indoleacetic acids

Summary

Summary: Acetic acid derivatives of the heterocyclic compound indole. (Merck Index, 11th ed)

Top Publications

  1. ncbi Local, efflux-dependent auxin gradients as a common module for plant organ formation
    Eva Benkova
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Cell 115:591-602. 2003
  2. ncbi A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
    Lionel Navarro
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Science 312:436-9. 2006
  3. ncbi Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis
    Jiri Friml
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Auf der Morgenstelle 3, 72076 Tubingen, Germany
    Nature 426:147-53. 2003
  4. ncbi The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
    Ikram Blilou
    Department of Molecular Genetics, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Nature 433:39-44. 2005
  5. ncbi The F-box protein TIR1 is an auxin receptor
    Nihal Dharmasiri
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Nature 435:441-5. 2005
  6. pmc Auxin: regulation, action, and interaction
    Andrew W Woodward
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Ann Bot 95:707-35. 2005
  7. ncbi An auxin-based degron system for the rapid depletion of proteins in nonplant cells
    Kohei Nishimura
    Department of Biological Sciences, Osaka University, Japan
    Nat Methods 6:917-22. 2009
  8. ncbi Auxin: a trigger for change in plant development
    Steffen Vanneste
    Department of Plant Systems Biology, VIB, Ghent University, Gent, Belgium
    Cell 136:1005-16. 2009
  9. ncbi Arabidopsis lateral root development: an emerging story
    Benjamin Peret
    Plant Sciences Division and Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Trends Plant Sci 14:399-408. 2009
  10. ncbi The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth
    Niko Geldner
    ZMBP, Entwicklungsgenetik, Universitat Tubingen, Auf der Morgenstelle 3, D 72076, Tubingen, Germany
    Cell 112:219-30. 2003

Detail Information

Publications282 found, 100 shown here

  1. ncbi Local, efflux-dependent auxin gradients as a common module for plant organ formation
    Eva Benkova
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Cell 115:591-602. 2003
    ..Our results suggest that PIN-dependent, local auxin gradients represent a common module for formation of all plant organs, regardless of their mature morphology or developmental origin...
  2. ncbi A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
    Lionel Navarro
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Science 312:436-9. 2006
    ..Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance...
  3. ncbi Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis
    Jiri Friml
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Auf der Morgenstelle 3, 72076 Tubingen, Germany
    Nature 426:147-53. 2003
    ..Our results indicate how the establishment of cell polarity, polar auxin efflux and local auxin response result in apical-basal axis formation of the embryo, and thus determine the axiality of the adult plant...
  4. ncbi The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
    Ikram Blilou
    Department of Molecular Genetics, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Nature 433:39-44. 2005
    ..Our data reveal an interaction network of auxin transport facilitators and root fate determinants that control patterning and growth of the root primordium...
  5. ncbi The F-box protein TIR1 is an auxin receptor
    Nihal Dharmasiri
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Nature 435:441-5. 2005
    ..Finally, TIR1 synthesized in insect cells binds Aux/IAA proteins in an auxin-dependent manner. Together, these results indicate that TIR1 is an auxin receptor that mediates Aux/IAA degradation and auxin-regulated transcription...
  6. pmc Auxin: regulation, action, and interaction
    Andrew W Woodward
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Ann Bot 95:707-35. 2005
    ..The phytohormone auxin is critical for plant growth and orchestrates many developmental processes...
  7. ncbi An auxin-based degron system for the rapid depletion of proteins in nonplant cells
    Kohei Nishimura
    Department of Biological Sciences, Osaka University, Japan
    Nat Methods 6:917-22. 2009
    ....
  8. ncbi Auxin: a trigger for change in plant development
    Steffen Vanneste
    Department of Plant Systems Biology, VIB, Ghent University, Gent, Belgium
    Cell 136:1005-16. 2009
    ..Thus, auxin appears to be a versatile trigger of preprogrammed developmental changes in plant cells...
  9. ncbi Arabidopsis lateral root development: an emerging story
    Benjamin Peret
    Plant Sciences Division and Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Trends Plant Sci 14:399-408. 2009
    ..We review how these studies have revealed that the plant hormone auxin represents a common signal that integrates these distinct yet interconnected developmental processes...
  10. ncbi The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth
    Niko Geldner
    ZMBP, Entwicklungsgenetik, Universitat Tubingen, Auf der Morgenstelle 3, D 72076, Tubingen, Germany
    Cell 112:219-30. 2003
    ..Our results demonstrate that GNOM is required for the recycling of auxin transport components and suggest that ARF-GEFs regulate specific endosomal trafficking pathways...
  11. ncbi Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins
    W M Gray
    The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA
    Nature 414:271-6. 2001
    ..Because domain II is conserved in nearly all AUX/IAA proteins in Arabidopsis, we propose that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects...
  12. ncbi Auxin-responsive gene expression: genes, promoters and regulatory factors
    Gretchen Hagen
    Department of Biochemistry, University of Missouri, Columbia 65211, USA
    Plant Mol Biol 49:373-85. 2002
    ..Auxin may regulate transcription on early response genes by influencing the types of interactions between ARFs and Aux/IAAs...
  13. ncbi Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
    N Geldner
    , , Auf der Morgenstelle 3, , Germany
    Nature 413:425-8. 2001
    ..In support of our conclusion, the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of auxin transport inhibitors...
  14. pmc Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development
    Q Xie
    Laboratory of Plant Cell Biology, Institute of Molecular Agrobiology, National University of Singapore, 117604 Singapore
    Genes Dev 14:3024-36. 2000
    ..Finally, TIR1-induced lateral root development is blocked by expression of antisense NAC1 cDNA, and NAC1 overexpression can restore lateral root formation in the auxin-response mutant tir1, indicating that NAC1 acts downstream of TIR1...
  15. ncbi Auxin response factors
    Tom J Guilfoyle
    University of Missouri, Department of Biochemistry, 117 Schweitzer Hall, Columbia, MI 65211, USA
    Curr Opin Plant Biol 10:453-60. 2007
    ..Recent advances have provided information on regulation of ARF gene expression, ARF roles in growth and developmental processes, and target genes regulated by ARFs...
  16. ncbi Defining auxin response contexts in plant development
    Martin Kieffer
    Centre for Plant Science, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Curr Opin Plant Biol 13:12-20. 2010
    ....
  17. ncbi AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis
    Jiri Friml
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Koln, Germany
    Cell 108:661-73. 2002
    ..We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning...
  18. ncbi PIN proteins perform a rate-limiting function in cellular auxin efflux
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Science 312:914-8. 2006
    ..This suggests a direct involvement of PINs in catalyzing cellular auxin efflux...
  19. ncbi Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis
    Peter Marhavy
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Gent, Belgium
    Dev Cell 21:796-804. 2011
    ....
  20. ncbi The interaction and integration of auxin signaling components
    Ken ichiro Hayashi
    Department of Biochemistry, Okayama University of Science, Okayama, 700 0005 Japan
    Plant Cell Physiol 53:965-75. 2012
    ..Systematic approaches using the comprehensive mapping of the expression and interaction of signaling modules and computational modeling would be valuable for integrating our knowledge of auxin signals and responses...
  21. pmc Auxin transport promotes Arabidopsis lateral root initiation
    I Casimiro
    Departmento de Ciencias Morfologicas y Biologia Celular y Animal, University of Extremadura, Badajoz, Spain
    Plant Cell 13:843-52. 2001
    ....
  22. ncbi The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche
    Mitsuhiro Aida
    Department of Molecular Cell Biology, Utrecht University, Padualaan 8, 3514CH Utrecht, The Netherlands
    Cell 119:109-20. 2004
    ..Thus, the PLT genes are key effectors for establishment of the stem cell niche during embryonic pattern formation...
  23. pmc Multilevel interactions between ethylene and auxin in Arabidopsis roots
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Plant Cell 19:2169-85. 2007
    ..This model not only implies existence of several levels of interaction but also provides a likely explanation for the strong ethylene response defects observed in auxin mutants...
  24. pmc Control of leaf vascular patterning by polar auxin transport
    Enrico Scarpella
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Genes Dev 20:1015-27. 2006
    ..We derive a model for self-regulated, reiterative patterning of all vein orders and postulate at its onset a common epidermal auxin-focusing mechanism for major-vein positioning and phyllotactic patterning...
  25. ncbi Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter
    Jozef Mravec
    Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Genetics, Ghent University, 9052 Gent, Belgium
    Nature 459:1136-40. 2009
    ....
  26. ncbi Polar PIN localization directs auxin flow in plants
    Justyna Wisniewska
    Center for Plant Molecular Biology ZMBP, Tubingen University, D 72076 Tubingen, Germany
    Science 312:883. 2006
    ..This finding provides a crucial piece in the puzzle of how auxin flow can be redirected via rapid changes in PIN polarity...
  27. pmc Auxin transporters--why so many?
    Eva Zazimalova
    Institute of Experimental Botany AS CR, Rozvojova 263, CZ 165 02 Prague 6, Czech Republic
    Cold Spring Harb Perspect Biol 2:a001552. 2010
    ....
  28. pmc Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice
    Xinhua Ding
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell 20:228-40. 2008
    ..Both enhanced resistance and abnormal development may be caused by inhibition of the expression of expansins via suppressed auxin signaling...
  29. pmc PIF4-mediated activation of YUCCA8 expression integrates temperature into the auxin pathway in regulating arabidopsis hypocotyl growth
    Jiaqiang Sun
    State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 8:e1002594. 2012
    ..These studies advance our understanding on the molecular mechanism underlying high temperature-induced adaptation in plant architecture...
  30. ncbi TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Cell 133:177-91. 2008
    ..Thus, the IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues...
  31. ncbi Auxin inhibits endocytosis and promotes its own efflux from cells
    Tomasz Paciorek
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Nature 435:1251-6. 2005
    ....
  32. pmc ABP1 mediates auxin inhibition of clathrin-dependent endocytosis in Arabidopsis
    Stephanie Robert
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Cell 143:111-21. 2010
    ....
  33. ncbi Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers
    Ananda K Sarkar
    Institute of Biology III, University of Freiburg, Schanzlestrasse 1, 79104 Freiburg, Germany
    Nature 446:811-4. 2007
    ..Importantly, both WOX5 and WUS maintain stem cells in either a root or shoot context. Together, our data indicate that stem cell maintenance signalling in both meristems employs related regulators...
  34. ncbi Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis
    Jiri Friml
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, 50829 Köln, Germany
    Nature 415:806-9. 2002
    ..In addition, actin-dependent relocalization of PIN3 in response to gravity provides a mechanism for redirecting auxin flux to trigger asymmetric growth...
  35. ncbi A genetic framework for the control of cell division and differentiation in the root meristem
    Raffaele Dello Ioio
    Dipartimento di Genetica e Biologia Molecolare, Laboratorio di Genomica e Proteomica Funzionale dei Sistemi Modello FGPL, Università La Sapienza Piazzale Aldo Moro 5, 00185 Rome, Italy
    Science 322:1380-4. 2008
    ....
  36. ncbi Auxin response factors ARF6 and ARF8 promote jasmonic acid production and flower maturation
    Punita Nagpal
    Department of Biology, University of North Carolina at Chapel Hill, CB 3280, Coker Hall, Chapel Hill, NC 27599 3280, USA
    Development 132:4107-18. 2005
    ....
  37. ncbi A novel sensor to map auxin response and distribution at high spatio-temporal resolution
    Géraldine Brunoud
    Laboratoire de Reproduction et Développement des Plantes, CNRS, INRA, ENS Lyon, UCBL, Universite de Lyon, 69364 Lyon, France
    Nature 482:103-6. 2012
    ..Our results illustrate the value of developing response input sensors such as DII-VENUS to provide high-resolution spatio-temporal information about hormone distribution and response during plant growth and development...
  38. ncbi Auxin transport routes in plant development
    Jan Petrasek
    Institute of Experimental Botany, ASCR, Prague 6, Czech Republic
    Development 136:2675-88. 2009
    ..This activity crucially contributes to the correct setting of developmental cues in embryogenesis, organogenesis, vascular tissue formation and directional growth in response to environmental stimuli...
  39. ncbi Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue
    L Gälweiler
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 282:2226-30. 1998
    ..AtPIN1 may act as a transmembrane component of the auxin efflux carrier...
  40. ncbi Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants
    Gabriel Krouk
    Biochimie et Physiologie Moleculaire des Plantes, UMR 5004 CNRS INRA SupAgro M UM2, Institut de Biologie Integrative des Plantes, Place Viala, 34060 Montpellier Cedex 1, France
    Dev Cell 18:927-37. 2010
    ..1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. This defines a mechanism connecting nutrient and hormone signaling during organ development...
  41. pmc The roles of auxin response factor domains in auxin-responsive transcription
    Shiv B Tiwari
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, Missouri 65211, USA
    Plant Cell 15:533-43. 2003
    ..The auxin response is mediated by the recruitment of Aux/IAA proteins to promoters that contain a DNA binding protein with a Q-rich MR and an attached CTD...
  42. pmc Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19
    Yoko Okushima
    Plant Gene Expression Center, Albany, California 94710, USA
    Plant Cell 17:444-63. 2005
    ..These observations provide molecular insight into the unique and overlapping functions of ARF gene family members in Arabidopsis...
  43. pmc MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes
    Allison C Mallory
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Plant Cell 17:1360-75. 2005
    ....
  44. ncbi Indole-3-acetic acid in microbial and microorganism-plant signaling
    Stijn Spaepen
    Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics, Heverlee, Belgium
    FEMS Microbiol Rev 31:425-48. 2007
    ..This review discusses past and recent data, and emerging views on IAA, a well-known phytohormone, as a microbial metabolic and signaling molecule...
  45. pmc Auxin biosynthesis by the YUCCA flavin monooxygenases controls the formation of floral organs and vascular tissues in Arabidopsis
    Youfa Cheng
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093 0116, USA
    Genes Dev 20:1790-9. 2006
    ....
  46. pmc The main auxin biosynthesis pathway in Arabidopsis
    Kiyoshi Mashiguchi
    Plant Science Center, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 108:18512-7. 2011
    ..Indole-3-acetaldehyde is probably not a precursor of IAA in the IPA pathway. Our results indicate that YUC proteins catalyze a rate-limiting step of the IPA pathway, which is the main IAA biosynthesis pathway in Arabidopsis...
  47. pmc The SAUR19 subfamily of SMALL AUXIN UP RNA genes promote cell expansion
    Angela K Spartz
    Department of Plant Biology, University of Minnesota, St Paul, MN 55108, USA
    Plant J 70:978-90. 2012
    ..Consistent with this possibility, SAUR19-24 proteins predominantly localize to the plasma membrane...
  48. ncbi ARF1, a transcription factor that binds to auxin response elements
    T Ulmasov
    Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Science 276:1865-8. 1997
    ..The carboxyl terminus of ARF1 contains two motifs found in the Aux/IAA class of proteins and appears to mediate protein-protein interactions...
  49. pmc Control of root cap formation by MicroRNA-targeted auxin response factors in Arabidopsis
    Jia wei Wang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, People s Republic of China
    Plant Cell 17:2204-16. 2005
    ..We further demonstrate that miR160-uncoupled production of ARF16 exerts pleiotropic effects on plant phenotypes, and miR160 plays an essential role in regulating Arabidopsis development and growth...
  50. pmc Conversion of tryptophan to indole-3-acetic acid by TRYPTOPHAN AMINOTRANSFERASES OF ARABIDOPSIS and YUCCAs in Arabidopsis
    Christina Won
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Proc Natl Acad Sci U S A 108:18518-23. 2011
    ..The yuc mutants accumulate IPA, and the taa mutants are partially IPA-deficient, indicating that TAAs are responsible for converting tryptophan to IPA, whereas YUCs play an important role in converting IPA to indole-3-acetic acid...
  51. pmc Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis
    Tongda Xu
    Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Cell 143:99-110. 2010
    ..These findings reveal Rho GTPase-based auxin-signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells...
  52. ncbi GH3-mediated auxin homeostasis links growth regulation with stress adaptation response in Arabidopsis
    Jung Eun Park
    Molecular Signaling Laboratory, Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 282:10036-46. 2007
    ..We therefore propose that GH3-mediated growth suppression directs reallocation of metabolic resources to resistance establishment and represents the fitness costs of induced resistance...
  53. ncbi Functional redundancy of PIN proteins is accompanied by auxin-dependent cross-regulation of PIN expression
    Anne Vieten
    Centre for Molecular Biology of Plants, University Tübingen, Auf der Morgenstelle 3, 72076 Tubingen, Germany
    Development 132:4521-31. 2005
    ..The compensatory properties of the PIN-dependent transport network might enable the stabilization of auxin gradients and potentially contribute to the robustness of plant adaptive development...
  54. pmc The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis
    John L Celenza
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Plant Physiol 137:253-62. 2005
    ..Together, this work implicates ATR1 as a key homeostatic regulator of Trp metabolism and suggests that ATR1 can be manipulated to coordinately control the suite of enzymes that synthesize IGs...
  55. pmc Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants
    Yi Tao
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 133:164-76. 2008
    ..This pathway is rapidly deployed to synthesize auxin at the high levels required to initiate the multiple changes in body plan associated with shade avoidance...
  56. pmc ABI4 mediates abscisic acid and cytokinin inhibition of lateral root formation by reducing polar auxin transport in Arabidopsis
    Doron Shkolnik-Inbar
    Department of Life Sciences and Doris and Bertie Black Center for Bioenergetics in Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel
    Plant Cell 22:3560-73. 2010
    ..We therefore suggest that ABI4 mediates ABA and cytokinin inhibition of LR formation via reduction of polar auxin transport and that the resulting decrease in root auxin leads to a reduction in LR development...
  57. pmc MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea
    Karim Sorefan
    Department of Biology, University of York, York, YO10 5YW, United Kingdom
    Genes Dev 17:1469-74. 2003
    ..A similar role has been proposed for the pea gene, RMS1. Accordingly, MAX4 and RMS1 were found to encode orthologous, auxin-inducible members of the polyene dioxygenase family...
  58. ncbi Auxin conjugates: their role for plant development and in the evolution of land plants
    Jutta Ludwig-Müller
    Institut fur Botanik, Technische Universitat Dresden, 01062 Dresden, Germany
    J Exp Bot 62:1757-73. 2011
    ..The implications for the regulation of auxin levels in different species will be discussed...
  59. ncbi Clathrin-mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis
    Pankaj Dhonukshe
    Center for Plant Molecular Biology ZMBP, Auf der Morgenstelle 3, University of Tubingen, D 72076 Tubingen, Germany
    Curr Biol 17:520-7. 2007
    ..Our data demonstrate that clathrin-dependent endocytosis is operational in plants and constitutes the predominant pathway for the internalization of numerous plasma-membrane-resident proteins including PIN auxin efflux carriers...
  60. pmc Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions
    Pankaj Dhonukshe
    Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
    Nature 456:962-6. 2008
    ..It also highlights the link between endocytosis-dependent polarity of individual cells and auxin distribution-dependent cell fate establishment for multicellular patterning...
  61. pmc Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation
    Jiaqiang Sun
    State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 21:1495-511. 2009
    ....
  62. ncbi TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis
    Heidi Szemenyei
    Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 319:1384-6. 2008
    ..These observations show that TPL is a transcriptional co-repressor and further our understanding of how auxin regulates transcription during plant development...
  63. ncbi Competitive canalization of PIN-dependent auxin flow from axillary buds controls pea bud outgrowth
    Jozef Balla
    Department of Plant Biology, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic
    Plant J 65:571-7. 2011
    ..These results support a model in which the apical and lateral auxin sources compete for primary channels of auxin transport in the stem to control the outgrowth of axillary buds...
  64. ncbi Lateral root formation is blocked by a gain-of-function mutation in the SOLITARY-ROOT/IAA14 gene of Arabidopsis
    Hidehiro Fukaki
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Plant J 29:153-68. 2002
    ..These observations indicate that SLR/IAA14 is a key regulator in auxin-regulated growth and development, particularly in lateral root formation...
  65. ncbi Nitrate and phosphate availability and distribution have different effects on root system architecture of Arabidopsis
    Birgit I Linkohr
    Department of Biology, University of York, UK
    Plant J 29:751-60. 2002
    ..The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response...
  66. ncbi Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling
    Brandon Moore
    Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 300:332-6. 2003
    ..Plants use HXK as a glucose sensor to interrelate nutrient, light, and hormone signaling networks for controlling growth and development in response to the changing environment...
  67. ncbi Evaluating auxin distribution in tomato (Solanum lycopersicum) through an analysis of the PIN and AUX/LAX gene families
    Richard J Pattison
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Plant J 70:585-98. 2012
    ....
  68. ncbi A regulated auxin minimum is required for seed dispersal in Arabidopsis
    Karim Sorefan
    Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, Norfolk NR4 7UH, UK
    Nature 459:583-6. 2009
    ..We propose that the simplicity of formation and maintenance make local hormone minima particularly well suited to specify a small number of cells such as the stripes at the valve margins...
  69. pmc Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid
    Paul E Staswick
    Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68583, USA
    Plant Cell 17:616-27. 2005
    ..This evidence establishes that several GH3 genes encode IAA-amido synthetases, which help to maintain auxin homeostasis by conjugating excess IAA to amino acids...
  70. ncbi Plant development is regulated by a family of auxin receptor F box proteins
    Nihal Dharmasiri
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Dev Cell 9:109-19. 2005
    ..Correspondingly, all TIR1/AFB proteins interact with BDL, and BDL is stabilized in triple mutant plants. Our results indicate that TIR1 and the AFB proteins collectively mediate auxin responses throughout plant development...
  71. ncbi Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF
    T Steinmann
    Entwicklungsgenetik, Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Auf der Morgenstelle 1, D 72076 Tubingen, Germany
    Science 286:316-8. 1999
    ..GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport...
  72. ncbi Auxin receptors and plant development: a new signaling paradigm
    Keithanne Mockaitis
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Cell Dev Biol 24:55-80. 2008
    ..Moreover, auxin receptor function is the first example of small-molecule regulation of an SCF ubiquitin ligase and may have important implications for studies of regulated protein degradation in other species, including animals...
  73. pmc The march of the PINs: developmental plasticity by dynamic polar targeting in plant cells
    Wim Grunewald
    Department of Plant Systems Biology, VIB, Technologiepark, Gent, Belgium
    EMBO J 29:2700-14. 2010
    ..Also, the entry points for different signals and regulations including by auxin itself will be discussed within the context of morphological and developmental consequences of polar targeting and subcellular trafficking...
  74. ncbi Expression of cytokinin biosynthetic isopentenyltransferase genes in Arabidopsis: tissue specificity and regulation by auxin, cytokinin, and nitrate
    Kaori Miyawaki
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Plant J 37:128-38. 2004
    ..They were expressed ubiquitously, with highest expression in proliferating tissues. These findings are discussed in relation to the role of cytokinins in plant development...
  75. ncbi Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages
    Po Pu Liu
    Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA
    Plant J 52:133-46. 2007
    ....
  76. pmc Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds
    José Antonio Aguilar-Martínez
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Plant Cell 19:458-72. 2007
    ..The conservation of BRC1/tb1 function among distantly related angiosperm species suggests that a single ancestral mechanism of branching control integration evolved before the radiation of flowering plants...
  77. ncbi A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux
    Jiri Friml
    Developmental Genetics, Center for Molecular Biology of Plants, University Tübingen, Auf der Morgenstelle 3, D 72076 Tubingen, Germany
    Science 306:862-5. 2004
    ..Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes...
  78. pmc Gibberellins regulate lateral root formation in Populus through interactions with auxin and other hormones
    Jiqing Gou
    School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, Michigan 49931 1295, USA
    Plant Cell 22:623-39. 2010
    ..These results suggest a mechanism for GA-regulated modulation of lateral root proliferation associated with regulation of plant allometry during the stress response...
  79. pmc Cellular responses to auxin: division versus expansion
    Catherine Perrot-Rechenmann
    Institut des Sciences du Vegetal, UPR2355 CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, Cedex, France
    Cold Spring Harb Perspect Biol 2:a001446. 2010
    ..In addition, it offers the necessary flexibility for generating differential responses within a given cell depending on its developmental context...
  80. ncbi AUXIN BINDING PROTEIN 1: functional and evolutionary aspects
    Alexandre Tromas
    Institut des Sciences du Vegetal, CNRS UPR2355, University of Paris Sud, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Trends Plant Sci 15:436-46. 2010
    ..An evaluation of the evidence for ABP1 function according to its cellular localization supports the plasma membrane as a starting point for ABP1-mediated auxin signaling...
  81. pmc AUXIN RESPONSE FACTOR8 regulates Arabidopsis petal growth by interacting with the bHLH transcription factor BIGPETALp
    Emilie Varaud
    Reproduction et Developpement des Plantes, Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Universite Lyon 1, Ecole Normale Superieure, 69364 Lyon Cedex, France
    Plant Cell 23:973-83. 2011
    ..The data provide evidence of an interaction between an ARF and a bHLH transcription factor and of its biological significance in regulating petal growth, with local auxin levels likely influencing such a biological function...
  82. pmc miR393 and secondary siRNAs regulate expression of the TIR1/AFB2 auxin receptor clade and auxin-related development of Arabidopsis leaves
    Azeddine Si-Ammour
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, 4058 Basel, Switzerland
    Plant Physiol 157:683-91. 2011
    ..Thus, miR393 and possibly siTAARs regulate auxin perception and certain auxin-related aspects of leaf development...
  83. pmc Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis
    D E Brown
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Plant Physiol 126:524-35. 2001
    ..These results are consistent with a role for flavonoids as endogenous regulators of auxin transport...
  84. ncbi Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux
    Marta Michniewicz
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Tubingen, Germany
    Cell 130:1044-56. 2007
    ..In the case of PIN proteins, this mechanism enables switches in the direction of intercellular auxin fluxes, which mediate differential growth, tissue patterning, and organogenesis...
  85. pmc Differential auxin-transporting activities of PIN-FORMED proteins in Arabidopsis root hair cells
    Anindya Ganguly
    Department of Biological Sciences and Genomics and Breeding Institute, Seoul National University, Seoul 151 742, Korea
    Plant Physiol 153:1046-61. 2010
    ..These results suggest that different PINs behave differentially in catalyzing auxin transport depending upon their molecular activity and subcellular localization in the root hair cell...
  86. pmc ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis
    Shingo Nagawa
    Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, California, United States of America
    PLoS Biol 10:e1001299. 2012
    ....
  87. pmc Auxin biosynthesis and its role in plant development
    Yunde Zhao
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093 0116, USA
    Annu Rev Plant Biol 61:49-64. 2010
    ..In this review, I summarize the recent advances in dissecting auxin biosynthetic pathways and how the understanding of auxin biosynthesis provides a crucial angle for analyzing the mechanisms of plant development...
  88. ncbi The ABC of auxin transport: the role of p-glycoproteins in plant development
    Markus Geisler
    Zurich Basel Plant Science Center, Institute of Plant Biology, University of Zurich, CH 8007 Zurich, Switzerland
    FEBS Lett 580:1094-102. 2006
    ..Current models on the physiological role of PGPs, their functional interaction and their involvement in cell-to cell (polar) auxin transport are discussed...
  89. pmc miR390, Arabidopsis TAS3 tasiRNAs, and their AUXIN RESPONSE FACTOR targets define an autoregulatory network quantitatively regulating lateral root growth
    Elena Marin
    Laboratoire de Biologie du Développement des Plantes, Commissariat à l Energie Atomique Cadarache, Centre National de la Recherche Scientifique, Universite Aix Marseille, 13108 St Paul lez Durance, France
    Plant Cell 22:1104-17. 2010
    ..These results also show how small regulatory RNAs integrate with auxin signaling to quantitatively regulate organ growth during development...
  90. ncbi A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants
    Elke Barbez
    Department of Plant Systems Biology, Ghent University, 9052 Gent, Belgium
    Nature 485:119-22. 2012
    ....
  91. ncbi The Solanum lycopersicum auxin response factor 7 (SlARF7) regulates auxin signaling during tomato fruit set and development
    Maaike de Jong
    Department of Plant Cell Biology, Institute for Water and Wetland Research, Radboud University Nijmegen, Heyendaalseweg 135, Nijmegen, The Netherlands
    Plant J 57:160-70. 2009
    ....
  92. pmc Functional genomic analysis of the AUXIN/INDOLE-3-ACETIC ACID gene family members in Arabidopsis thaliana
    Paul J Overvoorde
    Plant Gene Expression Center, Albany, California 94710, USA
    Plant Cell 17:3282-300. 2005
    ..The data suggest extensive functional redundancy among Aux/IAA gene family members and that enhanced stability of the AXR3/IAA17 protein severely alters the molecular phenotype, resulting in developmental defects...
  93. pmc Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis
    Bruno Muller
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 453:1094-7. 2008
    ..These results provide a molecular model of transient and antagonistic interaction between auxin and cytokinin critical for specifying the first root stem-cell niche...
  94. pmc Phosphate availability alters lateral root development in Arabidopsis by modulating auxin sensitivity via a mechanism involving the TIR1 auxin receptor
    Claudia Anahí Pérez-Torres
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, 36821 Irapuato, Guanajuato, Mexico
    Plant Cell 20:3258-72. 2008
    ....
  95. pmc A role for auxin redistribution in the responses of the root system architecture to phosphate starvation in Arabidopsis
    Philippe Nacry
    Laboratoire de Biochimie and Physiologie Moléculaire des Plantes, Unité Mixte de Recherche 5004, Institut National de la Recherche Agronomique, Universite Montpellier 2, F 34060 Montpellier Cedex 1, France
    Plant Physiol 138:2061-74. 2005
    ....
  96. ncbi Local auxin production: a small contribution to a big field
    John W Chandler
    Department of Developmental Biology, University of Cologne, Gyrhofstrasse 17, Cologne, Germany
    Bioessays 31:60-70. 2009
    ..Many alternative and redundant pathways of auxin synthesis exist in many plants and it is emerging that they may function in response to environmental cues...
  97. ncbi Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism
    M J Bennett
    Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Science 273:948-50. 1996
    ..The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature...
  98. pmc ARF7 and ARF19 regulate lateral root formation via direct activation of LBD/ASL genes in Arabidopsis
    Yoko Okushima
    Nara Institute of Science and Technology, Graduate School of Biological Sciences, Takayama 8916 5, Ikoma, Nara 630 0101, Japan
    Plant Cell 19:118-30. 2007
    ..Our results reveal that ARFs regulate lateral root formation via direct activation of LBD/ASLs in Arabidopsis...
  99. pmc Complex regulation of the TIR1/AFB family of auxin receptors
    G Parry
    Department of Biology, Indiana University, Bloomington, IN 47401, USA
    Proc Natl Acad Sci U S A 106:22540-5. 2009
    ..However our data suggest that this regulation is complex. Our results suggest that differences between members of the auxin receptor family may contribute to the complexity of auxin response...
  100. ncbi A role for flavin monooxygenase-like enzymes in auxin biosynthesis
    Y Zhao
    Howard Hughes Medical Institute, Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 291:306-9. 2001
    ..Results from tryptophan analog feeding experiments and biochemical assays indicate that YUCCA catalyzes hydroxylation of the amino group of tryptamine, a rate-limiting step in tryptophan-dependent auxin biosynthesis...
  101. pmc Root system architecture from coupling cell shape to auxin transport
    Marta Laskowski
    Department of Biology, Oberlin College, Oberlin, Ohio, USA
    PLoS Biol 6:e307. 2008
    ..Thus, lateral root patterning combines a trigger, such as cell size difference due to bending, with a self-organizing system that mediates alterations in auxin transport...

Research Grants17

  1. Interaction of auxin and abscisic acid signaling
    LUCIA STRADER; Fiscal Year: 2007
    ..By studying and cloning suppresors, as well as identifying IBR5 substrates, a more in-depth understanding of auxin and ABA cross-talk will be gained. ..
  2. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  3. BIOLOGICAL STUDIES OF PIPERIDINE ANALOGS OF COCAINE
    Alan Kozikowski; Fiscal Year: 2001
    ..4. For compounds meeting set criteria, to further evaluate their behavioral pharmacological profile in animals using intravenous drug self-administration and drug discrimination procedures. ..
  4. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..abstract_text> ..
  5. Chemistry and Biology of 5-HT2C Receptor Ligands for Drug Abuse
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
    ....
  6. SHY2/IAA3 in auxin regulation of plant development
    Jason Reed; Fiscal Year: 2006
    ..These experiments will help us understand how auxin regulates development in a model system, and will in the future allow manipulation of morphology of crop plants in ways beneficial to human health. ..
  7. PAI-1 and The Vascular Toxicity of Aldosterone
    Nancy Brown; Fiscal Year: 2005
    ..This multi-disciplinary approach will generate new information regarding the role of aldosterone in vascular toxicity and, thus, improve our ability to prevent and treat cardiovascular disease. ..
  8. CHEMICAL AND PHARMACOLOGICAL STUDIES OF COCAINE ANALOGS
    Alan Kozikowski; Fiscal Year: 2004
    ....
  9. Activation of Maternal mRNA in Early Development
    Keith Hutchison; Fiscal Year: 2004
    ..In addition, we will exam the role of a novel form of a major translation control protein, elF4E, in this process. ..
  10. DESIGN OF LIGANDS SELECTIVE FOR THE DAG SUPERFAMILY
    Alan Kozikowski; Fiscal Year: 2002
    ..To assess the effect of alterations in the ligand's hydrophobic side chain on its tumor promoting activity, studies of skin hyperplasia will be conducted. ..
  11. Chemistry and Pharmacology of a New Nicotine Ligands
    Alan Kozikowski; Fiscal Year: 2007
    ..Functional activity will be evaluated using established 86RbC1 efflux assays and/or whole cell patch clamp measurements. ..
  12. Mechanisms of Cardiac Regeneration
    DINENDER SINGLA; Fiscal Year: 2008
    ..The results from the proposed projects will have long-term implications for future cell-based therapy to treat heart disease (s) using embryonic stem cells or potentially other donor cells. [unreadable] [unreadable] [unreadable]..
  13. FUNCTIONAL ANALYSIS OF MAIZE GROUP-1 POLLEN ALLERGENS
    Daniel Cosgrove; Fiscal Year: 2004
    ..Finally, we will leverage the insights gained from analysis of Zea ml to study the function of group-Il and group-Ill grass pollen allergens, which show significant sequence similarity with the carboxy terminus of group-I allergens. ..
  14. PKC Modulators for the Treatment of Alzheimer's disease
    Alan Kozikowski; Fiscal Year: 2008
    ..For the best compounds from Aim 2, perform studies in triple transgenic mice to ascertain effects on Abeta and sAPPalpha levels and plaque formation in vivo. ..
  15. Chromatin remodeling in Arabidopsis development
    Jennifer Pfluger; Fiscal Year: 2007
    ..Thus, Arabidopsis is an advantageous model system to enable the study of ATP-dependent chromatin remodeling complexes throughout development. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Vanderbilt Mentored Clinical Research Scholar Program
    Nancy Brown; Fiscal Year: 2006
    ..The VCRS program will train successful new clinical investigators who will serve as leaders role in the post-genomic era. [unreadable] [unreadable] [unreadable]..