mads domain proteins

Summary

Summary: A superfamily of proteins that share a highly conserved MADS domain sequence motif. The term MADS refers to the first four members which were MCM1 PROTEIN; AGAMOUS PROTEIN; DEFICIENS PROTEIN; and SERUM RESPONSE FACTOR. Many MADS domain proteins have been found in species from all eukaryotic kingdoms. They play an important role in development, especially in plants where they have an important role in flower development.

Top Publications

  1. ncbi Integration of spatial and temporal information during floral induction in Arabidopsis
    Philip A Wigge
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 309:1056-9. 2005
  2. ncbi FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex
    Mitsutomo Abe
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 309:1052-6. 2005
  3. ncbi Activation tagging of the floral inducer FT
    I Kardailsky
    Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 286:1962-5. 1999
  4. ncbi A pair of related genes with antagonistic roles in mediating flowering signals
    Y Kobayashi
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 286:1960-2. 1999
  5. ncbi The major clades of MADS-box genes and their role in the development and evolution of flowering plants
    Annette Becker
    Lehrstuhl fur Genetik, Friedrich Schiller Universitat Jena, Philosophenweg 12, D 07743 Jena, Germany
    Mol Phylogenet Evol 29:464-89. 2003
  6. ncbi Distinct roles of CONSTANS target genes in reproductive development of Arabidopsis
    A Samach
    John Innes Centre, Norwich NR4 7UH, UK
    Science 288:1613-6. 2000
  7. ncbi MEF2: a central regulator of diverse developmental programs
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Development 134:4131-40. 2007
  8. pmc The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation
    C C Sheldon
    Commonwealth Scientific and Industrial Research Organisation, Division of Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
    Plant Cell 11:445-58. 1999
  9. ncbi Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target
    Szymon Swiezewski
    John Innes Centre, Colney, Norwich, NR4 7UH, UK
    Nature 462:799-802. 2009
  10. ncbi Regulation and identity of florigen: FLOWERING LOCUS T moves center stage
    Franziska Turck
    Max Planck Institute for Plant Breeding, D 50829 Cologne, Germany
    Annu Rev Plant Biol 59:573-94. 2008

Detail Information

Publications272 found, 100 shown here

  1. ncbi Integration of spatial and temporal information during floral induction in Arabidopsis
    Philip A Wigge
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 309:1056-9. 2005
    ..A complex of FT and FD proteins in turn can activate floral identity genes such as APETALA1 (AP1)...
  2. ncbi FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex
    Mitsutomo Abe
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 309:1052-6. 2005
    ..FT may represent a long-distance signal in flowering...
  3. ncbi Activation tagging of the floral inducer FT
    I Kardailsky
    Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 286:1962-5. 1999
    ..Instead, it is similar to the sequence of TERMINAL FLOWER 1 (TFL1), an inhibitor of flowering that also shares sequence similarity with membrane-associated mammalian proteins...
  4. ncbi A pair of related genes with antagonistic roles in mediating flowering signals
    Y Kobayashi
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 286:1960-2. 1999
    ..FT acts in part downstream of CO and mediates signals for flowering in an antagonistic manner with its homologous gene, TERMINAL FLOWER1 (TFL1)...
  5. ncbi The major clades of MADS-box genes and their role in the development and evolution of flowering plants
    Annette Becker
    Lehrstuhl fur Genetik, Friedrich Schiller Universitat Jena, Philosophenweg 12, D 07743 Jena, Germany
    Mol Phylogenet Evol 29:464-89. 2003
    ..We put special emphasis on gene clades for which insights into their importance has rapidly increased just recently...
  6. ncbi Distinct roles of CONSTANS target genes in reproductive development of Arabidopsis
    A Samach
    John Innes Centre, Norwich NR4 7UH, UK
    Science 288:1613-6. 2000
    ..The SOC1 and FT genes are also regulated by a second flowering-time pathway that acts independently of CO. Thus, early target genes of CO define common components of distinct flowering-time pathways...
  7. ncbi MEF2: a central regulator of diverse developmental programs
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Development 134:4131-40. 2007
    ..We review the myriad roles of MEF2 in development and the mechanisms through which it couples developmental, physiological and pathological signals with programs of cell-specific transcription...
  8. pmc The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation
    C C Sheldon
    Commonwealth Scientific and Industrial Research Organisation, Division of Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
    Plant Cell 11:445-58. 1999
    ..FLF maps to a region on chromosome 5 near the FLOWERING LOCUS C gene, which is a semidominant repressor of flowering in late-flowering ecotypes of Arabidopsis...
  9. ncbi Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target
    Szymon Swiezewski
    John Innes Centre, Colney, Norwich, NR4 7UH, UK
    Nature 462:799-802. 2009
    ..Antisense transcription events originating from 3' ends of genes might be a general mechanism to regulate the corresponding sense transcription in a condition/stage-dependent manner...
  10. ncbi Regulation and identity of florigen: FLOWERING LOCUS T moves center stage
    Franziska Turck
    Max Planck Institute for Plant Breeding, D 50829 Cologne, Germany
    Annu Rev Plant Biol 59:573-94. 2008
    ..Finally, we discuss conservation of FT function in other species and how variation in its regulation could generate different flowering behaviors...
  11. ncbi A thermosensory pathway controlling flowering time in Arabidopsis thaliana
    Miguel A Blázquez
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 33:168-71. 2003
    ..As with vernalization and photoperiod, ambient temperature ultimately affects expression of the floral pathway integrator FT...
  12. pmc The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis
    Iain Searle
    Max Planck Institute for Plant Breeding, D 50829 Cologne, Germany
    Genes Dev 20:898-912. 2006
    ..Thus vernalization relieves transcriptional repression of key regulatory genes in both the leaf and meristem, allowing production of systemic signals in the leaves and conferring competence on the meristem to respond to these signals...
  13. pmc MADS-box gene family in rice: genome-wide identification, organization and expression profiling during reproductive development and stress
    Rita Arora
    Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi, India
    BMC Genomics 8:242. 2007
    ....
  14. ncbi Vernalization requires epigenetic silencing of FLC by histone methylation
    Ruth Bastow
    Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Nature 427:164-7. 2004
    ..The epigenetic memory of winter is thus mediated by a 'histone code' that specifies a silent chromatin state conserved between animals and plants...
  15. pmc Loss of FLOWERING LOCUS C activity eliminates the late-flowering phenotype of FRIGIDA and autonomous pathway mutations but not responsiveness to vernalization
    S D Michaels
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706-1544, USA
    Plant Cell 13:935-41. 2001
    ..Thus, FRI and the autonomous pathway may act solely to regulate FLC expression, whereas vernalization is able to promote flowering via FLC-dependent and FLC-independent mechanisms...
  16. ncbi A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus
    Julia Vrebalov
    U S Department of Agriculture Agricultural Research Service USDA ARS Plant, Soil and Nutrition Lab and Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Science 296:343-6. 2002
    ..LeMADS-RIN demonstrates an agriculturally important function of plant MADS-box genes and provides molecular insight into nonhormonal (developmental) regulation of ripening...
  17. pmc Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world
    Lucie Parenicová
    Dipartimento di Biologia, Universitá degli Studi di Milano, 20133 Milan, Italy
    Plant Cell 15:1538-51. 2003
    ..MADS-box genes also constitute an excellent system with which to study the evolution of complex gene families in higher plants...
  18. pmc Ectopic expression of the petunia MADS box gene UNSHAVEN accelerates flowering and confers leaf-like characteristics to floral organs in a dominant-negative manner
    Silvia Ferrario
    Business Unit Bioscience, Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 16:1490-505. 2004
    ....
  19. ncbi AGAMOUS-LIKE24 and SHORT VEGETATIVE PHASE determine floral meristem identity in Arabidopsis
    Veronica Gregis
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Plant J 56:891-902. 2008
    ..Furthermore, our results explain how AP1 switches from a floral meristem identity factor to a component that controls floral organ identity...
  20. pmc Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb repressive complex 2 components
    Danhua Jiang
    Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore
    PLoS ONE 3:e3404. 2008
    ..Given the central roles of FLC and FT in flowering-time regulation in Arabidopsis, these findings suggest that the CLF-containing PRC2-like complexes play a significant role in control of flowering in Arabidopsis...
  21. pmc Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1
    Julia Vrebalov
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 21:3041-62. 2009
    ..From this broad perspective, SHP1/2 and TAGL1, while distinct in molecular function, regulate similar activities via their necessity for seed dispersal in Arabidopsis and tomato, respectively...
  22. ncbi A repressor complex governs the integration of flowering signals in Arabidopsis
    Dan Li
    Department of Biological Sciences and Temasek Life Sciences Laboratory, National University of Singapore, 10 Science Drive 4, 117543, Singapore
    Dev Cell 15:110-20. 2008
    ..Our findings suggest that SVP is another central regulator of the flowering regulatory network, and that the interaction between SVP and FLC mediated by various flowering genetic pathways governs the integration of flowering signals...
  23. ncbi The 'ABC' of MADS domain protein behaviour and interactions
    Richard G H Immink
    Plant Research International, Bioscience, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
    Semin Cell Dev Biol 21:87-93. 2010
    ..made in our understanding of the molecular mechanisms underlying the combinatorial activity of the encoded MADS domain proteins. Here, we review how various state-of-the-art technologies were implemented in order to unravel the protein-..
  24. ncbi Targeted 3' processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing
    Fuquan Liu
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 327:94-7. 2010
    ..Targeted 3' processing of antisense transcripts may be a common mechanism triggering transcriptional silencing of the corresponding sense gene...
  25. ncbi The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC
    Fuquan Liu
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Mol Cell 28:398-407. 2007
    ..These data support a close association of FCA and FLD in mediating H3K4 demethylation and thus transcriptional silencing of FLC and reveal roles for antisense RNA processing and DCL3 function in this regulation...
  26. pmc HDAC4 deacetylase associates with and represses the MEF2 transcription factor
    E A Miska
    Wellcome CRC Institute, Department of Pathology, Cambridge, UK
    EMBO J 18:5099-107. 1999
    ..These results identify MEF2A as a nuclear target for HDAC4-mediated repression and suggests that compartmentalization may be a novel mechanism for controlling the nuclear activity of this new family of deacetylases...
  27. pmc EMF genes maintain vegetative development by repressing the flower program in Arabidopsis
    Yong Hwan Moon
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 15:681-93. 2003
    ..Based on these findings, a new mechanism of EMF-mediated floral repression is proposed...
  28. pmc Multiple pathways in the decision to flower: enabling, promoting, and resetting
    Paul K Boss
    Department of Cell and Developmental Biology, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 16:S18-31. 2004
  29. pmc Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait
    Ana L Caicedo
    Genetics Department, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 101:15670-5. 2004
    ....
  30. ncbi Flowering-time genes modulate meristem determinacy and growth form in Arabidopsis thaliana
    Siegbert Melzer
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, Ghent, Belgium
    Nat Genet 40:1489-92. 2008
    ..In addition, downregulation of both proteins established phenotypes common to the lifestyle of perennial plants, suggesting their involvement in the prevention of secondary growth and longevity in annual life forms...
  31. ncbi The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high-molecular-weight protein complex
    Chris A Helliwell
    CSIRO Plant Industry, GPO Box 1600, Canberra ACT 2601, Australia
    Plant J 46:183-92. 2006
    ..We have shown that FLC is a component of a multimeric protein complex in vivo and that more than one FLC polypeptides can be present in the complex...
  32. ncbi SOC1 translocated to the nucleus by interaction with AGL24 directly regulates leafy
    Jungeun Lee
    Department of Biological Sciences, National Research Laboratory of Plant Developmental Genetics, Seoul National University, Seoul, Korea
    Plant J 55:832-43. 2008
    ..Finally, we show that LFY is expressed only in those tissues where SOC1 and AGL24 expressions overlap. Thus, we propose that heterodimerization of SOC1 and AGL24 is a key mechanism in activating LFY expression...
  33. ncbi The Arabidopsis thaliana MEDEA Polycomb group protein controls expression of PHERES1 by parental imprinting
    Claudia Kohler
    Institute of Plant Biology and Zurich Basel Plant Science Center, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Nat Genet 37:28-30. 2005
    ..Because Polycomb group proteins control parental imprinting in mammals as well, the independent recruitment of similar protein machineries for the imprinting of genes is a notable example of convergent evolution...
  34. pmc The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC)
    C C Sheldon
    Commonwealth Scientific and Industrial Research Organization, Division of Plant Industry, G P O Box 1600, Canberra, ACT 2600, Australia
    Proc Natl Acad Sci U S A 97:3753-8. 2000
    ..Other vernalization-responsive late-flowering mutants, which are disrupted in genes that encode regulators of FLC, are late-flowering as a consequence of their elevated levels of FLC...
  35. pmc Target genes of the MADS transcription factor SEPALLATA3: integration of developmental and hormonal pathways in the Arabidopsis flower
    Kerstin Kaufmann
    Business Unit Bioscience, Plant Research International, Wageningen, The Netherlands
    PLoS Biol 7:e1000090. 2009
    ....
  36. ncbi Functional analyses of the flowering time gene OsMADS50, the putative SUPPRESSOR OF OVEREXPRESSION OF CO 1/AGAMOUS-LIKE 20 (SOC1/AGL20) ortholog in rice
    Shinyoung Lee
    National Research Laboratory of Plant Functional Genomics, Division of Molecular and Life Sciences, Pohang University of Science and Technology POSTECH, Pohang 790 784, Korea
    Plant J 38:754-64. 2004
    ..sativa GIGANTEA (OsGI). These results suggest that OsMADS50 is an important flowering activator that controls various floral regulators in rice...
  37. ncbi The SOC1 MADS-box gene integrates vernalization and gibberellin signals for flowering in Arabidopsis
    Jihyun Moon
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Plant J 35:613-23. 2003
    ..Our results explain why the GA pathway has a strong effect on flowering under short days and how vernalization and GA interact at the molecular level...
  38. pmc Crosstalk between cold response and flowering in Arabidopsis is mediated through the flowering-time gene SOC1 and its upstream negative regulator FLC
    Eunjoo Seo
    National Research Laboratory of Plant Developmental Genetics, School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Plant Cell 21:3185-97. 2009
    ....
  39. pmc An AGAMOUS-related MADS-box gene, XAL1 (AGL12), regulates root meristem cell proliferation and flowering transition in Arabidopsis
    Rosalinda Tapia-López
    Laboratorio de Genetica Molecular, Desarrollo y Evolución de Plantas, Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico DF, Mexico
    Plant Physiol 146:1182-92. 2008
    ..We propose that XAL1 may have similar roles in both root and aerial meristems that could explain the xal1 late-flowering phenotype...
  40. pmc MADS box genes control vernalization-induced flowering in cereals
    Ben Trevaskis
    Commonwealth Scientific and Industrial Research Organisation, Division of Plant Industry, G P O Box 1600, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 100:13099-104. 2003
    ..There is now evidence that AP1-like genes determine the time of flowering in a range of cereal and grass species...
  41. pmc MIKC* MADS domain heterodimers are required for pollen maturation and tube growth in Arabidopsis
    Benjamin J Adamczyk
    Department of Botany, University of Wisconsin, Madison, Wisconsin 53706 1381, USA
    Plant Physiol 149:1713-23. 2009
    ..These results were combined to create a model to describe MIKC* heterodimer contributions in pollen...
  42. ncbi A novel MADS-box gene subfamily with a sister-group relationship to class B floral homeotic genes
    A Becker
    Department of Molecular Plant Genetics, Max Planck Institute for Breeding Research, Koln, Germany
    Mol Genet Genomics 266:942-50. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00438-001-0615-8...
  43. pmc Splicing variation at a FLOWERING LOCUS C homeolog is associated with flowering time variation in the tetraploid Capsella bursa-pastoris
    Tanja Slotte
    Department of Evolution, Genomics and Systematics, Uppsala University, SE 752 36 Uppsala, Sweden
    Genetics 183:337-45. 2009
    ..Our results are consistent with the function of FLC as a major repressor of flowering in Arabidopsis thaliana and imply that nonfunctionalization of duplicate genes could provide an important source of phenotypic variation...
  44. ncbi Direct interaction of AGL24 and SOC1 integrates flowering signals in Arabidopsis
    Chang Liu
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore
    Development 135:1481-91. 2008
    ..These observations suggest that during floral transition, a positive-feedback loop conferred by direct transcriptional regulation between AGL24 and SOC1 at the shoot apex integrates flowering signals...
  45. pmc Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis
    Chikako Shindo
    Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Plant Physiol 138:1163-73. 2005
    ..These data reveal how useful these Arabidopsis accessions will be in dissecting the complex molecular variation that has led to the adaptive phenotypic variation in flowering time...
  46. ncbi Repression of the floral transition via histone H2B monoubiquitination
    Xiaofeng Gu
    Department of Biological Sciences, National University of Singapore, Singapore
    Plant J 57:522-33. 2009
    ..These findings are consistent with a model in which HUB1 and HUB2 specifically interact with and direct UBC1 and UBC2 to monoubiquitinate H2B in developmental genes, and thus regulate developmental processes in plants...
  47. ncbi Specification of Arabidopsis floral meristem identity by repression of flowering time genes
    Chang Liu
    Department of Biological Sciences and Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117543, Singapore
    Development 134:1901-10. 2007
    ....
  48. pmc A single amino acid change in the enhancer of zeste ortholog CURLY LEAF results in vernalization-independent, rapid flowering in Arabidopsis
    Mark R Doyle
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Plant Physiol 151:1688-97. 2009
    ..Furthermore, FRI appears to affect CLF occupancy at FLC; thus, our work provides insight into the molecular role that FRI plays in delaying the onset of flowering...
  49. pmc Genome-wide analysis of MIKCC-type MADS box genes in grapevine
    José Díaz-Riquelme
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    Plant Physiol 149:354-69. 2009
    ....
  50. pmc CONSTANS activates SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 through FLOWERING LOCUS T to promote flowering in Arabidopsis
    Seung Kwan Yoo
    Plant Signaling Network Research Center, School of Life Sciences and Biotechnology, Korea University, Seoul
    Plant Physiol 139:770-8. 2005
    ..Taken together, these data suggest that CO activates SOC1 through FT to promote flowering in Arabidopsis...
  51. pmc FLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis
    Weiwei Deng
    Commonwealth Scientific and Industrial Research Organisation Plant Industry, Canberra ACT 2600, Australia
    Proc Natl Acad Sci U S A 108:6680-5. 2011
    ....
  52. pmc The FRIGIDA complex activates transcription of FLC, a strong flowering repressor in Arabidopsis, by recruiting chromatin modification factors
    Kyuha Choi
    National Research Laboratory of Plant Developmental Genetics, School of Biological Sciences, Seoul National University, Seoul, 151 742, Korea
    Plant Cell 23:289-303. 2011
    ..Our results provide insight into how a specific transcription activator recruits chromatin modifiers to regulate a key flowering gene...
  53. pmc AGL80 is required for central cell and endosperm development in Arabidopsis
    Michael F Portereiko
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    Plant Cell 18:1862-72. 2006
    ..Together, these data suggest that FEM111/AGL80 functions as a transcription factor within the central cell gene regulatory network and controls the expression of downstream genes required for central cell development and function...
  54. ncbi HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
    Keqiang Wu
    Institute of Plant Biology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
    J Exp Bot 59:225-34. 2008
    ..Our results suggest that HDA6 is involved in jasmonate response, senescence, and flowering in Arabidopsis...
  55. pmc An ancestral MADS-box gene duplication occurred before the divergence of plants and animals
    E R Alvarez-Buylla
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Proc Natl Acad Sci U S A 97:5328-33. 2000
    ..These analyses may guide the search for MADS-box sequences in basal eukaryotes and the phylogenetic placement of new genes from other plant species...
  56. ncbi A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana
    Hyoun Joung Kim
    Kumho Life and Environmental Science Laboratory, 1 Oryong dong, Puk Gu, Gwangju 500 712, Korea
    Nat Genet 36:167-71. 2004
    ..Dual roles of FVE in regulating the flowering time and the cold response may have an evolutionary advantage for plants by increasing their survival rates...
  57. pmc Characterization of the possible roles for B class MADS box genes in regulation of perianth formation in orchid
    Yu Yun Chang
    Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan 40227, Republic of China
    Plant Physiol 152:837-53. 2010
    ..Further analysis indicated that only ectopic expression of OMADS8 but not OMADS5/9 caused the conversion of the sepal into an expanded petal-like structure in transgenic Arabidopsis (Arabidopsis thaliana) plants...
  58. pmc Different regulatory regions are required for the vernalization-induced repression of FLOWERING LOCUS C and for the epigenetic maintenance of repression
    Candice C Sheldon
    Commonwealth Scientific and Industrial Research Organization, Plant Industry, Canberra, Australian Capital Territory 2601, Australia
    Plant Cell 14:2527-37. 2002
    ..Both promoter and intragenic regions are required for the responses. We also identify a 75-bp region in the FLC promoter that, in addition to intragenic sequences, is required for expression in nonvernalized plants...
  59. pmc Functional characterization of OsMADS18, a member of the AP1/SQUA subfamily of MADS box genes
    Fabio Fornara
    Dipartimento di Biologia, Universita degli Studi di Milano, 20133 Milan, Italy
    Plant Physiol 135:2207-19. 2004
    ..Thus, when compared to AP1, OsMADS18 during evolution seems to have conserved the mechanistic properties of protein-protein interactions, although it cannot complement the AP1 function...
  60. ncbi JOINTLESS is a MADS-box gene controlling tomato flower abscission zone development
    L Mao
    Clemson University Genomics Institute, South Carolina 29634, USA
    Nature 406:910-3. 2000
    ..We propose that a deletion in JOINTLESS accounts for the failure of activation of pedicel AZ development in jointless tomato plants...
  61. ncbi Functional conservation and diversification of class E floral homeotic genes in rice (Oryza sativa)
    Rongfeng Cui
    Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant J 61:767-81. 2010
    ..Moreover, our findings corroborate the view that the lodicules of grasses are homologous to eudicot petals...
  62. ncbi Functional conservation of MADS-box factors controlling floral organ identity in rice and Arabidopsis
    Martin M Kater
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, I 20133 Milano, Italy
    J Exp Bot 57:3433-44. 2006
    ..Therefore it is the right moment to perform a comparative analysis on MADS-box factors controlling floral organ identity as reported in this review...
  63. pmc OsMADS51 is a short-day flowering promoter that functions upstream of Ehd1, OsMADS14, and Hd3a
    Song Lim Kim
    Division of Molecular and Life Sciences and Biotechnology Research Center, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    Plant Physiol 145:1484-94. 2007
    ..These results demonstrate that OsMADS51 functions downstream of OsGI. In summary, OsMADS51 is a novel flowering promoter that transmits a SD promotion signal from OsGI to Ehd1...
  64. pmc FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions
    Jonathan D Werner
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 170:1197-207. 2005
    ..Finally, eXtreme array mapping identified genomic regions linked to the vernalization-independent, late-flowering habit of Bur-0, which has an alternatively spliced FLC allele that behaves as a null allele...
  65. pmc Major-effect alleles at relatively few loci underlie distinct vernalization and flowering variation in Arabidopsis accessions
    Amy Strange
    Department of Cell and Developmental Biology, John Innes Centre, Norwich, England, United Kingdom
    PLoS ONE 6:e19949. 2011
    ..Overall, our data suggest that distinct phenotypic variation in the vernalization and flowering response of Arabidopsis accessions is accounted for by variation that has arisen independently at relatively few major-effect loci...
  66. pmc The flowering integrator FT regulates SEPALLATA3 and FRUITFULL accumulation in Arabidopsis leaves
    Paula Teper-Bamnolker
    Robert H Smith Institute for Plant Sciences and Genetics in Agriculture, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant Cell 17:2661-75. 2005
    ..Organ fate may depend on both degree of activation and the developmental stage reached by the organ before activation occurs...
  67. ncbi Molecular and genetic analyses of the silky1 gene reveal conservation in floral organ specification between eudicots and monocots
    B A Ambrose
    Department of Biology, University of California, San Diego, La Jolla 92093 0116, USA
    Mol Cell 5:569-79. 2000
    ..In addition, they provide compelling developmental evidence for recognizing lodicules as modified petals and, possibly, palea and lemma as modified sepals...
  68. pmc Structural diversification and neo-functionalization during floral MADS-box gene evolution by C-terminal frameshift mutations
    Michiel Vandenbussche
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Nucleic Acids Res 31:4401-9. 2003
    ..3' terminal frameshift mutations might provide an important but so far unrecognized mechanism to generate novel functional C-terminal motifs instrumental to the functional diversification of transcription factor families...
  69. pmc ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C
    Yosuke Tamada
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Plant Cell 21:3257-69. 2009
    ..We show that the flowering phenotype of atx1 atxr7 double mutants is additive relative to those of single mutants. Therefore, both classes of H3K4 methylases appear to be required for proper regulation of FLC expression...
  70. ncbi Regulation of floral patterning by flowering time genes
    Chang Liu
    Department of Biological Sciences and Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    Dev Cell 16:711-22. 2009
    ....
  71. pmc A PHD-polycomb repressive complex 2 triggers the epigenetic silencing of FLC during vernalization
    Filomena De Lucia
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 105:16831-6. 2008
    ....
  72. ncbi The VERNALIZATION 2 gene mediates the epigenetic regulation of vernalization in Arabidopsis
    A R Gendall
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, NR4 7UH, Norwich, United Kingdom
    Cell 107:525-35. 2001
    ..VRN2 function therefore stably maintains FLC repression after a cold treatment, serving as a mechanism for the cellular memory of vernalization...
  73. ncbi The MADS box genes SEEDSTICK and ARABIDOPSIS Bsister play a maternal role in fertilization and seed development
    Chiara Mizzotti
    Dipartimento di Biologia, Universita degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
    Plant J 70:409-20. 2012
    ..The phenotype of the abs stk double mutant highlights the importance of the maternal-derived tissues, particularly the endothelium, for the development of the next generation...
  74. ncbi How MIKC* MADS-box genes originated and evidence for their conserved function throughout the evolution of vascular plant gametophytes
    Michiel Kwantes
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Mol Biol Evol 29:293-302. 2012
    ....
  75. pmc MADS domain transcription factors mediate short-range DNA looping that is essential for target gene expression in Arabidopsis
    Marta Adelina Mendes
    Dipartimento di Bioscienze, Universita degli Studi di Milano, 20133 Milan, Italy
    Plant Cell 25:2560-72. 2013
    ..and protein-protein interaction studies, a floral quartet model was proposed that describes how these MADS domain proteins assemble into higher order complexes to regulate their target genes...
  76. ncbi Characterization and expression of 42 MADS-box genes in wheat (Triticum aestivum L.)
    Tao Zhao
    Department of Plant Genetics and Breeding, State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
    Mol Genet Genomics 276:334-50. 2006
    ..We concluded that multiple MADS-box genes exist in wheat genome and are expressed in tissue-specific patterns, and might play important roles in wheat growth and development...
  77. pmc The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes
    Patrick Achard
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UJ, UK
    Proc Natl Acad Sci U S A 104:6484-9. 2007
    ..Our findings establish a link between the CTR1/EIN3-dependent ethylene and GA-DELLA signaling pathways that enables adaptively significant regulation of plant life cycle progression in response to environmental adversity...
  78. ncbi C- and D-class MADS-box genes from Phalaenopsis equestris (Orchidaceae) display functions in gynostemium and ovule development
    You Yi Chen
    Institute of Tropical Plant Sciences, National Cheng Kung University, Tainan 701, Taiwan
    Plant Cell Physiol 53:1053-67. 2012
    ..Together, these results indicated that both C-class PeMADS1 and D-class PeMADS7 play important roles in orchid gynostemium and ovule development...
  79. pmc The dynamics of soybean leaf and shoot apical meristem transcriptome undergoing floral initiation process
    Chui E Wong
    Plant Molecular Biology and Biotechnology Group, ARC Centre of Excellence for Integrative Legume Research, Melbourne School of Land and Environment, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e65319. 2013
    ..Further, evidence is emerging that the conversion of shoot apical meristem to inflorescence meristem is linked with the interplay of auxin, cytokinin and GA creating a low cytokinin and high GA environment...
  80. ncbi The autonomous pathway: epigenetic and post-transcriptional gene regulation in the control of Arabidopsis flowering time
    Gordon G Simpson
    Gene Expression Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Curr Opin Plant Biol 7:570-4. 2004
    ..Therefore, the broadest lessons we learn from dissecting the function of the autonomous pathway may be in revealing how precision in regulated gene expression is delivered...
  81. pmc MACROCALYX and JOINTLESS interact in the transcriptional regulation of tomato fruit abscission zone development
    Toshitsugu Nakano
    National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki 305 8642, Japan
    Plant Physiol 158:439-50. 2012
    ..The tomato homologs were specifically expressed in AZs but not in other pedicel tissues, suggesting that these transcription factors may play key roles in pedicel AZ development...
  82. pmc Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development
    Cezary Smaczniak
    Laboratory of Molecular Biology, Wageningen University, 6708PB Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 109:1560-5. 2012
    ..Furthermore, members of other transcription factor families were identified as interaction partners of floral MADS-domain proteins suggesting various specific combinatorial modes of action...
  83. ncbi Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies
    Cezary Smaczniak
    Laboratory of Molecular Biology, Wageningen University, 6708PB Wageningen, The Netherlands
    Development 139:3081-98. 2012
    ..We also discuss possible mechanisms of action of MADS-domain proteins based on their interactions with chromatin-associated factors and other transcriptional regulators...
  84. ncbi The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development
    Q Gu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Development 125:1509-17. 1998
    ..These data suggest that AGL8/FUL regulates the transcription of genes required for cellular differentiation during fruit and leaf development...
  85. ncbi INCOMPOSITA: a MADS-box gene controlling prophyll development and floral meristem identity in Antirrhinum
    Simona Masiero
    Abteilung für Molekulare Pflanzengenetik, Max Planck Institut fur Zuchtungsforschung, 50829 Köln, Germany
    Development 131:5981-90. 2004
    ..The complex regulatory and combinatorial relations between INCO, FLORICAULA and SQUAMOSA are summarised in a model that integrates observations from molecular studies as well as analyses of expression patterns and genetic interactions...
  86. pmc The MADS-domain protein MPF1 of Physalis floridana controls plant architecture, seed development and flowering time
    Chaoying He
    State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Xiangshan, Nanxincun 20, 100093 Beijing, China
    Planta 231:767-77. 2010
    ..Taken together, this suggests that members of the STMADS11 subclade act as positive regulators of flowering but have diverse functions in plant growth...
  87. ncbi The Arabidopsis B-sister MADS-box protein, GORDITA, represses fruit growth and contributes to integument development
    Kalika Prasad
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Plant J 62:203-14. 2010
    ..Together, our studies provide evidence of a new regulatory role for a B-sister MADS-box gene in the control of organ growth...
  88. pmc Transcription factor MEF2A mutations in patients with coronary artery disease
    M R Krishna Bhagavatula
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 13:3181-8. 2004
    ..93%) may carry mutations in MEF2A, although further definition of the prevalence of MEF2A mutations is warranted...
  89. pmc Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment
    Yongqing Wu
    Division of Molecular and Computational Biology, Departments of Biological Sciences and Chemistry, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, RRI 204c, 1050 Childs Way, Los Angeles, CA 90089, USA
    J Mol Biol 397:520-33. 2010
    ..The apo structure presented here can also serve as a target for virtual screening and soaking studies of small molecules that can modulate the function of MEF2 as research tools and therapeutic leads...
  90. pmc Regulation of flowering time in Arabidopsis by K homology domain proteins
    Todd C Mockler
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:12759-64. 2004
    ..In addition to FLK, the expression of two other KH domain genes are modestly affected by the flk mutation, suggesting a possible involvement of more than one KH domain protein in the regulation of flowering time in Arabidopsis...
  91. pmc Miscues on the "lack of MEF2A mutations" in coronary artery disease
    Qing Wang
    J Clin Invest 115:1399-400; author reply 1400-1. 2005
  92. ncbi Four DEF-like MADS box genes displayed distinct floral morphogenetic roles in Phalaenopsis orchid
    Wen Chieh Tsai
    Department of Biology, National Cheng Kung University, Tainan 701, Taiwan
    Plant Cell Physiol 45:831-44. 2004
    ..Collectively, this is the first report that four DEF-like MADS genes were identified in a single monocotyledonous species and that they may play distinctive morphogenetic roles in the floral development of an orchid...
  93. pmc MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex
    D Leifer
    Department of Neurology, Children s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 90:1546-50. 1993
    ..The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture...
  94. pmc Arabidopsis cold shock domain proteins: relationships to floral and silique development
    Kentaro Nakaminami
    Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV 26506 6108, USA
    J Exp Bot 60:1047-62. 2009
    ..Collectively, these data support the hypothesis that AtCSPs are involved in the transition to flowering and silique development in Arabidopsis...
  95. ncbi Vascular endothelial growth factor induces MEF2C and MEF2-dependent activity in endothelial cells
    Debasish Maiti
    Department of Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Invest Ophthalmol Vis Sci 49:3640-8. 2008
    ..The purpose of this study was to investigate the regulation of MEF2C expression and MEF2-dependent activity in endothelial cells by VEGF...
  96. ncbi Transcription-dependence of histone H3 lysine 27 trimethylation at the Arabidopsis polycomb target gene FLC
    Diana Mihaela Buzas
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    Plant J 65:872-81. 2011
    ..Our data suggest that reduction of FLC transcription during vernalization leads to an increase of H3K27me3 levels in the FLC gene body that in turn maintains FLC repression...
  97. ncbi Polycomb proteins regulate the quantitative induction of VERNALIZATION INSENSITIVE 3 in response to low temperatures
    E Jean Finnegan
    CSIRO, Climate Adaptation Flagship, Canberra, ACT 2601, Australia
    Plant J 65:382-91. 2011
    ..The observation that Polycomb proteins control VIN3 activity defines a new role for Polycomb proteins in regulating the rate of gene induction...
  98. pmc Interactions among APETALA1, LEAFY, and TERMINAL FLOWER1 specify meristem fate
    S J Liljegren
    Department of Biology and Center for Molecular Genetics, University of California at San Diego, La Jolla, California 92093, USA
    Plant Cell 11:1007-18. 1999
    ....
  99. pmc Parental genome dosage imbalance deregulates imprinting in Arabidopsis
    Pauline E Jullien
    Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    PLoS Genet 6:e1000885. 2010
    ..The complexity of the network of regulations between expressed and silenced alleles of imprinted genes activated in response to parental dosage imbalance does not support simple models derived from the parental conflict hypothesis...
  100. pmc KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC
    Alexander M van der Linden
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    EMBO J 26:358-70. 2007
    ..elegans...
  101. ncbi The Arabidopsis defense component EDM2 affects the floral transition in an FLC-dependent manner
    Tokuji Tsuchiya
    Center for Plant Cell Biology, Institute for Integrative Genome Biology, Department of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, USA
    Plant J 62:518-28. 2010
    ....

Research Grants12

  1. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..
  2. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  3. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  4. Laser Microdissection System
    Eric Olson; Fiscal Year: 2004
    ....
  5. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..End of Abstract) ..
  6. Control of Cardiac Gene Expression Through Regulated Transcriptional Coactivators
    Eric N Olson; Fiscal Year: 2010
    ..abstract_text> ..
  7. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Molecular Mechanisms of Anthrax-Induced Macrophage Death
    Jiahuai Han; Fiscal Year: 2007
    ..The information obtained in this study will be very valuable in developing new strategies for the treatment of anthrax infection. [unreadable] [unreadable]..
  9. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2006
    ..Our study will also lead to a better understanding of how macrophage apoptosis is controlled, which is needed to develop therapeutically useful strategies to selectively promote or inhibit macrophage death. ..
  10. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  11. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard M Amasino; Fiscal Year: 2010
    ..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
  12. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..