t box domain proteins

Summary

Summary: Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.

Top Publications

  1. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
  2. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  3. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
  4. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
  5. ncbi T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    Michael J Townsend
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Immunity 20:477-94. 2004
  6. ncbi T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
  7. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
  8. ncbi Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
    M Bamshad
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Nat Genet 16:311-5. 1997
  9. ncbi Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nature 432:107-12. 2004
  10. ncbi Isl1Cre reveals a common Bmp pathway in heart and limb development
    Lei Yang
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 133:1575-85. 2006

Research Grants

  1. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
  2. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
  3. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
  5. The Role of Eomesodermin in Cardiac Development
    Kenneth Ryan; Fiscal Year: 2007
  6. Molecular Genetics of Carney Complex
    Cathy J Hatcher; Fiscal Year: 2010
  7. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2008
  8. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
  9. Arming the Immune System Against Pathogens
    Laurie Glimcher; Fiscal Year: 2007
  10. Requirements for the FGF/MAPK in early heart development
    Frank Conlon; Fiscal Year: 2007

Detail Information

Publications261 found, 100 shown here

  1. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
  2. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  3. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency...
  4. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
    ..Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2...
  5. ncbi T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    Michael J Townsend
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Immunity 20:477-94. 2004
    ..Our results identify T-bet as a key factor in the terminal maturation and peripheral homeostasis of NK and Valpha14i NKT cells...
  6. ncbi T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell...
  7. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ....
  8. ncbi Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
    M Bamshad
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Nat Genet 16:311-5. 1997
    ..We suggest that during the evolution of TBX3 and TBX5 from a common ancestral gene, each has acquired specific yet complementary roles in patterning the mammalian upper limb...
  9. ncbi Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nature 432:107-12. 2004
    ....
  10. ncbi Isl1Cre reveals a common Bmp pathway in heart and limb development
    Lei Yang
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 133:1575-85. 2006
    ..Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo...
  11. ncbi Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
    Y Hiroi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nat Genet 28:276-80. 2001
    ..These results indicate that two different types of cardiac transcription factors synergistically induce cardiac development...
  12. ncbi Eomesodermin is required for mouse trophoblast development and mesoderm formation
    A P Russ
    Wellcome CRC Institute for Cancer and Developmental Biology, and Department of Physiology, University of Cambridge, UK
    Nature 404:95-9. 2000
    ..Our results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast...
  13. ncbi T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
  14. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  15. ncbi Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
    Kazuko Koshiba-Takeuchi
    Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nat Genet 38:175-83. 2006
    ..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes...
  16. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  17. pmc A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
    Masao Murakami
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390 9148, USA
    Proc Natl Acad Sci U S A 102:18034-9. 2005
    ..These findings reveal key roles for TAZ and YAP in the control of TBX5-dependent transcription and suggest the involvement of these coactivators in cardiac and limb development...
  18. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  19. ncbi Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development
    D L Chapman
    Department of Genetics and Development, College of Physicans and Surgeons, Columbia University, New York, New York 10032, USA
    Dev Dyn 206:379-90. 1996
    ..These studies are a good indication that the T-box family of genes has important roles in inductive interactions in many stages of mammalian embryogenesis...
  20. ncbi Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning
    A C Lekven
    Department of Pharmacology and Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195, USA
    Dev Cell 1:103-14. 2001
    ..These data demonstrate that the zebrafish wnt8 locus is required during gastrulation to pattern both the mesoderm and the neural ectoderm properly...
  21. pmc Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Cell 15:121-33. 2008
    ..We propose that a positive autoregulatory loop between Ntl/Bra and canonical Wnt signaling maintains the mesodermal progenitors to facilitate posterior somite development in chordates...
  22. ncbi Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
    Keith W Vance
    Signaling and Development Laboratory, Marie Curie Research Institute, Surrey, United Kingdom
    Cancer Res 65:2260-8. 2005
    ..The results suggest that the activity of endogenous Tbx2 is critically required to maintain proliferation and suppress senescence in melanomas...
  23. ncbi Asthmatic changes in mice lacking T-bet are mediated by IL-13
    Susetta Finotto
    Laboratory of Cellular and Molecular Immunology of the Lung, University of Mainz, Mainz, Germany
    Int Immunol 17:993-1007. 2005
    ..These data highlight a T-bet-directed function for IL-13 in controlling lung remodeling that is both dependent on and independent of its interaction with TGF-beta in the asthmatic airway...
  24. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ....
  25. ncbi Cloning and expression analysis of the mouse T-box gene tbx20
    F Kraus
    Max Planck Institut fur Immunbiologie, Abt Molekulare Embryologie, Stubeweg 51, 79108 Freiburg, Germany
    Mech Dev 100:87-91. 2001
    ..Expression is prominent in the extraembryonic mesoderm, in the developing heart, the eye anlage and motor neurons of hindbrain and spinal cord...
  26. ncbi The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans
    Tatjana Piotrowski
    National Institutes of Health, NICHD, LMG, Bldg 6B, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Development 130:5043-52. 2003
    ..Furthermore, we provide evidence for regulatory interactions between vgo/tbx1 and edn1 and hand2, genes that are implicated in the control of pharyngeal arch development and in the etiology of DGS...
  27. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  28. ncbi Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract
    Huansheng Xu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Development 131:3217-27. 2004
    ..Furthermore, our data link, for the first time, the function of the secondary heart field to congenital heart disease...
  29. pmc Identification of downstream genetic pathways of Tbx1 in the second heart field
    Jun Liao
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Dev Biol 316:524-37. 2008
    ..When taken together, our studies show that Tbx1 acts upstream in a genetic network that positively regulates SHF cell proliferation and negatively regulates differentiation, cell-autonomously in the caudal pharyngeal region...
  30. ncbi Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    A C Mullen
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Science 292:1907-10. 2001
    ..These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage...
  31. pmc The Brachyury gene encodes a novel DNA binding protein
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
    EMBO J 12:3211-20. 1993
    ..The latter proteins also recognize the consensus DNA binding site. We suggest that the T protein is involved in the control of genes required for mesoderm formation, and for the differentiation and function of chorda mesoderm...
  32. pmc T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
    Graham M Lord
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Blood 106:3432-9. 2005
    ..T-bet is also required for the expression of the chemokine receptor CXCR3. Thus, T-bet controls Th1-cell migration to inflammatory sites, which has fundamental consequences for the control of immunologic disease...
  33. ncbi Cloning and expression analysis of the mouse T-box gene Tbx18
    F Kraus
    Max Planck Institut fur Immunbiologie, Abt Molekulare Embryologie, Stubeweg 51, 79108 Freiburg, Germany
    Mech Dev 100:83-6. 2001
    ..Other sites of expression include the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge, and the developing limb buds...
  34. ncbi Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
    C W Muller
    European Molecular Biology Laboratory, Grenoble Outstation, France
    Nature 389:884-8. 1997
    ..Thus the structure of this T domain complex with DNA reveals a new way in which a protein can recognize DNA...
  35. ncbi Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
    Alan C Mullen
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Nat Immunol 3:652-8. 2002
    ..These findings suggest that heritable states of gene expression might be maintained by continued expression of the inducing factor or by a mechanism that confers a stable imprint of the induced state...
  36. ncbi Mouse models of 22q11 deletion syndrome
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Psychiatry 59:1172-9. 2006
    ..Significant progress has already been made, and recent studies in the mouse suggest that several genes from the deleted region affect behavior and might contribute to disease burden in patients...
  37. ncbi Axis-inducing activities and cell fates of the zebrafish organizer
    L Saude
    Division of Developmental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 127:3407-17. 2000
    ..We conclude that the deep tissue included in our transplants is important for proper head formation...
  38. ncbi Identification and localization of TBX5 transcription factor during human cardiac morphogenesis
    C J Hatcher
    Cardiology Division, Department of Medicine and Department of Cell Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Dev Dyn 219:90-5. 2000
    ..Human cardiac expression of TBX5 protein correlates with the cardiac manifestations of Holt-Oram syndrome. TBX5 transmyocardial protein gradients may contribute to normal patterning of the human heart during embryogenesis...
  39. ncbi Different regulation of T-box genes Tbx4 and Tbx5 during limb development and limb regeneration
    Paul Khan
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Institute for Education and Research, Chicago, Illinois 60614, USA
    Dev Biol 250:383-92. 2002
    ..This indicates that, on a molecular level, different regulatory mechanisms control the shaping of identical limb structures and that regeneration is not simply a reiteration of developmental gene programs...
  40. ncbi Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse
    Christopher B Brown
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 267:190-202. 2004
    ....
  41. ncbi Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor
    Sharon Prince
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Cancer Res 64:1669-74. 2004
    ....
  42. pmc IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
    Eun Sook Hwang
    Division of Molecular Life Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea
    J Exp Med 202:1289-300. 2005
    ..Heterodimerization of T-bet and RelA interferes with the binding of RelA to the IL-2 promoter, and hence, transcriptional activation of the IL-2 gene by RelA...
  43. ncbi Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
    Mercedes Rodriguez
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7872-81. 2008
    ....
  44. ncbi Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation
    D Clements
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Mech Dev 56:139-49. 1996
    ..Additionally, the data suggest the possibility that axial and non-axial mesoderm are distinct from the earliest stages of Brachyury expression...
  45. pmc Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Anat 205:1-13. 2004
    ..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1...
  46. ncbi The T-box gene family
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Bioessays 20:9-19. 1998
    ..This review presents a current overview of progress made in the analysis of T-box genes and their products in a variety of model systems...
  47. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments...
  48. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  49. ncbi Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome
    B G Bruneau
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Dev Biol 211:100-8. 1999
    ....
  50. pmc Identification of direct T-box target genes in the developing zebrafish mesoderm
    Aaron T Garnett
    Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Development 136:749-60. 2009
    ..We also find that deltaD is directly activated by T-box factors in the tail bud, where it has been implicated in starting the segmentation clock, suggesting that spt and ntl act upstream of this process...
  51. ncbi T-box genes: what they do and how they do it
    J Smith
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK NW7 1AA
    Trends Genet 15:154-8. 1999
    ..An understanding of how the T-box genes act requires analysis of how their expression is controlled, identification of their target genes, and an insight into how different family members exert different effects...
  52. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE...
  53. ncbi Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
    Pooja Agarwal
    Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 130:623-33. 2003
    ..These data suggest common pathways for the differentiation and growth of embryonic structures downstream of T-box genes...
  54. ncbi The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation
    A Jazwinska
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Cell 96:563-73. 1999
    ..brk itself is negatively regulated by Dpp. Dpp signaling might relieve brk's repression of low-level target genes either by transcriptional repression of brk or by antagonizing a repressor function of brk at the target gene promoters...
  55. ncbi The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    Willem M H Hoogaars
    Experimental and Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 62:489-99. 2004
    ..We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS)...
  56. pmc T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
    A A Lighvani
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:15137-42. 2001
    ..These findings substantially alter the current view of T-bet in IFN-gamma regulation and promotion of cell-mediated immune responses...
  57. ncbi Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:977-87. 2006
    ..These results show that Tbx1 in the PE is required for the patterning and development of the pharyngeal apparatus, thereby disrupting the formation of its derivative structures...
  58. ncbi GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:415-28. 2003
    ..These findings reassert that Stat4 signaling is a central element of Th1/Th2 development...
  59. ncbi Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene
    C Chieffo
    The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 43:267-77. 1997
    ..Later in development, expression is seen in the vertebral column and tooth bud. Thus, human TBX1 is a candidate for some of the features seen in the 22q11 deletion syndrome...
  60. pmc The T-box family
    Val Wilson
    Department of Genetics, 220 Fordham Hall, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Genome Biol 3:REVIEWS3008. 2002
    ....
  61. pmc Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    Brendan A Hilliard
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 110:843-50. 2002
    ..Thus, unlike NF-kappaB1, which selectively regulates Th2 cell differentiation, c-Rel is essential for Th1 cell differentiation and Th1 cell-mediated autoimmune inflammation...
  62. ncbi The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator
    Merel E Lingbeek
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:26120-7. 2002
    ..Importantly, this suggests a hitherto unsuspected level of specificity associated with T-box factors and corresponding recognition sites in regulating their target genes in vivo...
  63. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  64. pmc Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    Am J Hum Genet 81:280-91. 2007
    ..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up...
  65. pmc Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
    S Carreira
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 18:5099-108. 1998
    ....
  66. pmc Adult generation of glutamatergic olfactory bulb interneurons
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 12:1524-33. 2009
    ..Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair...
  67. ncbi Role of TBX1 in human del22q11.2 syndrome
    Hisato Yagi
    Division of Genomic Medicine, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Lancet 362:1366-73. 2003
    ..At least 30 genes have been mapped to the deleted region. However, the association of these genes with the cause of this syndrome is not clearly understood...
  68. ncbi Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis
    Jun K Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
    Development 130:5953-64. 2003
    ..Taken together, our data indicate that Tbx5 specifies the identity of LV through tight interactions among several heart-specific factors, and highlight the essential roles of Tbx5 in cardiac development...
  69. pmc T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
    Anubhav N Mathur
    Department Microbiology and Immunology, Indiana University School of Medicine, 702 Barnhill Dr, RI 2600, Indianapolis, IN 46202, USA
    Blood 108:1595-601. 2006
    ..The transient nature of the Th1beta phenotype suggests that these cells are a component of type I immunity and that T-bet expression is a critical determinant of Th1 versus Th1beta cell fate...
  70. ncbi T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..These findings provide the first evidence that Tbx2 is a determinant in the local repression of chamber-specific gene expression and chamber differentiation...
  71. ncbi TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:6567-72. 2002
    ..These data suggest that the hypoproliferative features of this genetic disorder may be caused, at least in part, by deregulated expression of p14(ARF)...
  72. pmc The T protein encoded by Brachyury is a tissue-specific transcription factor
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    EMBO J 14:4763-72. 1995
    ..T can also transactivate transcription through variously oriented and spaced T sites, a fact that may be relevant in the search for genes controlled by T protein and important in mesoderm development...
  73. ncbi Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
    Q Y Li
    Department of Genetics, University of Nottingham, Queen s Medical Centre, UK
    Nat Genet 15:21-9. 1997
    ..Tissue in situ hybridization studies on human embryos from days 26 to 52 of gestation reveal expression of TBX5 in heart and limb, consistent with a role in human embryonic development...
  74. ncbi Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
    ..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
  75. ncbi Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
    Amy E Lovett-Racke
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 USA
    Immunity 21:719-31. 2004
    ..Since T-bet regulates IFNgamma production in CD4(+) T cells, but to a lesser extent in most other IFNgamma-producing cells, T-bet may be a target for therapeutics for Th1-mediated diseases...
  76. ncbi Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome
    C T Basson
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 15:30-5. 1997
    ..We conclude that TBX5 is critical for limb and heart development and suggest that haploinsufficiency of TBX5 causes Holt-Oram syndrome...
  77. ncbi Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
    Philippe Stock
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nat Immunol 5:1149-56. 2004
    ..Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs...
  78. ncbi Mode of action of VegT in mesoderm and endoderm formation
    D Clements
    Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Development 126:4903-11. 1999
    ....
  79. ncbi The T genes in embryogenesis
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Trends Genet 10:280-6. 1994
    ..Homologous genes have been cloned from the frog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian Halocynthia roretzi. The T gene is an important tool for elucidating mesoderman and embryonic pattern formation...
  80. ncbi Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects
    Vasco Meneghini
    Dulbecco Telethon Institute CNR ITB, Via Fratelli Cervi 93, 20090 Segrate, Milano, Italy
    Eur J Med Genet 49:151-8. 2006
    ..A possible explanation is that mutant TBX3 proteins that retain the T-domain, if translated, might be minimally active in promoting/repressing transcription of target genes in the limbs and in other embryonic tissues...
  81. ncbi T-box genes and heart development: putting the "T" in heart
    Timothy F Plageman
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, ML7020, Cincinnati, Ohio 45229, USA
    Dev Dyn 232:11-20. 2005
    ..The molecular hierarchies and developmental processes controlled by T-box genes in the heart are the focus of this review...
  82. pmc Teasing out T-box targets in early mesoderm
    Fiona C Wardle
    Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK
    Curr Opin Genet Dev 18:418-25. 2008
    ....
  83. ncbi Cell cycle regulation of the T-box transcription factor tbx2
    Bilada Bilican
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK
    Exp Cell Res 312:2358-66. 2006
    ..The results are consistent with Tbx2 playing a role in cell cycle progression and organization of subnuclear compartments...
  84. ncbi Dissecting contiguous gene defects: TBX1
    Antonio Baldini
    Center for Cardiovascular Development, Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Genet Dev 15:279-84. 2005
    ..Tbx1 is an excellent tool to probe the genetic network governing embryonic pharyngeal development...
  85. pmc Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    Estelle Bettelli
    Center for Neurologic Diseases, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Exp Med 200:79-87. 2004
    ..Although the two transcription factors, STAT1 and T-bet, both induce IFN-gamma gene transcription, our results demonstrate marked differences in their function in regulating pathogenic Th1 cell responses...
  86. pmc Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
    Eon Joo Park
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 133:2419-33. 2006
    ..These findings provide a novel insight into how the formation and remodeling of primary and anterior heart field-derived structures rely on Fgf8 signals from discrete temporospatial domains...
  87. ncbi The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate
    Sharon L Amacher
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 129:3311-23. 2002
    ....
  88. pmc Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex
    Tom Kowalczyk
    Departments of Neurological Surgery and Pathology, University of Washington and Center for Neuroscience, Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Cereb Cortex 19:2439-50. 2009
    ..Our findings support the hypothesis that regulated amplification of INPs may be an important factor controlling the balance of neurogenesis among different cortical layers...
  89. ncbi Expression of the genes Emx1, Tbr1, and Eomes (Tbr2) in the telencephalon of Xenopus laevis confirms the existence of a ventral pallial division in all tetrapods
    Aurora Brox
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 474:562-77. 2004
    ..Finally, expression of xTbr1, xEomes, and xEmx1 is observed in the mitral cell layer of the olfactory bulb from early developmental stages, further supporting that this structure is a pallial derivative...
  90. pmc The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 22:2479-84. 2008
    ..Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ...
  91. pmc Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease
    Li Qian
    Development and Aging Program, Del E Webb Neuroscience, Aging and Stem Cell Research Center NASCR, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:19833-8. 2008
    ..These findings suggest that the fly heart might serve as an identifier of candidate genes involved in human heart disease...
  92. ncbi TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors
    Colleen S Sinclair
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 62:3587-91. 2002
    ..TBX2 was determined to be preferentially amplified and overexpressed in BRCA1 and BRCA2 mutant tumors, whereas RPS6KB1 was not, suggesting a role for TBX2 amplification in the development of BRCA1- and BRCA2-associated breast tumors...
  93. ncbi Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
    Fiona A Stennard
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, 2010, Sydney, Australia
    Dev Biol 262:206-24. 2003
    ..We propose that Tbx20 plays an integrated role in the ancient myogenic program of the heart, and has been additionally coopted during evolution of vertebrates for endocardial cushion development...
  94. pmc Evolution of mouse T-box genes by tandem duplication and cluster dispersion
    S I Agulnik
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Genetics 144:249-54. 1996
    ..This analysis suggests that Tbx4 and Tbx5 are cognate genes that diverged apart from a common ancestral gene during early vertebrate evolution...
  95. pmc Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
    Jingsong Wang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 116:414-21. 2006
    ..T-bet provides an attractive new target for the development of novel therapeutics for inflammatory arthritis...
  96. pmc A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence
    CAROLINE E BURNS
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:5776-82. 2009
    ..Together, our results establish a hierarchy of signaling programs required and sufficient for HSC emergence in the AGM...
  97. ncbi TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines
    Weiwei Fan
    Division of Genetics, Department of Pediatrics, Robert R Sprague Hall 314, University of California Irvine, Irvine, CA 92697, USA
    Cancer Res 64:5132-9. 2004
    ..A subset of human breast cancer cell lines overexpresses TBX3. Our results indicate that TBX3 and TBX3 + 2a are functionally distinctive in inhibition of senescence of MEF cells and may play a role in breast cancer...
  98. ncbi Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity
    M Logan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, MA 02115, USA
    Development 125:2825-35. 1998
    ....
  99. ncbi T-box genes in human disorders
    Elizabeth A Packham
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Hum Mol Genet 12:R37-44. 2003
    ..This review describes the key features of these disorders and the involvement of T-box genes in their phenotype...
  100. ncbi Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    ....
  101. ncbi The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome
    Daniel Bachiller
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 130:3567-78. 2003
    ..The chordin mutation provides a mouse model for head and neck congenital malformations that frequently occur in humans and suggests that chordin/Bmp signaling may participate in their pathogenesis...

Research Grants58

  1. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  2. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
    ..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..
  3. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
  5. The Role of Eomesodermin in Cardiac Development
    Kenneth Ryan; Fiscal Year: 2007
    ..AIM 4. In situ hybridization is used to determine the full range of cardiac cell types expressing Eomes; a conditional dominant-negative isoform of Eomes examines the requirement for Eomes in the heart. ..
  6. Molecular Genetics of Carney Complex
    Cathy J Hatcher; Fiscal Year: 2010
    ....
  7. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2008
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  8. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
    ..Identification of these variants may have a significant impact on the public health of asthma patients. ..
  9. Arming the Immune System Against Pathogens
    Laurie Glimcher; Fiscal Year: 2007
    ..The overall objective of this interdependent, interdisciplinary team is to develop molecules that modulate the host immune system so as to augment the protective effects of vaccines against microbial pathogens. ..
  10. Requirements for the FGF/MAPK in early heart development
    Frank Conlon; Fiscal Year: 2007
    ..abstract_text> ..
  11. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  12. A Genetic Approach to Organogenesis in Xenopus
    Frank Conlon; Fiscal Year: 2006
    ..tropicalis. Two, determine the role of Shp-2 and Tbx5 in organ development through the generation of an allelic series of Shp-2 and Tbx5 in X. tropicalis. [unreadable] [unreadable]..
  13. Analysis of Thymic Epithelial Precursor Cells
    Georg Hollander; Fiscal Year: 2008
    ..abstract_text> ..
  14. NIP45: A Novel Nuclear Protein that Regulates IL-4
    Laurie Glimcher; Fiscal Year: 2008
    ..abstract_text> ..
  15. Molecular basis of vascular heterogenity and function
    Jonathan Epstein; Fiscal Year: 2008
    ..abstract_text> ..
  16. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  17. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..Our studies will provide crucial information about GTPBPs which may eventually translate into clinical treatments for diseases caused by abnormal TGF[unreadable] or GTPBP signaling. ..
  18. TRAF4 in TGF-beta Signaling and Embryonic Development
    GERALD THOMSEN; Fiscal Year: 2009
    ....
  19. TRANSCRIPTIONAL CONTROL OF HUMAN T CELL RECEPTOR GENES
    Laurie Glimcher; Fiscal Year: 2009
    ..abstract_text> ..
  20. PAX3 REGULATION OF CARDIAC CONOTRUNCAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2008
    ..Aim 3 examines the role of neural crest during development of the conduction system, and specifically examines Pax3 regulation of DCT. [unreadable] [unreadable]..
  21. TRANSCRIPTIONAL REGULATION OF THE IMMUNE RESPONSE
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2010
    ..4) Examine the role of XBP-1 in autoimmune disease.5) Investigate the requirement of XBP-1 for the development and propagation of plasma cell neoplasms. ..
  22. Disease pathogenesis of Noonan syndrome and related disorders
    Bruce Gelb; Fiscal Year: 2008
    ..Next, a candidate gene approach will be used to identify additional NS gene(s). This will be coupled with the use of human multiplex NS kindreds without PTPN11 mutations. ..
  23. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2008
    ..abstract_text> ..
  24. The acd mouse: a model for congenital adrenal hypoplasia
    Catherine Keegan; Fiscal Year: 2006
    ..Ultimately, through this additional training I will be poised to continue my long-term career goal of becoming an Independent Investigator. ..
  25. Mechanisms ot Maternal Immune Tolerence
    Laurie Glimcher; Fiscal Year: 2006
    ..abstract_text> ..
  26. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2004
    ..Aside from illuminating one pathway toward the clinical endpoint of PDA, it will provide the starting place for identifying genes critical to ductal development that are activated by Char syndrome-related genes. ..
  27. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  28. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    ..abstract_text> ..
  29. THE ROLE OF UFD1 AND CDC45 IN NEURAL CREST DEVELOPMENT
    Vidu Garg; Fiscal Year: 2004
    ..The function of Cdc45 will be examined in vivo in chick embryos by retrovirally mediated alteration of gene expression. A yeast two hybrid assay will be utilized to determine if Ufdl, Cdc45, and Hira interact with one another. ..
  30. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  31. The role of the FOXA protein PHA-4 in gonad development
    JULIE KIEFER; Fiscal Year: 2004
    ..These experiments will not only extend our understanding of how gonad development is specified, but they will also help to determine at a molecular level how FOXA proteins regulate developmental decisions. ..
  32. TRANSCRIPTION FACTOR NFATP IN CHONDROGENESIS
    Laurie Glimcher; Fiscal Year: 2004
    ....
  33. GENE REGULATION IN T HELPER 1 CELLS
    Laurie Glimcher; Fiscal Year: 2004
    ..abstract_text> ..
  34. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    ..Finally, gene targeting in the mouse will be used to study the biological activities of Mga and the individual roles of its bHLHZip domain and T-domain. ..
  35. T LYMPHOCYTE ACTIVATION, DIFFERENTIATION AND DEATH
    Laurie Glimcher; Fiscal Year: 2002
    ..The Keystone Symposia has the advantage of allowing a large number of junior scientists and scientists in training to attend while being focused under a single theme, in this case T lymphocyte activation, signaling and death. ..
  36. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  37. Roles of TBX3 and its Isoform, TBX3+2a, in Breast Cancer
    Taosheng Huang; Fiscal Year: 2005
    ..By working with both an animal model and tissue acquired from breast surgeries, the proposed research aims to optimize the clinical relevance of the work. ..
  38. Smurf Ubiquitin Ligases in Xenopus Development
    GERALD THOMSEN; Fiscal Year: 2005
    ..We have already isolated 89 Smurf1-interacting clones, including Smad1, a known Smurf1 target. ..
  39. TRANSCRIPTIONAL CONTROL OF INTERFERON-GAMMA IN T AND NK CELLS
    AMY SUSAN WEINMANN; Fiscal Year: 2010
    ....
  40. 2005 NNFF Consortium for NF1, NF2 and Schwannomatosis
    Jonathan Epstein; Fiscal Year: 2005
    ....
  41. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    AVERIL I MA; Fiscal Year: 2010
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
  42. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  43. LBX2 AND UROGENITAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2002
    ....
  44. GENES INVOLVED IN AIDS LYMPHOMAGENESIS
    Michael Teitell; Fiscal Year: 2002
    ..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
  45. ALLERGIC AIRWAY RESPONSES--IMMUNE DEVIATION AND MEMORY
    Mark Boothby; Fiscal Year: 2002
    ....
  46. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
    ..Success in this research could lead to new therapeutic strategies in allergic diseases or asthma. ..
  47. Memory CD4 T cell-mediated immunopathology in influenza infection
    DONNA FARBER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. The Role of Toll-Like Receptors in T Cell memory
    DONNA FARBER; Fiscal Year: 2006
    ..Second, that engagement of TLR2 on the T cells themselves will differentially promote the generation of long-lived antigen-specific CD4+ Tmem cells in lymphoid and non-lymphoid tissues. ..
  49. BIOCHEMICAL ANALYSIS OF IMMUNOLOGICAL MEMORY
    DONNA FARBER; Fiscal Year: 2007
    ..abstract_text> ..
  50. Integration of Stat6, Co-regulation, and Gene Expression
    Mark Boothby; Fiscal Year: 2007
    ..Taken together, the experiments of these Specific Aims will provide new insights into the regulation of lymphocyte function in immune responses. ..
  51. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2004
    ..Taken together, the experiments of these Specific Aims will provide new insights into the regulation of the effector and memory-phenotype Th2 subsets. ..
  52. Specification of embryonic C. elegans mesoderm by a T-box factor
    Morris Maduro; Fiscal Year: 2008
    ..elegans may shed light on how development goes awry, a process which can lead to birth defects or cancer. [unreadable] [unreadable] [unreadable]..
  53. Transcriptional Regulation of the Type 1 T Cell Response
    Mark Boothby; Fiscal Year: 2005
    ..Together, the proposed experiments will provide important insights into the transcriptional regulation of T cell-dependent inflammatory responses. ..
  54. Heterogeneous Subsets of Memory CD4 T cells
    DONNA FARBER; Fiscal Year: 2007
    ..This research proposal will therefore address the basic mechanisms underlying memory T cell heterogeneity, using novel cellular immunologic and molecular approaches. ..
  55. Investigating the Role of Tbx1 in Ear Development
    Evan Braunstein; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2006
    ....
  57. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2006
    ..abstract_text> ..