fetal proteins

Summary

Top Publications

  1. ncbi An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma
    Andrew C Nelson
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London, SE1 1UL, UK
    J Pathol 228:274-85. 2012
  2. ncbi Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
    J C Corbo
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Development 124:589-602. 1997
  3. ncbi BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
    Debalina Sarkar
    North West Cancer Research Fund Institute, School of Biological Sciences, Bangor University, Bangor, Gwynedd, United Kingdom
    Int J Cancer 130:328-37. 2012
  4. pmc T (brachyury) gene duplication confers major susceptibility to familial chordoma
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Nat Genet 41:1176-8. 2009
  5. pmc The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
    Romaine I Fernando
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:533-44. 2010
  6. pmc Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
    Mario Roselli
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
    Clin Cancer Res 18:3868-79. 2012
  7. ncbi Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis
    Stephane Romero
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Cell 119:419-29. 2004
  8. ncbi Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases
    Nirmala A Jambhekar
    Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
    Arch Pathol Lab Med 134:1181-7. 2010
  9. ncbi Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study
    Nadege Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:327-35. 2011
  10. ncbi Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
    S Vujovic
    Wolfson Institute for Biomedical Research, University College London, and Department of Oral Pathology, King s College London Dental Institute at Guy s Hospital, WC1E 6BT, UK
    J Pathol 209:157-65. 2006

Research Grants

  1. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
  2. Role of Linker Histone H1 Variants in Cardiac Phenotype in Health and Disease
    Michelle Parvatiyar; Fiscal Year: 2012
  3. COBRE: RIH:CORE A: ADMINISTRATION &CAREER DVMT
    DOUGLAS CARTER HIXSON; Fiscal Year: 2011
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
  6. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
  7. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
  8. The Molecular Basis of Cadherin Adhesion
    Deborah Leckband; Fiscal Year: 2006
  9. Elucidate C. elegans Oxygen Sensing with Microfluidics
    Hang Lu; Fiscal Year: 2006
  10. Neurohormonal Effects of Massage Therapy
    Tiffany Field; Fiscal Year: 2007

Detail Information

Publications244 found, 100 shown here

  1. ncbi An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma
    Andrew C Nelson
    Randall Division of Cell and Molecular Biophysics, New Hunt s House, King s College London, Guy s Campus, London, SE1 1UL, UK
    J Pathol 228:274-85. 2012
    ....
  2. ncbi Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
    J C Corbo
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Development 124:589-602. 1997
    ..We discuss the implications of this analysis with regard to the evolutionary conservation of integrative enhancers, and the subdivision of the axial and paraxial mesoderm in vertebrates...
  3. ncbi BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
    Debalina Sarkar
    North West Cancer Research Fund Institute, School of Biological Sciences, Bangor University, Bangor, Gwynedd, United Kingdom
    Int J Cancer 130:328-37. 2012
    ..We suggest that BRACHYURY may regulate NANOG in mesenchymal-like CRC cells to impose a 'plastic-state', allowing competence of cells to respond to signals prompting invasion or metastasis...
  4. pmc T (brachyury) gene duplication confers major susceptibility to familial chordoma
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Nat Genet 41:1176-8. 2009
    ..Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes...
  5. pmc The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
    Romaine I Fernando
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:533-44. 2010
    ..The selective expression of Brachyury in tumor cells and its role in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor therapies...
  6. pmc Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
    Mario Roselli
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
    Clin Cancer Res 18:3868-79. 2012
    ..The T-box transcription factor Brachyury has been recently characterized as a driver of EMT in human carcinoma cells. The purpose of this study was to characterize Brachyury as a potential target for lung cancer therapy...
  7. ncbi Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis
    Stephane Romero
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Cell 119:419-29. 2004
    ..We successfully reconstitute formin-induced motility in vitro, demonstrating that this mechanism accounts for the puzzlingly rapid formin-induced actin processes observed in vivo...
  8. ncbi Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases
    Nirmala A Jambhekar
    Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
    Arch Pathol Lab Med 134:1181-7. 2010
    ..At times, it presents a diagnostic challenge, especially in small biopsies. Brachyury, a nuclear transcription factor, is a recently described immunohistochemical marker for diagnosing chordomas...
  9. ncbi Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study
    Nadege Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:327-35. 2011
    ..In conclusion, chromosomal aberrations resulting in gain of the T locus are common in sporadic chordomas and expression of this gene is critical for proliferation of chordoma cells in vitro...
  10. ncbi Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
    S Vujovic
    Wolfson Institute for Biomedical Research, University College London, and Department of Oral Pathology, King s College London Dental Institute at Guy s Hospital, WC1E 6BT, UK
    J Pathol 209:157-65. 2006
    ..These data provide compelling evidence that chordomas derive from notochord and demonstrate that brachyury is a specific marker for the notochord and notochord-derived tumours...
  11. pmc T-box genes in early embryogenesis
    Chris Showell
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dev Dyn 229:201-18. 2004
    ..Developmental Dynamics 229:201-218, 2004...
  12. pmc The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA
    Dev Dyn 240:1793-805. 2011
    ..We found that Ciona Brachyury regulates the expression of most, although not all, of these genes. These results shed light on the genetic regulatory program underlying notochord formation in Ciona and possibly other chordates...
  13. ncbi Brachyury expression predicts poor prognosis at early stages of colorectal cancer
    Nerbil Kilic
    Department of Internal Medicine II Oncology Haematology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr, Germany
    Eur J Cancer 47:1080-5. 2011
    ..Hence a subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry...
  14. pmc Cancer vaccines targeting the epithelial-mesenchymal transition: tissue distribution of brachyury and other drivers of the mesenchymal-like phenotype of carcinomas
    Duane H Hamilton
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Oncol 39:358-66. 2012
    ..We thus propose Brachyury as an attractive target for vaccination strategies designed to specifically target tumor cells undergoing EMT...
  15. ncbi Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features
    Christof Bernemann
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse, Munster, Germany
    Stem Cells 29:1496-503. 2011
    ....
  16. pmc A gene regulatory network directed by zebrafish No tail accounts for its roles in mesoderm formation
    Rosalind H Morley
    Department of Physiology, Development and Neuroscience, Cambridge University, Anatomy Building, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 106:3829-34. 2009
    ..Using our genome-scale data we have assembled a preliminary gene regulatory network that begins to describe mesoderm formation and patterning in the early zebrafish embryo...
  17. ncbi Unleashing formins to remodel the actin and microtubule cytoskeletons
    Melissa A Chesarone
    Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Mol Cell Biol 11:62-74. 2010
    ..The emerging complexity in the mechanisms governing formins mirrors the wide range of essential functions that they perform in cell motility, cell division and cell and tissue morphogenesis...
  18. pmc The Brachyury gene encodes a novel DNA binding protein
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
    EMBO J 12:3211-20. 1993
    ..The latter proteins also recognize the consensus DNA binding site. We suggest that the T protein is involved in the control of genes required for mesoderm formation, and for the differentiation and function of chorda mesoderm...
  19. pmc T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
    T P Yamaguchi
    Department of Molecular Biology, Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:3185-90. 1999
    ..Our results suggest that Wnt3a, signaling via Brachyury, modulates a balance between mesodermal and neural cell fates during gastrulation...
  20. ncbi Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
    C W Muller
    European Molecular Biology Laboratory, Grenoble Outstation, France
    Nature 389:884-8. 1997
    ..Thus the structure of this T domain complex with DNA reveals a new way in which a protein can recognize DNA...
  21. pmc Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells
    Amanda L Evans
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e33346. 2012
    ..Work in the frog and the zebrafish has identified some direct genomic targets of Brachyury, but little is known about Brachyury targets in the mouse...
  22. pmc XMAP215 is a processive microtubule polymerase
    Gary J Brouhard
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Cell 132:79-88. 2008
    ..The similarities between XMAP215 and formins, actin polymerases, suggest that processive tip tracking is a common mechanism for stimulating the growth of cytoskeletal polymers...
  23. ncbi The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy
    Claudia Palena
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:2471-8. 2007
    ..Particularly attractive targets are those molecules that are selectively expressed by malignant cells and that are also essential for tumor progression...
  24. pmc Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells
    Jungmook Lyu
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Res 21:911-21. 2011
    ..These results suggest that the Smek-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance...
  25. pmc Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression
    J Galceran
    Gene Center and Institute of Biochemistry, University of Munich, Feodor Lynenstrasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 98:8668-73. 2001
    ..Together, these data provide genetic evidence that Lef1 mediates the Wnt3a signal and regulates the stable maintenance of Brachyury expression during gastrulation...
  26. ncbi The T-box gene family
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Bioessays 20:9-19. 1998
    ..This review presents a current overview of progress made in the analysis of T-box genes and their products in a variety of model systems...
  27. ncbi Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation
    D Clements
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Mech Dev 56:139-49. 1996
    ..Additionally, the data suggest the possibility that axial and non-axial mesoderm are distinct from the earliest stages of Brachyury expression...
  28. pmc From notochord formation to hereditary chordoma: the many roles of Brachyury
    Yutaka Nibu
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Biomed Res Int 2013:826435. 2013
    ..In particular, we report on the current knowledge of the role of Brachyury and of its possible mechanisms of action in both notochord formation and chordoma etiogenesis...
  29. ncbi A common single-nucleotide variant in T is strongly associated with chordoma
    Nischalan Pillay
    Cancer Institute, University College London, UK
    Nat Genet 44:1185-7. 2012
    ..1, 95% confidence interval (CI) = 3.1-12.1; P = 4.4 × 10(-9)), a finding that is exceptional in cancers with a non-Mendelian mode of inheritance...
  30. ncbi Expression of brachyury in hemangioblastoma: potential use in differential diagnosis
    Valeria Barresi
    Department of Human Pathology, University of Messina, Messina, Italy
    Am J Surg Pathol 36:1052-7. 2012
    ..On the basis of our findings we propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of HBL toward histologic mimics...
  31. ncbi T-box genes: what they do and how they do it
    J Smith
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK NW7 1AA
    Trends Genet 15:154-8. 1999
    ..An understanding of how the T-box genes act requires analysis of how their expression is controlled, identification of their target genes, and an insight into how different family members exert different effects...
  32. ncbi The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation
    Antje Schulte
    Abteilung Physikalische Biochemie, Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Structure 16:1313-23. 2008
    ..Mutation of one residue in the predicted DAD-interaction surface efficiently activates FHOD1 in cells. These results demonstrate that DRFs have evolved different molecular solutions to govern their autoregulation and GTPase specificity...
  33. ncbi Brachyury, the blastopore and the evolution of the mesoderm
    U Technau
    Molecular Cell Biology, Institute for Zoology, Darmstadt University of Technology, Schnittspahnstr 10, 64287 Darmstadt, Germany
    Bioessays 23:788-94. 2001
    ..A subset of blastoporal cells expressing Brachyury and other genes that convey specific mesodermal functions may have segregated as a distinct cell population from this region in the course of mesoderm evolution...
  34. ncbi Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism
    Judith E Gasteier
    Institute for Hygiene, Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    J Biol Chem 278:38902-12. 2003
    ..These results indicate that FHOD1 acts as an effector of Rac in actin rearrangements and transcriptional regulation and may provide a link for the Rac-dependent activation of the Rho cascade...
  35. ncbi The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing
    Sebastian Hannemann
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    J Biol Chem 283:27891-903. 2008
    ..These results define a role for endogenous FHOD1 in SH4 domain-induced blebbing and suggest that its activity is regulated by ROCK1 in a Src-dependent manner...
  36. pmc The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    EMBO J 27:618-28. 2008
    ....
  37. ncbi Expression of the Brachyury gene during mesoderm development in differentiating embryonal carcinoma cell cultures
    G Vidricaire
    Department of Medicine, University of Ottawa, Canada
    Development 120:115-22. 1994
    ..Aggregated D3 cells express Brachyury mRNA suggesting that the mutation(s) responsible for the phenotype of D3 cells is downstream of the chain of events initiated by Brachyury expression...
  38. pmc Formins and microtubules
    F Bartolini
    Department of Pathology and Cell Biology, Columbia University, New York, NY, USA
    Biochim Biophys Acta 1803:164-73. 2010
    ....
  39. pmc The T protein encoded by Brachyury is a tissue-specific transcription factor
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    EMBO J 14:4763-72. 1995
    ..T can also transactivate transcription through variously oriented and spaced T sites, a fact that may be relevant in the search for genes controlled by T protein and important in mesoderm development...
  40. ncbi Mechanism and function of formins in the control of actin assembly
    Bruce L Goode
    Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    Annu Rev Biochem 76:593-627. 2007
    ..Other classes of formins lack the autoinhibitory and/or Rho-binding domains and thus are likely to be controlled by alternative mechanisms...
  41. ncbi Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity
    Pim C Lunter
    Department of Biochemistry 161, Nijmegen Center of Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Cancer Res 65:8801-8. 2005
    ..These data attribute a novel signaling role to ALCAM in regulation of proteolysis and support its previously postulated sensor function in invasive growth...
  42. pmc The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies
    B Huang
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Death Dis 4:e682. 2013
    ..Altogether, these results suggest that Brachyury expression may attenuate cell cycle progression, enabling tumor cells to become less susceptible to chemotherapy and radiation in human carcinomas. ..
  43. ncbi The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)
    Corinna B Scholz
    Molecular Cell Biology, Institute of Zoology, Darmstadt University of Technology, Schnittspahnstrasse 10, 64287 Darmstadt, Germany
    Dev Genes Evol 212:563-70. 2003
    ..We conclude that the ancestral function of Brachyury was in specifying the blastopore and its endodermal derivatives...
  44. ncbi How was the notochord born?
    Nori Satoh
    Marine Genomics Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan
    Evol Dev 14:56-75. 2012
    ....
  45. ncbi Temporal expression patterns of 39 Brachyury-downstream genes associated with notochord formation in the Ciona intestinalis embryo
    K Hotta
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Growth Differ 41:657-64. 1999
    ..These gene activities may be associated with changes in cell shape and adhesion during the intercalation and extension of the notochord cells...
  46. ncbi Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1
    André Schönichen
    Max Planck Institute for Molecular Physiology, Department of Physical Biochemistry, D 44227 Dortmund, Germany
    J Biol Chem 281:5084-93. 2006
    ....
  47. ncbi Determinants of T box protein specificity
    F L Conlon
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3749-58. 2001
    ..Mutation of this amino acid to lysine changes the inductive abilities of VegT and Eomesodermin to resemble that of Xbra...
  48. ncbi FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers
    André Schönichen
    Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany
    J Cell Sci 126:1891-901. 2013
    ....
  49. ncbi Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation
    Roberto Tirabosco
    Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 36:59-65. 2007
    ..Brachyury can be employed as a marker of notochordal differentiation and help identify confidently, for the first time, extra-axial bone and soft tissue chordomas, and tumours which may show focal notochordal differentiation...
  50. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..We propose that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak...
  51. ncbi Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities
    Ricardo Madrid
    Department of Infectious Diseases, Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Paris V, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    FEBS Lett 579:441-8. 2005
    ..Together, these results indicate that oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities...
  52. ncbi Highly conserved functions of the Brachyury gene on morphogenetic movements: insight from the early-diverging phylum Ctenophora
    Atsuko Yamada
    Department of Natural History Sciences, Faculty of Science, Hokkaido University, N10 W8, Kita ku, Sapporo, Hokkaido 060 0810, Japan
    Dev Biol 339:212-22. 2010
    ....
  53. ncbi In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome
    Tracie Pennimpede
    Max Planck Institute for Molecular Genetics, Developmental Genetics Department, Ihnestraße 73, 14195 Berlin, Germany
    Dev Biol 372:55-67. 2012
    ..Since KD3-T animals survive until birth, they are useful for examining later roles for T in the development of urorectal tissues...
  54. pmc Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 140:2422-33. 2013
    ..This work sheds light on a large section of the notochord regulatory circuitry controlled by T-box factors, and reveals new components of the complement of genes required for the proper formation of this structure...
  55. ncbi Interaction of goosecoid and brachyury in Xenopus mesoderm patterning
    M Artinger
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine 92697 2300, USA
    Mech Dev 65:187-96. 1997
    ....
  56. ncbi Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients
    Michael Tachezy
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    J Surg Res 177:e15-20. 2012
    ..Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival...
  57. ncbi The T genes in embryogenesis
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Trends Genet 10:280-6. 1994
    ..Homologous genes have been cloned from the frog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian Halocynthia roretzi. The T gene is an important tool for elucidating mesoderman and embryonic pattern formation...
  58. pmc Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables
    Agnieszka Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021 6399, USA
    Nat Cell Biol 6:21-30. 2004
    ..These findings provide new insight into how alpha-catenin orchestrates actin dynamics during intercellular junction formation...
  59. ncbi The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27
    Y H Edwards
    Human Biochemical Genetics Unit, University College London, England
    Genome Res 6:226-33. 1996
    ..The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene family to be described...
  60. ncbi Tales of tails: Brachyury and the T-box genes
    A I Kavka
    Dana Farber Cancer Institute, Boston, MA 02215, USA
    Biochim Biophys Acta 1333:F73-84. 1997
  61. ncbi Cancer stem cell sorting from colorectal cancer cell lines by sedimentation field flow fractionation
    Carole Mélin
    Institut 145 GEIST, EA 3842 Homeostasie Cellulaire et Pathologies, Faculte de Medecine, Universite de Limoges, 2 rue du Dr Marcland, 87025 Limoges Cedex, France
    Anal Chem 84:1549-56. 2012
    ..These results suggest, according to the literature, that two different pools of CSCs exist, quiescent and activated, which can both be sorted by SdFFF. Moreover, according to CSC properties, enriched fractions are able to form colonies...
  62. pmc Concerted action of two formins in gliding motility and host cell invasion by Toxoplasma gondii
    Wassim Daher
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland
    PLoS Pathog 6:e1001132. 2010
    ..These findings provide new insights into how controlled actin polymerization drives the directional movement required for productive penetration of parasites into host cells...
  63. ncbi Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Genes Dev 8:2137-50. 1994
    ..This conservation and the high similarity of T and Trg raise the question of a common evolutionary origin of the hindgut of insects and the notochord of chordates...
  64. pmc Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8
    V Cunliffe
    Laboratory of Developmental Biology, National Institute for Medical Research, Ridgeway, Mill Hill, London, UK
    EMBO J 13:349-59. 1994
    ....
  65. ncbi Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus
    B V Latinkic
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK ac uk
    Development 126:1769-79. 1999
    ..Goosecoid, a transcriptional repressor, appears to act directly on transcription of Xbra. In contrast, Mix.1, which functions as a transcriptional activator, may act on Xbra indirectly, in part through activation of goosecoid...
  66. ncbi Patterning of the mesoderm in Xenopus: dose-dependent and synergistic effects of Brachyury and Pintallavis
    M A O'Reilly
    Laboratory of Developmental Biology, National Institute for Medical Research, London, UK
    Development 121:1351-9. 1995
    ..These results suggest that Pintallavis cooperates with Brachyury to pattern the mesoderm in Xenopus...
  67. pmc Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer
    Vathany Kulasingam
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Int J Cancer 125:9-14. 2009
    ..05). Combining CA15-3 and ALCAM yielded a ROC curve with an AUC of 0.81 (95% CI [0.75, 0.87]). Serum ALCAM appears to be a new biomarker for breast cancer and may have value for disease diagnosis...
  68. pmc Teasing out T-box targets in early mesoderm
    Fiona C Wardle
    Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK
    Curr Opin Genet Dev 18:418-25. 2008
    ....
  69. pmc Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 136:3679-89. 2009
    ....
  70. ncbi Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target
    Wesley Hsu
    Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Neurosurg 115:760-9. 2011
    ..Thus, the objective of this study was to establish the first fully characterized primary chordoma cell line expressing gain of the T gene locus that readily recapitulates the original parental tumor phenotype in vitro and in vivo...
  71. pmc Brachyury establishes the embryonic mesodermal progenitor niche
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 24:2778-83. 2010
    ..Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells...
  72. ncbi Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients
    Meenakshi Sawhney
    Department of Biochemistry, Institute of Rotary Cancer Hospital, All India Institute for Medical Sciences, Ansari Nagar, New Delhi, India
    Int J Cancer 124:2098-105. 2009
    ....
  73. ncbi ALCAM (CD166) expression as novel prognostic biomarker for pancreatic neuroendocrine tumor patients
    Michael Tachezy
    Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Surg Res 170:226-32. 2011
    ..The aim of this study was to determine the expression of ALCAM in PNET to learn more about the prevalence and clinical significance of ALCAM expression in PNET...
  74. ncbi Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
    Adam H Hart
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
    Development 129:3597-608. 2002
    ..Mixl1 is therefore required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis...
  75. pmc Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage
    Andrew D Johnson
    Department of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Philos Trans R Soc Lond B Biol Sci 358:1371-9. 2003
    ..Our results imply that germ plasm, as found in species such as frogs and teleosts, is the result of convergent evolution. We discuss the evolutionary implications of our findings...
  76. ncbi Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1
    Suzan Abu-Abed
    Cancer Research Labs, Queen s University, Kingston, ON K7L 3N6, Canada
    Development 130:1449-59. 2003
    ....
  77. pmc Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer
    Bhaumik B Patel
    Veterans Administration Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Biochem Biophys Res Commun 378:344-7. 2009
    ..Moreover, our observation of the age-related rise in CSC in macroscopically normal colonic mucosa suggests a predisposition of the organ to developing colorectal cancer...
  78. ncbi Comparative study of SPR and ELISA methods based on analysis of CD166/ALCAM levels in cancer and control human sera
    Hana Vaisocherová
    Department of Chemical Engineering, University of Washington, Seattle, WA 98195 1750, USA
    Biosens Bioelectron 24:2143-8. 2009
    ..It is demonstrated that SPR can distinguish between ALCAM levels in cancer and control sera using direct detection without the need for additional amplification steps...
  79. ncbi Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients
    Delia Mezzanzanica
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 14:1726-33. 2008
    ..In a retrospective study, we investigated the prognostic impact of activated leukocyte cell adhesion molecule (ALCAM) expression in epithelial ovarian cancer...
  80. ncbi The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis
    Yongquan Shi
    Department of Medicine, Samuel Lunenfeld and Toronto Hospital Research Institutes, University of Toronto, Toronto, Canada
    J Immunol 182:3837-45. 2009
    ..Thus, mDia1 roles in neutrophil chemotaxis appear to be subserved in concert with WASp and are realized at least in part by activation of the LARG/RhoA/ROCK signaling pathway...
  81. ncbi The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm
    G Carnac
    Wellcome CRC Institute, Cambridge, United Kingdom
    Development 122:3055-65. 1996
    ..Hence, in the absence of mesoderm induction, overexpression of Siamois is sufficient to confer organiser properties on embryonic cells...
  82. ncbi Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution
    Kohji Hotta
    Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Evol Dev 10:37-51. 2008
    ..We propose that Brachyury is linked to these pathways regulating the expression of each component, and such a regulatory mechanism might be conserved among chordates...
  83. ncbi Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
    M Tada
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 125:3997-4006. 1998
    ..These results suggest that Bix1 acts downstream of both VegT and Xbra to induce formation of mesoderm and endoderm...
  84. ncbi Altered splicing pattern of TACC1 mRNA in gastric cancer
    Aija Line
    Biomedical Research and Study Center, University of Latvia, Riga, Latvia
    Cancer Genet Cytogenet 139:78-83. 2002
    ..We also propose that inappropriate expression of the isoforms in gastric cancer cells might result in dysfunction of TACC1 thus contributing to the genetic instability...
  85. ncbi Development of definitive endoderm from embryonic stem cells in culture
    Atsushi Kubo
    The Carl C Icahn Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 131:1651-62. 2004
    ..These findings demonstrate that ES cells can generate endoderm in culture and, as such, establish this differentiation system as a unique murine model for studying the development and specification of this germ layer...
  86. ncbi Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators
    Nathalie Conte
    Département d Oncologie Moléculaire, U119 INSERM, 27 Bd Lei Roure, 13009, Marseille, France
    Oncogene 21:5619-30. 2002
    ..We speculate that down-regulation of TACC1 may alter the control of mRNA homeostasis in polarized cells and participates in the oncogenic processes...
  87. pmc The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord
    Matthew P Dunn
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Dev Biol 328:561-74. 2009
    ..Together, these observations provide mechanistic insights generally applicable to T-box transcription factors and their target sequences, as well as a first set of clues on the function of Leprecan in early chordate development...
  88. pmc Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion
    Thomas Kusch
    Institut fur Genetik, Universitat zu Koln, 50931 Koln, Germany
    Genes Dev 16:518-29. 2002
    ..We propose that the mechanisms to achieve target gene expression through variable binding sites and through defined protein-protein interactions might be conserved for Brachyury relatives...
  89. ncbi Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics
    Jennifer J Westendorf
    The Cancer Center and Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    J Cell Biochem 92:29-41. 2004
    ..Thus, the identification of a new FHOD1-binding protein provides insight into the mechanisms by which FHOD1 regulates actin polymerization and transcription...
  90. pmc Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury
    Jiang I Wu
    Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas 78712 1064, USA
    Genetics 177:1151-61. 2007
    ..Surprisingly, tint interacts with T2 but not with T1. The implications of our data suggest that T2 may be part of the T1 regulatory region through direct or indirect participation of tint...
  91. ncbi Low activated leukocyte cell adhesion molecule expression is associated with advanced tumor stage and early prostate-specific antigen relapse in prostate cancer
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Pathol 42:1946-52. 2011
    ..The abundant presence of activated leukocyte cell adhesion molecule and its membranous localization in prostate cancer epithelium make activated leukocyte cell adhesion molecule a potentially attractive structure for targeted therapy...
  92. ncbi T promoter activity in the absence of functional T protein during axis formation and elongation in the mouse
    C Schmidt
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Dev Biol 189:161-73. 1997
    ..Therefore, we suggest that a direct FGF and T autoregulatory loop is unlikely to operate during gastrulation and axis elongation in the mouse...
  93. ncbi The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells
    Ombretta Rosso
    Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Mol Cancer Res 5:1246-53. 2007
    ..Altogether, our data suggest that the disruption of ALCAM-mediated adhesion is a relevant step in EOC motility, and ADAM17/TACE takes part in this process, which may be relevant to EOC invasive potential...
  94. pmc The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway
    F Panitz
    Institut für und Molekulare Zellbiologie, Universitat Gottingen, Germany
    EMBO J 17:4414-25. 1998
    ..These findings define a cascade of events that links Xbra activity to the signal-regulated control of Xegr-1 transcription in the context of early mesoderm induction in Xenopus laevis...
  95. ncbi Congenital disorder of glycosylation type Id: clinical phenotype, molecular analysis, prenatal diagnosis, and glycosylation of fetal proteins
    Jonas Denecke
    Department of Pediatrics, University Hospital of Munster, 48149 Munster, Germany
    Pediatr Res 58:248-53. 2005
    ..Maternal or placental factors that partially compensate for the glycosylation defect in the fetal stage must be proposed and may be relevant for the therapy of these disorders in the future...
  96. pmc Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation
    Markus Dettenhofer
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2497. 2008
    ..Thus, formins are predicted to contribute to several important cell processes such as locomotion, membrane ruffling, vesicle endocytosis, and stress fiber formation and disassociation...
  97. ncbi The TACC proteins: TACC-ling microtubule dynamics and centrosome function
    Isabel Peset
    Cell and Developmental Biology Program, Centre for Genomic Regulation CRG, university pompeu fabra UPF, Dr Aiguader 88, Barcelona 08003, Spain
    Trends Cell Biol 18:379-88. 2008
    ..Here, we review the current understanding of the role of TACC proteins in the regulation of microtubule dynamics, and we highlight the complexity of centrosome function...
  98. ncbi Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis
    Mireia Garriga-Canut
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 279:23597-605. 2004
    ....
  99. ncbi Formin-induced nucleation of actin filaments
    Sally H Zigmond
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Curr Opin Cell Biol 16:99-105. 2004
    ..The FH2 domain also binds to the filament's barbed end, modulating its elongation and protecting it from capping proteins. FH2 itself appears to be a processive cap that walks with the barbed end as it elongates...
  100. pmc Review of the mechanism of processive actin filament elongation by formins
    Aditya S Paul
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Cell Motil Cytoskeleton 66:606-17. 2009
    ..These biophysical insights provide the context to understand how formins contribute to actin assembly in cells. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc...
  101. ncbi Formin proteins: a domain-based approach
    Henry N Higgs
    Department of Biochemistry, Dartmouth Medical School, Hanover NH 03755, USA
    Trends Biochem Sci 30:342-53. 2005
    ..Other formins lack DAD, DID and GBD, and their regulatory mechanisms await elucidation...

Research Grants41

  1. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..of MBNL1 by polyCUG expansions or through genetic ablation of MBNL1 results in the inappropriate expression of fetal proteins in adult differentiated tissues (9, 14- 17)...
  2. Role of Linker Histone H1 Variants in Cardiac Phenotype in Health and Disease
    Michelle Parvatiyar; Fiscal Year: 2012
    ..The progression of disease leads to a variety of adaptive responses including the re-expression of fetal proteins. Despite advances in the knowledge of pathways that control hypertrophy, little is known about how modifiers ..
  3. COBRE: RIH:CORE A: ADMINISTRATION &CAREER DVMT
    DOUGLAS CARTER HIXSON; Fiscal Year: 2011
    ..represented by investigators pursuing research relevant to four major themes - Theme A - The significance of fetal proteins and phenotypes in Cancer;Theme B - Pathogenesis Of GI Tumors;Theme C - Signal Transduction Mechanisms Relevant ..
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
    ..Produce a conditional allele of Tbx4 to study gene function late in development. Specific Aim 3. Investigate regulatory and genetic interactions between the genes of the Tbx subfamily, Tbx2, Tbx3, Tbx4, and Tbx5. ..
  6. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
    ..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..
  7. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  8. The Molecular Basis of Cadherin Adhesion
    Deborah Leckband; Fiscal Year: 2006
    ..Together, these proposed investigations will provide a comprehensive analysis of cadherin function at an unprecedented level of detail, revealing both the underlying adhesive mechanisms and their structural origins. ..
  9. Elucidate C. elegans Oxygen Sensing with Microfluidics
    Hang Lu; Fiscal Year: 2006
    ..The general techniques developed in this study should impact other C. elegans researches of sensing and behaviors such as odor discrimination and thermo-sensation. ..
  10. Neurohormonal Effects of Massage Therapy
    Tiffany Field; Fiscal Year: 2007
    ..The K05 would allow me to increase my research time including being mentored and mentoring students from 25 to 75% time. [unreadable] [unreadable] [unreadable]..
  11. National Pharmacology Directors of Graduate Programs Meeting
    Joey Barnett; Fiscal Year: 2007
    ..A continuing dialogue among Directors of training programs and other scientists with an interest in training is identified as a desired major outcome. [unreadable] [unreadable] [unreadable]..
  12. Dissecting neural circuits by microfluidic-enabled rapid microscopy & ablation
    Hang Lu; Fiscal Year: 2008
    ..In addition, besides the contribution to C. elegans sensory biology, the technologies are widely applicable to areas such as developmental biology, and to other organisms. [unreadable] [unreadable]..
  13. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2008
    ..abstract_text> ..
  14. INSECTICIDE ACTIONS ON GABA-A RECEPTORS
    Gustav Akk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. FUNCTION OF CX43-INTERACTING PROTEINS IN NEURAL CREST MIGRATION
    ROBERT GOURDIE; Fiscal Year: 2009
    ..This study will provide new insight into molecular regulation of neural crest migration in the embryo and origins of birth defects in humans.; ..
  16. Mechanisms of Atherosclerosis and CVD in HIV+ Women
    Robert Kaplan; Fiscal Year: 2009
    ..This investigation will have major implications for the development of strategies to predict, prevent, or reverse atherosclerosis in HIV- infected women. ..
  17. Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA Study
    Lisa A Croen; Fiscal Year: 2010
    ..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
  18. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
    ....
  19. STRUCTURE, FUNCTION AND EXPRESSION OF TYPE XV COLLAGEN
    JEANNE MYERS; Fiscal Year: 2001
    ..The organization and structure of type XV collagen and the molecules with whom it interacts will elucidate their involvement in inherited diseases of connective tissue and other pathologic processes. ..
  20. A New Collagen Expressed Primarily in Brain Tissue
    JEANNE MYERS; Fiscal Year: 2002
    ..The highly unusual tissue representation of Collagen B presents a unique opportunity for future elucidation of its role in CNS development, and in neuropathological conditions that will become increasingly prevalent in an aging society. ..
  21. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    ..Finally, gene targeting in the mouse will be used to study the biological activities of Mga and the individual roles of its bHLHZip domain and T-domain. ..
  22. Force Probe Investigations of NCAM Adhesion
    Deborah Leckband; Fiscal Year: 2004
    ....
  23. MOLECULAR CHARACTERIZATION OF TYPE XIX COLLAGEN
    JEANNE MYERS; Fiscal Year: 2005
    ..The experiments proposed here will significantly advance understanding of a collagen manifested in seemingly different roles in adult tissue BMZ, and in the myogenic pathway evidenced in RMS and muscle regeneration. ..
  24. Anti-Cancer Drugs that Target Diaphanous-related Formins
    ARTHUR ALBERTS; Fiscal Year: 2005
    ..abstract_text> ..
  25. Cardiac Pacemaking and Conduction System Symposium
    ROBERT GOURDIE; Fiscal Year: 2004
    ..A website on the "cardiac pacemaking and conduction system" will be established at Medical University of South Carolina with content arising from work presented and published from the meeting. ..
  26. EM & TIRF analysis of Arp2/3 complex and actin assembly
    BRUCE GOODE; Fiscal Year: 2008
    ..The PI will be directly involved in the integration of TIRF microscopy and single particle imaging into his research program. ..
  27. Massaging Preterm Infants Enhances Growth
    Tiffany Field; Fiscal Year: 2006
    ..abstract_text> ..
  28. Restoration of Skin Structure and Function Post-Wounding
    ROBERT GOURDIE; Fiscal Year: 2006
    ..It is FSR's overall objective to develop its peptide into a pharmaceutically acceptable topical agent for application to surgical and non-surgical skin wounds in humans. [unreadable] [unreadable] [unreadable]..
  29. Actions of Ethanol on Ligand-Gated Ion Channels
    Gustav Akk; Fiscal Year: 2006
    ..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
  30. Epidemiology of IGF and Cardiovascular Events
    Robert Kaplan; Fiscal Year: 2005
    ....
  31. Prenatal Depression and a Yoga Intervention
    Tiffany M Field; Fiscal Year: 2010
    ..We would expect that yoga would decrease depression, increase vagal activity, decrease cortisol and increase gestational age (decrease prematurity). ..
  32. TGFB RECEPTOR EXPRESSION AND FUNCTION IN CARDIOGENESIS
    Joey Barnett; Fiscal Year: 2005
    ..Our long-term goal to understand the role of TGFbeta in cushion transformation and the genesis of congenital heart defects due to abnormal cushion transformation. ..
  33. Design of a light-switched, genetically-encoded regulator of actin assembly
    BRUCE GOODE; Fiscal Year: 2008
    ..We are proposing to develop new research tools to better understand the function of this protein and to help develop cures for the diseases caused by its malfunction. [unreadable] [unreadable] [unreadable]..
  34. TRAINING PROGRAM IN CARDIOVASCULAR PHARMACOLOGY
    Joey Barnett; Fiscal Year: 2008
    ..Our overall goal is to train scientists who will be leaders in academia, industry, or regulatory affairs. ..
  35. Patterning by Invasive Mesenchyme in the Embryonic Heart
    ROBERT GOURDIE; Fiscal Year: 2005
    ..abstract_text> ..
  36. Prenatal and Neonatal Biologic Markers for Autism
    Lisa Croen; Fiscal Year: 2006
    ..abstract_text> ..
  37. Function of VirK and MsbB2 in Shigella pathogenesis
    MARCIA GOLDBERG; Fiscal Year: 2006
    ..These exploratory studies are highly likely to result in specific testable hypotheses that are relevant to disease. [unreadable] [unreadable] [unreadable]..
  38. Autotrasporter periplasmic chaperones in Shigella
    MARCIA GOLDBERG; Fiscal Year: 2005
    ..These exploratory studies are highly likely to result in additional specific testable hypotheses relevant to disease caused by this Category B Priority Pathogen. ..
  39. Shiga toxin-encoding phage adsorption and toxin release
    MARCIA GOLDBERG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2006
    ..These studies will contribute to our understanding of the gene regulatory networks that control craniofacial development, and of how disruption of these networks result in craniofacial defects. [unreadable] [unreadable]..