proto oncogene proteins c myb

Summary

Summary: Cellular DNA-binding proteins encoded by the myb gene (GENES, MYB). They are expressed in a wide variety of cells including thymocytes and lymphocytes, and regulate cell differentiation. Overexpression of myb is associated with autoimmune diseases and malignancies.

Top Publications

  1. ncbi MYB function in normal and cancer cells
    Robert G Ramsay
    Peter MacCallum Cancer Centre, St Andrew s Place, Melbourne, Victoria 3002, Australia
    Nat Rev Cancer 8:523-34. 2008
  2. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
  3. ncbi The ENHANCER OF TRY AND CPC1 gene acts redundantly with TRIPTYCHON and CAPRICE in trichome and root hair cell patterning in Arabidopsis
    Victor Kirik
    Botanical Institute, University of Koeln, Gyrhofstrasse, Cologne, Germany
    Dev Biol 268:506-13. 2004
  4. ncbi Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC
    T Wada
    Division I of Gene Expression and Regulation, National Institute for Basic Biology, Okazaki, 444, Japan
    Science 277:1113-6. 1997
  5. ncbi A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    M L Mucenski
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, Ohio
    Cell 65:677-89. 1991
  6. ncbi B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer
    Arturo Sala
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, WC1N 1EH London, UK
    Eur J Cancer 41:2479-84. 2005
  7. ncbi c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
  8. ncbi Critical functions for c-Myb at three checkpoints during thymocyte development
    Timothy P Bender
    The Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Nat Immunol 5:721-9. 2004
  9. ncbi A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nature 419:738-43. 2002
  10. pmc Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb
    Nikla Emambokus
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    EMBO J 22:4478-88. 2003

Research Grants

  1. Mutations and target genes in Adenoid Cystic Carcinoma
    Scott A Ness; Fiscal Year: 2013
  2. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
  3. Gene Regulation by Myb Proteins
    Joseph Lipsick; Fiscal Year: 2005
  4. STRUCTURE AND FUNCTION OF MYB ONCOGENE IN NEURONAL CELLS
    Richard Press; Fiscal Year: 1993
  5. ROLE OF C-MYB IN T-LYMPHOCYTES PROLIFERATION
    Bruno Calabretta; Fiscal Year: 1991
  6. Examing Oligonucleotide Effects on Gene Expression
    Alan Gewirtz; Fiscal Year: 2007
  7. Developing Nucleic Acid Therapeutics
    Alan Gewirtz; Fiscal Year: 2007
  8. HIV as a key regulator of c-MYB in human cells
    Robert Ramsay; Fiscal Year: 2004
  9. iCyt Reflection Cell Sorter
    TIMOTHY BENDER; Fiscal Year: 2007
  10. A QTL for fetal hemoglobin and F cells on chromosome 8q
    Swee Thein; Fiscal Year: 2003

Detail Information

Publications198 found, 100 shown here

  1. ncbi MYB function in normal and cancer cells
    Robert G Ramsay
    Peter MacCallum Cancer Centre, St Andrew s Place, Melbourne, Victoria 3002, Australia
    Nat Rev Cancer 8:523-34. 2008
    ....
  2. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
    ....
  3. ncbi The ENHANCER OF TRY AND CPC1 gene acts redundantly with TRIPTYCHON and CAPRICE in trichome and root hair cell patterning in Arabidopsis
    Victor Kirik
    Botanical Institute, University of Koeln, Gyrhofstrasse, Cologne, Germany
    Dev Biol 268:506-13. 2004
    ..These results suggest that ETC1, TRY, and CPC act in concert to repress the trichome cell fate in the shoot epidermis and the non-hair cell fate in the root epidermis...
  4. ncbi Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC
    T Wada
    Division I of Gene Expression and Regulation, National Institute for Basic Biology, Okazaki, 444, Japan
    Science 277:1113-6. 1997
    ..Transgenic plants overexpressing CPC had more root hairs and fewer trichomes than normal. Thus, the CPC gene determines the fate of epidermal cell differentiation in Arabidopsis...
  5. ncbi A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    M L Mucenski
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, Ohio
    Cell 65:677-89. 1991
    ..Additional hematopoietic lineages were similarly affected. These results are compatible with a role for c-myb in maintaining the proliferative state of hematopoietic progenitor cells...
  6. ncbi B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer
    Arturo Sala
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, WC1N 1EH London, UK
    Eur J Cancer 41:2479-84. 2005
    ..Here, we discuss how B-MYB could be implicated in tumourigenesis by regulating gene expression...
  7. ncbi c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
    ..Cell cycle analyses show that twice as many HSCs from c-Myb(M303V/M303V) animals are actively cycling. Thus c-Myb, through interaction with p300, controls the proliferation and differentiation of hematopoietic stem and progenitor cells...
  8. ncbi Critical functions for c-Myb at three checkpoints during thymocyte development
    Timothy P Bender
    The Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Nat Immunol 5:721-9. 2004
    ..Thus, c-Myb is essential at several stages during T cell development in the thymus...
  9. ncbi A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nature 419:738-43. 2002
    ..Thus, conserved domains in two highly related coactivators have contrasting roles in haematopoiesis...
  10. pmc Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb
    Nikla Emambokus
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    EMBO J 22:4478-88. 2003
    ..Overall, our results point to a complex involvement of c-Myb in the regulation of proliferation and commitment within the haemopoietic hierarchy...
  11. ncbi Loss of Drosophila Myb interrupts the progression of chromosome condensation
    J Robert Manak
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5342, USA
    Nat Cell Biol 9:581-7. 2007
    ....
  12. ncbi Xenopus A-myb is expressed during early spermatogenesis
    J P Sleeman
    Wellcome CRC Institute, Cambridge, UK
    Oncogene 8:1931-41. 1993
    ..These results suggest related roles for myb variants during the development of different stem cell-derived populations...
  13. ncbi A C-terminal Myb extension domain defines a novel family of double-strand telomeric DNA-binding proteins in Arabidopsis
    Zemfira N Karamysheva
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 279:47799-807. 2004
    ..Thus, Myb-ext is required for binding plant telomeric DNA and defines a novel class of proteins in Arabidopsis...
  14. pmc Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability
    J Robert Manak
    Department of Pathology, Stanford University School of Medicine, Room L216, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 99:7438-43. 2002
    ..Together these findings imply that Dm-Myb provides an essential nontranscriptional function during chromosomal replication...
  15. pmc CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis
    Julien Y Bertrand
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0380, USA
    Development 135:1853-62. 2008
    ..Together, these studies suggest that expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM, and provide the means to further dissect HSC generation and function in the early vertebrate embryo...
  16. ncbi Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1
    Yohta Fujita
    CREST Research Project of Japan Science and Technology Corporation JST, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Kyoto 606 8501, Japan
    Dev Cell 12:17-30. 2007
    ..Telophase centromere chromatin may be primed or licensed by the hMis18 complex and RbAp46/48 to recruit CENP-A through regulating the acetylation status in the centromere...
  17. ncbi c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development
    You Chin Lin
    Genomics Research Center, Academia Sinica Taipei, Taiwan
    Mol Biol Evol 25:2189-98. 2008
    ..Our findings suggest that c-Myb is an evolutionally conserved target of miR-150 and miR-150/c-Myb interaction is important for embryonic development and possibly oncogenesis...
  18. ncbi Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins
    Marek Sramko
    Center of Molecular Medicine, Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovakia
    J Biol Chem 281:40065-75. 2006
    ..Our findings demonstrate that SUMO-2/3 proteins conjugate to c-Myb and negatively regulate its activity in cells under stress...
  19. ncbi Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb
    K Ogata
    Graduate School of Integrated Science, Yokohama City University, Japan
    Nat Struct Biol 2:309-20. 1995
    ..On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA...
  20. ncbi Regulation of CAPRICE transcription by MYB proteins for root epidermis differentiation in Arabidopsis
    Yoshihiro Koshino-Kimura
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502 Japan
    Plant Cell Physiol 46:817-26. 2005
    ..We showed that WER also binds to the GL2 promoter region, indicating that WER directly regulates CPC and GL2 transcription by binding to their promoter regions...
  21. ncbi Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar
    Kazuhiro Ogata
    Department of Biochemistry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Opin Struct Biol 13:40-8. 2003
    ..g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms...
  22. ncbi FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
    A H Alm-Kristiansen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Oncogene 27:4644-56. 2008
    ..These results imply a novel molecular mechanism of regulation of c-Myb activity. We propose that c-Myb cooperates with FLASH in foci associated with active RNA polymerase II, leading to enhancement of Myb-dependent gene activation...
  23. ncbi Role of a positive regulator of root hair development, CAPRICE, in Arabidopsis root epidermal cell differentiation
    Takuji Wada
    Plant Science Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Development 129:5409-19. 2002
    ..We also show that the N terminus of bHLH protein interacts with CPC and is responsible for the GL2 expression. We propose a model in which CPC plays a key role in the fate-determination of hair-forming cells...
  24. ncbi Expression of mouse c-myb during embryonic development
    J Sitzmann
    Hans Spemann Laboratory Max Planck Institute for Immunobiology Stübeweg 51, Freiburg, Germany
    Oncogene 11:2273-9. 1995
    ..Our results suggest that the function of c-myb may not be restricted to hematopoietic cells...
  25. ncbi The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb
    A B Dash
    Northwestern University, Department of Biochemistry, Molecular Biology and Cell Biology, Evanston, Illinois 60208 3500, USA
    Genes Dev 10:1858-69. 1996
    ..Our results suggest that Myb is regulated by a novel mechanism in which intramolecular interactions and conformational changes control the intermolecular associations among Myb, p100, and the transcriptional apparatus...
  26. ncbi Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity
    Juraj Bies
    Department of Molecular Virology, Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 833 91 Bratislava, Slovakia
    J Biol Chem 277:8999-9009. 2002
    ..Thus, modification of c-Myb with SUMO-1 represents a novel mechanism through which the negative regulatory domain can exert its suppressing activity on c-Myb transactivation capacity...
  27. ncbi Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development
    Hiroshi Sakamoto
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Blood 108:896-903. 2006
    ....
  28. pmc Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage
    C Nicot
    Section of Animal Models and Retroviral Vaccines, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:7391-402. 2001
    ..Interestingly, an amino-terminal deletion form of p300 lacking the C/H1 and KIX domains and unable to bind RelA retained the ability to stimulate c-Myb transcription and prevented NF-kappaB-mediated repression...
  29. pmc Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M
    M Oelgeschlager
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    EMBO J 15:2771-80. 1996
    ..We suggest that CBP can bridge between c-Myb and NF-M, thus providing an explanation for the strong synergism between these two proteins...
  30. ncbi c-Myb is critical for B cell development and maintenance of follicular B cells
    Matthew D Thomas
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
    Immunity 23:275-86. 2005
    ..Thus, c-Myb is important during multiple stages of B-lymphopoiesis...
  31. ncbi Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding
    George W N White
    Biomolecular Structure and Design Program, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195 7610, USA
    J Mol Biol 350:757-75. 2005
    ..The presence and shape of the intermediate observed in the simulations were confirmed by small angle X-ray scattering experiments...
  32. pmc Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules
    J B Opalinska
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 32:5791-9. 2004
    ..We conclude that rationally targeted, OXE modified ODNs, can function efficiently as gene silencing agents, and hypothesize that they will prove useful for therapeutic purposes...
  33. pmc Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis
    Rumi Tominaga
    Plant Science Center, RIKEN, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Plant Cell 19:2264-77. 2007
    ..Furthermore, we showed by gel mobility shift assays that WER chimera proteins do not bind to the GL2 promoter region. However, a CPC chimera protein, which harbors the WER R3 motif, still binds to the GL2 promoter region...
  34. ncbi The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children
    Emmanuelle Clappier
    Genome Rearrangements and Cancer Group, Institut National de la Santé et de la Recherche Médicale U728 and Institut Universitaire d Hématologie, Paris 7 University, Hopital Saint Louis, Paris, France
    Blood 110:1251-61. 2007
    ..2 years) and with a proliferation/mitosis expression signature. By contrast, the MYB(dup) alteration was associated with the previously defined T-ALL subtypes...
  35. pmc Protein truncation is required for the activation of the c-myb proto-oncogene
    F A Grasser
    Institut fur Medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Universitatskliniken des Saarlandes, Homburg, Germany
    Mol Cell Biol 11:3987-96. 1991
    ..These results suggest that various alterations of c-Myb itself may determine the lineage of differentiating hematopoietic cells...
  36. pmc TRIPTYCHON and CAPRICE mediate lateral inhibition during trichome and root hair patterning in Arabidopsis
    S Schellmann
    ZMBP, Entwicklungsgenetik, Universitat Tubingen, Auf der Morgenstelle 3, D 72076 Tubingen, Germany
    EMBO J 21:5036-46. 2002
    ..Thus, the same lateral inhibition mechanism seems to be involved in both de novo patterning and position-dependent cell determination. We propose a model explaining trichome and root hair patterning by a common mechanism...
  37. ncbi Positive and negative determinants of target gene specificity in myb transcription factors
    Wanli Lei
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Biol Chem 279:29519-27. 2004
    ....
  38. pmc The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT
    Xiaolin Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:3663-73. 2002
    ..Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity...
  39. ncbi The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer
    Y H Hsiang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 154:5195-204. 1995
    ..Therefore, c-Myb or a related factor appears to play an important role in regulating the murine TCR-gamma enhancer...
  40. ncbi A dominant interfering Myb mutant causes apoptosis in T cells
    D Taylor
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Genes Dev 10:2732-44. 1996
    ..These data suggest a new and important role for Myb proteins as regulators of cell survival during hemopoiesis...
  41. ncbi Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner
    Øyvind Dahle
    Department of Biochemistry, University of Oslo, Norway
    Eur J Biochem 270:1338-48. 2003
    ..We propose that the negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on the sumoylation sites located here...
  42. pmc Regulation of T cell receptor delta gene rearrangement by c-Myb
    C Hernandez-Munain
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 183:289-93. 1996
    ..We demonstrate that an intact Myb binding site is necessary for efficient rearrangement of the minilocus substrate, suggesting that c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR-delta locus...
  43. ncbi Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins
    John J Rushton
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, USA
    Oncogene 22:308-13. 2003
    ....
  44. pmc c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
    Diane Maurice
    Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, London, UK
    EMBO J 26:3629-40. 2007
    ..We show that Gata3 is a direct target of c-Myb, and propose that c-Myb is an important regulator of Gata3, required for transduction of the T-cell receptor signal for subsequent helper cell lineage differentiation...
  45. ncbi The c-Myb oncoprotein
    T J Gonda
    Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Int J Biochem Cell Biol 30:547-51. 1998
    ..Together with data showing increased c-myb expression in colonic tumours, these observations raise the possibility that c-myb may play a role in human malignant disease...
  46. pmc Requirement of c-myb in T cell development and in mature T cell function
    Yen K Lieu
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Natl Acad Sci U S A 101:14853-8. 2004
    ..In addition, our data show that c-myb is directly involved in the formation of double-positive CD4+CD8+CD25+, CD4+CD25+, and CD8+CD25+ T cells, developmental processes that may imply a role for c-myb in autoimmune dysfunction...
  47. ncbi c-Myb a stem-progenitor cell regulator in multiple tissue compartments
    Robert G Ramsay
    Differentiation and Transcription Group, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Victoria, and the University of Melbourne, Department of Pathology, Parkville, Australia
    Growth Factors 23:253-61. 2005
  48. pmc A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene
    Georgina Lang
    The Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, UK
    Immunology 114:25-36. 2005
    ..Interaction of B-Myb with HSS8 may enhance bcl-2 gene expression by co-operating with positive regulatory elements (e.g. previously identified B-Myb response elements) or silencing negative response elements in the bcl-2 gene promoter...
  49. ncbi Cell-to-cell movement of the CAPRICE protein in Arabidopsis root epidermal cell differentiation
    Tetsuya Kurata
    Plant Science Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Kanagawa 230 0045, Japan
    Development 132:5387-98. 2005
    ..Furthermore, the fusion of CPC to tandem-GFPs defined the capability of CPC to increase the size exclusion limit of plasmodesmata...
  50. pmc The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties
    S Bergholtz
    Department of Biochemistry, University of Oslo, PO Box 1041 Blindern, N 0316 Oslo 3, Norway
    Nucleic Acids Res 29:3546-56. 2001
    ..Our data suggest that the small differences that have evolved between individual Myb family members lead to clear differences in DBD properties even if their sequence recognition remains the same...
  51. ncbi Ectopic expression of the Arabidopsis AtMYB23 gene induces differentiation of trichome cells
    V Kirik
    Institut fur Pflanzengenetik und Kulturpflanzenforschung, Corrensstrasse 3, 06466 Gatersleben, Germany
    Dev Biol 235:366-77. 2001
    ..Together, the presented data indicate that the AtMYB23 gene has partially overlapping functions with GLABRA1 in controlling the initiation of trichome development...
  52. pmc Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules
    Lida K Gifford
    Department of Chemistry, School of Arts and Sciences 231 South 34th Street, Philadelphia, PA 19104, USA
    Nucleic Acids Res 33:e28. 2005
    ..The general utility of this method is demonstrated by SQRM identification of targetable sequence within c-myb and bcl-6 mRNA. Corresponding antisense oligonucleotides reduce these gene products in cells...
  53. pmc Initiating inhibition. Control of epidermal cell patterning in plants
    M David Marks
    Department of Plant Biology, University of Minnesota, St Paul 55108 1095, USA
    EMBO Rep 4:24-5. 2003
  54. pmc A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
    Jennifer L Shepard
    Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13194-9. 2005
    ..Our findings show that zebrafish screens can uncover cancer pathways, and demonstrate that loss of function of bmyb is associated with cancer...
  55. pmc Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain
    Xianming Mo
    Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 19:2447-57. 2005
    ..Our data link a novel chromatin function of c-Myb with lineage-specific expression of differentiation genes and relate the loss of this function with the leukemic conversion of Myb...
  56. ncbi The WEREWOLF MYB protein directly regulates CAPRICE transcription during cell fate specification in the Arabidopsis root epidermis
    Kook Hui Ryu
    Department of Biology, Yonsei University, Sinchon 134, Seoul 120 749, Korea
    Development 132:4765-75. 2005
    ..These results provide experimental support for the proposed role of WER as an activator of gene transcription during the specification of both epidermal cell fates...
  57. pmc Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback
    Myeong Min Lee
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Plant Cell 14:611-8. 2002
    ..These results provide a molecular genetic framework for understanding the determination of a cell-type pattern in plants...
  58. ncbi Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb
    Hitomi Yamamoto
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Cell Growth Differ 13:69-75. 2002
    ..Our results suggest that CBP acts as a transcriptional coactivator of Spi-B and mediates synergistic or antagonistic interactions between other transcription factors...
  59. ncbi Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells
    Hiroyuki Kishi
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Blood 99:576-83. 2002
    ..These results suggest that cooperative binding of c-Myb and Pax-5 to the RAG-2 promoter is one of the mechanisms to direct the restricted expression of the RAG-2 in immature B cells...
  60. pmc Unifying features in protein-folding mechanisms
    Stefano Gianni
    Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 100:13286-91. 2003
    ..Thus, framework and nucleation-condensation are different manifestations of an underlying common mechanism...
  61. ncbi Chromatin organization and cell fate switch respond to positional information in Arabidopsis
    Silvia Costa
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Nature 439:493-6. 2006
    ..This ability to remodel chromatin organization may provide the basis for the plasticity in plant cell fate changes...
  62. ncbi The myb oncogene
    J S Lipsick
    Jonsson Comprehensive Cancer Center, University of California, School of Medicine, Los Angeles 90024
    Gene Amplif Anal 4:73-98. 1986
    ....
  63. ncbi Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation
    K C Ess
    Division of Molecular and Developmental Biology Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229, USA
    Oncogene 18:1103-11. 1999
    ..Based on these data, we hypothesize that c-Myb's function during cellular differentiation is both an activator of immature gene expression and a suppressor of terminal differentiation in diverse lineages...
  64. pmc Isolation of human cDNA clones of myb-related genes, A-myb and B-myb
    N Nomura
    Molecular Oncology Laboratory, Nippon Veterinary and Zootechnical College, Tokyo, Japan
    Nucleic Acids Res 16:11075-89. 1988
    ..Although it is a short stretch, domain III is found in the C-terminal region. The mRNAs of A-myb and B-myb were 5.0 and 2.6 kb, respectively. The mRNA expression pattern of the myb gene family in various tumors is presented...
  65. pmc MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Dev Cell 14:843-53. 2008
    ..These experiments show that miR-150 regulates MEP fate, and thus establish a role for miRNAs in lineage specification of mammalian multipotent cells...
  66. pmc Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus
    A Rascle
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon, UMR49 CNRS, France
    Mol Cell Biol 16:6338-51. 1996
    ....
  67. ncbi Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown
    Tone Berge
    Department of Molecular Biosciences, University of Oslo, N 0316 Oslo, Norway
    Blood Cells Mol Dis 39:278-86. 2007
    ....
  68. ncbi The human A-myb protein is a strong activator of transcription
    J Golay
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Oncogene 9:2469-79. 1994
    ..We have thus shown that the A-myb protein is a strong activator of transcription and that this activity depends on both the DNA-binding and acidic domains...
  69. ncbi Members of the nuclear factor kappa B family transactivate the murine c-myb gene
    C R Toth
    Department of Microbiology and Immunology, University of Virginia, Charlottesville 22903, USA
    J Biol Chem 270:7661-71. 1995
    ..Thus, the regulation of c-myb transcription may be quite complex, and members of the NF-kappa B family likely play an important role in this regulation...
  70. ncbi Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains
    T Takahashi
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    FEBS Lett 358:89-96. 1995
    ..These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb...
  71. ncbi MYB transcription factors in plants
    C Martin
    Department of Genetics, John Innes Centre, Colney, Norwich, UK
    Trends Genet 13:67-73. 1997
    ..However, while the functions of some plant MYB genes are relatively well understood they are, at present, quite distinct from their animal counterparts...
  72. ncbi Sequence selectivity of c-Myb in vivo. Resolution of a DNA target specificity paradox
    K B Andersson
    Department of Biochemistry, University of Oslo, N 0316 Oslo 3, Norway
    J Biol Chem 274:21986-94. 1999
    ....
  73. pmc Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression
    Charlene F Barroga
    Department of Medicine and Division of Hematology Oncology, University of California, San Diego School of Medicine, San Diego, CA 92103 8811, USA
    Exp Hematol 36:1585-92. 2008
    ..Micro RNAs (miRs) downregulate gene expression by binding to the 3' untranslated region (UTR) of specific messenger RNAs (mRNAs); we noted that the 3'UTR of c-Myb contains four miR-150 binding sites...
  74. pmc Two modes of c-myb activation in virus-induced mouse myeloid tumors
    G L Shen-Ong
    Mol Cell Biol 6:380-92. 1986
    ..These results suggest that truncated myb proteins play a role in neoplastic transformation of myeloid cells...
  75. pmc Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells
    Feng Fang
    Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Endocrinology 150:1597-606. 2009
    ..Taken together, these results indicate that c-Myb potentiates Stat5a-driven gene expression, possibly functioning as a Stat5a coactivator, in human breast cancer...
  76. ncbi Secondary structure of the DNA-binding domain of the c-Myb oncoprotein in solution. A multidimensional double and triple heteronuclear NMR study
    N Jamin
    DBCM, Service de Biochimie et Génétique Moléculaire, Gif sur Yvette, France
    Eur J Biochem 216:147-54. 1993
    ..The remaining C-terminal part of the R2 repeat, predicted to be helical and part of the HTH motif, undergoes intermediate conformational exchange processes. Stabilization of this segment might occur upon binding to DNA...
  77. ncbi Myb proteins in life, death and differentiation
    K Weston
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK
    Curr Opin Genet Dev 8:76-81. 1998
    ..Regulation of Myb proteins by phosphorylation and intermolecular cooperation has recently been demonstrated, together with a new role for the proteins, in the control of apoptosis...
  78. ncbi Alteration of cell adhesion and cell cycle properties of ES cells by an inducible dominant interfering Myb mutant
    N Iwai
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita 565-0871, Osaka, Japan
    Oncogene 20:1425-34. 2001
    ..These results are well consistent with the recent report on the phenotype of B-Myb null mice and show that the regulation of cell adhesion is an important B-Myb function that has not yet been assumed...
  79. ncbi Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis
    J Frampton
    European Molecular Biology Laboratory, Heidelberg, Germany
    Protein Eng 4:891-901. 1991
    ..Modelling also allowed positioning of adjacent repeats around the major groove over an 8 bp binding site...
  80. ncbi The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb
    Thomas Saether
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Biol Chem 282:13994-4005. 2007
    ..Interestingly, desumoylation of c-Myb potentiated the Myb-Mi-2alpha transactivational co-operation, as did co-transfection with p300...
  81. pmc c-Myb regulates the proliferation of immature thymocytes following beta-selection
    R Pearson
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    EMBO J 19:6112-20. 2000
    ..Super activation of c-Myb by Pim1 may therefore be required for beta-selection...
  82. pmc Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
    Paloma García
    College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK or
    EMBO J 28:1492-504. 2009
    ..Instead, cells positive for Kit and expressing low to medium levels of CD11b acquire self-renewing stem cell properties and are responsible for the perpetuation of the myeloproliferative phenotype...
  83. pmc Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines
    Anne P Rehmany
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Cell 17:1839-50. 2005
    ..The presence of the motif in additional secreted proteins from plant pathogenic oomycetes and its similarity to a host-targeting signal from malaria parasites suggest a conserved role in pathogenicity...
  84. ncbi GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter
    Petr Bartunek
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Oncogene 22:1927-35. 2003
    ..Thus, our study provides evidence for a direct molecular link between GATA-1 activity and c-myb proto-oncogene expression during terminal red cell differentiation...
  85. ncbi Isolation of a subfamily of genes for R2R3-MYB transcription factors showing up-regulated expression under nitrogen nutrient-limited conditions
    Kunihiko Miyake
    Plant Breeding Laboratory, Faculty of Agriculture, Hirosaki University, Hirosaki, Aomori 036 8561, Japan
    Plant Mol Biol 53:237-45. 2003
    ..On the other hand, an interesting relationship, in structure and function, was found between LjMYB101 and LjGln1, suggesting an alternative role for MYB101 in regulation of nitrogen metabolism...
  86. ncbi Cell-fate specification in the epidermis: a common patterning mechanism in the root and shoot
    John Schiefelbein
    Department of Molecular, Cellular, and Developmental Biology, 830 North University Avenue, University of Michigan, Ann Arbor 48109, USA
    Curr Opin Plant Biol 6:74-8. 2003
    ..The basic mechanism of lateral inhibition with feedback that has been uncovered by recent studies provides a conceptual framework for understanding how patterns of cell fate in general may be specified during plant development...
  87. pmc An Arabidopsis myb homolog is induced by dehydration stress and its gene product binds to the conserved MYB recognition sequence
    T Urao
    Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Plant Cell 5:1529-39. 1993
    ..Binding was sequence specific, as indicated by a gel mobility shift experiment. These results suggest that a MYB-related transcription factor is involved in the regulation of genes that are responsive to water stress in Arabidopsis...
  88. ncbi Differential combinatorial interactions of cis-acting elements recognized by R2R3-MYB, BZIP, and BHLH factors control light-responsive and tissue-specific activation of phenylpropanoid biosynthesis genes
    Ulrike Hartmann
    Department of Plant Breeding and Yield Physiology, Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, D 50829 Köln, Germany
    Plant Mol Biol 57:155-71. 2005
    ....
  89. ncbi Characterization of two Myb-like transcription factors binding to CAB promoters in wheat and barley
    Yuri Churin
    Institute of Biology, Humboldt University Berlin, Chausseestrasse 117, 10115 Berlin, Germany
    Plant Mol Biol 52:447-62. 2003
    ..These observations indicate that HvMCB1 and HvMCB2, together with other, yet unknown regulatory factors, may mediate responsiveness of CAB gene transcription to a variety of environmental and developmental signals...
  90. ncbi Functional interactions between a glutamine synthetase promoter and MYB proteins
    Josefa Gómez-Maldonado
    Biología Molecular y Bioquímica, Instituto Andaluz de Biotencología, Unidad Asociada UMA CSIC, Universidad de Malaga, Campus Universitairo de Teatinos, E 29071 Malaga, Spain
    Plant J 39:513-26. 2004
    ....
  91. ncbi MYB transcription factors are differentially expressed and regulated during secondary vascular tissue development in hybrid aspen
    Barbara Karpinska
    Department of Botany, Stockholm University, Lilla Frescativ 5, Stockholm, SE 10691, Sweden
    Plant Mol Biol 56:255-70. 2004
    ..Moreover a higher transcript level of caffeoyl-CoA 3-O-methyltransferase [CCoAOMT]; EC 2.1.1.104) was found in the phloem of the transgenic plants, suggesting that PttMYB21a might function as a transcriptional repressor...
  92. pmc Alternatively spliced products of the maize P gene encode proteins with homology to the DNA-binding domain of myb-like transcription factors
    E Grotewold
    Cold Spring Harbor Laboratory, NY 11724
    Proc Natl Acad Sci U S A 88:4587-91. 1991
    ..We show that P is required for accumulation in the pericarp of transcripts of two genes (A1 and C2) encoding enzymes for flavonoid biosynthesis--genes also regulated by C1 in the aleurone...
  93. ncbi Embryonic control of epidermal cell patterning in the root and hypocotyl of Arabidopsis
    Y Lin
    Department of Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 128:3697-705. 2001
    ..Thus, epidermal cell specification in the Arabidopsis seedling relies on the embryonic establishment of a patterning mechanism that is perpetuated postembryonically...
  94. pmc Floral asymmetry involves an interplay between TCP and MYB transcription factors in Antirrhinum
    Susie B Corley
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 102:5068-73. 2005
    ..In addition to its role in dorsal regions, RAD acts nonautonomously on lateral regions either directly, through RAD protein movement, or indirectly, through a signaling molecule...
  95. pmc The tomato transcription factor Pti4 regulates defense-related gene expression via GCC box and non-GCC box cis elements
    Suma Chakravarthy
    Boyce Thompson Institute for Plant Research, Ithaca, New York 14853 1801, USA
    Plant Cell 15:3033-50. 2003
    ..Thus, Pti4 appears to regulate gene expression directly by binding the GCC box and possibly a non-GCC box element and indirectly by either activating the expression of TF genes or interacting physically with other TFs...
  96. ncbi Transcriptional activation mediated by binding of a plant GATA-type zinc finger protein AGP1 to the AG-motif (AGATCCAA) of the wound-inducible Myb gene NtMyb2
    Kazuhiko Sugimoto
    Department of Molecular Genetics, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Plant J 36:550-64. 2003
    ..We also found that the AGP1 binding activity is highly enhanced by adenine methylation of the AG-motif by bacterial dam methylase...
  97. ncbi Identification of GhMYB109 encoding a R2R3 MYB transcription factor that expressed specifically in fiber initials and elongating fibers of cotton (Gossypium hirsutum L.)
    Jinfeng Suo
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    Biochim Biophys Acta 1630:25-34. 2003
    ..These results suggested that GhMYB109 likely plays a direct role in the initiation and elongation of cotton fiber cells...
  98. pmc A conserved MYB transcription factor involved in phosphate starvation signaling both in vascular plants and in unicellular algae
    V Rubio
    Centro Nacional de Biotecnologia, Campus de Cantoblanco, 28049 Madrid, Spain
    Genes Dev 15:2122-33. 2001
    ..PHR1-binding sequences are present in the promoter of Pi starvation-responsive structural genes, indicating that this protein acts downstream in the Pi starvation signaling pathway...
  99. pmc The BOTRYTIS SUSCEPTIBLE1 gene encodes an R2R3MYB transcription factor protein that is required for biotic and abiotic stress responses in Arabidopsis
    Tesfaye Mengiste
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907 2054, USA
    Plant Cell 15:2551-65. 2003
    ..BOS1 encodes an R2R3MYB transcription factor protein, and our results suggest that it mediates responses to signals, possibly mediated by reactive oxygen intermediates from both biotic and abiotic stress agents...
  100. ncbi Salt tolerance-related protein STO binds to a Myb transcription factor homologue and confers salt tolerance in Arabidopsis
    Shuuichi Nagaoka
    Asian Natural Environmental Science Center, The University of Tokyo, University Farm, 1 1 1 Midori cho, Nishitokyo shi, Tokyo 188 0002, Japan
    J Exp Bot 54:2231-7. 2003
    ..These results suggest that STO is involved in salt-stress responses in Arabidopsis...
  101. pmc Transcription regulation by murine B-myb is distinct from that by c-myb
    R J Watson
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Nucleic Acids Res 21:267-72. 1993
    ..Results obtained here demonstrate that the activities of B-Myb and c-Myb are clearly distinct and suggest that these related proteins may have different functions in regulation of target gene expression...

Research Grants17

  1. Mutations and target genes in Adenoid Cystic Carcinoma
    Scott A Ness; Fiscal Year: 2013
    ..We will investigate the functions of the aberrant regulatory protein produced in these tumors to determine how it contributes to tumor formation and to plot new strategies for disrupting its functions as treatments for this disease. ..
  2. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
    ..We propose to develop a cell culture assay for transformation by this activated form of c-Myb and to investigate its biochemical and biological properties. ..
  3. Gene Regulation by Myb Proteins
    Joseph Lipsick; Fiscal Year: 2005
    ....
  4. STRUCTURE AND FUNCTION OF MYB ONCOGENE IN NEURONAL CELLS
    Richard Press; Fiscal Year: 1993
    ..The productive nature of the entire lab environment will serve as an excellent role model upon which to base my plans for an academic career as an independent biomedical scientist...
  5. ROLE OF C-MYB IN T-LYMPHOCYTES PROLIFERATION
    Bruno Calabretta; Fiscal Year: 1991
    ..These studies should enable us to determine at which level and by which mechanism(s) the human c-myb gene controls cell proliferation in T lymphocytes...
  6. Examing Oligonucleotide Effects on Gene Expression
    Alan Gewirtz; Fiscal Year: 2007
    ..It is our belief that such molecules will have an important impact on the diagnosis, and treatment of neoplastic diseases. ..
  7. Developing Nucleic Acid Therapeutics
    Alan Gewirtz; Fiscal Year: 2007
    ..abstract_text> ..
  8. HIV as a key regulator of c-MYB in human cells
    Robert Ramsay; Fiscal Year: 2004
    ..We hypothesize that Tat activates c-MYB in macrophages and that a thorough understanding of this process will advance our goal of blocking HIV transcription. ..
  9. iCyt Reflection Cell Sorter
    TIMOTHY BENDER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. A QTL for fetal hemoglobin and F cells on chromosome 8q
    Swee Thein; Fiscal Year: 2003
    ..The discovery of these factors may also suggest new approaches for therapeutic augmentation of fetal hemoglobin production in patients with SCD and beta thalassemia. ..
  11. BRCA1 Modulates Estrogen Receptor Response in Breast Cancer
    Eliot Rosen; Fiscal Year: 2009
    ..In addition to their implications for breast cancer pathogenesis, these studies are of practical importance, since they may suggest novel approaches for breast cancer prevention and treatment. ..
  12. BRCA Genes in Breast Cancer Chemoprevention
    Eliot Rosen; Fiscal Year: 2009
    ..The latter may be particularly useful, since recent studies suggest that Tamoxifen may not protect women with BRCA1 mutations from developing breast cancer. ..
  13. Protection Against Apoptosis by Scatter Factor
    Eliot Rosen; Fiscal Year: 2006
    ..Since SF may ameliorate certain forms of organ injury, understanding how it inhibits apoptosis may also provide new targets for the treatment of developmental, inflammatory, or toxic disorders. ..
  14. c-myb in B Cell Development and Function
    TIMOTHY BENDER; Fiscal Year: 2009
    ..abstract_text> ..
  15. Myb protein specificity in human hematopoietic cells
    Scott Ness; Fiscal Year: 2009
    ..The proposed experiments build on our expertise and extensive preliminary and published data and have great relevance to the study of alternative RNA splicing, the activity of Myb proteins and human leukemia. ..
  16. Regulation of the v-Myb and c-Myb Oncoproteins
    Scott A Ness; Fiscal Year: 2010
    ....
  17. Role of BRCA1 as a Human Tumor Suppressor Gene
    Eliot Rosen; Fiscal Year: 2008
    ..It is hoped that knowledge gained from these studies will lead to new approaches to cancer control and treatment. ..