mannitol

Summary

Summary: A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Top Publications

  1. pmc Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51
    Yimin Wu
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
    PLoS ONE 3:e2636. 2008
  2. pmc Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes
    Zhulong Chan
    Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, PR China
    J Exp Bot 62:4787-803. 2011
  3. pmc Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain
    Nikisha Carty
    Byrd Alzheimer s Institute and Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33613, USA
    J Neurosci Methods 194:144-53. 2010
  4. ncbi Salt-regulated mannitol metabolism in algae
    Koji Iwamoto
    Functional Biosciences, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Mar Biotechnol (NY) 7:407-15. 2005
  5. pmc Mannitol is required for stress tolerance in Aspergillus niger conidiospores
    George J G Ruijter
    Section of Molecular Genetics of Industrial Microorganisms, Wageningen University, 6703HA Wageningen, The Netherlands
    Eukaryot Cell 2:690-8. 2003
  6. ncbi A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery
    Ching Tang Wu
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, 325 Section 2, Chenggung Rd, Neihu 114, Taipei, Taiwan
    Anesth Analg 110:903-7. 2010
  7. ncbi The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporus
    S Hörer
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, 3012 Berne, Switzerland
    J Biol Chem 276:27555-61. 2001
  8. ncbi Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion
    Corinna Burger
    Department of Molecular Genetics and Microbiology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Ther 11:327-31. 2005
  9. pmc The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
    John D Brannan
    Department of Respiratory Medicine, 11 West, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Respir Res 6:144. 2005
  10. ncbi Effects of contrast media and mannitol on renal medullary blood flow and red cell aggregation in the rat kidney
    P Liss
    Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden
    Kidney Int 49:1268-75. 1996

Detail Information

Publications276 found, 100 shown here

  1. pmc Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51
    Yimin Wu
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
    PLoS ONE 3:e2636. 2008
    ..This single blinded, dose escalating, controlled Phase 1 study assessed the safety and immunogenicity of recombinant Pfs25 and Pvs25 formulated with Montanide ISA 51, a water-in-oil emulsion...
  2. pmc Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes
    Zhulong Chan
    Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, PR China
    J Exp Bot 62:4787-803. 2011
    b>Mannitol is a putative osmoprotectant contributing to salt tolerance in several species...
  3. pmc Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain
    Nikisha Carty
    Byrd Alzheimer s Institute and Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33613, USA
    J Neurosci Methods 194:144-53. 2010
    ..Systemic mannitol administration, which reduces intracranial pressure, also further expanded distribution of GFP expression, in ..
  4. ncbi Salt-regulated mannitol metabolism in algae
    Koji Iwamoto
    Functional Biosciences, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Mar Biotechnol (NY) 7:407-15. 2005
    b>Mannitol, one of the most widely occurring sugar alcohol compounds, is found in bacteria, fungi, algae, and plants...
  5. pmc Mannitol is required for stress tolerance in Aspergillus niger conidiospores
    George J G Ruijter
    Section of Molecular Genetics of Industrial Microorganisms, Wageningen University, 6703HA Wageningen, The Netherlands
    Eukaryot Cell 2:690-8. 2003
    D-Mannitol is the predominant carbon compound in conidiospores of the filamentous fungus Aspergillus niger and makes up 10 to 15% of the dry weight...
  6. ncbi A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery
    Ching Tang Wu
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, 325 Section 2, Chenggung Rd, Neihu 114, Taipei, Taiwan
    Anesth Analg 110:903-7. 2010
    In this study, we compared the effects of 3% hypertonic saline (HTS) and 20% mannitol on brain relaxation during supratentorial brain tumor surgery, intensive care unit (ICU) stays, and hospital days.
  7. ncbi The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporus
    S Hörer
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, 3012 Berne, Switzerland
    J Biol Chem 276:27555-61. 2001
    b>Mannitol, an acyclic six-carbon polyol, is one of the most abundant sugar alcohols occurring in nature...
  8. ncbi Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion
    Corinna Burger
    Department of Molecular Genetics and Microbiology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Ther 11:327-31. 2005
    ..In the present study, we reexamined the effects of both local and systemic administration of mannitol-induced hyperosmolality on facilitation of transgene expression and vector distribution in the CNS...
  9. pmc The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
    John D Brannan
    Department of Respiratory Medicine, 11 West, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Respir Res 6:144. 2005
    Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing...
  10. ncbi Effects of contrast media and mannitol on renal medullary blood flow and red cell aggregation in the rat kidney
    P Liss
    Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden
    Kidney Int 49:1268-75. 1996
    ..In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 ..
  11. ncbi Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro
    Ana Grenha
    University of Santiago de Compostela, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, 15782 Santiago de Compostela, Spain
    Eur J Pharm Sci 31:73-84. 2007
    ..was to evaluate the biocompatibility of novel respirable powder formulations of nanoparticles (NP) entrapped in mannitol microspheres using human respiratory epithelial cell lines...
  12. ncbi Proof of principle: hydration by low-osmolar mannitol-glucose solution alleviates undesirable renal effects of an iso-osmolar contrast medium in rats
    Erdmann Seeliger
    Institute of Physiology, Center for Cardiovascular Research, Charite Universitatsmedizin Berlin, CCM, Berlin, Germany
    Invest Radiol 47:240-6. 2012
    ..Osmodiuretics have a stronger diuretic effect than saline, yet previous trials indicate that osmodiuretic mannitol tends to promote rather than to prevent CM-induced acute kidney injury...
  13. ncbi Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials
    Hooman Kamel
    Department of Neurology, University of California, San Francisco, CA, USA
    Crit Care Med 39:554-9. 2011
    Randomized trials have suggested that hypertonic saline solutions may be superior to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical practice has been limited, partly by their small size...
  14. ncbi Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO
    Celeste Porsbjerg
    Respiratory and Allergy Research Unit, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, NV, Denmark
    J Asthma 46:606-12. 2009
    ..adult non-smoking asthmatics, (18-65 yr) not taking inhaled steroids, sputum induction, bronchial challenge with mannitol and measurement of exhaled NO (eNO) were performed...
  15. ncbi Recent advances in the biological production of mannitol
    Seung Hoon Song
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 4320, USA
    Appl Microbiol Biotechnol 84:55-62. 2009
    b>Mannitol is a fructose-derived, 6-carbon sugar alcohol that is widely found in bacteria, yeasts, fungi, and plants...
  16. ncbi Constitutive expression of a celery mannitol dehydrogenase in tobacco enhances resistance to the mannitol-secreting fungal pathogen Alternaria alternata
    Dianne B Jennings
    Department of Horticultural Science, North Carolina State University, Raleigh NC 27695, USA
    Plant J 32:41-9. 2002
    Our previous observation that host plant extracts induce production and secretion of mannitol in the tobacco pathogen Alternaria alternata suggested that, like their animal counterparts, plant pathogenic fungi might produce the reactive ..
  17. ncbi Comprehensive expression profiling analysis of OsIAA gene family in developmental processes and in response to phytohormone and stress treatments
    Yaling Song
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070, Wuhan, China
    Planta 229:577-91. 2009
    ..plant growth and auxin distribution was further confirmed with the root growth of DR5-GUS transgenic rice under mannitol treatment, in which a close association between mannitol-induced changes of auxin distribution and root growth ..
  18. ncbi Decoding the mannitol enigma in filamentous fungi
    Peter S Solomon
    Australian Centre for Necrotrophic Fungal Pathogens, SABC, Division of Health Sciences, Murdoch University, Perth, WA 6150, Australia
    Trends Microbiol 15:257-62. 2007
    b>Mannitol is a 6-carbon polyol that is among the most abundant biochemical compounds in the biosphere...
  19. pmc Tolerance of mannitol-accumulating transgenic wheat to water stress and salinity
    Tilahun Abebe
    Department of Plant and Soil Sciences, Oklahoma State University, Stillwater 74078, USA
    Plant Physiol 131:1748-55. 2003
    Previous work with model transgenic plants has demonstrated that cellular accumulation of mannitol can alleviate abiotic stress...
  20. pmc Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults
    Mark A Pierce
    Malaria Vaccine Development Branch MVDB, National Institute of Allergy and Infectious Disease, National Institutes of Health NIAID NIH, Rockville, MD 20852, United States
    Vaccine 28:2236-42. 2010
    ..AMA1-C1 formulated in ISA 720 is immunogenic in malaria-naïve Australian adults. It is reasonably tolerated, though some transient, severe, and late local reactions are seen...
  21. ncbi Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications
    S I Rapoport
    Section on Brain Physiology and Metabolism, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Mol Neurobiol 20:217-30. 2000
    1. Osmotic opening of the blood-brain barrier by intracarotid infusion of a hypertonic arabinose or mannitol solution is mediated by vasodilatation and shrinkage of cerebrovascular endothelial cells, with widening of the interendothelial ..
  22. ncbi Immunogenicity and protective efficacy of recombinant vaccine based on the receptor-binding domain of the Plasmodium vivax Duffy binding protein in Aotus monkeys
    Myriam Arevalo-Herrera
    Institute of Immunology, Universidad del Valle, Cali, Colombia
    Am J Trop Med Hyg 73:25-31. 2005
    ..Given the immunogenicity and partial protection observed, further studies are needed to optimize the PvRII vaccine formulation with adjuvants suitable for human use...
  23. ncbi Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California, USA
    J Trauma 56:1191-6. 2004
    The combination of bicarbonate and mannitol (BIC/MAN) is commonly used to prevent renal failure (RF) in patients with rhabdomyolysis despite the absence of sufficient evidence validating its use...
  24. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
    Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is uncertain.
  25. ncbi Effect of equiosmolar solutions of mannitol versus hypertonic saline on intraoperative brain relaxation and electrolyte balance
    Irene Rozet
    Department of Anesthesiology, Harborview Medical Center, University of Washington, Seattle 98104, USA
    Anesthesiology 107:697-704. 2007
    The purpose of the study was to compare the effect of equiosmolar solutions of mannitol and hypertonic saline (HS) on brain relaxation and electrolyte balance.
  26. ncbi Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy
    Susan L Bratton
    J Neurotrauma 24:S14-20. 2007
  27. ncbi Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    J Cell Mol Med 14:914-21. 2010
    We recently demonstrated that blood-brain barrier permeabilization using mannitol enhances the therapeutic efficacy of systemically administered human umbilical cord blood (HUCB) by facilitating the entry of neurotrophic factors from the ..
  28. ncbi Provocative challenges to help diagnose and monitor asthma: exercise, methacholine, adenosine, and mannitol
    Sandra D Anderson
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Curr Opin Pulm Med 14:39-45. 2008
    ..To review bronchial provocations tests used in the measurement of bronchial hyperresponsiveness to help in the diagnosis of asthma...
  29. ncbi Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain
    Kuen Bao Chen
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Neuroreport 24:303-7. 2013
    Intravenous mannitol (IV-M) is widely administered in the clinic to lower intracranial pressure in patients with brain trauma and stroke...
  30. ncbi A comparison of two doses of mannitol on brain relaxation during supratentorial brain tumor craniotomy: a randomized trial
    Charlotte Quentin
    Department of Anesthesiology, Montreal University Medical Centre, Montreal, Quebec, Canada
    Anesth Analg 116:862-8. 2013
    Twenty percent mannitol is widely used to reduce brain bulk and facilitate the surgical approach in intracranial surgery. However, a dose-response relationship has not yet been established. In this study, we compared the effects of 0...
  31. ncbi Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis
    Diana Bilton
    Royal Brompton Hospital, London, United Kingdom
    J Cyst Fibros 12:367-76. 2013
    To evaluate safety and efficacy of inhaled mannitol treatment in subgroups of a large global CF population.
  32. pmc Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol
    Ludwika Tomaszewska
    Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37 41, 51 630 Wrocław, Poland
    J Ind Microbiol Biotechnol 39:1333-43. 2012
    ..This study presents an alternative means of crude glycerol valorization through the production of erythritol and mannitol. In a shake-flasks experiment in a buffered medium, nine Yarrowia lipolytica strains were examined for polyols ..
  33. ncbi The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea
    E Placidi
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, UK
    Aliment Pharmacol Ther 36:64-73. 2012
    ..Novel MRI techniques to assess small bowel water content (SBWC) have shown that mannitol solutions markedly increase SBWC and can be used as a model of diarrhoea.
  34. pmc Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis
    Yu Yo Sun
    Division of Developmental Biology, Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
    J Neurosci Methods 203:122-9. 2012
    ..Here we report an in vivo TTC perfusion-labeling method based on osmotic opening of blood-brain-barrier with mannitol-pretreatment...
  35. ncbi CpG oligodeoxynucleotide and montanide ISA 206 adjuvant combination augments the immune responses of a recombinant FMDV vaccine in cattle
    Jiling Ren
    Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China
    Vaccine 29:7960-5. 2011
    ..These findings suggest that CpG ODN RW03 could be used with Montanide ISA 206 as a potent adjuvant for recombinant FMDV in cattle...
  36. pmc High yields of 2,3-butanediol and mannitol in Lactococcus lactis through engineering of NAD⁺ cofactor recycling
    Paula Gaspar
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av Republica EAN, 2780 157 Oeiras, Portugal
    Appl Environ Microbiol 77:6826-35. 2011
    ..The three lactate dehydrogenase-deficient mutants were selected as a background for the production of mannitol and 2,3-butanediol...
  37. pmc Cloning and characterization of NADP-mannitol dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress
    J M Stoop
    Department of Industrial Agrobiotechnology, Agrotechnological Research Institute, NL 6700 AA Wageningen, The Netherlands
    Appl Environ Microbiol 64:4689-96. 1998
    b>Mannitol, a six-carbon sugar alcohol, is the main storage carbon in the button mushroom, Agaricus bisporus. Given the physiological importance of mannitol metabolism in growth, fruit body development, and salt tolerance of A...
  38. ncbi Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage
    Pan Yu
    Department of Plastic and Reconstructive Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Biochem Biophys Res Commun 409:350-5. 2011
    ..The results revealed that both mannitol and high glucose could cause oxidative stress in HSFs...
  39. ncbi Mannitol opening of the blood-brain barrier: regional variation in the permeability of sucrose, but not 86Rb+ or albumin
    Rachel C Brown
    Department of Pharmacology, The University of Arizona, College of Medicine, PO Box 24 5050, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Brain Res 1014:221-7. 2004
    ..86Rb+ and [14C]sucrose had increased permeability 20 min after BBB disruption with 1.6 M mannitol. There was no change in Evans blue albumin permeability...
  40. ncbi Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses
    Hongmiao Song
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 100093, Beijing, China
    Planta 229:955-64. 2009
    ....
  41. ncbi The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction
    M N A Smith
    Department of Anaesthesia, Wessex Cardiothoracic Centre, South Hampton General Hospital, Southampton, UK
    Anaesthesia 63:701-4. 2008
    The usefulness of mannitol in the priming fluid for cardiopulmonary bypass is uncertain in patients with normal renal function, and has not been studied in patients with established renal dysfunction...
  42. pmc Spatial and developmental differentiation of mannitol dehydrogenase and mannitol-1-phosphate dehydrogenase in Aspergillus niger
    Guillermo Aguilar-Osorio
    Fungal Physiology, CBS KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Eukaryot Cell 9:1398-402. 2010
    The presence of a mannitol cycle in fungi has been subject to discussion for many years. Recent studies have found no evidence for the presence of this cycle and its putative role in regenerating NADPH...
  43. ncbi Combined injection of rAAV with mannitol enhances gene expression in the rat brain
    M Y Mastakov
    Functional Genomics and Translational Neuroscience Laboratory, Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Mol Ther 3:225-32. 2001
    ..Moreover, we evaluated the effect of local administration of mannitol to further enhance transgene expression and vector spread. Ultraslow microperfusion of rAAV, i.e...
  44. ncbi The effect of phlebotomy and mannitol on acute renal injury induced by ischemia/reperfusion of lower limbs in rats
    Ibrahim Goksin
    Department of Cardiovascular Surgery, School of Medicine, Pamukkale University, Denizli, Turkey
    Ann Vasc Surg 25:1118-28. 2011
    ..Venous blood volume exclusion from the inferior vena cava (phlebotomy) or/and mannitol are used as a treatment for I/R injury of kidney in humans, despite the fact that the effectiveness of these ..
  45. pmc Mannitol is required for asexual sporulation in the wheat pathogen Stagonospora nodorum (glume blotch)
    Peter S Solomon
    Australian Centre for Necrotrophic Fungal Pathogens, SABC, Division of Health Sciences, Murdoch University, Perth 6150, WA, Australia
    Biochem J 399:231-9. 2006
    The physiological role of the mannitol cycle in the wheat pathogen Stagonospora nodorum (glume blotch) has been investigated by reverse genetics and metabolite profiling...
  46. ncbi Long-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study
    Moira L Aitken
    University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 185:645-52. 2012
    ..New treatment strategies are needed to improve airway clearance and reduce the morbidity and the time burden associated with cystic fibrosis (CF)...
  47. ncbi Lactulose/mannitol test and specificity, sensitivity, and area under curve of intestinal permeability parameters in patients with liver cirrhosis and Crohn's disease
    Milan Dastych
    Department of Clinical Biochemistry and Hematology, University Hospital Brno, Jihlavska 20, 62500, Brno, Czech Republic
    Dig Dis Sci 53:2789-92. 2008
    ..study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability ..
  48. ncbi Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24 h of cold ischemia
    Sebastian P Sommer
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, 30623 Hannover, Germany
    Eur J Cardiothorac Surg 26:151-7. 2004
    ..The purpose of the study was to compare two extracellular type solutions, low potassium dextrane (LPD) and Celsior in their ability of ameliorating lung ischemia reperfusion injury...
  49. ncbi Montanide™ ISA 71 VG adjuvant enhances antibody and cell-mediated immune responses to profilin subunit antigen vaccination and promotes protection against Eimeria acervulina and Eimeria tenella
    Seung I Jang
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA
    Exp Parasitol 127:178-83. 2011
    ..These results demonstrate that the recombinant profilin subunit vaccine, when given in combination with Montanide™ ISA 71 VG, augments protective immunity against E. acervulina and E. tenella...
  50. ncbi Bowel magnetic resonance imaging of pediatric patients with oral mannitol MRI compared to endoscopy and intestinal ultrasound
    Arne S Borthne
    Department of Pediatric Radiology, Ullevaal University Hospital, Kirkeveien 166, 0407, Oslo, Norway
    Eur Radiol 16:207-14. 2006
    ..A median volume of 300 ml of mannitol in a 15% [corrected] watery solution were ingested by 43 children prior to examination...
  51. ncbi Dry powder aerosols generated by standardized entrainment tubes from alternative sugar blends: 3. Trehalose dihydrate and D-mannitol carriers
    Heidi M Mansour
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 7360, USA
    J Pharm Sci 99:3430-41. 2010
    ..The two carrier sugars, each representing a different sugar class, were D-mannitol and trehalose dihydrate...
  52. ncbi Mannitol dry powder challenge in comparison with exercise testing in children
    Juerg Barben
    Division of Paediatric Pulmonology, Children s Hospital, St Gallen, Switzerland
    Pediatr Pulmonol 46:842-8. 2011
    b>Mannitol dry powder (MDP) challenge is an indirect bronchial provocation test, which is well studied in adults but not established for children.
  53. pmc Airway hyperresponsiveness to methacholine, adenosine 5-monophosphate, mannitol, eucapnic voluntary hyperpnoea and field exercise challenge in elite cross-country skiers
    Malcolm Sue-Chu
    Department of Lung Medicine, St Olavs Hospital, University Hospital of Trondheim, N 7006 Trondheim, Norway
    Br J Sports Med 44:827-32. 2010
    ..This study investigated airway responsiveness to these stimuli as well as to adenosine 5'-monophosphate (AMP) and mannitol, in 58 cross-country ski athletes.
  54. ncbi Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice
    D M McCarty
    The Center for Gene Therapy, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43205, USA
    Gene Ther 16:1340-52. 2009
    ..Earlier, we showed a global central nervous system (CNS) transduction in mice by mannitol-facilitated entry of intravenous (IV)-delivered recombinant adeno-associated viral serotype 2 (rAAV2) vector...
  55. ncbi Cut-points for response to mannitol challenges using the forced oscillation technique
    Melissa A McClean
    Woolcock Institute of Medical Research, Glebe, NSW, Australia
    Respir Med 105:533-40. 2011
    ..but the cut-points for changes in respiratory system conductance (Grs) and reactance (Xrs) that define a positive mannitol challenge are not known...
  56. ncbi Mannitol production from glycerol by resting cells of Candida magnoliae
    Asiya Khan
    Chemical Engineering and Process Development Division, National Chemical Laboratory, Dr Homi Bhabha Road, Pune, Maharashtra, India
    Bioresour Technol 100:4911-3. 2009
    Production of mannitol from glycerol by resting cells of Candida magnoliae under aerobic condition was investigated. The resting cells were suspended in aqueous solution of glycerol in Erlenmeyer flasks and incubated on rotary shaker...
  57. ncbi Injectable and macroporous calcium phosphate cement scaffold
    Hockin H K Xu
    Paffenbarger Research Center, 100 Bureau Drive, Stop 8546, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899 8546, USA
    Biomaterials 27:4279-87. 2006
    ..Water-soluble mannitol was used as porogen and mixed with CPC at mass fractions from 0% to 50%...
  58. pmc Reductions in workload and reporting time by use of methicillin-resistant Staphylococcus aureus screening with MRSASelect medium compared to mannitol-salt medium supplemented with oxacillin
    Philippe R S Lagacé-Wiens
    Clinical Microbiology, Saint Boniface General Hospital, Winnipeg, Manitoba R2H 2A6, Canada
    J Clin Microbiol 46:1174-7. 2008
    ..33 days for all MRSA screening specimens, 1.97 days for MRSA-positive specimens, and 1.3 days for MRSA-negative specimens compared to standard mannitol-salt agar supplemented with 6 mg of oxacillin/liter.
  59. ncbi Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase
    Jin Shuen Chen
    Graduate Institute of Medical Sciences, National Defense Medical Center, and Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 11:142-51. 2004
    Hyperglycemia and mannitol activate protein kinase C (PKC) and induce mesangial cell hypocontractility that subsequently may modulate renal function...
  60. pmc Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo
    Allan Jefferson Guimarães
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Cell Microbiol 12:740-53. 2010
    ..In this study, we determined the effects of mannitol and glucose on the capsule and exopolysaccharide production...
  61. pmc Identification of Staphylococcus aureus: DNase and Mannitol salt agar improve the efficiency of the tube coagulase test
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Upper Mulago hill road, Kampala, Uganda
    Ann Clin Microbiol Antimicrob 9:23. 2010
    ..aureus and is routinely done using either human or sheep plasma. This study evaluated Mannitol salt agar and the deoxyribonuclease (DNase) test for improving the efficiency of the tube coagulase test in ..
  62. ncbi Nuclear fusion leads to chromosome doubling during mannitol pretreatment of barley (Hordeum vulgare L.) microspores
    K J Kasha
    Department of Plant Agriculture, Biotechnology Division, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Bot 52:1227-38. 2001
    ..3 M mannitol pretreatment of anthers at 25 degrees C. However, during a 4 d pretreatment in 0...
  63. ncbi Overexpression of mtlD gene in transgenic Populus tomentosa improves salt tolerance through accumulation of mannitol
    Lei Hu
    The Tree and Ornamental Plant Breeding and Biotechnology Laboratory of State Forestry Administration, Beijing 100083, P R China
    Tree Physiol 25:1273-81. 2005
    The mtlD gene encoding mannitol-1-phosphate dehydrogenase, which catalyzes the biosynthesis of mannitol from fructose, was cloned from Escherichia coli and transferred to poplar (Populus tomentosa Carr...
  64. ncbi Metabolic engineering of Escherichia coli: construction of an efficient biocatalyst for D-mannitol formation in a whole-cell biotransformation
    B Kaup
    Institut für Biotechnologie 1, Forschungszentrum Julich GmbH, 52425 Julich, Germany
    Appl Microbiol Biotechnol 64:333-9. 2004
    A whole-cell biotransformation system for the conversion of d-fructose to d-mannitol was developed in Escherichia coli by constructing a recombinant oxidation/reduction cycle...
  65. ncbi Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial
    Joseph T Santoso
    University of Tennessee Cancer Institute, Memphis 38104, USA
    Cancer Chemother Pharmacol 52:13-8. 2003
    To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity.
  66. ncbi Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New Guinea
    B Genton
    Papua New Guinea Institute of Medical Research, Goroka and Maprik, Papua New Guinea
    Vaccine 18:2504-11. 2000
    ..The vaccine induced good cellular responses, especially for MSP1 and RESA. Boosting of humoral responses was weak, probably because of high baseline antibody levels...
  67. pmc Possible roles for mannitol and mannitol dehydrogenase in the biotrophic plant pathogen Uromyces fabae
    Ralf T Voegele
    Phytopathologie, Fachbereich Biologie, Universitat Konstanz, 78457 Konstanz, Germany
    Plant Physiol 137:190-8. 2005
    Levels of the C6-polyol mannitol were observed to rise dramatically in the biotrophic interaction of the rust fungus Uromyces fabae and its host plant Vicia faba...
  68. pmc Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming
    Danila Valmori
    Ludwig Institute Clinical Trial Center, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:8947-52. 2007
    ....
  69. pmc Mannitol as adjunct therapy for childhood cerebral malaria in Uganda: a randomized clinical trial
    Beatrice Namutangula
    Department of Paediatrics and Child Health, Makerere University Medical School, P O Box 7072 Kampala Uganda
    Malar J 6:138. 2007
    ..b>Mannitol, an osmotic diuretic, effectively lowers ICP and is used to treat post-traumatic raised ICP...
  70. ncbi Inhaled dry powder mannitol in cystic fibrosis: an efficacy and safety study
    D Bilton
    Royal Brompton Hospital, London, SW3 6NP, UK
    Eur Respir J 38:1071-80. 2011
    This international phase III study of inhaled dry powder mannitol was a randomised, double-blind, 26-week study, followed by a further 26-week, open-label (OL) extension...
  71. pmc Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51
    Socrates Herrera
    Instituto de Inmunologia, Facultad de Salud, Universidad del Valle, Cali, Colombia
    Am J Trop Med Hyg 84:12-20. 2011
    ..Vaccines in Montanide ISA 51 showed a higher sporozoite protein recognition and interferon production. Results encourage further testing of the vaccine protective efficacy...
  72. ncbi The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene
    M J Arias
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Sevilla, Spain
    J Drug Target 2:45-51. 1994
    ..This method involves preparation by the melting carrier method using D-mannitol as matrix. These systems were subjected to USP XXII dissolution rate determination...
  73. ncbi Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers
    William Glover
    Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    Int J Pharm 349:314-22. 2008
    ..We investigated the dose and distribution of radiolabelled powder aerosols of mannitol in the lungs using single photon emission tomography (SPECT)...
  74. ncbi Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin
    Joseph Cuschieri
    Department of Surgery, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Immunol 168:1389-96. 2002
    ..Selected cells were preconditioned with 40-100 mM of NaCl, mannitol, or urea for 4 h and returned to isotonic medium before LPS stimulation...
  75. ncbi Biotechnological production of mannitol and its applications
    Badal C Saha
    Bioenergy Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, Peoria, IL 61604, USA
    Appl Microbiol Biotechnol 89:879-91. 2011
    b>Mannitol, a naturally occurring polyol (sugar alcohol), is widely used in the food, pharmaceutical, medical, and chemical industries...
  76. ncbi Salicylic acid stimulates secretion of the normally symplastic enzyme mannitol dehydrogenase: a possible defense against mannitol-secreting fungal pathogens
    Fang yi Cheng
    Department of Horticultural Science, North Carolina State University, Raleigh, NC 27695 7609, USA
    Planta 230:1093-103. 2009
    The sugar alcohol mannitol is an important carbohydrate with well-documented roles in both metabolism and osmoprotection in many plants and fungi...
  77. ncbi Furosemide and mannitol suppression of epileptic activity in the human brain
    Michael M Haglund
    Department of Surgery Neurosurgery and Neurobiology, Durham, NC 27710, USA
    J Neurophysiol 94:907-18. 2005
    ..intravenous injection containing either 20 mg furosemide (a cation-chloride cotransporter antagonist) or 50 g mannitol (an osmolyte)...
  78. ncbi Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice
    E Mata
    Pharmacy and Pharmaceutical Technology Laboratory, Pharmacy Faculty, University of the Basque Country UPV EHU, Paseo de la Universidad 7, 01006 Vitoria Gasteiz, Spain
    Vaccine 25:877-85. 2007
    ..Our results demonstrate the ability of the polymer microparticles to overcome the lack of immunogenicity of FC27 MSP2 peptide in C57BL mice and their potential to induce desirable immune responses against malaria...
  79. ncbi Inhaled mannitol improves lung function in cystic fibrosis
    Anna Jaques
    Department of Clinical Research, Pharmaxis Ltd, Frenchs Forest, NSW, Australia
    Chest 133:1388-96. 2008
    ..The clearance of mucus is an integral component of daily therapy. Inhaled mannitol is an osmotic agent that increases the water content of the airway surface liquid, and improves the clearance of ..
  80. ncbi Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects
    John D Brannan
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Respirology 7:37-44. 2002
    The aim of the study was to investigate whether treatment using inhaled corticosteroids decreases airway responsiveness to inhaled mannitol in asthmatic subjects.
  81. ncbi Mannitol metabolism in the phytopathogenic fungus Alternaria alternata
    Heriberto Vélëz
    Department of Plant Pathology, NC State University, Raleigh, NC 27695, USA
    Fungal Genet Biol 44:258-68. 2007
    b>Mannitol metabolism in fungi is thought to occur through a mannitol cycle first described in 1978. In this cycle, mannitol 1-phosphate 5-dehydrogenase (EC 1.1.1...
  82. ncbi The use of 23.4% hypertonic saline for the management of elevated intracranial pressure in patients with severe traumatic brain injury: a pilot study
    Andrew J Kerwin
    Department of Surgery, University of Florida Health Science Center, Jacksonville, Florida 32209, USA
    J Trauma 67:277-82. 2009
    Oncotic agents are a therapeutic mainstay for the management of intracranial hypertension. Both mannitol and varied concentrations of hypertonic saline (HTS) have been shown to be effective at reducing elevated intracranial pressure (ICP)...
  83. ncbi Changes induced by hyperosmotic mannitol in cerebral endothelial cells: an atomic force microscopic study
    Zoltan Balint
    Institute of Biophysics, Biological Research Center of Hungarian Academy of Sciences, Temesvari krt 62, Szeged 6726, Hungary
    Eur Biophys J 36:113-20. 2007
    ..b>Mannitol, a cell-impermeable non-toxic alcohol, has been used successfully for reversible opening of the blood-brain ..
  84. ncbi Red blood cell aging markers during storage in citrate-phosphate-dextrose-saline-adenine-glucose-mannitol
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Transfusion 50:376-89. 2010
    ..It has been suggested that red blood cell (RBC) senescence is accelerated under blood bank conditions, although neither protein profile of RBC aging nor the impact of additive solutions on it have been studied in detail...
  85. ncbi Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol
    Anita S Galvez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago 6640750, Chile
    J Biol Chem 278:38484-94. 2003
    ..stress, elicited by exposure of cultured rat cardiac myocytes to the nonpermeant solutes sorbitol and mannitol, caused identical cell shrinkage and adaptive hexose uptake stimulation...
  86. ncbi Potassium sparing diuretics as adjunct to mannitol therapy in neurocritical care patients with cerebral edema: effects on potassium homeostasis and cardiac arrhythmias
    Federico Bilotta
    Department of Anesthesiology, Critical Care and Pain Medicine, Sapienza University Rome, Viale Acherusio 16, 00199 Rome, Italy
    Neurocrit Care 16:280-5. 2012
    b>Mannitol therapy to treat cerebral edema induces osmotic diuresis and electrolyte loss. In neurocritical care patients, potassium is the electrolyte that most often needs replacement...
  87. pmc A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)
    Ronit Shaltiel-Karyo
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 288:17579-88. 2013
    ..Here, we examined the ability of mannitol to interfere with the aggregation process of α-synuclein in vitro and in vivo in addition to its blood-brain ..
  88. ncbi Improvement of mannitol lysine crystal violet brilliant green agar for the selective isolation of H2S-positive Salmonella
    H Kodaka
    Research Department, Nissui Diagnostics, Yuki, Ibaraki, Japan
    J Food Prot 63:1643-7. 2000
    b>Mannitol lysine crystal violet brilliant green agar (MLCB) is widely used in Japan for Salmonella isolation because the medium has been commercially available...
  89. ncbi Improvement of pulmonary preservation with Celsior and Perfadex: impact of storage time on early post-ischemic lung function
    T Wittwer
    Department of Cardiothoracic and Vascular Surgery, Hannover Medical School, Germany
    J Heart Lung Transplant 18:1198-201. 1999
    ..Optimal preservation of post-ischemic organ function is a continuing challenge in clinical lung transplantation...
  90. ncbi A short period of mannitol stress but not LiCl stress led to global translational repression in plants
    Hideyuki Matsuura
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Biosci Biotechnol Biochem 74:2110-2. 2010
    ..In this study, we found that treatment with mannitol, but not lithium stress, led to rapid global translational repression, suggesting that a rapid response at the ..
  91. ncbi Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement on mechanical properties
    H H Xu
    Paffenbarger Research Center, American Dental Association Health Foundation, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8546, Gaithersburg, Maryland 20899, USA
    J Biomed Mater Res 57:457-66. 2001
    ..Water-soluble mannitol crystals were incorporated into CPC paste; the set CPC was then immersed in water to dissolve mannitol, producing ..
  92. ncbi Retrograde flush perfusion with low-potassium solutions for improvement of experimental pulmonary preservation
    T Wittwer
    Department of Cardiac Surgery, Thoracic and Vascular Surgery, Friedrich Schiller University, Jena, Germany
    J Heart Lung Transplant 19:976-83. 2000
    ..So far, we have seen no experimental studies that include stereologic analysis of intrapulmonary edema concerning the influence of retrograde preservation on post-ischemic lung function after preservation with Perfadex and Celsior...
  93. ncbi Fast-setting calcium phosphate scaffolds with tailored macropore formation rates for bone regeneration
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    J Biomed Mater Res A 68:725-34. 2004
    ..Absorbable fibers and mannitol porogen were incorporated into CPC for strength and macropores for bone ingrowth...
  94. pmc Mannitol-containing macroporous calcium phosphate cement encapsulating human umbilical cord stem cells
    Minghui Tang
    Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
    J Tissue Eng Regen Med 6:214-24. 2012
    ..The objective of this study was to develop a self-setting, mannitol-containing calcium phosphate cement (CPC) encapsulating human umbilical cord mesenchymal stem cells (hUCMSCs) for ..
  95. pmc From alcohol dehydrogenase to a "one-way" carbonyl reductase by active-site redesign: a mechanistic study of mannitol 2-dehydrogenase from pseudomonas fluorescens
    Mario Klimacek
    Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12 I, A 8010 Graz, Austria
    J Biol Chem 285:30644-53. 2010
    ..However, the mechanistic basis underpinning this discrimination is weak. In mannitol 2-dehydrogenase from Pseudomonas fluorescens, stabilization of (partial) negative charge on the substrate ..
  96. ncbi Therapeutic effects and mechanisms of action of mannitol during H2O2-induced oxidative stress in human retinal pigment epithelium cells
    Jorn Hon Liu
    Department of Ophthalmology, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
    J Ocul Pharmacol Ther 26:249-57. 2010
    ..Early prevention with antioxidants is mandatory. The aim of this study was to determine whether and how mannitol can act as an antioxidant.
  97. ncbi 2,5-Anhydro-D-mannitol increases hepatocyte sodium: transduction of a hepatic hunger stimulus?
    Mark I Friedman
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1642:53-8. 2003
    ..into a hepatic neuronal signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro-D-mannitol (2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using 23Na nuclear magnetic ..
  98. ncbi Relative effects of mannitol and hypertonic saline on calpain activity, apoptosis and polymorphonuclear infiltration in traumatic focal brain injury
    Jean F Soustiel
    Acute Brain Injury Research Laboratory and B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Brain Res 1101:136-44. 2006
    The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion...
  99. ncbi Influence of process variable and physicochemical properties on the granulation mechanism of mannitol in a fluid bed top spray granulator
    Jonathan Bouffard
    Department of Chemical Engineering, Ecole Polytechnique de Montreal, P O Box 6079 Stn Centreville, Quebec, Canada
    Drug Dev Ind Pharm 31:923-33. 2005
    ..the hydroxypropyl cellulose (HPC) binder solution atomization, on the fluidized bed top spray granulation of mannitol. Special attention was given to the relationship between wetting and the granule growth profile...
  100. ncbi The effect of cardioplegic solution-induced sodium concentration fluctuation on postoperative seizure in pediatric cardiac patients
    Jin Tae Kim
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Ann Thorac Surg 91:1943-8. 2011
    ..We evaluated the relationship between the cardioplegic solution, the fluctuation of sodium concentration, and the incidence of postoperative seizure in pediatric cardiac patients...
  101. ncbi Purification and characterization of mannitol dehydrogenase and identification of the corresponding cDNA from the head blight fungus, Gibberella zeae (Fusarium graminearum)
    Frances Trail
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824 1312, USA
    Phytochemistry 61:791-6. 2002
    The mannitol-2-dehydrogenase (MtDH) from Gibberella zeae was purified and the corresponding cDNA identified...

Research Grants62

  1. New insights in mechanisms of renal injury
    Balakuntalam S Kasinath; Fiscal Year: 2013
    ..MCT), glomerular epithelial and mesangial cells (GEC) will be incubated with high glucose, or , equimolar mannitol, or, 5 mM glucose for up to 48 hrs. Under these conditions the following studies will be done. A...
  2. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..aims will address the central hypotheses that 1) increased levels of biomarkers (serum zonulin, Lactulose/Mannitol urine ratio, and/or fecal a-1 anti-trypsin) will identify infants with increased intestinal permeability;and 2) ..
  3. The human gut microbiome, malnutrition and vaccine responses
    ANDREW LEON KAU; Fiscal Year: 2013
    ..I will define their gut mucosal barrier function by serum LPS assays, lactulose/mannitol absorption assays, histo- and immunohistochemical assays of gut morphology and immune cell populations (exploring ..
  4. HIV, ART and the Intestinal Microbiota
    Honorine D Ward; Fiscal Year: 2012
    ..Our group is conducting a study of intestinal mucosal integrity (determined by lactulose:mannitol permeability) in HIV-infected individuals before and after they initiate ART, in rural Tamil Nadu, where rates of ..
  5. Early Dietary Intervention and Later Signs of Beta-Cell Autoimmunity: Potential M
    Mikael Knip; Fiscal Year: 2012
    ..Intestinal permeability will be assessed with the lactulose/mannitol test at the age of 3, 6, 9, and 12 months...
  6. Small RNAs and Vibrio cholerae adaptation to different carbon sources
    JANE MAY LIU; Fiscal Year: 2010
    ..data suggests that an sRNA, MtlS, is expressed in a regulated manner and inhibits the expression of mtlA, the mannitol- specific transporter of V. cholerae. The central hypothesis is that V...
  7. IMPACT OF INTESTINAL DYSFUNCTION ON ANTIRETROVIRAL THERAPY IN INDIA
    RITA CAROLINE ISAAC; Fiscal Year: 2012
    ..in a cohort of HIV infected individuals in India, at the time of initiation of HAART using the tests d-xylose and mannitol:lactulose excretion in the urine following oral administration of these sugars...
  8. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    MICHAEL BENNISH; Fiscal Year: 2002
    ..4) To determine if micronutrient supplementation improves gut integrity as measured by the mannitol-lactulose permeability test...
  9. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    Sherwood Gorbach; Fiscal Year: 2005
    ..4) To determine if micronutrient supplementation improves gut integrity as measured by the mannitol-lactulose permeability test...
  10. EFFECTS OF ADRIAMYCIN AND BCNU ON GLUTATHIONE
    Henry Kaplan; Fiscal Year: 1980
    ..In addition, quenchers of free radicals and singlet oxygen, such as tocopherol, mannitol and carotene will be evaluated, as will superoxide dismutase, N-acetyl cystein and drugs which have been reported ..
  11. Modulating the BBB to Improve Drug Delivery to the Brain
    Teruna J Siahaan; Fiscal Year: 2013
    ..We found that an HAV peptide can improve the permeation of mannitol and an anticancer agent (daunomycin) into the brain using the in-situ brain perfusion rat model...
  12. HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERY
    Michael Todd; Fiscal Year: 2003
    ..teams utilize some method to protect patients during surgery, including barbiturates, etomidate, steroids, mannitol or varying degrees of hypothermia...
  13. EXOCYTIC INSERTION OF POTASSIUM CHANNELS IN MEMBRANES
    William Moran; Fiscal Year: 2001
    ..G proteins, 3) determine the effect of alanine on enterocyte volume; and 4) assess the effect of 10 nM mannitol (control) and 10 mM alanine (treatment) on number of K channels in the apical membrane...
  14. CONTROL OF CEREBRAL REPERFUSION AFTER CARDIAC ARREST
    Peter Safar; Fiscal Year: 1990
    ..In years 3 and 4 we propose to test a cerebral edema reducing therapy (e.g., mannitol i.v.) designed according to the results of years 1 and 2...
  15. FRUCTOFURANOSE MODULATORS--STRUCTURAL/ENZYMATIC STUDIES
    EZZAT YOUNATHAN; Fiscal Year: 1992
    ..Interest in this group of compounds was kindled by our discovery of the hypoglycemic effect of 2,5-anhydro-D-mannitol (2,5-AM) in normal and diabetic animals...
  16. ELECTRON TRANSPORT VARIANTS IN STAPHYLOCOCCAL DISEASE
    Richard Proctor; Fiscal Year: 2001
    ..in liquid medium) and misidentify ETVs because they are atypical (slowly coagulase positive, non-hemolytic, mannitol negative, non-pigmented)...
  17. Improved Suicide Gene Therapy for Hepatic Cancers
    William Ensminger; Fiscal Year: 2005
    ..In addition, we will enhance regional delivery of virus using vascular manipulations (Aim 3), including osmotic (mannitol), mechanical (microspheres) and hormonal (epinephrine) methods, and pretreatment with focal ionizing radiation...
  18. IONIC BASIS OF ISCHEMIC CEREBRAL EDEMA
    Wise Young; Fiscal Year: 1992
    ..The effects of systemic furosemide, mannitol, and/or methylprednisolone on extracellular and tissue ionic shifts will be studied in the rat MCAo and cortical ..
  19. MECHANISMS OF BRAIN DEHYDRATION WITH OSMOTIC DIURETICS
    Stanley Nelson; Fiscal Year: 1980
    ..The effectiveness of glycerol, urea and mannitol will be compared...
  20. Retinal blood barrier permeability using optical tracers
    FREDERICK HASELTON; Fiscal Year: 2004
    ..We have obtained preliminary induced by 5 minutes of mannitol infusion. Three aims for further studies are proposed...
  21. ENZYME &GENE REPLACEMENT IN GM2 GANGLIOSIDOSIS
    MARIO RATTAZZI; Fiscal Year: 1990
    ..Reversible blood-brain barrier permeability will be obtained by hyperosmotic mannitol infusion; the efficiency of enzyme delivery and physiopathologic consequences will be assessed; retrograde axonal ..
  22. CRYPTOCOCCUS NEOFORMANS--OXIDATIVE KILLING MECHANISMS
    Vishnu Chaturvedi; Fiscal Year: 2001
    ..Also, preliminary observations suggest that a distal neutrophil oxidant is fungicidal and that fungal mannitol may protect from oxidative killing...
  23. BLOOD PRESSURE AND PROXIMAL TUBULE TRANSPORT
    FRANKLYN KNOX; Fiscal Year: 2000
    ..lanthranum on Jv, net fluid reabsorption by the proximal tubule will be inhibited by adding an impermeant solute, mannitol, to the luminal fluid...
  24. MODULATION OF LUNG ENDOTHELIAL PERMEABILITY BY AUTACOIDS
    FREDERICK HASELTON; Fiscal Year: 1992
    ..three main aims: 1) to measure the in vitro intercellular permeability of the pulmonary endothelial cell layer to mannitol and polyethylene glycol; 2) to characterize the permeability of the pulmonary endothelial cell layer with respect ..
  25. Estimating Intracellular Lithium in Brain in vivo by 7Li MRS
    Richard A Komoroski; Fiscal Year: 2010
    ..and extracellular signals by measuring the separate intra- and extracellular 7Li signals after infusion of mannitol to disrupt the blood-brain barrier and a thulium-based compound to separate the two signals...
  26. Delivery of Agents by Modulating Junctions with Zot
    Natalie Eddington; Fiscal Year: 2006
    ..SA3. To examine the ability of Zot to enhance the oral bioavailability of the hydrophilic agents (mannitol, inulin) and therapeutic macromolecules (insulin, cyclosporin A, paclitaxel)...
  27. Production of L-Ribose and Rare Sugars
    Ryan Woodyer; Fiscal Year: 2007
    ..We propose a fermentative route to the production of L-ribose and other rare sugars using a mannitol-1- dehydrogenase (MDH)...
  28. Vaccine and Magnetic Resonance Imaging Approaches for AD
    Martin Sadowski; Fiscal Year: 2003
    ..Results of our preliminary studies indicates that native A-beta bound to gadolinium co-injected with mannitol or putrescine modified A-beta bound to gadolinium can cross the BBB and act as a contrast agent for amyloid ..
  29. MOLECULAR MECHANISMS OF BLOOD-BRAIN BARRIER DYSFUNCTION
    Harold Koenig; Fiscal Year: 1991
    ..1.6 M mannitol is infused into the right carotid artery of rats to induce reversible BBB opening...
  30. HORMONAL REGULATION OF BRAIN MATURATION
    BARBARA STONESTREET; Fiscal Year: 2000
    ..Brain volume, water and electrolytes, are measured by standard methods and graded osmotic stress achieved with mannitol. The hypothesis to be tested is that steroid preteatment improves brain volume regulation in fetuses and newborns...
  31. MANNITOL AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANS
    Brian Wong; Fiscal Year: 2002
    DESCRIPTION. (Adapted from Applicant's Abstract) Cryptococcus neoformans produces large amounts of mannitol in culture and in infected animals, and a mannitol-underproducing C. neoformans mutant is stress-intolerant and hypovirulent...
  32. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..aim to determine whether two interventions, bumetanide (a specific inhibitor of NaCl transport by the BBB), and mannitol (an osmotic agent which enhances cerebral perfusion) prevent or ameliorate CE in DKA and whether these agents ..
  33. CLINIC PATHOPHYSIOLOGY OF ACUTE BRAIN INJURY
    Michael Diringer; Fiscal Year: 2007
    ..In Project 3, Drs. Michael Diringer and Robert Grubb will investigate the pathophysiological effects of mannitol and hypertonic saline on brain edema due to ischemic stroke and head trauma...
  34. CLINIC PATHOPHYSIOLOGY OF ACUTE BRAIN INJURY
    Michael Diringer; Fiscal Year: 2006
    ..In Project 3, Drs. Michael Diringer and Robert Grubb will investigate the pathophysiological effects of mannitol and hypertonic saline on brain edema due to ischemic stroke and head trauma...
  35. REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION
    JEFF SANDS; Fiscal Year: 1993
    ..Specific Aim 1 will test the effect of increasing perfusate and bath osmolality by adding either NaCl or mannitol on IMCD urea permeability...
  36. ISCHEMIA AND CEREBRAL BLOOD VOLUME IN HUMAN HEAD INJURY
    J Muizelaar; Fiscal Year: 1993
    ..g. by induced hypertension, or mannitol therapy), while understanding of the pathophysiology of increased ICP and brain stiffness will lead to more ..
  37. ETHANOL & FAT INDUCED INSULIN RESISTANCE IN THE ELDERLY
    Guenther Boden; Fiscal Year: 1999
    ..acids on glucose transport will be examined in vivo using a dual tracer technique (3-0-methyl-D-glucose and D-mannitol) in combination with the forearm balance method and euglycemic-hyperinsulinemic clamping and in vitro in rat ..
  38. F UPTAKE AND BINDING BY EARLY ENAMEL MATRIX
    JAMES BAWDEN; Fiscal Year: 1990
    ..of enamel and its relative capacity for fluoride uptake during its various stages of development by using 3H-mannitol to correct for water loss that occurs during enamel collection and the assay procedure; (2) to determine by ..
  39. HETEROGENEITY CELL CALCIUM DISTRIBUTION RENAL HYPOXIA
    EDORIS LE FURGEY; Fiscal Year: 1990
    ..will also be examined that preserve renal function during anoxia, such as the presence of adenine nucleotides, mannitol, and low pH in the bathing medium...
  40. GF REGULATION/GASTRIC MUCOSAL PARACELLULAR PERMEABILITY
    ANDREW SOLL; Fiscal Year: 2003
    ..effects on paracellular permeability and barrier function, as measured by transepithelial resistance and by mannitol and inulin flux, will be compared...
  41. METABOLIC STUDIES OF OPPORTUNISTIC FUNGI AND PROTOZOA
    Peter Walzer; Fiscal Year: 1993
    ..carinii. Project 4 is concerned with D-mannitol metabolism in Cryptococcus neoformans...
  42. In Vitro Method for Gut Absorption and Cytotoxicity
    FRANK BARILE; Fiscal Year: 2003
    ..in vitro is determined using markers for paracellular permeability, including Lucifer yellow, FITC-dextran, [3H]-mannitol permeability, and transepithelial electrical resistance (TEER) measurements...
  43. POLY ADP RIBOSYLTRANSFERASE IN HEMORRHAGIC SHOCK
    Csaba Szabo; Fiscal Year: 2001
    ..The relative contribution of hydroxyl radical will be investigated using mannitol. Third, the role of PARS in regulating iNOS expression will be investigated...
  44. PHASE VARIATION IN SACCHAROMYCES CEREVISIAE
    JOHN MCCUSKER; Fiscal Year: 2003
    ..The second form of phase variation described by the investigator is switching between mannitol utilization states...
  45. ACUTE RENAL FAILURE FOLLOWING CARDIAC SURGERY
    Mark Hilberman; Fiscal Year: 1980
    ..A comparison of the renal functional effects of routine mannitol adminstration, manitol adminstration prior to CPB, and high dose mannitol administration will be performed. 4...
  46. GI BARRIER HEAT INJURY--SYSTEMIC & MOLECULAR MECHANISMS
    Larry Oberley; Fiscal Year: 2002
    ..in vivo (51Cr-EDTA clearance, portal vein LPS levels, TNF, and HSP and inducible nitric oxide synthase levels, mannitol permeability) whether membrane function is altered by the elevations in ROS induced by heating, by dietary means ..
  47. Effects of Hyaluronan on Interstitial Convection
    MICHAEL FLESSNER; Fiscal Year: 2007
    ..The results of this research project will provide a basis for future work designed to preserve or enhance the transport characteristics of peritoneal tissue during chronic dialysis. ..
  48. PERITONEAL DELIVERY OF ANTINEOPLASTIC MACROMOLECULES
    MICHAEL FLESSNER; Fiscal Year: 2004
    ....
  49. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  50. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
  51. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  52. Activated Sugars for Drug Discovery
    Ryan Woodyer; Fiscal Year: 2006
    ..These sugars can be used to make derivatives of natural products with new therapeutic properties, for example, antibiotics that are effective against antibiotic-resistant bacteria. [unreadable] [unreadable] [unreadable]..
  53. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..abstract_text> ..
  54. METABOLIC CONTROL OF FEEDING BEHAVIOR
    Mark Friedman; Fiscal Year: 2005
    ..2) Determine whether overeating in obesity prone rats is due to a slow restoration of liver energy status. (3) Determine whether calcium signaling during metabolic stimulus transduction differs in hepatocytes from lean and obese rats. ..
  55. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..2,5-anhydro-D-mannitol (2,5-AM) and mercaptoacetate (MA), are two metabolic inhibitors with different actions that stimulate feeding ..
  56. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  57. HEPATIC MECHANISM FOR CONTROL OF FOOD INTAKE
    Mark Friedman; Fiscal Year: 2003
    ..To address this, an experiment will be performed to determine whether a metabolic hunger signal originates from hepatocytes. ..
  58. B7-DC Cross-linking antibody immunotherapy
    Svetomir Markovic; Fiscal Year: 2008
    ..If successful, this "proof-of-principle" clinical trial will justify further development of B7-DC XAb as a cancer therapeutic with potential universal application for all malignant disorders. [unreadable] [unreadable] [unreadable]..