38:1242-4. 2006
..We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability...
- Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons
C L Leung
Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Biol 147:1275-86. 1999
..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
- Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
J Neurosci 25:1761-8. 2005
..This is the first demonstration of network-selective translational events consequent to spatial behavior and suggests a role for immediate-early genes in circuit-specific, late-phase synaptic biology...
- Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
Steven W Flavell
Neurobiology Program, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 311:1008-12. 2006
..These findings define an activity-dependent transcriptional program that may control synapse number during development...
- APC binds to the novel protein EB1
L K Su
Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
Cancer Res 55:2972-7. 1995
..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
- Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Gulab S Zode
Howard Hughes Medical Institute, Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Invest 121:3542-53. 2011
..These results demonstrate that ER stress is linked to the pathogenesis of POAG and may be a target for treatment in human patients...
- Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check
Nam Ky Tonthat
Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
EMBO J 30:154-64. 2011
..Thus, the combined data reveal how SlmA derails Z-ring formation at the correct place and time to effect NO...
- Primary open-angle glaucoma genes
J H Fingert
Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Eye (Lond) 25:587-95. 2011
..Each of these different approaches to study glaucoma genetics is providing new insights into the pathogenesis of POAG...
- Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
F B Gertler
Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Cell 87:227-39. 1996
..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
- Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
J F Guzowski
Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
Nat Neurosci 2:1120-4. 1999
..Arc gene induction is thus specifically linked to neural encoding processes...
- Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
Neuron 59:70-83. 2008
..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD...
- Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
Yi Arial Zeng
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
Cell Stem Cell 6:568-77. 2010
..We conclude that Wnt proteins serve as rate-limiting self-renewal signals acting directly on mammary stem cells...