griseofulvin

Summary

Summary: An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.

Top Publications

  1. ncbi [Modern antimycotics. What the treating physician needs to know]
    C Seebacher
    Dresden, Germany
    Hautarzt 55:150-6. 2004
  2. ncbi Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells
    Y S Ho
    Institute of Biomedical Technology, Taipei Medical College, Taipei, Taiwan
    Int J Cancer 91:393-401. 2001
  3. ncbi Efficacy of topical griseofulvin in treatment of tinea corporis
    Mohamed A A Kassem
    Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Mycoses 49:232-5. 2006
  4. ncbi Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells
    Mads H Rønnest
    Department of Chemistry, Technical University of Denmark, Kemitorvet, Building 201, DK 2800 Kgs Lyngby, Denmark
    J Med Chem 52:3342-7. 2009
  5. ncbi Live-cell imaging of tubulin in the filamentous fungus Magnaporthe grisea treated with anti-microtubule and anti-microfilament agents
    Kirk J Czymmek
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    Protoplasma 225:23-32. 2005
  6. ncbi Hepatic damage and oxidative stress induced by Griseofulvin in mice
    M del C Martinez
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Cell Mol Biol (Noisy-le-grand) 55:127-39. 2009
  7. pmc Enhanced oral bioavailability of griseofulvin via niosomes
    Pratap S Jadon
    Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar, 470 003, India
    AAPS PharmSciTech 10:1186-92. 2009
  8. ncbi The effect of griseofulvin on the gene regulation of beta-tubulin in the dermatophyte pathogen Trichophyton rubrum
    Kamiar Zomorodian
    Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    J Infect Chemother 13:373-9. 2007
  9. ncbi Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole
    L Dastghaib
    Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
    J Dermatolog Treat 16:43-6. 2005
  10. ncbi Alteration of mRNA levels of delta-aminolevulinic acid synthase, ferrochelatase and heme oxygenase-1 in griseofulvin induced protoporphyria mice
    K Inafuku
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    J Dermatol Sci 19:189-98. 1999

Research Grants

Detail Information

Publications209 found, 100 shown here

  1. ncbi [Modern antimycotics. What the treating physician needs to know]
    C Seebacher
    Dresden, Germany
    Hautarzt 55:150-6. 2004
    ..Preadolescent children do not have functioning sebaceous glands; this explains the difficulties in the treatment of pediatric tinea capitis...
  2. ncbi Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells
    Y S Ho
    Institute of Biomedical Technology, Taipei Medical College, Taipei, Taiwan
    Int J Cancer 91:393-401. 2001
    ..that apoptosis and G2/M cell cycle arrest were easily induced by treatment with the oral-antifungal agent, griseofulvin (GF)...
  3. ncbi Efficacy of topical griseofulvin in treatment of tinea corporis
    Mohamed A A Kassem
    Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Mycoses 49:232-5. 2006
    Tinea infections are among the most common dermatological conditions throughout the world. Griseofulvin is a classical oral fungistatic antibiotic, active against Epidermophyton floccosum, Trichophyton and Microsporum species, the ..
  4. ncbi Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells
    Mads H Rønnest
    Department of Chemistry, Technical University of Denmark, Kemitorvet, Building 201, DK 2800 Kgs Lyngby, Denmark
    J Med Chem 52:3342-7. 2009
    b>Griseofulvin was identified as an inhibitor of centrosomal clustering in a recently developed assay...
  5. ncbi Live-cell imaging of tubulin in the filamentous fungus Magnaporthe grisea treated with anti-microtubule and anti-microfilament agents
    Kirk J Czymmek
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    Protoplasma 225:23-32. 2005
    ..Treatment with either benomyl or griseofulvin resulted in the appearance of prominent brightly fluorescent aggregates, including a large aggregate near the ..
  6. ncbi Hepatic damage and oxidative stress induced by Griseofulvin in mice
    M del C Martinez
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Argentina
    Cell Mol Biol (Noisy-le-grand) 55:127-39. 2009
    ..In some cases, a severe hepatic failure and cholestasis was observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in animals...
  7. pmc Enhanced oral bioavailability of griseofulvin via niosomes
    Pratap S Jadon
    Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar, 470 003, India
    AAPS PharmSciTech 10:1186-92. 2009
    ..was to develop nonionic surfactant vesicles (niosomes) to improve poor and variable oral bioavailability of griseofulvin. Niosomes were prepared by using different nonionic surfactants span 20, span 40, and span 60...
  8. ncbi The effect of griseofulvin on the gene regulation of beta-tubulin in the dermatophyte pathogen Trichophyton rubrum
    Kamiar Zomorodian
    Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    J Infect Chemother 13:373-9. 2007
    b>Griseofulvin - a mold metabolite produced by Penicillium griseofulvum - is an antifungal drug whose interaction with tubulin is poorly understood...
  9. ncbi Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole
    L Dastghaib
    Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
    J Dermatolog Treat 16:43-6. 2005
    Tinea capitis is a relatively common fungal infection of childhood. Griseofulvin has been the mainstay of treatment for many years. However, newer oral antifungal agents are being used more frequently.
  10. ncbi Alteration of mRNA levels of delta-aminolevulinic acid synthase, ferrochelatase and heme oxygenase-1 in griseofulvin induced protoporphyria mice
    K Inafuku
    Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    J Dermatol Sci 19:189-98. 1999
    ..inherited disorder of porphyrin metabolism and its experimental murine model can be produced by treatment with griseofulvin (GF)...
  11. ncbi Preparation and in vivo evaluation of solid lipid nanoparticles of griseofulvin for dermal use
    Nidhi Aggarwal
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    J Biomed Nanotechnol 9:564-76. 2013
    b>Griseofulvin-loaded solid lipid nanoparticles (SLNs) were prepared by hot microemulsion technique and optimized for type and concentration of lipid and surfactant...
  12. ncbi The effect of water-soluble polymers, PEG and PVP, on the solubilisation of griseofulvin in aqueous micellar solutions of Pluronic F127
    Cristiane P Oliveira
    Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceara, CX 6 021, CEP 60455 760, Fortaleza, Ceara, Brazil
    Int J Pharm 421:252-7. 2011
    ..enhancing the solubilisation capacity of micellar solutions of Pluronic F127 for the poorly water-soluble drug griseofulvin by co-formulating with a water-soluble polymer...
  13. ncbi Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce
    Xuekui Xia
    School of Chemistry and Chemical Engineering, Sun Yatsen University, Guangzhou, P R China
    Planta Med 77:1735-8. 2011
    ..2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic ..
  14. ncbi Microtubule assembly dynamics: an attractive target for anticancer drugs
    Parminder Singh
    School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India
    IUBMB Life 60:368-75. 2008
    ..Benomyl, griseofulvin, and sulfonamides have been used as antifungal and antibacterial drugs...
  15. pmc Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine
    Krishnan Rathinasamy
    Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra India
    BMC Cancer 10:213. 2010
    b>Griseofulvin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice...
  16. ncbi Therapeutic options for the treatment of tinea capitis caused by Trichophyton species: griseofulvin versus the new oral antifungal agents, terbinafine, itraconazole, and fluconazole
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, Toronto, Canada
    Pediatr Dermatol 18:433-8. 2001
    Tinea capitis is a relatively common fungal infection of childhood. Griseofulvin has been the mainstay of management. However, newer oral antifungal agents are being used more frequently...
  17. ncbi Effect of the melt granulation technique on the dissolution characteristics of griseofulvin
    Dong Yang
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Int J Pharm 329:72-80. 2007
    ..a melt granulation technique to improve the dissolution characteristics of a poorly water-soluble drug, griseofulvin. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a ..
  18. ncbi Griseofulvin versus terbinafine in the treatment of tinea capitis: a meta-analysis of randomized, clinical trials
    David Fleece
    Department of Pediatrics, Temple University Children s Medical Center, 5th Floor, 3509 N Broad St, Philadelphia, PA 19140, USA
    Pediatrics 114:1312-5. 2004
    ..Although the current treatment of choice is oral griseofulvin, terbinafine has been shown to be variably effective in several comparative, randomized trials...
  19. ncbi Preparation of griseofulvin nanoparticles from water-dilutable microemulsions
    Michele Trotta
    Dipartimento di Scienza e Tecnologia del Farmaco, via P Giuria 9, Torino 10125, Italy
    Int J Pharm 254:235-42. 2003
    Nanoparticles of griseofulvin, a model drug with poor solubility and low bioavailability, were prepared from water dilutable microemulsions by the solvent diffusion technique...
  20. ncbi Production of griseofulvin nanoparticles using supercritical CO(2) antisolvent with enhanced mass transfer
    P Chattopadhyay
    Department of Chemical Engineering, Auburn University, Auburn, AL 36839-5127, USA
    Int J Pharm 228:19-31. 2001
    b>Griseofulvin (GF) is a poor water soluble, antifungal agent. The bioavailability of the drug and its absorption from the gastrointestinal tract can be greatly improved by particle size reduction...
  21. ncbi Improving the high variable bioavailability of griseofulvin by SEDDS
    Adi Issam Arida
    Faculty of Pharmacy, Philadelphia University PO Box 1, Postal Code 19392, Jordan
    Chem Pharm Bull (Tokyo) 55:1713-9. 2007
    To enhance the dissolution and oral absorption of poorly water-soluble griseofulvin (GF), self-emulsifying drug delivery system (SEDDS) composed of oil, surfactant and cosurfactant for oral administration of griseofulvin was formulated, ..
  22. ncbi In vivo efficacy of griseofulvin against multiple myeloma
    Young Kim
    Department of Internal Medicine III, Center for Integrated Oncology, University of Bonn, Bonn, Germany
    Leuk Res 35:1070-3. 2011
    We recently confirmed that ciclopirox olamine inhibits Wnt/beta catenin signalling in myeloma. Griseofulvin (GF) has similar chemical features as compared to ciclopirox olamine. In this study the anti-tumor effect of GF was investigated...
  23. ncbi Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides
    Masataka Saito
    School of Pharmaceutical Science, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Pharm 249:71-9. 2002
    To improve the solubility of poorly water-soluble drugs, we studied physical characteristics of griseofulvin (GF) solid dispersions with saccharides as the dispersion carrier using a roll mixing method...
  24. ncbi Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury
    Anne Marie Fortier
    Molecular oncology and endocrinology research group, Department of Chemistry Biology, University of Quebec at Trois Rivieres, 3351 Blv Des Forges, Trois Rivieres, Quebec, Canada G9A 5H7
    Exp Mol Pathol 89:117-25. 2010
    ..Treatment of mice with a diet containing griseofulvin induces the formation of Mallory-Denk bodies in hepatocytes...
  25. ncbi Preparation and characterization of poly-epsilon-caprolactone nanoparticles containing griseofulvin
    Zohra Zili
    Laboratoire de Pharmacie Galenique, Faculte de Pharmacie, Rue Avicenne, 5000 Monastir, Tunisie
    Int J Pharm 294:261-7. 2005
    b>Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this work was to prepare poly-epsilon-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and to characterize them...
  26. ncbi Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials
    Boni E Elewski
    Department of Dermatology, University of Alabama, Birmingham, Alabama 35294 0009, USA
    J Am Acad Dermatol 59:41-54. 2008
    Although griseofulvin is currently considered the primary antifungal agent used to treat tinea capitis in many countries, increasingly higher doses and longer durations of treatment are becoming necessary to achieve effective treatment...
  27. ncbi Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen
    Blanka Rebacz
    Clinical Cooperation Unit for Molecular Hematology Oncology, German Cancer Research Center DKFZ and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer Res 67:6342-50. 2007
    ..Screening of this compound library led to the identification of griseofulvin, which induced multipolar spindles by inhibition of centrosome coalescence, mitotic arrest, and subsequent cell ..
  28. ncbi NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells
    Yih Huei Uen
    Department of Surgery, Chi Mei Foundational Medical Center, Yung Kang City, Tainan, Taiwan
    J Cell Biochem 101:1165-75. 2007
    b>Griseofulvin (GF), an oral antifungal agent, has been shown to exert antitumorigenesis effect through G2/M cell cycle arrest in colon cancer cells. But the underlying mechanisms remained obscure...
  29. ncbi Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometry
    K E Petit
    SMAB Substances Marines à Activité Biologique, Universite de Nantes, ISOMer, Faculte de Pharmacie, BP 53 508, 44035 Nantes Cedex 01, France
    J Microbiol Methods 58:59-65. 2004
    ..of a monocharged ion at m/z 353 containing a chlorine atom, which could be attributed to the antifungal griseofulvin [C17H17ClO6+H]+...
  30. ncbi A randomized, double-blind, parallel-group, duration-finding study of oral terbinafine and open-label, high-dose griseofulvin in children with tinea capitis due to Microsporum species
    J Lipozencic
    Department of Dermatology and Venereology, University Hospital Center, Zagreb, Croatia
    Br J Dermatol 146:816-23. 2002
    ..However, the optimal treatment duration for its use in the treatment of tinea capitis caused by Microsporum species has not yet been determined...
  31. ncbi Griseofulvin induces mitotic delay and aneuploidy in bone marrow cells of orally treated mice
    Francesca Pacchierotti
    Section of Toxicology and Biomedical Sciences, ENEA CR Casaccia, Via Anguillarese 301, 00060 Santa Maria di Galeria, Roma, Italy
    Mutagenesis 17:219-22. 2002
    b>Griseofulvin (GF) is a fungicide drug well characterized for its aneugenic activity in vitro. In vivo strong evidence of aneuploidy and polyploidy induction has been obtained in germ cells, especially in oocytes...
  32. ncbi Efficacy of itraconazole, terbinafine, fluconazole, griseofulvin and ketoconazole in the treatment of Scopulariopsis brevicaulis causing onychomycosis of the toes
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, and University of Toronto, Ont, Canada
    Dermatology 202:235-8. 2001
    ..Scopulariopsis brevicaulis is a common non-dermatophyte mould that can cause onychomycosis...
  33. ncbi Comparison of terbinafine and griseofulvin in the treatment of tinea capitis
    H Caceres-Rios
    Department of Pediatric Dermatology, Instituto de Salud del Niño, Peru
    J Am Acad Dermatol 42:80-4. 2000
    b>Griseofulvin has been used for many years in the treatment of tinea capitis. Increase in resistance to this medication has led to a search for new therapeutic alternatives.
  34. ncbi Griseofulvin micronization and dissolution rate improvement by supercritical assisted atomization
    E Reverchon
    Dipartimento di Ingegneria Chimica e Alimentare, Universita di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    J Pharm Pharmacol 56:1379-87. 2004
    Supercritical assisted atomization (SAA) was used to micronize griseofulvin (GF), selected as a model compound, to verify the performance of this innovative process...
  35. ncbi A randomized, comparative trial of treatment of kerion celsi with griseofulvin plus oral prednisolone vs. griseofulvin alone
    I Hussain
    Department of Dermatology, King Edward Medical College Mayo Hospital, Lahore, Pakistan
    Med Mycol 37:97-9. 1999
    ..In this randomized study, the efficacy of combination therapy with oral griseofulvin and oral prednisolone (n =17) was compared to oral griseofulvin alone (n=13) in the treatment of kerion celsi...
  36. ncbi Oral griseofulvin remains the treatment of choice for tinea capitis in children
    M L Bennett
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Pediatr Dermatol 17:304-9. 2000
    Tinea capitis is one of the most common infections of children. The standard treatment is griseofulvin. Itraconazole and terbinafine have in large part replaced griseofulvin in the treatment of onychomycosis and, in addition to ..
  37. ncbi Meta-analysis: griseofulvin efficacy in the treatment of tinea capitis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    J Drugs Dermatol 7:369-72. 2008
    Despite its long history in clinical use, reported efficacy rates of griseofulvin remain highly variable. A meta-analysis of clinical trials of griseofulvin use in tinea capitis was performed to determine mean griseofulvin efficacy...
  38. ncbi In vitro and in vivo evaluation of a fast-disintegrating lyophilized dry emulsion tablet containing griseofulvin
    Iman Saad Ahmed
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El Eini St, Cairo, Egypt
    Eur J Pharm Sci 32:58-68. 2007
    ..lyophilized dry emulsion (LDE) tablet that enhanced the in vitro dissolution and in vivo absorption of griseofulvin (GF) is presented...
  39. pmc Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum
    Yit Heng Chooi
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Chem Biol 17:483-94. 2010
    ..and biologically active polyketides: the tetracycline-like viridicatumtoxin 1 and the classic antifungal agent griseofulvin 2...
  40. ncbi A randomized comparison of 4 weeks of terbinafine vs. 8 weeks of griseofulvin for the treatment of tinea capitis
    L C Fuller
    Department of Dermatology, King's College Hospital, London SE5 9RS, UK
    Br J Dermatol 144:321-7. 2001
    ..S.A. The current licensed treatment in children is griseofulvin 10 mg kg(-1) daily, which is usually given for 6--8 weeks...
  41. pmc Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer
    Dulal Panda
    School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay 400076, India
    Proc Natl Acad Sci U S A 102:9878-83. 2005
    The antifungal drug griseofulvin inhibits mitosis strongly in fungal cells and weakly in mammalian cells by affecting mitotic spindle microtubule (MT) function...
  42. ncbi Morphogenesis during division and griseofulvin-induced changes of the microtubular cytoskeleton in the parasitic protist, Trichomonas vaginalis
    C Noel
    Institut Pasteur, Unité Mixte INSERM IPL U547, 1 rue du Professeur Calmette, B P 245, 59019, Lille Cedex, France
    Parasitol Res 89:487-94. 2003
    ..Observation of griseofulvin-treated T...
  43. ncbi Clinico-myocological profile of tinea capitis in North India and response to griseofulvin
    A Singal
    Department of Dermatology, University of College of Medical Sciences, New Delhi, India
    J Dermatol 28:22-6. 2001
    There is a paucity of literature on tinea capitis from North India. The response to griseofulvin has not been studied as well...
  44. ncbi Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin
    A Naseem
    Biomedical Materials Research Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK
    Int J Pharm 269:443-50. 2004
    ..was investigated as a possible technique for increasing the dissolution rate of the poorly soluble drug griseofulvin. Plasma is a partially ionised gas consisting of ions, electrons and neutral species...
  45. ncbi The effects of inhibition of haem biosynthesis by griseofulvin on intestinal iron absorption
    Abas H Laftah
    Department of Clinical Biochemistry, GKT School of Medicine and Dentistry, Bessemer Rd, London SE5 9PJ, UK
    Basic Clin Pharmacol Toxicol 94:161-8. 2004
    ..intestinal iron absorption in mice was investigated by ascertaining the effect of the haem synthesis inhibitor, griseofulvin, on duodenal iron absorption using both in vivo and in vitro measurements...
  46. ncbi [Griseofulvin]
    M Develoux
    Service de Parasitologie Mycologie, Hopital Tenon, 4, rue de la Chine, 75020 Paris
    Ann Dermatol Venereol 128:1317-25. 2001
    b>Griseofulvin is a metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years...
  47. ncbi Poly(lactide)-poly(ethylene glycol) micelles as a carrier for griseofulvin
    E Pierri
    Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rion 26500, Greece
    J Biomed Mater Res A 75:639-47. 2005
    In this work, the feasibility to develop micelle carriers of griseofulvin based on PLA-PEG copolymers was investigated...
  48. ncbi A randomized controlled trial assessing the efficacy of fluconazole in the treatment of pediatric tinea capitis
    K Wade Foster
    Department of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 0009, USA
    J Am Acad Dermatol 53:798-809. 2005
    b>Griseofulvin is considered first-line therapy for tinea capitis, and the Physician's Desk Reference currently recommends 11 mg/kg per day microsize formulation for use in children...
  49. ncbi Tinea capitis
    Marcy S Alvarez
    Department of Dermatology, Lutheran Medical Center, Brooklyn, New York, USA
    Cutis 78:189-96. 2006
    ..The prevalence of TC has risen in the past 2 decades. Griseofulvin, the gold standard of therapy, does not cure about 20% of patients with TC, which has led to recent clinical ..
  50. ncbi Scalp ringworm
    Anthony Summers
    University Hospital Lewisham, London
    Emerg Nurse 14:18-9. 2006
  51. ncbi The systemic treatment of onychomycosis
    Jay A Wenig
    Clin Podiatr Med Surg 21:579-89, vi. 2004
    The systemic treatment of fungal infections has changed considerably over the past 10 to 20 years. Though griseofulvin was introduced in the late 1950s and was at the time the only Food and Drug Administration (FDA)-approved drug in the ..
  52. pmc Isolation of Trichophyton violaceum and Trichophyton soudanense in Baltimore, Maryland
    Shelley S Magill
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1830 E Monument St, 4th Floor, Baltimore, MD 21205, USA
    J Clin Microbiol 45:461-5. 2007
    ....
  53. ncbi Tinea capitis
    Claus Seebacher
    J Dtsch Dermatol Ges 4:1085-91. 2006
  54. ncbi Tinea capitis favosa in Poland
    W Niczyporuk
    Department of Dermatology and Venerology Medical Academy, Bialystok, Poland
    Mycoses 47:257-60. 2004
    ..We describe two patients who had local alopecia caused by Trichophyton schoenleinii. In the first case, we observed good clinical response after griseofulvin treatment and in the second case after topical application of ciclopirox cream.
  55. ncbi Oral treatments for toenail onychomycosis: a systematic review
    Fay Crawford
    The Dental Health Services Research Unit, The University of Dundee, Park Place, Dundee DD1 4MR, Scotland
    Arch Dermatol 138:811-6. 2002
    ..To identify and synthesize the evidence for the efficacy of oral treatments for fungal infections of the toenails...
  56. ncbi In vitro methods for antifungal susceptibility testing of Trichophyton spp
    Maria Elisabete da Silva Barros
    Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos, 6627 PO Box 486 CEP 31 270 901, Belo Horizonte, Minas Gerais, Brazil
    Mycol Res 110:1355-60. 2006
    ..Although the modifications introduced did not interfere with the results, more studies are necessary to establish a standard technique to test susceptibility of dermatophytes to antifungal drugs...
  57. ncbi In vitro susceptibility of Microsporum canis and other dermatophyte isolates from veterinary infections during therapy with terbinafine or griseofulvin
    B Hofbauer
    Infectious Diseases Department, Novartis Research Institute, Vienna, Austria
    Med Mycol 40:179-83. 2002
    ..n = 300) were obtained from naturally infected cats and dogs undergoing oral therapy with terbinafine or griseofulvin. M. canis comprised 92% of isolates; other species included Microsporum gypseum and Trichophyton mentagrophytes...
  58. ncbi Invitro drug sensitivity of Trichophyton species against griseofulvin and ketoconazole
    Sumita Dodia
    Department of Botany, St John s College, Agra 282 002, India
    Hindustan Antibiot Bull 44:47-8. 2002
    The in vitro activity of griseofulvin and ketoconazole was investigated against Trichophyton mentagrophytes (Robin) Blanchard and T. Simii (Pinoy) Stockdale, Mackenzie and Austwick...
  59. ncbi Treatment of dermatophytosis in dogs and cats: review of published studies
    Karen A Moriello
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Vet Dermatol 15:99-107. 2004
    ..Animals or hairs were either bathed or rinsed once or twice weekly. Itraconazole, griseofulvin and terbinafine were evaluated in controlled or field studies, most commonly involving cats...
  60. ncbi [Diversified treatments of Tinea unguium]
    Tomoo Fukuda
    Department of Dermatology, Kyorin University School of Medicine, 20 2, 6 Chome, Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Nihon Ishinkin Gakkai Zasshi 43:85-9. 2002
    ..Many patients dropped out, still having affected nails. It seems important to us to understand thoroughly the merits and demerits of each diversified treatment for tinea unguium and to provide the preferential treatment for each patient...
  61. ncbi Treatment of dermatophyte toenail onychomycosis in the United States. A pharmacoeconomic analysis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook campus and University of Toronto, Ontario, Canada
    J Am Podiatr Med Assoc 92:272-86. 2002
    ..nail lacquer and the oral agents terbinafine, itraconazole (pulse), itraconazole (continuous), fluconazole, and griseofulvin. A treatment algorithm for the management of onychomycosis was developed, and a meta-analysis was carried out ..
  62. ncbi Black-dot tinea capitis. Patchy hair loss is common in pediatric patients
    Robert T Brodell
    Northeastern Ohio Universities College of Medicine, Rootstown, USA
    Postgrad Med 111:123-6. 2002
  63. ncbi First-line treatment for tinea capitis
    Eduardo S Diehl
    Pediatr Dermatol 22:372; author reply 372. 2005
  64. ncbi Tinea capitis mimicking dissecting cellulitis: a distinct variant
    Joy M Twersky
    Department of Dermatology, University of Cincinnati, Division of Pediatric Dermatology, Cincinnati Children s Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Int J Dermatol 44:412-4. 2005
    ..Tinea capitis is a common scalp dermatosis with several clinical patterns. Only two patients with a presentation of tinea capitis mimicking dissecting cellulitis have been described in the English literature...
  65. ncbi Tinea capitis update: a continuing conflict with an old adversary
    B K Chen
    Pediatric and Adolescent Dermatology, Children's Hospital, San Diego, California, USA
    Curr Opin Pediatr 13:331-5. 2001
    ..Clinical studies over the past decade that have investigated the response of tinea capitis to griseofulvin, the mainstay treatment for this condition, suggest a decrease in sensitivity to this pharmacologic agent, in ..
  66. ncbi Current topics of tinea capitis in China
    Jin Yu
    Department of Dermatology Research Center of Medical Mycology, Peking University First Hospital, Beijing 100034, PR China
    Nihon Ishinkin Gakkai Zasshi 46:61-6. 2005
    ..The major etiologic agent of tinea capitis varies in different areas. Tinea capitis in China has unique characteristics. The epidemiology, transmission and therapy of child and adult tinea capitis in China are reviewed in this paper...
  67. ncbi Tinea capitis: a treatment update
    Brandie J Roberts
    Children s Hospital and Health Center and University of California San Diego Medical Center, San Diego, CA, USA
    Pediatr Ann 34:191-200. 2005
    Currently, many experts consider griseofulvin to be the drug of choice for tinea capitis. It is FDA approved for this indication, highly efficacious, and has an excellent long-term safety record...
  68. ncbi [Systematic treatment of tinea pedis--evidence for treatment? A result of a Cochrane review]
    Merete Haedersdal
    Dermatologisk afdeling D 92, H S Bispebjerg Hospital, DK 2400 København NV
    Ugeskr Laeger 165:1436-8. 2003
    ..Once acquired the infection can spread to other sites including the nails, which can be a source of reinfection. Oral therapy is usually used for chronic conditions or when topical treatment has failed...
  69. ncbi Systemic antifungal therapy for cutaneous infections in children
    Aisha Sethi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    Pediatr Infect Dis J 25:643-4. 2006
  70. ncbi An overview of antifungal drugs and their use for treatment of deep and superficial mycoses in animals
    Richard F Hector
    Institute for Global Health, University of California San Francisco, San Francisco, CA 94105, USA
    Clin Tech Small Anim Pract 20:240-9. 2005
    ....
  71. pmc Voriconazole susceptibilities of dermatophyte isolates obtained from a worldwide tinea capitis clinical trial
    M Ghannoum
    Center for Medical Mycology, University Hospital of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Microbiol 44:2579-80. 2006
    ..obtained from a worldwide tinea capitis trial were compared to their susceptibilities to fluconazole and griseofulvin. The MIC ranges of voriconazole, fluconazole, and griseofulvin, were 0.002 to 0.06 microg/ml, 0...
  72. ncbi Increasing tinea capitis prevalence in Stockholm reflects immigration
    Jenny Hallgren
    Department of Dermatology and Venereology, Department of Clinical Microbiology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Med Mycol 42:505-9. 2004
    ..The treatment consisted of the oral antimycotics terbinafine (n = 48) or griseofulvin (n = 49)...
  73. ncbi In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan
    Mostafa Chadeganipour
    Mycology and Parasitology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Mycoses 47:503-7. 2004
    ..verrucosum, Microsporum canis and Epidermophyton floccosum were examined for their susceptibility to griseofulvin. The minimum inhibitory concentration (MIC) values were obtained using the modified microdilution method...
  74. ncbi Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Br J Dermatol 150:537-44. 2004
    ..Onychomycosis is a common nail disease that is often chronic, difficult to eradicate, and has a tendency to recur. The most common oral therapies for dermatophyte toenail onychomycosis include terbinafine, itraconazole and fluconazole...
  75. ncbi New treatments for tinea capitis
    Yuin Chew Chan
    National Skin Centre, 1 Mandalay Road, Singapore 308205
    Curr Opin Infect Dis 17:97-103. 2004
    ..The current standard of care for the treatment of tinea capitis in the USA is oral griseofulvin, but evidence is accumulating that some of the newer antifungal agents may also be useful.
  76. ncbi Presence of dermatophytes on the nails of tinea capitis patients. Prospective study in the area of Sfax (Tunisia)
    F Cheikhrouhou
    Laboratory of Parasitology Mycology, Sfax Faculty of Medicine, Sfax, Tunisia
    Mycoses 46:334-5. 2003
    ..Twenty-one cases of tinea were resistant to 6 weeks treatment with griseofulvin. Thirty per cent of them have had fungal elements in nails...
  77. ncbi Newer antifungal agents
    Michael Bigby
    J Am Acad Dermatol 49:357; author reply 357-8. 2003
  78. ncbi Terbinafine in fungal infections of the nails: a meta-analysis of randomized clinical trials
    M Haugh
    Centre Cochrane Français, Centre Léon Bérnard, 28 rue Laennec, 69373 Lyon Cedex 08, France
    Br J Dermatol 147:118-21. 2002
    ..Historically, there has been a general resistance to treating onychomycosis on the basis that such treatments were protracted and of uncertain outcome. However, modern treatments act more promptly and reliably...
  79. ncbi Ketoconazole and kids
    Rebecca McAllister
    Postgrad Med 112:12; author reply 12, 89. 2002
  80. ncbi Tinea capitis: no incision nor excision
    Laetitia von Laer Tschudin
    Department of Pediatric Surgery, University Hospital Center of the Canton of Vaud CHUV, 1011 Lausanne CHUV, Switzerland
    J Pediatr Surg 42:E33-6. 2007
    ....
  81. ncbi The assessment and management of tinea capitis in children
    Samina Ali
    Division of Pediatric Emergency Medicine, Department of Pediatrics, Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatr Emerg Care 23:662-5; quiz 666-8. 2007
    ..Oral griseofulvin remains the standard treatment agent, but terbinafine and itraconazole are also effective alternatives (..
  82. ncbi A study of dermatophytes and their in-vitro antifungal sensitivity
    M N Sumana
    Department of Microbiology, Govt Medical College, Mysore
    Indian J Pathol Microbiol 45:169-72. 2002
    ..One isolate each of Microsporum gypseum & Epidermophyton floccosum were obtained. Griseofulvin proved to be the best drug with a sensitivity of 94.4% followed by Miconazole (75% sensitive)...
  83. ncbi [Tinea capitis. Therapeutic options in the post-griseofulvin era]
    M Mohrenschlager
    Klinik und Poliklinik fur Dermatologie und Allergologie am Biederstein, Technische Universitat Munchen, Germany
    Hautarzt 53:788-94. 2002
    Tinea capitis is the most common dermatophyte infection during childhood. In Germany, only griseofulvin is approved for therapy by regulatory agencies...
  84. ncbi Guidelines for treatment of onychomycosis
    D T Roberts
    Southern General Hospital, Glasgow G51 4TF, UK
    Br J Dermatol 148:402-10. 2003
    ..They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiological aspects, diagnosis and investigation...
  85. pmc Diagnosis and management of scalp ringworm
    L C Fuller
    King s College Hospital, London SE5 9RS
    BMJ 326:539-41. 2003
  86. ncbi Tinea faciei: a report on four cases
    A Khaled
    Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia
    Acta Dermatovenerol Alp Pannonica Adriat 16:170-3. 2007
    ..Three patients recovered completely after one month of griseofulvin associated with topical terbinafine. Patient 3 was topically treated because she was pregnant...
  87. ncbi Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects
    H Vanden Bossche
    Steenweg op Gierle 68, B 2300 Turnhout, Belgium
    J Vet Pharmacol Ther 26:5-29. 2003
    ..This review includes chemical aspects, spectra of activity, mechanisms of action and resistance, adverse reactions and drug interactions of the antifungals in current use...
  88. ncbi The use of oral antifungal agents to treat onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:469-79, vi. 2003
    ..b>Griseofulvin was the first significant oral agent available to manage onychomycosis...
  89. ncbi The efficacy and safety of terbinafine in children
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:511-20. 2003
    ..These regimens still tend to be shorter than treatment with griseofulvin, and terbinafine may provide a higher compliance and a more cost-effective means of managing tinea capitis...
  90. ncbi An audit of the management of tinea capitis using the British Association of Dermatologists' guidelines
    V Madan
    Int J Dermatol 46:547. 2007
  91. ncbi [Onychomycosis]
    D Reinel
    Abteilung für Dermatologie, Venerologie und Allergologie, Bundeswehrkrankenhaus Hamburg, Hamburg
    Hautarzt 55:143-9. 2004
    ..Therefore onychomycosis is best treated by dermatologists...
  92. ncbi Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs
    Fernanda G Paião
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    FEMS Microbiol Lett 271:180-6. 2007
    ..to isolate transcripts specifically upregulated during Trichophyton rubrum exposure to acriflavin, fluconazole, griseofulvin, terbinafine or undecanoic acid...
  93. ncbi Treatment of tinea imbricata: a randomized clinical trial using griseofulvin, terbinafine, itraconazole and fluconazole
    A B Wingfield
    Department of Dermatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, U S A
    Br J Dermatol 150:119-26. 2004
    b>Griseofulvin has been the mainstay of treatment for tinea imbricata (TI) for decades; however, there have been few reports of efficacy of newer antifungals in the treatment of this condition...
  94. pmc Intracutaneous distributions of fluconazole, itraconazole, and griseofulvin in Guinea pigs and binding to human stratum corneum
    Satoshi Sobue
    Department of Clinical Pharmacology, Pfizer Global R and D, Tokyo Laboratories, Pfizer Japan Inc, Tokyo, Japan
    Antimicrob Agents Chemother 48:216-23. 2004
    We have compared the distribution of fluconazole (FLC) with that of itraconazole (ITC) and griseofulvin (GRF) in the abdominal skin tissues after a single oral dose was administered to guinea pigs...
  95. ncbi Tinea capitis due to Microsporum audouinii in Malta
    L Vella Zahra
    Medical School, Mycology Laboratory, Pathology Department, St Luke s Hospital, Malta
    Mycoses 46:433-5. 2003
    ..We describe a case of tinea capitis in a 4-year-old boy caused by Microsporum audouinii var. langeronii. This is the first recorded case of tinea capitis due to this dermatophyte in the Maltese Islands...
  96. ncbi [What is your diagnosis? Tinea capitis]
    R Boni
    White House, Center for Liposuction and Dermatology, Kraftstrasse 33 Mommsenstrasse 20, 8044 Zurich
    Praxis (Bern 1994) 92:1341-2. 2003
  97. ncbi Terbinafine. An update of its use in superficial mycoses
    K J McClellan
    Adis International Limited, Auckland, New Zealand
    Drugs 58:179-202. 1999
    ..The drug has shown greater efficacy than griseofulvin in dermatophyte onychomycosis, tinea pedis and tinea corporis/cruris, and comparable efficacy in children with ..
  98. ncbi Fungi recovered from Slovakian poultry feed mixtures and their toxinogenity
    Roman Labuda
    Microbiology Department, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr A Hlinku 2, 949 76 Nitra, Slovak Republic
    Ann Agric Environ Med 13:193-200. 2006
    ..mycotoxin producers, namely those forming aflatoxin B (1) (n=3), citrinin (17), cyclopiazonic acid (76), fumonisin B(1) (86), griseofulvin (42), moniliformin (18), ochratoxin A (5), patulin (56), penitrem A (30) and sterigmatocystin (10).
  99. ncbi The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria
    P V Tishler
    Brockton West Roxbury Veterans Affairs Medical Center and Harvard Medical School, Boston, Massachusetts 02132, USA
    Life Sci 65:207-14. 1999
    ..To test this, we studied the effects of drugs that precipitate acute attacks (lead, phenobarbital, griseofulvin, phenytoin, sulfanilamide, sulfisoxazole, 17alpha-ethinyl estradiol, 5beta-pregnan-3alpha-ol-20-one), drugs ..
  100. ncbi The significance of itraconazole for treatment of fungal infections of skin, nails and mucous membranes
    Hans Christian Korting
    Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
    J Dtsch Dermatol Ges 7:11-9, 11-20. 2009
    ..Itraconazole constitutes an important therapy option, along with fluconazole, terbinafine, ketoconazole and griseofulvin, for the treatment of dermatophyte infections of glabrous skin (tinea pedis, tinea manuum, tinea corporis and ..
  101. ncbi Solubility-excipient classification gradient maps
    Alex Avdeef
    pION INC, 5 Constitution Way Woburn, MA 01801, USA
    Pharm Res 24:530-45. 2007
    ..soluble drugs (four bases, two neutrals, and two acids): astemizole, butacaine, clotrimazole, dipyridamole, griseofulvin, progesterone, glibenclamide, and mefenemic acid...

Research Grants6

  1. Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati
    Lynne S Taylor; Fiscal Year: 2012
    ..Model drugs will include itraconazole and griseofulvin (combined with oral delivery polymers), dexamethasone and naltrexone (combined with biodegradable polymers), ..
  2. MECHANISM OF ACTION OF ANTITUMOR DRUGS
    Richard Luduena; Fiscal Year: 2000
    ..interactions with tubulin are colchicine, podophyllotoxin, curacin A, vinblastine, maytansine, phompsin, IK104, griseofulvin, BisANs, taxol, taxotere, GTP, and GDP...
  3. UNDERSTANDING THE DESIGN OF MOLECULAR MOTORS
    John Murray; Fiscal Year: 2000
    ..vincristine, vinblastine, and taxol, used for their anti-mitotic effects against a variety of neoplasms; griseofulvin, an anti-fungal agent; and others...
  4. Characterization of Candida albicans microtubules
    Leslie Wilson; Fiscal Year: 2003
    ..Finally, the mechanism of interaction of two known microtubule-targeted antifungal drugs (benomyl and griseofulvin) with the Candida tubulin will be determined and the mechanisms by which the drugs modulate the polymerization ..
  5. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..
  6. MECHANISM OF IL-12 INHIBITION BY CANDIDA ALBICANS
    Mahmoud Ghannoum; Fiscal Year: 2009
    ..Data obtained from these studies will lead to a better understanding of the complex immune response to CA infection and may identify novel prevention/treatment strategies for candidiasis. ..