interleukin 5

Summary

Summary: Factor promoting eosinophil differentiation and activation in hematopoiesis. It also triggers activated B-cells for a terminal differentiation into Ig-secreting cells.

Top Publications

  1. ncbi IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    Padraic G Fallon
    Immunomodulation Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Immunity 17:7-17. 2002
  2. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
  3. ncbi The role of eosinophils in host defense against helminth parasites
    Amy D Klion
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Allergy Clin Immunol 113:30-7. 2004
  4. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
  5. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
  6. pmc Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
    J M Spergel
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 103:1103-11. 1999
  7. ncbi High local interleukin 5 production in granuloma faciale (eosinophilicum): role of clonally expanded skin-specific CD4+ cells
    A Gauger
    Br J Dermatol 153:454-7. 2005
  8. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
  9. ncbi Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:6510-7. 1998
  10. pmc Inhibition of airway remodeling in IL-5-deficient mice
    Jae Youn Cho
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0635, USA
    J Clin Invest 113:551-60. 2004

Detail Information

Publications326 found, 100 shown here

  1. ncbi IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    Padraic G Fallon
    Immunomodulation Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Immunity 17:7-17. 2002
    ..These mice reveal distinct spatial, temporal, and hierarchical cytokine requirements in immune function...
  2. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
    ..These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease...
  3. ncbi The role of eosinophils in host defense against helminth parasites
    Amy D Klion
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Allergy Clin Immunol 113:30-7. 2004
    ..This article will provide an overview of our current knowledge about eosinophils and their role, both protective and pathogenetic, in parasitic helminth infections...
  4. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  5. ncbi Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    M Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 163:466-75. 1999
    ..These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD...
  6. pmc Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
    J M Spergel
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 103:1103-11. 1999
    ..These results suggest that both the TH2 cytokines IL-4 and IL-5 and the TH1 cytokine IFN-gamma play important roles in the inflammation and hypertrophy of the skin in AD...
  7. ncbi High local interleukin 5 production in granuloma faciale (eosinophilicum): role of clonally expanded skin-specific CD4+ cells
    A Gauger
    Br J Dermatol 153:454-7. 2005
  8. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  9. ncbi Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:6510-7. 1998
    ..These data suggest that Ox-40/Ox-40L interactions act after initial activation events to prolong clonal expansion and enhance effector cytokine secretion, and may be involved in promoting long-lived primary CD4 responses...
  10. pmc Inhibition of airway remodeling in IL-5-deficient mice
    Jae Youn Cho
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0635, USA
    J Clin Invest 113:551-60. 2004
    ..Increased airway epithelial expression of alphaVbeta6 integrin may contribute to the increased activation of latent TGF-beta. These results suggest an important role for IL-5, eosinophils, alphaVbeta6, and TGF-beta in airway remodeling...
  11. ncbi Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease
    Paul S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200 Australia
    Pharmacol Ther 94:253-64. 2002
    ..While promising, newer therapies face a gauntlet of developmental challenges, but offer the hope of reducing allergic diseases once again to minor public health concerns...
  12. pmc Interleukin-5 regulates genes involved in B-cell terminal maturation
    Keisuke Horikawa
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 118:497-508. 2006
    ..Taken together, preferential Aid and Blimp-1 expression plays a critical role in IL-5-induced immunoglobulin-secreting cell differentiation and micro to gamma 1 CSR in CD38-activated B cells...
  13. pmc Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
    Yong Geun Kwak
    Department of Pharmacology, Institute of Cardiovascular Research, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Chonju, South Korea
    J Clin Invest 111:1083-92. 2003
    ..Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype...
  14. pmc T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
    M Lohning
    Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 95:6930-5. 1998
    ..Administration of either a mAb against T1/ST2 or recombinant T1/ST2 fusion protein attenuates eosinophilic inflammation of the airways and suppresses IL-4 and IL-5 production in vivo following adoptive transfer of Th2 cells...
  15. pmc Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production
    A Tominaga
    Institute for Medical Immunology, Kumamoto University Medical School, Japan
    J Exp Med 173:429-37. 1991
    b>Interleukin 5 (IL-5) has been suggested to be involved in the growth and differentiation of B cells and eosinophils...
  16. pmc Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxocara canis
    L A Dent
    Departments of Microbiology and Immunology, University of Adelaide, Adelaide, South Australia
    Infect Immun 67:989-93. 1999
    ..These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils...
  17. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  18. ncbi Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
    M Yang
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Am J Respir Cell Mol Biol 25:522-30. 2001
    ..Furthermore, IL-13-induced AHR, eosinophilia, and mucus production are critically dependent on the IL-4Ralpha chain and STAT-6...
  19. pmc Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9
    Brigita Sitkauskiene
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    Respir Res 6:33. 2005
    ..We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment...
  20. ncbi Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies
    N A Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, AZ 85259, USA
    J Immunol 158:1332-44. 1997
    ..These pathologies parallel clinical observations of patients with a profound eosinophilia and imply that IL-5 effector functions during some inflammatory responses may be contingent upon peripheral lymphohemopoietic expression...
  21. pmc CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5
    Y Kikuchi
    Department of Immunology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 92:11814-8. 1995
    ..Analysis of the synergistic effects of various cytokines with CD38 ligation on B-cell activation revealed that interleukin 5 (IL-5) showed the most potent effect on B-cell proliferation, Blimp1 gene expression, and IgM production...
  22. ncbi Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Allergy Clin Immunol 111:1062-8. 2003
    ..On activation by cross-linking the high-affinity IgE receptor (FcepsilonRI), expression of TNF-alpha, IL-3, IL-5, and IL-13 is induced in human intestinal mast cells...
  23. ncbi Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6459-66. 2002
    ..These findings suggest that IL-5-activated eosinophils may lose mIL-5Ralpha and release sIL-5Ralpha in vivo, which may limit IL-5-dependent inflammatory events in diseases such as asthma...
  24. ncbi Interleukin 5 in the link between the innate and acquired immune response
    Kiyoshi Takatsu
    Department of Immunobiology and Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
    Adv Immunol 101:191-236. 2009
    ....
  25. ncbi Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice
    Hubert Louis
    Laboratory of Experimental Gastroenterology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Gastroenterology 122:2001-10. 2002
    ..Because activated NKT cells also produce IL-5, a critical cytokine for eosinophil maturation and function, the role of IL-5 was investigated in this model...
  26. ncbi Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma
    Lorna J Wood
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:883-9. 2002
    ....
  27. pmc Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
    A L Mui
    Department of Cell Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
    EMBO J 14:1166-75. 1995
    ..In IL-3-dependent hemopoietic cells, both forms of STAT5 are expressed and activated in response to IL-3...
  28. pmc Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively
    M Takagi
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Exp Med 181:889-99. 1995
    ..These results strongly suggest that the lineage specificity of IL-5 is mainly due to the restricted expression of IL-5R alpha...
  29. ncbi Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
    Giuliana Cassese
    Department for Humoral Immunology, Deutsches Rheumaforschungszentrum Berlin, Berlin, Germany
    J Immunol 171:1684-90. 2003
    ....
  30. ncbi [The role of interleukin 13 and interleukin 5 in asthma]
    Maria Magdalena Tomasiak-Łozowska
    Klinika Alergologii i Chorób Wewnetrznych Uniwersytetu Medycznego w Białymstoku
    Postepy Hig Med Dosw (Online) 64:146-55. 2010
    ..The results of these studies seem very interesting and induced the authors to discuss this issue...
  31. ncbi Allergen stimulates bone marrow CD34(+) cells to release IL-5 in vitro; a mechanism involved in eosinophilic inflammation?
    A K Johansson
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Sweden
    Allergy 59:1080-6. 2004
    ..Alum, a commonly used adjuvant, enhances the release of IL-5 and may thereby enhance eosinophilopoiesis...
  32. pmc Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia
    J Wang
    Immunology and Infection Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Invest 102:1132-41. 1998
    ..These findings also provide the rationale for developing strategies to target circulating IL-5 and/or its receptors in bone marrow to effectively control asthmatic airways eosinophilia...
  33. ncbi Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit
    J Tavernier
    Flanders Interuniversity Institute for Biotechnology and Department of Respiratory Diseases, University of Ghent, Belgium
    Blood 95:1600-7. 2000
    The receptor for interleukin 5 (IL-5) consists of a cytokine-specific alpha chain (IL-5Ralpha) and a signaling beta chain, which is shared with interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF)...
  34. pmc Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells
    L R Brunet
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 67:3014-8. 1999
    ..The absence of IL-5 failed to affect the induction of Th2 responses in naive mice. Peritoneal exudate cells recovered from egg-injected IL-5(-/-) or WT mice produced equivalent levels of IL-4 following restimulation with SEA or anti-CD3...
  35. ncbi Regulation of eosinophilopoiesis in a murine model of asthma
    Mary Beth Hogan
    Department of Pediatrics, West Virginia University School of Medicine, PO Box 9214, Morgantown, WV 26506, USA
    J Immunol 171:2644-51. 2003
    ..Differentiation of eosinophil progenitor cells and phenotypic eosinophilia is T cell dependent and does not occur in athymic nude mice exposed to intranasal allergen...
  36. ncbi Resistance to helminth infection: the case for interleukin-5-dependent mechanisms
    Rick M Maizels
    J Infect Dis 190:427-9. 2004
  37. ncbi Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 64:725-32. 2009
    ....
  38. pmc Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    Patrick Flood-Page
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Clin Invest 112:1029-36. 2003
    ..Therefore eosinophils may contribute to tissue remodeling processes in asthma by regulating the deposition of ECM proteins...
  39. ncbi Sensitive human interleukin 5 impedimetric sensor based on polypyrrole-pyrrolepropylic acid-gold nanocomposite
    Wei Chen
    School of Chemical and Biomedical Engineering and Center for Advanced Bionanosystems, Nanyang Technological University, Nanyang Avenue, Singapore 639798
    Anal Chem 80:8485-92. 2008
    ..As a model, a human interleukin 5 (IL-5) immunosensor, an important sensor for disease pathology study, clinic diagnosis, and pharmaceutical ..
  40. pmc Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter
    Stefan Klein-Hessling
    Department of Molecular Pathology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 283:31030-7. 2008
    ..These data demonstrate the functional importance of cyclic AMP signals for the interplay between GATA-3 and NFATc factors in the transcriptional control of lymphokine expression in Th2 effector cells...
  41. pmc Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue
    C Azuma
    Nucleic Acids Res 14:9149-58. 1986
    ..Human interleukin-5 synthesized by the direction of the cloned cDNA induced immunoglobulin synthesis in human B cells stimulated by Staphylococcus aureus mitogen...
  42. pmc Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
    J J Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    J Exp Med 185:2143-56. 1997
    ..These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals...
  43. ncbi A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
    J Tavernier
    Roche Research Gent, Belgium
    Cell 66:1175-84. 1991
    cDNA clones encoding two receptor proteins involved in the binding of human interleukin 5 (hIL5) have been isolated. A first class codes for an IL5-specific chain (hIL5R alpha)...
  44. pmc Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
    D B Corry
    Department of Medicine, University of California San Francisco 94143 0654, USA
    J Exp Med 183:109-17. 1996
    ..No role for IL-5 or eosinophils could be demonstrated...
  45. pmc Eosinophilia in transgenic mice expressing interleukin 5
    L A Dent
    National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Exp Med 172:1425-31. 1990
    Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells...
  46. ncbi T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans
    Joseph A Jackson
    School of Biology, Nottingham University, Nottingham, United Kingdom
    J Infect Dis 190:1804-11. 2004
    ..The apparent plasticity of age-specific cytokine response-worm abundance relationships between different populations is also discussed...
  47. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  48. ncbi Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
    Lars Volkmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Med Microbiol Immunol 192:23-31. 2003
    ..factor of 160 in full infection). In conclusion, IL-4 and IL-5 dependent effector pathways operate against different stages of filarial worms, and IL-5 has a greater impact on parasite containment than IL-4...
  49. ncbi Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6452-8. 2002
    ..These observations provide a potential explanation for the inability of anti-IL-5 therapy to suppress airway hyperresponsiveness to inhaled Ag, despite a reduction in eosinophil recruitment...
  50. ncbi Eosinophils express functional IL-13 in eosinophilic inflammatory diseases
    Peter Schmid-Grendelmeier
    Swiss Institute for Allergy and Asthma Research, Davos Platz, Switzerland
    J Immunol 169:1021-7. 2002
    ..In conclusion, human eosinophils are able to produce and release functional IL-13 in eosinophilic inflammatory responses...
  51. ncbi Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways
    Cory Ebeling
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    J Allergy Clin Immunol 115:623-30. 2005
    ..These proteinases can activate the proteinase-activated receptor (PAR)-2, which has been shown to be upregulated in the airways of patients with asthma...
  52. ncbi Different IL-5 and IFN-gamma production from peripheral blood T-cell subsets in atopic and nonatopic asthmatic children
    Ja Hyung Kim
    Division of Allergy and Pulmonolgy, Department of Pediatrics, College of Medicine, Ulsan University, Asan Medical Center, Seoul, Korea
    J Asthma 41:869-76. 2004
    ....
  53. ncbi Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability
    D J Hall
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Blood 98:2014-21. 2001
    ....
  54. ncbi Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
    T Kinashi
    Nature 324:70-3. 1986
    ..To elucidate the molecular properties of TRF we isolated cDNA encoding TRF from the 2.19 T-cell line and report here the structure and multiple activities of this lymphokine...
  55. ncbi Interleukin 9 promotes influx and local maturation of eosinophils
    J Louahed
    Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Inc, Plymouth Meeting, PA, USA
    Blood 97:1035-42. 2001
    ..These data suggest that IL-9 may promote and sustain eosinophilic inflammation via IL-5-driven eos maturation of precursors...
  56. ncbi Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A
    V Ann Stewart
    Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Vaccine 24:6483-92. 2006
    ..Pre-clinical studies are on-going to identify new RTS,S formulations with improved magnitude and duration of specific immunity...
  57. ncbi Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:860-7. 2004
    ..Our results confirm that IL-4 and IL-13, but not IL-5, are critical for the development of sustained airway hyperreactivity and airway remodeling after allergen exposure...
  58. ncbi Eosinophil-selective mediators in human strongyloidiasis
    A Mir
    Department of Medicine, University of Valencia, Spain
    Parasite Immunol 28:397-400. 2006
    ..This rise suggests that selective mediators of the eosinophil can have a role in immunity against S. stercoralis in human infection...
  59. ncbi Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes
    J Vekemans
    Medical Research Council Laboratories, The Gambia
    Eur J Immunol 31:1531-5. 2001
    ..This study demonstrates that the human neonatal immune response to BCG is not biased towards Th2 and is characterized by the predominant production of IFN-gamma by CD4+ T lymphocytes...
  60. ncbi The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production
    Byoung gon Moon
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 172:6020-9. 2004
    ..Our results illuminate the role of IL-5 in the homeostatic proliferation and survival of mature B-1 cells and in IgA production in the mucosal tissues...
  61. ncbi Human infection with Ascaris lumbricoides is associated with a polarized cytokine response
    P J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Infect Dis 182:1207-13. 2000
    ..05) and L3/L4 stage (P<.001) antigens. Analysis of these data indicates that A. lumbricoides infections in endemic regions are associated with a highly polarized type 2 cytokine response...
  62. ncbi Overexpression of CD11b on eosinophils in atopic dermatitis: downregulation by cyclosporin A and upregulation by interleukin 5
    H Yamada
    Department of Dermatology, School of Medicine, Kinki University, Osaka, Japan
    Int Arch Allergy Immunol 120:100-3. 1999
    ..Stimulation of eosinophils from patients with inactive AD by interleukin 5 upregulated the expression of CD11b on these cells...
  63. pmc Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil
    S M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Laboratorio de Imunologia, Belo Horizonte MG, Brazil
    Clin Exp Immunol 136:334-40. 2004
    ....
  64. pmc Proliferation and interleukin 5 production by CD8hi CD57+ T cells
    Lee K Chong
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Eur J Immunol 38:995-1000. 2008
    ..by a distinct cytokine profile late after activation that includes the unexpected release of high levels of interleukin 5. These data indicate that CD8hi CD57+ T cells should not be considered as "end-stage" effector T cells ..
  65. ncbi Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice
    M D Inman
    Asthma Research Group, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 21:473-9. 1999
    ..These findings support the use of this model to explore the mechanisms of increased eosinopoiesis observed in human asthma...
  66. ncbi Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils
    L Cohn
    Sections of Pulmonary and Critical Care Medicine and Immunobiology and Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 162:6178-83. 1999
    ..These studies show definitively that IL-5, eosinophils, or mast cells are not essential, but signaling through IL-4Ralpha is critically important in Th2 cell stimulation of mucus production...
  67. ncbi IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Federal Republic of Germany
    Immunity 4:15-24. 1996
    ..IL-5 deficiency did not affect the worm burden of infected mice, indicating that increased eosinophils do not play a significant role in the host defence in this parasite model...
  68. ncbi Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells
    Atsuko Itakura
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 140:8-16. 2006
    ..In this study, we investigated the role of interleukin (IL)-5, which has broad effects on both eosinophils and B-1 cells, in elicitation of CS...
  69. ncbi A critical role for Pin1 in allergic pulmonary eosinophilia in rats
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Allergy Clin Immunol 120:1082-8. 2007
    ..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF...
  70. pmc Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    J Infect Dis 196:1844-51. 2007
    ..These experiments demonstrate that eosinophils function as antigen-presenting cells for the induction of the primary and the expansion of the secondary Th2 immune responses to S. stercoralis in mice...
  71. pmc Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation
    L Yang
    Department of Internal Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Exp Med 188:1739-50. 1998
    ..The major defects in the p50(-/-) mice were the lack of production of the Th2 cytokine interleukin 5 and the chemokine eotaxin, which are crucial for proliferation and for differentiation and recruitment, ..
  72. pmc Spontaneous cytokine production in children according to biological characteristics and environmental exposures
    Camila Alexandrina Figueiredo
    Instituto de Ciências da Saúde, Universidade Federal de Bahia, Salvador, Brazil
    Environ Health Perspect 117:845-9. 2009
    ..Environmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma...
  73. ncbi Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice
    T Yoshida
    Department of Immunology, Faculty of Medicine, University of Tokyo, Japan
    Immunity 4:483-94. 1996
    ..These results indicate that IL-5-induced eosinophils serve as potent effector cells in the killing of Angiostrongylus cantonensis in mice...
  74. ncbi Effect of anti-mIL-9 antibody on the development of pulmonary inflammation and airway hyperresponsiveness in allergic mice
    T T Kung
    Department of Allergy, Schering Plough Research Institute, Kenilworth, New Jersey 07003, USA
    Am J Respir Cell Mol Biol 25:600-5. 2001
    ..A single dose of the antibody was ineffective on all measures. These results indicate that an antibody to mIL-9 inhibits the development of allergic pulmonary inflammation and AHR in mice...
  75. ncbi Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues
    T Hiroi
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 162:821-8. 1999
    ..Taken together, the findings suggest that the IL-5/IL-5R signaling pathway is critically important for the development of common mucosal immune system independent sIgA+ B-1 cell in mucosal effector tissues in vivo...
  76. ncbi A putative silencer element in the IL-5 gene recognized by Bcl6
    Masafumi Arima
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 169:829-36. 2002
    ..Furthermore, the IL5BS was required for Bcl6 to repress expression of the IL-5 cDNA. Thus, the IL5BS may act as a silencer element for Bcl6 to repress expression of the IL-5 gene...
  77. ncbi Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa
    Lars E French
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Am Acad Dermatol 49:1170-4. 2003
    ..production by the patient's peripheral blood mononuclear cells demonstrated strongly increased production of interleukin 5, the synthesis of which could be completely blocked by interferon (IFN)-alpha...
  78. pmc Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB
    Bettina Hartenstein
    Deutsches Krebsforschungszentrum Heidelberg, Department of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 21:6321-9. 2002
    ..This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice...
  79. ncbi IL-5-induced integrin adhesion of human eosinophils caused by ERK1/2-mediated activation of cPLA2
    Xiangdong Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Chicago, Illinois 60637, USA
    J Leukoc Biol 72:1046-53. 2002
    ..This phosphorylation results from activation of PI3K and protein tyrosine kinases. We also find that src-family tyrosine kinase, possibly Lyn, is the upstream kinase causing PI3K activation...
  80. ncbi Blockade of focal clustering and active conformation in beta 2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras
    Shigeharu Myou
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 169:2670-6. 2002
    ..We conclude that H-Ras-mediated activation of ERK is critical for beta(2)-integrin adhesion and that Ras-protein functions as the common regulator for cytokine-, chemokine-, and G-protein-coupled receptors in human eosinophils...
  81. ncbi Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection
    Fiona J Culley
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College Faculty of Medicine, London, GB
    Eur J Immunol 32:1376-85. 2002
    ..Primed cognate Th2 immunity does not increase local chemokine production, but does increase IL-5 production, which greatly enhances the availability of eosinophils for recruitment to the lung...
  82. ncbi IL-5-induced airway eosinophilia--the key to asthma?
    E Hamelmann
    Department of Pediatrics, University Hospital Charite, Berlin, Germany
    Immunol Rev 179:182-91. 2001
    ..A better understanding of the underlying mechanisms leading to asthma pathology may yield more specific immunological strategies for the treatment of this disease which is increasing worldwide...
  83. ncbi Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study
    Johan C Kips
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Crit Care Med 167:1655-9. 2003
    ..We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials...
  84. ncbi Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras
    Shigeharu Myou
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637 1470, USA
    J Immunol 171:4379-84. 2003
    ..We conclude that Ras mediates Th2 cytokine production, airway inflammation, and airway hyperresponsiveness in immune-sensitized mice...
  85. ncbi Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice
    Michael T Hopfenspirger
    Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    J Immunol 168:2516-22. 2002
    ..These data suggest that mycobacterial Ags (BCG>>M. vaccae) are effective in attenuating allergic airway inflammation and associated changes in pulmonary functions in an allergen-presensitized state...
  86. ncbi The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs from atopic asthmatic patients
    N Powell
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Allergy Clin Immunol 108:915-7. 2001
    ..The data are also compatible with the hypothesis that the newer immunomodulatory drugs mycophenolate mofetil and sirolimus exert similar effects, perhaps with a more favorable benefit/risk ratio...
  87. ncbi Cytokine responses to mitogen and Schistosoma haematobium antigens are different in children with distinct infection histories
    J T Scott
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Parasite Immunol 23:519-26. 2001
    ....
  88. ncbi Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells
    K Horikawa
    Department of Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:5018-26. 2001
    ..Stat5a and Stat5b are not redundant, but rather are at least partially distinctive in their function...
  89. ncbi HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
    A F Porto
    , Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Parasite Immunol 23:503-7. 2001
    ..Immunological responses such as these are important in the control of this helminthic infection...
  90. ncbi Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice
    D H Broide
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0635, USA
    Am J Respir Cell Mol Biol 24:304-11. 2001
    ..Overall, these studies demonstrate that TNF, released after allergen challenge, is important in the induction of endothelial cell adhesiveness, a prerequisite for recruitment of circulating eosinophils...
  91. ncbi Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation
    Jhagvaral Hasbold
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, NSW 2042, Australia
    Nat Immunol 5:55-63. 2004
    ..Stochastic division-linked regulation of heterogeneity challenges the conventional paradigms linking distinct phenotypes to unique combinations of signals and has the potential to simplify our concept of immune complexity considerably...
  92. pmc Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation
    T Brunner
    Institute of Clinical Immunology, Bern, Switzerland
    J Exp Med 177:605-11. 1993
    ....
  93. ncbi Differential regulation of interleukin 5-stimulated signaling pathways by dynamin
    Magdalena M Gorska
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 281:14429-39. 2006
    ..Thus, we have identified specific functions for dynamin in the IL-5 signaling pathway and demonstrated its role in receptor endocytosis and termination of the ERK1/2 signaling pathway...
  94. pmc Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells
    B G Moon
    Department of Immunology, Division of DNA Biology and Embryo Engineering, Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan
    Immunology 102:289-300. 2001
    ..Thus, this present approach offers new insights into the functions of the cytoplasmic subregions of IL-5Ralpha, in particular its carboxy-terminal region...
  95. pmc Interleukin-5 modulates interleukin-8 secretion in eosinophilic inflammation
    L H Faccioli
    Department of Parasitology, Microbiology and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Mediators Inflamm 7:41-7. 1998
    ..canis. Moreover, in addition to showing that IL-5 is fundamental for the induction of blood eosinophilia, the present results suggest that this cytokine may play a new biological role by acting as modulator of IL-8 secretion...
  96. ncbi A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5
    James M Murphy
    Division of Molecular Bioscience, John Curtin School of Medical Research and the Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Biol Chem 278:10572-7. 2003
    ..The novel ligand-receptor interface formed between domains 1 and 4 represents the first example of a class I cytokine receptor interface to be composed of two noncontiguous fibronectin III domains...
  97. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998
    ..Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases...
  98. ncbi A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
    S P Hogan
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
    J Immunol 161:1501-9. 1998
    ..These findings may provide an explanation for the dissociation of airways eosinophilia from the development of airways hyperreactivity observed in some cases of asthma and in animal models of this disease...
  99. pmc Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice
    X F Lei
    Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Invest 101:1342-53. 1998
    ..Together, these findings demonstrate the importance of the CD40-CD40L costimulatory pathway in the full expression of the inflammatory response in the airways...
  100. pmc A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5
    T Yasue
    Department of Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 Japan
    Proc Natl Acad Sci U S A 94:10307-12. 1997
    CD38 ligation on mouse B cells by CS/2, an anti-mouse CD38 mAb, induced proliferation, interleukin 5 (IL-5) receptor alpha chain expression, and tyrosine phosphorylation of Bruton tyrosine kinase (Btk) from wild-type, but not from X ..
  101. pmc Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness
    S Y Eum
    Unite de Pharmacologie Cellulaire, Unité Associée Institut Pasteur Institut National de la Santé et de la Recherche Médicale 285, Paris, France
    Proc Natl Acad Sci U S A 92:12290-4. 1995
    ..b>Interleukin 5 (IL-5) titers in serum and bronchoalveolar lavage fluid of BP2 mice were augmented by the antigenic ..

Research Grants62

  1. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  2. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2013
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  3. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ....
  4. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  5. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  6. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..abstract_text> ..
  7. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
    ....
  8. Anti IL5 and Churg Strauss Syndrome: a double blind, placebo controlled trial
    Michael E Wechsler; Fiscal Year: 2013
    ....
  9. Role of Spi-C in eosinophil development and functional responses
    PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2013
    ..This proposal will provide key information with clinical applications, especially given the eosinophil- targeted therapies that are currently under avid development. ..
  10. Eosinophilic Myocarditis
    Noel R Rose; Fiscal Year: 2013
    ....
  11. Epigenomics of T cells and innate immune cells in human asthma
    Pandurangan Vijayanand; Fiscal Year: 2013
    ..They will have a broad impact on our understanding of asthma, and set an important precedent for investigating the role of epigenetic mechanisms in other immune-mediated disorders. ) ..
  12. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
    ..In the course of these experiments, substances released by lung cells that contribute to asthma will be identified, and ways to block them will be tested. This will assist us in developing new treatments for asthma. ..
  13. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 2000
    ..The expression of this gene will be determined in antigen and virus models of airway inflammation in the presence or absence of glucocorticoids. ..
  14. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    ..e., dietary supplementation with inexpensive SCN-), that could be applied even in impoverished communities as well as against more common allergic diseases, such as asthma. ..
  15. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..We hypothesize that histamine, leukotrienes and interleukin 5 produced into the nose and the maxillary sinus will be important for the generation of the eosinophilic ..
  16. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999
    DESCRIPTION (from the application): Interleukin 5 (IL-5) has been shown to be an important component of the cytokine regulatory network that controls peripheral eosinophil numbers and their recruitment/survivability at sites of ..
  17. IMMUNE RESPONSE DURING ENTERIC INFLAMMATORY DISEASE
    Michael Wannemuehler; Fiscal Year: 1993
    ..T cells from control and infected mice will be analysed for the production of gamma interferon (IFN-g) or interleukin 5 (IL 5)...
  18. PINWORM: A SELF TOLERANCE AND AUTOIMMUNE DISEASE MODIFIE
    Kenneth Tung; Fiscal Year: 2001
    ..In summary, with this hypothesis-driven proposal, we will explore a common and natural infectious agent and its capacity to terminate self tolerance and provoke autoimmune disease in neonatal mice. ..
  19. ACTIVATED MUTANTS AS PROBES OF GM-CSF RECEPTOR FUNCTION
    RICHARD D ANDREA; Fiscal Year: 2003
    ..In addition, it is proposed that novel reagents (eg. monoclonal antibodies) can be generated which interact with critical regions of hbetac and can trigger signalling activity in the absence of cytokine. ..
  20. REGULATION OF THL RESPONSES IN PULMONARY SARCOIDOSIS
    DAVID MOLLER; Fiscal Year: 2000
    ..Thus, these studies may assist in the development of new therapies designed to halt the granulomatous and fibrotic responses that lead to end-stage pulmonary disease in sarcoidosis. ..
  21. IMMUNOSUPPRESSION BY AN INHIBITOR OF INTERLEUKIN 2
    MARTHA CATHCART; Fiscal Year: 1991
    ..These studies will greatly enhance our knowledge of what HSF is, how it mediates immunosuppression in vitro and will give us an indication of its potential as an immunotherapeutic agent in transplantation and autoimmunity...
  22. IL3,IL5, and GM-CSF Signaling and Asthma
    Christian Schindler; Fiscal Year: 2004
    ..Specifically we propose to: 1. Further characterize StIP1. 2. Functionally characterize the STAT four-bundle-helix. 3. Explore the role of Stat5 signal decay in primary leukocytes. ..
  23. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2000
    ....
  24. Stress and Immunity in Pediatric Asthma
    Jack Nassau; Fiscal Year: 2004
    ..Techniques of analysis of variance with repeated measures and multiple regression will be used. Results will further our knowledge of the relationships between stress and immunity in asthma. ..
  25. Regulation of Interleukin-5 Receptor Signaling
    MAGARITA MARTINEZ MOCZYGEMBA; Fiscal Year: 2003
    ..In addition, eosinophils from IL-5 transgenic mice will be isolated and analyzed for their ability to be further stimulated by GM-CSF or IL-3 in vitro. ..
  26. Structural Mechanism of IL5-Receptor Subunit Recruitment
    Irwin Chaiken; Fiscal Year: 2004
    ..provided by applicant): The objective of this continuation application is to elucidate the mechanism of human interleukin 5 receptor recognition at the molecular and structural levels...
  27. STRUCTURE BASED DESIGN OF NOVEL IL5 RECEPTOR ANTAGONISTS
    HENGYI ZHU; Fiscal Year: 1999
    ..the goal of phase 2 activities aimed at refinement of the initial leads into qualified pre-clinical candidates for IL-5 antagonism PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  28. INTERLEUKIN 5 RECEPTOR RECOGNITION, MIMETICS, ANTAGONISM
    Irwin Chaiken; Fiscal Year: 2004
    ..And it will yield antagonist strategies which could lead to molecular tools for therapeutic intervention in asthma and other allergic diseases. ..
  29. The Signal Transduction Mechanism of Interleukin-5
    Rafeul Alam; Fiscal Year: 2005
    ..Lyn and IRIP may represent excellent therapeutic targets for intervention in asthma and other allergic diseases. ..
  30. Proteasome Regulation of Interleukin-5 Receptor Endocytosis
    MAGARITA MARTINEZ MOCZYGEMBA; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. STRUCTURE BASED DESIGN OF NOVEL INTERLEUKIN-5 RECEPTOR
    HENGYI ZHU; Fiscal Year: 2002
    ..The long term goal of this project is to develop at least one non-peptide IL-5 receptor antagonist as a potential anti-asthmatic and anti-allergic agent. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  32. MODULATION OF IL-5 MEDIATED INFLAMMATION
    DAVID HUSTON; Fiscal Year: 2006
    ..abstract_text> ..
  33. ROG--A NOVEL PROTEIN THAT REGULATES TH2 CYTOKINES
    I cheng Ho; Fiscal Year: 2003
    ....
  34. MECHANISMS OF EOSINOPHIL ASSOCIATED INFLAMATION
    Gerald Gleich; Fiscal Year: 2000
    ....
  35. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  36. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  37. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  38. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  39. SIGNAL TRANSDUCTION IN SENSITIZED AIRWAY SMOOTH MUSCLE
    Michael Grunstein; Fiscal Year: 2002
    ....
  40. Virus-Induced Mechanics of Altered Airway Responsiveness
    Michael Grunstein; Fiscal Year: 2008
    ..It is anticipated that the findings from these proposed studies would yield important new insights into the mechanistic interplay between viral respiratory pathogens, atopy, and altered airway responsiveness. [unreadable] [unreadable]..
  41. Maturation of Non-Specific Airways Reactivity
    Michael Grunstein; Fiscal Year: 2007
    ....
  42. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
  43. THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMAB
    Gerald Gleich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  44. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  45. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2003
    ..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..
  46. Aging and Immunity Workshop
    Laura Haynes; Fiscal Year: 2004
    ..In this proposal, we are specifically requesting funds to cover the basic costs to allow five junior investigators to attend the workshop, with the goal of fostering the next generation of immunologists in this field. ..
  47. The influence of age on CD4 helper activity
    Laura Haynes; Fiscal Year: 2006
    ..abstract_text> ..
  48. Tissue-Specific Mechanisms of Allergic Inflammation
    Bruce Bochner; Fiscal Year: 2004
    ..We expect that the results of these studies will be of great relevance to human disease pathogenesis and the development of new therapeutics. ..
  49. Adhesion Molecule Biology in Allergic Cells
    Bruce Bochner; Fiscal Year: 2007
    ..abstract_text> ..
  50. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  51. Fluorescent activated cell sorter for UNTHSC
    Jerry Simecka; Fiscal Year: 2005
    ..Thus, the instrument will be of significant benefit for several NIH funded projects and enable continued progress to a wide range of questions being asked. ..
  52. New York University School of Medicine CTSA Planning Grant
    William Rom; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  53. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..This will be the first step in the development of novel antischistosome chemotherapies, which are essential for continued public health measures. ..
  54. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..These studies, carried out in non-transformed hPrMC and hMC, have potential implications for the control of hMC distribution and effector function in asthma. ..
  55. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  56. Mosquito Immunity to Alphaviruses
    Brian Foy; Fiscal Year: 2006
    ..3) Characterize the mechanisms that Culex tritaeniorhynchus mosquitoes use to clear Sindbis virus-infected midgut cells. [unreadable] [unreadable]..
  57. Transcellular Communication in Airway Inflammation and Airway Hyperresponsiveness
    ALAN RICHARD LEFF; Fiscal Year: 2010
    ..Data derived from these studies should elucidate a new endogenous mechanism of transcellular communication that initiates airway inflammation and AHR. ..
  58. Chemogenomics to Identify New Molecular Targets in PF
    William Henderson; Fiscal Year: 2006
    ..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
  59. Role of cockroach proteases in airway inflammation
    Kristen Page; Fiscal Year: 2009
    ..Finally, we will investigate the role of endogenous TNF alpha in the airways using a TNF alpha neutralizing antibody and TNF alpha knockout mice. ..
  60. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..