lipase

Summary

Summary: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.

Top Publications

  1. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
  2. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
  3. pmc ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Nat Med 17:1076-85. 2011
  4. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
  5. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
  6. ncbi Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
  7. pmc The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects
    Marta Yanina Pepino
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:561-6. 2012
  8. pmc Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California Berkeley, CA 94720, USA
    Cell Metab 13:739-48. 2011
  9. ncbi Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
  10. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010

Detail Information

Publications388 found, 100 shown here

  1. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..We showed that genetic inactivation of adipose triglyceride lipase (ATGL) in mice increases adipose mass and leads to triacylglycerol deposition in multiple tissues...
  2. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
    ..Thus, variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD...
  3. pmc ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Nat Med 17:1076-85. 2011
    ..Here we show that lipolysis of cellular triglycerides by adipose triglyceride lipase (patatin-like phospholipase domain containing protein 2, encoded by Pnpla2; hereafter referred to as Atgl) ..
  4. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
    ....
  5. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
    ..times of energy deficit, perilipin is phosphorylated by PKA and facilitates maximal lipolysis by hormone-sensitive lipase and adipose triglyceride lipase...
  6. ncbi Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
    ..45 ± 1.04; P < 0.02). The rs738409 GG genotype versus the CC genotype was associated with a 28% increase in serum alanine aminotransferase levels...
  7. pmc The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects
    Marta Yanina Pepino
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:561-6. 2012
    ..nucleotide polymorphism (rs1761667) in the CD36 gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate ..
  8. pmc Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California Berkeley, CA 94720, USA
    Cell Metab 13:739-48. 2011
    ..Overall, desnutrin is phosphorylated/activated by AMPK to increase lipolysis and brings FA oxidation and UCP-1 induction for thermogenesis...
  9. ncbi Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
    ..We show that the inhibition of lipolysis through genetic ablation of adipose triglyceride lipase (Atgl) or hormone-sensitive lipase (Hsl) ameliorates certain features of cancer-associated cachexia (CAC)...
  10. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258)...
  11. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in vitro assays ..
  12. ncbi Bacterial lipases: an overview of production, purification and biochemical properties
    R Gupta
    Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, 110 021 New Delhi, India
    Appl Microbiol Biotechnol 64:763-81. 2004
    ..Some important lipase-producing bacterial genera include Bacillus, Pseudomonas and Burkholderia...
  13. ncbi Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation
    Andrew J Hoy
    Monash University, Department of Physiology, Wellington Road, Clayton Victoria, 3800, Australia
    Endocrinology 152:48-58. 2011
    Adipose triglyceride lipase (ATGL) null (-/-) mice store vast amounts of triacylglycerol in key glucoregulatory tissues yet exhibit enhanced insulin sensitivity and glucose tolerance...
  14. pmc Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-α (TNF-α)-induced lipolysis in adipocytes
    Xingyuan Yang
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Biol Chem 286:40477-85. 2011
    ..Recent studies show that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) act sequentially in catalyzing the first two steps of adipose lipolysis ..
  15. pmc Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1
    Karin Heurlier
    Institut de Microbiologie Fondamentale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Bacteriol 186:2936-45. 2004
    ..RsmA was found to control positively the ability to swarm and to produce extracellular rhamnolipids and lipase, i.e., functions contributing to niche colonization by P. aeruginosa...
  16. ncbi Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
    Sebastian Gronke
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, 37077 Gottingen, Germany
    Cell Metab 1:323-30. 2005
    ..The brummer (bmm) gene encodes the lipid storage droplet-associated TAG lipase Brummer, a homolog of human adipocyte triglyceride lipase (ATGL)...
  17. pmc Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
    Pierre Marie Badin
    INSERM, U1048, Obesity Research Laboratory, Institute of Metabolicand Cardiovascular Diseases I2MC, Toulouse, France
    Diabetes 60:1734-42. 2011
    ..DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL)...
  18. pmc Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
    Kuok Teong Ong
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108 1038, USA
    Hepatology 53:116-26. 2011
    ..Recent studies have identified adipose triglyceride lipase (ATGL) as a major lipase in adipose tissue, although its role in the liver is largely unknown...
  19. ncbi Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
    ..Currently, three enzymes are known to hydrolyze TG, the well-studied hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL), discovered more than 40 years ago, as well as the relatively recently ..
  20. pmc G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase
    Martina Schweiger
    Institute of Molecular Biosciences University of Graz, 8010 Graz, Austria
    J Lipid Res 53:2307-17. 2012
    ..Murine lipolysis largely depends on the activity of adipose triglyceride lipase (ATGL), which is regulated by two proteins annotated as comparative gene identification-58 (CGI-58) and G0/G1 ..
  21. ncbi pH-Induced molten globule state of Rhizopus niveus lipase is more resistant against thermal and chemical denaturation than its native state
    Gulam Rabbani
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    Cell Biochem Biophys 62:487-99. 2012
    ..4), acid-induced state, "A" (pH 2.2) and molten globule state, "MG" (pH 1.8) of Rhizopus niveus lipase (RNL) by CD, tryptophanyl fluorescence, ANS binding, DLS, and enzyme activity assay...
  22. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
    Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis in adipocytes...
  23. pmc Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport
    Wijtske Annema
    Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Curr Atheroscler Rep 13:257-65. 2011
    ..Hepatic lipase (HL) and endothelial lipase (EL) are negative regulators of plasma HDL cholesterol levels...
  24. pmc A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    Shaoqing He
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6706-15. 2010
    ..These data are consistent with PNPLA3-I148M promoting triglyceride accumulation by limiting triglyceride hydrolysis...
  25. pmc The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    Xingyuan Yang
    Department of Pediatrics, University of Kentucky, Lexington, USA
    Cell Metab 11:194-205. 2010
    Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG) hydrolysis in adipocytes. The precise mechanisms whereby ATGL is regulated remain uncertain...
  26. ncbi Adipocyte lipases and defect of lipolysis in human obesity
    Dominique Langin
    Obesity Research Unit, Institut National de la Sante et de la Recherche Medicale, Université Paul Sabatier UPS U586, Louis Bugnard Institute, Toulouse University Hospitals, Toulouse, France
    Diabetes 54:3190-7. 2005
    The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative importance in lipolysis is unknown...
  27. ncbi Two pathways for lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3, Aobayama, Aoba ku, Sendai, 980 8578, Japan
    Biochim Biophys Acta 1781:513-8. 2008
    ..One PA-selective PLA1 called mPA-PLA1alpha/LIPH is specifically expressed in hair follicles, where it has a critical role in hair growth by producing LPA through a novel LPA receptor called P2Y5...
  28. ncbi Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas
    J S Nachnani
    Division of Gastroenterology and Hepatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Diabetologia 53:153-9. 2010
    ..Previous studies have evaluated the effect of exendin-4 on beta cells and beta cell function. We evaluated the histological and biochemical effects of exendin-4 on the pancreas in rats...
  29. ncbi Lipases for biotechnology
    Karl Erich Jaeger
    Institute for Molecular Enzyme Technology, Heinrich Heine Universitat Dusseldorf, Forschungszentrum Julich, D 52425, Julich, Germany
    Curr Opin Biotechnol 13:390-7. 2002
    ..The optimisation of industrially relevant lipase properties can be achieved by directed evolution...
  30. ncbi Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidyl-peptidase-4 inhibitors in the outpatient setting
    Howard M Lando
    Department of Medicine, George Washington University, Washington, District of Columbia, USA
    Endocr Pract 18:472-7. 2012
    To investigate the effects of glucagonlike peptidase-1 (GLP-1) receptor agonists and dipeptidyl-peptidase-4 (DPP-4) inhibitors on serum amylase and serum lipase levels in patients with type 2 diabetes.
  31. ncbi Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles
    Karin Athenstaedt
    Institut fur Biochemie, Technische Universitat Graz, Austria
    J Biol Chem 280:37301-9. 2005
    ..Recently, Tgl3p was identified as a major TAG lipase of the yeast Saccharomyces cerevisiae (Athenstaedt, K., and Daum, G. (2003) J. Biol. Chem. 278, 23317-23323)...
  32. ncbi Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 51:1209-17. 2010
    ..12-2.04), and fibrosis stage >1 (OR = 1.5, 95% CI = 1.09-2.12), independent of age, body mass index, and diabetes. Adiponutrin genotype demonstrated a dose effect with heterozygote risk intermediate between CC and GG homozygotes...
  33. ncbi A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    A Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetologia 52:1056-60. 2009
    ....
  34. pmc Dysregulation of placental endothelial lipase in obese women with gestational diabetes mellitus
    Martin Gauster
    Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria
    Diabetes 60:2457-64. 2011
    This study addressed the hypothesis that placental endothelial lipase (EL) expression is affected by pregnancies complicated by obesity and gestational diabetes mellitus (GDM).
  35. pmc Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases
    Thomas O Eichmann
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 287:41446-57. 2012
    Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids. DAG exists in three stereochemical isoforms...
  36. pmc The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat
    Emanuele Miraglia del Giudice
    Department of Pediatrics, Seconda Universita degli Studi di Napoli, Napoli, Italy
    PLoS ONE 6:e27933. 2011
    ....
  37. ncbi A thermoalkaliphilic lipase of Geobacillus sp. T1
    Thean Chor Leow
    Enzyme and Microbial Technology Research Group, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia
    Extremophiles 11:527-35. 2007
    A thermoalkaliphilic T1 lipase gene of Geobacillus sp. strain T1 was overexpressed in pGEX vector in the prokaryotic system...
  38. ncbi Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Brussels, Belgium
    Hepatology 54:60-9. 2011
    ..64, 95% CI 1.22-5.67, P = 0.013). Conversely, rs738409 was not independently associated with treatment failure (OR 1.07, 95% CI 0.46-2.49, P = 0.875) and did not influence clinical or biological variables...
  39. pmc A feed-forward loop amplifies nutritional regulation of PNPLA3
    Yongcheng Huang
    Departments of Molecular Genetics and Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7892-7. 2010
    ....
  40. pmc Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:2616-23. 2009
    ..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance...
  41. ncbi Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro
    Masaaki Nakai
    Institute for Health Care Science and Suntory Institute for Bioorganic Research, Suntory, Ltd, 1 1 1 Wakayamadai, Osaka 618 8503, Japan
    J Agric Food Chem 53:4593-8. 2005
    Fifty-four polyphenols isolated from tea leaves were evaluated for their inhibitory activities against pancreatic lipase, the key enzyme of lipid absorption in the gut...
  42. ncbi Molecular dynamics studies on T1 lipase: insight into a double-flap mechanism
    Ying Wang
    College of Life Science and Biotechnology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China
    J Chem Inf Model 50:875-8. 2010
    T1 lipase is isolated from the palm Geobacillus zalihae strain T1 in Malaysia, functioning as a secreted protein responsible for the catalyzing hydrolysis of long-chain triglycerides into fatty acids and glycerol at high temperatures...
  43. pmc Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue
    Kathy Jaworski
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1-4. 2007
    ..Until recently, hormone-sensitive lipase was considered to be the key rate-limiting enzyme responsible for regulating TAG mobilization...
  44. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Animal models indicate that decreased expression of endothelial lipase (LIPG) is inversely associated with HDL-C levels, and genome-wide association studies have identified LIPG ..
  45. pmc Coatomer-dependent protein delivery to lipid droplets
    Krishnakant G Soni
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 122:1834-41. 2009
    ..have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to ..
  46. ncbi I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 52:1274-80. 2010
    ..Individuals carrying two minor G alleles almost always had severe steatosis and NASH, heterozygotes were at intermediate risk, and patients negative for G alleles had milder and often uncomplicated steatosis...
  47. ncbi YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae
    Karin Athenstaedt
    Institut fur Biochemie, Technische Universitat Graz, Petersgasse 12 2, A 8010 Graz, Austria
    J Biol Chem 278:23317-23. 2003
    ..These observations suggested that TGL3 may encode a TAG lipase of Saccharomyces cerevisiae...
  48. ncbi Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C
    Luca Valenti
    Department of Internal Medicine, Universita degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico Ca Granda IRCCS, Milan, Italy
    Hepatology 53:791-9. 2011
    ..47, 95% CI 1.2-1.9; P = 0.002), treatment response (n = 470; OR 0.63, 95% CI 0.4-0.8; P = 0.006), and HCC occurrence (n = 325; OR 2.16, 95% CI 1.3-3.6; P = 0.002), independently of confounders...
  49. ncbi Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    Felix Stickel
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
    Hepatology 53:86-95. 2011
    ..03). The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%...
  50. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
    ..our data suggest that the newly identified desnutrin gene codes for an adipocyte protein that may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other ..
  51. ncbi Characterization of the lipolytic activity of endothelial lipase
    Mary G McCoy
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 43:921-9. 2002
    Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity...
  52. ncbi Enhancing thermostability of a Rhizomucor miehei lipase by engineering a disulfide bond and displaying on the yeast cell surface
    Zhen lin Han
    Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, People s Republic of China
    Appl Microbiol Biotechnol 85:117-26. 2009
    To increase the thermostability of Rhizomucor miehei lipase, the software Disulfide by Design was used to engineer a novel disulfide bond between residues 96 and 106, and the corresponding double cysteine mutants were constructed. The R...
  53. pmc Display of bacterial lipase on the Escherichia coli cell surface by using FadL as an anchoring motif and use of the enzyme in enantioselective biocatalysis
    Seung Hwan Lee
    Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Appl Environ Microbiol 70:5074-80. 2004
    ..A thermostable Bacillus sp. strain TG43 lipase (44.5 kDa) could be successfully displayed on the cell surface of E...
  54. ncbi High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle
    Pierre Marie Badin
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse Cedex 4, France
    Endocrinology 154:1444-53. 2013
    Elevated expression/activity of adipose triglyceride lipase (ATGL) and/or reduced activity of hormone-sensitive lipase (HSL) in skeletal muscle are causally linked to insulin resistance in vitro...
  55. ncbi Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Am J Physiol Endocrinol Metab 297:E289-96. 2009
    ..Recently, two genes, adipose triglyceride lipase (ATGL/PNPLA2) and comparative gene identification-58 (CGI-58/ABHD5), have been shown to cause NLSD...
  56. pmc SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds
    Peter J Eastmond
    Department of Biology, Centre for Novel Agricultural Products, University of York, York YO10 5YW, United Kingdom
    Plant Cell 18:665-75. 2006
    ..Triacylglycerol hydrolase assays showed that sdp1, sdp2, and sdp3 seedlings are deficient specifically in the lipase activity that is associated with purified oil bodies...
  57. ncbi Variant in PNPLA3 is associated with alcoholic liver disease
    Chao Tian
    Perlegen Sciences, Mountain View, California, USA
    Nat Genet 42:21-3. 2010
    ..We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5))...
  58. ncbi Resveratrol regulates lipolysis via adipose triglyceride lipase
    Arrate Lasa
    Department of Nutrition and Food Science, University of Pais Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain
    J Nutr Biochem 23:379-84. 2012
    ..The specific purpose was to assess the involvement of the two main lipases: adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), in the activation of lipolysis induced by this molecule...
  59. pmc Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 55:781-9. 2012
    ..There was a joint effect between the PNPLA3 and GCKR SNPs, explaining 32% of HFF% variance in Caucasians (P = 0.00161), 39.0% in African Americans (P = 0.00000496), and 15% in Hispanics (P = 0.00342)...
  60. ncbi A novel endothelial-derived lipase that modulates HDL metabolism
    M Jaye
    Cardiovascular Biology Department, Rhone Poulenc Rorer Research and Development, Collegeville, Pennsylvania 19426 0107, USA
    Nat Genet 21:424-8. 1999
    ..Lipoprotein lipase (LPL) and hepatic lipase (HL), two members of the triacylglyerol (TG) lipase family, both influence HDL metabolism ..
  61. pmc The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 6:e27087. 2011
    ..I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC)...
  62. pmc Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
    Melissa L Borg
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Diabetes 60:1458-66. 2011
    ..have identified PEDF as a regulator of triacylglycerol metabolism in the liver that may act through adipose triglyceride lipase (ATGL). We used ATGL(-/-) mice to determine the role of PEDF in regulating lipid and glucose metabolism.
  63. ncbi Overview of fungal lipase: a review
    Abhishek Kumar Singh
    Department of Chemical Engineering, Sardar Vallabhbhai National Institute of Technology, Surat 395007 Gujarat, India
    Appl Biochem Biotechnol 166:486-520. 2012
    ..In this review paper, an overview regarding the fungal lipase production, purification, and application is discussed...
  64. ncbi Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers
    Karoline Etschmaier
    Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria
    J Neurochem 119:1016-28. 2011
    ..Adipose triglyceride lipase (ATGL) is encoded by the PNPLA2 gene and catalyzes the rate-limiting step of lipolysis...
  65. ncbi (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
    Kimberly A Grove
    Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania, USA
    Obesity (Silver Spring) 20:2311-3. 2012
    ..syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0...
  66. ncbi Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin
    Partha Chakrabarti
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Diabetes Rev 7:270-7. 2011
    ..suppresses lipolysis by down-regulating the expression of the rate-limiting lipolytic enzyme, adipose triglyceride lipase or ATGL...
  67. pmc Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Biol 32:740-50. 2012
    ..Myocardial triacylglycerol catabolism is mediated by adipose triglyceride lipase (ATGL), which is rate limiting for triacylglycerol hydrolysis...
  68. pmc The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    Yaron Rotman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
    Hepatology 52:894-903. 2010
    ..010). In children, no SNP was associated with histological severity. However, the rs738409 G allele was associated with younger age at the time of biopsy in multivariate analysis (P = 0.045)...
  69. ncbi Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes
    H Merzouk
    Laboratoire de Physiologie Animale, université de Tlemcen, Algerie
    Clin Sci (Lond) 98:21-30. 2000
    ..hyperphagic; however, they had higher food efficiency and fat storage capacity with higher adipocyte lipoprotein lipase activity, which contributed to persisting obesity...
  70. ncbi PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dig Liver Dis 44:1037-41. 2012
    ..In the present study we examined the association between the PNPLA3 I148M genetic variant and hepatocellular carcinoma in obese individuals from the Swedish Obese Subjects cohort (n = 4047)...
  71. pmc Multifunctionality and diversity of GDSL esterase/lipase gene family in rice (Oryza sativa L. japonica) genome: new insights from bioinformatics analysis
    Hanna Chepyshko
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan 402, ROC
    BMC Genomics 13:309. 2012
    ..Only two genes from a large rice GDSL esterase/lipase gene family were previously characterised, and the majority of the members remain unknown...
  72. pmc Involvement of a quorum-sensing-regulated lipase secreted by a clinical isolate of Burkholderia glumae in severe disease symptoms in rice
    Giulia Devescovi
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    Appl Environ Microbiol 73:4950-8. 2007
    ..We report that AHL quorum sensing in B. glumae AU6208 regulates secreted LipA lipase and toxoflavin, the phytotoxin produced by B. glumae. B...
  73. ncbi Natural inhibitors of pancreatic lipase as new players in obesity treatment
    Ana Laura de la Garza
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Planta Med 77:773-85. 2011
    ..This compound inhibits the activity of pancreatic lipase, which is one of the enzymes involved in fat digestion...
  74. ncbi Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    Jiang Wei Wu
    Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, China
    Hepatology 54:122-32. 2011
    ..are not well known in hepatocytes, but evidence suggests an important role in lipolysis for adipose triglyceride lipase (ATGL). We created mice with liver-specific inactivation of Pnpla2, the ATGL gene...
  75. ncbi Novel cation-pi interaction revealed by crystal structure of thermoalkalophilic lipase
    Hiroyoshi Matsumura
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2 1, Yamadaoka, Suita, Osaka 565 0871, Japan
    Proteins 70:592-8. 2008
  76. ncbi Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine
    M Gauster
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 III, Graz A 8010, Austria
    J Lipid Res 46:1517-25. 2005
    We assessed the ability of endothelial lipase (EL) to hydrolyze the sn-1 and sn-2 fatty acids (FAs) from HDL phosphatidylcholine...
  77. pmc The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus
    Bettina Schulthess
    Institute of Medical Microbiology, University of Zurich, Gloriastrasse 32, 8006 Zurich, Switzerland
    J Bacteriol 193:4954-62. 2011
    ..on a small subregulon encoding mainly virulence factors, including a nuclease (nuc), a protease (splE) and a lipase (lip)...
  78. ncbi The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
    Chih Wen Wang
    Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Liver Int 31:1326-31. 2011
    ..However, whether there is an association between PNPLA3 I148M and insulin resistance and NAFLD in a normoglycaemic population is still unknown...
  79. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
    ..We investigated mechanisms by which three perilipin proteins control lipolysis by adipocyte triglyceride lipase (ATGL), a key lipase in adipocytes and non-adipose cells...
  80. pmc Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae
    Sona Rajakumari
    Institute of Biochemistry, Graz University of Technology, A 8010 Graz, Austria
    J Biol Chem 285:15769-76. 2010
    ..Here, we demonstrated that the yeast TAG lipase Tgl4p, the functional ortholog of the adipose TAG lipase, ATGL, catalyzes multiple functions in lipid metabolism...
  81. pmc Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A
    Maria P Frushicheva
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 1062, USA
    Chembiochem 13:215-23. 2012
    ..by simulating the hydrolysis of enantiomers of an α-substituted ester by wild-type and mutant Candida antarctica lipase A, using several strategies...
  82. ncbi Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study
    Rolf V Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Am Coll Cardiol 41:1972-82. 2003
    We investigated associations between single nucleotide polymorphisms (SNPs) in the hepatic lipase promoter, levels of high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  83. ncbi Biodiesel production with immobilized lipase: A review
    Tianwei Tan
    Beijing Bioprocess Key Laboratory, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, PR China
    Biotechnol Adv 28:628-34. 2010
    ..Biodiesel is produced by transesterification of oils or fats with chemical catalysts or lipase. Immobilized lipase as the biocatalyst draws high attention because that process is "greener"...
  84. ncbi Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
    Thomas J Alsted
    University of Copenhagen, The August Krogh Bldg 13, Universitetsparken, DK, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 296:E445-53. 2009
    ..exercise training increases the lipolytic capacity of skeletal muscle, the expression of hormone-sensitive lipase (HSL) is not changed...
  85. pmc Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2
    Xin Lu
    Department of Pediatrics and the Kentucky Pediatric Research Institute, University of Kentucky, Lexington, KY, USA
    Cell Cycle 9:2719-25. 2010
    ..Adipose triglyceride lipase (ATGL) is the key enzyme for TAG hydrolysis (lipolysis) in adipocytes and LD degradation in nonadipocyte cells...
  86. pmc Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
    Veronic Bezaire
    INSERM U858, Laboratoire de recherches sur les obésités, F 31432 Toulouse, France
    J Biol Chem 284:18282-91. 2009
    Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) have the capacity to hydrolyze in vitro the first ester bond of triglycerides,..
  87. ncbi Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 282:996-1002. 2007
    ..regulate adipocyte lipolysis have relied on non-adipocyte cell models, which express neither adipose triglyceride lipase (ATGL), the rate-limiting enzyme for triglyceride catabolism in mice, nor the "downstream" lipase, hormone-..
  88. pmc PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 52:904-12. 2010
    ..We did not observe any association of this variant with body mass index, triglyceride levels, high- and low-density lipoprotein levels, or diabetes (P > 0.05). None of the variants at the other 6 loci were associated with NAFLD...
  89. pmc Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:S63-8. 2009
    ..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
  90. ncbi Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol
    Andrew S deLemos
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Circulation 106:1321-6. 2002
    ..Overexpression of endothelial lipase (EL), a member of the lipoprotein lipase gene family, markedly reduces HDL-C levels in mouse models...
  91. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
    A new lipoprotein lipase-like gene has been cloned from endothelial cells through a subtraction methodology aimed at characterizing genes that are expressed with in vitro differentiation of this cell type...
  92. ncbi Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis
    Tomoyuki Yasuda
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ J 74:2263-70. 2010
    Endothelial lipase (EL) is a phospholipase that belongs to the lipoprotein lipase (LPL) family, which includes LPL and hepatic lipase (HL)...
  93. pmc Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions
    Sona Rajakumari
    Institute of Biochemistry, Graz University of Technology, A 8010 Graz, Austria
    Mol Biol Cell 21:501-10. 2010
    ..Motif search analysis, however, indicated that Tgl3p and Tgl5p do not only contain the TAG lipase motif GXSXG but also an H-(X)(4)-D acyltransferase motif...
  94. ncbi Microbial lipases form versatile tools for biotechnology
    K E Jaeger
    Lehrstuhl Biologie der Mikroorganismen, Ruhr Universitat, Bochum, Germany
    Trends Biotechnol 16:396-403. 1998
    ..Immobilization in hydrophobic sol-gel matrices and in vitro evolution are promising novel approaches to increasing the stability or enantioselectivity, respectively, of lipases...
  95. pmc Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 284:34538-44. 2009
    ..and there is strong evidence that perilipin (Plin), a lipid droplet scaffold, and adipose tissue triglyceride lipase (Atgl), a triglyceride-specific lipase, play critical roles...
  96. ncbi Hepatic lipase: a marker for cardiovascular disease risk and response to therapy
    Alberto Zambon
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Curr Opin Lipidol 14:179-89. 2003
    Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties...
  97. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
    ..The first step of lipolysis (i.e. the mobilization of fat stores) is catalyzed by adipose triglyceride lipase (ATGL)...
  98. ncbi Hepatic lipase, lipoprotein metabolism, and atherogenesis
    Silvia Santamarina-Fojo
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 24:1750-4. 2004
    The role of hepatic lipase as a multifunctional protein that modulates lipoprotein metabolism and atherosclerosis has been extensively documented over the last decade...
  99. ncbi More stable structure of wheat germ lipase at low pH than its native state
    Ejaz Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    Biochimie 92:885-93. 2010
    Wheat germ lipase is a cereal lipase which is a monomeric protein. In the present study we sought to structurally characterize this protein along with equilibrium unfolding in solution...
  100. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
    ..05) compared with those values in whites. Irrespective of sex, higher postheparin plasma hepatic lipase (HL) and lower lipoprotein lipase (LPL) activities were found in whites, resulting in an HL/LPL ratio that was ..
  101. pmc Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
    ..haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL), consistent with its role in HDL-C catabolism...

Research Grants75

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..While 2-AG is degraded by multiple enzymes, recent evidence suggests a primary role for monoacylglycerol lipase (gene name MGLL)...
  2. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..We will employ Lrat-/- and Rbp-/- mice and mice expressing lipoprotein lipase (LpL) solely in skeletal muscle (MCK-LpL0 mice) to investigate these relationships...
  3. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Moreover, elevated Elovl5 activity induced adipocyte triglyceride lipase (ATGL), comparative gene identification-58 (CGI58, ATGL co-activator) and short &long chain acylcarnitines in ..
  4. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..drive) and from WAT, and two SNS-induced intracellular markers of lipolysis (phosphorylation of hormone sensitive lipase and perilipin A) by Western blot...
  5. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..The recent description of ectopic procolipase and pancreatic lipase related protein 2 (PLRP2) expression in the liver and other tissues when mice are kept in constant darkness raises ..
  6. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..uncover mechanisms of body weight regulation through a newly discovered pathway mediated by the enzyme lipoprotein lipase (LPL) in the neuron...
  7. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ..mice displayed severe hypertriglyceridemia secondary to inefficient TG clearance catalyzed by lipoprotein lipase (LPL)...
  8. Adiponectin and fetal programming
    Jianhua Shao; Fiscal Year: 2013
    ..Although there was no change in placenta mass, remarkably increased lipoprotein lipase (LPL) gene expressions were observed in placentas from obese dams...
  9. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..basal lipolysis, that ATMs are the primary source of both insulin-like growth factor-1 (Igf1) and lipoprotein lipase (Lpl) in obese adipose tissue and surprisingly that obesity rather then inducing a classical inflammatory program ..
  10. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..1) First, novel data in our lab has revealed an unexpected GEF activity that exists in the lipase PLD2...
  11. Regulation/Role of AcylCer in Normal Epidermis and Atopic Dermatitis
    Peter M Elias; Fiscal Year: 2013
    ..recently showed that both acyl-CoA wax alcohol acyltransferases (AWAT) 1 and CGI-58 (a cofactor of triacylglycerol lipase) are further required for w-O-esterification, leading to acylCer production...
  12. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..Subsequently we found that HCV- infected human hepatoma cells increased their expressions of hepatic lipase (HL) and lipoprotein lipase (LPL), both of which are key enzymes in maintaining circulating lipoprotein levels and ..
  13. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..Although monoacylglycerol lipase (MAGL) and fatty-acid amide hydrolase (FAAH) are known to catalyze the hydrolysis of 2AG and AEA, respectively, we ..
  14. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..in adipocytes;and b) determining whether GX sPLA2 promotes TAG mobilization by activating hormone sensitive lipase. Results from these studies have the potential to provide important insights into a novel mechanism regulating ..
  15. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..Angptl4 is a secreted glycoprotein that is a known inhibitor of lipoprotein lipase and increased plasma levels of this protein result in the development of hypertriglyceridemia (a component of ..
  16. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    ..acini and adipocytes functioned normally in this medium both individually and together in the presence of the lipase inhibitor orlistat, omission of orlistat resulted in near total acinar necrosis, as evidenced by propidium iodide ..
  17. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..in the fasted state, and impaired hydrolysis of VLDL- and chylomicron-TG, secondary to impaired lipoprotein lipase activity in the fed state, 2) hypercholesterolemia is in part due to impaired cholesterol transport to the liver ..
  18. Discovering tissue-specific biomarkers of radiation injury in SILAC-labeled mice
    Amanda G Paulovich; Fiscal Year: 2013
    ..the troponins in myocardial infarction, transaminases in liver injury, creatine kinase in muscle injury, and lipase in pancreatic processes...
  19. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..and mobilization will focus on the adipokinetic hormone (AKH;this portion has been completed) and Brummer (Bmm) lipase systems, as well as lipid transport by lipophorin (Lp) during the reproductive cycle...
  20. The Metabolic Impact of Congenital Heterozygous ApoC-III Deficiency in Humans
    TONI ILANA POLLIN; Fiscal Year: 2013
    ..8 kDa protein component of both triglyceride-rich lipoproteins (TRLs) and HDL particles, inhibits lipoprotein lipase activity and hepatic uptake of TRLs...
  21. Glucocorticoid Receptor and Lipid Homeostasis
    Jen Chywan Wang; Fiscal Year: 2013
    ..k.a angiopoietin-like 4, ANGPTL4), which encodes a secreted protein that inhibits lipoprotein lipase and induces adipose tissue lipolysis...
  22. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..Also, adiponectin infusion into pregnant rats caused a decrease in glucose transporter 3 and lipoprotein lipase (LPL) mRNA expression...
  23. Disordered Cellular Cholesterol Movement, Cell Death, and Multisystem Disease
    STEPHEN DEAN TURLEY; Fiscal Year: 2013
    ..through the late endosomal/lysosomal compartment of every cell where at least three proteins (lysosomal acid lipase, LAL;Niemann-Pick type C1, NPC1;and Niemann-Pick type C2, NPC2,) act in tandem to metabolize and move this sterol ..
  24. Perilipin and cellular triacylglycerol metabolism
    Dawn L Brasaemle; Fiscal Year: 2013
    ..CGI- 58, a Coenzyme A-dependent lysophosphatidic acid acyltransferase and co-activator of adipose triglyceride lipase (ATGL)...
  25. Inhibition of Fat Absorption as a Mechanism to Treat Obesity
    CHARLES MILTON MANSBACH; Fiscal Year: 2013
    ..Currently, a compound called tetrahydrolipstatin has been developed to inhibit pancreatic lipase, an enzyme required to break down dietary fat prior to its absorption...
  26. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..rescued by introducing second-site mutations in genes that increase TAG levels, such as the adipose triglyceride lipase gene or the adipokinetic hormone receptor gene (which acts like glucagon to drive lipolysis)...
  27. Insulin Resistance in Chronic Heart Failure: pathophysiology and potential for re
    Nir Uriel; Fiscal Year: 2013
    ..We will also measure post heparin plasma lipoprotein lipase (LPL) activity to assess the availability of circulating lipoprotein-derived FFA in each group of subjects...
  28. An investigation of the mechanisms by which down-regulation of lipoprotein lipase
    Jheem D Medh; Fiscal Year: 2013
    ..proposal is aimed at understanding the mechanisms and signaling pathways by which down- regulation of lipoprotein lipase (LPL) leads to improved insulin sensitivity in muscle cells...
  29. Adiponectin and Regulation of Triglyceride Metabolism
    Jianhua Shao; Fiscal Year: 2012
    ..Interestingly, postheparin plasma lipoprotein lipase (LPL) activity, as well as LPL and VLDL receptor gene expression in skeletal muscle, was significantly increased ..
  30. A Simple Cellular Model for Lipodystrophy
    Joel M Goodman; Fiscal Year: 2013
    ..We have found conditions in which the lipase Tgl3p and others require seipin for localization to droplets...
  31. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..to examine whether variations in the FAAH gene and the MGLL gene (for the rate limiting enzyme, monoacylglycerol lipase, for another endocannabinoid, 2-arachidonyl glycerol) influence the pharmacological effect of cannabinoid ..
  32. Stem Cell Models of Familial Combined Hypolipidemia
    Kiran Musunuru; Fiscal Year: 2013
    ..exclusively synthesized in liver and secreted into the bloodstream, has been reported to inhibit lipoprotein lipase (encoded by LPL) and endothelial lipase (encoded by LIPG), increasing plasma TG and HDL-C levels in rodents...
  33. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..also use mice lacking low density lipoprotein receptor (LDLr) or class B scavenger receptor (SR-BI) or lipoprotein lipase (LPL) to investigate the role of these key players of the lipid metabolism in facilitating the maternal-fetal ..
  34. LIPOLYSIS AND OLEOYLETHANOLAMIDE SIGNALING IN THE REGULATION OF LONGEVITY
    ANDREW K FOLICK; Fiscal Year: 2013
    ..Additionally, we have found that when we induce lipolysis by increasing expression of lipase genes, levels of the lipid messenger oleoylethanolamide (OEA) are increased. Oral administration of OEA to C...
  35. Apolipoprotein A-V: A Functional Proteomics Study
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..Whereas factors such as lipoprotein lipase and apolipoproteins C-II / C-III are known to modulate plasma TG levels, accumulating evidence suggests the ..
  36. FFA Production From Triglyceride-Rich Lipoproteins
    John M Miles; Fiscal Year: 2013
    ..FFAs are released into the blood through the action of hormone sensitive lipase on triglyceride stores in fat cells...
  37. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2012
    ..Preliminary results suggest that LPL34 contains lipase activity...
  38. Targeting Adipocyte Lipases to Treat Pancreatic Cancer-Associated Cachexia
    Enrique Saez; Fiscal Year: 2013
    ..Genetic ablation of adipose triglyceride lipase (ATGL) and to a lesser extent hormone sensitive lipase (HSL) can protect from cancer-associated cachexia, ..
  39. Engineering an in vitro model of adipose tissue formation and metabolism
    Kyongbum Lee; Fiscal Year: 2010
    ..initial knockdown targets are: glucose transporter GLUT4;lipogenic enzymes ACC, FAS and AWAT;and lipolysis enzyme lipase. Selection of these targets is based on an earlier study linking adipocyte hypertrophy with metabolic flux changes ..
  40. Lipid Signaling During Fertilization
    Bradley J Stith; Fiscal Year: 2010
    ..We will use proven methods to quantify (Kd) the affinity between LPA, PA and Src. We will alter lipase D activity (by use of constitutively active or dominant negative PLD) or morpholinos against Xenopus phospholipase ..
  41. Insulin-Like Growth Factor-1 and Atherosclerosis
    Patrice Delafontaine; Fiscal Year: 2013
    ..effects and in particular the roles of chemokine receptors (CCR1, CCR2) and of 12/15-lipoxygenase and lipoprotein lipase. Specific Aim 2: To demonstrate that IGF-1 increases atherosclerotic plaque stability and determine mechanisms...
  42. Pathophysiology of PPARgamma in the lung
    Hong Du; Fiscal Year: 2012
    ..MMP-12) and that this control derives from fatty acid ligands, generated in the lysosomes by lysosomal acid lipase (LAL)...
  43. Mobilization of Triacylglycerol Stores in Insects
    Estela L Arrese; Fiscal Year: 2012
    ..During the previous period we identified two key components of the lipolytic pathway in insects. The main lipase found in the insect fat body, TG-lipase (TGL) homolog to Drosophila melanogaster CG8552, and a lipid droplet-..
  44. Triglyceride Rich Lipoprotein Metabolism and Fatty Acid Selectivity
    ROBERT HENRY NELSON; Fiscal Year: 2012
    ..Oleate and palmitate generated by lipoprotein lipase lipolysis of circulating triglycerides spill over into the plasma free fatty acid pool more than linoleate. 2...
  45. Inhibition of ATGL-Mediated Lipolysis by G0S2
    Jun Liu; Fiscal Year: 2013
    ..FFAs and glycerol, has been a subject of intense investigation for decades, with much focus on hormone-sensitive lipase (HSL)...
  46. REGIONAL FATTY ACID METABOLISM IN HUMANS
    Michael D Jensen; Fiscal Year: 2013
    ..We found that direct storage of circulating FFA independent of lipoprotein lipase seems to best relate to body fat distribution...
  47. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..We have identified a novel animal model, the lipoprotein lipase-deficient (LPL-/-) cat, that will provide this essential data...
  48. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    ..very low density lipoprotein (VLDL) particles secreted from the liver, and is gradually hydrolyzed by lipoprotein lipase into muscle and adipose tissue capillary endothelia...
  49. Adipose Tissue Lipolysis and Alcoholic Fatty Liver
    Zhanxiang Zhou; Fiscal Year: 2013
    ..On the other hand, chronic alcohol exposure activated both hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) pathways in the adipose tissue, indicating an upregulation of ..
  50. Role of PPARalpha in acute kidney injury
    Didier Portilla; Fiscal Year: 2013
    ..mice and two animal models of renal fibrosis to determine if increased fatty acid oxidation, lipoprotein lipase activity, and increased autophagy contribute to reduced lipotoxicity and prevent proximal tubule cell death in ..
  51. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..this hypothesis, we will first use immunocytochemistry to ascertain that, as in adults, both CB1 receptors and DAG lipase are present in the dorsal horn of neonatal rats...
  52. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ..though the blockade of their respective catabolic enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) represents a promising therapeutic approach that lacks many of the undesirable side effects of direct-..
  53. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani V Subbaiah; Fiscal Year: 2012
    ..all enzymes that utilize PC as substrate will be tested with respect to secretory phospholipases and endothelial lipase. The inhibitory role of SM in the generation of pro-inflammatory oxidized PCs and oxysterols will be tested in ..
  54. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Monoglyceride lipase (MGL) degrades 2AG in vivo...
  55. Genetic Mechanisms in Borrelia burgdorferi Pathogenesis
    Jonathan T Skare; Fiscal Year: 2013
    ..These genes encode for an exported lipase (bb0646) and a serine/threonine kinase (bb0648), respectively, which we suggest are involved in the oxidative ..
  56. Hyperhomocysteinemia and HDL Metabolism
    Hong Wang; Fiscal Year: 2013
    ..HHcy is associated with increased HDL-C turnover and increased protein levels of hepatic/vascular endothelial lipase (EL), an HDL degradation enzyme in mice...
  57. The maternal-fetal adiponectin differential and fetal fat deposition
    Jianhua Shao; Fiscal Year: 2013
    ..levels of: 1) body fat;2) liver triglycerid content and expression of de novo lipogenic genes and 3) lipoprotein lipase (LPL) in fat tissue, compared with Adipoq-/- fetuses...
  58. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
    ..Hypertriglyceridemia is caused by inherited defects in lipoprotein lipase (LPL), but the etiology of most cases of hypertriglyceridemia remains mysterious...
  59. Adipose Triglyceride Lipase (ATGL) in Lipotoxicity and The Metabolic Syndrome
    Erin E Kershaw; Fiscal Year: 2013
    ..Adipose triglyceride lipase (ATGL) has recently been identified as the rate-limiting enzyme mediating TG hydrolysis, and is therefore a ..
  60. Transport of Lipoprotein Lipase by Heparan Sulfate Proteoglycans
    Jon C Gonzales; Fiscal Year: 2011
    Lipoprotein lipase is the critical enzyme responsible for the hydrolysis of triglyceride-rich lipoproteins in the peripheral circulation...
  61. LIPID SIGNALING IN REGULATION OF LONGEVITY
    MENG CARLA WANG; Fiscal Year: 2013
    ..b>Lipase-induced lipolysis is a canonical metabolic process to break down fat, which is recently shown to produce lipid ..
  62. Calcium-Independent PLA2Beta in Beta-Cell Apoptosis
    Sasanka Ramanadham; Fiscal Year: 2013
    ..The roles of lipid mediators, SREBPs, ROS, and GSH on iPLA2 and NSMase expression and the affects of mutating the lipase sequence in iPLA2 on ceramide generation will be examined...
  63. LINGUAL SEROUS GLANDS--REGULATION OF ENZYME SECRETION
    RUTH FIELD; Fiscal Year: 1992
    The aim of this study is to investigate the regulation of secretion of two digestive enzymes, lingual lipase and amylase, from serous (von Ebner's) glands of the tongue...
  64. PANCREATIC LIPASES AND COLIPASE IN LIPOLYSIS AND OBESITY
    Mark Lowe; Fiscal Year: 2007
    ..The Specific Aims in this grant are to: 1) Define the contribution of carboxyl ester lipase (CEL) and pancreatic lipase related protein 2 (PLRP2) to the digestion of dietary fat...
  65. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    The primary goal of this proposal is an understanding of the role of diacyglycerol lipase-a (DAGL) in the biosynthesis of the endogeneous cannabinoid 2-arachidonoylglycerol and the role of this enzyme in endocannabinoid signaling and ..
  66. MECHANISM OF DIETARY ADAPTATION OF PANCREATIC FUNCTION
    PATSY BRANNON; Fiscal Year: 1990
    ..protein result in adaptive changes in the synthesis, activity and mRNA levels of the pancreatic digestive enzymes: lipase, amylase, trypsinogen and chymotrypsinogen...
  67. Novel Anti-Obesity Drugs Targeting Fat Processing Pathway
    Henry Pelish; Fiscal Year: 2009
    ..The FDA-approved lipase inhibitor Orlistat prevents fat processing in the gut, leading to reduced body mass index in obese patients...
  68. STRUCTURE-FUNCTION ANALYSIS OF COLIPASE AND LIPASE
    Mark Lowe; Fiscal Year: 2005
    ..Lipases in the stomach and duodenum digest dietary fats. This proposal focuses on the lipase responsible for the majority of fat digestion, pancreatic triglyceride lipase, and another pancreatic protein, ..
  69. NOVEL PROTEASE FORMULATION BASED ON CROSSLINKED CRYSTALS
    Bhami Shenoy; Fiscal Year: 2004
    ..for use in the treatment of chronic abdominal pain in chronic pancreatitis and also along with TheraCLEC-Lipase and amylase for the treatment of malabsorption as a result of pancreatic insufficiency in cystic fibrosis and ..
  70. NUTRITION AND LIPOPROTEIN LIPASE-MOLECULAR MECHANISMS
    SUSAN FRIED; Fiscal Year: 1992
    ..is the rate of uptake of circulating triglycerides which is controlled by the activity of the enzyme lipoprotein lipase (LPL)...
  71. Resolutions in Branched Alkanes using Lipase in Beads
    STEVEN NEAU; Fiscal Year: 2002
    ..The proposed research incorporates lipase into these beads for easy recovery and subsequent delivery...
  72. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Our central hypothesis is that stress stimuli that result in nonopioid SIA activate diacylglycerol lipase (DGL) in select neurons of the PAG, causing the rapid mobilization of 2-AG...
  73. LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKE
    JOSEPH OBUNIKE; Fiscal Year: 1999
    Lipoprotein lipase (LPL) is the major enzyme responsible for hydrolysis of triglyceride (TG) molecules present in circulating lipoproteins...
  74. EFFECTS OF OMEGA-3 FATTY ACIDS ON LIPID TRANSPORT
    Andre Bensadoun; Fiscal Year: 1991
    ..is that w3 fatty acids when substituted for w6 fatty acids in membranes enhance the activity of lipoprotein lipase (LPL) and hepatic lipase (HL)...
  75. FUNCTION OF LIPOPROTEIN LIPASE PROTEOGLYCAN INTERACTION
    Andre Bensadoun; Fiscal Year: 2002
    Lipoprotein lipase(LPL) is the major enzyme responsible for the hydrolysis of plasma triglyceride rich lipoproteins...