insulin like growth factor ii

Summary

Summary: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

Top Publications

  1. ncbi Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
  2. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
  3. ncbi Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    A C Bell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Nature 405:482-5. 2000
  4. ncbi Role of insulin-like growth factors in embryonic and postnatal growth
    J Baker
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 75:73-82. 1993
  5. ncbi CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    A T Hark
    Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nature 405:486-9. 2000
  6. ncbi Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    M M Lau
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:2953-63. 1994
  7. ncbi Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2
    Hengmi Cui
    Institute of Genetic Medicine and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 62:6442-6. 2002
  8. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
  9. ncbi An enhancer deletion affects both H19 and Igf2 expression
    P A Leighton
    Howard Hughes Medical Institute, Princeton University, New Jersey 08544, USA
    Genes Dev 9:2079-89. 1995
  10. ncbi A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    G Christofori
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0534
    Nature 369:414-8. 1994

Detail Information

Publications260 found, 100 shown here

  1. ncbi Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
    ..We propose that the Igf2 gene, and perhaps other imprinted genes, control both the placental supply of, and the genetic demand for, maternal nutrients to the mammalian fetus...
  2. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation...
  3. ncbi Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    A C Bell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Nature 405:482-5. 2000
    ..Our results reveal that DNA methylation can control gene expression by modulating enhancer access to the gene promoter through regulation of an enhancer boundary...
  4. ncbi Role of insulin-like growth factors in embryonic and postnatal growth
    J Baker
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 75:73-82. 1993
    ....
  5. ncbi CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    A T Hark
    Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nature 405:486-9. 2000
    ..Consistent with our model, CTCF binding is abolished by DNA methylation. This is the first example, to our knowledge, of a regulated chromatin boundary in vertebrates...
  6. ncbi Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    M M Lau
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:2953-63. 1994
    ..These results show that Igf2r is paternally imprinted and reveal that the receptor is crucial for regulating normal fetal growth, circulating levels of IGF2, and heart development...
  7. ncbi Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2
    Hengmi Cui
    Institute of Genetic Medicine and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 62:6442-6. 2002
    ....
  8. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
    ....
  9. ncbi An enhancer deletion affects both H19 and Igf2 expression
    P A Leighton
    Howard Hughes Medical Institute, Princeton University, New Jersey 08544, USA
    Genes Dev 9:2079-89. 1995
    ..A modest decline in Ins-2 RNA was observed in the yolk sac. In contrast Mash-2, which is expressed in spongiotrophoblast cells of the placenta, was unaffected by the enhancer deletion...
  10. ncbi A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    G Christofori
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0534
    Nature 369:414-8. 1994
    ..Several signals, in this case including an oncoprotein and a growth/survival factor, thus appear to be needed to elicit hyperproliferation...
  11. ncbi Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer
    Susan K Murphy
    Division of Gynecologic Oncology, Duke University Medical Center, Box 91012, Durham, NC 27708, USA
    Mol Cancer Res 4:283-92. 2006
    ..These data indicate that the epigenetic changes observed in these cancers at the imprint center may contribute to IGF2 overexpression in a novel mechanistic manner...
  12. pmc Programming placental nutrient transport capacity
    A L Fowden
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 572:5-15. 2006
    ....
  13. ncbi Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer
    Niels A Hammer
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Reproduction 130:203-12. 2005
    ..The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. Thus IMPs, and in particular IMP1, may be useful auxiliary markers of testicular neoplasia...
  14. ncbi Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  15. ncbi Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    Adele Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:889-93. 2004
    ..These interactions are epigenetically regulated and partition maternal and paternal chromatin into distinct loops. This generates a simple epigenetic switch for Igf2 through which it moves between an active and a silent chromatin domain...
  16. pmc Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta
    C P Sibley
    Academic Unit of Child Health, Medical School, University of Manchester, St Mary s Hospital, Manchester M13 OJH, United Kingdom
    Proc Natl Acad Sci U S A 101:8204-8. 2004
    ..This provides a mechanism for the role of imprinted genes in controlling placental nutrient supply and fetal growth. Altered placental Igf2 could be a cause of idiopathic intrauterine growth restriction in the human...
  17. pmc A transcriptional insulator at the imprinted H19/Igf2 locus
    C R Kaffer
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 USA
    Genes Dev 14:1908-19. 2000
    ..We also characterize the insulator in vitro and show that it is neither enhancer nor promoter specific...
  18. pmc Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
    Adele Murrell
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS ONE 3:e1849. 2008
    ..This DMR, known as DMR0, has been shown to be methylated on the silent maternal IGF2 allele presumably with a role in repression. The effect of IGF2 DMR0 methylation changes in the aetiology of BWS or SRS is unknown...
  19. ncbi Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes
    W Dean
    Laboratory of Developmental Genetics Programme, The Babraham Institute, Babraham Hall, Cambridge CB2 4AT, UK
    Development 125:2273-82. 1998
    ..Our study establishes a model for how early embryonic epigenetic alterations in imprinted genes persist to later developmental stages, and are associated with aberrant phenotypes...
  20. ncbi Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae
    Lin Guo
    Institute of Medical Sciences, University of Toronto, Toronto, Canada
    Dev Biol 320:79-91. 2008
    ..Of particular interest, we demonstrated also a decrease in IGF2 mRNA levels in all SGA placentae and showed that the decrease is, in most cases, independent of H19 regulation...
  21. ncbi A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer
    Veronica Vella
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    J Clin Endocrinol Metab 87:245-54. 2002
    ..A growth-promoting autocrine loop is activated, therefore, and may affect thyroid cancer biology...
  22. pmc A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression
    Nathalie Berteaux
    INSERM U908, Universite des Sciences et Technologies de Lille, Batiment SN3, 59655 Villeneuve d Ascq cedex, France
    Mol Cell Biol 28:6731-45. 2008
    ..Moreover, the transcript is stabilized in breast cancer cells and overexpressed in human breast tumors. Finally, knockdown experiments showed that, in humans, 91H, rather than affecting H19 expression, regulates IGF2 expression in trans...
  23. ncbi Parental imprinting of the mouse insulin-like growth factor II gene
    T M DeChiara
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Cell 64:849-59. 1991
    ..These results demonstrate that IGF-II is indispensable for normal embryonic growth and that the IGF-II gene is subject to tissue-specific parental imprinting...
  24. ncbi Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
    R Feil
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Development 120:2933-43. 1994
    ..Our results suggest that allelic methylation patterns in Igf2 and H19 arise early in embryogenesis and change progressively during development. Some of these developmental changes are apparently under tissue-specific control...
  25. pmc Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constância
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
    ..Thus, crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development...
  26. ncbi Mechanisms causing imprinting defects in familial Beckwith-Wiedemann syndrome with Wilms' tumour
    Angela Sparago
    Dipartimento di Scienze Ambientali, Seconda Universita di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Hum Mol Genet 16:254-64. 2007
    ..Finally, the IC1 microdeletions are associated with a high incidence of Wilms' tumour, making their molecular diagnosis particularly important for genetic counselling and tumour surveillance at follow-up...
  27. ncbi Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
    Jan R Brants
    Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology VIB, Herestraat 49, B 3000 Leuven, Belgium
    FEBS Lett 569:277-83. 2004
    ..Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis...
  28. ncbi Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Trends Genet 13:330-4. 1997
    ..In addition, the precise phenotypic spectrum of BWS might depend on which maternally expressed gene is mutated...
  29. ncbi Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells
    Baisong Liao
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:48716-24. 2004
    ..Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism that appears independent of its ability to serve as a c-myc mRNA masking protein...
  30. ncbi Disruption of imprinting caused by deletion of the H19 gene region in mice
    P A Leighton
    Howard Hughes Medical Institute, Princeton University, New Jersey 08544, USA
    Nature 375:34-9. 1995
    ..The somatic overgrowth of heterozygotes for the maternal deletion is attributed to a gain of function of insulin-like growth factor 2, rather than a loss of function of H19...
  31. ncbi Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK
    T McKinnon
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Clin Endocrinol Metab 86:3665-74. 2001
    ..These results, taken together, reveal that IGF-II stimulates extravillous trophoblast cell migration by signaling through IGF type 2 receptor, involving inhibitory G proteins and activating the MAPK pathway...
  32. ncbi Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway
    K W Brown
    Department of Pathology and Microbiology, School of Medical Sciences, Bristol, UK
    Hum Mol Genet 5:2027-32. 1996
    ..DNA methylation in IGF2 remained monoallelic, suggesting that the mutation in this family had uncoupled allele-specific methylation from expression...
  33. pmc ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
    Ellen Markljung
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Biol 7:e1000256. 2009
    ....
  34. ncbi Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation
    Shin Da Lee
    School of Physical Therapy, China Medical University, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 291:E306-14. 2006
    ..The increased cardiac IGF-II, IGF-IIR, caspase 9, and cellular apoptosis were also found in hypertensive rats with abdominal aorta ligation...
  35. ncbi Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk
    Atsushi Kaneda
    Division of Molecular Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 65:11236-40. 2005
    ....
  36. pmc Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor
    Dirk Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 102:4085-90. 2005
    ..Our results suggest that the combined effects of the H19/IGF2-imprinting center microdeletion and 11p15 chromosome duplication were necessary for manifestation of BWS...
  37. ncbi A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    T M DeChiara
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Nature 345:78-80. 1990
    ..The effect of the mutation was exerted during the embryonic period. These results provide the first direct evidence for a physiological role of IGF-II in embryonic growth...
  38. pmc CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
    Tao Li
    Medical Service, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Mol Cell Biol 28:6473-82. 2008
    ....
  39. ncbi Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro
    C O'Neill
    Human Reproduction Unit, Royal North Shore Hospital of Sydney, St Leonards, New South Wales, Australia
    Biol Reprod 56:229-37. 1997
    ..The use of IVF and low embryo concentrations in culture may provide a functional multiple ablation model that will help to define the range of GFs required for normal embryo development...
  40. ncbi Crosstalk between the insulin-like growth factors and estrogens in breast cancer
    D Yee
    Department of Medicine, University of Minnesota Cancer Center, Minneapolis 55455, USA
    J Mammary Gland Biol Neoplasia 5:107-15. 2000
    ..Taken together, these observations suggest that the two growth regulatory pathways are tightly linked and that a further understanding of the mechanism of this crosstalk could lead to new therapeutic strategies in breast cancer...
  41. ncbi Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting
    James Harper
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Cancer Res 66:1940-8. 2006
    ..This evidence shows the functional potency of allelic dosage of an epigenetically regulated gene in cancer and supports the application of an IGF-II ligand-specific therapeutic intervention in colorectal cancer...
  42. pmc Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice
    Ryan B Corcoran
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 68:8788-95. 2008
    ..Exogenous Igf2 protein promoted proliferation of MB precursor cells (GNP) and a MB cell line, PZp53(MED). Blocking igf2 signaling inhibited growth of PZp53(MED) cells, implicating igf2 as a potential clinical target...
  43. ncbi Cohesin mediates transcriptional insulation by CCCTC-binding factor
    Kerstin S Wendt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 451:796-801. 2008
    ..We propose that cohesin functions as a transcriptional insulator, and speculate that subtle deficiencies in this function contribute to 'cohesinopathies' such as Cornelia de Lange syndrome...
  44. ncbi Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development
    A Louvi
    Department of Genetics and Development, Columbia University, New York, New York, 10032, USA
    Dev Biol 189:33-48. 1997
    ..Therefore, these results provide genetic evidence that the growth-promoting function of IGF-II during mouse embryogenesis is mediated in part by signaling through the insulin receptor...
  45. ncbi Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice
    A B Hassan
    Department of Zoology, University of Oxford, United Kingdom
    Cancer Res 60:1070-6. 2000
    ..We conclude that IGF-II supply is a modifier of intestinal adenoma growth, and we provide genetic evidence for its functional role in colorectal cancer progression...
  46. ncbi Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males
    T R Gaunt
    Human Genetics Research Division, University of Southampton School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Hum Mol Genet 10:1491-501. 2001
    ..The total proportion of BMI variance explained by this model was 2.25%, strongly suggesting that IGF2 genetic variation is a significant determinant of body weight in middle-aged males...
  47. ncbi In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A
    Laura Sciacca
    Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Oncogene 21:8240-50. 2002
    ..In SKUT-1 leiomyoma cells this fetal IR isoform may vicariate the IGF-IR for cell response to both insulin and IGF-II. Acting on the same IR-A receptor IGF-II is more potent than insulin in stimulating cancer cell migration...
  48. ncbi Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  49. ncbi IGFBP-6 five years on; not so 'forgotten'?
    Leon A Bach
    Department of Endocrinology and Diabetes, Alfred Hospital, Melbourne, VIC 3004, Australia
    Growth Horm IGF Res 15:185-92. 2005
    ..This is particularly significant since IGFBP-6 provides an attractive basis for therapy of IGF-II-dependent tumors...
  50. ncbi Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals
    V K Han
    Department of Paediatrics, Obstetrics and Gynaecology, Biochemistry and Anatomy, MRC Group in Fetal and Neonatal Health and Development, Lawson Research Institute, University of Western Ontario, London, Ontario, N6A 4V2, Canada
    Placenta 21:289-305. 2000
    ..Comparative studies will continue to be required to understand the functional role of IGFs and IGFBPs in each species...
  51. pmc Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
    K Ishihara
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Genome Res 10:664-71. 2000
    ..Our results demonstrate that comparative genomic sequencing is highly efficient in identifying regulatory elements...
  52. ncbi Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC)
    J G Scharf
    Department of Medicine, George August Universität, Gottingen, Germany
    Carcinogenesis 19:2121-8. 1998
    ..The present data point to the IGF axis as a complex regulatory system that self limits the mitogenic activity of exogenous IGFs...
  53. pmc Structure and functional analysis of the IGF-II/IGF2R interaction
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
    EMBO J 27:265-76. 2008
    ..Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site...
  54. ncbi High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not
    Haodong Xu
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 38:555-63. 2007
    ..Our findings of equivalent IGF-II expression in KOC-positive SCLC and LCNEC and KOC-negative carcinoid tumors suggest different regulatory mechanisms involved in the control of IGF-II expression in these tumors...
  55. ncbi Disruption of mesodermal enhancers for Igf2 in the minute mutant
    Karen Davies
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, UK
    Development 129:1657-68. 2002
    ..Our work shows that most known enhancers for Igf2 are located 3' of H19 and establishes an important genetic paradigm for the inheritance of complex regulatory mutations in imprinted gene clusters...
  56. ncbi Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch
    R A Drewell
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Development 127:3419-28. 2000
    ..The silencer is therefore part of a complex cis-regulatory region upstream of the H19 gene and acts specifically to ensure the repression of the paternal allele, without a predominant effect on the epigenetic switch in the germline...
  57. ncbi Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, leptin, and interleukin-6 with birth weight, birth length, and head circumference in term and preterm neonates
    Hui Chen Lo
    Department of Medical Education and Research, Changhua Christian Hospital, 135 Nanhsia Street, Changhua 500, Taiwan, Republic of China
    Nutrition 18:604-8. 2002
    ..Fetal growth process is governed by multiple factors. We investigated the relation of insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), leptin, and interleukin-6 (IL-6) with intrauterine growth in preterm and term neonates...
  58. ncbi Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth
    K Kaku
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba, Japan
    Acta Paediatr 96:363-7. 2007
    ..The aim of this study was to investigate the associations between the neonatal birth weight and the genotypes of polymorphic loci in the IGF2 and IGF2 receptor (IGF2R) genes...
  59. ncbi Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers
    Seiji Nakano
    Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683 8503, Japan
    Cancer Sci 97:1147-54. 2006
    ..Therefore, these findings suggest that LOI of LIT1 via epigenetic disruption plays an important role in colorectal carcinogenesis, but it is not necessarily associated with CDKN1C expression...
  60. ncbi Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma
    Andrea Zatkova
    Institut für Medizinische Biologie, Universitat Wien, Vienna, Austria
    Genes Chromosomes Cancer 39:126-37. 2004
    ....
  61. ncbi Epigenetic differences between Wilms' tumours in white and east-Asian children
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 363:446-51. 2004
    ..We investigated whether the difference in incidence of Wilms' tumour between children of east-Asian descent and white children is due to variations in proportion of tumours with loss of IGF2 imprinting (IGF2 LOI)...
  62. pmc Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
    J L Thorvaldsen
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
    Genes Dev 12:3693-702. 1998
    ..Thus, the H19 differentially methylated sequences are required for both H19 and Igf2 imprinting...
  63. ncbi Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity
    W H Wang
    Medical Service and GRECC, Veterans Affairs Palo Alto Health Care System and Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Biol Chem 271:27863-70. 1996
    ....
  64. pmc CTCF physically links cohesin to chromatin
    Eric D Rubio
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle WA 98195, USA
    Proc Natl Acad Sci U S A 105:8309-14. 2008
    ..These results have implications for the functional role of cohesin subunits in the pathogenesis of Cornelia de Lange syndrome and Roberts syndromes...
  65. ncbi Insulin-like growth factor II precursor gene organization in relation to insulin gene family
    T J Dull
    Nature 310:777-81. 1984
    ..The organization of the IGF-II precursor gene is discussed in relation to that of other insulin gene family members...
  66. pmc Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion
    C M Buchanan
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem J 360:431-9. 2001
    ..These findings suggest that preptin is a physiological amplifier of glucose-mediated insulin secretion...
  67. ncbi Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection
    Shiori Maenaka
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University Faculty of Medicine, Kanazawa, Japan
    Oncol Rep 15:791-5. 2006
    ..These results suggest that LOI of IGF2 in colorectal carcinoma and LOI in the background mucosa play important roles in carcinogenesis...
  68. ncbi Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    Bastiaan T Heijmans
    Molecular Epidemiology Section, Leiden University Medical Centre, Leiden 2333 ZC, The Netherlands
    Hum Mol Genet 16:547-54. 2007
    ....
  69. ncbi Physical mapping of the IGF2 locus in the South American opossum Monodelphis domestica
    B R Lawton
    Department of Molecular and Cell Biology University of Connecticut, Storrs, CT 06269, USA
    Cytogenet Genome Res 116:130-1. 2007
    ..We have mapped the imprinted insulin-like growth factor II (IGF2) gene of M. domestica as a first step in understanding the regulatory mechanisms involved in genomic imprinting in this marsupial...
  70. ncbi Use of mutagenesis to probe IGF-binding protein structure/function relationships
    D R Clemmons
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7170, USA
    Endocr Rev 22:800-17. 2001
    ..These results have revealed that discrete regions of IGFBP sequence can mediate important and specific functional properties of these proteins...
  71. ncbi Serum levels of insulin-like growth factor binding protein-3 in benign and malignant breast disease
    I M Holdaway
    Department of Endocrinology, School of Medicine, Auckland University, New Zealand
    Aust N Z J Surg 69:495-500. 1999
    ..The present study investigates whether this pattern also occurs in neoplastic breast disease...
  72. pmc Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
    T Moore
    Department of Development and Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 94:12509-14. 1997
    ..Our results support the proposal that tandem repeats act to target methylation to imprinted genetic loci...
  73. ncbi Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR
    K Yun
    Laboratory of Oncology, Department of Pathology, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    J Pathol 187:518-22. 1999
    ..The result was that the exon-connection approach was more accurate, thereby highlighting a significant problem in imprinting analyses where genomic DNA contamination cannot be completely ruled out...
  74. ncbi Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site
    H Cui
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 61:4947-50. 2001
    ..However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT...
  75. ncbi IGF-II ameliorates the dystrophic phenotype and coordinately down-regulates programmed cell death
    J Smith
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Cell Death Differ 7:1109-18. 2000
    ..Targeting PCD in dystrophic muscles reduces both PCD and the classical features of dystrophic pathology in the mdx mouse suggesting that IGF-II is a strong candidate for therapeutic intervention in the dystrophinopathies...
  76. pmc Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2)
    K Tadokoro
    National Children s Medical Research Center, Tokyo, Japan
    Nucleic Acids Res 19:6967. 1991
  77. ncbi Altered imprinting, promoter usage, and expression of insulin-like growth factor-II gene in gestational trophoblastic diseases
    Sung Jo Kim
    Comprehensive Gynecologic Cancer Center, Pundang CHA General Hospital, Sungnam, Kyonggi Do, South Korea
    Gynecol Oncol 88:411-8. 2003
    ..We aimed to understand the involvement of imprinted genes in the pathogenesis of gestational trophoblastic diseases (GTD) such as hydatidiform mole (H-mole) and gestational trophoblastic tumors (GTT)...
  78. ncbi Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    Takashi Sakatani
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 307:1976-8. 2005
    ..A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk...
  79. ncbi Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions
    Ionel Sandovici
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Hum Mol Genet 12:1569-78. 2003
    ..However, temporal changes also occur in isolated cases, as well as within multiple individuals in the same family, indicating that environmental factors may also play a role...
  80. ncbi Determination of IGF-I, IGF-II, IGFBP-2, and IGFBP-3 levels in serum and plasma: comparisons using the Bland-Altman method
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 13:341-6. 2003
    ..These findings emphasize the need to standardize methods of collecting blood samples in future epidemiological studies and trials...
  81. ncbi CTCF maintains differential methylation at the Igf2/H19 locus
    Christopher J Schoenherr
    Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Nat Genet 33:66-9. 2003
    ..Conversely, maternal H19 expression is reduced, suggesting a positive role for CTCF in the transcription of that gene. This study constitutes the first in vivo demonstration of the multiple functions of CTCF in an ICR...
  82. pmc An intragenic methylated region in the imprinted Igf2 gene augments transcription
    A Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    EMBO Rep 2:1101-6. 2001
    ..These results reveal a novel mechanism of gene expression whereby intragenic methylation can increase levels of transcription...
  83. ncbi Association between insulin-like growth factor-2 and metastases after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: a prospective study
    B C Song
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, Korea
    Cancer 91:2386-93. 2001
    ..CONCLUSIONS: Increased plasma IGF-2 levels after TACE, which are common in patients with large-sized tumors and high serum AFP levels, appear to be associated with the occurrence of metastatic HCC after TACE...
  84. ncbi Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis
    E Cariani
    INSERM U75, C H U Necker, Paris, France
    J Hepatol 11:226-31. 1990
    ..This finding is consistent with IGF-II being a marker of liver cell differentiation. In addition, this growth factor might be involved in liver cancer progression by an autocrine and/or paracrine mechanism...
  85. ncbi Insulin-like growth factor axis during embryonic development
    G J Allan
    Hannah Research Institute, Ayr KA6 5HL, UK
    Reproduction 122:31-9. 2001
    ..This article reviews the work that has been carried out in this area in the context of current understanding of the IGF system...
  86. ncbi Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  87. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
  88. ncbi Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development
    Rocio M Rivera
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:1-14. 2008
    ..Additionally, our results serve as a cautionary tale for gene expression studies in which embryo transfer is used...
  89. pmc Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes
    J Eggenschwiler
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genes Dev 11:3128-42. 1997
    ....
  90. ncbi Superovulation alters the expression of imprinted genes in the midgestation mouse placenta
    Amanda L Fortier
    Department of Human Genetics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Hum Mol Genet 17:1653-65. 2008
    ..Our findings contribute to the evidence that mechanisms for maintaining imprinting are less robust in trophectoderm-derived tissues, and have clinical implications for the screening of patients following assisted reproduction...
  91. ncbi Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human
    D Monk
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 15:1259-69. 2006
    ..The finding of additional transcripts within this locus will have important implications for IGF2 regulation in both cancer and metabolism...
  92. ncbi CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus
    Nora Engel
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 15:2945-54. 2006
    ....
  93. ncbi Nutrition, insulin, insulin-like growth factors and cancer
    E Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Horm Metab Res 35:694-704. 2003
    ..Further study is required to test these conclusions...
  94. ncbi Insulin-like growth factor II (IGF-II)
    S D O'Dell
    Wessex Human Genetics Institute, Southampton University Hospitals NHS Trust, UK
    Int J Biochem Cell Biol 30:767-71. 1998
    ..In the general adult population, the IGF2-INS gene cluster may also influence body weight, in which case IGF-II function could become a target for therapeutic intervention in obesity...
  95. ncbi Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element
    M A Ripoche
    Institut Cochin de Génétique Moléculaire ICGM, Institut National dela Santé et de la Recherche Médicale INSERM U257, Paris, France
    Genes Dev 11:1596-604. 1997
    ..Taken together with the results of a larger H19 mutation described previously, this indicates that an imprinting control element is located within the region 10 kb upstream of H19...
  96. ncbi Imprinting of Igf2 and H19 from a 130 kb YAC transgene
    J F Ainscough
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, UK
    Development 124:3621-32. 1997
    ..In addition, in situ analysis of the Igf2-lacZ reporter indicates that additional mesoderm-specific enhancers are present within the YAC clone. No obvious phenotype was detected from the excess gene dosage of H19...
  97. ncbi Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
    M Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Babraham, Cambridge, UK
    Nat Genet 26:203-6. 2000
    ....
  98. ncbi The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Clin Cancer Res 12:1208-14. 2006
    ..To assess the role of IGF-II in cancer, we analyzed IGF-II expression in ovarian cancer and examined its association with disease characteristics and prognosis...
  99. ncbi Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
    J D Ravenel
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Natl Cancer Inst 93:1698-703. 2001
    ..Analysis of LOI could provide a valuable molecular tool for the classification of Wilms tumor...
  100. ncbi CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain
    Rosita Bergstrom
    Department of Development and Genetics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Cell Cycle 6:450-4. 2007
    ..Here we show that maternal, but not paternal inheritance of a mutated H19 imprinting control region, lacking functional CTCF binding sites, underlies a late to early switch in replication timing of the maternal H19/Igf2 domain...
  101. ncbi Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting
    M Weber
    Institut de Genetique Moleculaire, UMR 5535 CNRS Université Montpellier II, IFR 24, 1919, route de Mende, 34293 Cedex 5, Montpellier, France
    Mech Dev 101:133-41. 2001
    ..We discuss possible relations between Igf2 allelic methylation and expression during fetal development...

Research Grants62

  1. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..This renewal application targets optimization of adeno-associated virus (AAV) based therapies to treat respiratory neurons in Pompe disease. ..
  2. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  3. Rapamycin-induced Selective Apoptosis in Malignant Cells
    Peter J Houghton; Fiscal Year: 2012
    ..The studies have the potential to radically alter outcome for these children, and reduce the debilitating sequellae of high dose radiation and chemotherapy. ..
  4. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..Achievement of these aims will make it possible to translate the mechanistic discoveries to molecular targeted therapies for children with MB. ..
  5. Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs
    Margaret von Mehren; Fiscal Year: 2013
    ....
  6. Inhibition of IGF-1R: A Therapeutic Strategy for Colon Cancer Stem-like Cells
    Bhaumik B Patel; Fiscal Year: 2013
    ....
  7. STRUCTURAL ANALYSIS OF THE MANNOSE 6-PHOSPHATE RECEPTORS
    Nancy M Dahms; Fiscal Year: 2013
    ..These studies will also provide the structural basis for the design of improved therapeutics for the treatment of lysosomal storage disorders, and novel inhibitors of viral infection and growth factor activation. ..
  8. Gene Expression in Long-term Memory
    Cristina M Alberini; Fiscal Year: 2013
    ..Results from these studies should advance our knowledge of neural mechanisms that may be employed to achieve memory enhancement and to treat cognitive impairments. ..
  9. Expansion of hematopoietic stem cells by Angiopoietin-like 2
    Chengcheng Zhang; Fiscal Year: 2010
    ....
  10. Mechanism Underlying Memory Stabilization
    Cristina M Alberini; Fiscal Year: 2013
    ..contextual fear conditioning types of memory in rats, we have recently found that the growth factor insulin like growth factor II (IGF-II) acts as a potent memory enhancer when administered during the consolidation or ..
  11. Load-Driven Bone Lengthening
    Ping Zhang; Fiscal Year: 2010
    ..The proposed R03 project will contribute to examining a possibility of non-invasive physical therapy for treatment of patients with limb length discrepancy. ..
  12. BIOSYNTHETIC ACTIVITY OF THE CHOROID PLEXUS
    Joseph Herbert; Fiscal Year: 1993
    ..In all of the above, as in our previous work, classic molecular gentic techniques will be complemented by a strong emphasis on morphological techniques, including immunohistochemistry and in situ hybridization...
  13. INTEGRATIVE ANALYSIS OF CORONARY ADAPTATIONS TO ISCHEMIA
    WILLIAM CHILIAN; Fiscal Year: 2000
    ....
  14. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2002
    ..These studies will determine whether exogenous haptotactic factors promote cell recruitment and matrix synthesis to and within meniscal wounds in vitro. ..
  15. Cytokine Inhibition in Hepatocellular Carcinoma
    Jonathan Schwartz; Fiscal Year: 2005
    ....
  16. Effects of Albuterol on Muscle Protein Synthesis
    Charles Lambert; Fiscal Year: 2007
    ..of albuterol administration (16 mg/24h) on skeletal muscle protein synthesis (MPS) and the mRNAs for insulin like growth factor II, and Ca2+ dependent proteolysis using Real Time PCR as well as the phosphorylation status of P70 S6 ..
  17. CONTROL OF CELL GROWTH BY MITOGEN RECEPTORS
    JAMES PERDUE; Fiscal Year: 1980
    ..The binding of 125I-ILAs and 125I-insulin and the rate of incorporation of TdR were studied as functions of CEF plating density...
  18. GENE EFFECTS ON STRENGTH RESPONSES TO AGE AND EXERCISE
    Bernard Hurley; Fiscal Year: 2005
    ..Conversely, identifying persons who improve their strength and muscle mass the least with strength training would allow them to focus on interventions that might be more efficacious for them. ..
  19. IGF II AND CATHEPSIN D IN TUMOR GROWTH AND METASTASIS
    Daisy De Leon; Fiscal Year: 2000
    ..More comprehensive studies may then be warranted to assess whether additional benefit is gained from including specific forms of cathepsin D and IGF-II among the prognostic indicators for tumor cell metastasis. ..
  20. MECHANISM AND FUNCTION OF GENOMIC IMPRINTING
    Shirley Tilghman; Fiscal Year: 2002
    ..Finally the evolution of imprinting will be studied in the marsupial, Monodelphis, and in two strains of the wild mouse Peromyscus, where dramatic perturbations in growth are observed in reciprocal F1 hybrids. ..
  21. PHASE II CLINICAL TRAIL - AN EXPLORATORY STUDY TO IDENTI
    Karen Lu; Fiscal Year: 2000
    ..Loss of heterozygosity of mismatch repair genes A study size of 64 women, 32 women per arm, will give a 80% power to detect an increase or decrease in the value of a given biomarker, with an alpha of 0.05%. ..
  22. ROLE OF IGFS IN WILMS TUMOR DEVELOPMENT
    JAMES PERDUE; Fiscal Year: 1991
    ....
  23. Low birth weight & other risk factors for hepatoblastoma
    LOGAN SPECTOR; Fiscal Year: 2009
    ..We further hypothesize that endogenous determinants of the ability to activate and detoxify toxins are risk factors among children with both normal and low birth weight. ..
  24. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 2003
    ....
  25. Epidemiology of Loss of Imprinting in Colorectal Cancer
    Marcia Cruz Correa; Fiscal Year: 2005
    ..Analysis of the fundamental characteristics of LOI in the IGF-2 gene will enable the determination of whether LOI at this locus is a risk factor for the development of colorectal cancer. ..
  26. STRUCTURE/FUNCTION OF CONNECTIVE TISSUE GROWTH FACTOR
    Gary Grotendorst; Fiscal Year: 2004
    ....
  27. INSULIN-LIKE GROWTH FACTOR II BIOLOGIC ACTIONS
    SAMUEL CASELLA; Fiscal Year: 1990
    ..By examining the interaction of IGF-II with these tissues at the molecular level and by extending our observations of its actions in vitro, we hope to better understand the role of this growth factor in the human fetus...
  28. ETHANOL EFFECT ON CELL GROWTH
    Raphael Rubin; Fiscal Year: 1999
    ..The results will highlight the mechanisms by which ethanol interferes with the IGF system, and the consequent disruption of cell proliferation, and may provide a basis for more extensive studies of protective measures. ..
  29. MOLECULAR STUDIES OF GROWTH FACTORS DURING DEVELOPMENT
    John Pintar; Fiscal Year: 2000
    ....
  30. ANTIBODIES AND ANTIGENS IN HEPATOCELLULAR CARCINOMA
    ENG TAN; Fiscal Year: 2005
    ..Other studies are to determine the target genes(s) of SG2NA and potential protein binding partners. Elucidation of the properties and function of these proteins might contribute to understanding co-activating factors in carcinogenesis. ..
  31. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2004
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  32. Neuroprotective Drugs for Alzheimer's Disease
    TREVOR TWOSE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. ROLE OF IGF-11 IN NERVOUS SYSTEM DEVELOPMENT
    DOUGLAS ISHII; Fiscal Year: 1990
    ..These studies serve to bridge the gap between neurite growth and attempts to identify the second messenger of neuritogenic polypeptides. Mice will be employed in this study as a source of nerve growth factor...
  34. IGFS AND OLIGODENDROCYTE DEVELOPMENT
    MICHAEL RIVKIN; Fiscal Year: 1999
    ....
  35. MALIGNANT POTENTIAL OF THE COMPONENTS OF WILMS TUMORS
    ABBOTT GARVIN; Fiscal Year: 1993
    ..Completion of the studies proposed would provide a valuable model system for the study of human cancer...
  36. Maternal obesity, intrauterine gene expression and breast cancer
    KARIN MICHELS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. INSULIN LIKE GROWTH FACTOR II IN BREAST CANCER
    Kevin Cullen; Fiscal Year: 1999
    ..3. To determine loss of imprinting of IGF-II by allele specific in situ hybridization in breast tumor biopsies. 4. To examine the utility of IGF-II/M6P receptor fragments as antitumor agents in breast cancer. ..
  38. MICROSATELLITE INSTABILITY AND COLONIC NEOPLASIA IN IBD
    Amy Noffsinger; Fiscal Year: 2003
    ....
  39. DEVELOPMENT OF ITOMEXOL AS A NOVEL HEPATOMA THERAPY
    JIFAN HU; Fiscal Year: 2000
    ..Once the therapeutic effect of the drug is confirmed, it will provide a non-invasive, non-toxic treatment for hepatoma and will be soon accepted by the hepatoma market. ..
  40. Individual Predoctoral Dental Scientist Fellowship
    Megan Kibbey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Role of Fibroblasts and IGF-II in Breast Carcinogenesis
    Andra Frost; Fiscal Year: 2003
    ..and in vivo models to assess the effect of human fibroblasts and their cellular products, emphasizing insulin like growth factor II (IGF-II), on the growth of non-transformed and partially transformed ("pre-neoplastic") human breast ..
  42. OBESITY: ROLE OF NUTRITION, IGF-II AND INSULIN
    THOMAS LAUTERIO; Fiscal Year: 1993
    ..Further, the work on dietary obesity resistant animals could yield information which would allow for the screening of populations and the detection of individuals at high risk for obesity...
  43. NEGATIVE REGULATION OF IGF-11 BY THE IGF-11R IN CANCER
    Matthew Ellis; Fiscal Year: 2000
    ....
  44. STUDIES IN GROWTH REGULATION
    Frank Stockdale; Fiscal Year: 1980
    ..This effect is both on tritiated thymidine incorporation, cell number, and accumulation of DNA in cell culture. The effect is additive with insulin in normal epithelium and is synergistic in some physiological states. ..
  45. Function of Ectopic c-Myc in the Liver
    Linda Lee; Fiscal Year: 2006
    ..The results obtained from the experiments using this animal model will allow us to construct new paradigms about how c-Myc functions in vivo. ..
  46. Early Diagnosis of Cervical Cancer
    SUBBI MATHUR; Fiscal Year: 2003
    ..We believe that serum IGF-II test could compliment the Pap test to reduce deaths by cervical cancer. ..
  47. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  48. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  49. Epigenetic effects if endocrine disruptors in fetal germ cells
    PIROSKA E SZABO; Fiscal Year: 2010
    ....
  50. Inhibition of Androgen Receptor to treat Prostate Cancer
    Gayathri Devi; Fiscal Year: 2003
    ..Based on these data, future pharmacokinetic and toxicology animal studies will allow proceeding to human phase I testing in a timely and efficient manner. ..
  51. Antisense Morpholino Oligomers to Treat Retinopathy
    Gayathri Devi; Fiscal Year: 2003
    ..The primary goal of this grant is to identify the optimal antisense alphav PMO, dose and schedule that maximally decreases alpha V expression and inhibits retinopathy of prematurity. ..
  52. Genetically Modified Rhesus Monkeys
    Shoukhrat Mitalipov; Fiscal Year: 2006
    ..Such animals should provide a resource for the study of human neurogenetic diseases and serve as pre-clinical models for new experimental treatments including gene and stem cell based therapies. ..
  53. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  54. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  55. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  56. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  57. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2007
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. [unreadable] [unreadable]..
  58. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  59. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  61. IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    Pinchas Cohen; Fiscal Year: 2007
    ....