artificial membranes

Summary

Summary: Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.

Top Publications

  1. ncbi Super high flux hemofiltration: a new technique for cytokine removal
    S Uchino
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Melbourne, Victoria 3084, Australia
    Intensive Care Med 28:651-5. 2002
  2. ncbi Mesoporous membrane templated by a polymeric bicontinuous microemulsion
    Ning Zhou
    Department of Chemical Engineering and Materials Science and Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nano Lett 6:2354-7. 2006
  3. ncbi Fabrication and characterization of polysulfone-dicalcium silicate composite films
    Wei Cheng
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People s Republic of China
    J Biomater Appl 20:361-76. 2006
  4. ncbi Asymmetrically functional surface properties on biocompatible phospholipid polymer membrane for bioartificial kidney
    Hideto Ueda
    Department of Materials Engineering, School of Engineering, The University of Tokyo, 7 3 1, Hongo, Tokyo 113 8656, Japan
    J Biomed Mater Res A 77:19-27. 2006
  5. ncbi Interfacial reactivity of block copolymers: understanding the amphiphile-to-hydrophile transition
    Alessandro Napoli
    Institute for Biomedical Engineering and Department of Materials, University of Zurich and Swiss Federal Institute of Technology ETH Zurich, CH 8044 Zurich, Switzerland
    Langmuir 21:9149-53. 2005
  6. ncbi Harnessing janus nanoparticles to create controllable pores in membranes
    Alexander Alexeev
    George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    ACS Nano 2:1117-22. 2008
  7. ncbi Membrane-grafted hyaluronan films: a well-defined model system of glycoconjugate cell coats
    Ralf P Richter
    Department of New Materials and Biosystems, Max Planck Institute for Metals Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany
    J Am Chem Soc 129:5306-7. 2007
  8. ncbi A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine
    David E Beck
    Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, USA
    Dis Colon Rectum 46:1310-9. 2003
  9. ncbi Membrane separations in biotechnology
    R van Reis
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Opin Biotechnol 12:208-11. 2001
  10. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002

Detail Information

Publications243 found, 100 shown here

  1. ncbi Super high flux hemofiltration: a new technique for cytokine removal
    S Uchino
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Melbourne, Victoria 3084, Australia
    Intensive Care Med 28:651-5. 2002
    ..To test whether hemofiltration using a hemofilter with large pores (super high flux hemofiltration) achieves effective cytokine removal...
  2. ncbi Mesoporous membrane templated by a polymeric bicontinuous microemulsion
    Ning Zhou
    Department of Chemical Engineering and Materials Science and Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nano Lett 6:2354-7. 2006
    ..The protocol for the generation of nanopores is selective cross-linking of one domain with the subsequent removal of the other domain by solvent dissolution...
  3. ncbi Fabrication and characterization of polysulfone-dicalcium silicate composite films
    Wei Cheng
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People s Republic of China
    J Biomater Appl 20:361-76. 2006
    ....
  4. ncbi Asymmetrically functional surface properties on biocompatible phospholipid polymer membrane for bioartificial kidney
    Hideto Ueda
    Department of Materials Engineering, School of Engineering, The University of Tokyo, 7 3 1, Hongo, Tokyo 113 8656, Japan
    J Biomed Mater Res A 77:19-27. 2006
    ..Thus, it functioned well as a renal tubule. Therefore, because of both its hemocompatibility and cytocompatibility, we could conclude that the PSM membrane is useful for as a renal tubule device for a bioartificial kidney...
  5. ncbi Interfacial reactivity of block copolymers: understanding the amphiphile-to-hydrophile transition
    Alessandro Napoli
    Institute for Biomedical Engineering and Department of Materials, University of Zurich and Swiss Federal Institute of Technology ETH Zurich, CH 8044 Zurich, Switzerland
    Langmuir 21:9149-53. 2005
    ..Subtle differences in response to the applied surface pressure for the diblock compared to the triblock suggest an effect of the different chain mobility...
  6. ncbi Harnessing janus nanoparticles to create controllable pores in membranes
    Alexander Alexeev
    George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    ACS Nano 2:1117-22. 2008
    ..Thus, the findings provide guidelines for designing nanoparticle-bilayer assemblies for targeted delivery, where the pores open and the cargo is released only when the local environmental conditions reach a critical value...
  7. ncbi Membrane-grafted hyaluronan films: a well-defined model system of glycoconjugate cell coats
    Ralf P Richter
    Department of New Materials and Biosystems, Max Planck Institute for Metals Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany
    J Am Chem Soc 129:5306-7. 2007
  8. ncbi A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine
    David E Beck
    Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, USA
    Dis Colon Rectum 46:1310-9. 2003
    ....
  9. ncbi Membrane separations in biotechnology
    R van Reis
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Curr Opin Biotechnol 12:208-11. 2001
    ..These developments will allow membranes to play an important role in the evolution of the next generation of biotechnology processes...
  10. ncbi Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
    ..The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain...
  11. pmc Structure and fluctuations of charged phosphatidylserine bilayers in the absence of salt
    Horia I Petrache
    Laboratory of Physical and Structural Biology, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 86:1574-86. 2004
    ..Our comparisons between bilayers of PS and PC lipids with the same chains and the same temperature enable us to focus on the effects of these headgroups on bilayer properties...
  12. pmc Interaction between artificial membranes and enflurane, a general volatile anesthetic: DPPC-enflurane interaction
    Nathalie Hauet
    Equipe Physicochimie des Systèmes Polyphasés, UMR 8612, Universite Paris Sud, F 92296 Chatenay Malabry, France
    Biophys J 84:3123-37. 2003
    ..All the results taken together allowed to draw a pseudo-binary phase diagram of enflurane-dipalmitoylphosphatidylcholine in excess water...
  13. ncbi High-throughput lipophilicity measurement with immobilized artificial membranes
    Bernard Faller
    Novartis Institutes for BioMedical Research, WSJ 350 3 04, CH 4002 Basel, and GiMS mbH, Maulbeerstrasse 44, CH 4058 Basel
    J Med Chem 48:2571-6. 2005
    ....
  14. ncbi Permeabilization of biological and artificial membranes by a bacterial dirhamnolipid produced by Pseudomonas aeruginosa
    Marina Sanchez
    Department of Biochemistry and Molecular Biology A, Faculty of Veterinary, University of Murcia, E 30100 Murcia, Spain
    J Colloid Interface Sci 341:240-7. 2010
    ..The results are discussed within the frame of the biological actions of dirhamnolipid, and the possible future applications of this biosurfactant...
  15. ncbi Permeation of permanently positive charged molecules through artificial membranes--influence of physico-chemical properties
    Holger Fischer
    Pharmaceutical Research, Discovery Chemistry Molecular Properties, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    Eur J Pharm Sci 31:32-42. 2007
    ..This work provides evidence that permanently charged molecules can have high passive membrane permeabilities provided that the charge can be spread over several aromatic ring systems...
  16. pmc NMR structure of a viral peptide inserted in artificial membranes: a view on the early steps of the birnavirus entry process
    Marie Galloux
    Unite de Pharmacologie Chimique et Genetique, CNRS, UMR 8151, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, 4 avenue de l Observatoire, Paris F 75270 Cedex 06, France
    J Biol Chem 285:19409-21. 2010
    ..All these data lead to a model in which the two domains of pep46 interact with the membrane to form pores...
  17. ncbi Selective adhesion of endothelial cells to artificial membranes with a synthetic RGD-lipopeptide
    V Marchi Artzner
    , Biophysik, , Garching, Germany
    Chemistry 7:1095-101. 2001
    ..ArgGly-Asp-D-Phe-Lys, abbreviated as cyclo(-RGDfK-), lipopeptide has been synthesized and incorporated into artificial membranes such as giant vesicles with DOPC and solid-supported lipid bilayers...
  18. ncbi Feeding through artificial membranes reduces fecundity for females of the blood-feeding insect, Rhodnius prolixus
    R Gary Chiang
    Biology Department, Redeemer University College, Ancaster, ON, Canada
    Arch Insect Biochem Physiol 74:103-13. 2010
    ..ranging from the use of warm-blooded hosts, to the use of previously collected blood offered through artificial membranes. This study compared the fecundity in mated and unmated females fed rabbit blood directly from the shaved ..
  19. ncbi Studying cell-to-cell interactions: an easy method of tethering ligands on artificial membranes
    Sebastian J Fleire
    Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, London, UK
    Methods Mol Biol 462:145-54. 2009
    ..This allows us to study the interaction of HEL-specific B cells with the tethered antigen by a variety of microscopy techniques. We recently used this system to study the activation of B cells by membrane antigens...
  20. ncbi In vitro comparison of bioabsorbable and non-resorbable membranes in bone regeneration
    L Marinucci
    Department of Experimental Medicine and Biochemistry, University of Perugia, Italy
    J Periodontol 72:753-9. 2001
    ..CONCLUSIONS: These data suggest bioabsorbable membranes, particularly collagen and hyaluronic acid, may promote bone regeneration through their activity on osteoblasts...
  21. ncbi High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes
    F Wohnsland
    Novartis Pharma AG, WKL-122.P.33, CH-4002 Basel, Switzerland
    J Med Chem 44:923-30. 2001
    ..In addition, alkane/water partition coefficients can be derived from intrinsic membrane permeabilities, making this assay the first high-throughput method able to measure alkane/water log P in the microtiterplate format...
  22. ncbi A novel technique to apply a Seprafilm (hyaluronate-carboxymethylcellulose) barrier following laparoscopic surgeries
    Yi Chen Chuang
    Department of Obstetrics and Gynecology, E Da Hospital, Kaohsiung, Taiwan
    Fertil Steril 90:1959-63. 2008
    ..To describe a novel technique for application of a Seprafilm (modified hyaluronate-carboxymethylcellulose) barrier laparoscopically, and to assess the adequacy of coverage of desired sites...
  23. ncbi Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells
    Daniel Rothamel
    Department of Oral Surgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Oral Implants Res 15:443-9. 2004
    ..Within the limits of the present study, it was concluded that (i) BG, TD and OS promoted, and (ii) BM inhibited the attachment and proliferation of human PDL fibroblasts and human SaOs-2 osteoblasts...
  24. ncbi Transport across artificial membranes-an analytical perspective
    Andreas Janshoff
    Institut fur Physikalische Chemie, Johannes Gutenberg Universitat, Jakob Welder Weg 11, 55128 Mainz, Germany
    Anal Bioanal Chem 385:433-51. 2006
    ..However, channel forming proteins and transporters are more difficult to insert functionally and thus, there are yet only few examples that demonstrate the applicability of such systems as biosensor devices...
  25. ncbi Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier
    A Reichel
    Department of Physiology, Biomedical Sciences Division, King s College London, UK
    Pharm Res 15:1270-4. 1998
    ....
  26. ncbi Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability
    Masaaki Fujikawa
    Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Bioorg Med Chem 13:4721-32. 2005
    ....
  27. ncbi Dynamics of raft molecules in the cell and artificial membranes: approaches by pulse EPR spin labeling and single molecule optical microscopy
    Witold K Subczynski
    National Biomedical EPR Center, Biophysics Research Institute, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1610:231-43. 2003
    ..Finally, we propose a thermal Lego model for rafts as the basic building blocks for signaling pathways in the plasma membrane...
  28. ncbi ESR and monolayer study of the localization of coenzyme Q10 in artificial membranes
    M Grzybek
    Institute of Biochemistry and Molecular Biology, University of Wrocław, Przybyszewskiego 63, 51 148 Wrocław, Poland
    Gen Physiol Biophys 24:449-60. 2005
    ....
  29. ncbi Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 30:73-80. 2003
    ..The purpose of the present study was to compare clinically the treatment of deep intrabony defects with a combination of a bovine-derived xenograft (BDX) and a bioresorbable collagen membrane to access flap surgery...
  30. pmc Structure of gel phase DMPC determined by X-ray diffraction
    Stephanie Tristram-Nagle
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213 USA
    Biophys J 83:3324-35. 2002
    ..2 +/- 0.5 A(2)), the compressibility modulus (K(A) = 500 +/- 100 dyn/cm), various thicknesses, such as the hydrocarbon thickness (2D(C) = 30.3 +/- 0.2 A), and the head-to-head spacing (D(HH) = 40.1 +/- 0.1 A)...
  31. pmc Voltage-induced nonconductive pre-pores and metastable single pores in unmodified planar lipid bilayer
    K C Melikov
    A. N. Frumkin Institute of Electrochemistry, Russian Academy of Sciences, Moscow, 117071 Russia
    Biophys J 80:1829-36. 2001
    ..Similar pre-pore defects and metastable conductive pores might be involved in remodeling of cell membranes in different biologically relevant processes...
  32. pmc Biosensing using porous silicon double-layer interferometers: reflective interferometric Fourier transform spectroscopy
    Claudia Pacholski
    Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gillman Drive, La Jolla, California 92093 0358, USA
    J Am Chem Soc 127:11636-45. 2005
    ..Detection can be accomplished either by computing the weighted difference in the frequencies of two peaks or by computing the ratio of the intensities of two peaks in the FFT spectrum...
  33. ncbi The localization and photosensitization of modified chlorin photosensitizers in artificial membranes
    Shimshon Ben Dror
    Department of Physics and Nano Medicine Research Center, Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, 52900, Israel
    Photochem Photobiol Sci 8:354-61. 2009
    ..we investigate the localization and photophysical properties of twelve synthetically derived chlorins in artificial membranes, with the goal of designing more effective photosensitizers for photodynamic therapy (PDT)...
  34. ncbi Electron cryo-microscopy reveals mechanism of action of propranolol on artificial membranes
    Sacha De Carlo
    Molecular and Cell Biology Department, Howard Hughes Medical Institute, University of California, Berkeley, California, USA
    J Liposome Res 14:61-76. 2004
    ..We are interested in the interaction of propranolol with artificial membranes, as liposomes of controllable size are used as biocompatible and protective structures to encapsulate ..
  35. ncbi Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial
    Maurizio S Tonetti
    Department of Periodontology, Eastman Dental Institute, University College London, London, UK
    J Clin Periodontol 31:770-6. 2004
    ....
  36. ncbi Membrane ion-exchange chromatography for process-scale antibody purification
    H L Knudsen
    Department of Recovery Sciences, Genentech, Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 907:145-54. 2001
    ..However, anion-exchange membranes in a flow-through mode may provide a reasonable alternative to columns for the removal of low levels of impurities such as DNA, host cell protein, and virus...
  37. ncbi QSAR study on permeability of hydrophobic compounds with artificial membranes
    Masaaki Fujikawa
    Division of Environmental Science and Technology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Bioorg Med Chem 15:3756-67. 2007
    ....
  38. ncbi Haemocompatibility of amorphous hydrogenated carbon thin films, optical properties and adsorption mechanisms of blood plasma proteins
    S Lousinian
    Aristotle University of Thessaloniki, Department of Physics, GR 54124 Thessaloniki, Greece
    Biomol Eng 24:107-12. 2007
    ..Adsorption mechanisms were studied through AFM technique too. AFM results are in accordance with those derived by SE. Combination of the two techniques gives us a more accurate description of protein adsorption mechanisms...
  39. ncbi The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants
    C H Hammerle
    Department of Periodontology and Fixed Prosthodontics, University of Bern, Switzerland
    Clin Oral Implants Res 9:151-62. 1998
    ..In conclusion, Bio-Oss exhibited osteoconductive properties and hence can be recommended for GBR procedures in dehiscence defects with respect to vertical and horizontal growth of bone...
  40. pmc Measuring distances in supported bilayers by fluorescence interference-contrast microscopy: polymer supports and SNARE proteins
    Volker Kiessling
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908 0736, USA
    Biophys J 84:408-18. 2003
    ..The distance of the GFP from the membrane surface was 16.5 +/- 2.8 nm, indicating an upright orientation of the rod-shaped t-SNARE/v-SNARE complex from the membrane surface...
  41. ncbi Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO)
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, 6500 Nijmegen, The Netherlands
    J Clin Periodontol 32:720-4. 2005
    ....
  42. ncbi Probing the structure of supported membranes and tethered oligonucleotides by fluorescence interference contrast microscopy
    Caroline M Ajo-Franklin
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Langmuir 21:4976-83. 2005
    ....
  43. ncbi Combination use of bovine porous bone mineral, enamel matrix proteins, and a bioabsorbable membrane in intrabony periodontal defects in humans
    V Lekovic
    University of California, Los Angeles, School of Dentistry, 90095, USA
    J Periodontol 72:583-9. 2001
    ..Differences observed were both statistically and clinically significant. The exact role of each of the 3 technique components in achieving the clinical improvement observed in this study remains to be determined...
  44. ncbi Evaluation of nanopores as candidates for electronic analyte detection
    Jonathan Nakane
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC, Canada V6T 1Z1
    Electrophoresis 23:2592-601. 2002
    ..Experimental and model results are extrapolated to predict the capture rate of synthetic pores operating at higher voltages than presently achievable with protein pores...
  45. ncbi Protein separation using membrane chromatography: opportunities and challenges
    Raja Ghosh
    Department of Engineering Science, University of Oxford, UK
    J Chromatogr A 952:13-27. 2002
    ..The technical challenges facing membrane chromatography are highlighted and the scope for future work is discussed...
  46. ncbi Treatment of peri-implant defects with guided bone regeneration: a comparative clinical study with various membranes and bone grafts
    M Lorenzoni
    Department of Prosthodontics, School of Dentistry, University of Graz, Austria
    Int J Oral Maxillofac Implants 13:639-46. 1998
    ..001). Barrier membranes represent a valid technique for the treatment of peri-implant defects. Clinical and histologic results showed that Bio-Oss is an osteoconductive scaffold that promotes new bone formation...
  47. ncbi Molecular transport and organization in supported lipid membranes
    S G Boxer
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Curr Opin Chem Biol 4:704-9. 2000
    ..Controlled interactions between supported membranes and cells, particularly from the immune system, provide direct insight into cell-cell surface interactions...
  48. ncbi Compartmentalized bone regeneration of cranial defects with biodegradable barriers: an animal model
    S Stal
    Baylor College of Medicine, 1102 Bates #330, MC 3-2314, Houston, Texas 77030, USA
    J Craniofac Surg 12:41-7. 2001
    ..This paper is unique because resorbable material in the animal model is relatively inexpensive and easy to use and has allowed successful autogenous bony regeneration...
  49. ncbi A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans
    P M Camargo
    University of California, Los Angeles, School of Dentistry, 90095, USA
    J Clin Periodontol 27:889-96. 2000
    ....
  50. ncbi Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst
    A Avdeef
    pION INC, 5 Constitution Way, Woburn, MA 01801, USA
    Eur J Pharm Sci 14:271-80. 2001
    ..of 23 drug and natural product molecules was made using the in vitro model based on filter-immobilized artificial membranes (filter-IAM), assembled from phosphatidylcholine in dodecane, in buffer solutions at pH 7.4...
  51. ncbi Characterization and application of strong ion-exchange membrane adsorbers as stationary phases in high-performance liquid chromatography of proteins
    O W Reif
    , , Germany
    J Chromatogr A 654:29-41. 1993
    ..Appropriate conditions were defined for the separation of human serum and for the isolation of subtilisin Carlsberg and beta-galactosidase from cell culture supernatants...
  52. ncbi Periodontal surgery of vertical bony defects with or without synthetic bioabsorbable barriers. 12-month results
    P Eickholz
    Department of Operative Dentistry and Periodontology, Dental School, Ruprecht Karls University Heidelberg, Germany
    J Periodontol 69:1210-7. 1998
    ..Hence, the use of bioabsorbable barriers for therapy of intrabony defects may be recommended...
  53. ncbi Immobilization of biomaterials to nano-assembled films (self-assembled monolayers, Langmuir-Blodgett films, and layer-by-layer assemblies) and their related functions
    Katsuhiko Ariga
    Supermolecules Group, National Institute for Materials Science, 1 1 Namiki, Tsukuba 305 0044, Japan
    J Nanosci Nanotechnol 6:2278-301. 2006
    ..LBL assemblies were also utilized for sensors and drug delivery systems. This kind of assembling structures can be prepared on micro-size particle and very useful for preparation of hollow capsules with biological functions...
  54. ncbi Calcium modulates the mechanical properties of anionic phospholipid membranes
    Scott D Shoemaker
    Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA
    J Colloid Interface Sci 266:314-21. 2003
    ..This is likely due to a lateral phase separation in the membrane. By combining mechanical properties with fluorescence observations we propose that the PA-rich phase separates into small unconnected domains...
  55. ncbi Membrane processes in biotechnology: an overview
    Catherine Charcosset
    Laboratoire d Automatique et de Génie des Procédés, UMR CNRS 5007, UCBLyon 1, ESCPE Lyon, 43 Bd du 11 Novembre 1918, 69 622 Villeurbanne Cedex, France
    Biotechnol Adv 24:482-92. 2006
    ..This review presents these various membrane processes by focusing more precisely on membrane materials, module design, operating parameters and the large range of possible applications...
  56. ncbi Performance of a membrane adsorber for trace impurity removal in biotechnology manufacturing
    Michael Phillips
    Biopharmaceutical R and D Division, Millipore Corp, 32 Wiggins Ave, Bedford, MA 01730, USA
    J Chromatogr A 1078:74-82. 2005
    ..The rigid microporous structure of the membrane layers allows for high process flux operation and uniform bed consistency at all processing scales...
  57. ncbi Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA, USA
    J Clin Periodontol 31:725-9. 2004
    ..The objective of this study was to evaluate the effect of a space-providing coral-derived biomaterial on alveolar bone regeneration in conjunction with GTR...
  58. ncbi Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter study
    Zane Cohen
    Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Dis Colon Rectum 48:1130-9. 2005
    ..This study was designed to assess the safety of glycerol hyaluronate/carboxymethylcellulose and to evaluate its efficacy in reducing the incidence, extent, and severity of postoperative adhesion development in surgical patients...
  59. ncbi Results after laparoscopic lysis of adhesions and placement of seprafilm for intractable abdominal pain
    L Khaitan
    Department of Surgery, Vanderbilt University Medical Center, D5203 MCN, Nashville, TN 37232, USA
    Surg Endosc 17:247-53. 2003
    ..We report our experience with treatment of this challenging patient population using laparoscopic lysis of adhesions (LOA) and placement of Seprafilm (Genzyme, Cambridge, MA, USA)...
  60. ncbi Longitudinal membrane function in functionally anuric patients treated with APD: data from EAPOS on the effects of glucose and icodextrin prescription
    Simon J Davies
    North Staffordshire Hospital, Stoke on Trent, UK Charing Cross Hospital, London, UK
    Kidney Int 67:1609-15. 2005
    ..Factors driving these changes are thought to include hypertonic glucose exposure, but previously reported associations are confounded by the presence of residual renal function...
  61. ncbi The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers
    Jan Stange
    Division of Gastroenterology, Hepatology, UCSD Medical Center, San Diego, California 92103 8413, USA
    Artif Organs 26:103-10. 2002
    ..MARS has been used in 26 patients with acute liver failure or primary graft dysfunction. Nineteen centers reporting on 103 patients have shown that MARS treatment is safe, easy to handle, feasible, and effective...
  62. ncbi Dual functional, polymeric self-assembled monolayers as a facile platform for construction of patterns of biomolecules
    Sangjin Park
    Research Center for Biomolecular Nanotechnology, Department of Life Science, GIST, 1 Oryong dong, Buk Gu, Gwangju 500 712, Korea
    Langmuir 23:10902-5. 2007
    ..Taken together, the present dual functional, random copolymers may have warrant applications in the field of biosensors and biochips...
  63. ncbi Significantly improved adhesion of poly(3,4-ethylenedioxythiophene) nanofilms to amino-silane monolayer pre-patterned SiO2 surfaces
    Ilsun Pang
    Center for Materials and Processes of Self Assembly, School of Advanced Materials Engineering, Kookmin University, Seoul 136 702, Korea
    J Nanosci Nanotechnol 7:3792-4. 2007
    ..The evaluation revealed that the newly developed bottom-up process can successfully offer a strongly adhered and selectively patterned PEDOT nanofilm on an oxidized Si wafer surface...
  64. ncbi Tuning compliance of nanoscale polyelectrolyte multilayers to modulate cell adhesion
    Michael T Thompson
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biomaterials 26:6836-45. 2005
    ....
  65. ncbi Micro orientation and anisotropy of conductivity in liquid crystalline polymer films filled with carbon nanotubes
    V N Bliznyuk
    Materials Science and Engineering Department, Western Michigan University, Kalamazoo, MI 49008, USA
    J Nanosci Nanotechnol 5:1651-5. 2005
    ....
  66. ncbi Robust inorganic membranes from detachable ultrathin tantalum oxide films
    Sherdeep Singh
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada
    Nano Lett 7:2676-83. 2007
    ..Our membranes are mechanically, chemically, and thermally robust, have a high dielectric constant, and a high refractive index, making them potentially useful in sensors, optics, filtration, and catalysis...
  67. ncbi Surface modification of poly(L-lactic acid) membrane via layer-by-layer assembly of silver nanoparticle-embedded polyelectrolyte multilayer
    Da Guang Yu
    Department of Textile Science, Nanya Institute of Technology, Chung Li, Tao Yuan, Taiwan
    Bioconjug Chem 18:1521-9. 2007
    ..Overall results demonstrated that such a fast, easy processing and shape-independent method for an antithrombogenic coating can be used for applications in hemodialysis devices...
  68. ncbi Infrared optical properties and AFM of spin-cast chitosan films chemically modified with 1,2 Epoxy-3-phenoxy-propane
    W H Nosal
    Department of Electrical Engineering, University of Nebraska, Lincoln, NE 68588, USA
    Colloids Surf B Biointerfaces 46:26-31. 2005
    ....
  69. ncbi The physical properties and response of osteoblasts to solution cast films of PLGA doped polycaprolactone
    Z G Tang
    UK Centre for Tissue Engineering, University of Liverpool, Liverpool, UK
    Biomaterials 26:6618-24. 2005
    ..The doped PCL film registered a lower contact angle and increased hydrophilicity. Osteoblast cells attached to all doped materials, the 10% and 20% doped materials demonstrating the greatest cell growth...
  70. ncbi Fabrication of novel multilayered thin films based on inclusion complex formation between amylose derivatives and guest polymers
    Toshiyuki Kida
    Department of Applied Chemistry, Graduate School of Engineering, Osaka Univesity, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Langmuir 24:9227-9. 2008
    ..When MAs with 8 and 20% methylation were used as hosts, the formation of LbL assembly films with PTHF was clearly observed. On the other hand, MAs with more than 33% methylation barely formed LbL assembly films with PTHF...
  71. ncbi Nanoscale characterization of carbazole-indole copolymers modified carbon fiber surfaces
    A Sezai Sarac
    Istanbul Technical University, Department of Chemistry, Istanbul, Turkey
    J Nanosci Nanotechnol 5:1677-82. 2005
    ..3 and 0.9 microm, for two different composition of carbazole/indole on the carbon fiber. The carbon fibers coated with copolymer thin films were from 6.5 to 8.2 microm in diameter (from AFM measurement)...
  72. ncbi A method for reproducibly preparing synthetic nanopores for resistive-pulse biosensors
    John E Wharton
    Department of Chemistry and Center for Research at the Bio Nano Interface, University of Florida, Gainesville, FL 32611 7200, USA
    Small 3:1424-30. 2007
    ..This method and model constitute important steps toward developing practical, real-world, artificial-nanopore biosensors...
  73. ncbi The degradation of the three layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane in vitro
    Susan Liao
    Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 8586, Japan
    Dent Mater 23:1120-8. 2007
    ....
  74. ncbi Mesoporous bragg stack color tunable sensors
    Sung Yeun Choi
    Materials Chemistry Research Group, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Nano Lett 6:2456-61. 2006
    ..Furthermore, we demonstrate that the chemical sensing ability can be tuned via layer thickness, composition and surface properties...
  75. ncbi Small-diameter porous poly (epsilon-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells
    James R McMillan
    Department of Dermatology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    Tissue Eng 13:789-98. 2007
    ..These characteristics are considered important in developing grafts for use in the treatment of human skin wounds...
  76. ncbi Catalytic membranes prepared using layer-by-layer adsorption of polyelectrolyte/metal nanoparticle films in porous supports
    David M Dotzauer
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Nano Lett 6:2268-72. 2006
    ..Modified alumina membranes reduce >99% of 0.4 mM 4-nitrophenol at linear flow rates of 0.98 cm/s, and the modification process is also applicable to track-etched polycarbonate supports...
  77. ncbi Conical nanopore membranes: controlling the nanopore shape
    C Chad Harrell
    Department of Chemistry, and Center for Research at the Bio Nano Interface, University of Florida, Gainesville, FL 32611 7200, USA
    Small 2:194-8. 2006
  78. ncbi Fabrication and characterization of nanopore array
    Yongqi Fu
    Precision Engineering and Nanotechnology Center, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore
    J Nanosci Nanotechnol 6:1954-60. 2006
    ..The nanopore arrays were characterized using transmission electron microscopy (TEM) after the FIB drilling...
  79. ncbi Morphological and optical characterization of polyelectrolyte multilayers incorporating nanocrystalline cellulose
    Emily D Cranston
    Department of Chemistry, Pulp and Paper Research Centre, McGill University, Montreal, Quebec, H3A 2A7 Canada
    Biomacromolecules 7:2522-30. 2006
    ..The relationship between film color and thickness is discussed according to the principles of thin film interference and indicates that the iridescent properties of the films can be easily tailored in this system...
  80. ncbi Hybrid organic-inorganic nanostructures fabricated from layer-by-layer self-assembled multilayers of hyperbranched polyglycerols and phosphorus dendrimers
    Dong Ha Kim
    Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
    J Nanosci Nanotechnol 6:3871-6. 2006
    ..The resulting hybrid films exhibit characteristic photoluminescence (PL) properties...
  81. ncbi Degradation of electrospun PLGA-chitosan/PVA membranes and their cytocompatibility in vitro
    Bin Duan
    School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China
    J Biomater Sci Polym Ed 18:95-115. 2007
    ..Therefore, the results suggest that the composite membranes can positively mimic the structure of natural extracellular matrices and have the potential for application as three-dimensional tissue-engineering scaffolds...
  82. ncbi Preparation and characterization of stimuli-resistible hydrogels nano-coated with polyelectrolyte multilayer films
    Hirokazu Sakaguchi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan
    J Nanosci Nanotechnol 6:1124-7. 2006
    ..g., pH, ionic strength). Consequently, tolerant ionic hydrogels may be prepared by the nano-coating of hydrogel surfaces with PEM films and may be useful for technological and biomedical applications...
  83. ncbi A PLGA membrane controlling cell behaviour for promoting tissue regeneration
    G Rh Owen
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, 2199 Westbrook Mall, University of British Columbia, Vancouver, Canada V6T 1Z3
    Biomaterials 26:7447-56. 2005
    ..Addition of appropriate surface topographies to membranes used in guided tissue regeneration has the possibility of improving clinical performance in periodontal tissue regeneration procedures...
  84. ncbi The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering
    Fergal J O'Brien
    Department of Anatomy, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin, Ireland
    Technol Health Care 15:3-17. 2007
    ....
  85. ncbi Biomimetic micropatterning of silica by surface-initiated polymerization and microcontact printing
    Dong Jin Kim
    Department of Chemistry and School of Molecular Science BK21, Center for Molecular Design and Synthesis, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Small 1:992-6. 2005
    ..The procedure could be extended to the controlled fabrication of silica patterns with any size, shape, or thickness...
  86. ncbi Electrospun fine-textured scaffolds for heart tissue constructs
    Xinhua Zong
    Department of Chemistry, State University of New York at Stony Brook, 11794, USA
    Biomaterials 26:5330-8. 2005
    ..Electrospinning is a versatile manufacturing technique for design of biomaterials with potentially reorganizable architecture for cell and tissue growth...
  87. ncbi Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach
    Zhi Kang Xu
    Institute of Polymer Science and Department of Chemistry, Zhejiang University, Hangzhou 310027, People s Republic of China
    Langmuir 20:1481-8. 2004
    ..All these results demonstrate that the described approach is an effective way to improve the surface biocompatibility for polymeric membranes...
  88. doi Nanopores: a makeover for membranes
    Lane A Baker
    Nat Nanotechnol 3:73-4. 2008
  89. pmc Impedance analysis and single-channel recordings on nano-black lipid membranes based on porous alumina
    Winfried Römer
    Institut für Analytische Chemie, Chemo und Biosensorik, Universitat Regensburg, 93040 Regensburg, Germany
    Biophys J 86:955-65. 2004
    ..6 x 10(8) Omega cm(2). These high membrane resistances allowed for single-channel recordings. Gramicidin as well as alamethicin was successfully inserted into the nano-BLMs exhibiting characteristic conductance states...
  90. ncbi Hemocompatibility of poly(ether imide) membranes functionalized with carboxylic groups
    R Tzoneva
    Institute of Biophysics, Bulgarian Academy of Sciences, Acad G Bonchev St, Bl 108, Sofia 1113, Bulgaria
    J Mater Sci Mater Med 19:3203-10. 2008
    ..However, overall the hemocompatibility of all PEI membranes was higher than that of PET...
  91. ncbi An evaluation of bacterial contamination of barriers used in periapical tissue regeneration: Part 1--Bacterial adherence
    Priya Sharma
    Department of Endodontics, Prosthodontics, and Operative Dentistry, Baltimore College of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Quintessence Int 39:159-63. 2008
    ..It was hypothesized that OsseoQuest would show increased bacterial adherence compared to Lambone and Atrisorb...
  92. ncbi Technique paper for wet-spinning poly(L-lactic acid) and poly(DL-lactide-co-glycolide) monofilament fibers
    Kevin D Nelson
    Joint Program in Biomedical Engineering, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 76019 0138, USA
    Tissue Eng 9:1323-30. 2003
    ..This wet-extrusion process is simple and inexpensive enough to be carried out in almost any laboratory interested in tissue engineering...
  93. ncbi Polyethylene/phospholipid polymer alloy as an alternative to poly(vinylchloride)-based materials
    Kazuhiko Ishihara
    Department of Materials Engineering, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Biomaterials 25:1115-22. 2004
    ..We finally concluded that the PE/PMPC alloy could be used as biomaterials instead of poly(vinyl chloride)-based materials...
  94. ncbi Rapid fibroblast adhesion to 27nm high polymer demixed nano-topography
    M J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow, G12 8QQ, UK
    Biomaterials 25:77-83. 2004
    ..The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture...
  95. ncbi Physicochemical and blood compatibility characterization of polypyrrole surface functionalized with heparin
    Yali Li
    Department of Chemical and Environmental Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Republic of Singapore
    Biotechnol Bioeng 84:305-13. 2003
    ..Electrical stimulation also plays a positive role in decreasing platelet adhesion and increasing PRT on pristine and surface-modified PPY films...
  96. ncbi Modification of porous aminopropyl-silicate microcapsule membrane by electrically-bonded external anionic polymers
    Shinji Sakai
    Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Biomater Sci Polym Ed 14:643-52. 2003
    ..At the same time, it is suggested the influence on the permeability has to be investigated to develop an optimal microcapsule for bioartificial pancreas...
  97. ncbi Platelet compatible blood filtration fabrics using a phosphorylcholine polymer having high surface mobility
    Yasuhiko Iwasaki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biomaterials 24:3599-604. 2003
    ..On the other hand, the platelets adhered to the PET fabric and to that coated with PMB. Based on these results, we concluded that the higher mobility of the polymer chain is very important to reduce interactions with platelets...
  98. ncbi Phospholipid membranes as substrates for polymer adsorption
    Anne Feng Xie
    Department of Materials Science and Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Nat Mater 1:129-33. 2002
    ....
  99. ncbi Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique
    Qingpu Hou
    Faculty of Chemical Technology, Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology BMTI, University of Twente, PO Box 217, 7500 AE, Enschede, Netherlands
    Biomaterials 24:1937-47. 2003
    ....
  100. ncbi Polymers in nephrology. Characteristics and needs
    J Vienken
    Bioscience Department, Fresenius Medical Care, Bad Homburg, Germany
    Int J Artif Organs 25:470-9. 2002
    ..Compromises have to be found between properties and application. Polymer selection for application in nephrology has always to be made under the premise of final application...
  101. ncbi Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact
    Rena M Cornelius
    Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada
    Biomaterials 23:3583-7. 2002
    ..It appears that apolipoprotein A-I and/or HDL deposition may be an important effect in blood-biomaterial interactions generally, and one that has been largely overlooked...

Research Grants62

  1. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2013
    ..We have validated this platform with membrane-free systems and with artificial membranes for binding kinetics measurements...
  2. Bax function in apoptosis
    DONALD DAVID NEWMEYER; Fiscal Year: 2013
    ..Our studies will use cell-free systems we have developed, using either artificial membranes or isolated outer mitochondrial membranes, to help uncover the basic mechanisms through which Bax forms ..
  3. Regulation of the hematopoietic-cell transmembrane phosphatases CD45 and CD148
    Tanya S Freedman; Fiscal Year: 2010
    ..Using the purified cytoplasmic domains of CD45 and CD148 localized to artificial membranes, I will examine whether dimerization inhibits phosphatase activity...
  4. Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes
    STEVEN SCOTT SAAVEDRA; Fiscal Year: 2013
    ..b) Key structure-activity relationships of ICCRs in artificial membranes will be examined, such as the orientation and stoichiometry of the IC and GPCR subunits in functional ICCRs,..
  5. CONTROL OF VIRUS INDUCED LYSIS
    RYLAND F YOUNG; Fiscal Year: 2013
    ..Experiments are proposed to find ways to put purified holin proteins into artificial membranes under energized conditions...
  6. High throughput cell-free ion channel screening workstation
    Jason L Poulos; Fiscal Year: 2013
    ..Librede's patent pending formulation of cell-free artificial membranes can enable higher throughput and lower consumable costs while requiring less expensive equipment and ..
  7. Droplet Method for Bilayer Assays
    Gregory W Faris; Fiscal Year: 2010
    ..proteins require creating an artificial membrane to hold the protein, but existing methods for producing artificial membranes, such as the black lipid membrane and membranes with solid support, cannot be adapted to high- throughput ..
  8. Amyloid ion channels to design therapeutics for neurodegenerative diseases
    Ratneshwar Lal; Fiscal Year: 2013
    ..Indeed, amyloidogenic peptides induce ionic conductances in both native cell as well as artificial membranes. Structural study of membrane-bound amyloid complexes has been limited...
  9. CALCIUM REGULATION OF SECRETION IN NEUROENDOCRINE CELLS
    Thomas F J Martin; Fiscal Year: 2013
    ..of the work include imaging of CAPS and SNAREs at sites of exocytosis, reconstituting priming by CAPS on artificial membranes, and structural studies of CAPS tetramers and its SNARE-binding domain...
  10. Structure and Mechanism of a Virtual Proton Pump
    Christopher Miller; Fiscal Year: 2013
    ..This particular APC protein may be overexpressed, purified, functionally reconstituted in artificial membranes, and, most importantly, crystallized...
  11. Development of a disposable cell-free ion channel measurement platform for hERG s
    JASON POULOS; Fiscal Year: 2012
    ..Librede's patent pending formulation of cell-free artificial membranes can enable higher throughput and lower consumable costs while requiring less expensive equipment and ..
  12. Human ion channel pharmacology in droplet bilayer membranes
    Jason L Poulos; Fiscal Year: 2013
    ..ready prototype array plate, and verified its reliability and high yield by using it to create over 1000 artificial membranes. In the Phase II work proposed here, we will validate our platform with four ion channels: hERG, Kv7...
  13. 300MHZ NMR SPECTROMETER FOR MEDICINAL CHEMISTRY RESEARCH
    VINCENT DAVISSON; Fiscal Year: 1992
    ..to study the structures and dynamics of phospholipids that are covalently linked to silica (immobilized artificial membranes). Dr...
  14. ASSEMBLY OF CAB POLYPEPTIDES
    Neil Hoffman; Fiscal Year: 1993
    ..to reconstitute assembly in subthylakoid systems using membranes enriched in either PS I or PS II and artificial membranes reconstituted with reaction centers devoid of LHC...
  15. UTERINE RELAXING FACTORS: MOLECULAR ASPECTS OF ACTION
    BARBARA SANBORN; Fiscal Year: 2001
    ..The effect of phosphorylation of specific components on activity in the cell and in reconstituted artificial membranes will be explored and the effect of cell permeable protein kinase A anchor inhibitors on the ability of ..
  16. NOVEL DEVICE FOR FABRICATION OF ARTIFICIAL MEMBRANES
    FATEMEH MOJTABAI; Fiscal Year: 1990
    ..will be to: (1) develop an innovative technology for fabrication and in situ characterization of planar artificial membranes and (2) implement this technology with an advanced surface-selective optical illumination technique for ..
  17. Environmentally Responsive Nano0pores
    Ilya Zharov; Fiscal Year: 2007
    We propose to develop artificial membranes containing nanoscale pores whose mechanical, electrical, and chemical properties are controlled at a nanoscale with organic molecules...
  18. RECONSTITUTION OF NEURONAL CALCIUM CHANNELS
    Robert Rosenberg; Fiscal Year: 1993
    ..phosphorylation in maintaining active Ca channels be obtained in the cell-free system? Can Ca channels in artificial membranes be modulated by phosphorylation or by direct interactions with purified G-proteins? These questions can be ..
  19. STUDIES OF POLYHYDROXYCYCLOALKANES
    HENRY SABLE; Fiscal Year: 1980
    ..The analogs will also be used to prepare artificial membranes, and as substrates for various phospholipases and enzymes in the pathway of synthesis of these ..
  20. BIOCHEMISTRY OF PHOTORECEPTOR CELLS
    Meredithe Applebury; Fiscal Year: 1980
    ..enzymatic activities and their functional role in visual transduction, in vitro reconstituted systems of artificial membranes containing the photoreceptor rhodopsin and various combinations of the enzymes are examined...
  21. STRUCTURE AND FUNCTION OF PEPTIDE INCLUSION COMPLEXES
    BALTHASAR GISIN; Fiscal Year: 1980
    ..Porin, an outer membrane protein of E. coli will be reconstituted in artificial membranes. Chemical modification will be performed with the aim to produce pores that are highly anion or cation ..
  22. MECHANISMS OF BILE FORMATION
    Paul King; Fiscal Year: 1992
    Live animals, perfused organs, isolated cells, and artificial membranes are used to explore the physiology of bile formation and hepatic solute transport at a fundamental level...
  23. CARRIERS AND CHANNELS IN BIOLOGICAL SYSTEMS
    Adil Shamoo; Fiscal Year: 1980
    ..The model compounds which serve either as carriers or channels in artificial membranes were either from microbial organisms (antibiotic ionophores) or synthetic compounds...
  24. MECHANISMS OF BILE FORMATION
    EDSON FORKER; Fiscal Year: 1991
    Live animals, perfused organs, isolated cells, and artificial membranes are used to explore the physiology of bile formation and hepatic solute transport at a fundamental level...
  25. BUCCAL DELIVERY OF PROCHLORPERAZINE (ANTI-EMETIC)
    LO WHE YONG; Fiscal Year: 1992
    ..In vitro testing will include adhesive, flexural, storage stability, and drug permeability testing. Drug permeation will be measured using a commercially available cell and both natural (mucosal) and artificial membranes.
  26. ELECTROMAGNETIC WAVES BIOLOGICAL MEMBRANES INTERACTION
    Frank Barnes; Fiscal Year: 1980
    ..Our data on the variations of impedance of artificial membranes will be extended to include illumination with discontinuities that have been observed in preliminary ..
  27. MOLECULAR ACTIONS OF VOLATILE ANESTHETICS ON G-PROTEINS
    Mario Rebecchi; Fiscal Year: 2003
    ..receptor/effector coupling by locking the Galpha subunit into a complex with Gbetagamma will be tested on artificial membranes by measuring the lateral interactions of these proteins using fluorescence resonance energy transfer...
  28. In vitro selection of nicotinamide-binding peptides
    SHEREF MANSY; Fiscal Year: 2006
    ..Such progressions may ultimately allow for the generation of synthetic pathways that could either be inserted into bacterial chromosomes or encapsulated in artificial membranes.
  29. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  30. BioMEMS Model of Glomerular Function
    WILLIAM FISSELL; Fiscal Year: 2008
    ..Third, HP and s will be measured for the NM-PBM membrane. Fourth, data from (1-3) will be compared with existing predictive models of glomerular function. ..
  31. BioMEMS Materials for Renal Tissue Engineering
    WILLIAM FISSELL; Fiscal Year: 2004
    ..Failure of RPTCs to grow on these substrates despite a variety of suface modifications would be extremely important, as it would indicate a need for new materials in bioengineering. ..
  32. 2005 Supramolecules and Assemblies, Chemistry of Gordon Conference
    David Thompson; Fiscal Year: 2005
    ..This proposal requests funds to supplement travel costs associated with this meeting. ..
  33. One dimensional transport equations for CE systems by asymptotic homogenization
    Sandip Ghosal; Fiscal Year: 2009
    ..The emergence of such devices would have an enormous impact on human health as they would enable biochemical analyses (such as DNA sequencing) that currently take months or years to be completed in minutes. ..
  34. HIGH RESOLUTION MEMBRANE STRUCTURE FROM FLUORESCENCE
    Erwin London; Fiscal Year: 2009
    ..Whether proteins interact differently with ordinary and ceramide-rich rafts will also be determined. Finally, the degree to which proteins can regulate raft formation will be studied. ..
  35. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  36. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  37. Acquisition of a Cryogenic Field Emission EM
    David Thompson; Fiscal Year: 2004
    ....
  38. Diphtheria Toxin: Structure and Membrane Interaction
    Erwin London; Fiscal Year: 2006
    ..In a first step, the effects of molecules found to inhibit T domain pore formation upon YobB/D and Yersinia pathogenesis will be tested. ..
  39. SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID
    Douglas Borchman; Fiscal Year: 2003
    ..An understanding of these alterations will facilitate the development of therapies to prevent or perhaps even reverse these changes. ..
  40. Conference on Muscle: Excitation-Contraction Coupling
    Martin Schneider; Fiscal Year: 2003
    ..The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible. ..
  41. IMPROVING THE DETECTION LIMIT OF POTENTIOMETRIC SENSORS
    Eric Bakker; Fiscal Year: 2002
    ..Miniature, micrometer sized optical sensor based on the same ionophoric membrane components will be optimized for low detection limit applications and their performance critically compared to their potentiometric counterparts. ..
  42. SYNTHESIS OF TRIGGERABLE FUSOGENS FOR MEMBRANE BILAYERS
    David Thompson; Fiscal Year: 2001
    ..g., peptides, antisense oligonucleotides, and plasmids). ..
  43. NUTRITION AND METABOLISM IN ACUTE RENAL FAILURE
    Jonathan Himmelfarb; Fiscal Year: 2001
    ..The feasibility of implementing an optimized nutritional regimen and measuring the effects on nutritional and metabolic parameters will also be performed. ..
  44. IONOPHORE-BASED CHEMICAL ION SENSORS
    Eric Bakker; Fiscal Year: 2001
    ....
  45. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
    ..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
  46. Highly Elastic pH-sensitive Cationic Liposomes
    Michalakis Savva; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  47. ANTICANCER DRUG EXPULSION IN SHED VESICLES
    GUS ROSANIA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  48. 3D Culture of mES Cells in Four-Compartment Bioreactors
    JOERG GERLACH; Fiscal Year: 2006
    ..abstract_text> ..
  49. LIPID CONTROL OF MEMBRANE PROTEIN ORGANIZATION
    Richard Mendelsohn; Fiscal Year: 2007
    ..Finally, the sensitivity of vibrational spectra to molecular structure will be used to map the effects of penetration enhancers on lipid conformation and protein secondary structure. [unreadable] [unreadable]..
  50. Molecular Patterning via Photocatalytic Nanolithography
    Jane Bearinger; Fiscal Year: 2005
    ..Document repeatable surface patterning of cells using photocatalysis and biocompatible surface chemistries 5. Demonstrate nanometer scale surface patterning with proteins and DNA ..
  51. Local Ca2+ signaling in sympathetic ganglion neurons
    Martin Schneider; Fiscal Year: 2005
    ..Our results will provide new insights regarding local Ca2+ signaling mechanisms that could be compromised in neuronal disease. ..
  52. Crystallization of His-tag Proteins on Nanostructured 1D & 2D Template Interface
    David Thompson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Activity Dependent Signaling in Muscle Fiber Plasticity
    Martin Schneider; Fiscal Year: 2007
    ..The studies proposed here should have important bearing on the effects of use and disuse on muscle fiber gene expression. [unreadable] [unreadable]..
  54. Quantification of Host Markers in GCF Using CBIB
    Ricardo Teles; Fiscal Year: 2007
    ..Moreover, this methodology is at the forefront of new approaches in proteomics, and carries enormous promise for translational applications in the near future. [unreadable] [unreadable]..
  55. Scavenger Receptor BI in Cellular Cholesterol Metabolism
    Erwin London; Fiscal Year: 2008
    ..These studies will provide new and important information about SR-BI-mediated cholesterol flux and its role in RCT. ..
  56. Structure and function of antimicrobial peptides
    Ayyalusamy Ramamoorthy; Fiscal Year: 2008
    ..These peptides have therapeutic potential as antibiotics and have particular importance for cystic fibrosis patients. ..
  57. Purchase of a 500 MHz Solid State NMR Spectrometer
    Ayyalusamy Ramamoorthy; Fiscal Year: 2007
    ..unreadable] [unreadable] All the major users of the instrument are supported by NIH R01 grants. [unreadable] [unreadable] [unreadable]..
  58. Development of an ICMT Supported Membrane Sensor
    David Thompson; Fiscal Year: 2009
    ..Future extension of this detector array concept could have far reaching potential for accelerating the discovery of new therapeutic agents targeted to many other classes of membrane-associated proteins. ..
  59. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
    ..These studies will provide novel insights into the physiological role of this important phospholipid, and could possibly open up novel therapeutic targets against inflammation and atherosclerosis. ..