ccaat enhancer binding protein beta

Summary

Summary: A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.

Top Publications

  1. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
  2. pmc TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity
    Olivier Bezy
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 27:6818-31. 2007
  3. pmc Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis
    Qi Qun Tang
    Departments of Pediatrics Division of Endocrinology, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:9766-71. 2005
  4. ncbi CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation
    Krisztián A Kovács
    Department of Child and Adolescent Psychiatry, University of Lausanne, CH 1005 Lausanne, Switzerland
    J Biol Chem 278:36959-65. 2003
  5. ncbi A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation
    C A Zahnow
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 61:261-9. 2001
  6. ncbi Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 168:5811-6. 2002
  7. pmc C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)
    S J Ewing
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Cell Death Differ 15:1734-44. 2008
  8. pmc Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
    M Buck
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 20:6712-23. 2001
  9. pmc Misexpression of CCAAT/enhancer binding protein beta causes osteopenia
    Stefano Zanotti
    Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105 1299, USA
    J Endocrinol 201:263-74. 2009
  10. ncbi Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromatase
    Sijun Yang
    Department of Obstetrics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:2336-45. 2002

Research Grants

Detail Information

Publications240 found, 100 shown here

  1. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
    ..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis)...
  2. pmc TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity
    Olivier Bezy
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 27:6818-31. 2007
    ..Thus, TRB3 is an important negative regulator of adipogenesis that acts at an early step in the differentiation cascade to block the C/EBPbeta proadipogenic function...
  3. pmc Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis
    Qi Qun Tang
    Departments of Pediatrics Division of Endocrinology, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:9766-71. 2005
    ..The delayed transactivation of the C/EBPalpha and PPARgamma genes by C/EBPbeta appears necessary to allow mitotic clonal expansion, which would otherwise be prevented, because C/EBPalpha and PPARgamma are antimitotic...
  4. ncbi CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation
    Krisztián A Kovács
    Department of Child and Adolescent Psychiatry, University of Lausanne, CH 1005 Lausanne, Switzerland
    J Biol Chem 278:36959-65. 2003
    ....
  5. ncbi A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation
    C A Zahnow
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 61:261-9. 2001
    ....
  6. ncbi Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 168:5811-6. 2002
    ..Thus, mPGES is critically involved in the biosynthesis of PGE(2) induced by LPS, but is dispensable for the modulation of inflammatory responses...
  7. pmc C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)
    S J Ewing
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Cell Death Differ 15:1734-44. 2008
    ....
  8. pmc Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
    M Buck
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 20:6712-23. 2001
    ..Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression...
  9. pmc Misexpression of CCAAT/enhancer binding protein beta causes osteopenia
    Stefano Zanotti
    Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105 1299, USA
    J Endocrinol 201:263-74. 2009
    ..In conclusion, C/EBP beta plays a role in mesenchymal cell differentiation and its misexpression in vivo causes osteopenia...
  10. ncbi Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromatase
    Sijun Yang
    Department of Obstetrics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:2336-45. 2002
    ..In vivo down-regulation of C/EBPbeta in endometriotic stromal cells and its up-regulation in endometrial stromal cells may in part account for the induction of P450arom expression in endometriosis and its inhibition in endometrium...
  11. pmc Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
    Wen Ling Wang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    Nucleic Acids Res 36:6066-79. 2008
    ..In light of the above, our data suggest that the suCEBPD and suLAP1 are involved in the repression of COX-2 transcription through the recruitment of HDAC4...
  12. pmc C/EBPbeta is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma
    Srinivasa Raju Mantena
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:1870-5. 2006
    ..Collectively, our studies established that C/EBPbeta is a key mediator of steroid responsiveness of the epithelium and stroma in the mouse uterus...
  13. ncbi C/EBPbeta is required for 'emergency' granulopoiesis
    Hideyo Hirai
    Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 7:732-9. 2006
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  14. ncbi Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts
    M A Saunders
    Vascular Biology Research Center and Division of Hematology, University of Texas-Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 276:18897-904. 2001
    ..These findings have a major impact on the conceptual understanding of the mechanism of action of salicylates and on new drug discovery and design...
  15. ncbi Interferon-gamma induces C/EBP beta expression and activity through MEK/ERK and p38 in T84 colon epithelial cells
    Pertteli Salmenperä
    Department of Pharmacology, Institute of Biomedicine, FIN 00014 University of Helsinki, Finland
    Am J Physiol Cell Physiol 284:C1133-9. 2003
    ..These results suggest a role for MEK2 and p38 in IFN-gamma-mediated signal transduction and induction of C/EBP beta expression and activity associated with interleukin-6 (IL-6) secretion in colon epithelial cells...
  16. pmc CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling
    Songyun Zhu
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Proc Natl Acad Sci U S A 99:207-12. 2002
    ..These findings indicate that C/EBPbeta has a critical role in Ras-mediated tumorigenesis and cell survival and implicate C/EBPbeta as a target for tumor inhibition...
  17. ncbi Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:36301-9. 2005
    ..Collectively, these changes prevent C/EBPbeta-null mammary epithelial cells from responding to hormone-induced proliferative signals...
  18. pmc Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3
    Ewa Marcinkowska
    Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, 50 137 Wroclaw, Poland
    Exp Cell Res 312:2054-65. 2006
    ....
  19. ncbi C/EBP beta blocks p65 phosphorylation and thereby NF-kappa B-mediated transcription in TNF-tolerant cells
    Andreas Zwergal
    Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
    J Immunol 177:665-72. 2006
    ..These results define a new molecular mechanism responsible for TNF tolerance in monocytic cells that may contribute to the unresponsiveness seen in patients with sepsis...
  20. ncbi Dual regulation of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in response to growth hormone
    Graciela Piwien-Pilipuk
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 277:44557-65. 2002
    ....
  21. ncbi Prostaglandin E(2)-mediated activation of HIV-1 long terminal repeat transcription in human T cells necessitates CCAAT/enhancer binding protein (C/EBP) binding sites in addition to cooperative interactions between C/EBPbeta and cyclic adenosine 5'-monopho
    Nancy Dumais
    Centre de Recherche en Infectiologie, Hôpital CHUL, Centre Hospitalier Universitaire de Quebec, Ste Foy, Quebec, Canada G1V 4G2
    J Immunol 168:274-82. 2002
    ..Such a combinatorial regulation may represent a mechanism that permits a fine regulation of HIV-1 expression by PGE(2) in human T cells...
  22. ncbi The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204. 2003
    ..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
  23. ncbi Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model
    Sheila A Barber
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 193:963-70. 2006
    ..The brain is considered to be a reservoir of latent human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). We examined the mechanism by which innate immune responses contribute to the establishment of this reservoir...
  24. pmc MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 324:938-41. 2009
    ..Thus, ERK1/2 and C/EBPbeta constitute an in vivo LH-regulated signaling pathway that controls ovulation- and luteinization-related events...
  25. ncbi CUGBP1 is required for IFNbeta-mediated induction of dominant-negative CEBPbeta and suppression of SIV replication in macrophages
    Justyna M Dudaronek
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 179:7262-9. 2007
    ....
  26. ncbi Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms
    Zhu Chen
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 1:93-106. 2005
    ..These data indicate that Krox20 is necessary for adipogenesis and that, when overexpressed, Krox20 potently stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms...
  27. pmc Transcriptional regulation of adipogenesis by KLF4
    Kivanc Birsoy
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Cell Metab 7:339-47. 2008
    ..KLF4 is specifically induced in response to cAMP, which by itself can partially activate adipogenesis. These data suggest that KLF4 functions as an immediate early regulator of adipogenesis to induce C/EBPbeta...
  28. ncbi SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells
    Friederike Berberich-Siebelt
    Department of Molecular Pathology, University of Wuerzbrug, Germany
    J Immunol 176:4843-51. 2006
    ..These results suggest an important role of sumoylation in adjusting the finely tuned balance between proliferation and differentiation in peripheral T cells which is controlled by C/EBPbeta...
  29. pmc CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4
    Hiroyuki Tominaga
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Mol Biol Cell 19:5373-86. 2008
    ..Thus, our results provide evidence that C/EBPbeta is a crucial cofactor in the promotion of osteoblast maturation by Runx2 and ATF4...
  30. ncbi Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription
    TERESA I CESENA
    Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109 5622, United States
    Mol Cell Endocrinol 289:94-101. 2008
    ..These findings suggest that acetylation of C/EBPbeta at K39 is an important and dynamic regulatory event that contributes to its ability to transactivate target genes, including those associated with adipogenesis and adipocyte function...
  31. ncbi Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
    Jean Philippe Bastard
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, Paris, France
    Lancet 359:1026-31. 2002
    ..In-vitro studies show that HIV-1-protease inhibitors affect adipocyte differentiation at an early step involving sterol-regulatory-element-binding-protein-1 (SREBP1), but in-vivo studies are lacking...
  32. pmc Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells
    Jennifer Wessells
    Eukaryotic Transcriptional Regulation Section, Laboratory of Protein Dynamics and Signaling, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Mol Cell Biol 24:3238-50. 2004
    ..Thus, our findings demonstrate that C/EBP beta is essential for oncogenic transformation of macrophages and functions at least in part by regulating expression of the survival factor IGF-I...
  33. ncbi A critical role for C/EBPbeta binding to the AABS promoter response element in the human iNOS gene
    Zhong Guo
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    FASEB J 17:1718-20. 2003
    ..Further, C/EBPbeta binding to AABS functions as a "switchpoint" that is necessary for cytokine-inducible hiNOS gene expression in all cell types examined...
  34. ncbi ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma
    J Hu
    Greenebaum Cancer Center, Department of Microbiology and Immunology, Molecular and Cellular Biology Program, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:287-97. 2001
    ..A C/EBP-beta mutant lacking the ERK phosphorylation site failed to promote IFN-stimulated gene expression. Thus, our data link C/EBP-beta to IFN-gamma signaling through ERKs...
  35. ncbi McBindall--a better name for CCAAT/enhancer binding proteins?
    S L McKnight
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 107:259-61. 2001
    ..Three new studies give evidence that this regulation is mediated by protein:protein interactions completely distinct from the role of C/EBPs in gene expression...
  36. ncbi A transcriptional role for C/EBP beta in the neuronal response to axonal injury
    Sylvain Nadeau
    Developmental Biology and Neurobiology and Behavior, Hospital for Sick Children, 3203 Black Wing, Toronto, Ontario, Canada M5G 1X5
    Mol Cell Neurosci 29:525-35. 2005
    ..Thus, C/EBPbeta is essential for the neuronal injury response, acting to transcriptionally activate regeneration-associated gene expression...
  37. ncbi Interleukin-1 beta induction of matrix metalloproteinase-1 transcription in chondrocytes requires ERK-dependent activation of CCAAT enhancer-binding protein-beta
    Lauren Raymond
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Cell Physiol 207:683-8. 2006
    ..Our findings demonstrate a novel role for C/EBP-beta in IL-1beta-induced connective tissue disease and define a new nuclear target for the ERK pathway in MMP-1 gene activation...
  38. ncbi Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene
    Wen Chi Su
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei
    J Biol Chem 278:51150-8. 2003
    ..Our results indicate that LAP* is the primary isoform of C/EBP beta that regulates, through a redox switch, the LPS-induced expression of the IL-6 gene...
  39. ncbi Inhibition of p90 ribosomal S6 kinase-mediated CCAAT/enhancer-binding protein beta activation and cyclooxygenase-2 expression by salicylate
    Katarzyna A Cieslik
    Vascular Biology Research Center and Division of Hematology, Brown Foundation Institute of Molecular Medicine and Medical School, The University of Texas Health Science Center and Texas Heart Institute, Houston, Texas 77030 1503, USA
    J Biol Chem 280:18411-7. 2005
    ..We conclude that salicylate inhibits C/EBPbeta-mediated COX-2 transcriptional activation by blocking RSK activity and Ras signaling pathway...
  40. ncbi Sequential gene promoter interactions of C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis
    Qi Qun Tang
    Biological Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 319:235-9. 2004
    ..g., 422/aP2) in the terminally differentiated state. Together these findings provide compelling evidence that C/EBPbeta, C/EBPalpha, and PPARgamma participate in a cascade during adipogenesis...
  41. pmc CCAAT/enhancer binding protein-beta is a transcriptional regulator of peroxisome-proliferator-activated receptor-gamma coactivator-1alpha in the regenerating liver
    Haitao Wang
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Endocrinol 22:1596-605. 2008
    ..The demonstration of a functional link between C/EBPbeta and PGC-1alpha activation provides a likely mechanism for how upstream signaling pathways in the regenerating liver can enable the adaptation to the changed metabolic status...
  42. pmc Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites
    W Xiong
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0643, USA
    Nucleic Acids Res 29:3087-98. 2001
    ..We propose that formation of C/EBPbeta isoforms is accomplished by a leaky ribosomal scanning mechanism that facilitates ATI of multiple internal AUGs...
  43. pmc C/EBPbeta regulates body composition, energy balance-related hormones and tumor growth
    Jennifer Staiger
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Carcinogenesis 30:832-40. 2009
    ..Thus, C/EBPbeta contributes to endocrine expression of IGF-1, leptin and insulin, which modulate energy balance and can contribute to cancer progression by creating a favorable environment for tumor cell proliferation and survival...
  44. pmc Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB
    Jeske J Smink
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    EMBO J 28:1769-81. 2009
    ..These data show that mTOR regulates osteoclast formation by modulating the C/EBPbeta isoform ratio, which in turn affects osteoclastogenesis by regulating MafB expression...
  45. ncbi CCAAT/enhancer binding protein beta (C/EBPbeta)-2 transforms normal mammary epithelial cells and induces epithelial to mesenchymal transition in culture
    L M Bundy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Oncogene 22:869-83. 2003
    ..These studies, and our previous observations, provide supportive evidence that deregulated expression of C/EBPbeta-2 contributes to malignant conversion of the human breast...
  46. ncbi Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2
    Keith E Fox
    Research Service, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 281:40341-53. 2006
    ..The data also indicate that CREB not only functions during the initiation of adipogenic conversion but also at later stages...
  47. ncbi Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR
    Ding Gan Liu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 13:509-14. 2003
    ..Therefore, our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile...
  48. ncbi Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3
    Xin Zhao
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:32683-92. 2005
    ..We conclude that cGMP increases the DNA binding potential of C/EBPbeta by preventing the negative effects of GSK-3 phosphorylation...
  49. pmc Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Catalunya, Spain
    Biochem J 389:47-56. 2005
    ..In summary, defective thermoregulation owing to the lack of C/EBPbeta is associated with the reduced capacity to supply fatty acids as fuels to sustain brown fat thermogenesis...
  50. ncbi Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with induced adipocyte differentiation in mouse embryonic fibroblasts (MEFs) involves tyrosine kinase c-Src
    Christoph F A Vogel
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Biochem Pharmacol 66:1231-44. 2003
    ....
  51. ncbi Expression, hormonal regulation, and subcellular localization of CCAAT/enhancer-binding protein-beta in rat and human thyrocytes
    Martine Pomerance
    Institut National de la Santé et de la Recherche Médicale Université Paris XI, Faculte de Pharmacie, Chatenay Malabry, France
    Thyroid 15:197-204. 2005
    ..These data suggest that this factor may play important roles in the regulation of thyroidspecific genes and processes, and that its functions are altered in human thyroid carcinoma...
  52. pmc C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells
    Linda Bundy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cancer 4:43. 2005
    ..Ras signaling pathways are activated in mammary epithelial cells by the ErbB receptor tyrosine kinase family. Therefore, we considered whether elevated C/EBPbeta-2 expression would resemble ErbB RTK activation in MCF10A cells...
  53. pmc STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta
    Min Xu
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    EMBO J 22:893-904. 2003
    ..Thus, we propose a novel mechanism by which STAT5 mediates the deacetylation of C/EBPbeta, allowing transcriptional activation...
  54. pmc Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12
    Jon D Shuman
    Laboratory of Protein Dynamics and Signaling, NCI Frederick, Frederick, MD 21702 1201, USA
    Mol Cell Biol 24:7380-91. 2004
    ....
  55. ncbi ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor
    M Hanlon
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:38449-56. 2001
    ..Finally, we demonstrate a requirement for p90(Rsk2) in regulation of C/EBPbeta-SRF interaction. These data show that multiple Ras effectors are required to regulate C/EBPbeta and SRF association...
  56. pmc ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis
    Justin J Rochford
    Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 2QR, United Kingdom
    Mol Cell Biol 24:9863-72. 2004
    ..These findings define, for the first time, a molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta and a novel regulator of early adipogenesis...
  57. pmc The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis
    Robert L Kortum
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198 7696, USA
    Mol Cell Biol 25:7592-604. 2005
    ..Titration of KSR1 expression reveals how a molecular scaffold can modulate the intensity and duration of signaling emanating from a single pathway to dictate cell fate...
  58. ncbi Induction of granulocytic differentiation by 2 pathways
    Pu Zhang
    Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 99:4406-12. 2002
    ....
  59. ncbi C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages
    Barbara Gorgoni
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, Scotland
    J Immunol 168:4055-62. 2002
    ....
  60. ncbi C/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver
    Tom Luedde
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 40:356-65. 2004
    ..In the context of previous studies, our results demonstrate that LAP, through a dose-dependent effect, withholds a dual activating and inhibiting role on hepatocyte proliferation in vivo...
  61. pmc Essential requirement of CCAAT/enhancer binding proteins in embryogenesis
    Valerie Begay
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
    Mol Cell Biol 24:9744-51. 2004
    ..Our data thus reveal novel essential, redundant, and dosage dependent functions of C/EBPs...
  62. pmc C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages
    Michelle N Bradley
    Howard Hughes Medical Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095 1662, USA
    Mol Cell Biol 23:4841-58. 2003
    ....
  63. pmc Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
    Xiaojuan Liu
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 277:39312-9. 2002
    ..This study illustrates a novel role for HIV-1 tat in inducing the expression of iNOS in human astrocytes that may participate in the pathogenesis of HIV-associated dementia...
  64. ncbi The first intron of the human osteopontin gene contains a C/EBP-beta-responsive enhancer
    Francesca Giacopelli
    Laboratory of Molecular Genetics, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Gene Expr 11:95-104. 2003
    ..We found a bi-allelic sequence polymorphism at +245 in the first intron, which did not show a significant functional effect, but is a useful tool for future association studies...
  65. ncbi A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
    Justin Lamb
    Departments of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:323-34. 2003
    ..This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ...
  66. ncbi Dominant-negative effect of the c-fos family gene products on inducible NO synthase expression in macrophages
    Seiji Okada
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int Immunol 15:1275-82. 2003
    ..Thus, overproduction of c-Fos family proteins acts as a dominant-negative-type regulator on iNOS expression in activated macrophages...
  67. ncbi A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas
    Franziska Jundt
    Charite, Campus Virchow Klinikum, University Medicine Berlin, Augustenburger Platz 1, D 13 353 Berlin, Germany
    Blood 106:1801-7. 2005
    ..RAD down-regulated the truncated isoform of the transcription factor CCAAT enhancer binding protein beta (C/EBPbeta), which is known to disrupt terminal differentiation and induce a transformed phenotype...
  68. pmc Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3
    Alok Agrawal
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA
    Immunology 108:539-47. 2003
    ..They raise the possibility, not as yet established, that NF-kappaB activation may be responsible for the synergistic effect of IL-1beta on IL-6-induced CRP expression...
  69. ncbi A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells
    Manja P Holland
    Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, USA
    Endocrinology 145:1096-105. 2004
    ..These studies provide the first insight into the mechanism(s) of Dlx3 gene expression in placental cells and suggest a role for C/EBP beta in the basal regulation of the Dlx3 gene...
  70. pmc A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes
    Kenji Hata
    Department of Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 25:1971-9. 2005
    ..Thus, identification of a novel role of the C/EBPbeta isoform provides insight into the molecular basis of the regulation of osteoblast and adipocyte commitment...
  71. pmc Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages
    Naohiko Tanaka
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, N Y U School of Medicine, New York, NY 10016, USA
    Am J Respir Cell Mol Biol 33:406-11. 2005
    ..Only macrophages are able to repress HIV-1 LTR promoter activity and inhibit viral replication in response to IL-10 or type I IFN...
  72. ncbi Ras induces mediator complex exchange on C/EBP beta
    Xianming Mo
    Max Delbruck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
    Mol Cell 13:241-50. 2004
    ..These results show that a Ras-induced structural alteration of C/EBPbeta determines differential gene activation through selective interaction with distinct Mediator complexes...
  73. pmc Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation
    Joshua R Friedman
    Department of Genetics, Bioinformatics Core, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:12986-91. 2004
    ..This approach is generally applicable to the discovery of direct, biologically relevant targets of mammalian transcription factors...
  74. ncbi Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts
    Weizhong Chang
    Section of Plastic Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 279:42438-44. 2004
    ....
  75. ncbi Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells
    Mark Christian
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 277:20825-32. 2002
    ..These results provide the first evidence of regulated expression of FKHR and demonstrate that FKHR has an integral role in PKA-dependent endometrial differentiation through its ability to bind and functionally cooperate with C/EBPbeta...
  76. ncbi The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 179:5378-86. 2007
    ..Collectively, we demonstrated that 34-kDa LAP is responsible for NF-IL6-mediated gene induction, but not essential for intracellular bacteria killing in activated macrophages...
  77. ncbi Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity
    Alejandro Villagra
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160 C, 4079100 Concepcion, Chile
    J Biol Chem 281:22695-706. 2006
    ..Together, our results indicate that the SWI/SNF complex is a key regulator of the chromatin-remodeling events that promote tissue-specific transcription in osteoblasts...
  78. pmc The interferon signaling network and transcription factor C/EBP-beta
    Hui Li
    Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, 660 W Redwood Street, Baltimore, MD 21201, USA
    Cell Mol Immunol 4:407-18. 2007
    ..Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses...
  79. ncbi The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors
    J Caramel
    Institut Curie, Research Section, Paris, France
    Oncogene 27:2035-44. 2008
    ....
  80. ncbi Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice
    John R Harrison
    Department of Orthodontics, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 280:8117-24. 2005
    ..3-green fluorescent protein, demonstrating a cell-autonomous effect of the transgene. These data suggested that C/EBP transcription factors may be important determinants of osteoblast function and bone mass...
  81. ncbi Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription
    M Niehof
    Department of Gastroenterology and Hepatology, Medizinische Hochschule, Cal-Neuberg-Str. 1, D30625 Hannover, Germany
    J Mol Biol 309:855-68. 2001
    ....
  82. pmc C/EBP beta and Elk-1 synergistically transactivate the c-fos serum response element
    M Hanlon
    Department of Molecular Physiology and Biophysics Vanderbilt University School of Medicine, Nashville, Tennessee USA
    BMC Cell Biol 1:2. 2000
    ..Due to these common observations, we addressed the possibility that C/EBPbeta and Elk-1 could both be necessary for Ras-stimulated transactivation of the SRE...
  83. pmc Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation
    Xi Li
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:11597-602. 2007
    ..Thus, MAPK and cdk2/cyclinA act sequentially to maintain Thr(188) of C/EBPbeta in the primed phosphorylated state during MCE and thereby progression of terminal differentiation...
  84. ncbi CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo
    Annie Paquin
    Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Neurosci 25:10747-58. 2005
    ..Thus, activation of an MEK-C/EBP pathway in cortical precursors in vivo biases them to become neurons and against becoming astrocytes, thereby acting as a growth factor-regulated switch...
  85. ncbi Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microglia
    Aroa Ejarque-Ortiz
    Department of Pharmacology and Toxicology, IIBB CSIC, IDIBAPS, E 08036 Barcelona, Spain
    Glia 55:178-88. 2007
    ..Given the nature of the C/EBPbeta-regulated genes, we hypothesize that this factor participates in neurotoxic effects associated with glial activation. (c) 2006 Wiley-Liss, Inc...
  86. ncbi Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function
    K Yoon
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Oncogene 26:360-7. 2007
    ....
  87. ncbi Differential roles of C/EBP beta regulatory domains in specifying MCP-1 and IL-6 transcription
    Chauncey J Spooner
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 44:1384-92. 2007
    ..LIP, the naturally occurring truncated form of C/EBPbeta, largely retains these regulatory domains and stimulates IL-6 but not MCP-1 transcription...
  88. ncbi Control of uterine cell proliferation and differentiation by C/EBPbeta: functional implications for establishment of early pregnancy
    Milan K Bagchi
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cell Cycle 5:922-5. 2006
    ..It is postulated that C/EBPbeta controls the expression of critical molecules that regulate proliferation and function of epithelial and stromal cells in the female reproductive tract during the establishment of early pregnancy...
  89. ncbi Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbeta
    Thomas Sebastian
    Laboratory of Protein Dynamics and Signaling, NCI Frederick, Frederick, Maryland 21702 1201, USA
    Cell Cycle 5:953-7. 2006
    ..Here we review the evidence for positive and negative cell cycle regulation by C/EBPbeta and discuss possible mechanisms by which this transcription factor could participate in both cellular senescence and oncogenic transformation...
  90. pmc Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells
    A Y Kolyada
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Mol Med 7:329-43. 2001
    ..Both C/EBPbeta and C/EBPdelta participated in DNA-protein complex formation. CONCLUSION: Both NF-kappaB and C/EBP pathways are important for the transcriptional regulation of the human iNOS gene by IL-1beta in PVEC...
  91. pmc G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta
    Ole Pless
    Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
    J Biol Chem 283:26357-63. 2008
    ..Our data identify C/EBPbeta as a direct substrate of G9a-mediated post-translational modification that alters the functional properties of C/EBPbeta during gene regulation...
  92. ncbi C/EBP-beta mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells
    Xingwu Teng
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Res 90:125-7. 2002
    ..The hypoxia-induced promoter activity was abolished by the C/EBP motif mutation. Thus, C/EBP-beta mediates, at least in part, hypoxia-induced iNOS expression in rPSMs...
  93. pmc C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57
    Makoto Hirata
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e4543. 2009
    ..This study investigated the role of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPbeta) in chondrocytes during endochondral ossification...
  94. ncbi Characterization of C/EBPbeta isoforms in normal versus neoplastic mammary epithelial cells
    E M Eaton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Physiol 189:91-105. 2001
    ..Our preliminary data suggest that the prevalent form of C/EBPbeta in cancer cells, C/EBPbeta- 2, can activate genes which push the cell to divide, such as cyclin D1...
  95. pmc Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokines
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Exp Med 195:495-505. 2002
    ..This is associated with loss of an inhibitory CCAAT enhancer binding protein beta (C/EBPbeta) transcription factor and activation of nuclear factor (NF)-kappaB...
  96. pmc CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms
    N A Timchenko
    Huffington Center on Aging, Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nucleic Acids Res 27:4517-25. 1999
    ..Our data demonstrate that CUGBP1 protein is an important component for the regulation of initiation from different AUG codons of C/EBPbeta mRNA...
  97. ncbi Expression and function of CCAAT/enhancer binding proteinbeta (C/EBPbeta) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells
    L R Dearth
    Molecular, Cellular and Developmental Biology Program, Department of Veterinary Biosciences, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 82:357-70. 2001
    ..Ectopic overexpression of C/EBPbeta LIP (LAP:LIP ratio of approximately 1:1) inhibits mammary epithelial cell differentiation (beta-casein expression)...
  98. ncbi Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo
    Toshiyuki Asaki
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Mol Cell Endocrinol 218:119-28. 2004
    ..Unexpectedly, the transcriptional cascade of adipogenesis in vivo described here is distinct from the cascade in vitro previously reported...
  99. pmc Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
    Maria A Jimenez
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 27:743-57. 2007
    ..Altogether, these data place Ebf1 within the known transcriptional cascade of adipogenesis and suggest critical roles for Ebf1 and Ebf2...
  100. ncbi Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway
    Cheng Huang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    Biochem Biophys Res Commun 348:571-8. 2006
    ..These studies suggest that BBR works on multiple molecular targets as an inhibitor of PPARgamma and alpha, and is a potential weight reducing, hypolipidemic, and hypoglycemic drug...
  101. ncbi Modulation of early human preadipocyte differentiation by glucocorticoids
    Julianna J Tomlinson
    Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Endocrinology 147:5284-93. 2006
    ....

Research Grants63

  1. MODULATION OF IFN ACTION VIA NOVEL REGULATORY FACTORS
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  2. Hepatic Steatosis and ER Stress-Inducible Transcription Factor CREBH
    Kezhong Zhang; Fiscal Year: 2013
    ..Understanding the stress-induced molecular mechanisms in hepatic lipid accumulation and its associated pathogenesis is a key prerequisite for the development of new diagnostics and therapeutics targeting NAFLD. ..
  3. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..These studies are relevant to the hepatocyte proliferation and survival characteristic of many physiological and pathological conditions, including hepatocellular injury, liver regeneration and hepatocellular carcinoma. ..
  4. Redox Control of Apoptosis Signaling
    MARGARET BRIEHL; Fiscal Year: 2009
    ..If this idea is correct, new, more effective anti-lymphoma drugs could be developed to counteract these changes. ..
  5. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
    ..This proposed research will study the effects of IL-17 on mediating the alternative translation of the transcription factor C/EBP?, an event that is known to modulate IL- 17-mediated signaling. ..
  6. C/EBP beta Peptides for the Treatment of Hepatic Fibrosis
    Mario Chojkier; Fiscal Year: 2010
    ..Development of effective treatments for liver fibrosis may also facilitate future treatments for lung and kidney fibrosis. ..
  7. Hormone-Regulated Pathways Controlling Implantation and Fertility
    Milan K Bagchi; Fiscal Year: 2012
    ..They should also aid in developing new molecular diagnostic tools for screening endometrial dysfunction and enable targeted therapeutic strategies for the treatment of infertility. ..
  8. Role of C/EBPbeta in mechanical regulation of MSC potential
    Maya Styner; Fiscal Year: 2013
    ....
  9. SGK1 is a Central Regulator of P. gingivalis-Induced Inflammation
    Huizhi Wang; Fiscal Year: 2013
    ....
  10. Gene Expression in Long-term Memory
    Cristina M Alberini; Fiscal Year: 2011
    ....
  11. C/EBP-beta PEPTIDES FOR THE TREATMENT OF LIVER INJURY AND FIBROSIS
    Mario Chojkier; Fiscal Year: 2013
    ..There is no medication for the treatment or prevention of liver fibrosis. Completion of these tasks for the proposed compounds will allow us proceeding with a Phase-2 STTR and clinical development in patients with liver fibrosis. ..
  12. The role of C/EBPbeta-3 in autophagy
    Maria M Abreu; Fiscal Year: 2011
    ....
  13. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    ....
  14. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ....
  15. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  16. Biological role of modifications to C/EBPbeta-1 and -2
    Linda Sealy; Fiscal Year: 2007
    ..These studies will provide important insights into how misregulated C/EBPbeta isoform expression may contribute to the development of metastatic mammary carcinoma. ..
  17. Cellular Mechanisms that Control SIV & Development of Pneumonia
    Janice Clements; Fiscal Year: 2007
    ..tuberculosis, in humans, and Dr. Christopher Karp, an immunologist who has studied HIV and Multiple Sclerosis and is actively involved in therapeutic treatment of MS patients in INFbeta. ..
  18. Molecular Biology: Viral Glial Gene Interaction in Brain
    Kamel Khalili; Fiscal Year: 2009
    ..This program project brings together basic scientists and physicians with expertise in neurovirology, molecular retrovirology, CNS cell biology, and pathology to perform the studies. ..
  19. Antiadipogenic Influence of HIV Protease Inhibitors
    M Lane; Fiscal Year: 2005
    ..The long term objective of the proposed research is to facilitate the design of anti-HIV therapeutics that lack lipoatrophic potential. ..
  20. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..abstract_text> ..
  21. REGULATION OF TRANSTHYRETIN IN THE LIVER
    Pradip Raychaudhuri; Fiscal Year: 2006
    ..abstract_text> ..
  22. A role of acetylation in C/EBPbeta regulation of IL-6
    Richard Schwartz; Fiscal Year: 2004
    ..abstract_text> ..
  23. MECHANISM OF TCDD SUPPRESSION OF ADIPOGENESIS
    Colin Jefcoate; Fiscal Year: 2002
    ..This research will provide insight into general mechanisms through which TCDD alters differentiation, as well as provide a noel approach to the mechanism of adipogenesis and the action of TZD drugs, now a treatment for Type II disease. ..
  24. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ....
  25. ALTERED C/EBPB REGULATION IN IPF LUNG FIBROBLASTS
    Roberto Cruz Gervis; Fiscal Year: 2003
    ..This work could provide a rationale for treatment of IPF with either the p20C/EBPbeta protein or the gene encoding this C/EBPbeta isoform. ..
  26. C/EBP BETA TRANSLATION PRODUCTS IN MAMMARY EPITHELIUM
    Julie Hutt; Fiscal Year: 2002
    ..The Department of Veterinary Biosciences is a highly productive research-oriented professional training environment. ..
  27. C/EBP ALPHA REGULATION OF ACUTE PHASE RESPONSE IN VIVO
    Gretchen Darlington; Fiscal Year: 2004
    ..In aim 4, the biological consequences of the truncated isoforms of C/EBPbeta will be examined in transgenic and cell culture models. ..
  28. EFFECT OF FAT DEPOT ORIGIN ON PREADIPOCYTE FUNCTION
    James Kirkland; Fiscal Year: 2004
    ..These studies will point to potential future strategies for altering function in specific fat depots. ..
  29. Liver Lung Interactions in Lung Inflammation
    Brian Christman; Fiscal Year: 2006
    ..Activation of two transcription factors, nuclear factor kappa B (NFkB) and CCAAT enhancer binding protein beta (C/EBPbeta a.k.a...
  30. P20, 'MOLECULAR SHORTSTOP' FOR INFLAMATORY LUNG DISEASES
    Kenneth Brigham; Fiscal Year: 2000
    ..This concept could provide a new therapeutic approach to a host of inflammatory lung diseases, including idiopathic pulmonary fibrosis, ARDS, cystic fibrosis and asthma. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  31. HORMONAL CONTROL OF ADIPOSE GENE EXPRESSION
    M Lane; Fiscal Year: 2007
    ..The 32kDa CUP/AP-2alpha- interacting protein, p32, previously identified in our lab, will be characterized and its role determined. ..
  32. PROLACTIN IN ADIPOSE TISSUE DEVELOPMENT AND FUNCTION
    Jon Oden; Fiscal Year: 2003
    ..These studies should provide new information regarding the roles of the lactogens in lipid metabolism. ..
  33. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  34. REGULATION OF BCL2 BY RAS AND TUMOR SUPPRESSORS
    ALBERT BALDWIN JR; Fiscal Year: 2001
    ....
  35. p20, Molecular Shortstop for Inflammatory Lung Diseases
    Kenneth Brigham; Fiscal Year: 2003
    ..abstract_text> ..
  36. LIVER-LUNG INTERACTIONS FOLLOWING LIVER INJURY
    LEONARD WUDEL; Fiscal Year: 2002
    ..cytokines involves activation of two transcription factors, nuclear factor kappa B (NF-kappa B) and CCAAT enhancer binding protein beta (C/EBPbeta, also known as NF-IL6) and activation is well-documented in several inflammatory states...
  37. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..abstract_text> ..
  38. ACCESSORY CELL ACTIVATION OF THE IMMUNE RESPONSE
    PHILIP AURON; Fiscal Year: 2004
    ..abstract_text> ..
  39. C/EBP, p300 and atrogin-1 in muscle wasting
    Amy Evenson; Fiscal Year: 2005
    ..The use of cultured muscle cells will allow for defining mechanisms of muscle wasting at the gene level. ..
  40. INVESTIGATION OF AUTOSTIMULATORY PATHWAYS REGULATING HIV
    Andrew Henderson; Fiscal Year: 2003
    ....
  41. Regulation of the Manganous Superoxide Dismutase Gene
    JEREMY BOSS; Fiscal Year: 2005
    ....
  42. IL-1 RECEPTOR MEDIATED SIGNAL TRANSDUCTION
    PHILIP AURON; Fiscal Year: 2003
    ..A new IL-1 mutation extends the earlier data arguing for an interplay between signal transduction pathways and the association of the IL-1 ligand with the receptor. ..
  43. REGULATION OF THE HUMAN INOS GENE IN SEPSIS AND TRAUMA
    David Geller; Fiscal Year: 2007
    ..abstract_text> ..
  44. Role of Opioids and Complements in AIDS Pathogenesis
    Prasun K Datta; Fiscal Year: 2010
    ..The results of these studies will facilitate a better understanding of the mechanisms of complement-mediated injury in HIV infection and drug abuse, and serve as an effective training/mentoring mechanism for the PI. ..
  45. TOOLS FOR DISCOVERY OF ANTI-OSTEOPOROTIC DRUGS
    Bernd Stein; Fiscal Year: 1999
    ..Towards this goal we will screen for compounds that inhibit IL-6 gene expression. We established whole cell screening assays and follow-up assays including a human osteoblast/osteoclast co-culture system. ..
  46. IL-6 in late preconditioning
    Buddhadeb Dawn; Fiscal Year: 2006
    ..This information may eventually lead to the development of novel therapeutic strategies to protect the heart in patients with ischemic heart disease. ..
  47. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  48. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..
  49. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..Based on data obtained in this project, we are planning to start developing a strategy to correct liver proliferation in elderly. ..
  50. TUMOR GROWTH INHIBITION BY INTERFERON B AND RETINOIDS
    DHAN KALVAKOLANU; Fiscal Year: 2001
    ..This proposal is a translational study that provides a basis and the necessary reagents for future phase II trials with IFN/RA or other drug combinations for cancer therapy. ..
  51. TETRAHYDROBIOPTERIN BIOSYNTHESIS BY DOPAMINE NEURONS
    Gregory Kapatos; Fiscal Year: 2008
    ..We expect that this multidisciplinary approach will yield important new information on the role of GCH1 in NSDA neuron function and will lead to a new understanding of DRD and familial and idiopathic PD. ..
  52. Epigallocatechin gallate, Prostate cancer & Angiogenesis
    Myoung Kim; Fiscal Year: 2004
    ..abstract_text> ..
  53. VITAMIN D PLANT ANTIOXIDANT SILIBININ IN LEUKEMIA TRANSLATIONAL STUDY
    George P Studzinski; Fiscal Year: 2010
    ..Thus, myeloid leukemia can be considered an orphan disease, and merits support from public sources for the development of novel therapy. ..
  54. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Functional characterization of the C/EBPB isoforms and the receptor tyrosine kinase pathways that regulate their expression will further our understanding of the molecular basis of mammary development and tumorigenesis. ..
  55. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  56. HEPATIC CARCINOGENESIS: MOLECULAR MECHANISMS
    Martina Buck; Fiscal Year: 2006
    ..abstract_text> ..
  57. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
    ..The suppressive effects of the kinase inhibitors on activation-associated microglial functions; i.e., targeting of oligodendrocytes and myelin phagocytosis will be tested using in vitro models. ..
  58. C/EBP BETA IN HEPATOCYTE GENE EXPRESSION & PROLIFERATION
    Mario Chojkier; Fiscal Year: 2002
    ....
  59. Combinatorial Approaches to Activators of the NGF Recep*
    Nicholas Webster; Fiscal Year: 2005
    ..The Specific Aim of this proposal is to screen the combinatorial asterriquinone library against the NGF receptor. ..
  60. Cell Cycle Regulation and Leukemogenesis by CBFb-SMMHC
    Alan Friedman; Fiscal Year: 2007
    ....
  61. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2007
    ..Also, the newly purchased mass spec will enable on site protein analysis for the studies described above. In short, the environment at TTUHSC is exceptional and will fully support my proposed studies. ..
  62. CONTROL OF OSTEOGENESIS AND ADIPOGENESIS BY EBF
    Mark C Horowitz; Fiscal Year: 2010
    ..Such information would be applicable to a wide variety of skeletal defects including age-related osteopenia, post-menopausal osteoporosis, fracture repair, and extended survival of prosthetic implants. ..
  63. REGULATION OF BONE REMODELING BY MEGAKARYOCYTES
    Mark Horowitz; Fiscal Year: 2009
    ..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..