rantes

Summary

Summary: A chemokine that is a chemoattractant for eosinophils, monocytes, and lymphocytes. It is a potent and selective eosinophil chemotaxin that is stored in and released from platelets and activated T-cells.

Top Publications

  1. ncbi Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    Andreas Schober
    Department of Molecular Cardiovascular Research and Cardiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Circulation 106:1523-9. 2002
  2. ncbi Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor
    H K Kim
    Hematologic Malignancies Branch, Division of Special Cancers, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang, 411 764, Gyeonggi, South Korea
    Eur J Cancer 39:184-91. 2003
  3. ncbi Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1
    Jinhua Xiang
    Research Service and Department of Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, USA
    Lancet 363:2040-6. 2004
  4. ncbi The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity
    Elina Azenshtein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Res 62:1093-102. 2002
  5. ncbi Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior
    Taha Hirbod
    Center for Molecular Medicine, Infectious Diseases Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, Sweden
    J Acquir Immune Defic Syndr 43:137-43. 2006
  6. ncbi Low levels of RANTES are associated with mortality in children with cerebral malaria
    Chandy C John
    University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Infect Dis 194:837-45. 2006
  7. ncbi Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration
    Robert F Schwabe
    Columbia University College of Physicians and Surgeons, 630 West 168th St, PH8East, Rm 105J, New York, NY 10032 3784, USA
    Am J Physiol Gastrointest Liver Physiol 285:G949-58. 2003
  8. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
  9. ncbi Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells
    Shinichi Konno
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 26:594-601. 2002
  10. ncbi Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta
    Mee Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 90:297-308. 2004

Detail Information

Publications319 found, 100 shown here

  1. ncbi Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    Andreas Schober
    Department of Molecular Cardiovascular Research and Cardiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Circulation 106:1523-9. 2002
    ....
  2. ncbi Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor
    H K Kim
    Hematologic Malignancies Branch, Division of Special Cancers, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang, 411 764, Gyeonggi, South Korea
    Eur J Cancer 39:184-91. 2003
    ..plasma levels of platelet microparticles (PMP), vascular endothelial growth factor (VEGF), IL-6, and the chemokine RANTES in patients with gastric cancer (n=109) and in healthy controls (n=29)...
  3. ncbi Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1
    Jinhua Xiang
    Research Service and Department of Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, USA
    Lancet 363:2040-6. 2004
    ..Longer survival in HIV-positive individuals is associated with high serum concentrations of ligands for CCR5 (RANTES [regulated on activation, normal T-cell expressed and secreted] and macrophage inflammatory proteins [MIP] 1alpha ..
  4. ncbi The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity
    Elina Azenshtein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Res 62:1093-102. 2002
    ..We have identified recently the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES), a major monocyte chemoattractant expressed by breast tumor cells, as a potential contributor to breast cancer ..
  5. ncbi Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior
    Taha Hirbod
    Center for Molecular Medicine, Infectious Diseases Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Solna, Sweden
    J Acquir Immune Defic Syndr 43:137-43. 2006
    ....
  6. ncbi Low levels of RANTES are associated with mortality in children with cerebral malaria
    Chandy C John
    University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Infect Dis 194:837-45. 2006
    ..In children with cerebral malaria (CM), serum chemokine levels and associated morbidity and mortality have not been characterized...
  7. ncbi Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration
    Robert F Schwabe
    Columbia University College of Physicians and Surgeons, 630 West 168th St, PH8East, Rm 105J, New York, NY 10032 3784, USA
    Am J Physiol Gastrointest Liver Physiol 285:G949-58. 2003
    ..study was to characterize the role of regulated on activation, normal T-cell expressed, and presumably secreted (RANTES) in activated HSCs...
  8. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ..stimulates the secretion of interleukin (IL)-6 and regulated on activation, normal T cells expressed and secreted (RANTES) from airway smooth muscle (ASM) cells, with the induction of each molecule being differentially regulated (IL-6 ..
  9. ncbi Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells
    Shinichi Konno
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 26:594-601. 2002
    ..but not TNF-alpha, synergistically enhanced regulated on activation, normal T cells expressed and secreted (RANTES) mRNA expression and protein secretion induced by RV16 or RV49...
  10. ncbi Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta
    Mee Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 90:297-308. 2004
    In the CNS, astrocytes are significant sources of RANTES/CCL5 (regulated upon activation, normal T cell expressed and secreted), a CC-chemokine with important biological function...
  11. ncbi Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease
    Arantxa Apolinario
    Hepatology Unit, University Hospital Santa Cristina, Madrid, Spain
    Am J Gastroenterol 97:2861-70. 2002
    ..Although chemokines seem to be important in certain inflammatory disorders, little is known about the role of these proteins in chronic hepatitis C...
  12. pmc Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells
    Corinne Henriquet
    Institut National de la Santé et de la Recherche Médicale U454 IFR3, 34295 Montpellier Cedex 5, France
    Lung Cancer 56:167-74. 2007
    In lung adenocarcinoma, expression of Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES) is a predictor of survival while that of interleukin (IL)-8 is associated with a poor prognosis...
  13. pmc Mechanisms of disease: regulation of RANTES (CCL5) in renal disease
    Alan M Krensky
    Division of Immunology and Transplantation Biology in the Department of Pediatrics at Stanford University School of Medicine, Stanford, CA, USA
    Nat Clin Pract Nephrol 3:164-70. 2007
    ..b>RANTES (regulated upon activation, normal T cell expressed and secreted [also known as CCL5]) is a model chemokine of ..
  14. pmc The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source
    C Goulding
    Department of Clinical Medicine and Dublin Molecular Medicine Centre, Trinity Centre for Health Sciences, St James Hospital, Ireland
    Gut 54:1157-61. 2005
    ..The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals.
  15. ncbi Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis
    Ana Paula M P Marino
    Department of Immunology, IOC FIOCRUZ, Rio de Janeiro, Brazil
    Circulation 110:1443-9. 2004
    ..The augmented expression of CC chemokines, especially CCL5/RANTES and CCL3/MIP-1alpha, in the hearts of infected mice suggests a role for CC chemokines and their receptors in the ..
  16. pmc Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, No 160 Sec 3 Taichung Gang Road, Taichung 407, Taiwan
    J Virol 78:12107-19. 2004
    ..Since immune cell infiltration is prominent, we investigated the production of a responding chemoattractant, RANTES (regulated upon activation, normal T-cell expressed and secreted), in response to JEV infection of glial cells...
  17. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..we selected seven single-nucleotide polymorphisms (SNPs) out of the previously reported factors, namely, RANTES promoter -28G/-403A, RANTES In1...
  18. ncbi Suppression of RANTES in children with Plasmodium falciparum malaria
    Tom Were
    Department of Pathology, School of Health Sciences, Kenyatta University, Nairobi, Kenya
    Haematologica 91:1396-9. 2006
    ..immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found that RANTES is decreased during severe MA (p<0...
  19. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
    ..4 activate these pathways to induce IFN-alpha/beta, regulated on activation, normal T cell expressed and secreted (RANTES), and gamma interferon-inducible protein 10 (IP-10) expression independently of the adaptor protein myeloid ..
  20. ncbi Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender
    Mark Booth
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Immunol 172:1295-303. 2004
    ..for levels of nine cellular immune molecules (IL-3, IL-4, IL-5, IL-10, IL-13, TNF-alpha, IFN-gamma, IL-1beta, and RANTES) in the absence of in vitro Ag stimulation, and after stimulation with egg and worm Ags...
  21. ncbi Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers
    Shehzad M Iqbal
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Infect Dis 192:728-38. 2005
    ..The HIV-1-resistant CSWs had a 10-fold increase in RANTES expression, compared with the HIV-1-uninfected CSWs...
  22. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  23. ncbi Early application of Met-RANTES ameliorates chronic allograft nephropathy
    Erwei Song
    Department of Nephrology, University Hospital, Essen, Germany
    Kidney Int 61:676-85. 2002
    ..Chemokines such as RANTES (regulated upon activation, normal T cell expressed) are thought to be responsible for the recruitment and ..
  24. ncbi Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:24347-55. 2005
    ..b>RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member of the CC chemokine family of ..
  25. pmc Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism
    Wakana Iijima
    Division of Oral Diagnosis and Radiology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Pathol 163:261-8. 2003
    ..Furthermore, infiltrating T cells, particularly CD8(+) T cells, were positive for RANTES/CCL5 and IP-10/CXCL10, the ligands of CCR5 and CXCR3, respectively...
  26. ncbi Importance of serum IL-18 and RANTES as markers for breast carcinoma progression
    Soheir A L Eissa
    Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo
    J Egypt Natl Canc Inst 17:51-5. 2005
    ..b>RANTES (regulated upon activation normal T-cells expressed and secreted) is a member of the C-C chemokine family with ..
  27. ncbi Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 50:91-106. 2005
    ..monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6)...
  28. pmc Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells
    Ute Oltmanns
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Br J Pharmacol 139:1228-34. 2003
    ..in asthma by virtue of their capacity to produce several inflammatory mediators including IL-8, GM-CSF and RANTES. The intracellular signal pathway underlying the production of these cytokines in HASMC is not entirely elucidated...
  29. ncbi Met-RANTES reduces endothelial progenitor cell homing to activated (glomerular) endothelium in vitro and in vivo
    Maarten B Rookmaaker
    Dept of Vascular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Physiol Renal Physiol 293:F624-30. 2007
    The chemokine RANTES (regulated upon activation normal T-cell expressed and secreted) is involved in the formation of an inflammatory infiltrate during glomerulonephritis...
  30. ncbi Peritoneal macrophages induce RANTES (regulated on activation, normal T cell expressed and secreted) chemokine gene transcription in endometrial stromal cells
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 89:1397-401. 2004
    ..the influence of IL-1 beta and other macrophage-derived cytokines on the transcriptional activation of the human RANTES (regulated on activation, normal T cell expressed and secreted) gene...
  31. ncbi The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues
    Hiroaki Kabashima
    Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 20:70-7. 2002
    ..MCP-1), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, (IFN-gamma)-inducible protein-10 (IP-10) and RANTES-producing cells were found to be present in inflamed human gingival tissues...
  32. ncbi The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors
    Jeffrey P Shaw
    Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland
    Structure 12:2081-93. 2004
    ..We have determined the structure of the chemokine RANTES (regulated on activation normal T cell expressed) in the presence of heparin-derived disaccharide analogs by X-ray ..
  33. ncbi CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Immunol 170:5658-66. 2003
    The chemokine CC chemokine ligand (CCL)5/RANTES as well as its respective receptor CCR5 mediate leukocyte infiltration during inflammation and are up-regulated early during the course of glomerulonephritis (GN)...
  34. ncbi Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
    Rosanna Ramhorst
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, IDEHU, University of Buenos Aires, Argentina
    Am J Reprod Immunol 57:147-52. 2007
    Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction...
  35. ncbi Differential activation of NF-kappa B, AP-1, and C/EBP in endotoxin-tolerant rats: mechanisms for in vivo regulation of glomerular RANTES/CCL5 expression
    Johanna Pocock
    Department of Internal Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    J Immunol 170:6280-91. 2003
    ..model of renal inflammation in rats was used in which we have previously demonstrated that the chemokine RANTES/CCL5 is expressed and secreted in glomeruli...
  36. ncbi Storage of platelets in additive solutions: the effects of magnesium and potassium on the release of RANTES, beta-thromboglobulin, platelet factor 4 and interleukin-7, during storage
    A Shanwell
    Department of Transfusion Medicine, Huddinge University Hospital, Stockholm, Sweden
    Vox Sang 85:206-12. 2003
    ..Therefore, we investigated whether the addition of magnesium and potassium to platelets stored in a platelet additive solution (PAS) would affect the generation of cytokines during platelet storage...
  37. ncbi Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma
    E Rojas-Ramos
    Dept of Allergy and Clinical Immunology, National Institute of Lung Diseases, Mexico DF, Mexico
    Eur Respir J 22:310-6. 2003
    ..presence of the eosinophil-activating chemokines regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemotactic proteins (MCP)-3 and -4, and eotaxins-1 and -2 in the bronchoalveolar lavage (BAL) fluid ..
  38. ncbi Expression of the chemokines MCP-1/CCL2 and RANTES/CCL5 is differentially regulated by infiltrating inflammatory cells
    Uwe Haberstroh
    Division of Nephrology and Osteology, Department of Internal Medicine, University Hospital, Hamburg 20246, Germany
    Kidney Int 62:1264-76. 2002
    ..examined whether monocytes/macrophages play a role in the expression of the C-C chemokines MCP-1/CCL2 and RANTES/CCL5 in renal tissue in a lipopolysaccharide (LPS)-induced model of inflammation, where previously we have shown ..
  39. ncbi Induction of maternal tolerance to fetal alloantigens by RANTES production
    Rosanna Ramhorst
    Division of Immunogenetics and Gynecology, University of Buenos Aires, Buenos Aires, Argentina
    Am J Reprod Immunol 56:302-11. 2006
    Previous studies have demonstrated a requirement for RANTES (regulated on activated normal T-cell expressed, and secreted) at immune privileged sites; we have investigated the role of RANTES in the induction of maternal-fetal tolerance.
  40. ncbi RANTES gene polymorphisms predict all-cause and cardiac mortality in type 2 diabetes mellitus hemodialysis patients
    Carsten A Böger
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, D 93042 Regensburg, Germany
    Atherosclerosis 183:121-9. 2005
    ..Chemokines and their receptors are important in regulating leukocyte influx and activation in atherosclerosis, and functional polymorphisms in the respective genes are associated with cardiovascular disease risk...
  41. ncbi Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 N E Pacific Street, Seattle, WA 98195 8070, USA
    J Infect Dis 190:1055-8. 2004
    ..0%; P=.012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3'A, RANTES (regulated on activation, normally T cell-expressed and -secreted)-403A, and RANTES-28G polymorphisms were not ..
  42. ncbi IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling
    Christianne Bandeira-Melo
    Department of Medicine, Harvard Thorndike Laboratories, Charles A Dana Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 168:4756-63. 2002
    ..to affect their capacity to release leukotriene C(4) (LTC(4)) or their preformed stores of chemokines (eotaxin, RANTES) or Th1 (IL-12) or Th2 (IL-4) cytokines. IL-16 dose dependently (0...
  43. pmc TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells
    Takashi Ando
    Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Arthritis Res Ther 8:R146. 2006
    ..MC3T3-E1 cells expressed Fn14 and produced RANTES (regulated upon activation, healthy T cell expressed and secreted) upon TWEAK stimulation through PI3K-Akt, but ..
  44. pmc Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori
    Takahiko Kudo
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, 111D Rm 3A 320, Houston, TX 77030, USA
    Infect Immun 73:7602-12. 2005
    b>RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown...
  45. ncbi Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease
    Cecilia Huerta
    Genética Molecular IRSIN FRIAT, Hospital Central Asturias, Oviedo 33006, Spain
    Neurosci Lett 370:151-4. 2004
    ..We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the ..
  46. ncbi Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..In this study, we report that blocking a chemokine pathway in vivo with the CC chemokine antagonist Met-RANTES reduces the progression of atherosclerosis in a hypercholesterolemic mouse model...
  47. ncbi Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation
    Pedro Caballero-Campo
    Fundación Instituto Valenciano de Infertilidad para el Estudio de la Reproducción Humana FIVIER, Universidad de Valencia, Espana
    Mol Hum Reprod 8:375-84. 2002
    ..in-vivo immunolocalization and hormonal regulation of interleukin (IL)-8, monocyte chemotactic protein (MCP)-1 and RANTES (regulated upon activation normal T-cell expressed and secreted) in the human endometrium during hormone ..
  48. ncbi Enzyme immunoassay detection of platelet-derived microparticles and RANTES in acute coronary syndrome
    Shosaku Nomura
    The First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Thromb Haemost 89:506-12. 2003
    ..and compared levels of PDMPs and a C-C chemokine, regulated on activation normally T-cell express and secreted (RANTES), by ELISA...
  49. ncbi Vpr- and Nef-dependent induction of RANTES/CCL5 in microglial cells
    Qiusheng Si
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Virology 301:342-53. 2002
    ..In addition, activation of microglia correlates best with clinical dementia. Although the beta-chemokine RANTES/CCL5 is important in modulating HIV infection as well as cellular activation, no information is available ..
  50. ncbi The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Shipai, Taipei, Taiwan, ROC
    J Ethnopharmacol 107:205-10. 2006
    ..conditions likely to be associated with inflammation and viral infection, were screened for their effect on RANTES secretion by influenza A virus (H1N1)-infected human bronchial epithelial cells (A549)...
  51. pmc Amelioration of rat adjuvant-induced arthritis by Met-RANTES
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 52:1907-19. 2005
    ..Met-RANTES, an amino-terminal-modified methionylated form of RANTES (CCL5), antagonizes the binding of the chemokines RANTES ..
  52. ncbi Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans
    Ioannis Moissidis
    Allergy and Immunology Section, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Genet Med 7:406-10. 2005
    IL-13, RANTES (Regulated on Activation, Normal T cells Expressed and Secreted), and cysteinyl leukotrienes are asthma and atopy mediators...
  53. ncbi Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes
    A Zhernakova
    Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Immun 7:544-9. 2006
    b>RANTES (regulated on activation, normal T-cell expressed and secreted) is a T-helper type 1 (Th1) chemokine that promotes T-cell activation and proliferation...
  54. ncbi Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase
    Rampura T Venkatesha
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
    Mol Immunol 42:581-7. 2005
    ..chemoattractant protein 1 (MCP-1/CCL2) and regulated upon activation, normal T-cell expressed and secreted (RANTES/CCL5) production in LAD 2 mast cells...
  55. pmc Role of CCL5 (RANTES) in viral lung disease
    Fiona J Culley
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 80:8151-7. 2006
    CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics...
  56. ncbi CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts
    Xuefeng Yu
    Department of Biology, Washington University, St Louis, MO 63130, USA
    J Bone Miner Res 19:2065-77. 2004
    ..Cytokines induced OB release of such chemokines, which may therefore significantly contribute to inflammatory bone loss...
  57. ncbi Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4
    Mikael Juremalm
    Research Group on Mast Cell Biology, Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 297:480-5. 2002
    ..Of seven CCR1 and CCR4 agonists tested, only CCL5/RANTES act as an agonist inducing chemotaxis...
  58. ncbi Expression of a full-length hepatitis C virus cDNA up-regulates the expression of CC chemokines MCP-1 and RANTES
    Hui Meng Soo
    Collaborative Anti viral Research Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore
    Virology 303:253-77. 2002
    ..Expression of full-length HCV-S1 led to induction of the CC chemokines RANTES and MCP-1 at both the mRNA and the protein levels in HeLa, Huh7, and HepG2 cells...
  59. ncbi Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese
    X Y Zhao
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Eur J Immunogenet 31:179-83. 2004
    ..the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China...
  60. ncbi Respiratory syncytial virus-induced CCL5/RANTES contributes to exacerbation of allergic airway inflammation
    Alison E John
    Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
    Eur J Immunol 33:1677-85. 2003
    ..early RSV infection with later cockroach allergen (CRA) challenge, we examined the role of RSV-induced CCL5/RANTES production on allergic airway responses...
  61. ncbi Elevated serum RANTES levels in patients with ovarian cancer correlate with the extent of the disorder
    Sami Tsukishiro
    Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, 1 Kawasumi, Nagoya 467 8601, Japan
    Gynecol Oncol 102:542-5. 2006
    To assess the clinical relevance of serum regulated upon activation, normal T-cell expressed and secreted (RANTES) levels in distinguishing patients with ovarian cancers from those with benign ovarian cysts, we measured its concentration ..
  62. ncbi Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma
    Tetsuya Kawano
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Allergy Clin Immunol 112:369-74. 2003
    ..Nonetheless, the exact mechanism involved in the interaction between these 2 molecules has yet to be determined...
  63. ncbi RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR Bologna, Dipartimento di Medicina Interna e Gastroenterologia, University of Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Exp Gerontol 37:219-26. 2002
    ..to a group of young subjects, we evaluated the ability of monocytes, T lymphocytes and NK cells: (1) to produce RANTES and MIP-1alpha, either in basal conditions or after stimulation with, respectively, LPS, anti-CD3 MoAb and IL-2; (..
  64. ncbi Immunoregulatory role of ocular macrophages: the macrophages produce RANTES to suppress experimental autoimmune uveitis
    Koh Hei Sonoda
    Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 171:2652-9. 2003
    ..We found that only the macrophage-enriched cells from the eye produced RANTES, and thus proposed that macrophage-derived RANTES facilitated the ocular inflammations...
  65. ncbi Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Gen Virol 84:2491-5. 2003
    Chemokines regulate migration of leukocytes to sites of infection. In this work, we have shown that the chemokine RANTES/CCL5 is produced after herpes simplex virus (HSV) infection of macrophages and fibroblasts and provide data on the ..
  66. ncbi Gene polymorphisms in CCR5, CCR2, CX3CR1, SDF-1 and RANTES in exposed but uninfected partners of HIV-1 infected individuals in North India
    Pallikuth Suresh
    Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Clin Immunol 26:476-84. 2006
    ..There was no association between CCR5-Delta32, CCR2-64I, CX3CR1-280 M, CX3CR1-249I, SDF-3'A, RANTES-28G and RANTES-403A polymorphisms and susceptibility against HIV in our cohort of EU individuals...
  67. ncbi Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females
    Nuanjun Wichukchinda
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    AIDS 20:189-96. 2006
    To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais.
  68. ncbi Chemokines and inflammation in the nasal passages of infants with respiratory syncytial virus bronchiolitis
    Terry L Noah
    Department of Pediatrics and Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, 27599 7220, USA
    Clin Immunol 104:86-95. 2002
    ..RSV-positive illnesses were associated with increased epithelial shedding, increased RANTES/protein ratios, and increased IL-8/protein ratios in NLF compared to RSV-negative illnesses...
  69. ncbi Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 15:2868-81. 2004
    ..with reductions in the tubular expression of the chemokines macrophage chemoattractant protein-1 (MCP-1) and RANTES (regulated upon expression normal T cell expressed and secreted)...
  70. ncbi A dual role for tumor-derived chemokine RANTES (CCL5)
    Evan P Adler
    Department of Biology, Lafayette College, Easton, PA 18042, USA
    Immunol Lett 90:187-94. 2003
    To investigate the role of tumor-derived CCL5 (regulated upon activation, normal T cell expressed and secreted, RANTES) in tumor immunity we compared the T cell response to tumors derived from the 4T1 murine mammary carcinoma cell line ..
  71. ncbi Enhanced production of MMP-1, MMP-3, MMP-13, and RANTES by interaction of chondrocytes with autologous T cells
    Hiroshi Nakamura
    Institute of Medical Science, St Marianna University, Sugao, 216 8512 Kawasaki, Japan
    Rheumatol Int 26:984-90. 2006
    ..The production of MMP-1, MMP-3, MMP-13, and regulated on activation, normal T expressed and secreted (RANTES) was enhanced by direct co-culture compared to indirect co-culture using Transwell...
  72. ncbi Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Hepatology 40:327-34. 2004
    ..Recently, interacting gene polymorphisms of the chemokine RANTES have been shown to affect HIV disease progression...
  73. ncbi A kinetics and modeling study of RANTES(9-68) binding to heparin reveals a mechanism of cooperative oligomerization
    Romain R Vivès
    Institut de Biologie Structurale, CNRS CEA UJF, 41 Rue Horowitz, 38027 Grenoble Cedex 01, France
    Biochemistry 41:14779-89. 2002
    ..In the study presented here, we analyzed the binding of heparin to RANTES(9-68), a N-terminally truncated form of the CC-chemokine RANTES...
  74. ncbi Low plasma RANTES levels are an independent predictor of cardiac mortality in patients referred for coronary angiography
    Erdal Cavusoglu
    Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 1257, Brooklyn, NY 11203 2098, USA
    Arterioscler Thromb Vasc Biol 27:929-35. 2007
    Our objective was to evaluate the prognostic value of baseline plasma RANTES levels in patients with known or suspected coronary artery disease...
  75. ncbi Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes
    Long Jin
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1175-9. 2004
    ..growth factor-inducible 14 (Fn14), and produced regulated on activation, normal T expressed and secreted (RANTES) upon TWEAK stimulation in a concentration-dependent manner...
  76. ncbi Human detrusor smooth muscle cells release interleukin-6, interleukin-8, and RANTES in response to proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha
    Kirsten Bouchelouche
    Smooth Muscle Laboratory, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Urology 67:214-9. 2006
    ..of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on IL-8, IL-6, and RANTES (regulated on activation, normal T cell expressed and secreted) release by human detrusor smooth muscle cells (..
  77. ncbi Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine
    H Bartosik-Psujek
    Department of Neurology, Medical University, Lublin, Poland
    Acta Neurol Scand 109:390-2. 2004
    ..The aim of the study was to evaluate the effects of immunosuppressive therapy on production of two proinflammatory chemokines--interleukin-8 (IL-8) and RANTES (regulated on activation, normal T cell expressed and secreted).
  78. pmc Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES
    Cristina Pastore
    Department of Immunology, The Scripps Research Institute The Salk Institute for Biological Studies, La Jolla, California, USA
    Antimicrob Agents Chemother 47:509-17. 2003
    ..We have investigated the inhibitory mechanism of three N-terminally modified RANTES variants (AOP-, NNY-, and PSC-RANTES) with the MT-2 human T-cell line stably expressing either native or mutated ..
  79. ncbi Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES
    Y Jia
    West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, People s Republic of China
    Gene Ther 13:1351-9. 2006
    ..A recombinant immunotoxin, DT390-RANTES-SRalpha, was constructed in an eukaryotic cell expression plasmid consisting of regulated on activation normal T ..
  80. ncbi Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium
    Philipp von Hundelshausen
    Department of Molecular Cardiovascular Research, University Hospital Aachen, Germany
    Blood 105:924-30. 2005
    The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes...
  81. ncbi [RANTES expression in nasal polyps fibroblasts; spontaneously and after stimulation with lipopolisaccharides (LPS) and phytohemagglutinin (PHA)]
    Beata Rostkowska-Nadolska
    Klinika Otolaryngologii Akademii Medycznej we Wrocławiu
    Otolaryngol Pol 60:143-7. 2006
    ..b>RANTES is a eosinophil chemoattractant factor likely could play an important role in a chronic inflammatory response in ..
  82. ncbi Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells
    Alessandra Valerio
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia University School of Medicine, Viale Europa 11, 25123 Brescia, Italy
    J Neurosci Res 78:371-82. 2004
    ....
  83. pmc Monocyte-derived RANTES is intrinsically elevated in periodontal disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels
    S J Fokkema
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    Clin Exp Immunol 131:477-83. 2003
    ..Untreated periodontitis patients released 2 fold more RANTES (regulated on activation normal T cell expressed and secreted) (P = 0...
  84. ncbi Activation of macrophages by gliadin fragments: isolation and characterization of active peptide
    Ludmila Tuckova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Leukoc Biol 71:625-31. 2002
    ..Peptide B (FQQPQQQYPSSQ) elicited the highest TNF-alpha, IL-10, and RANTES secretion and increase in IFN-gamma-primed NO production by mouse macrophages...
  85. ncbi Negative association between circulating total homocysteine and proinflammatory chemokines MCP-1 and RANTES in prepubertal lean, but not in obese, children
    Emanuel V Economou
    2 Clinic for Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece
    J Cardiovasc Pharmacol 44:310-5. 2004
    ..among plasma total homocysteine (tHcy)-an independent risk factor for future atherosclerosis-and MCP-1 and RANTES, two circulating chemokines inducing leukocyte transendothelial migration (TEM), implicated in the initial stages ..
  86. ncbi Macrophages and lymphocytes differentially modulate the ability of RANTES to inhibit HIV-1 infection
    Eleanore Gross
    Immunology and Inflammation Center, North Shore LIJ Research Institute, New York, NY, USA
    J Leukoc Biol 74:781-90. 2003
    The beta-chemokines MIP-1alpha, MIP-1beta, and RANTES inhibit HIV-1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR5 receptors...
  87. ncbi Biologic activity of RANTES in apheresis PLT concentrates and its involvement in nonhemolytic transfusion reactions
    Shinobu Wakamoto
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Transfusion 43:1038-46. 2003
    b>RANTES, one of the PLT-derived biologic response modifiers, accumulates in PLT concentrates (PCs) during storage and may play a causative role in nonhemolytic transfusion reactions (NHTRs) after PC transfusion.
  88. ncbi Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification
    Silvio Danese
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 172:2011-5. 2004
    ..that CD40 ligand (CD40L)-positive T cells could bind to platelets, cause their activation, and trigger granular RANTES release, creating a T cell recruitment feedback loop...
  89. ncbi Molecular characterization of miniature porcine RANTES and its chemotactic effect on human mononuclear cells
    Jaeseok Yang
    Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Transplantation 82:1229-33. 2006
    To elucidate the potential role of porcine RANTES (Regulated upon Activation Normal T cells Expressed and Secreted) in xenograft rejection, we investigated its chemotactic activity for human mononuclear cells, as well as the effect of ..
  90. ncbi Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Brown University Medical School, Providence, RI 02903, USA
    Biochem Biophys Res Commun 330:27-33. 2005
    ..HGF exerted its action through suppression of RANTES expression in renal tubules...
  91. ncbi Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants
    Pak C Ng
    Department of Pediatrics, Center of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
    Clin Chem 52:1181-9. 2006
    ..We investigated the immunologic profiles of preterm infants with sepsis, using chemokine and cytokine measurements to predict the development of sepsis-induced DIC at the onset of infection...
  92. ncbi Human herpesvirus 6A decreases the susceptibility of macrophages to R5 variants of human immunodeficiency virus 1: possible role of RANTES and IL-8
    Eszter Csoma
    Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    Virus Res 121:161-8. 2006
    ..HHV-6A infection resulted in increased secretion of RANTES and IL-8...
  93. ncbi Histamine and tryptase modulate asthmatic airway smooth muscle GM-CSF and RANTES release
    J Chhabra
    Respiratory Research Group, Faculty of Pharmacy A15, University of Sydney, Sydney NSW 2006, Australia
    Eur Respir J 29:861-70. 2007
    ..whether histamine and tryptase modulate ASM cell granulocyte-macrophage colony-stimulating factor (GM-CSF) and RANTES (regulated on activation, normal T-cell expressed and secreted) release and also to examine which receptors are ..
  94. ncbi RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese
    C R Wang
    Section of Rheumatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Exp Rheumatol 23:379-84. 2005
    There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients.
  95. ncbi Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm
    Jamie S Colonnello
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Vasc Surg 38:138-46. 2003
    ....
  96. pmc Production and expression of Gro-alpha and RANTES by peripheral blood mononuclear cells isolated from patients with Kawasaki disease and measles
    Hee Sun Kim
    Department of Pediatrics and Microbiology, Yeungnam University School of Medicine, Daegu, Korea
    J Korean Med Sci 18:381-6. 2003
    We investigated whether the production and gene expression of Gro-alpha and RANTES in Kawasaki disease differ in measles...
  97. ncbi Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study
    Golo Ahlenstiel
    Medizinische Klinik u Poliklinik 1, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    World J Gastroenterol 11:7631-8. 2005
    Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection...
  98. ncbi Serum levels of IL-6 and its soluble receptor, TNF-alpha and chemokine RANTES in scorpion envenomed children: their relation to scorpion envenomation outcome
    Abdel Haleem A Abdel-Haleem
    Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
    Toxicon 47:437-44. 2006
    ..IL-6), soluble IL-6 receptor (sIL-6R), regulated upon activation normal T cells expressed and secreted (RANTES ) and tumour necrosis factor-alpha (TNF-alpha) were determined once for the controls and twice for the victims, ..
  99. ncbi Intrapulmonary targeting of RANTES/CCL5-responsive cells prevents chronic fungal asthma
    Jane M Schuh
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Eur J Immunol 33:3080-90. 2003
    Regulated upon activation in normal T cells, expressed, and secreted (RANTES)/CCL5 is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease...
  100. ncbi Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures
    Arnaldo Caruso
    Chair of Microbiology, University of Brescia, Brescia, Italy
    J Med Virol 70:451-8. 2003
    ..Regardless of endothelial cell origin, HHV6 infection induced de novo synthesis of the RANTES CC-chemokine...
  101. ncbi Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium
    Thomas Baltus
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
    Blood 102:1985-8. 2003
    ..The propensity of chemokines such as CC chemokine ligand 5 (CCL5)/RANTES (regulated on activation, normal T cell expressed and secreted) to bind to glycosaminoglycans and to form higher ..

Research Grants65

  1. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Cytokines CXCL10, CXCL11, IL-7, RANTES and BAFF are induced 337, 45, 128, 84 and 119 fold, respectively, in synchronously infected ECs by 24 hrs p.i...
  2. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1[unreadable], MIP-1[unreadable], MIP-2, RANTES, TNF-[unreadable], and VEGF...
  3. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..IFN? induces in M? and microglia natural ligands of the HIV coreceptor CCR5, such as MIP-1??? and RANTES, which inhibit HIV-1 infection...
  4. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..ecto domain of the CCR5 receptor, hR-421 binds and neutralizes al 3 CCR5-binding chemokine ligands (MIP-?, MIP-?, RANTES) and prevents their binding and activation of the CCR1, CCR3, and CCR5 membrane receptors...
  5. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..the level of antioxidant enzyme Superoxide Dismutase, and reduces pro-inflammatory factors TNF-alpha, MCP-1, and RANTES. Recently, we further identified the active component of AX-3...
  6. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..domain of the CCR5 receptor, hR-421 binds and neutralizes all 3 CCR5-binding ligands (chemokines MIP-?, MIP-?, RANTES) and prevents their binding and activation of CCR1, CCR3, and CCR5...
  7. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..nitric oxide (eNO), urinary 8-isoprostane, and nasal inflammatory cytokines (interleukin- 8/CXCL8, IP-10/CXCL10, RANTES/CCL5)...
  8. Novel Functions of S1P in Neuroinflammation
    TOMASZ K KORDULA; Fiscal Year: 2013
    ..via the activation of nuclear factor ?B, induction of several chemokines important for MS and EAE, such as RANTES and IP-10, requires the activation of an additional transcription factor, interferon regulatory factor-1 (IRF-1)...
  9. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..Importantly, RANTES/CCL5 and macrophage inflammatory protein (MIP-11)/CCL3 are the chemokines shown to activate CCR1 and CCR5 receptor ..
  10. Control of HIV drug resistance in older patients
    Alonso Heredia; Fiscal Year: 2010
    ..Successful proof of this hypothesis will suggest CCR5 internalization (i.e., using RANTES analogs) and inhibition of expression (i.e...
  11. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..that T cells are increased and the chemokine regulated on activation, normal T-cell expressed and secreted (RANTES) and its receptor, CCR5, along with monocyte chemoattractant protein-1 (MCP-1) and receptor CCR2, are upregulated ..
  12. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) within these tissues will be examined to determine the extent of NK cell trafficking to the site of active viral ..
  13. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ..marrow cells derived from Darc-knockout (Darc-KO) mice exhibit reduced binding to chemokines such as MCP-1 and RANTES;2) femurs isolated from Darc-KO mice showed reduced TRAP positive bone resorbing surface compared to control mice...
  14. TNF-like weak inducer of apoptosis (TWEAK) signaling in lupus nephritis
    Chaim Putterman; Fiscal Year: 2013
    ..Treatment of podocytes with TWEAK leads to increased expression of key pathogenic cytokines, including MCP-1, RANTES, VCAM-1, and IP-10...
  15. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..We find that bladder pathology requires expression of RANTES, a mast cell chemokine that is induced in the urothelium by tumor necrosis factor alpha (TNF)...
  16. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..of cytokines and neuropeptides related to epilepsy (cytokines {CCL2 [MCP-1], CCL3 [MIP-1a], CCL4 [MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-amyloid, cholecystokinin, ..
  17. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl A Nath; Fiscal Year: 2013
    ..As our findings in the AVF suggest that MCP-1 may exert its adverse effects via RANTES (CCL5), the role of CCL5 in AVF failure will be examined using CCL5-/- mice and a CCL5 inhibitor...
  18. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..constitutively secrete the N-terminally modified CV-N (P51G) and an effective CCR5- targeted entry inhibitor, C1C5-RANTES. The latter is an N-terminally modified RANTES that targets the major HIV co-receptor CCR5 with an increased ..
  19. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2013
    ..epithelial cells (damage-associated molecular patterns, or DAMPs) can induce the expression of IL-8, ICAM-1, and RANTES through TLR2 and TLR3-dependent signal transduction pathways in the absence of pathogenic stimulation...
  20. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..the coat glycoprotein gp120 of HIV, acting through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) ..
  21. Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2012
    ..cocaine on production and gene expression of pro-inflammatory cytokines, (TNF1 &IL-6), chemokines (MCP-1&RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, neurons, microglial cells), and whether :(..
  22. EPSTEIN BARR VIRUS LATENCY
    David A Thorley-Lawson; Fiscal Year: 2013
    ..2. To study the role of the chemokine CCL5 (RANTES) in mediating epithelial and NPC tumor cell migration, invasion and metastasis. 3...
  23. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry J Smith; Fiscal Year: 2011
    ..GD-lgG/IGF-1R interactions result in the synthesis of powerful T cell chemoattractants, IL-16 and RANTES. Patients with TAO also have more IGF-1R expressing fibroblast precursors (fibrocytes) in their blood...
  24. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
    ..DPPIV/cd26 (Aim 1/3B), which inactivates NPY- Y1R-mediated and monocytic chemoattractant activities of RANTES and SDF-1 (Aim 1B)...
  25. Methamphetamine and HIV interactions in the regulation of glial activation
    Maria Cecilia Garibaldi Marcondes; Fiscal Year: 2013
    ..cells is to change the balance of reactive oxygen species (ROS) and induce inflammatory markers, such as CCR5 and RANTES. These changes are believed to be dopamine-dependent, but we have observed that both ROS and CCR5 can be induced ..
  26. Genital Anaerobes, Inflammation and HIV Risk;Rakai
    LANCE BRADLEY PRICE; Fiscal Year: 2012
    ..multiplex sandwich ELISA (SearchLight, Aushon Biosystems, MA) for TNFa, IFN?, IL-1[unreadable], IL-8, IL-6, IL-12, RANTES, Monokine Induced by IFN? (MIG/CXCL9), Macrophage Chemotactic Protein (MCP1/CCL2), and Interferon Inducible ..
  27. Basic and Comparative Studies of CCR5 Inhibition to Prevent HIV Transmission
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2010
    ..We have been developing RANTES analogues that block OCRS and inhibit HIV replication at subnanomolar concentrations...
  28. AIDS-Restrictive Innate Immune Mechanisms
    William H Carr; Fiscal Year: 2011
    ..g., interferon-y, MIP-1a &(3, and RANTES) as well as by cell-killing assays...
  29. Interferon Regulatory Factors and Periodontal Disease
    Frank C Gibson; Fiscal Year: 2012
    ..IFN)-1, as well as the interferon-induced protein Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) has been detected in human PD tissues...
  30. Mechanisms of Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2013
    ..C virus on production and gene expression of pro-inflammatory cytokines (TNF1 &IL-6), chemokines (MCP-1 &RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, microglial cells) and examine (Aim #1b), ..
  31. Chemokine Modulation of Airway Vagal Sensory Nerves
    CARL ROBERT POTENZIERI; Fiscal Year: 2011
    ..during both allergic and viral airway disease, "regulated upon activation, normal T-cell expressed and secreted" (RANTES), also known as CC chemokine ligand-5 (CCL5), has on the excitability of bronchopulmonary C-fibers...
  32. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..e. CC chemokines MIP-1a, MIP-1[unreadable], and RANTES by the cells...
  33. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2010
    ..We have shown that plasmids encoding the flt3 ligand (FL), lymphotactin (LTN), RANTES and MCP-1 cDNA as well as unmethylated cytosine-guanine dinucleotides oligodeoxynucleotide (CpG ODN), when used as ..
  34. Alveolar type II cell innate immune response to influenza
    ROBERT JAMES MASON; Fiscal Year: 2013
    ..interferon response with a focus on IL-29 and the cytokine inflammatory response with a focus on CXCL10, CXCL11, RANTES, and IL-6...
  35. RANTES and Eotaxin: New players in PD progression
    Kalipada Pahan; Fiscal Year: 2013
    ..However, the mechanism behind disease progression is poorly understood. We hypothesize that RANTES and eotaxin could hold the key for driving disease progression and that targeting these two chemokines may be an ..
  36. Psoriatic regulatory T cell dysfunction
    Kevin D Cooper; Fiscal Year: 2013
    ..suppress in developed psoriatic lesions, have decreased numbers of CCR5+ Tregs, decreased chemotaxis to Rantes and Mip1a, decreased CD73, and increased IFI27 (ISG12)...
  37. Leukocyte Signaling in Virus-Induced Asthma Exacerbation
    David Hall; Fiscal Year: 2009
    ..involvement of key signaling events in RV-stimulated mediator production by the macrophage, specifically, MCP-1, RANTES and IFN-a...
  38. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ..MIP-1 RA will target the "shared" C-C chemokine MIP-1/RANTES receptor involved in lymphocyte/monocyte attraction...
  39. Evaluating self-protection of Th17 cells against HIV-1 by CCR5 Ligands Synthesis
    Yelina Alvarez; Fiscal Year: 2013
    ..We will also evaluate the capacity of Th17 cells to synthesize CCR5 ligands (MIP-1Beta, MIP-1alpha and RANTES), which are known to have potent anti-viral activity against CCR5-tropic isolates, the dominant viruses currently ..
  40. UTERINE BIOLOGY AND THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS
    Kevin Osteen; Fiscal Year: 2003
    ..Project II examines the regulations of RANTES, a potent inflammatory chemokine capable of activating immune cells and disrupting gene regulation at implant ..
  41. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2007
    ..Kit, FcsR1, Fc,yR1, ICAM-1, HLA-DR, DP,DQ, Toll-like receptor 2) activation of epithelial cells (release of IL-8, RANTES, soluble TNF receptor 1; upregulation of ICAM-1, HLA-DR,DP,DQ, TNF receptor 1), adhesion and degranulation of ..
  42. A Tool for Modeling the Structure-Activity of Chemokine Receptors and Other GPCRs
    BENJAMIN DORANZ; Fiscal Year: 2009
    ..CCR5 molecular interactions, including critical amino acids responsible for interacting with a chemokine (RANTES), two monoclonal antibodies (2D7 and 45523), HIV-1 Env (JRFL), and a small- molecule drug (TAK-779)...
  43. OXIDANT INDUCED BETA CHEMOKINES IN GRANULOMA FORMATION
    Jeffrey Warren; Fiscal Year: 2000
    ..Regulated upon Activation, Normal T-cell Expressed and presumably Secreted (RANTES), macrophage inflammatory protein 1alpha (MIP-1alpha), and MIP 1beta...
  44. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..In fact, human interleukin-8 (IL-8), IFN-gamma inducible protein - l0 (IP-l0), CXCR3 (the receptor for IP-10), RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted), and MCP-l/JE (monocyte chemotactic protein-1) ..
  45. TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUS
    NANCY RUDDLE; Fiscal Year: 2003
    ..Chemokines (RANTES, MCP-1, and IP-10) are induced in RIPLT islets. When RIPLT mice are crossed to RIPB7 mice, diabetes occurs...
  46. CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGES
    Michael Coffey; Fiscal Year: 2000
    ..Preliminary data from our laboratory suggest that the C-C chemokines, especially RANTES, reduce HIV replication in peripheral blood monocytes (PBM) and AM...
  47. CYTOKINE GENE EXPRESSION BY VIRUS IN GLIAL CELLS
    MOON SHIN; Fiscal Year: 2000
    ..by which neurotropic viruses induce cytokine and chemokine gene expression in glial cells by studying TNF and RANTES genes. Pro-inflammatory cytokine TNF is a potent effector in primary demyelination...
  48. CLINICAL/EXPERIMENTAL RADIATION RESEARCH
    Paul Okunieff; Fiscal Year: 2002
    ..chemoattractant proteins MCP-1, MCP-2, MCP-3, the macrophage inflammatory proteins MIP-1alpha, MIP-1beta, and RANTES--all of which have inflammatory activities...
  49. Chemokine antagonists in a murine model for scleroderma
    Anita Gilliam; Fiscal Year: 2003
    ..chemokines such as macrophage chemoattractant protein (MCP-1/JE), macrophage inhibitory protein (MIP-1alpha) and RANTES are upregulated in Scl GVHD before accumulation of inflammatory cells and skin thickening...
  50. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2003
    ..Chemokines play a dual role in down regulating viral replication and spread (MIP-1, MIP-l, and RANTES) and in upregulating inflammation through chemotaxis; the end result is chronic activation and neurodegeneration...
  51. PLATELET REGULATION OF MONOKINE SYNTHESIS
    ANDREW WEYRICH; Fiscal Year: 2000
    ..Initial results indicate that P-selectin and RANTES (Regulated upon Activation Normal T Cell Expressed presumed Secreted), two platelet-derived molecules, are ..
  52. VIRAL EXACERBATIONS OF ASTHMA
    Scherer Sanders; Fiscal Year: 2002
    ..test the hypothesis that virus induced production of the eosinophil chemotactic and activating cytokines, eotaxin, RANTES, and granulocyte-macrophage colony stimulating factor (GM-CSF) from infected epithelial cells plays a central role ..
  53. Allergic Condition Biomarkers and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2004
    ..Gene products of genetic polymorphisms found on the IL-4, IL-13, IL-4Ralpha, IL-13Ralpha1, HLA -DRB1, RANTES, and neuronal nitric oxide synthase (nNOS) play a role in both ACs and the brain...
  54. Opioid Binding to U51: A Human herpes Virus Protein
    Jean Bidlack; Fiscal Year: 2002
    ..HHV-6 U51 is a chemokine receptor, which binds the chemokine RANTES, and other beta chemokines, such as eotaxin, monocyte chemoattractant protein 1, 3, and 4...
  55. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2005
    ..a specific immunization protocol in which vaccination with combinations of DNA constructs encoding the chemokines RANTES, IL-8, or CTACK, and/or a novel B7DeltaC-domain costimulatory protein results in an enhanced antigen specific cell ..
  56. REGULATION OF CC CHEMOKINES IN HUMAN AIRWAY EPITHELIUM
    Cristiana Stellato; Fiscal Year: 2004
    ..airway epithelial cells are an important source of three major eosinophil-active chemokines, eotaxin, MCP-4, and RANTES, that glucocorticoids (GCs) inhibit production of these chemokines, and that both production and sensitivity to ..
  57. FURTHER STUDIES ON ANTI HIV 1 ACTIVITY OF INTERLEUKIN 16
    Paul Zhou; Fiscal Year: 2003
    ..We will generate retroviral gene constructs expressing IL-16 and methionine-modified RANTES or methionine-modified SDF-1beta...
  58. Chemokine Receptor Signaling in HIV Neuropathology
    Marcus Kaul; Fiscal Year: 2007
    ..underlying the neuroprotection against the toxicity of gpl20, SDF-1 and NMDA by beta-chemokines MIP-1beta and RANTES via CCR5 using mixed cerebrocortical cultures from rodents, including CCR5-deficient and wild-type mice, and human ..
  59. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..The goal of the proposed study is to determine whether the CC and CXC chemokines (MIP-1?, MIP-1?, RANTES, and SDF-1) protect against intrapartum and breastmilk HIV-1 transmission...
  60. HIV1 INHIBITORY PROTEINS FROM TRANSFORMED CD8+ CELLS
    Mary Klotman; Fiscal Year: 2002
    ..These factors include the beta-chemokines RANTES, MIP-1alpha and MIP-1beta as well as macrophage derived chemokine (MDC)...
  61. New SHIV R5 env's (based on all subtypes) for effective microbicide testing in ma
    Eric Arts; Fiscal Year: 2009
    ..First, we will determine if higher concentrations of cmpd167 or PSC- RANTES are required to inhibit the "pathogenic" subtype A, B, C, and D pools of HIV or SHIVs (as compared to the standard ..
  62. Mechanism of RANTES-mediated Astrocyte Activation
    Martin Dorf; Fiscal Year: 2007
    It is now established that stimulation of astrocytes with RANTES induces a storm of proinflammatory chemokines and cytokines...
  63. VIRUS INDUCED GENE EXPRESSION IN AIRWAY EPITHELIAL CELLS
    MICHAEL HOLTZMAN; Fiscal Year: 2002
    ..on new findings related to epithelial expression of a critical immune modulator, the beta-chemokine designated RANTES. In particular, studies of isolated human airway epithelial cells indicate that polarized secretion of RANTES is ..
  64. ANTIBODY FUSION PROTEINS FOR THE THERAPY OF CANCER
    Joseph Rosenblatt; Fiscal Year: 2002
    ..directed against tumor associated antigens, such as CEA or her2/neu, linked to sequences encoding the chemokine RANTES and/or to the extracellular domain of the B7.1 T-cell costimulatory ligand...
  65. STAT1-DEPENDENT TRANSCRIPTION IN AIRWAY EPITHELIAL CELLS
    Michael Walter; Fiscal Year: 2002
    ..they have found that epithelial cells express a functional set of immune-response genes (ICAM-1, IRF-1, TAP1, and RANTES) under the control of an interferon-gamma (IFN-,gamma) signal transduction pathway...