pancreatin

Summary

Summary: A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.

Top Publications

  1. ncbi Mismatch of duodenal deliveries of dietary fat and pancreatin from enterically coated microspheres
    J H Meyer
    Department of Medicine, Sepulveda VA Medical Center, California, USA
    Pancreas 15:226-35. 1997
  2. ncbi Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
  3. ncbi A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency
    U Halm
    Department of Internal Medicine II, University of Leipzig, Germany
    Aliment Pharmacol Ther 13:951-7. 1999
  4. ncbi A 2-year post-authorization safety study of high-strength pancreatic enzyme replacement therapy (pancreatin 40,000) in cystic fibrosis
    James M Littlewood
    UK Cystic Fibrosis Trust, 11 London Road, Bromley, Kent BR1 1BY, UK
    Expert Opin Drug Saf 10:197-203. 2011
  5. ncbi Prognostic factors in canine exocrine pancreatic insufficiency: prolonged survival is likely if clinical remission is achieved
    Daniel J Batchelor
    Small Animal Hospital, Department of Veterinary Clinical Science, University of Liverpool, UK
    J Vet Intern Med 21:54-60. 2007
  6. ncbi Angiotensin I converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digestion of soy protein
    Wendy M Y Lo
    The University of British Columbia, Faculty of Agricultural Sciences, Food Science Building, 6650 N W Marine Drive, Vancouver, British Columbia V6T 1Z4, Canada
    J Agric Food Chem 53:3369-76. 2005
  7. ncbi High-gradient magnetic affinity separation of trypsin from porcine pancreatin
    Jürgen J Hubbuch
    Center for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800, Kgs Lyngby, Denmark
    Biotechnol Bioeng 79:301-13. 2002
  8. ncbi Preparation and in vivo efficacy study of pancreatin microparticles as an enzyme replacement therapy for pancreatitis
    Sonali Raosaheb Naikwade
    C U Shah College of Pharmacy, S N D T Women s University, Santacruz W, Mumbai, Maharashtra, India
    Drug Dev Ind Pharm 35:417-32. 2009
  9. ncbi Properties of different pancreatin preparations used in pancreatic exocrine insufficiency
    Johannes Matthias Löhr
    Gastrocentrum, Department of Surgical Gastroenterology, Karolinska Institute University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Eur J Gastroenterol Hepatol 21:1024-31. 2009
  10. ncbi Iron availability from iron-fortified spirulina by an in vitro digestion/Caco-2 cell culture model
    G Puyfoulhoux
    , , , Montpellier, France
    J Agric Food Chem 49:1625-9. 2001

Detail Information

Publications220 found, 100 shown here

  1. ncbi Mismatch of duodenal deliveries of dietary fat and pancreatin from enterically coated microspheres
    J H Meyer
    Department of Medicine, Sepulveda VA Medical Center, California, USA
    Pancreas 15:226-35. 1997
    ..We speculated that the similar transits of the 1.2-mm Creon and the 2-mm Pancrease resulted from aggregation of these microspheres in the presence of free oil...
  2. ncbi Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
    ..This investigation was designed to evaluate the impact of enzyme-replacement therapy on glucose metabolism and diabetes treatment in a prospective study of insulin-treated patients with diabetes mellitus...
  3. ncbi A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency
    U Halm
    Department of Internal Medicine II, University of Leipzig, Germany
    Aliment Pharmacol Ther 13:951-7. 1999
    Modern pancreatin preparations consist of enteric-coated microspheres to protect the enzymes from gastric acid...
  4. ncbi A 2-year post-authorization safety study of high-strength pancreatic enzyme replacement therapy (pancreatin 40,000) in cystic fibrosis
    James M Littlewood
    UK Cystic Fibrosis Trust, 11 London Road, Bromley, Kent BR1 1BY, UK
    Expert Opin Drug Saf 10:197-203. 2011
    ....
  5. ncbi Prognostic factors in canine exocrine pancreatic insufficiency: prolonged survival is likely if clinical remission is achieved
    Daniel J Batchelor
    Small Animal Hospital, Department of Veterinary Clinical Science, University of Liverpool, UK
    J Vet Intern Med 21:54-60. 2007
    ..Response to therapy in canine exocrine pancreatic insufficiency (EPI) varies considerably, making it difficult to determine prognosis for individual patients...
  6. ncbi Angiotensin I converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digestion of soy protein
    Wendy M Y Lo
    The University of British Columbia, Faculty of Agricultural Sciences, Food Science Building, 6650 N W Marine Drive, Vancouver, British Columbia V6T 1Z4, Canada
    J Agric Food Chem 53:3369-76. 2005
    ..ACE) inhibitory activity was determined in the soy protein isolate (SPI) digest produced by in vitro pepsin-pancreatin sequential digestion...
  7. ncbi High-gradient magnetic affinity separation of trypsin from porcine pancreatin
    Jürgen J Hubbuch
    Center for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800, Kgs Lyngby, Denmark
    Biotechnol Bioeng 79:301-13. 2002
    ..In small-scale studies approximately 95% of the endogenous trypsin present in a crude porcine pancreatin feedstock was recovered with a purification factor of approximately 4...
  8. ncbi Preparation and in vivo efficacy study of pancreatin microparticles as an enzyme replacement therapy for pancreatitis
    Sonali Raosaheb Naikwade
    C U Shah College of Pharmacy, S N D T Women s University, Santacruz W, Mumbai, Maharashtra, India
    Drug Dev Ind Pharm 35:417-32. 2009
    ..b>Pancreatin microspheres were prepared by emulsification phase separation by nonsolvent addition and solvent evaporation ..
  9. ncbi Properties of different pancreatin preparations used in pancreatic exocrine insufficiency
    Johannes Matthias Löhr
    Gastrocentrum, Department of Surgical Gastroenterology, Karolinska Institute University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Eur J Gastroenterol Hepatol 21:1024-31. 2009
    ..Pancreatic enzyme preparations, generically called pancreatin, are not alike. Rather, they present a broad variety of pancreatin composition.
  10. ncbi Iron availability from iron-fortified spirulina by an in vitro digestion/Caco-2 cell culture model
    G Puyfoulhoux
    , , , Montpellier, France
    J Agric Food Chem 49:1625-9. 2001
    ..5-fold increase appeared using spirulina digest in comparison with meat. In view of this observed high iron availability from spirulina, we conclude that spirulina could represent an adequate source of iron...
  11. ncbi Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD
    W Seefelder
    Quality and Safety Assurance Department, Nestle Research Center, Nestec Ltd, CH 1000 Lausanne 26, Switzerland
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:391-400. 2008
    ..Further work on the bioavailability, metabolism and possible toxicity of chloroesters per se is warranted...
  12. ncbi Fate of swallowed interleukin 8 and TNF alpha, and effect on the Wistar rat gut
    G L Briars
    Department of Gastroenterology and Nutrition, Royal Children s Hospital Brisbane, Herston, Queensland 4029, Australia
    J Cyst Fibros 1:94-8. 2002
    ..We serially immuno-assayed IL-8 and TNF alpha solutions co-incubated with each of three pancreatin preparations at pH 4.5 and pH 8...
  13. ncbi In vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin C
    Antonio Pérez-Vicente
    Laboratorio Fitoquímica, Departamento Ciencia y Tecnología de los Alimentos, CEBAS CSIC, Apartado 4195, 30080 Murcia, Spain
    J Agric Food Chem 50:2308-12. 2002
    ..Nevertheless, due to pH, anthocyanins are largely transformed into non-red forms and/or degraded (97%), and similar results are obtained for vitamin C (>95% degradation)...
  14. ncbi In vitro study on digestion of peptides in Emmental cheese: analytical evaluation and influence on angiotensin I converting enzyme inhibitory peptides
    Sandrine Parrot
    Laboratoire de Recherche en Génie Industriel Alimentaire, Rue Henri de Boissieu, F 01060 Bourg en Bresse, France
    Nahrung 47:87-94. 2003
    ..This protocol consisted in a 30 min incubation with pepsin followed by a 4 h incubation with trypsin or pancreatin. It was applied to an Emmental cheese water-soluble extract (WSE) and to a casein solution (as a control)...
  15. ncbi Antihypertensive properties of spinach leaf protein digests
    Yanjun Yang
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Agric Food Chem 52:2223-5. 2004
    ..Pepsin and pepsin-pancreatin digests of spinach leaf protein have potent angiotensin-I converting enzyme inhibitory properties with IC(50) ..
  16. ncbi Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale
    Noriko Higaki-Sato
    Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo, Japan
    J Agric Food Chem 51:8-13. 2003
    An enzymatic hydrolysate of wheat gluten was further digested in vitro with porcine pepsin and pancreatin to obtain an indigestible peptide...
  17. ncbi Chitosan-alginate multilayer beads for gastric passage and controlled intestinal release of protein
    Anil K Anal
    Bioprocess Technology Program, Asian Institute of Technology, Klong Luang, Bangkok, Thailand
    Drug Dev Ind Pharm 29:713-24. 2003
    ..The multilayer beads disintegrated very slowly. The enzymes pepsin and pancreatin did not change the characteristics of BSA-loaded chitosan-alginate beads...
  18. ncbi Stability of recombinant human alpha-1-antitrypsin produced in rice in infant formula
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis 95616, USA
    J Nutr Biochem 14:386-93. 2003
    ..This study shows that recombinant AAT may survive the conditions of the infant stomach and duodenum and affect protein digestion in the infant small intestine...
  19. ncbi Spasmocanulase in irritable bowel syndrome
    Abdelrahman E Mohamed
    Department of Gastroenterology, Armed Forces Hospital, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia
    Saudi Med J 23:1074-7. 2002
    ..Spasmocanulase, which has an anti-spasmodic and anti-flatulence effect and contains several ingredients, was tried in patients with irritable bowel syndrome, who had been on other medications previously without improvement...
  20. ncbi Estimation of arsenic bioaccessibility in edible seaweed by an in vitro digestion method
    J M Laparra
    Institute of Agrochemistry and Food Technology CSIC, Aptdo 73, 46100, Burjassot Valencia, Spain
    J Agric Food Chem 51:6080-5. 2003
    ..An in vitro gastrointestinal digestion (pepsin, pH 2, and pancreatin-bile extract, pH 7) was applied to obtain the mineral soluble fraction of three seaweeds (Hizikia fusiforme, ..
  21. ncbi Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability
    Winyoo Chowanadisai
    Department of Nutrition, The University of California, Davis 95616, USA
    Am J Clin Nutr 76:828-33. 2002
    ..It has been hypothesized that alpha(1)-antitrypsin and antichymotrypsin may modulate digestion in the infant gut...
  22. ncbi In vitro gastrointestinal digestion study of broccoli inflorescence phenolic compounds, glucosinolates, and vitamin C
    Fernando Vallejo
    Departamento de Ciencia y Tecnologia de los Alimentos, CEBAS CSIC, PO Box 164, 30100 Espinardo, Murcia, Spain
    J Agric Food Chem 52:135-8. 2004
    ..Thus, glucosinolates were mainly degraded by gastric conditions, whereas phenolic compounds and vitamin C were degraded by intestinal conditions...
  23. ncbi The effect of pH, time and dietary source of cadmium on the bioaccessibility and adsorption of cadmium to/from lettuce (Lactuca sativa L. cv. Ostinata)
    M Waisberg
    Department of Land Resource Science, University of Guelph, Guelph, Ontario, Canada
    Food Chem Toxicol 42:835-42. 2004
    ..Therefore we suggest that part of the reduction in bioaccessibility following intestinal digestion could be explained by an increase in adsorption of metal to the plant material at higher pH values...
  24. ncbi Interactions of different phenolic acids and flavonoids with soy proteins
    Harshadrai M Rawel
    Institute of Nutritional Science, University of Potsdam, A Scheunert Allee 114 116, D 14558 Bergholz Rehbruecke, Germany
    Int J Biol Macromol 30:137-50. 2002
    ..The influence of derivatization on the in-vitro digestibility with trypsin, chymotrypsin, pepsin and pancreatin was also assessed...
  25. ncbi Purification of an ACE inhibitory peptide after hydrolysis of sunflower (Helianthus annuus L.) protein isolates
    Cristina Megías
    Instituto de la Grasa, Padre Garcia Tejero 4, 41012 Sevilla, Spain
    J Agric Food Chem 52:1928-32. 2004
    Sunflower protein isolates and the proteases pepsin and pancreatin were used for the production of protein hydrolysates that inhibit angiotensin-I converting enzyme (ACE)...
  26. ncbi Chitosan/beta-lactoglobulin core-shell nanoparticles as nutraceutical carriers
    Lingyun Chen
    Chaire de recherche du Canada sur les proteines, Institut de recherche sur les nutraceutiques et les aliments fonctionnels INAF STELA, Universite Laval, Pavillon Paul Comtois, Sainte Foy, Que, Canada
    Biomaterials 26:6041-53. 2005
    ..When transferred to simulated intestinal conditions, the (beta)lg shells of the nanoparticles were degraded by pancreatin.
  27. ncbi Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco
    Yanjun Yang
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Agric Food Chem 51:4897-902. 2003
    ..angiotensin I-converting enzyme (ACE), that is, MRWRD, MRW, LRIPVA, and IAYKPAG, were isolated from the pepsin-pancreatin digest of spinach Rubisco with the use of HPLC. IC(50) values of individual peptides were 2.1, 0.6, 0.38, and 4...
  28. ncbi Phenanthrene release from natural organic matter surrogates under simulated human gastrointestinal conditions
    Christopher M Hurdzan
    Soil Science Program, Ohio State University, Columbus, OH 43210, USA
    Ecotoxicol Environ Saf 69:525-30. 2008
    ..These data demonstrate that the fractions of NOM retained phenanthrene to a varying extent and thus the predictions of phenanthrene bioavailability should also be assessed on the basis of the constituents of the NOM matrix...
  29. ncbi Effects of block length on the enzymatic degradation and erosion of oxazoline linked poly-epsilon-caprolactone
    Mika Pulkkinen
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Eur J Pharm Sci 31:119-28. 2007
    ..Solvent cast PCL and PCL-O films were incubated (22 days) in the presence of pancreatin (1%, pH 7.5), with and without enzyme inhibitors...
  30. ncbi Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, 2100, Copenhagen, Denmark
    Pharm Res 24:1844-53. 2007
    ..To investigate the structural development of the colloid phases generated during lipolysis of a lipid-based formulation in an in vitro lipolysis model, which simulates digestion in the small intestine...
  31. ncbi A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats
    Ben J Boyd
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia
    Int J Pharm 340:52-60. 2007
    ..The results indicate that lipids that form liquid crystalline structures in excess water, may have application as an oral sustained release delivery system, providing they are not digested rapidly on administration...
  32. ncbi Ruminal and intestinal degradability of distillers grains plus solubles varies by source
    D H Kleinschmit
    Dairy Science Department, South Dakota State University, Brookings 57007, USA
    J Dairy Sci 90:2909-18. 2007
    ..Feeds were incubated in the rumen for 3, 6, 12, 18, 24, and 36 h. Intestinal CP digestibility via pepsin and pancreatin and AA profiles were measured on residue from 12-h ruminal incubation of feeds...
  33. ncbi Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb)
    Jin Boo Jeong
    School of Bioresources Sciences, Andong National University, Korea
    J Agric Food Chem 55:10707-13. 2007
    ..assay for measuring bioavailability was carried out on SNL crude protein and autoclaved SNL using pepsin and pancreatin. A nonradioactive histone acetyltransferase (HAT) assay and HAT activity colorimetric assay were used to measure ..
  34. ncbi Pancreatic enzyme pharmacotherapy
    Marcus Ferrone
    Department of Clinical Pharmacy, Drug Product Services Laboratory, University of California, San Francisco, California 94118 0613, USA
    Pharmacotherapy 27:910-20. 2007
    ..Despite the large number of specialty enzyme replacements available commercially, many patients remain dissatisfied with standard therapy, and future developments are needed to optimize treatment in these individuals...
  35. ncbi In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium
    L Masco
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Dairy Sci 90:3572-8. 2007
    ..the bifidobacterial strains used in this study appeared to possess a natural ability to survive the presence of pancreatin (pH 8.0)...
  36. ncbi Improvement of digestibility, reduction in allergenicity, and induction of oral tolerance of wheat gliadin by deamidation
    Hitomi Kumagai
    Department of Agricultural and Biological Chemistry, Nihon University, Fujisawa shi, Japan
    Biosci Biotechnol Biochem 71:977-85. 2007
    ..Deamidation of gliadin reduced its reactivity toward the sera of patients with wheat allergy. Rats administered with deamidated gliadin showed suppressed elevation of the gliadin-specific IgE level...
  37. ncbi Investigations into inhibitor type and mode, simulated gastrointestinal digestion, and cell transport of the angiotensin I-converting enzyme-inhibitory peptides in Pacific hake (Merluccius productus) fillet hydrolysate
    Crystal D Cinq-Mars
    Food, Nutrition, and Health Program, Faculty of Land and Food Systems, 2205 East Mall, The University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4
    J Agric Food Chem 56:410-9. 2008
    ..Pacific hake fillet hydrolysates are a potentially bioavailable source of ACE-inhibitory peptides awaiting further in vivo study...
  38. ncbi Production of rice protein by alkaline extraction improves its digestibility
    Takehisa Kumagai
    Kameda Seika Co, Ltd, Niigata 950 0192, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:467-72. 2006
    ..In an in vitro digestion study with pepsin and pancreatin, both the SDS-PAGE analysis of protein pattern and the crude protein content of undigested residue clearly ..
  39. ncbi An assessment of the bioavailability of persistent organic pollutants from contaminated soil
    W C Scott
    School of Applied Sciences, Northumbria University, Ellison Building, Newcastle upon Tyne, UKNE1 8ST
    J Environ Monit 7:710-5. 2005
    ..4 to 4.0% while following intestinal extraction ranged from 6.6 to 12.7%. It has been found that the majority of POPs present i.e. >75%, would be excreted if consumed and not be absorbed in the gastrointestinal tract of humans...
  40. ncbi Stability of anthocyanins from commercial black currant juice under simulated gastrointestinal digestion
    Alija Uzunović
    Institute for Quality Control of Medicines, Titova 9, 71 000 Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 8:254-8. 2008
    ..during in vitro digestion in gastric and intestinal fluid regarding whether appropriate enzyme (pepsin or pancreatin) was added or not...
  41. ncbi Structural and functional properties of amylose complexes with genistein
    Revital Cohen
    Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel
    J Agric Food Chem 56:4212-8. 2008
    ..showed high retention of genistein in simulated stomach conditions and released genistein upon digestion in pancreatin solution. It is therefore suggested that the complexes can be used as carriers for the slow release of genistein.
  42. ncbi Zein microspheres as drug/antigen carriers: a study of their degradation and erosion, in the presence and absence of enzymes
    Pepi Hurtado-López
    Department of Pharmaceutics, School of Pharmacy, University of London, London, UK
    J Microencapsul 23:303-14. 2006
    ..in the absence of enzymes (which explains the slow release of entrapped solute), but were degraded by pepsin and pancreatin enzymes in simulated gastric and intestinal fluids, respectively (which indicates that release is likely to be ..
  43. ncbi Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion
    Andrew P Neilson
    Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907, USA
    J Agric Food Chem 55:8941-9. 2007
    ..These data provide a logical basis for initial screening to detect catechin digestive products in vivo...
  44. ncbi Probiotic preparation has the capacity to hydrolyze proteins responsible for wheat allergy
    Maria de Angelis
    Department of Plant Protection and Applied Microbiology, University of Bari, 70126 Bari, Italy
    J Food Prot 70:135-44. 2007
    ..allergic patients, several IgE-binding proteins persisted after treatment of baker's yeast bread by pepsin and pancreatin. The signal of all these IgE-binding proteins disappeared after further treatment by VSL#3...
  45. ncbi Validation and application of a stability-indicating HPLC method for the in vitro determination of gastric and intestinal stability of venlafaxine
    Ebenezer B Asafu-Adjaye
    Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States
    J Pharm Biomed Anal 43:1854-9. 2007
    ..This stability experiment in simulated gastric and intestinal fluids suggests that drug loss in the gastrointestinal tract takes place by membrane permeation rather than a degradation process...
  46. ncbi [Does enzyme substitution therapy reduce pain in chronic pancreatitis?]
    Marie Louise Hvass Hansen
    Amtssygehuset i Gentofte, Medicinsk afdeling F
    Ugeskr Laeger 167:1841-4. 2005
  47. ncbi Pancreatic enzyme extract improves survival in murine pancreatic cancer
    Murat Saruc
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Pancreas 28:401-12. 2004
    ..Based on a recent report on the effectiveness of pancreatic enzyme therapy, we examined the effect of porcine pancreatic enzyme extracts (PPE) on human PC xenografts in nude mice...
  48. ncbi A dynamic in vitro lipolysis model. II: Evaluation of the model
    N H Zangenberg
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
    Eur J Pharm Sci 14:237-44. 2001
    ..This difference between danazol and probucol was attributed to the effect of different lipophilicity...
  49. ncbi Weaning and feed intake alter pancreatic enzyme activities and corresponding mRNA levels in 7-d-old piglets
    Julia Marion
    Unité Mixte de Recherches sur le Veau et le Porc, Institut National de la Recherche Agronomique, St Gilles, France
    J Nutr 133:362-8. 2003
    ..Therefore, the pancreas can adjust to weaning and dry food intake as early as wk 2 of life...
  50. ncbi Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: development, characterization and interaction with leuprolide
    M Carafa
    Dept Scienze del Farmaco, University G D Annunzio, Via dei Vestini, 66100 Chieti, Italy
    Int J Pharm 325:155-62. 2006
    ..bilayer fluidity, stability in serum, in simulated gastric and intestinal fluids and against sodium cholate and pancreatin. Leuprolide, a synthetic superpotent agonist of luteinizing hormone releasing hormone (LHRH) receptor, was ..
  51. ncbi Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols
    Janne Ørskov Christensen
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Eur J Pharm Sci 23:287-96. 2004
    ..Differences in the physicochemical properties of the drugs resulted in differences in their distribution between the phases arising during lipolysis...
  52. ncbi Improving digestibility of soy flour by reducing disulfide bonds with thioredoxin
    Richard J Faris
    Department of Animal Science, Iowa State University, 1221 Kildee Hall, Ames, Iowa 50011, USA
    J Agric Food Chem 56:7146-50. 2008
    ..system (NTS) effectively reduced disulfide bonds in soy flour and increased protein digestibility by trypsin and pancreatin as measured by the pH stat method...
  53. ncbi [Effect of endogenous enzymes on composition of oligonucleotides isolated from gonads of hydrobionts]
    Iu M Pozdniakova
    Pacific Research Fisheries Center TINRO Center, Vladivostok, 690950, Russia
    Prikl Biokhim Mikrobiol 39:524-9. 2003
    ..It was demonstrated that high activities of endogenous enzymes (nucleases and proteases) in milts of hydrobionts correlated with the degree of hydrolysis of their nucleic acids...
  54. ncbi Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract
    W P Charteris
    SET Consultants Ltd, Douglas, Cork, Ireland
    J Appl Microbiol 84:759-68. 1998
    ..3% w/v) and sodium chloride (0.5% w/v), and a simulated small intestinal juice (pH 8.0), containing pancreatin USP (1 g l-1) and sodium chloride (5 g l-1), and monitoring changes in total viable count periodically...
  55. ncbi Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period cros
    Gavin R Graff
    Penn State Milton S Hershey Medical Center, Penn State Medical School, Department of Pediatrics, Hershey, Pennsylvania 17033 0850, USA
    Clin Ther 32:89-103. 2010
    ..The US Food and Drug Administration regulations now require all PERT products to undergo clinical efficacy and safety studies before they can be considered for marketing approval...
  56. ncbi The in vitro hydrolysis of phytosterol conjugates in food matrices by mammalian digestive enzymes
    Robert A Moreau
    Crop Conversion Science and Engineering Research Unit, ERRC, ARS, USDA, Wyndmoor, Pennsylvania 19038, USA
    Lipids 39:769-76. 2004
    ..of hydrolysis of four common phytosterol conjugates by mammalian digestive enzymes (cholesterol esterase and pancreatin, a mixture of pancreatic enzymes) and for comparison purposes, by KOH...
  57. ncbi T cells expressing the gamma delta T cell receptor induce apoptosis in cardiac myocytes
    S A Huber
    Department of Pathology, University of Vermont, Colchester 05446, USA
    Cardiovasc Res 45:579-87. 2000
    ..The objective of the present studies is to demonstrate that gamma delta T cells directly induce greater Fas-dependent apoptosis of cultured myocytes than T cells expressing the alpha beta TcR...
  58. ncbi Comparative studies on the in vitro properties of phytases from various microbial origins
    F A Igbasan
    Freie Universitat Berlin, Institut für Tierernährung, Fachbereich Veterinarmedizin, Brümmer Strasse 34, D 14195 Berlin, Germany
    Arch Tierernahr 53:353-73. 2000
    ..coli phytase was insensitive against pepsin and pancreatin. Incubation of the enzymes in digesta supernatants from various segments of the digestive tract of hens revealed ..
  59. ncbi Biodegradable microspheres based on gelatin-porcine mucin admixtures: in vitro and in vivo delivery studies
    Kenneth Chibuzor Ofokansi
    Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    Biol Pharm Bull 32:1754-9. 2009
    ..were evaluated for the in vitro delivery of cefaclor in both simulated intestinal fluid (SIF) without pancreatin (pH 7.4) and simulated gastric fluid (SGF) without pepsin (pH 1.2)...
  60. pmc Evaluation of the passage of Lactobacillus gasseri K7 and bifidobacteria from the stomach to intestines using a single reactor model
    Philipp Ritter
    Agroscope Liebefeld Posieux Research Station ALP, Schwarzenburgstrasse 161, CH 3003 Bern Liebefeld, Switzerland
    BMC Microbiol 9:87. 2009
    ..The advantage of this automated one reactor system was the ability to test the influence of acid, bile salts and pancreatin.Lactobacillus gasseri K7 is a strain isolated from infant faeces with properties making the strain interesting ..
  61. ncbi Starch-based coatings for colon-specific delivery. Part II: physicochemical properties and in vitro drug release from high amylose maize starch films
    C Freire
    Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, Sunderland, UK
    Eur J Pharm Biopharm 72:587-94. 2009
    ..2. Selected formulations were further assessed in simulated gastric and intestinal fluids containing pepsin and pancreatin, respectively. The free films prepared were smooth and homogeneous in their appearance...
  62. ncbi Inhibition of transforming growth factor beta (TGFbeta1) expression and extracellular matrix secretion in human peritoneal mesothelial cells by pcDU6 vector-mediated TGFbeta1 shRNA and by pcDNA3.1(-)-mediated antisense TGFbeta1 RNA
    Fuyou Liu
    Division of Nephrology, Nephrology Institute of Central South University, The Second Xiangya Hospital, Central South University, Changsha, China
    Adv Perit Dial 21:41-52. 2005
    ..human TGFbeta1 antisense mammalian expression vector, and we isolated HPMCs from human greater omentum by pancreatin disaggregation to establish a stable cell-culture model...
  63. ncbi [Repair of facial nerve with bioactive artificial nerve conduit: experiment with rats]
    Huai Dong Du
    Ear Nose Throat Department, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai 200031, China
    Zhonghua Yi Xue Za Zhi 87:3302-6. 2007
    ..To evaluate the effect of bioactive artificial nerve conduits in the repair of facial nerve defects...
  64. ncbi A reliable method to determine methylmercury and ethylmercury simultaneously in foods by gas chromatography with inductively coupled plasma mass spectrometry after enzymatic and acid digestion
    Stephen Wai Cheung Chung
    Food Research Laboratory, Centre for Food Safety, Food and Environmental Hygiene Department, 382 Nam Cheong Street, Hong Kong, China
    J Chromatogr A 1218:1260-5. 2011
    ..Samples were digested with pancreatin and then hydrochloric acid...
  65. ncbi Probiotic properties of yeasts isolated from chicken feces and kefirs
    Katarzyna Rajkowska
    Technical University of Łódź, Institute of Fermentation Technology and Microbiology, Łódź, Poland
    Pol J Microbiol 59:257-63. 2010
    ..3-93.7% after 4 hours of incubation in media with addition of 3 g/l pepsin and 1 g/l pancreatin. Kefir isolates were more sensitive to these conditions and a further 10% reduction of cell number in relation ..
  66. ncbi Pancreatic enzyme replacement therapy in post-pancreatectomy patients
    M Braga
    Department of Surgery, Scientific Institute H S Raffaele, Milano, Italy
    Int J Pancreatol 5:37-44. 1989
    ..Upon discharge from the hospital, patients received pancreatin powder as a dietary enzyme supplement (18,000 lipase U/meal)...
  67. pmc Prediction of adsorption from multicomponent solutions by activated carbon using single-solute parameters
    D E Wurster
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    AAPS PharmSciTech 1:E25. 2000
    ..of 3 barbiturates--phenobarbital, mephobarbital, and primidone--from simulated intestinal fluid (SIF), without pancreatin, by activated carbon was studied using the rotating bottle method...
  68. ncbi Ileal digestibility of amino acids, phosphorus, phytate and energy in pigs fed sorghum-based diets supplemented with phytase and Pancreatin®
    M Cervantes
    Instituto de Ciencias Agricolas, Universidad Autonoma de Baja California, Mexicali, Mexico
    J Anim Physiol Anim Nutr (Berl) 95:179-86. 2011
    ..Two experiments evaluated the effect of providing a mixture of pancreatic enzymes (Pancreatin(®) ) to growing pigs fed sorghum-soybean meal diets supplemented with phytase on the AID of AA, energy, and ..
  69. ncbi Arsenic bioaccessibility and speciation in clams and seaweed from a contaminated marine environment
    I Koch
    Environmental Sciences Group, Royal Military College of Canada, PO Box 17000 Station Forces, Kingston, ON, Canada K7K 7B4
    Mar Pollut Bull 54:586-94. 2007
    ..5 and glycine for 1h followed by pancreatin, bile extract and pH adjustment to 7 for an additional 4h) and speciation of arsenic in extracts (HPLC-HG-AAS to ..
  70. ncbi Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry
    Muriel Lalanne
    Universite Paris Sud, CNRS, UMR 8612, IFR 141, 5, rue J B Clement, F 92296 Chatenay Malabry, France
    Int J Pharm 379:235-43. 2009
    ..First, liposomal formulation of each prodrug was incubated with a lipolysis model based on pancreatin and analysed using liquid chromatography combined with tandem mass spectrometry (LC-MS/MS)...
  71. ncbi Cross-linking of hard gelatin carbamazepine capsules: effect of dissolution conditions on in vitro drug release
    Hervé Marchais
    Laboratoire de Pharmacie Galenique et Biopharmacie, ADEN UPRES EA 3234, UFR de Médecine Pharmacie, 22 Boulevard Gambetta, 76183 Rouen, France
    Eur J Pharm Sci 19:129-32. 2003
    ..SLS) was added in the dissolution medium at a concentration of 2% m/v both in SGF and SIF with pepsin and pancreatin, respectively. The percentage of CBZ dissolved was reduced by increasing the degree of gelatin cross-linking...
  72. ncbi Reducing, radical scavenging, and chelation properties of in vitro digests of alcalase-treated zein hydrolysate
    Lijuan Zhu
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
    J Agric Food Chem 56:2714-21. 2008
    ..5-2 h of pancreatin, 37 degrees C) in vitro digestion...
  73. ncbi [Pancreatic extract therapy in exocrine pancreatic insufficiency]
    B Santini
    Istituto di Discipline Pediatriche, Universita degli Studi di Torino, Cattedra di Pediatria
    Minerva Gastroenterol Dietol 39:133-7. 1993
    ..The authors consider all the different enzyme preparations from pancreatin powder to the 1st...
  74. ncbi Enzymatic recovery and purification of polyhydroxybutyrate produced by Ralstonia eutropha
    Fernanda M Kapritchkoff
    Agrupamento de Biotecnologia DQ, Instituto de Pesquisas Tecnológicas do Estado de São Paulo IPT, Cidade Universitaria, Av Prof Almeida Prado 532, CEP 05508 901 São Paulo, SP, Brazil
    J Biotechnol 122:453-62. 2006
    ..Aiming at improving the process efficiency and reducing the enzyme cost, experiments were carried out with pancreatin, leading to 90.0% polymer purity and an enzyme cost three times lower than the one obtained with bromelain...
  75. ncbi Postprandial carbohydrate metabolism in healthy subjects and those with type 2 diabetes fed starches with slow and rapid hydrolysis rates determined in vitro
    Chris J Seal
    Human Nutrition Research Centre, School of Agriculture, Food and Rural Development, Faculty of Science, Agriculture and Engineering, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK
    Br J Nutr 90:853-64. 2003
    ..the present study was to investigate the effects of starches with differing rates of hydrolysis on exposure to pancreatin in vitro on postprandial carbohydrate metabolism in healthy subjects and in subjects with type 2 diabetes...
  76. ncbi Bowman-Birk inhibitor and genistein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced macrophages
    Vermont P Dia
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 228 ERML, MC 051, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    J Agric Food Chem 56:11707-17. 2008
    ..A), saponin B group glycosides (saponin B), sapogenol B, Bowman-Birk inhibitor (BBI), lunasin, and pepsin-pancreatin glycinin hydrolysates were tested by measuring their ability to inhibit cyclooxygenase-2/prostaglandin E(2) (PGE(..
  77. ncbi Refining in vitro digestibility assays: fractionation of digestible and indigestible peptides
    Y Qiao
    Department of Animal Science, North Carolina State University, Raleigh 27695, USA
    J Anim Sci 82:1669-77. 2004
    ..A method that exhaustively digests proteins using pepsin and pancreatin was developed, and the first objective of this research was to confirm that exhaustive digestion was indeed ..
  78. pmc Neutralization assay for human group C rotaviruses using a reverse passive hemagglutination test for endpoint determination
    R Fujii
    Department of Microbiology, Okayama Prefectural Institute for Environmental Science and Public Health, Okayama 701 0212, Okayama 700 8558, Japan
    J Clin Microbiol 38:50-4. 2000
    ..Maintenance medium containing 100 microgram of pancreatin per ml was placed in each well...
  79. pmc Zymographic assay of plant diamine oxidase on entrapped peroxidase polyacrylamide gel electrophoresis. A study of stability to proteolysis
    Carmen Calinescu
    Department of Chemistry and Centre BioMed, Universite du Quebec a Montreal, CP 8888, Succ A, Montreal, QC, H3C 3P8, Canada
    Anal Bioanal Chem 396:1281-90. 2010
    ..the DAO content from the vegetal extract was kept almost constant in the simulated intestinal fluid (containing pancreatin or not), with a slight diminution in the presence of pancreatic proteases...
  80. ncbi Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a "cause and effect" theory of bifunctionality
    Gediminas A Biziulevicius
    Immunomodulators Research Sector, Institute of Immunology, Vilnius University, 29 Moletu plentas, LT 08409 Vilnius, Lithuania
    FEMS Immunol Med Microbiol 46:131-8. 2006
    ..and serum albumin) hydrolyzed with four gastrointestinal proteinases (trypsin, alpha-chymotrypsin, pepsin and pancreatin)] were examined...
  81. ncbi Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol
    Kevin M Turner
    Industrial Biochemistry Program, Department of Chemical and Environmental Sciences, University of Limerick, Limerick, Ireland
    Biotechnol Lett 33:617-21. 2011
    ..Conjugation also provided significant protection against the proteolytic component of pancreatin. Overall, the PEGylated enzyme retained over twice the levels of residual activity recorded for non-PEGylated ..
  82. ncbi In vitro digestibility techniques to predict apparent total tract energy digestibility of wheat in grower pigs
    P R Regmi
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    J Anim Sci 87:3620-9. 2009
    ..5 mL) for 6 h, pancreatin (150 mg/54.5 mL) for 18 h, and cellulase (75 mg/55.5 mL) for 24 h. In IVD-VIS, 0...
  83. ncbi Changes in the antioxidative property of herring (Clupea harengus) press juice during a simulated gastrointestinal digestion
    Thippeswamy Sannaveerappa
    Department of Chemical and Biological Engineering, Food Science, Chalmers University of Technology, Goteborg, Sweden
    J Agric Food Chem 55:10977-85. 2007
    ..and light muscle (LMPJ) was mixed with pepsin solution followed by stepwise pH adjustments and additions of pancreatin and bile solutions. Digestive enzymes were removed from samples by ultrafiltration (10 kDa)...
  84. ncbi [The progesterone-induced expression of cyclin G1 and its effect on the proliferation of mouse uterine epithelial cells]
    Yan Yan Ma
    Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sheng Li Xue Bao 60:541-6. 2008
    ..Then the uteri were digested by dispase and pancreatin respectively...
  85. ncbi Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion
    J M Laparra
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Burjassot Valencia, Spain
    J Cell Biochem 109:801-7. 2010
    ..alpha, beta, gamma, [symbol: see text] ) was subjected to in vitro gastrointestinal digestion (pepsin at pH 3, pancreatin-bile at pH 6), inoculated or not with cell suspensions (10(8) colony forming units/ml) of either B...
  86. ncbi New modalities in the treatment of exocrine pancreatic insufficiency in cystic fibrosis
    H G Heijerman
    Leyenburg Hospital, Department of Pulmonology, The Hague, Netherlands
    Neth J Med 41:105-9. 1992
    ..potency and duration of action compared to H2-antagonists, improves the efficacy of enteric-coated capsules of pancreatin dramatically...
  87. ncbi Iron uptake by Caco-2 cells following in vitro digestion: effects of heat treatments of pork meat and pH of the digests
    Anne D Sørensen
    Department of Human Nutrition Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, Denmark
    J Trace Elem Med Biol 24:230-5. 2010
    The present in vitro studies report on iron uptake by Caco-2 cells from pepsin and pepsin+pancreatin-digested pork meat proteins at pH values between 4.6 and 7 mimicking conditions in the duodenum and the proximal jejunum, respectively...
  88. ncbi Ruminal degradation and intestinal digestibility of dried or wet distillers grains with increasing concentrations of condensed distillers solubles
    Z J Cao
    Dairy Science Department, South Dakota State University, Brookings, SD 57007, USA
    J Anim Sci 87:3013-9. 2009
    ..Intestinal CP digestibility was measured on residue from 12-h ruminal incubation feeds by the pepsin-pancreatin method. The soluble fraction of DM and CP was greater (P < 0...
  89. ncbi Voluntary intake, chemical composition and in vitro digestibility of fresh forages fed to guinea pigs in periurban rearing systems of Kinshasa (Democratic Republic of Congo)
    J Bindelle
    Department of Animal Husbandry, Gembloux Agricultural University, 2 Passage des Deportes, 5030 Gembloux, Belgium
    Trop Anim Health Prod 39:419-26. 2007
    ..combination for GP diet, DVI was compared to their nutritional value measured in vitro using (1) a pepsin-pancreatin hydrolysis, (2) an gas fermentation test on the hydrolysed residues with an inoculum prepared from GP faeces, ..
  90. ncbi A method for the dispersal and characterization of leukocytes from the human female reproductive tract
    H D White
    Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Am J Reprod Immunol 44:96-103. 2000
    ..Here, we describe the isolation of RT cells in high yields and with high viability from the Fallopian tube, uterine endometrium, endocervix, ectocervix and vagina...
  91. ncbi Ionotropic cross-linked chitosan microspheres for controlled release of ampicillin
    Anil K Anal
    Riddet Centre, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Int J Pharm 312:166-73. 2006
    ..2) and simulated intestinal fluid (SIF, pH 7.5). The inclusion of the enzymes pepsin and pancreatin did not affect the stability of the microspheres...
  92. ncbi Stability of liposomes containing bio-enhancers and tetraether lipids in simulated gastro-intestinal fluids
    Johannes Parmentier
    Institute of Pharmacy and Molecular Biotechnology, Department of Pharmaceutical Technology and Biopharmacy, University of Heidelberg, Im Neuenheimer Feld 366, D 69120 Heidelberg, Germany
    Int J Pharm 405:210-7. 2011
    ..bio-enhancers cholylsarcosine, octadecanethiol and TPGS 1000 in Tris buffer pH 2, sodium taurocholate 10mM and pancreatin was compared...
  93. ncbi Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats
    Hui Zhao
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    Peptides 29:345-9. 2008
    Met-Arg-Trp (MRW) has been isolated as an inhibitor for angiotensin I-converting enzyme (ACE) from a pepsin-pancreatin digest of spinach ribulose bisphosphate carboxylase/oxygenase (Rubisco) (IC(50)=0.6 microM)...
  94. ncbi Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels
    Decheng Ma
    Merck Research Laboratories, Pharmaceutical Analysis and Control, P O Box 4, WP14 2E, West Point, PA 19486, USA
    J Pharm Biomed Anal 35:779-88. 2004
    ..After 24 h exposure in USP simulated fluids, the maximum amount of EHA extracted corresponds to < 0.3 microg of EHA per tablet. Pepsin and pancreatin in USP simulated fluids had no effect on EHA extraction and quantitation.
  95. ncbi Antioxidant and bile acid binding activity of buckwheat protein in vitro digests
    Yuanyuan Ma
    Department of Animal and Food Sciences, University of Kentucky, Lexington, Kentucky 40546, USA
    J Agric Food Chem 57:4372-80. 2009
    ..potential of buckwheat protein (BWP) during a two-stage in vitro digestion (1 h of pepsin followed by 2 h of pancreatin)...
  96. ncbi Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with "saccharides"
    Andrea Bernardos
    Instituto de Reconocimiento Molecular y Desarrollo Tecnológico IDM, Centro Mixto Universidad Politécnica de Valencia Universidad de Valencia, Spain
    ACS Nano 4:6353-68. 2010
    ..Delivery studies in pure water in the presence of pancreatin or β-d-galactosidase were carried out for S1-S3 and S4, respectively...
  97. ncbi A gene-shuffled glyphosate acetyltransferase protein from Bacillus licheniformis (GAT4601) shows no evidence of allergenicity or toxicity
    Bryan Delaney
    Pioneer Hi Bred International, Inc, Johnston, Iowa 50131, USA
    Toxicol Sci 102:425-32. 2008
    ..degraded in simulated gastric fluid containing pepsin (< 30 s) and in simulated intestinal fluid containing pancreatin (< 2 min) and completely inactivated at temperatures above 56 degrees C...
  98. ncbi Effects of phytases and dehulling treatments on in vitro iron and zinc bioavailability in faba bean (Vicia faba L.) flour and legume fractions
    Yuwei Luo
    College of Horticulture, Jinling Institute of Technology, 210038 Nanjing, P R China
    J Food Sci 75:C191-8. 2010
    ..Faba bean samples were sequentially digested with enzymes, including amylase, pepsin, pancreatin, and bile, under certain conditions following the enzymatic degradation procedure...
  99. ncbi Dietary glycosaminoglycans interfere in bacterial adhesion and gliadin-induced pro-inflammatory response in intestinal epithelial (Caco-2) cells
    J M Laparra
    Institute of Agrochemistry and Food Technology, Spanish National Research Council CSIC, PO Box 73, 46100 Burjassot, Valencia, Spain
    Int J Biol Macromol 47:458-64. 2010
    ..Gliadins were subjected to in vitro digestion (pepsin/pancreatin-bile), with/out GAGs, and the presence or not of cell suspensions of B. longum (10(8) CFU/ml). B. longum, E...
  100. ncbi Bioavailability of insect growth regulators in citrus and stone fruits
    P Paya
    Departamento Quimica Agricola, Geologia y Edafologia, Facultad de Quimica, Universidad de Murcia, Campus de Espinardo, S N, 30100, Espinardo, Murcia, Spain
    Commun Agric Appl Biol Sci 72:151-9. 2007
    ..The intestinal digestion was simulated with porcine pancreatin at pH 7, for 2 h in a shaking water bath at 37 degrees C...
  101. ncbi Nutritive value of unconventional fibrous ingredients fed to Guinea pigs in the Democratic Republic of Congo
    J Bindelle
    Gembloux Agricultural University, Animal Science Unit, 2 Passage des Deportes, 5030 Gembloux, Belgium
    Trop Anim Health Prod 41:1731-40. 2009
    ..The forages and the diets were digested in vitro using pepsin and pancreatin hydrolysis and gas fermentation test to simulate stomach, small intestine and large intestine, respectively...

Research Grants10

  1. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..or conditions mimicking the intestinal microenvironment include intestinal content filtrates, bile acids and pancreatin that enhance propagation of fastidious enteric viruses, including enteric caliciviruses...
  2. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
  3. Studying the interaction of Flor-Essence Tonic and PHIP
    Kristen Kulp; Fiscal Year: 2004
    ..It is important to determine how currently used CAMs are interacting with dietary carcinogens to influence health. Science based information is needed so that people can make informed lifestyle choices. ..
  4. Microvascular Injury and Pancreatic Enzyme Products
    GEERT SCHMID SCHOENBEIN; Fiscal Year: 2005
    ..Understanding the trigger mechanisms for inflammation in shock will lead to new treatment modalities in man. ..
  5. A Novel Iron-Binding Component of Breast Milk
    Robert Serfass; Fiscal Year: 2004
    ..The proposed studies are essential prerequisites to future studies concerning the purported effects of the low molecular weight substance(s) in breast milk on iron absorption in animal models and in infants. ..
  6. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  7. 2007 Molecular Mechansims in Lymphatic Function & Disease
    GEERT SCHMID SCHOENBEIN; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  8. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  9. 2006 Molecular Mechanisms in Lymphatic Function & Disease Gordon Conference
    GEERT SCHMID SCHOENBEIN; Fiscal Year: 2006
    ..The conference plays an essential role in the advancement of lymphology and development of a new understanding of lymphatic diseases and treatments. [unreadable] [unreadable] [unreadable] [unreadable]..