isonicotinic acids

Summary

Summary: Heterocyclic acids that are derivatives of 4-pyridinecarboxylic acid (isonicotinic acid).

Top Publications

  1. pmc A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
    Collin J Lobb
    Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurophysiol 104:403-13. 2010
  2. pmc Acquired resistance in Arabidopsis
    S Uknes
    Agricultural Biotechnology Research Unit, CIBA GEIGY Corporation, Research Triangle Park, North Carolina 27709
    Plant Cell 4:645-56. 1992
  3. pmc Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells
    Abdallah Hayar
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 98:1052-6. 2007
  4. ncbi The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat
    Mathias Dutschmann
    Department of Neuro and Sensory Physiology, Georg August University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Eur J Neurosci 24:1071-84. 2006
  5. ncbi Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings
    Roman Tyzio
    INMED INSERM U29, 163, Marseille, France
    Epilepsia 48:96-105. 2007
  6. ncbi GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: a patch-clamp and single cell RT-PCR study
    C W Alsbo
    Laboratory of Neuropathology, University of Copenhagen, 11, Frederik V vej, DK-2100, Copenhagen, Denmark
    Eur J Neurosci 13:1673-82. 2001
  7. pmc Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions
    S L Hansen
    Department of Pharmacology, Royal Danish School of Pharmacy, 2 Universitetsparken, 2100 Copenhagen, Denmark
    Br J Pharmacol 133:539-49. 2001
  8. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
  9. ncbi GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways
    H J Reis
    Department of Physiology and Cell Biology 352, University of Nevada, School of Medicine, 1660 North Virginia Street, Reno, NV 89557 0046, USA
    Neuroscience 139:485-94. 2006
  10. pmc Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA
    Christof Geigerseder
    Anatomisches Institut der Ludwig Maximilians Universität München, Biedersteinerstr, 29, D 80802 München, Germany
    Reprod Biol Endocrinol 2:13. 2004

Research Grants

Detail Information

Publications187 found, 100 shown here

  1. pmc A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
    Collin J Lobb
    Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurophysiol 104:403-13. 2010
    ..These results support a bidirectional mechanism by which GABAergic inputs, in balance with NMDA receptor-mediated excitatory inputs, control the firing pattern of dopaminergic neurons...
  2. pmc Acquired resistance in Arabidopsis
    S Uknes
    Agricultural Biotechnology Research Unit, CIBA GEIGY Corporation, Research Triangle Park, North Carolina 27709
    Plant Cell 4:645-56. 1992
    ..Arabidopsis should serve as a genetic model for studies of this type of immune response in plants...
  3. pmc Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells
    Abdallah Hayar
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 98:1052-6. 2007
    ..We suggest that ET cell excitatory and inhibitory inputs may be encoded as a change in the pattern of spike bursting in ET cells, which together with mitral/tufted cells constitute the output circuit of the olfactory bulb...
  4. ncbi The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat
    Mathias Dutschmann
    Department of Neuro and Sensory Physiology, Georg August University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Eur J Neurosci 24:1071-84. 2006
    ....
  5. ncbi Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings
    Roman Tyzio
    INMED INSERM U29, 163, Marseille, France
    Epilepsia 48:96-105. 2007
    ..We propose that excitatory GABA contributes to enhanced excitability and ictogenesis in the neonatal rat hippocampus...
  6. ncbi GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: a patch-clamp and single cell RT-PCR study
    C W Alsbo
    Laboratory of Neuropathology, University of Copenhagen, 11, Frederik V vej, DK-2100, Copenhagen, Denmark
    Eur J Neurosci 13:1673-82. 2001
    ..The present study offers a method to identify subunit interactions in heteromeric receptor complexes...
  7. pmc Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions
    S L Hansen
    Department of Pharmacology, Royal Danish School of Pharmacy, 2 Universitetsparken, 2100 Copenhagen, Denmark
    Br J Pharmacol 133:539-49. 2001
    ..Moreover, this study shows that pharmacological actions determined in oocytes are generally in agreement with data obtained from cultured neurons...
  8. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
    ....
  9. ncbi GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways
    H J Reis
    Department of Physiology and Cell Biology 352, University of Nevada, School of Medicine, 1660 North Virginia Street, Reno, NV 89557 0046, USA
    Neuroscience 139:485-94. 2006
    ..A concentration of 5 microM GABA, although frequently used in pharmacological experiments, seems to cause a detrimental response reminiscent of the neurotoxic effects glutamate has in the CNS...
  10. pmc Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA
    Christof Geigerseder
    Anatomisches Institut der Ludwig Maximilians Universität München, Biedersteinerstr, 29, D 80802 München, Germany
    Reprod Biol Endocrinol 2:13. 2004
    ..Thus testicular GABA may play an as yet unrecognized role in the development of Leydig cells during the differentiation of the testicular interstitial compartment...
  11. ncbi Neurokininergic mechanism within the lateral crescent nucleus of the parabrachial complex participates in the heart-rate response to nociception
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:1412-20. 2005
    ....
  12. ncbi A modeling study suggests complementary roles for GABAA and NMDA receptors and the SK channel in regulating the firing pattern in midbrain dopamine neurons
    Alexander O Komendantov
    Center for Computational Science, Tulane University, New Orleans 70118, USA
    J Neurophysiol 91:346-57. 2004
    ..Another prediction of the model is that blocking the SK channel current in vivo will facilitate bursting, but not as robustly as blocking the GABAA receptors...
  13. ncbi GABA(A) receptor ligands and their therapeutic potentials
    Bente Frølund
    Departments of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, DK 2100, Denmark
    Curr Top Med Chem 2:817-32. 2002
    ....
  14. ncbi Chloroisonicotinamide derivative induces a broad range of disease resistance in rice and tobacco
    Hideo Nakashita
    Microbial Toxicology Laboratory, RIKEN Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Plant Cell Physiol 43:823-31. 2002
    ..The fact that all of these chemicals are effective in rice and tobacco suggests that several common components function in disease resistance in both plant species...
  15. ncbi Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes
    Laurence Desrues
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, 76821 Mont Saint Aignan, France
    Peptides 29:727-34. 2008
    ..These data suggest that functional interaction between UT and GABA(A)R negatively regulates coupling of UT to the classical PLC/IP(3) signaling cascade as well as to the adenylyl cyclase/PKA pathway...
  16. ncbi Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells
    Daniel Ulrich
    Institute of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Eur J Neurosci 18:2159-65. 2003
    ..I conclude that shunting inhibition in pyramidal cells has a dual impact on neural output: it is divisive for subthreshold voltages but subtractive for spike frequencies...
  17. ncbi Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro
    Dmytro Isaev
    Section of Neurology, Dartmouth Medical School, Dartmouth Hitchcock Medical School, Lebanon, NH 03756, USA
    J Neurophysiol 94:2987-92. 2005
    ..Thus in the model of high-K(+)/low Mg(2+)-induced seizures both in in vivo and in vitro conditions, GABA, acting via GABA(A) receptors, has an anticonvulsant effect during the critical developmental period of enhanced excitability...
  18. ncbi Priming in plant-pathogen interactions
    Uwe Conrath
    Plant Physiology, Dept Biology, University of Kaiserslautern, PO Box 3049, 67653, Kaiserslautern, Germany
    Trends Plant Sci 7:210-6. 2002
    ..These studies show that priming often depends on the induced disease resistance key regulator NPR1 (also known as NIM1 or SAI1) and that priming has a major effect on the regulation of cellular plant defence responses...
  19. pmc Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii
    Anthony E Pickering
    Sir Humphry Davy Department of Anaesthesia, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Physiol 551:589-99. 2003
    ..Further, these findings confirm that baroreflex sympathetic and parasympathetic pathways diverge, and can be independently controlled, within the NTS...
  20. ncbi Respiratory rhythm entrainment by somatic afferent stimulation
    Jeffrey T Potts
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 25:1965-78. 2005
    ....
  21. ncbi Over-expression of TGA5, which encodes a bZIP transcription factor that interacts with NIM1/NPR1, confers SAR-independent resistance in Arabidopsis thaliana to Peronospora parasitica
    Han Suk Kim
    Cornell University, Department of Plant Pathology, 360 Plant Science Bldg, Ithaca, NY 14853, USA
    Plant J 32:151-63. 2002
    ..Resistance was retained when a TGA5-accumulating line was combined genetically with a nim1-1 mutation or nahG (salicylate hydroxylase) transgene, indicating that resistance in these plants is due to an SA and SAR-independent mechanism...
  22. ncbi Antioxidant activity of new ruthenium compounds
    Marcos Marques da Silva Paula
    Laboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense UNESC, Criciuma, SC, Brazil
    Redox Rep 10:139-43. 2005
    ..Higher doses (above 200 microM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1-10 microM)...
  23. ncbi The relationship between chemical structure and antimicrobial activity of selected nicotinates, p-iodobenzoates, picolinates and isonicotinates
    P Koczoń
    Department of Chemistry, Warsaw Agricultural University, ul Nowoursynowska 161C, 02728 Warsaw, Poland
    Spectrochim Acta A Mol Biomol Spectrosc 61:1917-22. 2005
    ..The relationship between electronic properties estimated by vibrational spectroscopy and antimicrobial activity of studied complexes was investigated...
  24. ncbi Separation of nicotinic acid and its structural isomers using 1-ethyl-3-methylimidazolium ionic liquid as a buffer additive by capillary electrophoresis
    Michał Piotr Marszałł
    Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, ul Gen J Hallera 107, 80 416 Gdansk, Poland
    J Pharm Biomed Anal 41:329-32. 2006
    ..At this ionic liquid concentration in a BGE resolution factor between nicotinic and isonicotinic acids increased to 1.86...
  25. ncbi IR-SERS study and theoretical analogue on the adsorption behavior of pyridine carboxylic acid on silver nanoparticles
    Li Ran Wang
    Beijing Key Lab of Nano Photonics and Nano Structure, NPNS, Department of Physics, Capital Normal University, Beijing, 100037, China
    Spectrochim Acta A Mol Biomol Spectrosc 63:614-8. 2006
    ....
  26. ncbi Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors
    Aparecido Ribeiro de Souza
    Instituto de Quimica, Universidade Federal de Goias, Campus Samambaia, CP 131, 74001 970 Goiania, GO, Brazil
    Eur J Med Chem 41:1214-6. 2006
    ....
  27. ncbi Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
    Robert Raja
    School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK
    Chemistry 14:2340-8. 2008
    ....
  28. ncbi Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds
    Keiko Iwata
    Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
    Biosci Biotechnol Biochem 67:1132-5. 2003
    ..The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use...
  29. ncbi Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors
    Shanthaveerappa K Boovanahalli
    Molecular Cancer Research Center, KRIBB, Daejeon 305 806, Republic of Korea
    Bioorg Med Chem Lett 17:6305-10. 2007
    ..In particular, analogue 17 displayed potent inhibition of hypoxia-induced accumulation of HIF-1alpha protein in Hep3B cell line, in addition to the dose-dependent inhibition of HIF-1 target genes VEGF and EPO...
  30. ncbi The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid
    J M Manners
    F A Janssens Laboratory of Genetics, Katholieke Universiteit Leuven, Heverlee Leuven, Belgium
    Plant Mol Biol 38:1071-80. 1998
    ..The transgenic plants containing the PDF1.2-based promoter-reporter construct will provide useful tools for future genetic dissection of this novel systemic signalling pathway...
  31. ncbi A cluster of five cell wall-associated receptor kinase genes, Wak1-5, are expressed in specific organs of Arabidopsis
    Z H He
    Botany Department, Duke University, Durham, NC 27708, USA
    Plant Mol Biol 39:1189-96. 1999
    ....
  32. ncbi N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists
    George A Doherty
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 13:1891-5. 2003
    ..These compounds exhibit subnanomolar binding affinity to VLA-4 and significant off-rates. The interplay between off-rate, protein binding and pharmacokinetics is discussed...
  33. ncbi Modulation of creatine kinase activity by ruthenium complexes
    Francine Zanette
    Laboratório de Fisiopatologia Experimental, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    J Inorg Biochem 101:267-73. 2007
    ..Further research is necessary in order to elucidate the effects of ruthenium complexes in other important metabolic enzymes...
  34. ncbi Pathogen stress increases somatic recombination frequency in Arabidopsis
    Jan M Lucht
    Friedrich Miescher Institute, PO Box 2543, CH 4002 Basel, Switzerland
    Nat Genet 30:311-4. 2002
    ..The increased genetic flexibility might facilitate evolutionary adaptation of plant populations to stressful environments...
  35. ncbi Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide--potential radiotracers for tuberculosis
    C W Somawardhana
    Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Int J Rad Appl Instrum A 42:215-20. 1991
    ..This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs glioma), and CNS tuberculosis in immunosuppressed subjects...
  36. pmc Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways
    Michael Dalgaard Mikkelsen
    Plant Biochemistry Laboratory, Department of Plant Biology, The Royal Veterinary and Agricultural University, Thorvaldsensvej 40, opgang 10, St, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Plant Physiol 131:298-308. 2003
    ..Thus, different defense pathways activate subsets of biosynthetic enzymes, leading to the accumulation of specific glucosinolates...
  37. ncbi Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water
    Yiguang Jin
    Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, People s Republic of China
    Colloids Surf B Biointerfaces 64:229-35. 2008
    ..The self-assembled nanostructures may likely be the potential self-assembled drug delivery systems for tuberculosis therapy...
  38. ncbi Catalase-peroxidases (KatG) exhibit NADH oxidase activity
    Rahul Singh
    Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    J Biol Chem 279:43098-106. 2004
    ..Isonicotinoyl-NAD synthesis from a mixture of NAD+ and INH is KatG-dependent and is activated by manganese ion. M. tuberculosis KatG catalyzes isonicotinoyl-NAD formation from NAD+ and INH more efficiently than B. pseudomallei KatG...
  39. ncbi Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation
    J A Marcinkeviciene
    Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    J Biol Chem 270:22290-5. 1995
    ..The role of mycobacterial catalase-peroxidases in the oxidative activation of the antitubercular prodrug isoniazid is discussed...
  40. ncbi Langerhans cells release prostaglandin D2 in response to nicotinic acid
    Dominique Maciejewski-Lenoir
    Arena Pharmaceuticals Inc, San Diego, California 92121, USA
    J Invest Dermatol 126:2637-46. 2006
    ..These results suggest that nicotinic acid mediates its flushing side effect by interacting with GPR109A on skin Langerhans cells, resulting in release of PGD(2)...
  41. ncbi Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
    Hacer Bayrak
    Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey
    Eur J Med Chem 44:4362-6. 2009
    ..All newly synthesized compounds were screened for their antimicrobial activity. The antimicrobial activity study revealed that all the compounds screened showed good or moderate activity except compounds 2, 7a, 7b, 8 and 9b...
  42. ncbi Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae)
    E N Bum
    Departement des Sciences Biologiques, Faculte des Sciences, Université de Ngaoundéré, B P 454, Ngaoundere, Cameroon
    J Ethnopharmacol 76:145-50. 2001
    ..With these effects, the rhizome of C. articulatus L. possesses anticonvulsant properties in animals that might explain its use as a traditional medicine for epilepsy in Africa...
  43. ncbi A regenerable ruthenium tetraammine nitrosyl complex immobilized on a modified silica gel surface: preparation and studies of nitric oxide release and nitrite-to-NO conversion
    Fabio Gorzoni Doro
    Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av dos Bandeirantes 3900, 14040 901 Ribeirao Preto, SP, Brazil
    J Colloid Interface Sci 307:405-17. 2007
    ..Regeneration was done by reaction with nitrite in aqueous solution (pH 7.4). Reduction-regeneration cycles were performed up to three times with no significant leaching of the ruthenium complex...
  44. ncbi LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method
    Hemant Bhutani
    Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160062, Punjab, India
    J Pharm Biomed Anal 43:1213-20. 2007
    ..The same was indicated to be responsible for discolouration of isoniazid bulk drug substance and formulations, which is a familiar problem. The mechanism of formation of the said compound is outlined...
  45. ncbi Translational activation of ethanol-inducible cytochrome P450 (CYP2E1) by isoniazid
    K S Park
    Laboratory of Metabolism and Molecular Biology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852
    Eur J Pharmacol 248:7-14. 1993
    ....
  46. ncbi Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci
    Matthias Broekema
    Bristol Myers Squibb Medical Imaging, North Billerica, Massachusetts 01862, USA
    J Med Chem 48:6442-53. 2005
    ..The best scintigraphic images were obtained with monovalent HYNIC conjugate 15 using tricine and isonicotinic acid as coligands with HYNIC for coordination with (99m)Tc...
  47. ncbi Determination of triamcinolone, triamcinolone acetonide and fluocinonide in dosage forms
    D Agbaba
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia
    Acta Pol Pharm 47:15-7. 1990
    ..This method provides a precise and reproducible results (recovery ranged within 97.42-101.75%, variation coefficient ranged within 0.99-2.56%)...
  48. ncbi Synthesis of pyridine nucleotide analogs consisting of nicotinoylamino acids by means of transglycosidation reactions catalyzed by mammalian pyridine nucleotide transglycosidases
    Tadayoshi Imai
    Graduate Course of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:177-83. 2002
    ..They were inactive in regard to yeast alcohol dehydrogenase- and Thermoanaerobium brockii alcohol dehydrogenase (NADP dependent)-oxidation...
  49. ncbi Usefulness of graphical invariants in quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type
    Manish C Bagchi
    Drug Design, Development and Molecular Modelling Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Calcutta 700032, India
    J Mol Model 10:102-11. 2004
    ....
  50. ncbi Transition metal complexes of isonicotinic acid (2-hydroxybenzylidene)hydrazide
    Khlood S Abou-Melha
    Education College for Girls, Scientific Department, Abha, Assir, Saudi Arabia KSA
    Spectrochim Acta A Mol Biomol Spectrosc 70:162-70. 2008
    ..The tested compounds exhibited higher antibacterial activities...
  51. ncbi Phagocytic activity of macrophages against liposomes with conjugates of oxidized dextrans and isonicotinic acid hydrazide during modeling of phagocytosis disturbances in vitro
    S A Arkhipov
    Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 148:689-91. 2009
    ....
  52. ncbi New manganese(II) azido coordination polymers with nicotinic/isonicotinic acids as coligands: synthesis, structure, and magnetic properties
    Qian Yang
    Department of Chemistry and TKL of Metal and Molecule based Material Chemistry, Nankai University, Tianjin 300071, China
    Inorg Chem 49:3746-51. 2010
    The reactions of Mn(II) ions with azido ligands in the presence of nicotinic/isonicotinic acids gave two manganese(II) azido coordination polymers, [Mn(3)(L(1))(2)(N(3))(4)](n)...
  53. ncbi Effect of coligands on biodistribution characteristics of ternary ligand 99mTc complexes of a HYNIC-conjugated cyclic RGDfK dimer
    Shuang Liu
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA
    Bioconjug Chem 16:1580-8. 2005
    ..On the basis of their liver uptake and tumor/liver ratios, we believe that PDA has the advantage over TPPTS and ISONIC for the (99m)Tc-labeling of HYNIC-biomolecule conjugates...
  54. ncbi Detection and purification of a catalase-peroxidase from Mycobacterium sp. Pyr-1
    F Rafii
    Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    FEMS Microbiol Lett 173:285-90. 1999
    ..The enzyme was inhibited by sodium azide, glutathione, 2-mercaptoethanol, and isoniazid, but not by isonicotinic acid. The optimum enzyme activity was obtained at pH 4.5 and at 25 degrees C...
  55. ncbi The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
    Y Zhang
    MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 358:591-3. 1992
    ..Deletion of katG from the chromosome was associated with INH resistance in two patient isolates of M. tuberculosis...
  56. ncbi Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
    Samir A Carvalho
    FioCruz Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041 250 Rio de Janeiro, RJ, Brazil
    Bioorg Med Chem Lett 18:538-41. 2008
    ..The minimum inhibitory concentration (MIC) of the compounds 5a-d and 6c exhibited activity between 3.12 and 12.5 microg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis...
  57. ncbi Anti-inflammatory, analgesic, anticonvulsant and antiparkinsonian activities of some pyridine derivatives using 2,6-disubstituted isonicotinic acid hydrazides
    Mohamed A Al-Omar
    Department of Pharmaceutical Chemistry, King Saud University, Riyadh, Saudi Arabia
    Arch Pharm (Weinheim) 343:648-56. 2010
    ..The detailed synthesis, spectroscopic data, LD₅₀ and pharmacological activities of the synthesized compounds were reported...
  58. ncbi Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds
    Chieri Ida
    Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
    Biosci Biotechnol Biochem 72:868-71. 2008
    ..These results should provide useful information as to the mechanisms of cell differentiation...
  59. pmc Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid
    Michael J Hearn
    Department of Chemistry, Wellesley College, 106 Central Street, Wellesley, MA 02481, USA
    Eur J Med Chem 44:4169-78. 2009
    ....
  60. ncbi Amine modification of digested peptide at C-terminal end during protein digestion by protease
    Toshiyuki Ito
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Biol Pharm Bull 30:1838-43. 2007
    ....
  61. ncbi Isomeric ionic lithium isonicotinate three-dimensional networks and single-crystal-to-single-crystal rearrangements generating microporous materials
    Brendan F Abrahams
    School of Chemistry, University of Melbourne, Grattan Street, Parkville, Victoria 3010 Australia
    Inorg Chem 53:4956-69. 2014
    ..A dense 3D network with the formula, Li(inic) can be obtained in a reversible process by the removal of the water from the hydrated form and also by crystallization from a t-amyl alcohol solution. ..
  62. ncbi Picolinic and isonicotinic acids: a fourier transform microwave spectroscopy study
    Isabel Peña
    Grupo de Espectroscopia Molecular GEM, Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Unidad Asociada CSIC, Universidad de Valladolid, 47011 Valladolid, Spain
    J Phys Chem A 118:11373-9. 2014
    The rotational spectra of laser ablated picolinic and isonicotinic acids have been studied using broadband chirped pulse (CP-FTMW) and narrowband molecular beam (MB-FTMW) Fourier transform microwave spectroscopies...
  63. pmc Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons
    Kai Y Fan
    Northwestern University, Physiology, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 32:13718-28. 2012
    ..This adaptation may oppose hyperactivity but could also contribute to abnormal firing patterns in the parkinsonian STN...
  64. ncbi One pot green synthesis of Ag, Au and Au-Ag alloy nanoparticles using isonicotinic acid hydrazide and starch
    Sampath Malathi
    Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India
    Carbohydr Polym 111:734-43. 2014
    ....
  65. ncbi Multifunctional nanocomposites of lanthanide (Eu3+, Tb3+) complexes functionalized magnetic mesoporous silica nanospheres covalently bonded with polymer modified ZnO
    Bing Yan
    Department of Chemistry, Tongji University, State Key Lab of Water Pollution and Resource Reuse, Tongji University, Siping Road 1239, Shanghai, 200092, P R China
    Dalton Trans 42:9565-73. 2013
    ..Especially Eu(ZnO-MMS)(CNTA)3 and Tb(ZnO-MMS)(NTA)3 present high quantum yield values of 32.2% and 68.5%, respectively. The results will lay the foundation for further application in biomedical and biopharmaceutical fields...
  66. ncbi Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer
    Mansoor Abdul
    Department of Biology, Claflin University, Orangeburg, SC 29115, USA
    Acta Oncol 47:1546-50. 2008
    ..In prostate cancer, gamma-aminobutyric acid (GABA) has been previously reported to increase cellular proliferation via the ionotropic GABAa receptor (GABAar) and to promote cellular invasiveness via the metabotropic GABAb receptor...
  67. ncbi Probing hydrogen bond networks in half-sandwich Ru(II) building blocks by a combined 1H DQ CRAMPS solid-state NMR, XRPD, and DFT approach
    Michele R Chierotti
    Department of Chemistry and NIS Centre of Excellence, University of Torino, Via P Giuria 7, 10125 Torino, Italy
    Inorg Chem 53:139-46. 2014
    ..The hydration-dehydration process of the complex has been discussed in terms of structure and HB rearrangements. ..
  68. pmc Molecular and physiological effects of mycobacterial oxyR inactivation
    Eileen Pagan-Ramos
    Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    J Bacteriol 188:2674-80. 2006
    ..However, oxyR inactivation confers increased sensitivity to isonicotinic acid hydrazide, suggesting that the natural loss of oxyR in the tubercle bacillus contributes to the unusually high sensitivity of M. tuberculosis to isoniazid...
  69. ncbi A spin-canted Ni(II)4-based metal-organic framework with gas sorption properties and high adsorptive selectivity for light hydrocarbons
    Jia Li
    State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People s Republic of China
    Chem Commun (Camb) 50:9161-4. 2014
    ..65° and high adsorptive selectivity for light hydrocarbons...
  70. ncbi Acetylation genotype and phenotype in patients with systemic lupus erythematosus
    Mariola Rychlik-Sych
    Department of Pharmacogenetics, Medical University of Łódź, Muszynskiego 1, PL 90 151 Łódź, Poland
    Pharmacol Rep 58:22-9. 2006
    ..The concordance of 96.8% was achieved between acetylation phenotype and NAT2 genotype in the group of SLE patients studied...
  71. ncbi Isoniazid is not a lead compound for its pyridyl ring derivatives, isonicotinoyl amides, hydrazides, and hydrazones: a critical review
    T Scior
    Departamento de Farmacia, Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Col San Manuel, Mexico
    Curr Med Chem 13:2205-19. 2006
    ....
  72. pmc Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice
    E A Weinstein
    Center for Infection and Inflammation Imaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Antimicrob Agents Chemother 56:6284-90. 2012
    ..Since PET imaging is currently used clinically, this approach could be translated from preclinical studies to use in humans...
  73. ncbi Preparation of novel meta- and para-substituted N-benzyl protected quinuclidine esters and their resolution with butyrylcholinesterase
    Ines Primozic
    Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR 10 000 Zagreb, Croatia
    Molecules 17:786-95. 2012
    ..A series of racemic, (R)- and (S)-esters of quinuclidin-3-ol and acetic, benzoic, phthalic and isonicotinic acids were synthesized, as well as their racemic quaternary N-benzyl, meta- and para-N-bromo and N-methylbenzyl ..
  74. ncbi Synthesis and antibacterial activity of a new series of 3-[3-(substituted phenyl)-1-isonicotinoyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives
    Prashant Aragade
    Department of Pharmaceutical Chemistry, KLES College of Pharmacy, Vidyanagar, Hubli, Karnataka, India
    Arch Pharm (Weinheim) 342:361-6. 2009
    ..Among the series, compounds 4e, 4i, and 4k displayed an encouraging antibacterial activity profile as compared to the reference drug ampicillin against tested bacterial strains...
  75. ncbi Histologically proven isoniazid hepatoxicity in complicated tuberculous salpingitis
    Almut Semfke
    St George Medical Centre, Robert Koch Hospital, Leipzig, Germany
    Ther Adv Respir Dis 3:159-62. 2009
    ..After adaptation of the standard therapeutic regimen no further complications occurred...
  76. ncbi Ruthenium(II)-arene complexes with functionalized pyridines: synthesis, characterization and cytotoxic activity
    Sanja Grgurić-Sipka
    Faculty of Chemistry, University of Belgrade, Studentski trg 12 16, 11000 Belgrade, Serbia
    Eur J Med Chem 45:1051-8. 2010
    ..The reaction of 6 with 9-methyladenine was studied by (1)H NMR, (1)H, (1)H COSY and (1)H, (1)H NOESY spectroscopy...
  77. pmc Coligand effects on the solution stability, biodistribution and metabolism of the (99m)Tc-labeled cyclic RGDfK tetramer
    Shuang Liu
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Nucl Med Biol 35:111-21. 2008
    ..Among the three radiotracers evaluated in this tumor-bearing animal model, [(99m)Tc(HYNIC tetramer)(tricine)(TPPTS)] remained the best with respect to blood clearance, tumor uptake and target/background ratios...
  78. ncbi Structure elucidation of highly polar basic degradants by on-line hydrogen/deuterium exchange hydrophilic interaction chromatography coupled to tandem mass spectrometry
    Min Liu
    Analytical Research and Development, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    J Chromatogr A 1217:3598-611. 2010
    ..The integration of H/D exchange with HILIC has been described here for the first time and has been demonstrated to be a powerful structure elucidation tool via the study of degradants in 4-AMP...
  79. pmc Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases
    Ben Wiseman
    Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Biol Chem 285:26662-73. 2010
    ..The NAD(+) binding site is approximately 20 A from the entrance to the heme cavity and involves interactions primarily with the AMP portion of the molecule in agreement with the NMR saturation transfer difference results...
  80. ncbi Selective catechol-triggered supramolecular gel disassembly
    Jose A Saez
    Departament de Quimica Inorganica i Organica, Universitat Jaume I, Avda, Sos Baynat s n, 12071 Castello, Spain
    Chem Commun (Camb) 46:7996-8. 2010
    ..The results represent a unique example of molecular recognition associated to gel rupture which is of interest, for example, in controlled drug release applications...
  81. ncbi Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid
    Matthew G Stanton
    J Med Chem 50:3431-3. 2007
    ....
  82. ncbi Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1)
    Valerie Voigt
    Biozentrum of the Martin Luther University Halle Wittenberg, Halle, Germany
    J Pharm Pharmacol 65:582-90. 2013
    ..We investigated whether the H⁺-coupled amino acid transporter 1 (PAT1, SLC36A1), which is expressed in the intestinal epithelium, accepts arecaidine, arecoline, isoguvacine and other derivatives as substrates...
  83. ncbi In vitro effects of molecular nanosomal hybrid compositions with oxidized dextrans, conjugated with isonicotinic acid hydrazine on peritoneal macrophages
    V A Shkurupy
    Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 146:627-9. 2008
    ..Molecular nanosomal hybrid compositions containing dextrazide with 60-kDa dextran more effectively activated macrophages...
  84. ncbi Extent of M2 δ to ligand π-conjugation in neutral and mixed valence states of bis(4-isonicotinate)-bis(2,4,6-triisopropylbenzoate) dimetal complexes (MM), where M = Mo or W, and their adducts with tris(pentafluorophenyl)boron
    Philip Bunting
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States
    J Am Chem Soc 133:5873-81. 2011
    ....
  85. ncbi New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents
    Enrique Torres
    Unidad de Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada CIFA, University of Navarra, Pamplona, Spain
    Bioorg Med Chem Lett 21:3699-703. 2011
    ..Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research...
  86. doi Fluorinated metal-organic frameworks: advantageous for higher H2 and CO2 adsorption or not?
    Pradip Pachfule
    Physical Materials Chemistry Division, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India
    Chemistry 18:688-94. 2012
    ..The effect of partial introduction of fluorine atoms into the framework on the gas uptake properties of MOFs having similar structures has been analyzed experimentally and computationally in isostructural MOFs...
  87. ncbi "Diversity oriented synthesis" of functionalized chiral tetrahydropyridines: potential GABA receptor agonists and azasugars from natural amino acids via a sequential Baylis-Hillman reaction and RCM protocol
    Palakodety Radha Krishna
    D 206 B, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    J Comb Chem 10:426-35. 2008
    ....
  88. ncbi Interference of isonicotinyl hydrazone in the microbiological analysis of rifampicin from anti-tuberculosis FDC products containing isoniazid
    T T Mariappan
    Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab, India
    J Pharm Biomed Anal 36:643-7. 2004
    ....
  89. ncbi Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus
    Roustem Khazipov
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, 03756, USA
    Eur J Neurosci 19:590-600. 2004
    ..These results suggest that, in the immature hippocampus, GABA exerts dual (both excitatory and inhibitory) actions and that the excitatory component in the action of GABA may contribute to increased excitability during early development...
  90. ncbi Differential action of secreto-inhibitors on proopiomelanocortin biosynthesis in the intermediate pituitary of Xenopus laevis
    C H Dotman
    Department of Cellular Animal Physiology, Nijmegen Institute for Neurosciences, University of Nijmegen, The Netherlands
    Endocrinology 137:4551-7. 1996
    ....
  91. ncbi Developmental study of miniature IPSCs of CA3 hippocampal cells: modulation by midazolam
    C Rovira
    Institut des Neurosciences, Laboratoire de Neurobiologie du Developpement et du Vieillissement, UMR 7624, 9 Quai St Bernard, 75252, Paris Cedex 05, France
    Brain Res Dev Brain Res 114:79-88. 1999
    ..1 microM midazolam in both age groups. It is concluded that in immature and adult rats, synaptic GABAA receptors of CA3 were not different in their kinetic properties and sensitivity to midazolam...
  92. pmc Reciprocal developmental regulation of presynaptic ionotropic receptors
    Rostislav Turecek
    Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, L 335A, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 99:13884-9. 2002
    ..With age, the former role is transferred to the glycine receptor during the period in which postsynaptic glycinergic transmission is acquired...
  93. ncbi Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor
    S D Ugarte
    Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
    Neuroscience 95:795-806. 2000
    ..This finding was unexpected and suggests that a reduction in GABA(A) receptors can affect the production of antinociception by other analgesic drugs as well...
  94. ncbi Post-episode depression of GABAergic transmission in spinal neurons of the chick embryo
    N Chub
    Section on Developmental Neurobiology, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 85:2166-76. 2001
    ..We conclude that redistribution of intracellular [Cl(-)] during spontaneous episodes is likely to be an important postsynaptic mechanism involved in the post-episode depression of GABAergic transmission in chick embryo spinal neurons...
  95. ncbi A new layered zinc phosphate templated by protonated isonicotinate, [Zn2(C6H5NO2)2(HPO4)2]
    Guang Sheng Guo
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    Acta Crystallogr C 61:m87-9. 2005
    ..The layers are interconnected via hydrogen-bonding and heterocyclic ring interactions...
  96. ncbi Electrospray ionization mass spectrometry in studies of aluminium(III)-ligand solution equilibria
    Valerio B Di Marco
    Universita degli Studi di Padova, Dipartimento di Chimica Inorganica, Metallorganica ed Analitica, Via Marzolo 1, 35131 Padova, Italy
    Rapid Commun Mass Spectrom 17:2039-46. 2003
    ..The results compare well with the speciation data obtained from potentiometric, UV-visible spectroscopy, and NMR measurements. This agreement suggests the applicability of ES-MS to the study of more complicated aluminium-ligand systems...
  97. ncbi Surface-enhanced Raman spectroscopy using silver-coated porous glass-ceramic substrates
    Z Pan
    Department of Physics, Fisk University, Nashville, Tennessee 37208, USA
    Appl Spectrosc 59:782-6. 2005
    ..The porous glass ceramic with a nanometer-structured surface accommodated both test molecules and silver film. The absorbed molecules were therefore better interfaced with silver for surface-enhanced Raman scattering...
  98. ncbi Antitubercular isoniazid and drug resistance of Mycobacterium tuberculosis--a review
    Thomas Scior
    Department of Pharmacy, Benemerita Universidad Autonoma de Puebla, Puebla, Pue 72570, Mexico
    Arch Pharm (Weinheim) 335:511-25. 2002
    ..Both structures have been probed positively in a 3D modeling analysis...
  99. ncbi Effects of coligand variation on the in vivo characteristics of Tc-99m-labeled interleukin-8 in detection of infection
    Huub J J M Rennen
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Bioconjug Chem 13:370-7. 2002
    ..Protein doses to be administered were as low as 70 ng/kg bodyweight. At these low protein doses, side effects are not to be expected in the human system. This paves the way for infection imaging studies in patients...
  100. ncbi Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents
    Neelima Sinha
    Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46 47A, Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India
    Bioorg Med Chem Lett 15:1573-6. 2005
    ..Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H37Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis...
  101. ncbi Gramicidin S: a peptide model for protein glycation and reversal of glycation using nucleophilic amines
    V G Shakkottai
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    J Pept Res 60:112-20. 2002
    ..Hydrazines may be used to distinguish between the Schiff base and the ketoamine products formed at the initial stages of glycation...

Research Grants7

  1. CATALASE-PEROXIDASE CATALYSIS IN ANTIBIOTIC ACTIVATION
    RICHARD MAGLIOZZO; Fiscal Year: 2002
    ..The results of the proposed studies will advance a detailed understanding of the action of a first line antibiotic in current use to treat tuberculosis. ..
  2. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  3. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. MOLECULAR IMAGING OF MELANOMA BY EPR
    Graham Timmins; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. Antimycobacterial NO from KatG Activation of Isoniazid
    Graham Timmins; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Defining Moxifloxacin as a First-line TB Drug
    Eric Nuermberger; Fiscal Year: 2008
    ..Relevance: Results of these studies will help to define optimal treatment regimens for TB that can be used to design new clinical trials or, in some cases, directly applied to clinical practice. ..
  7. Molecular Surrogate for Melanoma Prevention
    Graham Timmins; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..