renin

Summary

Summary: An enzyme which is secreted by the KIDNEY and is formed from prorenin in plasma and kidney. The enzyme cleaves the Leu-Leu bond in ANGIOTENSINOGEN to generate ANGIOTENSIN I. This enzyme was formerly listed as EC 3.4.99.19.

Top Publications

  1. ncbi Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    J Clin Endocrinol Metab 85:1863-7. 2000
  2. doi Brain renin-angiotensin--a new look at an old system
    John W Wright
    Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
    Prog Neurobiol 95:49-67. 2011
  3. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
  4. doi The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
  5. doi Cardiorenal end points in a trial of aliskiren for type 2 diabetes
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 367:2204-13. 2012
  6. ncbi Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells
    William B Strawn
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Haematol 126:120-6. 2004
  7. pmc 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system
    Yan Chun Li
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 110:229-38. 2002
  8. ncbi Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
    Y Huang
    Fibrosis Research Laboratory, Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Kidney Int 69:105-13. 2006
  9. ncbi Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes
    Kenichi Matsushita
    Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Hypertension 48:1095-102. 2006
  10. pmc Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    Jennifer L Pluznick
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:4410-5. 2013

Detail Information

Publications362 found, 100 shown here

  1. ncbi Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    J Clin Endocrinol Metab 85:1863-7. 2000
    ..may be common in patients with essential hypertension (EH) when determinations of serum aldosterone (SA), plasma renin activity (PRA), and the SA/PRA ratio are used as screening...
  2. doi Brain renin-angiotensin--a new look at an old system
    John W Wright
    Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
    Prog Neurobiol 95:49-67. 2011
    The classic renin-angiotensin system (RAS) is described as a circulating hormone system focused on cardiovascular and body water regulation, with angiotensin II as its major effector...
  3. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the pathophysiology of hypertension and organ injury has changed to a major emphasis on the role of the local RAS in specific tissues...
  4. doi The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
    The (pro)renin receptor [(P)RR], encoded in ATP6AP2, plays a key role in the activation of local renin-angiotensin system (RAS). A truncated form of (P)RR, termed M8...
  5. doi Cardiorenal end points in a trial of aliskiren for type 2 diabetes
    Hans Henrik Parving
    Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 367:2204-13. 2012
    This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both.
  6. ncbi Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells
    William B Strawn
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Haematol 126:120-6. 2004
    The existence of a bone marrow renin-angiotensin system (RAS) is evidenced by the association of renin, angiotensin converting enzyme (ACE), and angiotensin (Ang) II and its AT(1) and AT(2) receptors with both normal and disturbed ..
  7. pmc 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system
    Yan Chun Li
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 110:229-38. 2002
    Inappropriate activation of the renin-angiotensin system, which plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major risk factor for hypertension, heart attack, and stroke...
  8. ncbi Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
    Y Huang
    Fibrosis Research Laboratory, Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Kidney Int 69:105-13. 2006
    Recent evidence suggesting a strong interplay between components of the renin-angiotensin system and key mediators of fibrosis led us to hypothesize that renin, independent of its enzymatic action to enhance angiotensin (Ang) II ..
  9. ncbi Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes
    Kenichi Matsushita
    Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Hypertension 48:1095-102. 2006
    Clinical and experimental evidence suggest that the renin-angiotensin system (RAS) plays a role in metabolic syndrome. Adipogenesis is suggested to modulate obesity and obesity-related consequences, such as metabolic syndrome...
  10. pmc Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    Jennifer L Pluznick
    Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:4410-5. 2013
    ..Olfr78 is expressed in the renal juxtaglomerular apparatus, where it mediates renin secretion in response to SCFAs...
  11. pmc Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition
    Chiao Yin Sun
    School of Medicine, Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 7:e34026. 2012
    ..The aim of this study was to define the putative pathological roles of the renal renin-angiotensin-aldosterone system (RAAS) and renal tubular epithelial-to-mesenchymal transition (EMT) in kidney ..
  12. doi Potassium homeostasis and renin-angiotensin-aldosterone system inhibitors
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Room N3W143, Baltimore, MD 21201, USA
    Clin J Am Soc Nephrol 5:531-48. 2010
    Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating hypertension and cardiovascular and renal diseases...
  13. ncbi Vitamin D regulation of the renin-angiotensin system
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 88:327-31. 2003
    The renin-angiotensin system (RAS) plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis...
  14. ncbi Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
    The renin-angiotensin system (RAS) participates in preeclampsia; however, the relative contributions from the circulating RAS and the tissue-based, uteroplacental RAS are unknown...
  15. pmc Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
    Minolfa C Prieto
    Department of Physiology and Hypertension and Renal Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Renal Physiol 300:F749-55. 2011
    ..Upregulation of collecting duct (CD) renin may lead to increased ANG II formation during ANG II-dependent hypertension, thus contributing to this imbalance...
  16. ncbi Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension
    Robert Fischer
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Hypertension 51:540-6. 2008
    We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition on electrophysiological remodeling in angiotensin II-induced cardiac injury...
  17. doi Prenatal exposure to lipopolysaccharide alters the intrarenal renin-angiotensin system and renal damage in offspring rats
    Xue Qin Hao
    Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing, China
    Hypertens Res 33:76-82. 2010
    ..This study explored alterations of the renin-angiotensin system (RAS) during the development of hypertension induced by prenatal exposure to lipopolysaccharide ..
  18. doi Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes
    Y F Dong
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    Diabetologia 53:180-91. 2010
    The effect of renin inhibition on type 2 diabetes is still unclear...
  19. ncbi Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells
    Y Huang
    Division of Nephrology, Fibrosis Research Laboratory, University of Utah, Salt Lake City, Utah 84108, USA
    Kidney Int 72:45-52. 2007
    Recent evidence indicates that renin itself might be profibrotic, independent of angiotensin II; however, the signaling system by which renin exerts a direct effect is not known...
  20. ncbi Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome
    Satish R Raj
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 111:1574-82. 2005
    ..We prospectively tested the hypothesis that patients with POTS are hypovolemic compared with healthy controls and explored the role of plasma renin activity and aldosterone in the regulation of plasma volume.
  21. doi Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOS
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Alfred Hospital, Melbourne VIC 3004, Australia
    Eur J Heart Fail 13:107-14. 2011
    The renin-angiotensin-aldosterone system (RAAS) represents a key therapeutic target in heart failure (HF) management...
  22. pmc An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension
    Florian Alonso
    Service of Internal Medicine, Laboratory of Experimental Medicine 19 135S, University Hospital, CHUV 1011 Lausanne, Switzerland
    Cardiovasc Res 87:166-76. 2010
    ..We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent hypertension.
  23. doi Renin, (pro)renin and receptor: an update
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM and Collège de France Early Development and Pathologies Center for Interdisciplinary Research in Biology and Experimental Medicine Unit, 11 place Marcelin Berthelot, 75005, Paris, France
    Clin Sci (Lond) 120:169-78. 2011
    PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/..
  24. ncbi The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio
    Susan J Hood
    Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, UK
    Circulation 116:268-75. 2007
    ..higher estimates encourage search for adrenal adenomas in patients with elevated ratios of plasma aldosterone to renin. However, it is more likely that patients with normal plasma K+ and aldosterone belong to the polygenic spectrum ..
  25. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ..in adipose tissue may be increased especially in obese hypertensive subjects, a contribution of the adipose-tissue renin-angiotensin system to the development of insulin resistance and hypertension is conceivable in humans, but not yet ..
  26. doi Brain renin angiotensin in disease
    M Ian Phillips
    Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA
    J Mol Med (Berl) 86:715-22. 2008
    A brain renin angiotensin system (RAS) and its role in cardiovascular control and fluid homeostasis was at first controversial. This was because a circulating kidney-derived renin angiotensin system was so similar and well established...
  27. ncbi Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Klybeckstrasse 220, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 308:698-705. 2003
    ..Inhibitors of the renin-angiotensin system (RAS) have proven to be successful treatments for hypertension...
  28. pmc Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive rats
    Rodney J Bolterman
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 46:943-7. 2005
    ..II plays an important role in elevating blood pressure of spontaneously hypertensive rats, despite normal plasma renin activity, and that converting enzyme inhibitors (captopril) can effectively normalize blood pressure in the ..
  29. doi Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema
    Harikrishna Makani
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA
    Am J Med 124:128-35. 2011
    Peripheral edema is a common adverse effect of calcium channel blockers. The addition of a renin-angiotensin system blocker, either an angiotensin-converting enzyme inhibitor or an ARB, has been shown to reduce peripheral edema in a dose-..
  30. ncbi The paradox of the low-renin state in diabetic nephropathy
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 10:2382-91. 1999
    Although diabetic nephropathy is often a low renin state, the renin system appears to be implicated in its pathogenesis...
  31. ncbi High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells
    D B Vidotti
    Renal Div, UNIFESP, Rua Botucatu, 740, 04023 900 São Paulo, Brazil
    Am J Physiol Renal Physiol 286:F1039-45. 2004
    Increased intrarenal renin-angiotensin system activity contributes to diabetic nephropathy. ANG II generation in mesangial cells (MC) is increased by high-glucose (HG) exposure...
  32. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..RAPS) refers to the pathogenic mechanisms whereby prorenin binding to its receptor dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling via the receptor...
  33. ncbi High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes
    Vivek P Singh
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 293:H939-48. 2007
    ..is that cardiac ANG II is synthesized in the extracellular space from components of the circulating and/or local renin-angiotensin system...
  34. doi Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
    David L Feldman
    Novartis Institutes for BioMedical Research, Bldg 437, Rm 3317, One Health Plaza, E Hanover, NJ 07936, USA
    Hypertension 52:130-6. 2008
    The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats...
  35. doi Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats
    Joep H M van Esch
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 28:2145-55. 2010
    The blood pressure-lowering effect of the renin inhibitor aliskiren equals that of angiotensin-converting enzyme (ACE) inhibitors and angiotensin (Ang) II type 1 (AT1) receptor blockers...
  36. ncbi Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia
    T Sugaya
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 270:18719-22. 1995
    Angiotensin (AT) II, the bioactive octapeptide in the renin-angiotensin system that plays a key role in cardiovascular homeostasis, exerts its multiple effects through the different types of AT receptors, AT1a, AT1b, and AT2...
  37. ncbi Continuous inhibition of the renin-angiotensin system and protection from hypertensive end-organ damage by brief treatment with angiotensin II type 1 receptor blocker in stroke-prone spontaneously hypertensive rats
    Kumiko Takemori
    Department of Pathology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Life Sci 77:2233-45. 2005
    ..Plasma renin activity (PRA), plasma angiotensin II (AII) levels and cerebral angiotensin-converting enzyme (ACE) activity were ..
  38. ncbi Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension
    Azra Mahmud
    Department of Therapeutics and Hypertension Clinic, St James s Hospital, Dublin, Ireland
    Am J Hypertens 18:50-5. 2005
    Some 10% to 15% of hypertensive patients have hyperaldosteronism, an increased ambulant aldosterone-to-renin ratio...
  39. ncbi Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes
    C Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Wynn Domain, Baker Heart Research Institute, Melbourne, Vic, Australia
    Int J Biochem Cell Biol 38:737-51. 2006
    Activation of the renin-angiotensin system has a pivotal role in the pathogenesis of diabetic complications. However, recent evidence suggests that it may also contribute to the development of diabetes itself...
  40. ncbi (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1139-46. 2007
    Blockade of (pro)renin receptor has benefits in diabetic angiotensin II type-1a-receptor-deficient mice, suggesting the importance of (pro)renin receptor-mediated intracellular signals...
  41. pmc Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats
    Alexis A Gonzalez
    Department of Physiology, Tulane University, School of Medicine, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Hypertension 57:859-64. 2011
    b>Renin synthesis and secretion by principal cells of the collecting duct are enhanced in angiotensin (Ang) II-dependent hypertension...
  42. pmc Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension
    Wencheng Li
    Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hypertension 59:1188-94. 2012
    The (pro)renin receptor is a newly discovered member of the brain renin-angiotensin system...
  43. doi A new look at the renin-angiotensin system--focusing on the vascular system
    Aurelie Nguyen Dinh Cat
    Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Peptides 32:2141-50. 2011
    The renin-angiotensin system (RAS), critically involved in the control of blood pressure and volume homeostasis, is a dual system comprising a circulating component and a local tissue component...
  44. pmc Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans
    Bindu Chamarthi
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 24:1143-8. 2011
    ..The aim of this study was to examine the relationship of IL-6 and renin-angiotensin system (RAS) activity in human hypertension.
  45. doi Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai 980 8578, Japan
    Peptides 30:2316-22. 2009
    Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, was associated with organ damage in the kidney. However, there has been little information for (P)RR in hearts...
  46. pmc New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Peptides 32:1551-65. 2011
    Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever...
  47. doi (Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism
    Nicolas Clavreul
    Division of Angiology, Servier Research Institute, Suresnes, France
    Am J Physiol Renal Physiol 300:F1310-8. 2011
    The (pro)renin receptor (PRR) has recently been demonstrated to bind equally well renin and its precursor, prorenin, leading to a similar intracellular signaling independent of angiotensin II...
  48. doi Expression of components of the renin-angiotensin system in proliferating infantile haemangioma may account for the propranolol-induced accelerated involution
    Tinte Itinteang
    School of Biological Sciences, Victoria University of Wellington, and Department of Pathology, Hutt Hospital, Wellington, New Zealand
    J Plast Reconstr Aesthet Surg 64:759-65. 2011
    ..We present here a plausible model involving the renin-angiotensin system that may account for the propranolol-induced accelerated involution of proliferating infantile ..
  49. ncbi Posterior urethral valves: preliminary observations on the significance of plasma Renin activity as a prognostic marker
    Minu Bajpai
    Departments of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India
    J Urol 173:592-4. 2005
    ..Activation of the renin-angiotensin system is known to inflict this injury...
  50. doi Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Circ Heart Fail 2:532-40. 2009
    ..peptide with therapeutic potential in heart failure, and diuretics have opposing effects on renal function and the renin-angiotensin-aldosterone system...
  51. ncbi Role of plasma renin activity in the management of primary vesicoureteric reflux: a preliminary report
    Minu Bajpai
    Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
    Kidney Int 64:1643-7. 2003
    ..In this descriptive study, we report our additional observations on serial measurement of plasma renin activity (PRA) in a group of such children followed prospectively.
  52. ncbi Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells
    B L Jensen
    Institut fur Physiologie I, University of Regensburg, Germany
    Hypertension 29:1148-55. 1997
    ..the secretion of corticotropin and aldosterone and could thereby indirectly influence blood pressure through the renin-angiotensin-aldosterone system...
  53. pmc Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells
    Kenichiro Koda
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
    Circulation 122:771-81. 2010
    b>Renin released by ischemia/reperfusion from cardiac mast cells activates a local renin-angiotensin system (RAS)...
  54. doi The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor?
    A H Jan Danser
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Hypertens Res 33:4-10. 2010
    b>Renin inhibitors, similar to all renin-angiotensin system (RAS) blockers, increase the plasma concentration of renin because they attenuate the negative feedback effect of angiotensin (Ang) II on renin release...
  55. doi Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT)
    Mihai Gheorghiade
    Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 1006, Chicago, IL 60611, USA
    Eur J Heart Fail 13:100-6. 2011
    ..b>Renin-angiotensin-aldosterone system (RAAS) antagonists improve outcomes in outpatients with heart failure (HF) and ..
  56. pmc Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis
    Hong Lu
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Br J Pharmacol 165:2000-8. 2012
    Inhibition of the renin angiotensin system (RAS) has been consistently demonstrated to reduce atherosclerosis...
  57. doi Plasma renin activity for monitoring vesicoureteric reflux therapy: mid-term observations
    Minu Bajpai
    Department of Paediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Pediatr Urol 4:60-4. 2008
    To study plasma renin activity (PRA) as an early marker for monitoring treatment of vesicoureteric reflux (VUR).
  58. ncbi Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
    The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance, as well as arterial pressure...
  59. doi The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
    Basic Res Cardiol 105:725-35. 2010
    ..Activation of the renin-angiotensin-aldosterone system impairs PAC function...
  60. doi Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism
    A Di Murro
    Department of Clinical Sciences, Day Service Secondary of Hypertension, Policlinico Umberto I, Rome, Italy
    J Renin Angiotensin Aldosterone Syst 11:165-72. 2010
    ..to account for blood pressure increases, such as sympathetic nervous system hyperactivity, oxidative stress, renin-angiotensin-aldosterone system (RAAS) activation, endothelin system activation, and endothelial dysfunction...
  61. pmc Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 114:1128-35. 2004
    ..Metabolic and renal histological changes and the renin-Ang system components in the plasma and kidneys were determined at 8, 16, and 24 weeks following streptozotocin ..
  62. doi Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium
    Juan Kong
    Department of Medicine, Division of Biological Sciences, Committee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 74:1577-81. 2008
    ..leads to hyperreninemia independent of calcium metabolism; however, the contribution of parathyroid hormone to renin upregulation remained unclear...
  63. doi Physiology of the (pro)renin receptor: Wnt of change?
    Gabin Sihn
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Kidney Int 78:246-56. 2010
    The (pro)renin receptor is a protein that binds prorenin and renin in tissues, leading to their activation and, at the same time, to the initiation of intracellular signaling...
  64. doi Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes
    Agnieszka Biala
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Blood Press 19:196-205. 2010
    There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure...
  65. ncbi A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
    Jan H Schefe
    Center for Cardiovascular Research Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Circ Res 99:1355-66. 2006
    A human renin/prorenin receptor (RER) has recently been cloned. To gain insight into the molecular function of the RER, we studied its signal transduction mechanisms...
  66. ncbi The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease
    Ursula C Brewster
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Med 116:263-72. 2004
    The renin-angiotensin-aldosterone system regulates renal vasomotor activity, maintains optimal salt and water homeostasis, and controls tissue growth in the kidney...
  67. doi Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 32:1227-34. 2011
    Direct renin inhibitors provide an alternative approach to inhibiting the renin-angiotensin-aldosterone system (RAAS) at the most proximal, specific, and rate-limiting step...
  68. doi Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma
    Christelle Cousin
    Institut National de la Santé et de la Recherche Médicale and Collège de France, Paris, France
    Hypertension 53:1077-82. 2009
    The (pro)renin receptor [(P)RR] is a 35-kDa transmembrane protein that plays a pivotal role in angiotensin tissue generation and in nonproteolytic prorenin activation...
  69. ncbi Developmental programming of renal glucocorticoid sensitivity and the renin-angiotensin system
    Caitlin S Wyrwoll
    School of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Australia
    Hypertension 50:579-84. 2007
    ..receptor, and 11beta-hydroxysteroid dehydrogenase type 2 and components of the intrarenal and adipose renin-angiotensin system...
  70. doi Translational medicine: the antihypertensive effect of renal denervation
    Gerald F DiBona
    University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa, USA
    Am J Physiol Regul Integr Comp Physiol 298:R245-53. 2010
    ..A proof-of-principle study in patients with hypertension resistant to conventional therapy has demonstrated that the procedure is safe and produces renal denervation with sustained lowering of arterial pressure...
  71. ncbi Fetal uninephrectomy leads to postnatal hypertension and compromised renal function
    Karen M Moritz
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia k moritz hfi unimelb edu au
    Hypertension 39:1071-6. 2002
    ..Similar differences were observed in blood pressure and renal function at 12 months of age. Plasma renin concentrations at this age were lower in the uninephrectomized lambs (P<0.05)...
  72. pmc Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase
    Zhongyi Zhang
    Department of Medicine, Division of Biological Sciences, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:15896-901. 2008
    The renin-angiotensin system (RAS) plays a critical role in the development of diabetic nephropathy, and blockade of the RAS is currently used for treatment of diabetic nephropathy...
  73. doi The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis
    Gustavo Adolfo Arganãraz
    Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil
    Epilepsia 49:1348-57. 2008
    ....
  74. pmc Estrogen protects against increased blood pressure in postpubertal female growth restricted offspring
    Norma B Ojeda
    Department of Physiology, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 50:679-85. 2007
    ..05 versus ovariectomized counterpart); renin angiotensin system blockade also abolished ovariectomy-induced hypertension in female growth-restricted offspring (..
  75. ncbi The brain renin-angiotensin system: location and physiological roles
    M J McKinley
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne 3010, Vic, Australia
    Int J Biochem Cell Biol 35:901-18. 2003
    Angiotensinogen, the precursor molecule for angiotensins I, II and III, and the enzymes renin, angiotensin-converting enzyme (ACE), and aminopeptidases A and N may all be synthesised within the brain...
  76. ncbi Screening for primary aldosteronism without discontinuing hypertensive medications: plasma aldosterone-renin ratio
    B J Gallay
    Division of Nephrology, University of California Davis Medical Center, Sacramento, CA, USA
    Am J Kidney Dis 37:699-705. 2001
    ..The plasma aldosterone-renin ratio (ARR) is a valid screening assay for primary aldosteronism, but antihypertensives are usually discontinued ..
  77. pmc Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM U489, and Association Claude Bernard, Hopital Tenon, Paris, France
    J Clin Invest 109:1417-27. 2002
    b>Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors...
  78. ncbi The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms
    L Gendron
    Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Mol Endocrinol 31:359-72. 2003
    ..Based on its altered expression in neurological disorders, a role for the AT(2) receptor in control of neuronal plasticity is proposed...
  79. pmc Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
    Vivek P Singh
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX, USA
    Diabetes 57:3297-306. 2008
    ..In the present study, we determined whether hyperglycemia activates the cardiac intracellular renin-Ang system (RAS) in vivo and whether ARBs, ACE, or renin inhibitors block synthesis and effects of intracellular ..
  80. ncbi Renin release
    Frank Schweda
    Institute of Physiology, University of Regensburg, Germany
    Physiology (Bethesda) 22:310-9. 2007
    The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body...
  81. doi Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?
    Wendy W Batenburg
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Room EE1418b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Hypertension 58:1111-9. 2011
    b>Renin/prorenin binding to the (pro)renin receptor ([P]RR) results in direct (angiotensin-independent) second-messenger activation in vitro, whereas in vivo studies in rodents overexpressing prorenin (≈400-fold) or the (P)RR do not ..
  82. doi (Pro)renin and its receptors: pathophysiological implications
    Wendy W Batenburg
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Clin Sci (Lond) 123:121-33. 2012
    Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]...
  83. pmc The renin-angiotensin system and diabetes: an update
    Antônio Ribeiro-Oliveira
    Laboratorio de Endocrinologia, Departamento de Clinica Medica, Centro Universitário de Belo Horizonte, UNIBH, Belo Horizonte, MG, Brazil
    Vasc Health Risk Manag 4:787-803. 2008
    In the past few years the classical concept of the renin-angiotensin system (RAS) has experienced substantial conceptual changes...
  84. pmc A redox switch in angiotensinogen modulates angiotensin release
    Aiwu Zhou
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nature 468:108-11. 2010
    ..is critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors...
  85. ncbi Obesity-induced hypertension develops in young rats independently of the renin-angiotensin-aldosterone system
    Anita D Smith
    Department of Physiology, Medical College of Georgia, Augusta, 30912 3000, USA
    Exp Biol Med (Maywood) 231:282-7. 2006
    ..measured by tail-cuff, and a terminal blood sample was obtained to measure fasting blood glucose, insulin, plasma renin, aldosterone, thiobarbitutic acid reactive substances (TBARS), and free 8-isoprostanes levels...
  86. pmc Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration
    Hyung Suk Kim
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 99:4602-7. 2002
    ..including a three-fold increase in aldosterone synthase expression in adrenal gland, and a two-fold decrease in renin expression in kidney...
  87. doi Physiology of kidney renin
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Physiol Rev 90:607-73. 2010
    The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which is relevant under both physiological and pathophysiological settings. The kidney is the only organ capable of releasing enzymatically active renin...
  88. doi Effects of low-sodium diet vs. high-sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride (Cochrane Review)
    Niels A Graudal
    Department of Rheumatology TA4242 Internal Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Am J Hypertens 25:1-15. 2012
    ..The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids.
  89. doi Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells
    Ming Lu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Physiol Cell Physiol 302:C59-66. 2012
    The present study aims to investigate the regulatory effect of hydrogen sulfide (H(2)S) on cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. It was found in the present study that NaHS at 0...
  90. pmc Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
    Adam Whaley-Connell
    Research Service, Harry S Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, USA
    Metabolism 62:861-72. 2013
    ..Thereby, we sought to determine if combination of direct renin inhibition with angiotensin type 1 receptor blockade in vivo, through greater reductions in systolic blood ..
  91. pmc The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance
    Justin L Grobe
    Department of Internal Medicine, University of Iowa, Iowa City, 52242, USA
    Cell Metab 12:431-42. 2010
    The renin-angiotensin system (RAS), in addition to its endocrine functions, plays a role within individual tissues such as the brain...
  92. pmc Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
    Kathleen M I Caron
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:3106-11. 2004
    ..Here, we characterize one caused by a well defined single copy transgene, RenTgMK, that genetically clamps plasma renin and thence angiotensin II at high levels...
  93. doi The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?
    K G Pringle
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia
    Placenta 32:956-62. 2011
    The renin-angiotensin system (RAS) is thought to regulate placentation, however, the expression and localization of RAS pathways in early gestation human placenta is not known...
  94. doi Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans
    Thomas Guldager Lauridsen
    Department of Medicine, Department of Medical Research, Regional Hospital Holstebro, Lagaardvej 12, Holstebro, Denmark
    Nephrol Dial Transplant 25:2502-10. 2010
    ....
  95. doi Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Curr Opin Nephrol Hypertens 20:69-76. 2011
    The renin-angiotensin system (RAS) is a treatment target for diabetic retinopathy and possibly other ocular diseases. However, angiotensin II blockade, though beneficial in diabetic retinopathy, is not completely retinoprotective...
  96. pmc The collecting duct is the major source of prorenin in diabetes
    Jung J Kang
    Department of Physiology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hypertension 51:1597-604. 2008
    In addition to the juxtaglomerular apparatus, renin is also synthesized in renal tubular epithelium, including the collecting duct (CD)...
  97. doi (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling
    Oscar Alcazar
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA
    Exp Eye Res 89:638-47. 2009
    The (pro)renin receptor (PRR) is believed to potentiate the renin-angiotensin system (RAS), conferring to prorenin, a likely pathological role at tissue level...
  98. doi Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats
    Chu Lin Chou
    Institute of Medical Sciences, Buddhist Tzu Chi University, Hualien, Taiwan
    Hypertens Res 36:123-8. 2013
    ..and vascular dysfunction in insulin-resistant rats; however, there are few reports on the effects of direct renin inhibitors on these conditions...
  99. ncbi Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
    M H Alderman
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, N Y 10461 1602
    N Engl J Med 324:1098-104. 1991
    To test the prognostic value of plasma renin activity prospectively, we determined the pretreatment renin-sodium profile of 1717 subjects with mild-to-moderate hypertension (mean age, 53 years; 36 percent white; 67 percent men) in a ..
  100. ncbi Prorenin and the (pro)renin receptor: do they have a pathogenic role in the retina?
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Front Biosci (Elite Ed) 2:1054-64. 2010
    Prorenin, the inactive precursor of renin has been suggested to be an indicator of diabetic complications including retinopathy...
  101. pmc Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy
    Bryan R Conway
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Am Soc Nephrol 23:405-11. 2012
    ..Here, we used the Cyp1a1mRen2 rat, in which the murine renin-2 gene is incorporated under the Cytochrome P4501a1 promoter...

Research Grants73

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..We also anticipate that falls in cardiac output and renal hypoperfusion will lead to activation of the renin-angiotensin system, the chronic up- regulation of which has been associated with increased cardiovascular ..
  2. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..centers as well as directly to the kidney;and (3) We will determine the effect of exercise trainin on renin release, plasma and renal tissue Ang II and renal sodium excretion via the distal sodium chloride co-transporter (..
  3. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..Blockade of the renin-angiotensin system with drugs that also lower blood pressure has been shown of benefit in that they slow the rate ..
  4. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..Recent research has implicated a heightened renin-angiotensin-aldosterone system (RAAS) and associated enhanced oxidative stress in the pathogenesis and ..
  5. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..In addition to over-nutrition, several other mechanisms, such as enhanced activation of the renin- angiotensin-system (RAS), inflammation, and associated abnormalities in INS metabolic signaling, may help explain ..
  6. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..Current therapy for hypertension and heart failure, in large part, target the sympathetic nervous system and the renin- angiotensin II system (RAS)...
  7. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ..coagulation, fibrinolysis, platelet function, infection and inflammation, angiogenesis, folate metabolism, and the renin-angiotensin systems that have previously been associated with AP...
  8. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..In addition to our WD, several other mechanisms, such as enhanced activation of the renin-angiotensin-aldosterone-system (RAAS) and associated abnormalities in INS metabolic signaling, may help explain ..
  9. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..The proposed research will test our hypothesis that the intermittent hypoxia of OSA activates the renin-angiotensin-system (RAS) in the carotid body, resulting in increased production of superoxide ion by NADPH oxidase ..
  10. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..animals with the metabolic syndrome display significant coronary dysfunction that is related to activation of the renin-angiotensin system and augmented angiotensin receptor (AT1)-induced coronary microvascular vasoconstriction...
  11. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..Angiotensin II (AngII), the primary effectors peptide of the renin-angiotensin system, plays a critical role in cardiovascular and body fluid homeostasis...
  12. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..20 years in glycemic and blood pressure control, and the introduction of 'renoprotective'drugs such as renin-angiotensin system blockers, the incidence of end-stage renal disease (ESRD) in type 1 diabetes (T1D) is not ..
  13. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..We will also characterize the involvement of the MBL complex and complement in renin-angiotensin system (RAS) activation and cardiac autophagy...
  14. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The importance of the renin angiotensin system in cardiovascular disease has been proven by the positive clinical benefits associated with ACE inhibitors and angiotensin type 1 receptor (AT1R) ..
  15. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..agent specifically designed to slow the progression of CKD to ESRD, other than the use of inhibitors of the renin-angiotensin system...
  16. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..The angiotensin (Ang) converting enzyme (ACE), Ang II and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various cardiovascular diseases including ..
  17. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..20 years in glycemic and blood pressure control, and the introduction of 'renoprotective'drugs such as renin-angiotensin system blockers (RASB), the incidence of end-stage renal disease (ESRD) in type 1 diabetes (T1D) is ..
  18. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..The mechanism by which the renin-angiotensin-aldosterone system (RAAS) affects glucose control remains uncertain...
  19. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..who first established the existence of an internal regulatory mechanism comprising novel proteins of the renin-angiotensin-aldosterone system (RAS) that significantly contribute to the regulation of blood pressure and target ..
  20. ROLE OF ENHANCERS REGULATING RENIN GENE EXPRESSION
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..PROJECT SUMMARY (See instnjctions): The renin-angiotensin system is a major regulator of blood pressure and electrolyte balance in animals and humans and has ..
  21. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..The overall objective of the current application is to determine the role that the local cholangiocyte renin-angiotensin-system (RAS) plays in the maintenance of biliary mass during cholestasis...
  22. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..Blood pressure (BP) in women with PCOS is normalized with renin- angiotensin system (RAS) blockers...
  23. Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance
    SHAWN BRADY BENDER; Fiscal Year: 2013
    ..defect in states of insulin resistance (IR) that are closely associated with inappropriate activation of the renin-angiotensin-aldosterone system (RAAS)...
  24. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..This is supported by the fact that all components of renin-angiotensin system (RAS) are expressed in adipose tissue, obese individuals show upregulation of adipose RAS, and ..
  25. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..using measures derived from fasting insulin and cortisol levels) and circulating levels of aldosterone and renin. Finally, we will examine effects of vitamin D supplementation on the immune response of peripheral blood ..
  26. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ..have identified molecular mechanisms associated with cardiac remodeling, including increased activity of the renin-angiotensin system, changes in nitric oxide (NO) production, and alterations in end-organ sensitivity to ..
  27. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Renin-Angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis...
  28. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ..Among them, elevation of plasma free fatty acids (FFAs) and over-activation of the renin-angiotensin system (RAS) are thought to play pivotal roles in vascular insulin resistance and endothelial ..
  29. Renin-angiotensin and fibrinolysis interaction in humans
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..Our recent data suggest that the effect of interruption of the renin-angiotensin-aldosterone system may depend on the extent to which aldosterone is decreased, as aldosterone ..
  30. Blood Pressure -- Determinants &Controllers
    Allen W Cowley; Fiscal Year: 2012
    ..examines the permissive role that ANGII plays in maintaining normal vascular reactivity and how defects in the SS renin allele lead to increased oxidative stress and impaired vascular relaxation...
  31. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  32. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  33. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..20 years in glycemic and blood pressure control and the introduction of 'renoprotective'drugs such as renin-angiotensin system blockers, the incidence of end-stage renal disease (ESRD) in type 1 diabetes (T1D) is not ..
  34. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2013
    ..Following treatments, proximal tubule NKA activity and various components of the renin angiotensin system will be determined...
  35. Roles for Phospholipase D2 in metabolism and cardiovascular homeostasis
    ROCHELLE NELSON; Fiscal Year: 2013
    ..2 will explore PLD2's potential contribution to the regulation of blood pressure via its involvement in the renin-angiotensin-aldosterone system...
  36. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    ..Evidence from our laboratory and in the recent literature implicate immune cells, cytokines and the renin-angiotensin system in the microvascular dysfunction associated with both HTN and HCh...
  37. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..CaOx crystal deposition in rat kidneys leads to oxidant stress, is associated with the activation of renin-angiotensin system (RAS), and increases in the production of macromolecules such as osteopontin (OPN) that ..
  38. Regulation of Adrenal Vascular Tone by Steroidogenic Cells
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..APA may determine whether ZG cell-mediated EET- and/or endothelial-mediated NO mechanisms oppose the constriction by AII and maintain ABF in high renin states.
  39. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..Project 4 will test whether increased extracellular Ca inhibits renin release by activating Ca sensing receptors on juxtaglomerular cells which increases intracellular Ca and reduces ..
  40. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..DSS) model through blockage of signaling via the inhibition of the angiotensin-converting enzyme (ACE) in the renin-angiotensin system...
  41. PPG-Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..The Program will focus on conditions of activation of the central renin-angiotensin system (RAS) and altered leptin signaling in hypertension and diet-induced obesity (DIG), and on the ..
  42. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    Activation of the renin-angiotensin system (RAS) is associated with increased cardiovascular death. A critical component of this system is angiotensin converting enzyme (ACE), which cleaves angiotensin I to angiotensin II (Angll)...
  43. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2013
    ..mediate podocyte injury and will elucidate interactions between podocyte COX-2 and the local podocyte renin-angiotensin system (RAS) during the development of diabetic nephropathy...
  44. Sodium-chloride co-transporter regulation in the kidney
    Alicia A McDonough; Fiscal Year: 2013
    ..The renin angiotensin system (RAS) stimulates NCC activity via an AngII-WNK4-SPAK dependent pathway...
  45. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..of a new paradigm of ischemic preconditioning, which prevents the activation of a local mast cell-dependent renin- angiotensin system (RAS) and its dysfunctional consequences;and, 2) The inhibition of a previously unsuspected ..
  46. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ-VILLALOBOS; Fiscal Year: 2013
    ..The kidneys posses all the components of the renin-angiotensin system and therefore are capable of synthesizing Ang II...
  47. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..pathways governing AA formation remain poorly understood, accumulating evidence implicates activation of the renin-angiotensin system (RAS) as an important contributor to the pathogenesis of AA disease...
  48. Regulatory Functions of APE1 - An Essential Repair Protein
    Sankar Mitra; Fiscal Year: 2010
    ..co-factor (in acetylated form) in repressing negative Ca2+ response element (nCaRE)-dependent parathyroid, renin, and possibly other genes...
  49. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2013
    ..in patients and animal models with hypertension or heart failure, conditions marked by hyper-activation of the renin-angiotensin II (Ang II) signaling axis and elevated reactive oxygen species (ROS)...
  50. Redox Modification of the Arrhythmic Substrate in Heart Failure
    RAIMOND LESTER WINSLOW; Fiscal Year: 2013
    ..2 billion. Treatment of this disease with 2-blockers and/or inhibitors of renin-angiotensin signaling has decreased mortality and morbidity over the years, but mortality still approaches 60% ..
  51. CVD protection mechanisms involving ACE2/Ang-(1-7) axis
    Mohan K Raizada; Fiscal Year: 2013
    ..provide experimental evidence for our hypothesis, (ii) establish mechanisms by which ACE2/Ang- (1-7) axis of the renin-angiotensin system produces cardiovascular protective effects, (iii) "backward- translational" studies will ..
  52. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..in control rats and in 2-kidney-1 clip (2K-1C) hypertensive rats, a clinically-relevant model of humoral (renin)-dependent hypertension...
  53. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Angiotensinogen (Ao) and other components of the local cardiac renin-angiotensin system (RAS) are upregulated in the hemodynamically overloaded heart...
  54. Role of micro RNAs in renin cell differentiation
    ROBERTO ARIEL GOMEZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Renin, the key hormone of the renin-angiotensin system, regulates blood pressure and fluid-electrolyte homeostasis...
  55. Angiotensin II, IGF-1 and Skeletal Muscle Atrophy
    Patrice Delafontaine; Fiscal Year: 2013
    ..In these conditions the renin-angiotensin system (RAS) is often activated...
  56. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
    ..so that loss of AhR increases the sensitivity to hypoxia-induced ET-1expression, leading to activation of the renin-angiotensin system (RAS), hypertension and organ damage via induction of reactive oxygen species (ROS)...
  57. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ..cells induces hypertension and exposure of mice to an individual chemical in TS may lead to activation of the renin-angiotensin system (RAS), a major regulator of vascular function and blood pressure...
  58. Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    DOMINIC JAMES SMIRAGLIA; Fiscal Year: 2013
    ..for pancreatic islet cell carcinoma as a result of cell-specifically deleting floxed Rb and p53 loc within the renin- expressing cell compartment of pancreas...
  59. MODifiable Effectors of Renin System Activation: Treatment Evaluation
    John P Forman; Fiscal Year: 2013
    ..Both lower 25-hydroxyvitamin D (25[OH]D) and higher uric acid levels are associated with activation of the renin angiotensin system, endothelial dysfunction, and elevation of blood pressure in humans...
  60. Cytokines and Sympathetic Activation in Heart Failure
    Robert B Felder; Fiscal Year: 2013
    ..pro-inflammatory cytokines increase sympathetic nerve activity in heart failure rats by upregulating the brain renin-angiotensin system and the production of angiotensin II, which is sympatho-excitatory in the brain in its own ..
  61. OXIDATIVE STRESS IN THE KIDNEY IN HYPERTENSION
    Christopher S Wilcox; Fiscal Year: 2013
    ..of pressure into the kidney and hence increases the set point of BP regulation together with increased release of renin and an increased re-absorption of NaCl by the tubules which underlies salt sensitivity...
  62. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..Despite widespread use of intensive glycemic control and renin-angiotensin-aldosterone system inhibitors, renal and cardiovascular consequences of DKD remain common...
  63. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    Upregulation of the renin-angiotensin system and increased vasoconstrictive response to angiotensin II (AngII) are observed during hypertension in pregnancy (HTN-Preg) and preeclampsia...
  64. CALCIUM AND CONTROL OF RENIN SECRETION
    John Fray; Fiscal Year: 1990
    The long-term objective of this research project is to identify and define the regulation of renin secretion (RS) at the cellular level...
  65. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..Since a critical role of the intrarenal renin-angiotensin system (RAS) in regulation of renal function is now established, the overall objective of the proposed ..
  66. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..goal of this application is to define the role of vitamin D and parathyroid hormone (PTH) in the regulation of the renin-angiotensin system in vivo, which plays a crucial role in the regulation of blood pressure, electrolyte and volume ..
  67. CELLULAR MECHANISMS FOR ANGIOTENSIN RESPONSES IN BRAIN
    ELISABETH TALLANT; Fiscal Year: 1999
    The central renin-angiotensin system (RAS) participates in the control of arterial pressure. Angiotensin (Ang) II receptors are present on neurons, astrocytes and vascular elements and likely cooperate in this regulation...
  68. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009
    ..inhibitor therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
  69. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..While recent randomized clinical trials indicate interruption of the renin-angiotensin-aldosterone system by either ACE inhibition or ATi receptor antagonism decreases the incidence of ..
  70. ALDOSTERONE, RENIN AND PROSTAGLANDINS IN MAN
    Richard Horton; Fiscal Year: 1980
    ..asks for support of our ongoing research in the inter-relationships between vasodepressor prostaglandins, renin-aldosterone, renal function, and vascular reactivity in man...
  71. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    ..While the renin angiotensin system (RAS) has traditionally been viewed as a circulating axis, evidence is accumulating that an ..
  72. REGULATION OF CARDIAC SECOND MESSENGERS BY ANGIOTENSIN
    Kenneth Baker; Fiscal Year: 1993
    The renin-angiotensin system is a major regulator of fluid and volume homeostasis in mammalian species...
  73. TRANSGENIC IN HYPERTENSION--RAS RIBOZYNE INHIBITION
    John Mullins; Fiscal Year: 1992
    ..These techniques, once established with the key genes of the renin angiotensin system, will in principle be applicable universally to any other gene...