interleukin 13

Summary

Summary: T-lymphocyte-derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-lymphocytes. It appears to play a role in regulating inflammatory and immune responses.

Top Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
  3. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  4. ncbi Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
    Laura J Cliffe
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Science 308:1463-5. 2005
  5. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
  6. pmc Pulmonary fibrosis: pathogenesis, etiology and regulation
    M S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mucosal Immunol 2:103-21. 2009
  7. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998
  8. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
  9. ncbi Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Rev 201:139-55. 2004
  10. pmc Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA
    J Clin Invest 113:1490-7. 2004

Research Grants

Detail Information

Publications325 found, 100 shown here

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  2. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..IL-13 may play an important role in the pathogenesis of similar responses in asthma or other Th2-polarized tissue responses...
  3. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  4. ncbi Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
    Laura J Cliffe
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Science 308:1463-5. 2005
    ..This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense...
  5. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
  6. pmc Pulmonary fibrosis: pathogenesis, etiology and regulation
    M S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mucosal Immunol 2:103-21. 2009
    ..Restoring homeostasis to these dysregulated healing responses, or simply neutralizing the key pro-fibrotic mediators may prevent or slow the progression of pulmonary fibrosis...
  7. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998
    ..Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases...
  8. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
    ..We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion...
  9. ncbi Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Rev 201:139-55. 2004
    ....
  10. pmc Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA
    J Clin Invest 113:1490-7. 2004
    ..These studies show that UC is associated with an atypical Th2 response mediated by nonclassical NKT cells producing IL-13 and having cytotoxic potential for epithelial cells...
  11. ncbi IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    J F Urban
    United States Department of Agriculture, Beltsville, Maryland 20705, USA
    Immunity 8:255-64. 1998
    ..Additional observations made in the course of these experiments demonstrate that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL-4-induction of mucosal mastocytosis...
  12. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
    ..Thus, our findings provide evidence that IL-13 inhibitors may be of general therapeutic benefit in preventing damaging tissue fibrosis resulting from Th2-dominated inflammatory responses...
  13. ncbi IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    Padraic G Fallon
    Immunomodulation Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Immunity 17:7-17. 2002
    ..These mice reveal distinct spatial, temporal, and hierarchical cytokine requirements in immune function...
  14. ncbi Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
    Kanwarpal S Kahlon
    Division of Molecular Medicine, Beckman Research Institute, Departments of Pediatric Hematology Oncology, City of Hope National Medical Center, Duarte, California, USA
    Cancer Res 64:9160-6. 2004
    ..Our IL13-zetakine is a prototype of a new class of chimeric immunoreceptors that signal through an engineered immune synapse composed of membrane-tethered cytokine muteins bound to cell-surface cytokine receptors on tumors...
  15. ncbi A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 31:1515-21. 2001
    ..Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. The relationship of this marker with sensitization to individual aeroallergens has not been evaluated...
  16. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  17. pmc Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
    C L Emson
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    J Exp Med 188:399-404. 1998
    ..These data indicate that expression of IL-13 transgenes in vivo can regulate IgE production in the mouse, and that IL-13 may also influence thymocyte development...
  18. ncbi Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  19. ncbi Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom and Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:2585-91. 2000
    ..Therefore, we demonstrate that during a dynamic type 2 cytokine disease process IL-13 is detrimental to survival following infection, whereas IL-4 is beneficial...
  20. ncbi Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    Frank Heller
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:629-38. 2002
    ..These data thus describe a cellular mechanism underlying an experimental colitis that may explain the pathogenesis of ulcerative colitis...
  21. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    ..Together, this shows that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation...
  22. ncbi A distinct role for interleukin-13 in Th2-cell-mediated immune responses
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 8:339-42. 1998
    ..These data support a unique role for IL-13 in Th2-cell-mediated immune responses and demonstrate that IL-13 and IL-4 are not redundant...
  23. ncbi Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses
    A Minty
    Sanofi Elf Bio Recherches, Labege, France
    Nature 362:248-50. 1993
    ..Recent mapping of the IL-13 gene shows that it is closely linked to the IL-4 gene on chromosome 5q 23-31 (ref. 4). Interleukin-13 may be critical in regulating inflammatory and immune responses...
  24. pmc Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
    T Zheng
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 106:1081-93. 2000
    ..They also demonstrate that IL-13 causes emphysema via a MMP- and cathepsin-dependent mechanism(s) and highlight common mechanisms that may underlie COPD and asthma...
  25. ncbi IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    Hazel C Atherton
    Novartis Respiratory Research Centre, Wimblehurst Rd, Horsham, West Sussex RH12 5AB, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 285:L730-9. 2003
    ..These data support the concept that IL-13 is in part able to induce a mucus hypersecretory phenotype through a direct interaction with the airway epithelium and that MAP kinase and PtdIns 3-kinase signaling pathways are involved...
  26. ncbi TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells
    Hironori Matsushima
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Immunol 173:531-41. 2004
    ....
  27. ncbi IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
    M G Chiaramonte
    Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:920-30. 1999
    ..Together, these data demonstrate that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs...
  28. ncbi Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
    Sarah J Ballantyne
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Allergy Clin Immunol 120:1324-31. 2007
    ..Its roles in antigen-driven airway inflammation and airway hyperresponsiveness (AHR) remain to be fully established...
  29. ncbi Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 Pseudomonas exotoxin in pancreatic cancer therapy
    Takeshi Shimamura
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Clin Cancer Res 16:577-86. 2010
    ..However, its significance and expression in pancreatic cancer is not known. It is also not known whether IL-13 can signal through IL-13Ralpha2 in cancer...
  30. ncbi Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    Andre Gessner
    Institute of Clinical Microbiology, Immunology, and Hygiene University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 174:1063-72. 2005
    ..These novel findings have important implications for the prevention and therapeutic intervention of allergic and asthmatic diseases...
  31. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  32. pmc Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
    Monica G Chiaramonte
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:687-701. 2003
    ..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
  33. ncbi IL-13 receptors and signaling pathways: an evolving web
    Gurjit K Khurana Hershey
    Division of Allergy, and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    J Allergy Clin Immunol 111:677-90; quiz 691. 2003
    ..This review will summarize the current understanding of the IL-13 receptors and signaling pathways, emphasizing recent observations...
  34. pmc Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling
    Sophie Lanone
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 110:463-74. 2002
    ..The also demonstrate that MMPs-9 and -12 play different roles in the generation of IL-13-induced inflammation, with MMP-9 inhibiting neutrophil accumulation and MMP-12 contributing to the accumulation of eosinophils and macrophages...
  35. ncbi Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine and Center for Gene Therapeutics, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:526-35. 2002
    ....
  36. ncbi Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis
    Claudia Jakubzick
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Immunol Res 30:339-49. 2004
    ....
  37. ncbi Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    S Agarwal
    Department of Pathology, Harvard Medical School, Center for Blood Research, Boston, Massachusetts 02115, USA
    Immunity 9:765-75. 1998
    ..We propose that chromatin remodeling of cytokine gene loci is functionally associated with productive T cell differentiation and may explain the coordinate regulation of Th2 cytokine genes...
  38. ncbi Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
    M Barner
    Basel Institute for Immunology, Switzerland
    Curr Biol 8:669-72. 1998
    ..Injection of recombinant IL-13 induced worm expulsion in otherwise incompetent RAG2-/- mice. Our results suggest that IL-13 regulates Th2 responses to nematode infection and requires IL-4R alpha...
  39. pmc Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    C G Lee
    Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, New Haven, CT 06520 8057, USA
    J Exp Med 194:809-21. 2001
    ..They also demonstrate that this activation is mediated by a plasmin/serine protease- and MMP-9-dependent and CD44-independent mechanism(s) and that the fibrogenic effects of IL-13 are mediated, in great extent, by this TGF-beta pathway...
  40. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
    ..An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production...
  41. ncbi IL-13 is a susceptibility factor for Leishmania major infection
    D J Matthews
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:1458-62. 2000
    ..Furthermore, using BALB/c mice deficient in the expression of IL-4, IL-13, or both IL-13 and IL-4, we demonstrate that IL-13-deficient mice are resistant to infection and that there is an additive effect of deleting both IL-4 and IL-13...
  42. ncbi Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Respir Cell Mol Biol 27:419-27. 2002
    ..This suggests that IL-13 has a role in the development of pulmonary fibrosis that is independent of its direct effect on fibroblasts and is evidence for an interaction between Th2 cytokines and specific CC chemokines...
  43. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..These data suggest that IL-13Ralpha(2) signaling during prolonged inflammation is an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis...
  44. ncbi Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin
    W Debinski
    The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Department of Surgery, Division of Neurosurgery, Hershey, Pennsylvania 17033, USA
    Clin Cancer Res 1:1253-8. 1995
    Recently, we have demonstrated that a spectrum of human adenocarcinoma cell lines express binding sites for interleukin 13 (IL-13)...
  45. ncbi CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    Omid Akbari
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 354:1117-29. 2006
    ..Because mouse models of allergic asthma indicate that natural killer T cells are required for the development of allergen-induced airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human asthma...
  46. ncbi IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
    ..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown...
  47. ncbi Signaling and transcription in T helper development
    K M Murphy
    Department of Pathology, and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Immunol 18:451-94. 2000
    ..In addition several new mediators of control have emerged, including IL-18, the intriguing Th2-selective T1/ST2 product, and heterogeneity in dendritic cells capable of directing cytokine-independent Th development...
  48. ncbi In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells
    T Hoshino
    Laboratory of Experimental Immunology, DBS, NCI FCRDC, Frederick, USA
    Eur J Immunol 30:1998-2006. 2000
    ..1 mAb. These results suggest that IL-18 can induce Th2 cytokines and CD154 expression, and can contribute to CD4+ T cell-dependent, IL-4-independent IgE production...
  49. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity...
  50. ncbi IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 120:1292-300. 2007
    ..Early studies have established that esophageal eosinophilia occurs in association with T(H)2 allergic responses, and we recently identified an EE-specific esophageal transcriptome that included eotaxin-3...
  51. ncbi Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells
    Luzheng Xue
    Oxagen Limited, Abingdon, Oxon, United Kingdom
    J Immunol 175:6531-6. 2005
    ....
  52. pmc Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma
    Kate Blease
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 160:481-90. 2002
    ..Taken together, these data demonstrate that the chronic development of airway hyperresponsiveness during fungal asthma is IL-13-dependent but Stat6-independent...
  53. ncbi A critical role for IL-13 in resistance to intestinal nematode infection
    A J Bancroft
    School of Biological Science, University of Manchester, United Kingdom
    J Immunol 160:3453-61. 1998
    ..The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths...
  54. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  55. ncbi Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease
    Y Wang
    Centre for Transplantation and Renal Research, The University of Sydney at Westmead Millennium Institute, Westmead, New South Wales, Australia
    Kidney Int 72:290-9. 2007
    ..Our findings demonstrate that macrophages not only act as effectors of immune injury but can be induced to provide protection against immune injury...
  56. ncbi Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
    Zhou Zhu
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street, TAC S 441, New Haven, CT 06520 8057, USA
    Science 304:1678-82. 2004
    ..AMCase may thus be an important mediator of IL-13-induced responses in Th2-dominated disorders such as asthma...
  57. ncbi cDNA cloning and characterization of the human interleukin 13 receptor alpha chain
    M J Aman
    Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    J Biol Chem 271:29265-70. 1996
    We have cloned cDNAs corresponding to the human interleukin 13 receptor alpha chain (IL-13Ralpha). The protein has 76% homology to murine IL-13Ralpha, with 95% amino acid identity in the cytoplasmic domain...
  58. pmc Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
    Sima Allahverdian
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 38:153-60. 2008
    ..Dysregulation of EGFR phosphorylation may contribute to a persistent repair phenotype and chronically increased IL-13 release, and in turn result in airway remodeling...
  59. ncbi Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes
    Elena Llanes
    Servicio de Inmunologia, Fundacion Jimenez Diaz Capio, CIBERES ISCIII, Madrid, Spain
    Int Arch Allergy Immunol 148:228-38. 2009
    ....
  60. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
    ..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...
  61. ncbi Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population
    T D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Respir Cell Mol Biol 25:377-84. 2001
    ..Further investigation is required to determine which specific alleles or combination of alleles contribute to these phenotypes, and the possible downstream effects of the resulting change in IL-13 levels or activity...
  62. pmc IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells
    J Laoukili
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, , Paris, France
    J Clin Invest 108:1817-24. 2001
    ..These results suggest that, in human allergic asthmatic responses, IL-13 affects both ciliated and secretory cell differentiation, leading to airway damage and obstruction...
  63. pmc Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy
    Joseph Donfack
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Respir Res 6:145. 2005
    ..Evolutionarily conserved sequences likely have biological function...
  64. ncbi IL-13 effector functions
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 21:425-56. 2003
    ..This review highlights the effector functions of IL-13 and describes multiple pathways for modulating its activity in vivo...
  65. ncbi Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma
    Renske W B Bottema
    Department of Pulmonology, University Medical Center, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 153:259-67. 2010
    ..IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinitis has not been extensively studied...
  66. ncbi Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types
    J H Lee
    Lung Biology Center, Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA 94143, USA
    Am J Respir Cell Mol Biol 25:474-85. 2001
    ..These results suggest that the in vivo response to IL-13 in the airways likely results from a combination of distinct effects on each of several resident airway cell types...
  67. ncbi Structure, binding, and antagonists in the IL-4/IL-13 receptor system
    Thomas D Mueller
    Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, Germany
    Biochim Biophys Acta 1592:237-50. 2002
    ..Based on these new data, the hitherto elusive goal of designing small molecular mimetics may be feasible...
  68. pmc Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines
    C S Cleaver
    Department of Rheumatology, School of Clinical and Medical Sciences, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Ann Rheum Dis 60:150-7. 2001
    To investigate whether interleukin 13 (IL13) could act in a chondroprotective manner and protect cartilage stimulated to resorb with a combination of IL1alpha and oncostatin M (OSM), in a similar way to the anti-inflammatory cytokine, IL4.
  69. pmc Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis
    A Spadaro
    Department of Medical Therapy, Rheumatology Unit, University of Rome La Sapienza, Italy
    Ann Rheum Dis 61:174-6. 2002
    ....
  70. ncbi IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
    M M Grunstein
    Division of Pulmonary Medicine, Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 282:L520-8. 2002
    ....
  71. ncbi Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains
    J G Zhang
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 272:9474-80. 1997
    ..Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo...
  72. pmc Fibrotic disease and the T(H)1/T(H)2 paradigm
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6154, MSC 8003, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 4:583-94. 2004
  73. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  74. ncbi Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro
    Bibo Ke
    Dumont UCLA Transplant Center, Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Hum Gene Ther 13:1845-57. 2002
    This study analyzes mechanisms by which interleukin 13 (IL-13) affects "infectious tolerance" in rat recipients of cardiac allografts, with emphasis on interactions between intragraft Ad-IL-13 gene transfer and systemic infusion of ..
  75. ncbi Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism
    Hanan S M Farghaly
    Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
    Mol Pharmacol 73:1530-7. 2008
    ..In addition to previously reported effects on airway inflammation, inhibition of PI3K p110delta may be a useful target for the treatment of asthma by preventing IL-13-induced airway smooth muscle hyper-responsiveness...
  76. ncbi Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    J Immunol 159:4506-13. 1997
    ....
  77. ncbi Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    B Boris Vargaftig
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur INSERM U485, Paris, France
    Am J Respir Cell Mol Biol 28:410-9. 2003
    ..LT also induced the vascular endothelium remodelling and collagen deposition. Overall, our results demonstrate the major involvement of LT in the effects of IL-13 on the lung...
  78. pmc Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway
    Michael R Blackburn
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Texas, USA
    J Clin Invest 112:332-44. 2003
    ..They also demonstrate that IL-13 and adenosine stimulate one another in an amplification pathway that may contribute to the nature, severity, progression, and/or chronicity of IL-13 and/or Th2-mediated disorders...
  79. ncbi V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function
    Kimberly A Risma
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:1604-10. 2002
    ..These data illustrate the importance of studying snps in combination, because the functional significance of a given snp may only be evident in a specific setting of additional snps in the same or different genes...
  80. ncbi IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response
    T Hoshino
    Laboratory of Experimental Immunology, Division of Basic Sciences, National Cancer Institute, Frederick Cancer and Research Development Center, MD 21702, USA
    J Immunol 162:5070-7. 1999
    ..Thus, depending upon the cell type, IL-18 may act as a strong coinducer of Th1 or Th2 cytokines. Our findings suggest that IL-12 and IL-18 have different roles in the regulation of gene expression in NK and T cells...
  81. ncbi Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: relationship to interleukin 13 gene polymorphism
    Shinsuke Homma
    Department of Pulmonary Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:933-9. 2006
    ..00048). Thus, SNP13 and haplotypes, SNP7 G/A and IL13 +2044 G/A, may be useful for predicting COPD susceptibility...
  82. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ....
  83. ncbi Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells
    Henry Danahay
    Novartis Respiratory Research Centre, Horsham, West Sussex RH12 5AB, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 282:L226-36. 2002
    ..The results indicate that IL-13 converts the human bronchial epithelium from an absorptive to a secretory phenotype that is the result of loss of amiloride-sensitive current and an increase in a DIDS-sensitive apical anion conductance...
  84. ncbi Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response
    Motoko Morimoto
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 172:2424-30. 2004
    ....
  85. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  86. pmc Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    Jeffrey W Tyner
    Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:309-21. 2006
    ....
  87. ncbi The role of interleukin-13 in infectious diseases and allergy
    F Brombacher
    University of Cape Town, Groote Schuur Hospital, Medical Faculty Immunology Department, Cape Town, South Africa
    Bioessays 22:646-56. 2000
    ..If this scenario holds true in humans, we soon may have an efficient drug for treatment of IL-13-mediated diseases...
  88. ncbi Il-13 and IFN-gamma: interactions in lung inflammation
    J G Ford
    Department of Medicine, Harlem Hospital Center, Harlem Lung Center, Columbia University, New York, NY 10037, USA
    J Immunol 167:1769-77. 2001
    ..In conclusion, IFN-gamma has double-sided effects (inhibiting some, potentiating others) on IL-13-induced changes in the lungs. This may be the reason for the ambiguous role of Th1 responses on Th2 response-induced lung injury...
  89. pmc Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection
    D Artis
    Immunology Group, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Exp Med 190:953-62. 1999
    ..These results provide the first demonstration of the role of TNF-alpha in regulating Th2 cytokine-mediated responses at mucosal sites, and have implications for the design of rational therapies against helminth infection and allergy...
  90. ncbi Characterization of the interaction between interleukin-13 and interleukin-13 receptors
    Kazuhiko Arima
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Saga 849 8501, Japan
    J Biol Chem 280:24915-22. 2005
    ..These results provide the basis for a precise understanding of the interaction between IL-13 and its receptors...
  91. ncbi Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways
    Atsuko Kibe
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Crit Care Med 167:50-6. 2003
    ..Control of steroid-resistant features induced by IL-13, including AHR and mucus production, may provide new therapeutic modalities for asthma...
  92. ncbi Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism
    S Matsukura
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:755-61. 2001
    ..These results indicate that IL-13 stimulates eotaxin expression in airway epithelial cells and that STAT6 plays a pivotal role in this response...
  93. ncbi The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma
    A Richter
    Respiratory, Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 25:385-91. 2001
    ..In contrast, direct activation of submucosal fibroblasts by IL-4 and IL-13 has a proinflammatory effect via eotaxin release and recruitment of eosinophils into the airways...
  94. ncbi Final steps of natural killer cell maturation: a model for type 1-type 2 differentiation?
    M J Loza
    Kimmel Cancer Center, Jefferson Medical College, Department of Microbiology and Immunology, Philadelphia, PA, USA
    Nat Immunol 2:917-24. 2001
    Analysis of cytokine and differentiation antigen expression in human natural killer (NK) cells revealed that interleukin 13 (IL-13) and interferon gamma (IFN-gamma) are produced at sequential stages during irreversible IL-12-induced ..
  95. pmc ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo
    Patty J Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 116:163-73. 2006
    ..ERK1/2 regulators may be useful in the treatment of IL-13-induced diseases and disorders...
  96. ncbi Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease
    Paul S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200 Australia
    Pharmacol Ther 94:253-64. 2002
    ..While promising, newer therapies face a gauntlet of developmental challenges, but offer the hope of reducing allergic diseases once again to minor public health concerns...
  97. ncbi IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9
    M Stassen
    Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 166:4391-8. 2001
    ....
  98. ncbi Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma
    Fei Huang
    Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Davis, Calif 95616, USA
    J Allergy Clin Immunol 121:1415-21, 1421.e1-3. 2008
    ..IL-19 plays a significant role in the enhancement of T(H)2 cytokine secretion in allergic diseases, but its cellular source in asthmatic patients remains unknown...
  99. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  100. ncbi Genetic variants of IL-13 signalling and human asthma and atopy
    A Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Hum Mol Genet 9:549-59. 2000
    ..38 in males, 1.10 in females) rather than asthma. Thus, certain variants of IL-13 signalling are likely to be important promoters of human asthma; detailed functional analysis of their actions is needed...
  101. ncbi IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
    Zhou Zhu
    Section of Pulmonary and Critical Care Medicine, Departments of Internal Medicine and Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:2953-62. 2002
    ..These studies demonstrate that IL-13 is a potent stimulator of MCPs and other CC chemokines and document the importance of MCP-CCR2 signaling in the pathogenesis of the IL-13-induced pulmonary phenotype...

Research Grants65

  1. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2013
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  2. Regulating the Immune Microenvironment in Breast Cancer
    Lisa Marie Coussens; Fiscal Year: 2013
    ....
  3. Allergic Condition Susceptibility Polymorphisms and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2012
    ..Data will be analyzed using logistic and Cox Proportional Hazards Regression, random forests, Bayesian Networks, and software to identify immune-related pathways to Public Health. ..
  4. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2013
    ..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..
  5. Immunologic dysfunction in biliary atresia
    Jorge A Bezerra; Fiscal Year: 2013
    ..These results will identify an array of targets for new therapies that block progression of disease, restore the biliary epithelium, and foster long-term survival of patients with biliary atresia. ..
  6. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  7. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..These studies should provide novel insights into differential gene regulation in macrophages under conditions that induce "M2d" activation. ..
  8. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  9. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..These studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  10. Oxidant signaling for airway remodeling and inflammation
    YUICHIRO JUSTIN SUZUKI; Fiscal Year: 2012
    ..In addition, the results will fundamentally advance the field of lung cell biology. (End of Abstract) ..
  11. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
    ....
  12. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
    ..Asthma is a major public health problem that affects tens of millions of Americans and this work will help to identify and assess several potential new targets for asthma treatment. ..
  13. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..Its cause is not well understood. Identification of genes that increase risk of psoriatic arthritis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  14. High-Grade Astrocytoma-specific Molecular Targeting
    Waldemar Debinski; Fiscal Year: 2013
    ..a plasma membrane receptor that is over- expressed in around 80% of patients with GBM and not normal brain, interleukin 13 receptor alpha 2 (IL- 13Ra2)...
  15. LINKAGE ANALYSIS OF FAMILIAL PSORIASIS
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  16. Molecular Combinatorial Therapy of Glioblastoma Multiforme
    Waldemar Debinski; Fiscal Year: 2013
    ..regard to target specificity, it was found that a vast majority of GBM patients over-express binding sites for interleukin 13 (IL-13), IL-13Ra2...
  17. A novel splice variant of interleukin-13 and its role in promoting EAE responses
    Michael K Shaw; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Interleukin 13 (IL-13) is a pleiotropic, anti-inflammatory cytokine produced mainly by activated Th2 T cells...
  18. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..Project 2: Interleukin 13 (IL-13) modulates airway fibroblast function in human asthma via increased expression of platelet-derived ..
  19. Eosinophilic Myocarditis
    Noel R Rose; Fiscal Year: 2013
    ....
  20. microRNAs in the airway epithelium
    Edwin J Ostrin; Fiscal Year: 2013
    ..This proposal will provide me with the tools and experience for future independent work as a research-oriented pulmonary physician-scientist. ..
  21. Using signatures of T-helper cell inflammation to phenotype human asthma
    NIRAV RATI BHAKTA; Fiscal Year: 2011
    ....
  22. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  23. Epigenomics of T cells and innate immune cells in human asthma
    Pandurangan Vijayanand; Fiscal Year: 2013
    ..They will have a broad impact on our understanding of asthma, and set an important precedent for investigating the role of epigenetic mechanisms in other immune-mediated disorders. ) ..
  24. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
    ..In the course of these experiments, substances released by lung cells that contribute to asthma will be identified, and ways to block them will be tested. This will assist us in developing new treatments for asthma. ..
  25. E2A/HEB TRANSCRIPTION FACTORS IN T CELL DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2013
    ..More importantly, knowledge gained about Id3-mediated regulation of IL13 effectors will provide new strategies for early detection and therapeutic intervention of autoimmune diseases in humans. ..
  26. Dysregulation of RGS2 Protein and Airway Hyperresponsiveness in Asthma
    Yaping Tu; Fiscal Year: 2013
    ..Finally, we will investigate if anti-miR-1271 restores [unreadable]2-agonist bronchoprotective effect and ameliorates IL-13-induced mouse AHR in vivo. ..
  27. Immunobiology of MINA53
    Mark Bix; Fiscal Year: 2010
    ....
  28. Neuron - glial communication and brain aging
    Paula C Bickford; Fiscal Year: 2013
    ..that underly changes in brain aging that make the brain more suceptible to disease is critical and can lead to new approacfies to reduce the incidence or severity of neurodegenerative diseases and declines in cognitive function with age..
  29. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2012
    ..These studies will provide better understanding of the role of IL-13 in the pathogenesis of AD and its relationship with the development of asthma and the cellular and molecular mechanisms underlying these related disorders. ..
  30. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott G Woodruff; Fiscal Year: 2012
    ..End of Abstract) ..
  31. Mechanisms of fibrosis and lymphatic dysfunction in post-surgical lymphedema
    BABAK MEHRARA MEHRARA; Fiscal Year: 2013
    ....
  32. Duox2 Modulation of Viral Infection in Airway Epithelium
    Richart W Harper; Fiscal Year: 2012
    ..These studies will potentially elucidate specific mechanisms that are impaired in asthmatic patients. ..
  33. Treatment of secondary injury after ischemic stroke through targeting microglia
    Jaroslaw A Aronowski; Fiscal Year: 2013
    ....
  34. Role of the IL-13 system in dopaminergic cell death
    Bruno Conti; Fiscal Year: 2013
    ..This hypothesis is based on our preliminary studies in mice which showed that interleukin 13 receptor alpha 1 chain (IL-13R[unreadable]1), is highly expressed in DA neurons in the SNc and that mice that ..
  35. Magnetic-vortex microdiscs for glioma therapy
    Maciej S Lesniak; Fiscal Year: 2013
    ..Specific Aim 3: Examine the mechanism of cytotoxicity of microparticles and dynamics of triggered cell death. ..
  36. Cellular and Molecular Mechanisms of Renal Fibrosis
    Yanlin Wang; Fiscal Year: 2013
    ..Results from our studies will provide a new understanding of the molecular and cellular bases of renal fibrosis and could lead to the development of novel therapeutic strategies for the treatment of chronic kidney disease. ..
  37. Epithelial IL4Ralpha Regulates Colon Tumor Progression
    Barbara Fingleton; Fiscal Year: 2013
    ..Ultimately, this will lead to better therapy options for patients with metastatic colon cancer. ..
  38. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2011
    ..abstract_text> ..
  39. Biomarkers of survival in glioma epidemiology
    John K Wiencke; Fiscal Year: 2013
    ..abstract_text> ..
  40. Molecular Requirements for Recombinant Cytotoxins Efficacy
    Waldemar Debinski; Fiscal Year: 2010
    A restricted receptor (R) for interleukin 13 (IL13) was found in a vast majority of high-grade gliomas (HGG) patients...
  41. IL13-responsive genes in goblet cell metaplasia in asthma
    Mary Rose; Fiscal Year: 2007
    ..This will contribute to the development of pharmacological agents to control GCH and mucus overproduction in patients with asthma and possibly other chronic airway diseases [unreadable] [unreadable] [unreadable]..
  42. Glioma Immunotherapy Usingengineered T-Cells
    Michael Jensen; Fiscal Year: 2006
    ..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
  43. IL-13 Fusion Cytotoxin as a Targeted Therapeutic for IIP
    Cory Hogaboam; Fiscal Year: 2006
    ..The proposed studies will critically evaluate a pathophysiologic paradigm in IIP that has not been thoroughly examined to date. ..
  44. MECHANISMS OF HUMAN AIRWAY MUCOUS CELL HYPERPLASIA
    Linda Martin; Fiscal Year: 2004
    ..Herein, we propose that interleukin 13 (IL-13) is a key regulatory molecule controlling development of mucous cell hyperplasia...
  45. Mechanisms of epithelial barrier dysfunction mediated by inflammatory cytokines
    Christopher Weber; Fiscal Year: 2009
    ....
  46. Gutless Adenovirus Mediated Targeted Therapeutics for Glioma
    Marianela Candolfi; Fiscal Year: 2009
    ..Thus, we hypothesize that the targeted glioma gene therapy approach proposed will elicit high therapeutic efficacy in the absence of adverse side effects. ..
  47. Development of an Adenoviral Vector with Chimeric Fiber for Malignant Glioma
    MACIEJ LESNIAK; Fiscal Year: 2009
    ....
  48. Gene Regulation by IL-4 and IL-13 in Airway Cells
    June Lee; Fiscal Year: 2004
    ..abstract_text> ..
  49. INTERLEUKIN 13 STIMULATION OF HUMAN MONOCYTES
    MARTHA CATHCART; Fiscal Year: 2002
    ..These studies will substantially enhance our understanding of the signaling mechanisms induced upon exposure of monocytes to IL-13 and may suggest specific and selective means for modulating this response. ..
  50. IL-4 AND RESISTANCE TO TOXOPLASMA GONDII
    Christopher Hunter; Fiscal Year: 2000
    ..The regulation of the immune system during a response to infection could lead to new therapeutic paradigms and/or approaches to treatment of many diseases as well as prove important in vaccine design. ..
  51. Genetic & epidemiologic cohort study of asthma & allergy
    Susan Ewart; Fiscal Year: 2009
    ..abstract_text> ..
  52. ENVIRONMENT AND EPIGENETIC CONTROL OF IMMUNE RESPONSES
    Mark Bix; Fiscal Year: 2004
    ..abstract_text> ..
  53. Targeted Delivery of r-AdV for Treatment of Glioblastoma
    Yibing Li; Fiscal Year: 2002
    ..The goal is to demonstrate the feasibility of our strategy to mediate specific adenoviral infection in a murine xenografted glioblastoma model. This technology may ultimately improve gene therapy. ..
  54. IL13 EFFECTS ON MURINE HIV1 GP120 T CELL RESPONSES
    Luis Montaner; Fiscal Year: 1999
    ....
  55. Molecular studies on the role of IL4 & IL13 in fibrosis
    Constantin Bona; Fiscal Year: 2008
    ..The effect of dominant-positive and dominant-negative constructs on collagen gene expression will be studied in the presence or absence of profibrogenic cytokines. ..
  56. Interleukin-13 in Experimental Asthma
    Marsha Wills Karp; Fiscal Year: 2008
    ..Integration of the studies performed should provide a comprehensive understanding of the unique role of IL-13 in experimental asthma. ..
  57. Transgenic Modeling of TGF-Beta in the Lung
    Jack Elias; Fiscal Year: 2007
    ..4. Characterize the relationship(s) between epithelial apoptosis and the inflammatory and remodeling features and permanence of the TGF-beta1 phenotype. ..
  58. TRANSGENIC MODELING OF TH1/TH2 RESPONSES IN ASTHMA
    Jack Elias; Fiscal Year: 2001
    ..Mice that overexpress IL-4 will be generated and evaluated. (3) Characterize the effects of Th1 or Th2 polarization on host response to aeroallergen. ..
  59. AMCase and BRP-39 in Th2 Inflammation and Asthma
    Jack Elias; Fiscal Year: 2008
    ..AIM II. Characterize the role(s) of AMCase in Th2 inflammation, physiologic dysregulation and remodeling. AIM III. Characterize the role(s) of BRP-39 in Th2 inflammation, physiologic dysregulation and remodeling. ..
  60. VEGF in Th2 Inflammation and Asthma
    Jack Elias; Fiscal Year: 2008
    ..Aim #4. Characterize the reversibility of the inflammatory, immune and remodeling effects of VEGF. ..
  61. TRANSGENIC MODELING OF COPD
    Jack Elias; Fiscal Year: 2003
    ....
  62. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ....
  63. Dendritic Cell Immunotherapy of Malignant Gliomas
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  64. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  65. TH2-MEDIATED INFLAMMATORY RESPONSES IN THE SKIN AND LUNG
    CHRISTINA HERRICK; Fiscal Year: 2002
    ..My goal is to continue basic science investigation of atopic skin disease as a junior faculty member in the Department of Dermatology at Yale School of Medicine. ..