glucose 6 phosphatase

Summary

Summary: An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.

Top Publications

  1. ncbi Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin
    S Song
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Am J Physiol Endocrinol Metab 281:E275-82. 2001
  2. ncbi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    Un Ju Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Korea
    J Nutr 134:2499-503. 2004
  3. pmc Glucose-6-phosphatase catalytic subunit gene family
    John C Hutton
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado 80045, USA
    J Biol Chem 284:29241-5. 2009
  4. ncbi Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes
    C C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Biol Chem 276:25197-207. 2001
  5. ncbi Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines
    R S Streeper
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 275:12108-18. 2000
  6. pmc Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells
    Jun Yamanouchi
    Julia McFarlane Diabetes Research Centre JMDRC and Department of Microbiology and Infectious Diseases, Institute for Infection, Immunity and Inflammation, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada
    Diabetes 59:272-81. 2010
  7. ncbi Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein
    S D Arden
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, UK
    Diabetes 48:531-42. 1999
  8. pmc Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2
    Amandine Gautier-Stein
    INSERM U 449, Faculte de Medecine Laennec, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Nucleic Acids Res 31:5238-46. 2003
  9. ncbi Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    A Christine Könner
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 5:438-49. 2007
  10. pmc Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes
    Bingye Han
    Department of Microbiology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 115:1879-87. 2005

Detail Information

Publications234 found, 100 shown here

  1. ncbi Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin
    S Song
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Am J Physiol Endocrinol Metab 281:E275-82. 2001
    ..Metformin predominantly inhibits alanine gluconeogenesis by preventing the fat-induced changes in fructose-1,6-bisphosphatase levels...
  2. ncbi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    Un Ju Jung
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Korea
    J Nutr 134:2499-503. 2004
    ....
  3. pmc Glucose-6-phosphatase catalytic subunit gene family
    John C Hutton
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado 80045, USA
    J Biol Chem 284:29241-5. 2009
    ..This minireview discusses the disease association and transcriptional regulation of the G6PC genes as well as the biological functions of the encoded proteins...
  4. ncbi Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes
    C C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Biol Chem 276:25197-207. 2001
    ..The results provide a framework for the further analysis of the molecular basis for the tissue-restricted expression of the IGRP gene and the identification of key amino acid sequences that determine its biological activity...
  5. ncbi Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines
    R S Streeper
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 275:12108-18. 2000
    ....
  6. pmc Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells
    Jun Yamanouchi
    Julia McFarlane Diabetes Research Centre JMDRC and Department of Microbiology and Infectious Diseases, Institute for Infection, Immunity and Inflammation, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada
    Diabetes 59:272-81. 2010
    ..1, Idd9.2, and Idd9.3), are strongly resistant to type 1 diabetes. However, the mechanisms remain unclear. This study aimed to define mechanisms underlying the type 1 diabetes resistance afforded by B10 Idd9.1, Idd9.2, and/or Idd9.3...
  7. ncbi Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein
    S D Arden
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, UK
    Diabetes 48:531-42. 1999
    ....
  8. pmc Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2
    Amandine Gautier-Stein
    INSERM U 449, Faculte de Medecine Laennec, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Nucleic Acids Res 31:5238-46. 2003
    ..They also suggest that CDX transactivation might be essential for intestine gene expression, irrespective of the presence of a functional TATA box...
  9. ncbi Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    A Christine Könner
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 5:438-49. 2007
    ..However, insulin action specifically in AgRP-expressing neurons does play a critical role in controlling hepatic glucose production and may provide a target for the treatment of insulin resistance in type 2 diabetes...
  10. pmc Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes
    Bingye Han
    Department of Microbiology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 115:1879-87. 2005
    ..These results illustrate the way in which incomplete deletion of autoreactive T cell populations of relatively high avidity can contribute to the development of pathogenic autoimmunity in the periphery...
  11. ncbi Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1
    Cyrus C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Biol Chem 279:34277-89. 2004
    ....
  12. ncbi New hepatic targets for glycaemic control in diabetes
    Loranne Agius
    Institute of Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Best Pract Res Clin Endocrinol Metab 21:587-605. 2007
    ..The advantage of combined targeting of two or more sites within the liver for minimizing side-effects and tachyphylaxis caused by single-site targeting is discussed...
  13. ncbi Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration
    T Taguchi
    Dept of Pathobiochemistry, Faculty of Pharmacy, Meijo Univ, 150 Yagotoyama, Tempaku ku, Nagoya 468 8503, Japan
    Am J Physiol Endocrinol Metab 288:E534-40. 2005
    ..When lactate was used to perfuse the liver of fasted rats, a decrease, rather than an increase, in mannose output was observed. These findings indicate that hepatic glycogen is a source of plasma mannose...
  14. ncbi Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines
    L J Bischof
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232-0615, USA
    Diabetes 50:502-14. 2001
    ..In addition, binding sites for several trans-acting factors not previously associated with islet gene expression, as well as binding sites for potentially novel proteins, were identified...
  15. pmc Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
    Balasubramanian Krishnamurthy
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Clin Invest 116:3258-65. 2006
    ..Our results suggest that pathogenic proinsulin-specific immunity in NOD mice subsequently spreads to other antigens such as IGRP...
  16. pmc Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
    Clara Kelliny
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 58:2939-45. 2009
    ..The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children...
  17. ncbi The molecular basis of glycogen storage disease type 1a: structure and function analysis of mutations in glucose-6-phosphatase
    Jeng Jer Shieh
    Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:5047-53. 2002
    ....
  18. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  19. pmc A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro
    Christine Dos Santos
    Department of Pediatric Endocrinology and U561 Institut National de Santé et de Recherche Médicale, Hopital Saint Vincent de Paul, Paris, France
    Diabetes 58:489-92. 2009
    ..We tested the cis-regulatory effects of rs573225 on promoter activity and its association with insulin response to oral glucose...
  20. ncbi Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein
    C C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Mol Endocrinol 29:205-22. 2002
    ..In contrast to the G6Pase catalytic subunit gene promoter, the UGRP promoter was highly active in all cell lines examined...
  21. ncbi Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
    F Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Diabetologia 53:299-308. 2010
    ..To test fasting glucose association at four loci recently identified or verified by genome-wide association (GWA) studies of European populations, we performed a replication study in two Asian populations...
  22. ncbi Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene
    D H Ebert
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232 0615, USA
    Diabetes 48:543-51. 1999
    ..The IGRP and G-6-Pase catalytic subunit gene promoters show a reciprocal pattern of activity, with the IGRP promoter being approximately 150-fold more active than the G-6-Pase promoter in HIT cells...
  23. ncbi A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
    C S Rose
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 52:2122-9. 2009
    ..Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome...
  24. ncbi Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype
    Y Wang
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 761 PRB, Nashville, TN, 37232 0615, USA
    Diabetologia 50:774-8. 2007
    ..However, since the function of G6PC2 is unclear, the concern with such an approach is that a change in G6PC2 expression might itself have deleterious consequences...
  25. ncbi Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo
    Yingda Wang
    Department of Molecular Physiology and Biophysics, 761 PRB, Vanderbilt University Medical School, Nashville, TN 37232 0615, USA
    Diabetes 57:133-41. 2008
    ..This study describes the use of a combination of transgenic and transfection approaches to characterize the gene regions that confer the islet-specific expression of IGRP...
  26. pmc Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk
    E Reiling
    Department of Molecular Cell Biology, Leiden University Medical Centre, PO Box 9600, 2300RC, Leiden, The Netherlands
    Diabetologia 52:1866-70. 2009
    ..variation in the genes for glucokinase (GCK), glucokinase regulatory protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG...
  27. pmc Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression
    Cyrus C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 8415 MRB IV, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
    J Mol Endocrinol 41:315-28. 2008
    ..These data suggest that the same group of islet-enriched transcription factors, namely Pdx-1, Pax-6, MafA, BETA2, and Foxa2, directly or indirectly regulate expression of the two major autoantigens in type 1 diabetes...
  28. ncbi A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France
    Science 320:1085-8. 2008
    ..We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells...
  29. pmc Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells
    D Schmoll
    Department of Biochemistry, University of Greifswald, D 17487 Greifswald, Germany
    Biochem J 338:457-63. 1999
    ....
  30. ncbi The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct
    Beth T Vander Kooi
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 278:11782-93. 2003
    ....
  31. pmc Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
    Scott M Lieberman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:8384-8. 2003
    ..The human IGRP gene maps to a diabetes susceptibility locus, suggesting that IGRP also may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target for diagnostic and therapeutic approaches...
  32. ncbi A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population
    C Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai, 200233, People s Republic of China
    Diabetologia 52:451-6. 2009
    ..The aim of this study was to investigate the effect of common variants of G6PC2 on type 2 diabetes and related clinical features in a Chinese population...
  33. ncbi Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP)
    Anthony J Petrolonis
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 279:13976-83. 2004
    ..IGRP inhibitors may be an attractive new approach for the treatment of insulin secretion defects in type 2 diabetes...
  34. ncbi Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade
    Ryo Yamashita
    Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Japan
    Endocr J 51:243-51. 2004
    ..These results suggest that aldosterone may affect the inhibitory effect of insulin on hepatic gluconeogenesis through the glucocorticoid receptor, which may be one of the causes of impaired glucose metabolism in primary aldosteronism...
  35. ncbi Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Comp Biochem Physiol C Toxicol Pharmacol 143:225-31. 2006
    ..87 +/- 30.62 mU/mg protein) in the same woodchuck model of HCC (P < 0.01). Our study demonstrated an increased HK activity and a decreased G6Pase activity in liver of the woodchuck models of HCC as compared to normal woodchuck liver...
  36. pmc Identification of novel IGRP epitopes targeted in type 1 diabetes patients
    Irene Jarchum
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Immunol 127:359-65. 2008
    ....
  37. pmc High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes
    B A Haber
    Department of Genetics, Children s Hospital of Philadelphia, Pennsylvania
    J Clin Invest 95:832-41. 1995
    ..The elevation of G6Pase expression in these conditions is indicative of its importance as a regulator of glucose homeostasis in normal and abnormal physiologic states...
  38. ncbi In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity
    J J Shieh
    Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Diabetologia 48:1851-9. 2005
    ..We therefore investigated the molecular events that inactivate IGRP activity and the effects of the beta cell antigen sequence on the stability and enzymatic activity of G6Pase-alpha...
  39. ncbi Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin
    Hiroshi Onuma
    Department of Molecular Physiology and Biophysics, 761 Preston Research Building, Vanderbilt University Medical School, Nashville, Tennessee 37232 0615, USA
    Mol Endocrinol 20:2831-47. 2006
    ....
  40. pmc A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes
    John C Hutton
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:8626-8. 2003
  41. ncbi Cloning and sequencing of the 5' region of the human glucose-6-phosphatase gene: transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells
    D Schmoll
    Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, University of Dundee, UK
    FEBS Lett 383:63-6. 1996
    ..Dexamethasone increased and insulin decreased luciferase activity. Insulin and dibutyryl cyclic AMP both significantly decreased activity in the presence of dexamethasone...
  42. ncbi Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo
    L A Hornbuckle
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 281:E713-25. 2001
    ..These results suggest that the relative control strengths of the G-6-Pase catalytic subunit and G-6-P transporter in the G-6-Pase reaction are likely to vary depending on the in vivo environment...
  43. ncbi Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription
    R S Streeper
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 276:19111-8. 2001
    ..These results suggest that the stimulatory effect of PKA on G6Pase fusion gene transcription in HepG2 cells may be mediated in part by the phosphorylation of HNF-6...
  44. ncbi Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice
    Terry G J Derks
    Department of Pediatrics, Laboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 47:1032-42. 2008
    ..Glucokinase and pyruvate kinase mRNA levels were significantly decreased, whereas pyruvate dehydrogenase kinase isozyme 4 expression was increased 30-fold; this suggested decreased glycolytic activity...
  45. pmc Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose
    Silvia Marin
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques 1, Barcelona 08028, Spain
    Biochem J 381:287-94. 2004
    ..Interaction between metabolic intermediates and glycolytic/gluconeogenic pathways is a basic element of cross-talk in hepatocytes, and may explain some of the difficulties in genotype and phenotype correlation...
  46. ncbi Effect of corosolic acid on gluconeogenesis in rat liver
    Kotaro Yamada
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes Res Clin Pract 80:48-55. 2008
    ..These effects on hepatic glucose metabolism may underlie the various anti-diabetic actions of CRA...
  47. ncbi Hypothalamic responses to long-chain fatty acids are nutritionally regulated
    Kimyata Morgan
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:31139-48. 2004
    ..The lack of hypothalamic responses to oleic acid following short term overfeeding is likely to contribute to the rapid onset of weight gain and hepatic insulin resistance in this animal model...
  48. ncbi Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats
    L Pari
    Department of Biochemistry, Faculty of Science, Annamalai University, Tamil Nadu, India
    Diabetes Obes Metab 6:286-92. 2004
    ..The present study was designed to investigate the effect of diasulin, a polyherbal drug, on blood glucose, plasma insulin and the activities of hepatic glucose metabolic enzymes in alloxan-induced diabetic rats...
  49. ncbi Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia
    Bruna Kempfer Bassoli
    Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil
    Cell Biochem Funct 26:320-8. 2008
    ....
  50. ncbi Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation
    Patricia Vuguin
    Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:2617-22. 2004
    ....
  51. ncbi Regulation of fasted blood glucose by resistin
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1195-8. 2004
    ..Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity...
  52. doi Signal transduction. Sweet conundrum
    Morris J Birnbaum
    Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 319:1348-9. 2008
  53. ncbi Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production
    Mary E Waltner-Law
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 277:34933-40. 2002
    ..These results demonstrate that changes in the redox state may have beneficial effects for the treatment of diabetes and suggest a potential role for EGCG, or derivatives, as an antidiabetic agent...
  54. ncbi [Thyroid hormone and glucose metabolism]
    Nobuaki Kuzuya
    Department of Endocrinology and Metabolism, International Medical Center of Japan
    Nihon Rinsho 60:666-72. 2002
  55. ncbi Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites
    Tony K T Lam
    Department of Physiology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Am J Physiol Endocrinol Metab 284:E281-90. 2003
    ....
  56. ncbi Effect of partial substitution of dietary protein by a single gluconeogenic dispensable amino acid on hepatic glucose metabolism in rainbow trout (Oncorhynchus mykiss)
    S Kirchner
    Laboratory of Fish Nutrition, INRA Ifremer, 64310, St Pée sur Nivelle, France
    Comp Biochem Physiol A Mol Integr Physiol 134:337-47. 2003
    ..In conclusion, an excess of dietary DAA tested does not seem to modify glycemia or to have a negative impact on dietary carbohydrate utilization in rainbow trout...
  57. ncbi Rearing temperature enhances hepatic glucokinase but not glucose-6-phosphatase activities in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata) juveniles fed with the same level of glucose
    P Enes
    Departamento de Zoologia e Antropologia, Faculdade de Ciencias, Universidade do Porto, 4099 002 Porto, Portugal
    Comp Biochem Physiol A Mol Integr Physiol 150:355-8. 2008
    ..Within limits, increasing water temperature enhances liver GK but not G6Pase activities, suggesting that both species are more able to use dietary carbohydrates at higher rearing temperatures...
  58. ncbi Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats
    Akio Kuroda
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Metabolism 52:203-8. 2003
    ..57 +/- 0.33 v 1.03 +/- 0.17, P <.05). We conclude that BDNF mainly improves hepatic insulin resistance in obese insulin-resistant rats, probably by affecting the hepatic GK flux...
  59. ncbi Effect of biotin treatment on hepatic gene expression in streptozotocin-induced diabetic rats
    Yumi Sugita
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
    Biosci Biotechnol Biochem 72:1290-8. 2008
    ..These results indicate that biotin repressed the gluconeogenic genes and their transcription factors via a pathway independent of insulin-signaling and could improve the diabetic condition...
  60. ncbi Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats
    Rajendran Ananthan
    Department of Botany, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
    J Med Food 6:43-9. 2003
    ..This clearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide...
  61. ncbi Effect of fasting on carbohydrate metabolism in frugivorous bats (Artibeus lituratus and Artibeus jamaicensis)
    Eliana C Pinheiro
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia UnB, Brasilia DF, Brazil
    Comp Biochem Physiol B Biochem Mol Biol 143:279-84. 2006
    ..During short periods of fasting liver glycogenolysis seems to be the main responsible for the maintenance of glycemia...
  62. ncbi Hexachlorobenzene impairs glucose metabolism in a rat model of porphyria cutanea tarda: a mechanistic approach
    Marta Blanca Mazzetti
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428BGA, Ciudad Autonoma Buenos Aires, Argentina
    Arch Toxicol 78:25-33. 2004
    ..These results contribute to our understanding of the protective and modulatory effect that diets rich in carbohydrates have in hepatic porphyria disease...
  63. ncbi Low protein intake is associated with reduced hepatic gluconeogenic enzyme expression in rainbow trout (Oncorhynchus mykiss)
    Séverine Kirchner
    Laboratory of Fish Nutrition, INRA Ifremer, 64310 St Pée sur Nivelle, France
    J Nutr 133:2561-4. 2003
    ..The effect of dietary protein on low carbohydrate utilization in this species remains unclear...
  64. ncbi Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice
    M S Choi
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Diabetes Metab Res Rev 24:74-81. 2008
    ..This study investigated the beneficial effects of genistein and daidzein on IDDM, an autoimmune disease...
  65. ncbi Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling
    Gianluca Canettieri
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell Metab 2:331-8. 2005
    ..By stimulating the expression of IRS2 in conjunction with gluconeogenic genes, the CREB:TORC2 pathway thus triggers a feedback response that limits glucose output from the liver during fasting...
  66. ncbi p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
    Wenhong Cao
    Endocrine Biology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:42731-7. 2005
    ....
  67. ncbi Chlorpyrifos-induced alterations in the activities of carbohydrate metabolizing enzymes in rat liver: the role of zinc
    Ajay Goel
    Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India
    Toxicol Lett 163:235-41. 2006
    ..Hence, the present study clearly suggests that zinc plays an important role in regulating the hepatic activities of the enzymes involved in carbohydrate metabolism under conditions of chlorpyrifos toxicity...
  68. ncbi For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex
    Alex J Lange
    Am J Physiol Regul Integr Comp Physiol 292:R1379-80. 2007
  69. ncbi Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?
    Dalila Azzout-Marniche
    INRA, AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, Paris, F75005, France
    Am J Physiol Regul Integr Comp Physiol 292:R1400-7. 2007
    ..Moreover, the main glucose-6-phosphatase (G6Pase) isoform expressed in the small intestine is the ubiquitous isoform of G6Pase (G6PC3) rather than the G6PC1 isoform expressed in gluconeogenic organs...
  70. ncbi Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    Fabrizio Andreelli
    Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Rene Descartes Paris 5, France
    Endocrinology 147:2432-41. 2006
    ..We also demonstrate that regulation of hepatic glucose production by leptin and adiponectin, but not insulin, requires hepatic AMPKalpha2 activity...
  71. ncbi Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats
    Yuka Fujimoto
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Diabetes 55:2479-90. 2006
    ..Glucotoxicity may result in the blunted response of hepatic glucose flux to elevated plasma glucose and/or insulin associated with impaired regulation of GK by GKRP in ZDF rats...
  72. ncbi Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia
    Chaodong Wu
    Dept of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 291:E536-43. 2006
    ..Taken together, the present study demonstrates that perturbation of glucose flux in the liver plays a predominant role in the development of a diabetic phenotype, as characterized by hepatic insulin resistance...
  73. ncbi Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes
    P Stanley Mainzen Prince
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    J Biochem Mol Toxicol 20:96-102. 2006
    ..Combined, these results show that rutin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats...
  74. ncbi A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes
    Jun Seop Shin
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, TN 37232 0615, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1381-90. 2007
    ..9 +/- 4 mumol glucose/g liver). The decreased glucose effectiveness to suppress EGP and stimulate hepatic glucose uptake may result from failure of the sugar to activate GK by stimulating the translocation of the enzyme...
  75. ncbi Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency
    Tomoko Inubushi
    Tokushima Bunri University, Faculty of Life Science, Tokushima 770 8514, Japan
    Biofactors 23:59-67. 2005
    ..These results suggest that the pellagrous lesions in vitamin B6-deficiency are caused by an impaired synthesis of proline from ornithine, which results in the suppression of collagen neogenesis in the skin...
  76. ncbi Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  77. ncbi Glucose homeostasis in the newborn
    Robert Hume
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY Scotland, UK
    Early Hum Dev 81:95-101. 2005
    ..Hormonal dysfunctions in preterm infants may contribute to failures in postnatal expression of hepatic enzymes...
  78. ncbi Antidiabetic activity of Momordica charantia seeds on streptozotocin induced diabetic rats
    D Sathish Sekar
    Department of Biochemistry and Molecular Biology, University of Madras, India
    Pharmazie 60:383-7. 2005
    ..These results clearly show the antidiabetic properties of Momordica charantia. Both the varieties showed safe and significant hypoglycemic effects which were more pronounced in MCSEt1 compared to MCSEt2 and glibenclamide...
  79. ncbi Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
    Masako Doi
    Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Naruto, Tokushima 772 8601, Japan
    Am J Physiol Endocrinol Metab 292:E1683-93. 2007
    ..In conclusion, isoleucine administration stimulates both glucose uptake in the muscle and whole body glucose oxidation, in addition to depressing gluconeogenesis in the liver, thereby leading to the hypoglycemic effect in rats...
  80. ncbi The role of hepatic, renal and intestinal gluconeogenic enzymes in glucose homeostasis of juvenile rainbow trout
    Séverine Kirchner
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey UMDNJ, New Jersey Medical School, Newark, 07103 2714, USA
    J Comp Physiol B 178:429-38. 2008
    ....
  81. ncbi Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling
    Charles Y Cho
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cell Metab 3:367-78. 2006
    ..These data implicate PTP-MEG2 as a mediator of blood glucose homeostasis through antagonism of insulin signaling, and suggest that modulation of PTP-MEG2 activity may be an effective strategy in the treatment of type 2 diabetes...
  82. ncbi Regulation of blood glucose by hypothalamic pyruvate metabolism
    Tony K T Lam
    Departments of Medicine and Molecular Pharmacology, Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 309:943-7. 2005
    ..Thus, interventions designed to enhance the hypothalamic sensing of glucose may improve glucose homeostasis in diabetes...
  83. ncbi Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha
    Jianqi Yang
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 280:38689-99. 2005
    ..These findings demonstrate that C/EBPalpha is essential for the survival of animals during postnatal life and that its ablation leads to distinct biphasic change in metabolic processes...
  84. pmc Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3
    Christopher Lipina
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    Biochem J 392:633-9. 2005
    ..We suggest for the first time that although pharmacological inhibition of GSK3 reduces hepatic glucose production even in insulin-resistant states, feeding can repress the gluconeogenic genes without inhibiting GSK3...
  85. ncbi Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats
    L Pari
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India
    Life Sci 79:641-5. 2006
    ..A comparison was made between the action of pterostilbene and the antidiabetic drug--metformin...
  86. ncbi The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin-diabetic rats
    P N Pushparaj
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
    Life Sci 70:535-47. 2001
    ..These results indicate that AF is more potent than BuF in the amelioration of hyperglycemia in STZ-diabetic rats and is a potential source for the isolation of new orally active agent(s) for anti-diabetic therapy...
  87. ncbi Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats
    Ramin Alemzadeh
    Department of Pediatrics, University of Tennessee, Graduate School of Medicine, Knoxville, USA
    Eur J Endocrinol 146:871-9. 2002
    ..Since the liver plays a central role in glucose homeostasis, we studied the effect of chronic insulin suppression on key insulin-sensitive enzymes regulating hepatic gluconeogenesis...
  88. ncbi Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression
    Claude Kohl
    Endocrinologie et Metabolisme, Institut Cochin, INSERM U567, Paris, France
    Diabetes 51:2363-8. 2002
    ..In conclusion, this work suggests that benfluorex mainly via S 422-1 reduces gluconeogenesis by affecting gene expression and metabolic status of hepatocytes...
  89. ncbi The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic gluconeogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice
    H Kodama
    Basic Research Group, Tsukuba Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Ibaraki, Japan
    Jpn J Pharmacol 66:281-7. 1994
    ..Glucagon presumably activates the hepatic gluconeogenic enzymes to enhance hepatic glucose output...
  90. ncbi Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression
    Yongjun Tan
    University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607 7170, USA
    Hepatology 35:30-9. 2002
    ....
  91. ncbi Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats
    S Renee Commerford
    Exercise Science Research Institute, Arizona State University, Tempe, Arizona 85287, USA
    Am J Physiol Endocrinol Metab 283:E545-55. 2002
    ..Thus short-term, chronic exposure to HSD and HFD increase in vivo gluconeogenesis and the G-6-Pase catalytic subunit. Exposure to HSD diet also leads to adaptations in glucose phosphorylation and GK translocation...
  92. pmc Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate
    J M Wimhurst
    Biochem J 134:143-56. 1973
    ..Lipid was found to increase only in the experiments with high fructose concentrations. 7. Perfusion with either fructose or glucose decreased the rates of ureogenesis; addition of cycloheximide increased urea efflux from the liver...
  93. ncbi Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet
    Gilles Mithieux
    Institut National de la Sante et de la Recherche Medicale, Units 449, Faculte de Medecine Laennec, Lyon, France Merck Lipha, Lyon, France
    Diabetes 51:139-43. 2002
    ..Additional mechanisms might involve the diversion of glucose-6 phosphate into the pentose phosphate pathway and an inhibition of hepatic lactate uptake...
  94. ncbi Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes
    J Raju
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada
    Mol Cell Biochem 224:45-51. 2001
    ..These biochemical effects exerted by Trigonella seeds make it a possible new therapeutic in type-1 diabetes...
  95. ncbi Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction
    Sean W Limesand
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Endocrinol Metab 293:E1716-25. 2007
    ....
  96. ncbi Three-dimensional high voltage electron microscopy of thick biological specimens
    T Nagata
    Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Matsumoto, Japan
    Micron 32:387-404. 2001
    ..Overall, these procedures are useful for analyzing stereologically the ultrastructure of cell organelles in cells and tissues...
  97. ncbi Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides)
    Marie A McAnuff-Harding
    Department of Basic Medical Sciences, Biochemistry Section, University of the West Indies, Mona, Kingston 7, Jamaica
    Life Sci 78:2595-600. 2006
    ....
  98. ncbi The transcription factor CCAAT/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes
    C Arizmendi
    Department of Biochemistry and Molecular Biology, University of Salamanca School of Medicine, Salamanca E 37007, Spain
    J Biol Chem 274:13033-40. 1999
    ..These results link C/EBPbeta to the metabolic and gene regulatory responses to diabetes and implicate C/EBPbeta as an essential factor underlying glucocorticoid-dependent activation of PEPCK gene transcription in the intact animal...
  99. pmc Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element
    David Finlay
    Department of Pathology and Neurosciences, University of Dundee, Ninewells Medical School and Hospital, Dundee, DD1 9SY United Kingdom
    BMC Mol Biol 5:15. 2004
    ..We have shown previously that inhibitors of GSK-3 reduce the activity of two TIRE-containing gene promoters (PEPCK and G6Pase), whose products are required for gluconeogenesis...
  100. ncbi Modulation of key enzymes of glycolysis, gluconeogenesis, amino acid catabolism, and TCA cycle of the tropical freshwater fish Labeo rohita fed gelatinized and non-gelatinized starch diet
    Vikas Kumar
    Department of Aquaculture System and Animal Nutrition in the Tropics and Subtropics 480b, University of Hohenheim, Stuttgart, Germany
    Fish Physiol Biochem 36:491-9. 2010
    ....
  101. ncbi L-leucine, L-methionine, and L-lysine are involved in the regulation of intermediary metabolism-related gene expression in rainbow trout hepatocytes
    Marine Lansard
    INRA, UMR1067 Nutrition Aquaculture et Génomique, Pôle d Hydrobiologie, CD918, F 64310 St Pée sur Nivelle, France
    J Nutr 141:75-80. 2011
    ..These findings are particularly relevant regarding the involvement of amino acids in the regulation of metabolism-related gene expression...

Research Grants52

  1. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
  2. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..abstract_text> ..
  3. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    ....
  4. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..We are confident that the proposed studies will provide a new approach for effective treatment of O/MS and T2DM. ..
  5. Characterization of Effects of G6PC2 Gene Variants on Transcription and Splicing
    RICHARD M O apos BRIEN; Fiscal Year: 2010
    ..In addition, our sequence analyses suggest that the G6PC2 SNP that was first linked to variations in fasting blood glucose is located in a branch point, a key cis-acting element controlling pre-mRNA splicing. ..
  6. Notch1-FoxO1 interaction in regulation of hepatic gluconeogenesis
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2010
    ..Through genetic manipulation ofthe Notch pathway in mice, we hope to provide evidence that inhibition of Notch signaling in liver can lead to improved glycemic control. ..
  7. Regulation of Insulin Secretion by G6PC2
    RICHARD M O'BRIEN; Fiscal Year: 2013
    ..Aim I explores the function of G6pc2 at a molecular level whereas Aim 2 explores the physiological importance of the Gck/G6pc2 futile cycle for the attenuation of insulin secretion during exercise. ..
  8. The Role of IGRP in the Pathogenesis of Type 1 Diabetes
    RICHARD M O apos BRIEN; Fiscal Year: 2010
    ..Relevance: A protein called IGRP has been implicated in the development of type 1 diabetes. This project will assess whether the absence of IGRP in mice is sufficient to preven the onset of diabetes. ..
  9. METABOLIC HOMEOSTASIS IN LIVER REGENERATION
    LINDA GREENBAUM; Fiscal Year: 1999
    ....
  10. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ....
  11. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  12. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
    ..abstract_text> ..
  13. CONTROL MECHANISMS OF HEPATIC GLUCOSE OUTPUT
    John Clore; Fiscal Year: 2000
    ..Based on the novel observation that etomoxir (an inhibitor of FFA oxidation) inhibits G6Pase gene expression in nondiabetic animals, studies are described to examine the role of FFA on G6Pase gene expression and enzyme activity in vivo. ..
  14. PATHOBIOLOGY AND GENE TRANSFER IN CARDIOVASCULAR DISEASE
    Lawrence Chan; Fiscal Year: 2007
    ..that will be tested in LDLR-deficient mice and rhesus monkeys, and to test the efficacy and toxicity of a glucose 6 phosphatase (G6Pase) HD-Ad for the treatment of glycogen storage disease 1a (GSD-1a) in mice and dogs (using a GSD-1a ..
  15. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  16. GLYCOGEN STORAGE DISEASE TREATMENT: HEPATIC GENE THERAPY
    Barry Byrne; Fiscal Year: 2002
    ..These studies will yield important new information in establishing a clinically relevant treatment for these fatal diseases and add new understanding to the basic pathophysiology of GSD. ..
  17. PROGNOSIS IN GLYCOGENOSIS
    Barbara Brown; Fiscal Year: 1980
    ....
  18. SLC2A9, A Candidate ER GLUT in Normal and Cancer Cells
    Jeffrey Moley; Fiscal Year: 2002
    ..Identification of SLC2A9 as the endoplasmic reticulum glucose transporter will improve understanding of GSDs, and of glucose metabolism in benign and malignant tissues. ..
  19. Regulation of IGRP Gene Expression
    RICHARD O BRIEN; Fiscal Year: 2007
    ..And in Aim 4 we will compare the developmental expression of the endogenous IGRP gene with that of the -911 IGRP-betaa galactosidase transgene. ..
  20. DIETARY NUTRIENTS AS MODULATORS OF HEPATIC METABOLISM
    Michael Pagliassotti; Fiscal Year: 2001
    ..Finally, to explain the decreased Km of G-6Pase for G6P during HS diet, and increased Vmax during HF diet, kinetics of this enzyme will be measured in the intact and disrupted microsomes. ..
  21. REGULATION OF GLUCOSE-6-PHOSPHATASE GENE EXPRESSION
    RICHARD O BRIEN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
    ..abstract_text> ..
  23. The Role of 11beta-HSD1 in Type II Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  24. Gene delivery to striated muscle by systemic AAV vectors
    Dwight D Koeberl; Fiscal Year: 2010
    ..Efficacious muscle-targeted gene therapy in GSD-II will have implications for gene therapy in other muscular dystrophies and myopathies. ..
  25. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..Understanding the contributions of diabetes modifying genes in the extended mouse MIHC may identify human HLA orthologs whose presence has recently been established. ..
  26. ANTIGEN PRESENTING CELL DEFECTS IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 2009
    ..Successful completion of our proposed studies might ultimately provide means for preventing the development of this devastating disease. ..
  27. Sterol Metabolism in Pneumocystis
    EDNA KANESHIRO; Fiscal Year: 2009
    ....
  28. ABI Genetic Analyzer-DNA Sequencer 3100
    John Hutton; Fiscal Year: 2002
    ..Sussel and J. Hutton), two user representatives (one BDC and one non-BDC), and the core manager (S. Hawkes) will provide a balanced management policy for all users. ..
  29. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..The findings will have ramifications for public health, for the packaging trade and for the chemical industry. ..
  30. BIOLOGICALLY BASED CANCER RISK ASSESSMENT FOR MIXTURES
    E Luebeck; Fiscal Year: 2001
    ..To evaluate the usefulness of the TEF approach we propose to analyze the Allegheny/non-Allegheny coke oven cohort data, as an example. ..
  31. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
    ..These comparisons will guide preclinical experiments to further immunomodulatory gene therapy in Pompe disease and other lysosomal storage disorders. ..
  32. Transcription Factors in Neuroendocrine Differentiation
    Michael Lan; Fiscal Year: 2009
    ..Results from this study should help us to define the interplay between the IA-1 zinc-finger transcription factor and other neuroendocrine-specific transcription factors in pancreatic endocrine and neuronal development. ..
  33. Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)
    David Serreze; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Vesicular traffic and regulated secretion in C. elegans
    John Hutton; Fiscal Year: 2002
    ....
  35. Western Region Islet Study Group
    John Hutton; Fiscal Year: 2002
    ..abstract_text> ..
  36. REGULATION/INSULIN SECRETION BY PROTEIN PHOSPHORYLATION
    John Hutton; Fiscal Year: 2003
    ..Phogrin is of additional interest in type 1 diabetes as it is a major autoantigen. ..
  37. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
    ..The meeting is planned for 200 participants. Because of limited seating capacity in The Jackson Laboratory's auditorium, the meeting venue will be the Bar Harbor Regency Hotel, where participants will be housed and fed. ..
  38. CONFERENCE ON DIABETES MELLITUS
    Morris Birnbaum; Fiscal Year: 2004
    ..3) the relationship between specialized metabolic regulation and such generalized processes as proliferation, differentiation, apoptosis growth, and 3) molecular determinants in the neuronal control of appetite, growth and metabolism ..
  39. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2005
    ..These latter investigations are of particular importance in view of an ongoing NIDDK trial to prevent T1D in humans deemed at high risk by oral insulin treatment. ..
  40. MOLECULAR MECHANISM IN TYPE III GLYCOGEN STORAGE DISEASE
    Yuan Tsong Chen; Fiscal Year: 2002
    ....
  41. NINTH INTERNATIONAL WORKSHOPS ON OPPORTUNISTIC PEOTISTS (IWOP-9)
    EDNA KANESHIRO; Fiscal Year: 2006
    ..As in several IWOP meetings in the past, the 2006 Workshops will be held jointly with the annual meetings of the International Society of Protistologists ( formerly Society of Protozoologists). ..
  42. Pneumocystis Biochemistry: Ubiquinones
    EDNA KANESHIRO; Fiscal Year: 2002
    ..carinii CoQ biosynthesis and growth in axenic cultures, and (4) develop atovaquone-resistant P. carinii populations to evaluate CoQ synthesis in sensitive and resistant organisms. ..
  43. Institutional Clinical /Translational Science Awards
    John Clore; Fiscal Year: 2006
    ..Formal process and summative evaluation will ensure that planning milestones are met in preparation for submission of the U54 proposal. [unreadable] [unreadable] [unreadable]..
  44. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
    ....
  45. Leptin Production and Action in Adipocytes
    Yiying Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  46. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  47. MSM Scales of carcinogenesis: cells, crypts and cancer
    E Luebeck; Fiscal Year: 2007
    ..This includes consequences for cancer screening, early detection, and the testing of specific intervention and prevention strategies. [unreadable] [unreadable]..
  48. Western Region Islet Study Group
    John Hutton; Fiscal Year: 2007
    ..abstract_text> ..
  49. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
    ..Collectively, these studies will permit genetic and metabolic characterization of key events in the transition from simple obesity to diabesity in thee novel mouse models. ..