carnitine o palmitoyltransferase

Summary

Summary: An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. EC 2.3.1.21.

Top Publications

  1. ncbi Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification
    Clinton R Bruce
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst
    Am J Physiol Endocrinol Metab 292:E1231-7. 2007
  2. pmc Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    Blake B Rasmussen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 110:1687-93. 2002
  3. ncbi Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan
    Biofactors 13:9-14. 2000
  4. ncbi In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 296:E738-47. 2009
  5. pmc Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
    Clinton R Bruce
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:550-8. 2009
  6. ncbi Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
    J A Simoneau
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec
    FASEB J 13:2051-60. 1999
  7. ncbi Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    R L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75235 9135, USA
    Diabetes 50:123-30. 2001
  8. ncbi A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria
    Shannon E Campbell
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 279:36235-41. 2004
  9. ncbi Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids
    G K Totland
    Department of Zoology, University of Bergen, Norway
    Biol Cell 92:317-29. 2000
  10. ncbi Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E803-8. 2001

Research Grants

Detail Information

Publications236 found, 100 shown here

  1. ncbi Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification
    Clinton R Bruce
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst
    Am J Physiol Endocrinol Metab 292:E1231-7. 2007
    ..05). These studies demonstrate that acute overexpression of CPT I in muscle leads to a repartitioning of FAs away from esterification and toward oxidation and highlight the importance of CPT I in regulating muscle FA metabolism...
  2. pmc Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    Blake B Rasmussen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 110:1687-93. 2002
    ..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle...
  3. ncbi Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan
    Biofactors 13:9-14. 2000
    ..It was suggested that both substrate specificities and alterations in the activities of the enzymes in beta-oxidation pathway play a significant role in the regulation of the serum lipid concentrations in rats fed alpha-18:3...
  4. ncbi In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 296:E738-47. 2009
    ..The additional fatty acid taken up is channeled primarily to esterification, suggesting that upregulation in fatty acid transport as opposed to altered fatty acid oxidation is the major determinant of intramuscular lipid accumulation...
  5. pmc Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
    Clinton R Bruce
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:550-8. 2009
    ....
  6. ncbi Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
    J A Simoneau
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec
    FASEB J 13:2051-60. 1999
    ....
  7. ncbi Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    R L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75235 9135, USA
    Diabetes 50:123-30. 2001
    ..In conclusion, either a diet rich in saturated fat or prolonged inhibition of fatty acid oxidation impairs IMGD in rats via a mechanism related to the accumulation of IMCL...
  8. ncbi A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria
    Shannon E Campbell
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 279:36235-41. 2004
    ....
  9. ncbi Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids
    G K Totland
    Department of Zoology, University of Bergen, Norway
    Biol Cell 92:317-29. 2000
    ..In the group treated with EPA a lower areal fraction of fat droplets was observed, while the DHA group was similar to the control. This indicates that EPA and DHA have different effects on mitochondrial biogenesis...
  10. ncbi Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
    S E Campbell
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 281:E803-8. 2001
    ..01); however, treatment with E(2) returned beta-HAD activity to C levels. These results suggest that E(2) plays a role in lipid metabolism by increasing the maximal activity of key enzymes in the fat oxidative pathway of skeletal muscle...
  11. ncbi CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance
    David Sebastian
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E 08028, Spain
    Am J Physiol Endocrinol Metab 292:E677-86. 2007
    ..These results suggest that LCPT I overexpression protects L6E9 myotubes from fatty acid-induced insulin resistance by inhibiting both the accumulation of lipid metabolites and the activation of PKCtheta and PKCzeta...
  12. ncbi Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    H Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 279:E806-14. 2000
    ....
  13. ncbi Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
    Clinton R Bruce
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Am J Physiol Endocrinol Metab 291:E99-E107. 2006
    ....
  14. ncbi Reduced plasma free fatty acid availability during exercise: effect on gene expression
    Rebecca J Tunstall
    School of Exercise and Nutritional Sciences, Deakin University, 221 Burwood Highway, Burwood, Vic, 3125, Australia
    Eur J Appl Physiol 99:485-93. 2007
    ....
  15. ncbi FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle
    Graham P Holloway
    1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R960-7. 2009
    ..Nevertheless, the KO animals reveal that FAT/CD36 contributes to the regulation of mitochondrial fatty acid oxidation, which is especially important for meeting the increased metabolic demands during muscle contraction...
  16. pmc Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 586:1755-66. 2008
    ..Moreover, these studies identify for the first time a mechanism by which rosiglitazone stimulates fatty acid oxidation in skeletal muscle, namely the chronic, subcellular relocation of FAT/CD36 to mitochondria...
  17. ncbi Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function
    V Esser
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 268:5817-22. 1993
    ..They also establish unequivocally that CPT I and CPT II are distinct proteins and that inhibitors of CPT I interact within its catalytic domain, not with an associated regulatory component...
  18. ncbi Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
    Feike R van der Leij
    Department of Pediatrics, Groningen University Institute for Drug Exploration, University of Groningen and Beatrix Children s Hospital, Groningen 9700RB, The Netherlands
    J Biol Chem 277:26994-7005. 2002
    ..Therefore, the involvement of splice variation of M-CPT I in the modulation of malonyl-CoA inhibition of fatty acid oxidation may be less relevant than hitherto assumed...
  19. pmc Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion
    Blanca Rubi
    Department of Biochemistry and Molecular Biology, University of Barcelona, School of Pharmacy, Diagonal 643, E 08028 Barcelona, Spain
    Biochem J 364:219-26. 2002
    ..They also indicate that up-regulation of CPT I contributes to the loss of response to high glucose in beta-cells exposed to fatty acids...
  20. ncbi Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Nat Genet 40:1324-8. 2008
    ....
  21. ncbi Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
    Veronic Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 290:E509-15. 2006
    ....
  22. ncbi Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae
    C Prip-Buus
    Endocrinologie, Métabolisme et Développement, CNRS UPR 1524, 9, Meudon Bellevue, France
    FEBS Lett 429:173-8. 1998
    ..Thus, the expression in S. cerevisiae is a valid model to study the structure-function relationships of L-CPT 1...
  23. ncbi Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
    M Alegret
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Diabetes 50:1883-90. 2001
    ..These changes may be involved in the reduction in fat depots and in the improvement of insulin sensitivity observed after bezafibrate treatment...
  24. ncbi Changes in the expression of hypothalamic lipid sensing genes in rat model of intrauterine growth retardation (IUGR)
    Antonella Puglianiello
    Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy
    Pediatr Res 61:433-7. 2007
    ..05) and beta (p=0.005) were significantly decreased. The data presented here support the hypothesis that an abnormal intrauterine milieu can induce changes in hypothalamic lipid sensing...
  25. pmc Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells
    David Sebastian
    Departments of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Barcelona, Spain
    J Lipid Res 50:1789-99. 2009
    ..However, etomoxir, an irreversible inhibitor of CPT1, blocked all these effects. These data reveal that FATP1, like FAT/CD36, is associated with mitochondria and has a role in mitochondrial oxidation of fatty acids...
  26. ncbi Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I
    N Yamazaki
    Faculty of Pharmaceutical Sciences, University of Tokushima, Japan
    Biochim Biophys Acta 1307:157-61. 1996
    ..By Northern analysis, we confirmed the dominant expression of this isoform in heart and skeletal muscle...
  27. ncbi Genomic DNA sequence, promoter expression, and chromosomal mapping of rat muscle carnitine palmitoyltransferase I
    D Wang
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston 77030, USA
    Genomics 48:314-23. 1998
    ..The muscle specificity of the 5' flanking region was verified by comparison of luciferase expression to that of beta-galactosidase in cardiac myocytes and in HepG2 cells...
  28. ncbi A novel brain-expressed protein related to carnitine palmitoyltransferase I
    Nigel Price
    Hannah Research Institute, Ayr, KA6 5HL, UK
    Genomics 80:433-42. 2002
    ..Thus this new CPT I related protein may be specialized for the metabolism of a distinct class of fatty acids involved in brain function...
  29. pmc Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene
    C H Britton
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 92:1984-8. 1995
    ....
  30. ncbi High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA clone
    N Yamazaki
    Faculty of Pharmaceutical Sciences, University of Tokushima, Japan
    FEBS Lett 363:41-5. 1995
    ..The transcript corresponding to this cDNA was found to be abundantly expressed in BAT and heart. Therefore, the isolated clone is concluded to encode a CPTI like protein expressed in BAT and heart...
  31. ncbi Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training
    Simon Schenk
    Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, 401 Washtenaw Ave, Ann Arbor, MI 48109 2214, USA
    Am J Physiol Endocrinol Metab 291:E254-60. 2006
    ..857, P < 0.003). In conclusion, the findings from this study indicate that exercise training alters the localization of FAT/CD36 and increases its association with CPT I, which may help augment fat oxidation...
  32. ncbi Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure
    S L Kennedy
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Appl Physiol 90:17-22. 2001
    ..These data suggest that acclimatization to high altitude selectively decreases key enzymes in fat utilization and oxidation in the heart, liver, and select skeletal muscles...
  33. ncbi Evaluation of liver fatty acid oxidation in the leptin-deficient obese mouse
    Amy E Brix
    Departments of Genomics and Pathobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Genet Metab 75:219-26. 2002
    ..In summary, despite obese mice having an excess of fat available for mitochondrial beta-oxidation in liver, overall energy balance appeared to dictate that the net liver FAO remained at control levels...
  34. ncbi Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle
    Jong Yeon Kim
    Department of Biochemistry, East Carolina University, Greenville, North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 282:E1014-22. 2002
    ..These results provide evidence of a malonyl-CoA-insensitive CPT I activity in red muscle, suggesting fiber type-specific expression of distinct CPT I isoforms and/or posttranslational modulations that have yet to be elucidated...
  35. ncbi Long-chain fatty acid uptake and oxidation in the perfused liver of Walker-256 tumour-bearing rats
    Christiame Vicentino
    Laboratory of Liver Metabolism, University of Maringa, 87020900 Maringa, Brazil
    Liver 22:341-9. 2002
    ..The effect of the Walker-256 tumour on uptake and oxidation of long-chain fatty acids was investigated in perfused livers of rats...
  36. ncbi Dietary fat has minimal effects on fatty acid metabolism transcript concentrations in pigs
    S T Ding
    USDA, ARS, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030 2600, USA
    J Anim Sci 81:423-31. 2003
    ..Also, in porcine adipose tissue, as well as in liver and skeletal muscle, these transcripts are rather refractory to modification by dietary FA...
  37. ncbi Vitamin A deficiency modifies lipid metabolism in rat liver
    Liliana B Oliveros
    Laboratory of Biological Chemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Avenida Ejército de los Andes 954, 5700 San Luis, Argentina
    Br J Nutr 97:263-72. 2007
    ..The incorporation of vitamin A into the diet of vitamin A-deficient rats reverted all the changes observed...
  38. ncbi Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
    Arzu Onay-Besikci
    Department of Pharmacology, University of Alberta, Edmonton, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 284:H283-9. 2003
    ..Our data suggest that a decrease in malonyl CoA control of CPT-1 is primarily responsible for the increase in fatty acid oxidation seen in the newborn heart...
  39. ncbi Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle
    Tiina Tyni
    Department of Neurology, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Pediatr Res 52:64-70. 2002
    ..Measurement of fatty acid oxidation intermediates from myoblasts or myotubes is an additional tool in investigating pathogenetic mechanisms of myopathy in beta-oxidation defects...
  40. ncbi Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
    ..Furthermore, the present results also indicate that an increased carnitine biosynthesis also contributes to the clofibrate-induced increase in hepatic carnitine concentration...
  41. ncbi [Identification of muscle-type carnitine palmitoyltransferase I and characterization of its gene structure]
    Naoshi Yamazaki
    Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima 770 8505, Japan
    Yakugaku Zasshi 124:893-908. 2004
    ..The physiologic role(s) of these transcripts is still unknown. However, it is interesting that such transcripts are produced from two tightly arranged and functionally unrelated genes in mammalian tissues...
  42. ncbi A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
    David Cameron-Smith
    School of Health Sciences, Deakin University, Burwood, Victoria, Australia
    Am J Clin Nutr 77:313-8. 2003
    ..Dietary fatty acids may be important in regulating gene expression. However, little is known about the effect of changes in dietary fatty acids on gene regulation in human skeletal muscle...
  43. ncbi Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression
    Claude Kohl
    Endocrinologie et Metabolisme, Institut Cochin, INSERM U567, Paris, France
    Diabetes 51:2363-8. 2002
    ..In conclusion, this work suggests that benfluorex mainly via S 422-1 reduces gluconeogenesis by affecting gene expression and metabolic status of hepatocytes...
  44. ncbi Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italia
    FASEB J 17:1112-4. 2003
    ..The data also show that MTE I and UCP3 are likely involved in the same biochemical mechanism and that UCP3 postulated functions, such as lipid handling and uncoupling, are not mutually exclusive but may coexist in vivo...
  45. ncbi Pulling in more fat
    David E Kelley
    Department of Medicine, University of Pittsburgh Medical Center, Montefiore Hospital, Pittsburgh, Pennsylvania 15213, USA
    Cell Metab 2:275-6. 2005
    ..In obesity, skeletal muscle accumulates triglyceride. Recent work from Hulver and colleagues (2005) in the October issue of Cell Metabolism implicates stearoyl-CoA desaturase as part of the underlying molecular mechanism...
  46. pmc Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle
    Seung Hun Cha
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:14557-62. 2005
    ..These findings clarify the mechanism by which the hypothalamic malonyl-CoA signal is communicated to metabolic systems in skeletal muscle that regulate fatty acid oxidation and energy expenditure...
  47. ncbi The role of the carnitine system in human metabolism
    Daniel W Foster
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9030, USA
    Ann N Y Acad Sci 1033:1-16. 2004
    ..Activation of fatty acid oxidation has considerable clinical promise for the treatment of obesity, type 2 diabetes, steatohepatitis, and lipotoxic damage to the heart...
  48. ncbi 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats
    Antonia Lanni
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Caserta, Italy
    FASEB J 19:1552-4. 2005
    ..However, the results reported here do not exclude deleterious effects of T2 on a longer time scale as well as do not show that T2 acts in the same way in humans...
  49. ncbi Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout
    Zhen Yu Du
    Universite de Bourgogne, 21000 Dijon, France
    Lipids 39:849-55. 2004
    ..The data strongly suggest that the induction of peroxisomal activities, some of which being able to oxidize very long chain FA, was responsible for the lower contents of EPA and DHA in the body lipids of fenofibrate-treated trout...
  50. ncbi Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster
    M Teresa Macarulla
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of Pais Vasco, Vitoria, Spain
    Nutrition 21:512-9. 2005
    ..The present work was designed to study the effects of the two main isomers of conjugated linoleic acid (CLA), cis-9,trans-11 and trans-10,cis-12, on liver composition and hepatic fatty acid oxidation in hamsters...
  51. ncbi Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid
    Yohanes Buang
    Department of Applied Biological Sciences, Saga University, Saga, Japan
    Nutrition 21:867-73. 2005
    ..We compared the effect of dietary phosphatidylcholine (PC) with that of triacylglycerol (TG), both with the same fatty acid profiles, on fatty infiltration in orotic acid (OA)-induced fatty liver of Sprague-Dawley rats...
  52. ncbi Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria
    E Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    FEBS Lett 579:1639-45. 2005
    ..We suggest that T3 stimulates the UCP3 activity in vivo by affecting the complex network of biochemical pathways underlying the UCP3 activation...
  53. ncbi Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation
    V Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    FASEB J 19:977-9. 2005
    ..In conjunction with our observed increases in CoA and carnitine in muscle of Ucp3 overexpressors, the findings support the hypothesized role for Ucp3 in facilitating fatty acid oxidation in muscle...
  54. ncbi Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Can J Physiol Pharmacol 83:183-90. 2005
    ..Despite normalization of cardiac metabolism, PPARalpha treatment did not improve cardiac function in diabetic hearts...
  55. ncbi [The influence of panthotenic acid mitochondrial oxidation and oxidative phosphorylation in liver of rats with alimentary obesity]
    E E Naruta
    Vopr Pitan 73:3-7. 2004
    ....
  56. ncbi An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A
    Laura Napal
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
    J Mol Biol 354:751-9. 2005
    ..These results corroborate the hypothesis that PPARalpha regulates the limiting step in the oxidation of fatty acids in liver mitochondria...
  57. ncbi Influence of DMBA-induced mammary cancer on the liver CPT I, mit HMG-CoA synthase and PPARalpha mRNA expression in rats fed a low or high corn oil diet
    Raquel Moral
    Department of Cell Biology, Physiology and Immunology, Medical Physiology Unit, School of Medicine, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Int J Mol Med 14:283-7. 2004
    ..This effect of the cancer state could be related to tumor aggressiveness and suggest a preferential redirection of long-chain fatty acids into energetic and specific pathways of the cancer cells...
  58. ncbi Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity
    Wen Guo
    Evans Department of Medicine, Obesity Research Center, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 292:E1041-51. 2007
    ..Thus preadipocyte fatty acid handling changes with aging, with increased susceptibly to lipotoxicity and impaired fatty acid-induced adipogenesis and beta-oxidation...
  59. ncbi Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    Silvana Obici
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Med 9:756-61. 2003
    ....
  60. ncbi Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
    Myeong Jin Yoon
    Department of Biological Sciences, Seoul National University, Gwanak Gu, Seoul 151 742, Korea
    Diabetes 55:2562-70. 2006
    ..Taken together, these results suggest that adiponectin stimulates fatty acid oxidation in muscle cells by the sequential activation of AMPK, p38 MAPK, and PPARalpha...
  61. ncbi Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid
    P Degrace
    UPRES Lipides et Nutrition EA2422, Faculte des Sciences Gabriel, Universite de Bourgogne, 21000 Dijon, France
    J Nutr 134:861-7. 2004
    ..These data indicate that FA oxidation capacities were increased in mice fed CLA2, but were likely depressed in vivo through malonyl-CoA inhibition...
  62. ncbi Age-associated changes in fat metabolism in the rat and its relation to sympathetic activity
    So Young Park
    Department of Physiology, College of Medicine, Yeungnam University, Daegu, South Korea
    Life Sci 79:2228-33. 2006
    ..Increased sympathetic activity may be the compensatory response and the reduced capacity of fatty acid oxidation is a main cause of obesity...
  63. ncbi Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrier
    Alessandra Ferramosca
    Department of Sciences and Biological and Environmental Technologies, University of Lecce, 73100 Lecce, Italy
    J Lipid Res 47:1994-2003. 2006
    ..These data indicate that the CIC may play a role in the onset of hepatic steatosis in CLA-fed mice by supplying the carbon source for de novo fatty acid synthesis...
  64. ncbi Activation of leptin expression by an inhibitor of carnitine palmitoyltransferase-1
    P Wolkowicz
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Obes Relat Metab Disord 28:649-51. 2004
    ..These results support the conclusion that CPT1-linked fatty acid oxidation is a key modulator of leptin expression in fasting rats...
  65. ncbi Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat
    Pascal Degrace
    UPRES Lipides et Nutrition EA2422, Faculte des Sciences Gabriel, Universite de Bourgogne, Dijon, France
    Mol Cell Biochem 258:171-82. 2004
    ..All the inductions related to fatty acid transport, oxidation and esterification most likely stem from the abundance of blood lipids providing cardiomyocytes with more fatty acids...
  66. pmc The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:7282-7. 2006
    ..CPT1c KO mice also exhibit decreased rates of fatty acid oxidation, which may contribute to their increased susceptibility to diet-induced obesity. These findings indicate that CPT1c is necessary for the regulation of energy homeostasis...
  67. ncbi Effects of soybean beta-conglycinin on hepatic lipid metabolism and fecal lipid excretion in normal adult rats
    Kensuke Fukui
    Food Science Research Institute, Fuji Oil Co, Ltd, Osaka, Japan
    Biosci Biotechnol Biochem 68:1153-5. 2004
    ..Fecal fatty acid excretion in the beta-conglycinin group was significantly higher than in the casein group...
  68. ncbi Phenotype-based treatment of dietary obesity: differential effects of fenofibrate in obesity-prone and obesity-resistant rats
    Hong Ji
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Metabolism 54:421-9. 2005
    ..These results suggest that enhancement of mitochondrial fatty acid oxidation in liver may be an effective phenotype-based treatment strategy for dietary obesity...
  69. ncbi Activation of AMP-activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin-sensitizing effects of troglitazone in skeletal muscle cells
    S Fediuc
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Cell Physiol 215:392-400. 2008
    ..These effects seem to be at least partially dependent on AMPK activation and may account for potential acute PPAR-gamma-independent anti-diabetic effects of thiazolidinediones in skeletal muscle...
  70. ncbi Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia
    Y Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    J Biol Chem 276:5629-35. 2001
    ..We conclude that a physiologic role of the hyperleptinemia of caloric excess is to protect nonadipocytes from steatosis and lipotoxicity by preventing the up-regulation of lipogenesis and increasing fatty-acid oxidation...
  71. ncbi Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis
    Masafumi Uno
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Hepatology 48:109-18. 2008
    ..Most of these effects were observed in LETO rats and OLETF rats, which suggest that the action of tranilast is mediated through the insulin resistance-independent pathway...
  72. ncbi Lipid storage myopathies
    Claudio Bruno
    Muscular and Neurodegenerative Disease Unit, Giannina Gaslini Institute, Genova, Italy
    Curr Opin Neurol 21:601-6. 2008
    ..The aim of this review is to provide an update on disorders of lipid metabolism affecting skeletal muscle exclusively or predominantly and to summarize recent clinical, genetic, and therapeutic studies in this field...
  73. pmc Crocetin improves the insulin resistance induced by high-fat diet in rats
    L Sheng
    Department of Pharmacology, China Pharmaceutical University, Nanjing, PR China
    Br J Pharmacol 154:1016-24. 2008
    ..The present study is designed to clarify the insulin-sensitizing mechanism of crocetin by elucidating the mechanism of regulation of lipid metabolism by crocetin...
  74. ncbi Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats
    S M Rahman
    Department of Applied Biological Sciences, Saga University, Saga, Japan
    Nutrition 17:385-90. 2001
    ..Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA...
  75. ncbi The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects
    J Bremer
    Institute of Medical Biochemistry, University of Oslo, Pb 1112 Blindern, 0317, Oslo, Norway
    Prog Lipid Res 40:231-68. 2001
    ....
  76. ncbi A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
    MAJA STEFANOVIC-RACIC
    Department of Medicine, Division of Endocrinology, University of Pittsburg, Pittsburgh, PA, USA
    Am J Physiol Endocrinol Metab 294:E969-77. 2008
    ..Therefore, interventions that increase CPT-1a activity could have potential benefits in the treatment of NAFLD...
  77. ncbi Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis
    Mikael Lehtihet
    Dept of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 285:E438-46. 2003
    ....
  78. ncbi Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity
    J N Thupari
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochem Biophys Res Commun 285:217-23. 2001
    ..This study identifies CPT-1 and ACC as two new potential targets for cancer chemotherapy...
  79. ncbi Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice
    Jaume Amengual
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Obesity (Silver Spring) 16:585-91. 2008
    ..The objective of this study has been to investigate the effect of ATRA treatment on skeletal muscle capacity for fatty-acid catabolism...
  80. ncbi Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells
    A S Pimenta
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Cell Physiol 217:478-85. 2008
    ....
  81. ncbi The effects of the inhibition of fatty acid oxidation on pyruvate dehydrogenase complex activity in tissues of lean and obese mice
    J M Bryson
    Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Int J Obes Relat Metab Disord 20:738-44. 1996
    ..To investigate the effects of an acute dose of the fatty acid oxidation inhibitor, Etomoxir, on the activity of the pyruvate dehydrogenase complex (PDHC) in different tissues in lean and obese mice...
  82. ncbi Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 294:H954-60. 2008
    ....
  83. ncbi Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2 1 2 Kannondai, Tsukuba Science City, Japan
    Biochim Biophys Acta 1485:23-35. 2000
    ..Dietary perilla oil and fish oil therefore exert similar physiological activity in modulating hepatic fatty acid oxidation, but these dietary fats considerably differ in affecting fatty acid synthesis...
  84. ncbi Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
    Ines Pineda Torra
    U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 17:259-72. 2003
    ..These results provide molecular evidence for a cross-talk between the FXR and PPARalpha pathways in humans...
  85. ncbi Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program
    T H Zytkovicz
    New England Newborn Screening Program, University of Massachusetts Medical School, Jamaica Plain, 305 South St, Jamaica Plain, MA 02130, USA
    Clin Chem 47:1945-55. 2001
    ..Limited information is available for setting the marker cutoffs and for the resulting positive predictive values...
  86. ncbi Ultra-fast simultaneous detection of obesity-related coenzymes in mice using microchip electrophoresis with a LIF detector
    Hee Gu Lee
    Cellomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
    Anal Chim Acta 619:94-100. 2008
    ..Moreover, the amplified RT-PCR products of the obesity-related coenzymes in C57BL/6J mice were analyzed using only sub-micro liter samples...
  87. ncbi PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes
    Yeon Seok Seo
    Department of Internal Medicine, Korea University College of Medicine, Guro Hospital, Seoul, Korea
    J Gastroenterol Hepatol 23:102-9. 2008
    ....
  88. ncbi 3-Thia fatty acid treatment, in contrast to eicosapentaenoic acid and starvation, induces gene expression of carnitine palmitoyltransferase-II in rat liver
    L Madsen
    Department of Clinical Biochemistry, Haukeland Hospital, University of Bergen, Norway
    Lipids 34:447-56. 1999
    ..It is suggested that fatty acids are partly oxidized in the peroxisomes before entering the mitochondria as acylcarnitines for further oxidation...
  89. ncbi Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha
    David M Selva
    Child and Family Research Institute, British Columbia, Canada
    J Mol Endocrinol 43:19-27. 2009
    ....
  90. ncbi Diagnostic assessment and long-term follow-up of 13 patients with Very Long-Chain Acyl-Coenzyme A dehydrogenase (VLCAD) deficiency
    Pascal Laforet
    Centre de Référence de Pathologie Neuromusculaire Paris Est, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Neuromuscul Disord 19:324-9. 2009
    ..Measurement of fasting blood acylcarnitines by tandem mass spectrometry allows accurate biochemical diagnosis and should therefore be performed in all patients presenting with unexplained muscle exercise intolerance or rhabdomyolysis...
  91. ncbi Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations
    E Verderio
    Divisione di Biochimica e Genetica, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Hum Mol Genet 4:19-29. 1995
    ..Finally, immunoblot analysis demonstrated that both mutations were associated with markedly reduced steady-state level of the protein, thus indicating decreased stability of the mutant CPT II...
  92. ncbi Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers
    Aya Matsusue
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Leg Med (Tokyo) 13:7-11. 2011
    ..However, there were no significant mutations that reduced enzyme activity in the suspected cases of rhabdomyolysis. These data suggested no obvious relationship between the genetic mutations observed in this study and rhabdomyolysis...
  93. ncbi Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    S Gremlich
    Institute of Pharmacology and Toxicology, University of Lausanne, 27, Rue du Bugnon, CH 1005 Lausanne, Switzerland
    J Biol Chem 272:30261-9. 1997
    ..Fatty acids thus have pleiotropic effects on pancreatic islet gene expression, and the negative control of Idx-1 expression may be an initial event in the development of these multiple defects...
  94. ncbi Fatty acid oxidation disorders: outcome and long-term prognosis
    Bridget Wilcken
    Biochemical Genetics and Newborn Screening, The Children s Hospital at Westmead, Westmead, NSW, Australia
    J Inherit Metab Dis 33:501-6. 2010
    ..Late-onset CPT II is characterised only by episodic rhabdomyolysis on severe exercise. CPT type IA deficiency may often be benign, although early presentation with hypoketotic hypoglycaemia certainly occurs...
  95. ncbi Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    J C Fruchart
    Department of Atherosclerosis, INSERM U325, Pasteur Institute, University of Lille II, France
    Curr Opin Lipidol 10:245-57. 1999
    ....
  96. ncbi Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition
    Montserrat Morillas
    Department of Biochemistry and Molecular Biology, University of Barcelona, School of Pharmacy, E 08028 Barcelona, Spain
    J Biol Chem 278:9058-63. 2003
    ..Ariño, J., Valencia, A., Hegardt, F. G., Serra, D., and Asins, G. (2002) J. Biol. Chem. 277, 11473-11480). Met(593) may participate in the interaction of malonyl-CoA in the second affinity site, whose location has not been reported...
  97. ncbi Central administration of corticotropin-releasing factor induces thermogenesis by changes in mitochondrial bioenergetics in neonatal chicks
    A Mujahid
    Laboratory of Advanced Animal and Marine Bioresources, Faculty of Agriculture, Kyushu University, 6 10 1, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Neuroscience 155:845-51. 2008
    ....
  98. ncbi Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytes
    Paola Priore
    Laboratory of Biochemistry, Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, 73100 Lecce, Italy
    Biochim Biophys Acta 1771:1299-307. 2007
    ..Overall, our results suggest that increased fatty acid oxidation with consequent decreased fatty acid availability for TAG synthesis is a potential mechanism by which CLA reduce TAG level in rat liver...
  99. ncbi Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice
    N M Morton
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Rd S, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 276:41293-300. 2001
    ..Further, 11beta-HSD-1(-/-) mice have improved glucose tolerance. These data suggest that 11beta-HSD-1 deficiency produces an improved lipid profile, hepatic insulin sensitization, and a potentially atheroprotective phenotype...
  100. ncbi Carnitine acyltransferase enzymic catalysis requires a positive charge on the carnitine cofactor
    A Saeed
    Department of Chemistry, University of Alabama at Birmingham 35294
    Arch Biochem Biophys 305:307-12. 1993
    ..Since the observed Ki values are significantly larger than the Km for carnitine, the positive charge on carnitine must also be important, but not essential, for binding to the carnitine site on carnitine acyltransferases...
  101. ncbi Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids
    Gustavo J Hein
    Departamento de Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina
    Am J Physiol Endocrinol Metab 298:E429-39. 2010
    ....

Research Grants37

  1. GENETIC SUSCEPTIBILITY TO LIPID-LOWERING DRUG-INDUCED MYOPATHIES
    GEORGIRENE VLADUTIU; Fiscal Year: 2012
    ..abstract_text> ..
  2. NMR OF MITOCHONDRIAL TRANSPORTERS IN CARDIAC HYPERTROPHY
    E Douglas Lewandowski; Fiscal Year: 2013
    ....
  3. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..The findings of these studies will help to characterize the defects in energy metabolism in the failing heart and aid in the design of therapies that improve energy transduction in the failing human heart. ..
  4. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..The significance of this research is that the results may provide potentially useful information concerning the dietary management of CHD...
  5. CARNITINE PALMITOYLTRANSFERASE I AND THE GERM CELL
    Victoria Esser; Fiscal Year: 2004
    ..On the other hand, a reversible CPT I inhibitor that could be targeted to the testis or ovary might well find use as a male or female contraceptive agent. ..
  6. REGULATING MYOCARDIAL FATTY ACID OXIDATION IN DIABETES
    GEORGE COOK; Fiscal Year: 2003
    ..abstract_text> ..
  7. Activators of Adipocyte Fatty Acid Oxidation
    CYDNEY BROOKS; Fiscal Year: 2003
    ..Development of such compounds may lead to therapeutic interventions that are effective for modulating lipid metabolism and treating obesity. ..
  8. CARNITINE PALMITOYLTRANSFERASE I ISOFORM FUNCTION
    Tod Gulick; Fiscal Year: 2005
    ....
  9. Regulation of Cardiac Carnitine Palmitoyltransferase I
    Gebre Woldegiorgis; Fiscal Year: 2004
    ..The M-CPTI null mice will allow us to construct models that mimic human CPT deficiency diseases and to look for potential gene therapy through retro-transfection of the normal CPT gene. ..
  10. MITOCHONDRIAL OXIDATIVE ENZYME EXPRESSION
    Tod Gulick; Fiscal Year: 2000
    ....
  11. Lipid Kinetics During Acute Exercise in HIV
    William Cade; Fiscal Year: 2004
    ..Body composition will be examined using DEXA and 1H-MRI. Intra-myocellular and hepatic lipid content will be measured using 1H-MRS. ..
  12. Novel Small Molecule Therapeutics to Treat Obesity
    ALBERT OWENS; Fiscal Year: 2004
    ..abstract_text> ..
  13. STUDIES OF FAS INHIBITION IN HUMAN BREAST CANCER CELLS
    FRANCIS KUHAJDA; Fiscal Year: 2003
    ..These studies will advance our understanding of the action of FAS inhibition, further the development of this pathway for drug development, and likely lead to additional novel therapeutic targets. ..
  14. CNS Fatty Acid Metabolism in Regulation of Food Intake
    Susan Aja; Fiscal Year: 2007
    ..We will measure changes in intracellular AMP/ATP ratio and activity of AMP-activated protein kinase, levels of mRNAs for feeding-related neuropeptides, and neuropeptide production and release. ..
  15. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  16. Genetics of Lipoproteins in Afro-Caribbean Families
    Iva Miljkovic Gacic; Fiscal Year: 2007
    ..Our long-term goal is to dissect the genetic architecture of traditional and nuclear magnetic spectroscopy (NMR) measured lipoprotein phenotypes in extended, multi-generational families of African heritage. [unreadable] [unreadable]..
  17. HORMONAL CONTROL OF ADIPOSE GENE EXPRESSION
    M Lane; Fiscal Year: 2007
    ..The 32kDa CUP/AP-2alpha- interacting protein, p32, previously identified in our lab, will be characterized and its role determined. ..
  18. AMP Activated Kinase in Neurons
    Gabriele Ronnett; Fiscal Year: 2008
    ..Aim 2 will study the role and regulation of AMPK in an ischemia-reperfusion model. Aim 3 will determine the mechanisms by which modulation of the FAS and CPT-1 activities alters AMPK activity and affords neuroprotection. ..
  19. Long-term follow-up of postobese black and white women
    Barbara Gower; Fiscal Year: 2008
    ..abstract_text> ..
  20. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
    ..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
  21. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2010
    ..The proposed studies will provide additional rationale for convincing a predominantly sedentary population of the importance of regular exercise in combating inactivity-related diseases. ..
  22. Reduced Carbohydrate Diet Intervention for PCOS
    Barbara A Gower; Fiscal Year: 2010
    ..the lower GL diet will be more effective in decreasing insulin secretion, increasing insulin sensitivity, decreasing ectopic adipose tissue, decreasing inflammation, and improvin% (<10% saturated fat) saturated fat) ..
  23. The Role of KLF6 Tumor Suppressor in Hepatocellular Cancer
    SCOTT LAURENCE FRIEDMAN; Fiscal Year: 2010
    ..abstract_text> ..
  24. Intramuscular lipid and insulin action: ethnic aspects
    Barbara Gower; Fiscal Year: 2006
    ..abstract_text> ..
  25. Physiology of Malonyl-CoA in Muscle during Exercise
    WILLIAM WINDER; Fiscal Year: 2006
    ..The results will provide additional rationale for the use of regular exercise in preventing and treating type 2 diabetes and obesity. ..
  26. GLUCOSE UTILIZATION IN SENESCENT HEARTS
    Rong Tian; Fiscal Year: 2002
    ..Aim 4: To test the hypothesis that presence of high glucose and insulin increase glucose utilization and improves the tolerance toischemia in senescent hearts. ..
  27. CARNITINE PALMITOYLTRANSFERASE AND FATTY ACID METABOLISM
    Daniel Foster; Fiscal Year: 2002
    ....
  28. OLFACTORY NEURONS: A MODEL FOR NEUROTROPHIN FUNCTION
    Gabriele Ronnett; Fiscal Year: 2004
    ..Understanding these mechanisms is essential to our ability to manipulate that process. ..
  29. ETHNIC DIFFERENCES IN INSULIN SENSITIVITY
    Barbara Gower; Fiscal Year: 2003
    ..The chronic hyperinsulinemia that results from this defect will ultimately result in peripheral (skeletal muscle) insulin resistance. ..
  30. Fatty Acid Synthase Inhibition and Neuronal Metabolism
    Gabriele Ronnett; Fiscal Year: 2005
    ..In Aim III we will test the hypothesis that those pathways are relevant in vivo by modulating these signaling pathways in the presence of C75 and determining which pathways affect feeding and weight loss. ..
  31. Antiadipogenic Influence of HIV Protease Inhibitors
    M Lane; Fiscal Year: 2005
    ..The long term objective of the proposed research is to facilitate the design of anti-HIV therapeutics that lack lipoatrophic potential. ..
  32. MAGNETIC RESONANCE CARDIAC C13FLUX AND METABOLIC RATE
    E Lewandowski; Fiscal Year: 2001
    ..The long range objective is the ultimate use of C13 NMR to assess the activity and expression of these mitochondrial proteins that regulate metabolic flux in intact and in vivo organs during development and disease. ..
  33. Olfactory Neurons--Model for PACAP Neurotrophic Function
    Gabriele Ronnett; Fiscal Year: 2005
    ..These studies will elucidate the function and mechanisms underlying bioactive peptide neurotrophism in the CNS. ..
  34. REGULATION OF TRIACYLGLYCEROL METABOLISM IN OBESITY
    Labros Sidossis; Fiscal Year: 2001
    ..The studies employ stable and radioactive isotopes for kinetic measurements and involve detailed physiologic and kinetic mathematical modeling. ..
  35. Metabolic enzyme activity mediating myocardial stunning
    E Lewandowski; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  36. FACTORS AND GENES RESPONSIBLE FOR ADIPOCYTE COMMITMENT
    M Lane; Fiscal Year: 2006
    ..abstract_text> ..
  37. REGULATION OF LIPOGENESIS
    M Lane; Fiscal Year: 2001
    ..for derepression and repression of the SCD1 and SCD2 genes. ..