oncogene proteins v myb

Summary

Summary: Transforming proteins coded by myb oncogenes. Transformation of cells by v-myb in conjunction with v-ets is seen in the avian E26 leukemia virus.

Top Publications

  1. pmc The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication
    Holger Gundelach
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str, 2, D 48149 Munster, Germany
    BMC Mol Biol 8:75. 2007
  2. ncbi Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter
    Tahir H Tahirov
    Kanagawa Academy of Science and Technology, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell 108:57-70. 2002
  3. ncbi The chicken Pdcd4 gene is regulated by v-Myb
    U Schlichter
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Oncogene 20:231-9. 2001
  4. ncbi The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
    S A Ness
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 59:1115-25. 1989
  5. pmc Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M
    M Oelgeschlager
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    EMBO J 15:2771-80. 1996
  6. pmc Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    EMBO J 12:2027-38. 1993
  7. ncbi Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene
    M Introna
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 63:1289-97. 1990
  8. pmc Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain
    Xianming Mo
    Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 19:2447-57. 2005
  9. pmc v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter
    Olesya Chayka
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Strasse 2, D 48149 Munster, Germany
    Mol Cell Biol 25:499-511. 2005
  10. ncbi The chicken adenosine receptor 2B gene is regulated by v-myb
    S Worpenberg
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Oncogene 15:213-21. 1997

Research Grants

  1. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003

Scientific Experts

  • J Stokrova
  • Karl Heinz Klempnauer
  • Paul J Sheridan
  • Shu Ling Fu
  • Holger Gundelach
  • Thomas J Gonda
  • Kais Hussein
  • Emily Ray Ko
  • S A Ness
  • K Noben-Trauth
  • D Rhodes
  • L Wolff
  • R Bernards
  • Benoit Pinson
  • Jan Smarda
  • Joseph Lipsick
  • Daniel Braas
  • Olesya Chayka
  • J S Lipsick
  • V Karafiat
  • Olga Ivanova
  • Vichanan Yamkamon
  • Jarmila Navrátilová
  • Petr Benes
  • Jörg Kintscher
  • M Dvorak
  • D M Wang
  • Jana Smardova
  • Alice Nemajerova
  • Raffaella Petruzzelli
  • O Burk
  • Tim C P Somervaille
  • Hong Ming Hsu
  • M Dvorakova
  • P Pajer
  • Annette Plachetka
  • Iva Mozgová
  • L Knopfova
  • Silke Tillmanns
  • Cristina B B Lira
  • Eva Ondrousková
  • Zbynek Zdrahal
  • Hana Konecná
  • F Liu
  • S Worpenberg
  • Xianming Mo
  • S Sevcikova
  • E M Brendeford
  • Chie Kanei-Ishii
  • Pierre Jurdic
  • V Cermak
  • Michael Korenjak
  • Anthony D Kang
  • Jarmila Kralova
  • E Zahradnícková
  • Kuniyoshi Iwabuchi
  • Shunsuke Ishii
  • Emi Ichikawa-Iwata
  • Paul A Bartley
  • Shoucai Chen
  • Tatjana S Polony
  • Xianfang Meng
  • Michal Dvorak
  • Duen Mei Wang
  • Petr Bartunek
  • Tahir H Tahirov
  • Dana Kattmann
  • Silvia Monticelli
  • T H Tahirov
  • U Schlichter
  • Raffaele Sessa
  • Sara Gaudino
  • Giovanna d'Urzo
  • Stella Puzone
  • Paola Izzo
  • Michela Grosso
  • J Kralova
  • Giovanni Amendola
  • Rosanna Di Concilio
  • Maria Amendolara
  • Michael L Cleary
  • James R Downing
  • Gary J Spencer
  • Shiou Jeng Ong
  • Masayuki Iwasaki
  • Daniela M Witten
  • Howard Y Chang
  • John L Rinn
  • Ming Chun Lee
  • Jung Hsiang Tai

Detail Information

Publications103 found, 100 shown here

  1. pmc The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication
    Holger Gundelach
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str, 2, D 48149 Munster, Germany
    BMC Mol Biol 8:75. 2007
    ..Because of this finding we have asked whether other Myb-regulated genes are also associated with DNA replication origins...
  2. ncbi Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter
    Tahir H Tahirov
    Kanagawa Academy of Science and Technology, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Cell 108:57-70. 2002
    ....
  3. ncbi The chicken Pdcd4 gene is regulated by v-Myb
    U Schlichter
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Oncogene 20:231-9. 2001
    ..Our results provide the first evidence that v-Myb directly regulates the expression of a potential tumor suppressor gene...
  4. ncbi The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
    S A Ness
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 59:1115-25. 1989
    ..We conclude that mim-1 is a cellular gene that is directly regulated by the product of the v-myb oncogene...
  5. pmc Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M
    M Oelgeschlager
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    EMBO J 15:2771-80. 1996
    ..We suggest that CBP can bridge between c-Myb and NF-M, thus providing an explanation for the strong synergism between these two proteins...
  6. pmc Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    EMBO J 12:2027-38. 1993
    ..Our results suggest a role for C/EBP beta, and possibly for other C/EBP transcription factors, in v-myb function and in myeloid-specific gene activation...
  7. ncbi Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene
    M Introna
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 63:1289-97. 1990
    ..These results indicate that different forms of v-myb impose alternate phenotypes of differentiation on transformed myeloid cells, probably by regulating unique sets of differentiation-specific genes...
  8. pmc Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain
    Xianming Mo
    Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 19:2447-57. 2005
    ..Our data link a novel chromatin function of c-Myb with lineage-specific expression of differentiation genes and relate the loss of this function with the leukemic conversion of Myb...
  9. pmc v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter
    Olesya Chayka
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Strasse 2, D 48149 Munster, Germany
    Mol Cell Biol 25:499-511. 2005
    ....
  10. ncbi The chicken adenosine receptor 2B gene is regulated by v-myb
    S Worpenberg
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Oncogene 15:213-21. 1997
    ..Our results provide the first evidence that v-Myb directly regulates a gene encoding a membrane receptor and establish a link between Myb function and adenosine receptor signaling...
  11. pmc DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation
    C E Ibanez
    Department of Pathology, University of California, San Diego, La Jolla 92093 0612
    J Virol 62:4398-402. 1988
    ..This activity is not required for the nuclear localization of p48v-myb. Furthermore, the associated DNA-binding activity and nuclear localization of p48v-myb together are not sufficient for transformation...
  12. pmc Transformation by v-myb correlates with trans-activation of gene expression
    T Lane
    Department of Pathology, University of California, San Diego, La Jolla 92093
    Mol Cell Biol 10:2591-8. 1990
    ....
  13. ncbi Transformation by v-Myb
    J S Lipsick
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Oncogene 18:3047-55. 1999
    ..The E26 leukemia virus was first described in the 1960s and causes an acute erythroblastosis in chickens, more reminiscent of the disease caused by avian erythroblastosis virus (AEV) than by AMV (Ivanov et al., 1962)...
  14. ncbi Oncogenic point mutations induce altered conformation, redox sensitivity, and DNA binding in the minimal DNA binding domain of avian myeloblastosis virus v-Myb
    E M Brendeford
    Department of Biochemistry, University of Oslo, N 0316 Oslo 3, Norway
    J Biol Chem 272:4436-43. 1997
    ....
  15. pmc tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    EMBO J 16:1371-80. 1997
    ..Together with previous work our results suggest that C/EBP may be a general cooperation partner for v-Myb in myelomonocytic cells...
  16. pmc Characterization of the v-myb DNA binding domain
    T Oehler
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, FRG
    Nucleic Acids Res 18:1703-10. 1990
    ..Our results support the view that specific sequence-recognition, mediated by the conserved myb repeats, is a general feature of myb-related proteins...
  17. ncbi Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene
    Jörg Kintscher
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Oncogene 23:5807-14. 2004
    ..Apart from the identification of a novel Myb-dependent enhancer, our work demonstrates the potential of chromatin structure analysis for the identification of Myb target sites...
  18. pmc FAETL motif required for leukemic transformation by v-Myb
    S l Fu
    Department of Pathology, Stanford University, California 94305 5324, USA
    J Virol 70:5600-10. 1996
    ..Interestingly, our results show that this region is essential for the functions of v-Myb without requiring a heptad leucine repeat...
  19. pmc Estrogen-dependent alterations in differentiation state of myeloid cells caused by a v-myb/estrogen receptor fusion protein
    O Burk
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, FRG
    EMBO J 10:3713-9. 1991
    ..We have used this estrogen-dependent v-myb expression system to identify a novel v-myb regulated gene...
  20. ncbi Identification and characterization of the Myb-inducible promoter of the chicken adenosine receptor 2B gene
    Dana Kattmann
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Oncogene 21:4663-72. 2002
    ..Taken together, our data suggest that the activation of the A2B-AR promoter by Myb depends on the simultaneous binding of a large number of Myb molecules...
  21. pmc The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene
    Daniel Braas
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Nucleic Acids Res 32:4750-7. 2004
    ..We have also analysed the GAS41 replication origin in myelomonocytic cells and have failed to observe significant differences in origin activity in cells expressing or not expressing v-Myb...
  22. ncbi LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain
    Cristina B B Lira
    Departamento de Genetica, Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho UNESP, Botucatu 18618 000, SP, Brazil
    Arch Biochem Biophys 465:399-409. 2007
    ..Competition assays and chromatin immunoprecipitation confirmed the specificity of LaTBP1 for telomeric and GT-rich DNAs, suggesting that LaTBP1 is a new TBP...
  23. ncbi CBP sensitizes v-myb-transformed monoblasts to differentiation inducers
    Jana Smardova
    Department of Pathology and Anatomy, University Hospital, Jihlavska 20, 625 00 Brno, Czech Republic
    Differentiation 73:222-32. 2005
    ..These results indicate that cellular context is an important factor determining whether CBP will activate or suppress the protein it targets...
  24. ncbi Overexpression of v-myb oncogene or c-myb proto-oncogene in insect cells: characterization of newly induced nucleolus-like structures accumulating Myb protein
    Jitka Stokrova
    Department of Biopolymers Micromorphology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 37 Praha 6, Czech Republic
    Int J Mol Med 9:547-54. 2002
    ....
  25. ncbi A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts
    Eva Ondrousková
    Department of Genetics and Molecular Biology, Faculty of Science, Masaryk University, ILBIT, Pavilon A3, Kamenice 5, 625 00 Brno, Czech Republic
    Leuk Res 31:221-9. 2007
    ..We present here the first comparative proteome analysis of v-myb-transformed monoblasts BM2 focused on identification of proteins involved in their terminal differentiation...
  26. ncbi Rem-1, a putative direct target gene of the Myb-Ets fusion oncoprotein in haematopoietic progenitors, is a member of the recoverin family
    N Kraut
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Oncogene 10:1027-36. 1995
    ..Enforced expression of rem-1 in ts1.1-transformed MEP cells, using a retroviral vector, showed that this gene is not sufficient to block their differentiation, but that it may provide them with a growth advantage...
  27. ncbi TRF1, a mammalian telomeric protein
    S Smith
    Rockefeller University, New York, NY 10021, USA
    Trends Genet 13:21-6. 1997
    ..The recent isolation of TRF1, the mammalian telomeric-repeat binding factor, should now allow the structure and function of the telomeric complex to be examined in detail...
  28. ncbi A myb-related protein required for culmination in Dictyostelium
    K Guo
    Dept of Biochemistry University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Development 126:2813-22. 1999
    ..We propose that the mybC gene product is required for an intercellular signaling process controlling maturation of stalk cells and spores and that SDF-1 and/or SDF-2 may be implicated in this process...
  29. pmc The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain
    K H Klempnauer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, FRG
    EMBO J 6:2719-25. 1987
    ..This region has been highly conserved between myb genes of different species. Our results are therefore consistent with the hypothesis that DNA-binding is an important aspect of myb protein function...
  30. ncbi Mutational analysis of the transcriptional activation domains of v-Myb
    Duen Mei Wang
    Department of Pathology, Stanford University School of Medicine, Stanford, California, CA 94305 5324, USA
    Oncogene 21:1611-5. 2002
    ..In contrast, there was not a strong correlation between transcriptional activation and oncogenic transformation...
  31. pmc Telomere architecture
    Daniela Rhodes
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO Rep 3:1139-45. 2002
    ..A possibility is that telomeric proteins take up different conformations when bound to different partners, providing a simple mechanism for modulating telomere architecture...
  32. ncbi Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activation
    Silvia Monticelli
    Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Mol Immunol 38:1129-38. 2002
    ..Our results indicate that Myb proteins, which are known to act as cell cycle sensors, may play an important mechanistic role in the in vivo regulation of epsilon GL transcription in human B cells...
  33. ncbi Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:44582-9. 2004
    ..The relative resistance of v-Myb to Wnt-1-induced degradation may explain, at least in part, the differential transforming capacity of v-Myb versus c-Myb...
  34. ncbi v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells
    L Knopfova
    Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Neoplasma 55:286-93. 2008
    ..Some features of granulocytic differentiation of retinoic acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation...
  35. pmc SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression
    Silke Tillmanns
    Centre d Immunologie de Marseille Luminy CIML, Universite de la Mediterranee, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Mol Cell Biol 27:5554-64. 2007
    ..SUMO modification of lineage-specific transcription factors may thus modulate transcription factor antagonism to control tissue homeostasis in the hematopoietic system...
  36. ncbi Differential modulation of Myb family genes by Ets-2
    Anthony D Kang
    Department of Cellular Medicine and Biology, Cell and Gene Therapy Institute, Catholic University of Korea, 505, Banpo dong, Seo cho Ku, Seoul 137 701, South Korea
    Oncogene 23:4177-81. 2004
    ..These results suggest that the myb gene family can be differentially modulated by Ets-2, and that the C-terminus is the domain that regulates this activity...
  37. ncbi v-Myb represses the transcription of Ets-2
    D M Wang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Oncogene 26:1238-44. 2007
    ..In addition, we have shown that some genes that are regulated by a v-Myb-ER fusion protein may not be relevant to the biological function of the unfused v-Myb protein...
  38. ncbi c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
    E Zahradnícková
    Department of Genetics and Molecular Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Cell Mol Life Sci 60:2736-48. 2003
    ..The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation of essential cellular processes...
  39. ncbi Novel cationic transport agents for oligonucleotide delivery into primary leukemic cells
    Jarmila Kralova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 37 Prague 6, Czech Republic
    J Med Chem 46:2049-56. 2003
    ..Low toxicity, serum compatibility, and water solubility of porphyrin 3 make this compound a promising novel tool for modulation of gene expression in primary leukemic cells...
  40. pmc A temperature-sensitive phenotype of avian myeloblastosis virus: determinants that influence the production of viral mRNAs
    S Schirm
    Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143
    J Virol 64:767-73. 1990
    ..Our findings dramatize the manner in which retroviruses normally control the splicing of their RNAs and implicate the sequence of the splice acceptor site in the control...
  41. pmc Highly conserved features of DNA binding between two divergent members of the Myb family of transcription factors
    B Pinson
    Institut de Biochimie et Génétique Cellulaires, CNRS UMR5095, 1 rue Camille Saint Saens, F 33077 Bordeaux cedex, France
    Nucleic Acids Res 29:527-35. 2001
    ..e. a DNA-induced conformational change in the second repeat leads to formation of a full helix-turn-helix-related motif with the cysteine packed in the hydrophobic core of the repeat...
  42. pmc Signaling through regulated transcription factor interaction: mapping of a regulatory interaction domain in the Myb-related Bas1p
    B Pinson
    Department of Biochemistry, University of Oslo, PO Box 1041, Blindern, N 0316 Oslo 3, Norway
    Nucleic Acids Res 28:4665-73. 2000
    ..We propose a promoter-dependent model for adenine regulation in yeast based on controlled Bas1p-Bas2p interactions through BIRD and exploited differentially by the two promoters...
  43. ncbi Myb binding sites within the N-ras promoter repress transcription
    B Ganter
    Department of Pathology, Stanford University, School of Medicine, California 94305 5324, USA
    Oncogene 15:193-202. 1997
    ..The v-Myb conformation is thus suggested to play a critical role in the regulation of v-Myb activity...
  44. pmc Early reversible induction of leukotriene synthesis in chicken myelomonocytic cells transformed by a temperature-sensitive mutant of avian leukemia virus E26
    A J Habenicht
    University of Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 86:921-4. 1989
    ..These results indicate that activation of the 5-lipoxygenase pathway is a very early event in the macrophage differentiation pathway that is directly or indirectly controlled by the temperature-sensitive v-myb protein...
  45. pmc Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins
    K Weston
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Nucleic Acids Res 20:3043-9. 1992
    ..The results show that the original consensus binding site defined for v-Myb, YAA-CKG, can be extended to YAACKGHH, and that this new consensus holds for both v-Myb and chicken c-Myb...
  46. ncbi Identification of genes differentially expressed in two types of v-myb-transformed avian myelomonocytic cells
    T Nakano
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Oncogene 7:527-34. 1992
    ..Co-transfection experiments of a reporter construct containing the promoter of the ribonuclease A-related gene indicated that this promoter is regulated by the v-Myb oncoprotein without the involvement of Myb-specific binding sequences...
  47. pmc Transformation of chicken myelomonocytic cells by a retrovirus expressing the v-myb oncogene from the long terminal repeats of avian myeloblastosis virus but not Rous sarcoma virus
    R D Press
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104 4268
    J Virol 66:5373-83. 1992
    ....
  48. pmc Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus
    U Stober-Grässer
    Department of Pathology, University of California, San Diego, La Jolla 92093
    J Virol 62:1093-6. 1988
    ..We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformation of myeloblasts by v-myb...
  49. pmc Nucleotide sequence of cDNA clones of the murine myb proto-oncogene
    T J Gonda
    EMBO J 4:2003-8. 1985
    ..This comparison suggested that the rearranged c-myb gene may encode a protein which, like the v-myb protein, lacks the N-terminal region of c-myb...
  50. ncbi v-myb transformation of Xeroderma pigmentosum human fibroblasts: overexpression of the c-Ha-ras oncogene in the transformed cells
    S Michelin
    Laboratoire de Genetique Moleculaire, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
    Exp Cell Res 196:314-22. 1991
    ..1 G). Our results lead to the conclusion that the XP fibroblasts are phenotypically transformed by the presence of the transfected v-myb oncogene, which is able to induce an overexpression of the c-Ha-ras gene...
  51. ncbi Mapping of a small phosphopeptide at the carboxyterminus of the viral myb protein by monoclonal antibodies
    H Bading
    Max Planck Institut fur Molekulare Genetik, Berlin, Federal Republic of Germany
    Oncogene 4:33-8. 1989
    ....
  52. ncbi Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes
    Michael Korenjak
    Lehrstuhl für Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munchen, Germany
    Cell 119:181-93. 2004
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure...
  53. ncbi Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells
    Alice Nemajerova
    Masaryk Memorial Cancer Institute, Brno, Czech Republic
    J Hematother Stem Cell Res 12:225-35. 2003
    ..This suggests that chromatin remodeling can be significantly engaged in regulation of proliferation and differentiation of leukemic cells...
  54. ncbi Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb
    F Liu
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Oncogene 25:795-805. 2006
    ..The results suggest that v-Myb is not just a de-repressed version of c-Myb. Instead, it is a distinct transcriptional regulator with a unique set of activities...
  55. pmc Individual repeats of Drosophila Myb can function in transformation by v-Myb
    X Bin
    Department of Microbiology, State University of New York, Stony Brook 11794 5222
    J Virol 67:7332-9. 1993
    ..These results demonstrate that although the protein-DNA contacts made by the Myb repeats have been conserved during the evolution of animals, the protein-protein interactions have diverged...
  56. ncbi Role of vimentin in regulation of monocyte/macrophage differentiation
    Petr Benes
    Department of Genetics and Molecular Biology, Faculty of Science Masaryk University ILBIT, Pavilion A3, Kamenice 3, 62500 Brno, Czech Republic
    Differentiation 74:265-76. 2006
    ..Taken together, these findings document that up-regulation of vimentin gene expression is important for formation of fully active macrophage-like cells and macrophage polykaryons...
  57. ncbi Production of v-Myb and c-Myb in insect cells infected with recombinant baculoviruses
    K Vranovský
    Czechoslovak Academy of Sciences, Institute of Molecular Genetics, Prague
    Gene 117:233-5. 1992
    ..The system provides a convenient source of relatively large amounts of v-Myb or c-Myb for in vitro binding studies...
  58. ncbi Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus
    T Metz
    Differentiation Programme European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 66:95-105. 1991
    ..These results show that v-Myb and v-Ets must be fused to cause leukemia and establish a new mechanism of oncogene activation and cooperation...
  59. pmc Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor
    C Garrido
    Cancer Research Institute, University of California Medical Center, San Francisco 94143 0128
    J Virol 66:160-6. 1992
    ....
  60. ncbi v-erbA oncogene abrogates growth inhibition of chicken embryo fibroblasts induced by retinoic acid
    C Desbois
    , , , Lyon, France
    Oncogene 6:2129-35. 1991
    ..These data strongly suggest functional interferences between the retinoic acid receptors and the AP-1 transcription factor complex in the control of expression of genes involved in CEF proliferation...
  61. pmc Myb proteins inhibit fibroblast transformation by v-Rel
    Shu Ling Fu
    Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Mol Cancer 5:54. 2006
    ..These results imply that the myb genes can function either as oncogenes or as tumor suppressors in different cellular contexts...
  62. pmc Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    Tim C P Somervaille
    Department of Pathology, Stanford University, Stanford, CA 94305, USA Cancer Research UK Leukaemia Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Cell Stem Cell 4:129-40. 2009
    ....
  63. pmc Transcriptional regulation of an iron-inducible gene by differential and alternate promoter entries of multiple Myb proteins in the protozoan parasite Trichomonas vaginalis
    Hong Ming Hsu
    Division of Infectious Diseases, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Eukaryot Cell 8:362-72. 2009
    ..Together, these results suggest that Myb2 and Myb3 may coactivate basal and iron-inducible ap65-1 transcription against Myb1 through conditional and competitive promoter entries...
  64. pmc A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding
    Emily Ray Ko
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Mol Cancer 7:77. 2008
    ..Instead, these acidic residues are required for efficient chromatin binding and interaction with the histone H4 N-terminal tail...
  65. pmc Functional antagonism between members of the myb family: B-myb inhibits v-myb-induced gene activation
    G Foos
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Frieburg, Germany
    EMBO J 11:4619-29. 1992
    ..Our results raise the possibility that B-myb is an inhibitory member of the myb family...
  66. ncbi Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana
    Iva Mozgová
    Department of Functional Genomics and Proteomics, Institute of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, CZ 62500 Brno, Czech Republic
    Phytochemistry 69:1814-9. 2008
    ..We show that preferential interaction of AtTRB1 with double-stranded telomeric DNA is mediated by the Myb domain, while the H1/5 domain is involved in non-specific DNA-protein interaction and in the multimerization of AtTRB1...
  67. ncbi Role of the cold shock domain protein A in the transcriptional regulation of HBG expression
    Raffaella Petruzzelli
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Naples, Italy
    Br J Haematol 150:689-99. 2010
    ..Therefore, our study demonstrated that CSDA is a trans-acting repressor factor of HBG expression and modulates the HPFH phenotype...
  68. pmc C/EBPbeta induces chromatin opening at a cell-type-specific enhancer
    Annette Plachetka
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Mol Cell Biol 28:2102-12. 2008
    ..Our work identifies a novel function for C/EBPbeta in the initial steps of a localized chromatin opening at a specific, physiologically relevant target region...
  69. pmc Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene
    Olga Ivanova
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Strasse 2, D 48149 Munster, Germany
    Nucleic Acids Res 35:7237-47. 2007
    ..Our data demonstrate for the first time that oncogenic activation of Myb alters its DNA-binding specificity at a physiological Myb target gene...
  70. ncbi Melanocyte fate in neural crest is triggered by Myb proteins through activation of c-kit
    V Karafiat
    Department of Molecular Virology, Institute of Molecular Genetics, AS CR v v i, Videnska 1083, Prague 4, 14220, Czech Republic
    Cell Mol Life Sci 64:2975-84. 2007
    ....
  71. ncbi A dual activation mechanism for Myb-responsive genes in myelomonocytic cells
    Vichanan Yamkamon
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Str 2, D 48149 Munster, Germany
    Blood Cells Mol Dis 40:219-26. 2008
    ..Our results show that C/EBPalpha expression is down-regulated by v-Myb. Thus, v-Myb affects the expression of two C/EBP family members in opposite directions...
  72. ncbi VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection
    Paul J Sheridan
    Cardiovascular Research Unit, Division of Clinical Sciences North, Clinical Sciences Centre, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK
    J Gene Med 7:375-85. 2005
    ....
  73. ncbi Cloning and nucleotide sequence of the 5' part of v-myb cDNA
    P Bartunek
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    Virology 190:882-3. 1992
    ..The leader is a novel variant of known avian retrovirus leaders. The long open reading frame in the cloned cDNA starts with six gag-derived codons spliced to the myb-specific sequence...
  74. ncbi p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
    Jarmila Navrátilová
    Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Differentiation 75:592-604. 2007
    ..The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controlling apoptosis and differentiation/proliferation are independent...
  75. ncbi Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q)...
  76. pmc Transcription of the chicken myb proto-oncogene starts within a CpG island
    M Dvorak
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    Nucleic Acids Res 17:5651-64. 1989
    ..Moreover, consensus v-myb protein DNA-binding sites were revealed in the promoter region and in sequences downstream from it...
  77. ncbi The myb oncogene
    J S Lipsick
    Jonsson Comprehensive Cancer Center, University of California, School of Medicine, Los Angeles 90024
    Gene Amplif Anal 4:73-98. 1986
    ....
  78. ncbi The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors
    V Karafiat
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    Blood 98:3668-76. 2001
    ..It is proposed that Myb LZR can function as a molecular switch, affecting expression of lineage-specifying transcription factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages...
  79. ncbi Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro
    E M Brendeford
    Department of Biochemistry, University of Oslo, Norway
    FEBS Lett 425:52-6. 1998
    ..This difference in NO sensitivity may influence the regulation of wild type versus AMV v-Myb protein function...
  80. ncbi Bicistronic retroviral vector reveals capacity of v-erbA to induce erythroleukemia and to co-operate with v-myb
    T Casini
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Oncogene 11:1019-26. 1995
    ....
  81. ncbi Weak transcriptional activation is sufficient for transformation by v-Myb
    U Engelke
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Virology 208:467-77. 1995
    ....
  82. ncbi Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein
    P Kaspar
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo 2, 166 37 Prague 6, Czech Republic
    J Biol Chem 274:14422-8. 1999
    ..Our data reveal Myb proteins as the first ATBF1 partners detected so far and identify amino acids 279-300 in v-Myb as a novel protein-protein interaction interface through which Myb transcriptional activity can be regulated...
  83. ncbi CDK-independent activities of D type cyclins
    R Bernards
    Division of Molecular Carcinogenesis, Center for Biomedical Genetics, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Biochim Biophys Acta 1424:M17-22. 1999
  84. ncbi The fit-1 common integration locus in human and mouse is closely linked to MYB
    N I Barr
    Molecular Oncology Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Mamm Genome 10:556-9. 1999
    ..However, the cluster of viral insertion loci in this region suggests either the presence of a closely linked activation target or that subtle effects on Myb have been overlooked...
  85. pmc Interaction and functional collaboration of p300 and C/EBPbeta
    S Mink
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mol Cell Biol 17:6609-17. 1997
    ....
  86. pmc Determination of the molecular weight of DNA-bound protein(s) responsible for gel electrophoretic mobility shift of linear DNA fragments examplified with purified viral myb protein
    H Bading
    Max Planck Institut fur Molekulare Genetik, Abt Schuster, Berlin, FRG
    Nucleic Acids Res 16:5241-8. 1988
    ..As an example this calculation was used in order to analyse DNA-binding of the isolated viral myb protein. It could be demonstrated that the viral myb protein binds to DNA as a monomer and as a dimer...
  87. ncbi The Myb oncoprotein: regulating a regulator
    S A Ness
    Northwestern University, Department of Biochemistry, Molecular Biology and Cell Biology, Evanston, IL 60208 3500, USA
    Biochim Biophys Acta 1288:F123-39. 1996
  88. ncbi Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1
    K Noben-Trauth
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 35:610-2. 1996
    ..However, our findings are in contrast to a previous report by Barletta et al. (Cancer Res. 51:3821-3824, 1991) that placed the MYBL2 gene on human chromosome Xq13...
  89. ncbi Association of v-myc protein with chromatin
    K H Klempnauer
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Oncogene 4:115-8. 1989
    ..v-myb and v-myc proteins thus share the same subnuclear location and apparently interact directly with the cellular DNA...
  90. ncbi Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein
    Paul A Bartley
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
    Oncogene 22:7570-5. 2003
    ....
  91. pmc Silent point mutation in an avian retrovirus RNA processing element promotes c-myb-associated short-latency lymphomas
    Tatjana S Polony
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Virol 77:9378-87. 2003
    ..Thus, we propose that disruption of the NRS sequence promotes readthrough transcription and splicing to the downstream myb gene, causing overexpression of a slightly truncated Myb protein, which induces short-latency tumors...
  92. ncbi Myb-induced transformation
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Crit Rev Oncog 7:245-60. 1996
    ..Although c-myb's involvement in human leukemia has been suggested, it has never been clearly established and should be investigated further...
  93. pmc Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro
    T J Gonda
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 8:1777-83. 1989
    ....
  94. ncbi Cloning and identification of a novel cDNA coding thioredoxin-related transmembrane protein 2
    Xianfang Meng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Biochem Genet 41:99-106. 2003
    ..Northern blot analysis shows it is widely expressed in human tissues...
  95. ncbi Association of decreased expression of a Myb transcription factor with the TPD (tapping panel dryness) syndrome in Hevea brasiliensis
    Shoucai Chen
    National Key Biotechnology Laboratory of Tropical Crops, CATAS, Hainan, 571101, China
    Plant Mol Biol 51:51-8. 2003
    ..Our results suggest that the expression of HbMyb1 is likely associated with TPD and that the function of HbMyb1 is associated with the integrity of bark tissue of rubber trees...
  96. ncbi The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts
    S Sif
    Department of Biology, Boston University, Massachusetts 02215
    Oncogene 8:2501-9. 1993
    ..These results suggest that certain oncoproteins might increase transcription from many genes that contain Sp1 binding sites, and that this might be important for certain aspects of transformation by these proteins...
  97. ncbi TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM
    E Seroussi
    Department of Molecular Medicine, Karolinska Hospital, CMM Building, L8 00, Stockholm, S 171 76, Sweden
    Genomics 57:380-8. 1999
    ..Using a genomic PAC clone, we demonstrate that the mouse Tom1 and Hmox1 genes are part of an as yet undescribed syntenic group between mouse chromosome 8C1 and human chromosome 22q13.1...
  98. pmc Avian erythroblastosis virus E26: only one (myb) of two cell-derived coding regions is necessary for oncogenicity
    Y Wu
    Department of Molecular and Cell Biology, University of California at Berkeley 94720
    Proc Natl Acad Sci U S A 91:4039-43. 1994
    ..Viral ets probably reflects a genetic accident that transduced sequences of proto-ets together with proto-myb in generating E26...
  99. ncbi Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBPalpha or C/EBPbeta and tom-1A promoter fragment
    T H Tahirov
    Kanagawa Academy of Science and Technology KAST, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Acta Crystallogr D Biol Crystallogr 57:1655-8. 2001
    ..Complete diffraction data sets were obtained from each native crystal and two types of iodine-derivative crystals. A three-wavelength MAD data set was also obtained from a bromine-derivative crystal...
  100. ncbi bFGF signaling and v-Myb cooperate in sustained growth of primitive erythroid progenitors
    Petr Bartunek
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo n 2, 166 37 Prague 6, Czech Republic
    Oncogene 21:400-10. 2002
    ..These findings unravel a so far unidentified link between extracellular signaling and Myb in hematopoietic cells...
  101. ncbi Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    Kuniyoshi Iwabuchi
    Department of Biochemistry, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku gun, Ishikawa 920 0293, Japan
    J Biol Chem 278:36487-95. 2003
    ..This domain also stimulated end-joining by DNA ligase IV/Xrcc4, but not by T4 DNA ligase in vitro. We conclude that 53BP1 has the potential to participate directly in the repair of DNA double-strand breaks...

Research Grants1

  1. ONCOGENIC ACTIVATION OF MYB FAMILY PROTEINS
    Joseph Lipsick; Fiscal Year: 2003
    ..We propose to develop a cell culture assay for transformation by this activated form of c-Myb and to investigate its biochemical and biological properties. ..