glucosinolates

Summary

Summary: Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.

Top Publications

  1. pmc Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds
    D J Kliebenstein
    Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
    Genetics 159:359-70. 2001
  2. pmc Glucosinolate metabolites required for an Arabidopsis innate immune response
    Nicole K Clay
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 323:95-101. 2009
  3. ncbi Biology and biochemistry of glucosinolates
    Barbara Ann Halkier
    Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, DK 1871 Frederiksberg C, Denmark
    Annu Rev Plant Biol 57:303-33. 2006
  4. ncbi The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
  5. ncbi Glucosinolate biosynthetic genes in Brassica rapa
    Hui Wang
    Key Laboratory of Horticultural Crop Genetic Improvement, MOA, PR China
    Gene 487:135-42. 2011
  6. ncbi Biosynthesis of glucosinolates--gene discovery and beyond
    Ida E Sønderby
    Plant Biochemistry Laboratory, VKR Research Centre Pro Active Plants, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
    Trends Plant Sci 15:283-90. 2010
  7. ncbi Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics
    Masami Yokota Hirai
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 280:25590-5. 2005
  8. pmc Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis
    Masami Yokota Hirai
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 104:6478-83. 2007
  9. ncbi Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana
    Paul D Brown
    Department of Biochemistry, Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Phytochemistry 62:471-81. 2003
  10. ncbi HAG2/MYB76 and HAG3/MYB29 exert a specific and coordinated control on the regulation of aliphatic glucosinolate biosynthesis in Arabidopsis thaliana
    Tamara Gigolashvili
    Botanisches Institut der Universitat zu Koln, Gyrhofstrasse 15, D 50931 Köln, Germany
    New Phytol 177:627-42. 2008

Detail Information

Publications300 found, 100 shown here

  1. pmc Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds
    D J Kliebenstein
    Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
    Genetics 159:359-70. 2001
    ..We are studying the regulation of glucosinolates, a large group of secondary metabolites, in Arabidopsis to investigate how secondary metabolism is controlled...
  2. pmc Glucosinolate metabolites required for an Arabidopsis innate immune response
    Nicole K Clay
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 323:95-101. 2009
    ..Our study shows that well-studied plant metabolites, previously identified as important in avoiding damage by herbivores, are also required as a component of the plant defense response against microbial pathogens...
  3. ncbi Biology and biochemistry of glucosinolates
    Barbara Ann Halkier
    Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, DK 1871 Frederiksberg C, Denmark
    Annu Rev Plant Biol 57:303-33. 2006
    b>Glucosinolates are sulfur-rich, anionic natural products that upon hydrolysis by endogenous thioglucosidases called myrosinases produce several different products (e.g., isothiocyanates, thiocyanates, and nitriles)...
  4. ncbi The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
    b>Glucosinolates (beta-thioglucoside-N-hydroxysulfates), the precursors of isothiocyanates, are present in sixteen families of dicotyledonous angiosperms including a large number of edible species...
  5. ncbi Glucosinolate biosynthetic genes in Brassica rapa
    Hui Wang
    Key Laboratory of Horticultural Crop Genetic Improvement, MOA, PR China
    Gene 487:135-42. 2011
    b>Glucosinolates (GS) are a group of amino acid-derived secondary metabolites found throughout the Cruciferae family...
  6. ncbi Biosynthesis of glucosinolates--gene discovery and beyond
    Ida E Sønderby
    Plant Biochemistry Laboratory, VKR Research Centre Pro Active Plants, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
    Trends Plant Sci 15:283-90. 2010
    b>Glucosinolates are sulfur-rich secondary metabolites characteristic of the Brassicales order with important biological and economic roles in plant defense and human nutrition...
  7. ncbi Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics
    Masami Yokota Hirai
    Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 280:25590-5. 2005
    ..A group of metabolites/genes regulated by the same mechanism clustered together. The metabolism of glucosinolates was shown to be coordinately regulated...
  8. pmc Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis
    Masami Yokota Hirai
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 104:6478-83. 2007
    ..One of the intriguing, although poorly described metabolic pathways in plants is the biosynthesis of glucosinolates (GSLs), a group of bioactive secondary products derived from amino acids that are found in the family ..
  9. ncbi Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana
    Paul D Brown
    Department of Biochemistry, Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Phytochemistry 62:471-81. 2003
    ..5-3.3% by dry weight), followed by inflorescences, siliques (fruits), leaves and roots. While aliphatic glucosinolates predominated in most organs, indole glucosinolates made up nearly half of the total composition in roots and ..
  10. ncbi HAG2/MYB76 and HAG3/MYB29 exert a specific and coordinated control on the regulation of aliphatic glucosinolate biosynthesis in Arabidopsis thaliana
    Tamara Gigolashvili
    Botanisches Institut der Universitat zu Koln, Gyrhofstrasse 15, D 50931 Köln, Germany
    New Phytol 177:627-42. 2008
    ..both MYB factors on the steady-state level of glucosinolate biosynthetic genes and accumulation of aliphatic glucosinolates. Both HAG2/MYB76 and HAG3/MYB29 were shown to be positive regulators of aliphatic glucosinolate biosynthesis...
  11. ncbi Glucosinolates and isothiocyanates in health and disease
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Trends Mol Med 18:337-47. 2012
    b>Glucosinolates and isothiocyanates have both been objects of research for more than half a century...
  12. ncbi The microRNA miR393 re-directs secondary metabolite biosynthesis away from camalexin and towards glucosinolates
    Alexandre Robert-Seilaniantz
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich, UK
    Plant J 67:218-31. 2011
    ..We propose that miR393 levels can fine-tune plant defences and prioritize resources...
  13. pmc The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis
    John L Celenza
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Plant Physiol 137:253-62. 2005
    ..Together, this work implicates ATR1 as a key homeostatic regulator of Trp metabolism and suggests that ATR1 can be manipulated to coordinately control the suite of enzymes that synthesize IGs...
  14. ncbi The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana
    Tamara Gigolashvili
    Botanisches Institut der Universitat zu Koln, Gyrhofstrasse 15, Koln, Germany
    Plant J 51:247-61. 2007
    Methionine-derived glucosinolates belong to a class of plant secondary metabolites that serve as chemoprotective compounds in plant biotic defense reactions and also exhibit strong anticancerogenic properties beneficial to human health...
  15. ncbi Glucosinolate metabolism and its control
    C Douglas Grubb
    Department of Plant Sciences, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Trends Plant Sci 11:89-100. 2006
    b>Glucosinolates and their associated degradation products have long been recognized for their distinctive benefits to human nutrition and plant defense...
  16. ncbi Homoeologous loci control the accumulation of seed glucosinolates in oilseed rape (Brassica napus)
    P M Howell
    Brassica Genetics Group, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Genome 46:454-60. 2003
    ..Three of these loci also appeared to control the accumulation of seed glucosinolates in a Brassica napus L. 'Bienvenu' x 'Tapidor' cross, and accounted for 86% of the phenotypic variation...
  17. pmc Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects
    Inga Mewis
    Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, State College, Pennsylvania 16802, USA
    Plant Physiol 138:1149-62. 2005
    ..Our results indicate that exogenous signal application and plant consumption measures may not provide useful measures of plant responses to actual insect feeding...
  18. pmc Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways
    Michael Dalgaard Mikkelsen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, opgang 10, St, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 131:298-308. 2003
    b>Glucosinolates are natural plant products that function in the defense toward herbivores and pathogens...
  19. pmc Genetic control of natural variation in Arabidopsis glucosinolate accumulation
    D J Kliebenstein
    Department of Genetics and Evolution, Max Planck Institute of Chemical Ecology, Carl Zeiss Promenade 10, 07745 Jena, Germany
    Plant Physiol 126:811-25. 2001
    b>Glucosinolates are biologically active secondary metabolites of the Brassicaceae and related plant families that influence plant/insect interactions...
  20. ncbi Fine mapping of loci involved with glucosinolate biosynthesis in oilseed mustard (Brassica juncea) using genomic information from allied species
    N C Bisht
    Centre for Genetic Manipulation of Crop Plants, Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110 021, India
    Theor Appl Genet 118:413-21. 2009
    ..This study, therefore, provides clues to the genetic mechanism of 'Bronowski genes' controlling the glucosinolate trait and also provides efficient markers for marker-assisted introgression of low glucosinolate trait in B. juncea...
  21. ncbi Altering glucosinolate profiles modulates disease resistance in plants
    Günter Brader
    Division of Genetics, Department of Biological and Environmental Sciences, Faculty of Biosciences, Viikki Biocenter, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
    Plant J 46:758-67. 2006
    ..Here, we show that Arabidopsis plants with high levels of novel glucosinolates (GSs) as a result of the introduction of single CYP79 genes exhibit altered disease resistance...
  22. pmc Metabolic engineering in Nicotiana benthamiana reveals key enzyme functions in Arabidopsis indole glucosinolate modification
    Marina Pfalz
    Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
    Plant Cell 23:716-29. 2011
    Indole glucosinolates, derived from the amino acid Trp, are plant secondary metabolites that mediate numerous biological interactions between cruciferous plants and their natural enemies, such as herbivorous insects, pathogens, and other ..
  23. pmc Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana
    Stephanie Troufflard
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    BMC Plant Biol 10:172. 2010
    ..Whether and how K deficient plants also alter their secondary metabolism for nutrient management and defense is not known...
  24. ncbi The transcription factor HIG1/MYB51 regulates indolic glucosinolate biosynthesis in Arabidopsis thaliana
    Tamara Gigolashvili
    Botanisches Institut der Universitat zu Koln, Gyrhofstrasse 15, D 50931 Köln, Germany
    Plant J 50:886-901. 2007
    b>Glucosinolates are a class of plant secondary metabolites that serve as antiherbivore compounds in plant defence...
  25. pmc Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana
    Eva K F Chan
    Department of Plant Sciences, University of California Davis, Davis, California, United States of America
    PLoS Biol 9:e1001125. 2011
    ....
  26. ncbi Pseudomonas sax genes overcome aliphatic isothiocyanate-mediated non-host resistance in Arabidopsis
    Jun Fan
    John Innes Centre, Norwich NR4 7UH, UK
    Science 331:1185-8. 2011
    ..We found that sulforaphane (4-methylsulfinylbutyl isothiocyanate), a natural product derived from aliphatic glucosinolates, inhibits growth in Arabidopsis of non-host Pseudomonas bacteria in planta...
  27. ncbi Transcriptional responses of Arabidopsis thaliana ecotypes with different glucosinolate profiles after attack by polyphagous Myzus persicae and oligophagous Brevicoryne brassicae
    Anna Kusnierczyk
    Department of Biology, The Norwegian University of Science and Technology, Realfagbygget, 7491, Trondheim, Norway
    J Exp Bot 58:2537-52. 2007
    ..In cruciferous species, jasmonic acid, salicylic acid, and ethylene along with glucosinolates and their hydrolysis products play important roles in plant protection and plant-insect communication...
  28. pmc A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates
    Ida Elken Sønderby
    Plant Biochemistry Laboratory, Department of Plant Biology, Center for Molecular Plant Physiology PlaCe, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 2:e1322. 2007
    b>Glucosinolates are natural metabolites in the order Brassicales that defend plants against both herbivores and pathogens and can attract specialized insects. Knowledge about the genes controlling glucosinolate regulation is limited...
  29. pmc Jasmonate-dependent induction of indole glucosinolates in Arabidopsis by culture filtrates of the nonspecific pathogen Erwinia carotovora
    G Brader
    Department of Biosciences, University of Helsinki, POB 56, FIN-00014 Helsinki, Finland
    Plant Physiol 126:849-60. 2001
    ..activation we characterized the production of secondary defense metabolites such as camalexin and indole glucosinolates derived from precursors of this pathway...
  30. ncbi Myzus persicae (green peach aphid) feeding on Arabidopsis induces the formation of a deterrent indole glucosinolate
    Jae Hak Kim
    Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA
    Plant J 49:1008-19. 2007
    Cruciferous plants produce a wide variety of glucosinolates as a protection against herbivores and pathogens...
  31. ncbi Genome-wide identification of glucosinolate synthesis genes in Brassica rapa
    Yun Xiang Zang
    Genomics Division, Department of Agricultural Bio resources, National Academy of Agricultural Science, Rural Development Administration, Suwon, Korea
    FEBS J 276:3559-74. 2009
    b>Glucosinolates play important roles in plant defense against herbivores and microbes, as well as in human nutrition...
  32. pmc Long-distance phloem transport of glucosinolates in Arabidopsis
    S Chen
    Plant Biochemistry Laboratory and Center for Molecular Plant Physiology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 127:194-201. 2001
    b>Glucosinolates are a large group of plant secondary metabolites found mainly in the order Capparales, which includes a large number of economically important Brassica crops and the model plant Arabidopsis...
  33. ncbi Identification of indole glucosinolate breakdown products with antifeedant effects on Myzus persicae (green peach aphid)
    Jae Hak Kim
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Plant J 54:1015-26. 2008
    The cleavage of glucosinolates by myrosinase to produce toxic breakdown products is a characteristic insect defense of cruciferous plants...
  34. ncbi Glucosinolate structures in evolution
    Niels Agerbirk
    Section for Plant Biochemistry, Department of Plant Biology and Biotechnology, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark
    Phytochemistry 77:16-45. 2012
    By 2000, around 106 natural glucosinolates (GSLs) were probably documented. In the past decade, 26 additional natural GSL structures have been elucidated and documented...
  35. ncbi Formation of simple nitriles upon glucosinolate hydrolysis affects direct and indirect defense against the specialist herbivore, Pieris rapae
    Roland Mumm
    Laboratory of Entomology, Wageningen University, 6700 EH, Wageningen, The Netherlands
    J Chem Ecol 34:1311-21. 2008
    ..The defensive potential of glucosinolates is mainly due to the products formed after myrosinase-catalyzed hydrolysis upon tissue damage...
  36. ncbi Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L
    Richard N Bennett
    Phytochemicals, Nutrition Division, Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, Malawi
    J Agric Food Chem 51:3546-53. 2003
    ..oleifera from a wide variety of sources and M. stenopetala from a single source were analyzed for glucosinolates and phenolics (flavonoids, anthocyanins, proanthocyanidins, and cinnamates). M. oleifera and M...
  37. ncbi The ecological genetics of aliphatic glucosinolates
    A F Raybould
    Centre for Ecology and Hydrology, Winfrith Technology Centre, Dorchester, Dorset DT2 8ZD, UK
    Heredity (Edinb) 87:383-91. 2001
    b>Glucosinolates are plant secondary metabolites composed of a thioglucose group and an amino acid side-chain. They occur in the Brassicaceae and related families...
  38. pmc MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis
    Susanne Textor
    Department of Biochemistry, Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
    Plant Physiol 144:60-71. 2007
    Chain elongated, methionine (Met)-derived glucosinolates are a major class of secondary metabolites in Arabidopsis (Arabidopsis thaliana)...
  39. pmc Genetic architecture of plastic methyl jasmonate responses in Arabidopsis thaliana
    Daniel J Kliebenstein
    Department of Genetics and Evolution, Max Planck Institute for Chemical Ecology, Beutenberg Campus, 07745, Jena, Germany
    Genetics 161:1685-96. 2002
    ..Additionally, we present an analysis of MeJa and salicylic acid cross-talk in glucosinolate regulation and describe the implications for glucosinolate physiology and functional understanding of Arabidopsis MeJa signal transduction...
  40. ncbi Role of glucosinolates in insect-plant relationships and multitrophic interactions
    Richard J Hopkins
    Department of Ecology, Swedish University of Agricultural Sciences, Uppsala S 750 07, Sweden
    Annu Rev Entomol 54:57-83. 2009
    b>Glucosinolates present classical examples of plant compounds affecting insect-plant interactions. They are found mainly in the family Brassicaceae, which includes several important crops. More than 120 different glucosinolates are known...
  41. ncbi The cancer chemopreventive actions of phytochemicals derived from glucosinolates
    John D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Eur J Nutr 47:73-88. 2008
    ..It describes how isothiocyanates, thiocyanates, nitriles, cyano-epithioalkanes and indoles are produced from glucosinolates through the actions of myrosinase, epithiospecifier protein and epithiospecifier modifier protein released ..
  42. ncbi Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health
    Ruud Verkerk
    Product Design and Quality Management Group, Wageningen University, Wageningen, The Netherlands
    Mol Nutr Food Res 53:S219. 2009
    b>Glucosinolates (GLSs) are found in Brassica vegetables. Examples of these sources include cabbage, Brussels sprouts, broccoli, cauliflower and various root vegetables (e.g. radish and turnip)...
  43. ncbi Composition and content of glucosinolates in developing Arabidopsis thaliana
    Bent Larsen Petersen
    Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, Frederiksberg C, Copenhagen, Denmark
    Planta 214:562-71. 2002
    ..stems from mature plants with those of green siliques and mature seeds indicated that a majority of the seed glucosinolates were synthesized de novo in the silique...
  44. pmc Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis
    D J Kliebenstein
    Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
    Plant Cell 13:681-93. 2001
    ..We are studying the biosynthesis of glucosinolates, a large group of secondary metabolites, in Arabidopsis to investigate the evolution of enzymes involved in ..
  45. pmc Omics-based approaches to methionine side chain elongation in Arabidopsis: characterization of the genes encoding methylthioalkylmalate isomerase and methylthioalkylmalate dehydrogenase
    Yuji Sawada
    RIKEN Plant Science Center, Yokohama, Kanagawa, Japan
    Plant Cell Physiol 50:1181-90. 2009
    b>Glucosinolates (GSLs) are secondary metabolites in Brassicaceae plants synthesized from amino acids. Methionine-derived GSLs (Met-GSLs) with diverse side chains of various lengths are the major GSLs in Arabidopsis...
  46. ncbi Altered glucosinolate hydrolysis in genetically engineered Arabidopsis thaliana and its influence on the larval development of Spodoptera littoralis
    Meike Burow
    Department of Biochemistry, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knöll Str 8, D 07745, Jena, Germany
    J Chem Ecol 32:2333-49. 2006
    ..g. isothiocyanates, nitriles) formed from the parent glucosinolates upon plant damage...
  47. ncbi Gene expression and glucosinolate accumulation in Arabidopsis thaliana in response to generalist and specialist herbivores of different feeding guilds and the role of defense signaling pathways
    Inga Mewis
    Pennsylvania State University, Department of Entomology, Chemical Ecology Laboratory, State College, PA 16802, USA
    Phytochemistry 67:2450-62. 2006
    ..did not alter aliphatic glucosinolate content in the wild-type, but indole glucosinolates increased slightly...
  48. pmc Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis
    Joachim Schuster
    Molekulare Botanik, Universitat Ulm, 89069 Ulm, Germany
    Plant Cell 18:2664-79. 2006
    ..This suggests that the two pathways have a common evolutionary origin...
  49. ncbi Genes of primary sulfate assimilation are part of the glucosinolate biosynthetic network in Arabidopsis thaliana
    Ruslan Yatusevich
    Botanisches Institut der Universitat zu Koln, Otto Fischer Str 6, D 50674 Köln, Germany
    Plant J 62:1-11. 2010
    b>Glucosinolates are plant secondary metabolites involved in responses to biotic stress. The final step of their synthesis is the transfer of a sulfo group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) onto a desulfo precursor...
  50. pmc A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis
    Ida Elken Sønderby
    Plant Biochemistry Laboratory, Villum Kann Rasmussen Research Centre for Pro Active Plants, and Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, Copenhagen University, 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 153:348-63. 2010
    ..A model for studying R2R3 MYB control of metabolic networks is the glucosinolates (GLSs), secondary metabolites that control plant resistance against insects and pathogens and carry cancer-..
  51. pmc Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide association mapping
    Eva K F Chan
    Department of Plant Sciences, University of California, Davis, California 95616, USA
    Genetics 185:991-1007. 2010
    ....
  52. ncbi Bioinformatic analysis of molecular network of glucosinolate biosynthesis
    Yazhou Chen
    Department of Biology, Genetics Institute, Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, 32610, USA
    Comput Biol Chem 35:10-8. 2011
    b>Glucosinolates constitute a major group of secondary metabolites in Arabidopsis, which play an important role in plant interaction with pathogens and insects. Advances in glucosinolate research have defined the biosynthetic pathways...
  53. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  54. pmc Functional analysis of the tandem-duplicated P450 genes SPS/BUS/CYP79F1 and CYP79F2 in glucosinolate biosynthesis and plant development by Ds transposition-generated double mutants
    Titima Tantikanjana
    Department of Plant Biology and Agronomy, University of California, Davis, California 95616, USA
    Plant Physiol 135:840-8. 2004
    ..This study also provides further demonstration of how gluconisolate biosynthesis, regarded as secondary metabolism, is intricately linked with hormone homeostatis and hence with plant growth and development...
  55. ncbi Arabidopsis IQD1, a novel calmodulin-binding nuclear protein, stimulates glucosinolate accumulation and plant defense
    Maggie Levy
    Department of Plant Sciences, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Plant J 43:79-96. 2005
    b>Glucosinolates are a class of secondary metabolites with important roles in plant defense and human nutrition...
  56. ncbi QTL analysis reveals context-dependent loci for seed glucosinolate trait in the oilseed Brassica juncea: importance of recurrent selection backcross scheme for the identification of 'true' QTL
    N Ramchiary
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    Theor Appl Genet 116:77-85. 2007
    ..the DH populations derived from early to advanced backcrosses revealed a shift in the mean values for various glucosinolates with the advancement of backcrossing, indicating a change in the selective values of the alleles with change ..
  57. pmc UV-B irradiation changes specifically the secondary metabolite profile in broccoli sprouts: induced signaling overlaps with defense response to biotic stressors
    Inga Mewis
    Leibniz Institute of Vegetable and Ornamental Crops Großbeeren Erfurt e V, Department of Quality, Theodor Echtermeyer Weg 1, D 14979 Großbeeren, Germany
    Plant Cell Physiol 53:1546-60. 2012
    ..A new finding is the specific UV-B-mediated induction of glucosinolates (GS), especially of 4-methylsulfinylbutyl GS and 4-methoxy-indol-3-ylmethyl GS, while carotenoids and Chl ..
  58. pmc The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole glucosinolate structures and aphid resistance in Arabidopsis
    Marina Pfalz
    Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
    Plant Cell 21:985-99. 2009
    b>Glucosinolates are defensive secondary compounds that display large structural diversity in Arabidopsis thaliana and related plants...
  59. ncbi Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006
    ..A placebo-controlled, double-blind, randomized clinical study of sprout extracts containing either glucosinolates (principally glucoraphanin, the precursor of sulforaphane) or isothiocyanates (principally sulforaphane) was ..
  60. ncbi A glucosinolate metabolism pathway in living plant cells mediates broad-spectrum antifungal defense
    Pawel Bednarek
    Department of Plant Microbe Interactions, Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 323:101-6. 2009
    ..We identified a metabolic pathway for glucosinolates, known insect deterrents, that differs from the pathway activated by chewing insects...
  61. ncbi Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli
    Shikha Saha
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 56:1906-16. 2012
    ..We compared the bioavailability and metabolism of sulforaphane from portions of lightly cooked fresh or frozen broccoli, and investigated the bioconversion of sulforaphane to erucin...
  62. ncbi Regulation of plant glucosinolate metabolism
    Xiufeng Yan
    College of Life Sciences, Northeast Forestry University, Harbin 150040, China
    Planta 226:1343-52. 2007
    b>Glucosinolates and their degradation products are known to play important roles in plant interaction with herbivores and micro-organisms. In addition, they are important for human life...
  63. pmc The impact of the absence of aliphatic glucosinolates on insect herbivory in Arabidopsis
    Jules Beekwilder
    Plant Research International, Wageningen, The Netherlands
    PLoS ONE 3:e2068. 2008
    Aliphatic glucosinolates are compounds which occur in high concentrations in Arabidopsis thaliana and other Brassicaceae species. They are important for the resistance of the plant to pest insects...
  64. ncbi Molecular mapping of seed aliphatic glucosinolates in Brassica juncea
    T Mahmood
    Department of Agricultural Food and Nutritional Sciences, University of Alberta, Edmonton, Canada
    Genome 46:753-60. 2003
    An RFLP genomic map with 316 loci was used to study the inheritance of aliphatic glucosinolates in Brassica juncea using doubled-haploid (DH) populations developed from a cross between RLM-514, an agronomically superior non-canola quality ..
  65. ncbi CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis
    Sixue Chen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Copenhagen, Denmark
    Plant J 33:923-37. 2003
    Cytochromes P450 of the CYP79 family catalyze the conversion of amino acids to oximes in the biosynthesis of glucosinolates, a group of natural plant products known to be involved in plant defense and as a source of flavor compounds, ..
  66. pmc Decomposers and root feeders interactively affect plant defence in Sinapis alba
    Maité Lohmann
    Institute of Zoology, Darmstadt University of Technology, Schnittspahnstrasse 3, 64287 Darmstadt, Germany
    Oecologia 160:289-98. 2009
    ..Nitrogen-based defence compounds, i.e. glucosinolates, did not correlate with nitrogen levels...
  67. ncbi The effect of temperature, photoperiod, and light quality on gluconasturtiin concentration in watercress (Nasturtium officinale R. Br.)
    Gerard Engelen-Eigles
    Department of Horticultural Science, University of Minnesota, 1970 Folwell Avenue, 305 Alderman Hall, St Paul, Minnesota 55108, USA
    J Agric Food Chem 54:328-34. 2006
    ..These data indicate that the concentration of gluconasturtiin in watercress can be significantly increased by growing plants at lower temperatures, under long days, and by exposure to R light...
  68. ncbi Exogenous glucosinolate produced by Arabidopsis thaliana has an impact on microbes in the rhizosphere and plant roots
    Mélanie Bressan
    Lab Ecol Microb Rhizosphere and Environ Extrem LEMiRE, Saint Paul lez Durance, France
    ISME J 3:1243-57. 2009
    A specificity of Brassicaceous plants is the production of sulphur secondary metabolites called glucosinolates that can be hydrolysed into glucose and biocidal products...
  69. pmc Proposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds
    John W Finley
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    Ann Bot 95:1075-96. 2005
    ..The 'functional food' industry has produced and marketed foods enriched with bioactive compounds, but there are no universally accepted criteria for judging efficacy of the compounds or enriched foods...
  70. ncbi An ecological genomic approach challenging the paradigm of differential plant responses to specialist versus generalist insect herbivores
    M Gabriela Bidart-Bouzat
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43402, USA
    Oecologia 167:677-89. 2011
    ..of herbivore-induced changes in genome-wide gene expression, defense-related pathways, and concentrations of glucosinolates (i.e., secondary metabolites that are ubiquitously present in cruciferous plants)...
  71. ncbi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011
    ..Reduction in APS kinase activity led to reduced levels of glucosinolates as a major class of sulfated secondary metabolites and an increased concentration of thiols, products of ..
  72. ncbi A redox-active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis
    Yan He
    Department of Biology, Genetics Institute, Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32610, USA
    Plant J 60:679-90. 2009
    ..Mutation of AtIPMDH1 leads to a significant reduction in the levels of free leucine and of glucosinolates with side chains of four or more carbons...
  73. pmc Indole-3-acetonitrile production from indole glucosinolates deters oviposition by Pieris rapae
    Martin De Vos
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Plant Physiol 146:916-26. 2008
    Like many crucifer-specialist herbivores, Pieris rapae uses the presence of glucosinolates as a signal for oviposition and larval feeding...
  74. ncbi The three desulfoglucosinolate sulfotransferase proteins in Arabidopsis have different substrate specificities and are differentially expressed
    Marion Klein
    Institute for Botany, University of Hannover, Germany
    FEBS J 273:122-36. 2006
    ..High (500 microM) and low (50 microM) sulfate concentrations in the medium did not influence the levels of expression...
  75. ncbi Effects of glucosinolates and their enzymatic hydrolysis products via myrosinase on the root-knot nematode Meloidogyne incognita (Kofoid et White) Chitw
    Luca Lazzeri
    Research Institute for Industrial Crops, Italian Ministry of Agricultural and Forestry Politics, Via di Corticella 133, 40129 Bologna, Italy
    J Agric Food Chem 52:6703-7. 2004
    ..The aim of this study was to evaluate, in vitro, the biocidal activity of 11 glucosinolates and their degradation products on second-stage juveniles of the root-knot nematode M...
  76. pmc The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis
    Meike Burow
    Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Plant Physiol 149:561-74. 2009
    b>Glucosinolates are a group of thioglucosides that are components of an activated chemical defense found in the Brassicales. Plant tissue damage results in hydrolysis of glucosinolates by endogenous thioglucosidases known as myrosinases...
  77. pmc Subclade of flavin-monooxygenases involved in aliphatic glucosinolate biosynthesis
    Jing Li
    Plant Biochemistry Laboratory, Department of Plant Biology and Villum Kann Rasmussen Research Centre for Pro Active Plants, Faculty of Life Sciences, University of Copenhagen, DK 1871 Frederiksberg C, Denmark
    Plant Physiol 148:1721-33. 2008
    b>Glucosinolates (GSLs) are amino acid-derived secondary metabolites with diverse biological activities dependent on chemical modifications of the side chain...
  78. pmc Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Pharmacol Res 55:224-36. 2007
    Cruciferous vegetables are a rich source of glucosinolates and their hydrolysis products, including indoles and isothiocyanates, and high intake of cruciferous vegetables has been associated with lower risk of lung and colorectal cancer ..
  79. pmc Nitrile-specifier proteins involved in glucosinolate hydrolysis in Arabidopsis thaliana
    Ralph Kissen
    Department of Biology, Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
    J Biol Chem 284:12057-70. 2009
    b>Glucosinolates are plant secondary metabolites present in Brassicaceae plants such as the model plant Arabidopsis thaliana...
  80. pmc Genotype, age, tissue, and environment regulate the structural outcome of glucosinolate activation
    Adam M Wentzell
    Genetics Graduate Group and Department of Plant Sciences, University of California, Davis, Davis, CA 95616, USA
    Plant Physiol 147:415-28. 2008
    b>Glucosinolates are the inert storage form of a two-part phytochemical defense system in which the enzyme myrosinase generates an unstable intermediate that rapidly rearranges into the biologically active product...
  81. ncbi Ontogenetic changes of 2-propenyl and 3-indolylmethyl glucosinolates in Brassica carinata leaves as affected by water supply
    Monika Schreiner
    Department of Quality Research, Leibniz Institute of Vegetable and Ornamental Crops Grossbeeren and Erfurt e V, Theodor Echtermeyer Weg 1, Grossbeeren, Germany
    J Agric Food Chem 57:7259-63. 2009
    Concentrations of 2-propenyl and 3-indolylmethyl glucosinolates in two lines of Brassica carinata (Holeta-1 and 37-A) were assessed during the vegetative life cycle under optimal or drought-inducing water supply conditions...
  82. ncbi Impact of nitrogen and sulfur fertilization on the composition of glucosinolates in relation to sulfur assimilation in different plant organs of broccoli
    Michalis D Omirou
    Agricultural University of Athens, Department of Natural Resources and Agricultural Engineering, Laboratory of Soils and Agricultural Chemistry, 75 Iera Odos Street, 11855 Athens, Greece
    J Agric Food Chem 57:9408-17. 2009
    ..one of the most important winter season vegetables and a rich source of chemoprotective molecules, including glucosinolates (GSL)...
  83. ncbi Glucosinolate biochemical diversity and innovation in the Brassicales
    Richard Mithen
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
    Phytochemistry 71:2074-86. 2010
    b>Glucosinolates were analysed from herbarium specimens and living tissues from representative of all families of the Brassicales, following the phylogenetic schemes of Rodman et al. (1998) and Hall et al...
  84. ncbi Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli
    Rebecca J Robbins
    Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, East Beltsville, Maryland, USA
    J Med Food 8:204-14. 2005
    ..The health benefits of broccoli are partly associated with secondary plant compounds that have bioactivity; glucosinolates and phenolic acids are two of the most abundant and important in broccoli...
  85. ncbi UVR8 mediates UV-B-induced Arabidopsis defense responses against Botrytis cinerea by controlling sinapate accumulation
    Patricia V Demkura
    IFEVA, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos Aires, Ave San Martín 4453, C1417DSE, Buenos Aires, Argentina
    Mol Plant 5:642-52. 2012
    ..pad3-1, pen2 pad3), suggesting that neither regulation of the JA pathway nor changes in levels of indolic glucosinolates (iGS) or camalexin are involved in this response...
  86. ncbi Role of camalexin, indole glucosinolates, and side chain modification of glucosinolate-derived isothiocyanates in defense of Arabidopsis against Sclerotinia sclerotiorum
    Henrik U Stotz
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Plant J 67:81-93. 2011
    ..the myb28 mutant, which has a regulatory defect resulting in decreased production of long-chained aliphatic glucosinolates. The antimicrobial activity of aliphatic glucosinolate-derived isothiocyanates was dependent on side chain ..
  87. pmc Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation
    Tanja Knill
    Institut Molekulare Botanik, Universitat Ulm, Albert Einstein Allee 11, 89069 Ulm, Germany
    Plant Mol Biol 71:227-39. 2009
    ..of intermediates of both Leu biosynthesis and Met chain elongation, and an altered composition of aliphatic glucosinolates demonstrating the function of this gene in both pathways...
  88. ncbi The enzymic and chemically induced decomposition of glucosinolates
    Atle M Bones
    Department of Biology, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    Phytochemistry 67:1053-67. 2006
    ..years by a number of authors, little attention has been paid to the enzymic and non-enzymic degradation of glucosinolates. Non-enzymic degradation processes are particularly important in the processing of brassica vegetables with ..
  89. ncbi Accumulation of glucosinolates by the cabbage aphid Brevicoryne brassicae as a defense against two coccinellid species
    Corin Pratt
    Division of Biology, Faculty of Natural Sciences, Imperial College London, Wye Campus, Ashford, Kent, TN25 5AH, UK
    J Chem Ecol 34:323-9. 2008
    ..bipunctata but not for C. septempunctata, although for this ladybird species, there appear to be costs associated with feeding on aphids that contain this secondary metabolite...
  90. ncbi Tipping the scales--specifier proteins in glucosinolate hydrolysis
    Ute Wittstock
    Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig, Braunschweig, Germany
    IUBMB Life 59:744-51. 2007
    b>Glucosinolates are a group of secondary plant metabolites found in the Brassicales order that are beneficial components of our diet, determine the flavor of a number of vegetables and spices and have been implicated in pest management ..
  91. pmc Tri-trophic effects of inter- and intra-population variation in defence chemistry of wild cabbage (Brassica oleracea)
    Jeffrey A Harvey
    Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands
    Oecologia 166:421-31. 2011
    ..Insect performance and chemical profiles were made from every plant used in the experiment. Foliar glucosinolates (GS) concentrations were highest in the wild plants in rank order WIN > OH > KIM, with lower levels ..
  92. ncbi Phytochemicals of Brassicaceae in plant protection and human health--influences of climate, environment and agronomic practice
    Maria Bjorkman
    Norwegian Institute for Agricultural and Environmental Research Bioforsk, Plant Health and Plant Protection Division, Høgskoleveien 7, N 1432 Ås, Norway
    Phytochemistry 72:538-56. 2011
    In this review, we provide an overview of the role of glucosinolates and other phytochemical compounds present in the Brassicaceae in relation to plant protection and human health...
  93. ncbi Glucosinolate polymorphism in wild cabbage (Brassica oleracea) influences the structure of herbivore communities
    Erika L Newton
    Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Tremough, Penryn, Cornwall, UK
    Oecologia 160:63-76. 2009
    ..Brassica oleracea (Brassicaceae) produces aliphatic glucosinolates, which break down into toxins when leaf tissue is damaged...
  94. ncbi Evolution of nitrilases in glucosinolate-containing plants
    Tim Janowitz
    Department of Plant Physiology, Ruhr Universitat Bochum, Bochum, Germany
    Phytochemistry 70:1680-6. 2009
    ..rather broad substrate specificities and are able to hydrolyze nitriles that result from the decomposition of glucosinolates, the typical secondary metabolites of the Brassicaceae...
  95. ncbi Sequestration of glucosinolates and iridoid glucosides in sawfly species of the genus Athalia and their role in defense against ants
    Sebastian E W Opitz
    Department of Chemical Ecology, Bielefeld University, Universitatsstr 25, 33615, Bielefeld, Germany
    J Chem Ecol 36:148-57. 2010
    ..Brassicaceae are characterized by glucosinolates (GLSs), whereas Plantaginaceae contain iridoid glucosides (IGs) as characteristic secondary compounds...
  96. pmc Arabidopsis bile acid:sodium symporter family protein 5 is involved in methionine-derived glucosinolate biosynthesis
    Yuji Sawada
    RIKEN Plant Science Center, Yokohama, Kanagawa, Japan
    Plant Cell Physiol 50:1579-86. 2009
    b>Glucosinolates (GSLs) are a group of plant secondary metabolites that have repellent activity against herbivore insects and pathogens, and anti-carcinogenic activity in humans...
  97. pmc A novel 2-oxoacid-dependent dioxygenase involved in the formation of the goiterogenic 2-hydroxybut-3-enyl glucosinolate and generalist insect resistance in Arabidopsis,
    Bjarne G Hansen
    Plant Biochemistry Laboratory, Department of Plant Biology, VKR Centre for Pro Active Plants, Faculty of Life Sciences, University of Copenhagen, DK 1871 Frederiksberg C, Denmark
    Plant Physiol 148:2096-108. 2008
    b>Glucosinolates are secondary metabolites found almost exclusively in the order Brassicales. They are synthesized from a variety of amino acids and can have numerous side chain modifications that control biological function...
  98. pmc Barbarea vulgaris glucosinolate phenotypes differentially affect performance and preference of two different species of lepidopteran herbivores
    Hanneke van Leur
    Department of Multitrophic Interactions, Netherlands Institute of Ecology NIOO KNAW, Centre for Terrestrial Ecology, Heteren, The Netherlands
    J Chem Ecol 34:121-31. 2008
    ..Because of the structural differences, these glucosinolates may have different effects on herbivores...
  99. ncbi Mutual feedbacks maintain both genetic and species diversity in a plant community
    Richard A Lankau
    Section of Evolution and Ecology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Science 317:1561-3. 2007
    ..nigra. Thus, conservation of species diversity may also necessitate maintenance of the processes that sustain the genetic diversity of each individual species...
  100. pmc Performance of generalist and specialist herbivores and their endoparasitoids differs on cultivated and wild Brassica populations
    Rieta Gols
    Laboratory of Entomology, Plant Science Group, Wageningen University, Wageningen, The Netherlands
    J Chem Ecol 34:132-43. 2008
    ..Plants in the Brassicaceae characteristically produce defense-related glucosinolates (GS)...
  101. ncbi Specialist and generalist herbivores exert opposing selection on a chemical defense
    Richard A Lankau
    Section of Evolution and Ecology, University of California Davis, Davis, CA 95616, USA
    New Phytol 175:176-84. 2007
    ....

Research Grants35

  1. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
    ..Isothiocyanates (ITC), the bioactive components derived from glucosinolates in cruciferous vegetables, have been shown to modulate enzymes that metabolize exogenous compounds (e.g...
  2. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2013
    ..high consumption of Brassica vegetables and the incidence of lung cancer;(2) The high concentration of indole glucosinolates, the parent compounds for I3C, in Brassica vegetables;(3) Cancer preventive activity of I3C in in vitro and in ..
  3. GENETIC ANALYSIS OF THE PLANT DEFENSE RESPONSE
    Frederick M Ausubel; Fiscal Year: 2013
    ..via a pathway that involves the transcription factor MYB51, ethylene signaling, and the synthesis of indole glucosinolates that function as novel secondary messengers...
  4. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..In particular, specific chemical components of the diet, such as flavonoids, isocyanates, glucosinolates, indoles, dithiolthiones, and polyphenols have been identified as effective inducers and/or inhibitors of ..
  5. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..Phytochemicals such as phenols, flavonoids, isoflavones, terpenes and glucosinolates have anti-oxidant and anti-carcinogenic properties and demonstrate a wide spectrum of tumor-blocking ..
  6. Liberation of Plant Nutrients by the Gut Microbiota
    ELIZABETH SUSAN SATTELY; Fiscal Year: 2013
    ..g. anti-inflammatory isoflavonoids and chemo preventative glucosinolates)...
  7. Molecular causes and fitness consequences of complex trait variation
    STORRS THOMAS MITCHELL-OLDS; Fiscal Year: 2013
    ..In addition, these experiments examine the genetics of glucosinolates, which are a focus of biomedical research due to their role in prevention of many forms of cancer, as well as ..
  8. MECHANISMS OF CHAIN ELONGATION OF ALPHA-KETO ACIDS
    Carl Stevens; Fiscal Year: 1980
    ..of the biosynthesis of a variety of amino acids which are immediate precursors of the mustard oil glucosides (glucosinolates) occurring in the Cruciferae and other plants...
  9. Dietary Intervention in the Gallus Domesticus Model of Ovarian Cancer
    DALE HALES; Fiscal Year: 2009
    ..Cruciferous vegetables such as broccoli contain a vast array of potentially bioactive compounds, including glucosinolates that can be hydrolyzed to metabolites with known anticarcinogenic activity, particularly sulforaphane and ..
  10. NOVEL STRATEGIES FOR CHEMOPROTECTION AGAINST CANCER
    Paul Talalay; Fiscal Year: 2000
    ..The capacity of humans to degrade glucosinolates to isothiocyanates will also be measured. In Project No.3 (T.W...
  11. Development of New GI-specific Histone Deacetylase Inhi*
    Scott Rajski; Fiscal Year: 2006
    ..associated not only with broccoli consumption but also the ingestion of many other vegetables that provide glucosinolates capable of GI-localized metabolism as shown below...
  12. Diet and Genetic Risks for Prostate Cancer
    Marian Neuhouser; Fiscal Year: 2005
    ..g., lycopene, glucosinolates) decrease risk...
  13. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..
  14. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  15. Protection by Induction of Ubiquitin-Proteasome Systems
    Thomas Kensler; Fiscal Year: 2005
    ....
  16. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..information on the safety, metabolism and urinary disposition of isothiocyanates, and on the activation of glucosinolates. Since it is possible to grow broccoli sprouts with a consistent composition of glucoraphanin, we propose to ..
  17. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  18. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  19. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  21. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  22. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  23. Topoisomerases: Target for Antitrypanosomal Therapy
    Theresa Shapiro; Fiscal Year: 2006
    ..Compounds that appear most promising will be evaluated in mice. These studies take a multi-faceted, rational, and tangible approach to the development of much-needed new anti-trypanosomal chemotherapy. ..
  24. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  25. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  26. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  27. An Exploratory Center for Obesity Research (RMI)
    Adam Drewnowski; Fiscal Year: 2006
    ..By promoting interagency collaborations, these efforts will help the NIH develop a roadmap on how to effectively translate research findings into national, state, and local health policy. [unreadable] [unreadable]..
  28. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  29. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  30. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  31. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  32. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  33. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  34. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..