tocopherols

Summary

Summary: A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.

Top Publications

  1. ncbi Tocochromanol functions in plants: antioxidation and beyond
    Jon Falk
    Carlsberg Research Center, 10 Gamle Carlsberg Vej, DK 2500 Valby, Denmark
    J Exp Bot 61:1549-66. 2010
  2. ncbi Vitamin synthesis in plants: tocopherols and carotenoids
    Dean DellaPenna
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Annu Rev Plant Biol 57:711-38. 2006
  3. ncbi Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
    Barry Halliwell
    Department of Biochemistry, Faculty of Medicine, Singapore
    Am J Clin Nutr 81:268S-276S. 2005
  4. ncbi Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils
    Zsuzsa Varga
    First Department of Medicine, Health and Medical Science Centre, University of Debrecen, P O Box 19, H 4012 Debrecen, Hungary
    J Nutr Biochem 19:320-7. 2008
  5. pmc Unraveling the genetic basis of seed tocopherol content and composition in rapeseed (Brassica napus L.)
    Xingxing Wang
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China
    PLoS ONE 7:e50038. 2012
  6. pmc Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis
    Svetlana Porfirova
    Department of Lothar Willmitzer, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Proc Natl Acad Sci U S A 99:12495-500. 2002
  7. ncbi Alpha-, gamma- and delta-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells
    Shannon R Wells
    LSUHSC S Molecular and Cellular Physiology, Shreveport, LA 71130 3932, USA
    J Nutr Biochem 21:589-97. 2010
  8. pmc Orally active alpha-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer
    Tobias Hahn
    Robert W Franz Cancer Research Center, Earle A Chiles Research Institute, Providence Portland Medical Center, 4805 North East Glisan Street, Portland, OR 97213, USA
    Mol Cancer Ther 8:1570-8. 2009
  9. pmc Engineering vitamin E content: from Arabidopsis mutant to soy oil
    Alison L Van Eenennaam
    Monsanto Company, Calgene Campus, Davis, California 95616, USA
    Plant Cell 15:3007-19. 2003
  10. ncbi Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations
    Vilma B de Azeredo
    Departamento de Nutrição e Dietética, Faculdade de Nutrição, Universidade Federal Fluminense, Rio de Janeiro, Brazil
    Nutrition 24:133-9. 2008

Detail Information

Publications284 found, 100 shown here

  1. ncbi Tocochromanol functions in plants: antioxidation and beyond
    Jon Falk
    Carlsberg Research Center, 10 Gamle Carlsberg Vej, DK 2500 Valby, Denmark
    J Exp Bot 61:1549-66. 2010
    b>Tocopherols and tocotrienols, collectively known as tocochromanols, are lipid-soluble molecules that belong to the group of vitamin E compounds and are essential in the human diet...
  2. ncbi Vitamin synthesis in plants: tocopherols and carotenoids
    Dean DellaPenna
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Annu Rev Plant Biol 57:711-38. 2006
    Carotenoids and tocopherols are the two most abundant groups of lipid-soluble antioxidants in chloroplasts...
  3. ncbi Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
    Barry Halliwell
    Department of Biochemistry, Faculty of Medicine, Singapore
    Am J Clin Nutr 81:268S-276S. 2005
    ..We argue that tocopherols and tocotrienols may also exert direct beneficial effects in the gastrointestinal tract and that their return ..
  4. ncbi Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils
    Zsuzsa Varga
    First Department of Medicine, Health and Medical Science Centre, University of Debrecen, P O Box 19, H 4012 Debrecen, Hungary
    J Nutr Biochem 19:320-7. 2008
    ..In this study, we investigated the concentration-dependent effect of tocopherols and water-soluble metabolites on a key event in oxidative stress, for example, the oxidative burst in ..
  5. pmc Unraveling the genetic basis of seed tocopherol content and composition in rapeseed (Brassica napus L.)
    Xingxing Wang
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China
    PLoS ONE 7:e50038. 2012
    b>Tocopherols are important antioxidants in vegetable oils; when present as vitamin E, tocopherols are an essential nutrient for humans and livestock...
  6. pmc Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis
    Svetlana Porfirova
    Department of Lothar Willmitzer, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Proc Natl Acad Sci U S A 99:12495-500. 2002
    ....
  7. ncbi Alpha-, gamma- and delta-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells
    Shannon R Wells
    LSUHSC S Molecular and Cellular Physiology, Shreveport, LA 71130 3932, USA
    J Nutr Biochem 21:589-97. 2010
    Vitamin E, a micronutrient (comprising alpha-, beta-, gamma- and delta-tocopherols, alpha-, beta-, gamma- and delta-tocotrienols), has documented antioxidant and non-antioxidant effects, some of which inhibit inflammation and ..
  8. pmc Orally active alpha-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer
    Tobias Hahn
    Robert W Franz Cancer Research Center, Earle A Chiles Research Institute, Providence Portland Medical Center, 4805 North East Glisan Street, Portland, OR 97213, USA
    Mol Cancer Ther 8:1570-8. 2009
    ..Our finding of the high efficacy in this tumor model highlights the translational potential of oral alpha-TEA therapy...
  9. pmc Engineering vitamin E content: from Arabidopsis mutant to soy oil
    Alison L Van Eenennaam
    Monsanto Company, Calgene Campus, Davis, California 95616, USA
    Plant Cell 15:3007-19. 2003
    ..These findings demonstrate the utility of a gene identified in Arabidopsis to alter the tocopherol composition of commercial seed oils, a result with both nutritional and food quality implications...
  10. ncbi Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations
    Vilma B de Azeredo
    Departamento de Nutrição e Dietética, Faculdade de Nutrição, Universidade Federal Fluminense, Rio de Janeiro, Brazil
    Nutrition 24:133-9. 2008
    We determined the concentrations of retinol, carotenoids, and tocopherols in breast milk of adolescents and evaluated their associations with plasma levels and with maternal characteristics (period of lactation, body mass index, age of ..
  11. ncbi In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma
    Lars Muller
    Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
    Mol Nutr Food Res 54:731-42. 2010
    A comparative study investigated four tocopherols, four tocotrienols, and alpha-tocopheryl acetate on their antioxidative activities in five different popular assays, which were adapted to non-polar antioxidants...
  12. pmc Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients
    Viren Patel
    Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH, USA
    J Nutr 142:513-9. 2012
    The natural vitamin E family is composed of 8 members equally divided into 2 classes: tocopherols (TCP) and tocotrienols (TE). A growing body of evidence suggests TE possess potent biological activity not shared by TCP...
  13. ncbi Influence of growth temperature on the amounts of tocopherols, tocotrienols, and gamma-oryzanol in brown rice
    Steven J Britz
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 55:7559-65. 2007
    ..e., gamma-oryzanol), tocopherols, and tocotrienols...
  14. ncbi Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisation in adults
    Iris Kompauer
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Public Health Nutr 9:472-9. 2006
    Antioxidant nutrients like carotenoids, tocopherols and vitamin C have been suggested to protect against allergic rhinitis and allergic sensitisation but scientific evidence is scarce...
  15. pmc Cancer-preventive activities of tocopherols and tocotrienols
    Jihyeung Ju
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:533-42. 2010
    ..cancer-preventive effects is that high doses of alpha-tocopherol decrease the blood and tissue levels of delta-tocopherols. It has been suggested that gamma-tocopherol, due to its strong anti-inflammatory and other activities, may be ..
  16. ncbi Characterization of an Arabidopsis mutant deficient in gamma-tocopherol methyltransferase
    Eveline Bergmuller
    Max Planck Institute of Molecular Plant Physiology, Department of Lothar Willmitzer, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Mol Biol 52:1181-90. 2003
    ..Therefore, a shift in tocopherol composition or the absence of tocopherol has no major impact on the amounts of specific fatty acids or on lipid hydrolysis...
  17. ncbi Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells
    Pei Wang
    Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA
    Mol Carcinog 47:436-45. 2008
    ..Taken together, these findings suggest a role for JNK activation in mediating full length p73 expression and add to our understanding of the mechanisms of anticancer actions of alpha-TEA, a potential chemotherapeutic agent...
  18. ncbi Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biosci Bioeng 104:439-45. 2007
    ..In this review, we summarize the differences among alpha-, beta-, gamma-, delta-tocopherols and tocotrienols specifically regarding the following points; (i) their radical-scavenging efficacies and ..
  19. pmc Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis
    Richa Tiwary
    School of Biological Sciences C0900, Department of Nutritional Sciences A2703, University of Texas at Austin, Austin, Texas, United States of America
    PLoS ONE 5:e11865. 2010
    ..The objective of this study was to obtain additional insights into the mechanisms involved in alpha-TEA induced apoptosis in human breast cancer cells...
  20. ncbi Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Chem Phys Lipids 123:63-75. 2003
    ..The antioxidant properties were compared for alpha-, beta-, gamma- and delta-tocopherols and tocotrienols. The following results were obtained: (1)...
  21. pmc Tocopherols play a crucial role in low-temperature adaptation and Phloem loading in Arabidopsis
    Hiroshi Maeda
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 18:2710-32. 2006
    To test whether tocopherols (vitamin E) are essential in the protection against oxidative stress in plants, a series of Arabidopsis thaliana vitamin E (vte) biosynthetic mutants that accumulate different types and levels of tocopherols ..
  22. ncbi Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone
    S Ima-Nirwana
    Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    J Med Food 7:45-51. 2004
    ..Therefore, in conclusion, palm oil-derived gamma-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of the side effects of long-term glucocorticoid use...
  23. pmc Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature
    Hiroshi Maeda
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 20:452-70. 2008
    b>Tocopherols (vitamin E) are synthesized in plastids and have long been assumed to have essential functions restricted to these organelles...
  24. pmc Dissecting tocopherols content in maize (Zea mays L.), using two segregating populations and high-density single nucleotide polymorphism markers
    Xu Shutu
    National Maize Improvement Center of China, China Agricultural University, Beijing 100193, China
    BMC Plant Biol 12:201. 2012
    b>Tocopherols, which are vitamin E compounds, play an important role in maintaining human health. Compared with other staple foods, maize grains contain high level of tocopherols.
  25. ncbi Induction of cytokines by radioprotective tocopherol analogs
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 81:55-61. 2006
    Tocols are a family of eight isomers consisting of four tocopherols and four tocotrienols that exist in four isomeric forms: alpha (alpha), beta (beta), gamma (gamma), and delta (delta)...
  26. ncbi Simultaneous determination of tocopherols and tocotrienols in hazelnuts by a normal phase liquid chromatographic method
    Joana S Amaral
    REQUIMTE, Servico de Farmacognosia, Faculdade de Farmacia, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    Anal Sci 21:1545-8. 2005
    A normal-phase high-performance liquid chromatography (NP-HPLC) method for the determination of tocopherols and tocotrienols in hazelnuts is reported...
  27. ncbi Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis
    Sylvie Delanian
    service d oncologie radiothérapie, Hopital Saint Louis, 1 Ave Claude Vellefaux, 75010 Paris, France
    J Clin Oncol 23:8570-9. 2005
    ..In this study, we focus on the maximum response, how long it takes to achieve response, and changes after treatment discontinuation...
  28. ncbi Modification of mortality and tumorigenesis by tocopherol-mono-glucoside (TMG) administered after X irradiation in mice and rats
    Megumi Ueno
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiat Res 172:519-24. 2009
    ..These results suggest that TMG is effective in preventing radiation-induced bone marrow death in mice and in reducing mammary and pituitary tumors in rats even when it is administered after irradiation...
  29. ncbi Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis
    Andrea Hille
    Department of Radiotherapy and Radiation Oncology, University of Goettingen, Germany
    Strahlenther Onkol 181:606-14. 2005
    ..In a retrospective analysis the clinical benefit of the treatment with pentoxifylline/tocopherol on radiation-induced proctitis/enteritis was evaluated, compared to supportive care only...
  30. pmc Effect of vitamin supplementation on breast milk concentrations of retinol, carotenoids and tocopherols in HIV-infected Tanzanian women
    A L Webb
    Department of Nutrition, Harvard School of Public Health, Boston, MA 2115, USA
    Eur J Clin Nutr 63:332-9. 2009
    ..We examined the impact of vitamin supplementation during pregnancy and lactation on breast milk concentrations of retinol, carotenoids and tocopherols during the first year postpartum among 626 HIV-infected Tanzanian women.
  31. ncbi Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor
    Pankaj K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cytokine 56:411-21. 2011
    ..In conclusion, our current study suggests that induction of G-CSF resulting from TS administration is responsible for protection from 60Co γ-radiation injury...
  32. ncbi D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells
    Bipin Kumar
    Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262 0278, USA
    J Am Coll Nutr 21:339-43. 2002
    ..The purpose of this study was to measure and compare the effect of d-alpha-tocopheryl succinate (alpha-TS) in modifying radiation-induced chromosomal damage in human normal cells and cancer cells in culture...
  33. ncbi Effects of different origins and harvesting time on vitamin C, tocopherols, and tocotrienols in sea buckthorn (Hippophaë rhamnoides) berries
    Heikki Kallio
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Agric Food Chem 50:6136-42. 2002
    Vitamin C, tocopherols, and tocotrienols in berries of wild and cultivated sea buckthorn (Hippophaë rhamnoides L.) of different origins and harvesting dates were determined with HPLC. Wild berries of subsp...
  34. ncbi Triacylglycerols, glycerophospholipids, tocopherols, and tocotrienols in berries and seeds of two subspecies (ssp. sinensis and mongolica) of Sea Buckthorn (Hippophaë rhamnoides)
    Heikki Kallio
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Agric Food Chem 50:3004-9. 2002
    ..were compared in terms of triacylglycerols, glycerophospholipids, tocopherols, and tocotrienols. The berries of ssp. mongolica contained less oleic acid (4.6 vs 20.2%, p < 0...
  35. ncbi Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats
    Chisato Abe
    Department of Nutritional Sciences, Nagoya University of Arts and Sciences, 57 Takenoyama, Iwasaki, Nissin 470 0196, Japan
    Lipids 42:637-45. 2007
    ..The data also suggest that some amount of dietary vitamin E isoform is metabolized by a CYP-mediated pathway in the intestine during absorption...
  36. ncbi Enhancing vitamin E in oilseeds: unraveling tocopherol and tocotrienol biosynthesis
    Sarah C Hunter
    United States Department of Agriculture, ARS, Plant Genetics Research Unit, Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO 63132, USA
    Lipids 42:97-108. 2007
    Naturally occurring vitamin E, comprised of four forms each of tocopherols and tocotrienols, are synthesized solely by photosynthetic organisms and function primarily as antioxidants...
  37. ncbi The role of 2-methyl-6-phytylbenzoquinone methyltransferase in determining tocopherol composition in Synechocystis sp. PCC6803
    David K Shintani
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    FEBS Lett 511:1-5. 2002
    ..In addition, the enzyme also catalyzes the methylation of ring carbon 3 of 2-methyl-6-solanylbenzoquinol in the terminal step of plastoquinone biosynthesis...
  38. ncbi Lipids and tocopherols in serum and liver of female rats fed diets containing corn oil or cottonseed oil
    J D Radcliffe
    Department of Nutrition and Food Sciences, Texas Woman s University, Houston, TX, 77030, USA
    Plant Foods Hum Nutr 61:35-8. 2006
    ..and tissue concentrations of RRR-alpha-tocopherol (alpha-T) and RRR-gamma-tocopherol (gamma-T), the two major tocopherols in these oils...
  39. pmc Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol
    Amanda K Smolarek
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutrients 3:962-86. 2011
    Vitamin E consists of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail)...
  40. pmc Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F(2t) in serum or urine with prostate cancer risk: the multiethnic cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 20:1161-71. 2009
    ..We examine the association of antioxidants and 15-isoprostane F(2t) with risk of prostate cancer...
  41. ncbi Identification and quantification of carotenoids, tocopherols and chlorophylls in commonly consumed fruits and vegetables
    Jennifer Burns
    School of Biological Sciences, Royal Holloway, University of London, Egham Surrey TW20 0EX, UK
    Phytochemistry 62:939-47. 2003
    ....
  42. ncbi Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Institute, Nagoya 464 8681, Japan
    Nutr Cancer 51:13-24. 2005
    To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study...
  43. ncbi Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves
    Jon Falk
    Institute of Botany, University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    FEBS Lett 540:35-40. 2003
    ..While the vitamin E content is not affected in leaves, the level of plastoquinone is enhanced in leaves of transgenic lines during leaf senescence...
  44. ncbi Physiological and molecular responses of the isoprenoid biosynthetic pathway in a drought-resistant Mediterranean shrub, Cistus creticus exposed to water deficit
    Sergi Munne-Bosch
    Facultat de Biologia, Departament de Biologia Vegetal, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
    J Plant Physiol 166:136-45. 2009
    ..isoprenoid biosynthesis, together with the levels of the corresponding metabolites (chlorophylls, carotenoids, tocopherols and abscisic acid), in a drought-resistant Mediterranean shrub, Cistus creticus grown under Mediterranean field ..
  45. ncbi Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function
    Yoshiro Saito
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 49:1542-9. 2010
    ..It is suggested that, considering the bioavailability, α-T should be more effective than α-T3 against glutamate toxicity in vivo...
  46. ncbi Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea
    Clin Chem 50:582-8. 2004
    ..To further examine the role of GGT in relation to oxidative stress, we investigated the association between serum carotenoids and tocopherols, which have antioxidant properties, and serum GGT.
  47. ncbi Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change
    Martha Clare Morris
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Clin Nutr 81:508-14. 2005
    ..High intake of vitamin E from food (tocopherol), but not from supplements (which usually contain alpha-tocopherol), is inversely associated with Alzheimer disease...
  48. ncbi Tocopherols and tocotrienols in membranes: a critical review
    Jeffrey Atkinson
    Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada
    Free Radic Biol Med 44:739-64. 2008
    The familiar role of tocols (tocopherols and tocotrienols) as lipid-soluble chain-terminating inhibitors of lipid peroxidation is currently in the midst of a reinterpretation...
  49. pmc Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis
    E Collakova
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 127:1113-24. 2001
    b>Tocopherols, collectively known as vitamin E, are lipid-soluble antioxidants synthesized exclusively by photosynthetic organisms and are required components of mammalian diets...
  50. ncbi Plasma carotenoids, retinol, and tocopherols and risk of breast cancer
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 161:153-60. 2005
    The roles of carotenoids, retinol, and tocopherols in breast cancer etiology have been inconclusive...
  51. pmc Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines
    Sharon E Campbell
    Division of Hematology Oncology, Department of Internal Medicine, East Tennessee State University and James H, Quillen VA Medical Center, Johnson City, TN 37614, USA
    BMC Cancer 3:25. 2003
    b>Tocopherols are lipid soluble antioxidants that exist as eight structurally different isoforms. The intake of gamma-tocopherol is higher than alpha-tocopherol in the average US diet...
  52. ncbi Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:672-81. 2007
    Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer.
  53. ncbi Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status
    Timothy J Sontag
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:25290-6. 2002
    ..Since dietary sesamin also results in elevated tocopherol levels in vivo, this pathway appears to represent a functionally significant means of regulating vitamin E status...
  54. ncbi Biosynthesis, regulation and functions of tocochromanols in plants
    Laurent Mène-Saffrané
    Department of Biochemistry and Molecular Biology, 201 Biochemistry Building, Michigan State University, East Lansing, MI 48824 1319, USA
    Plant Physiol Biochem 48:301-9. 2010
    b>Tocopherols and tocotrienols have been originally identified as essential nutrients in mammals based on their vitamin E activity...
  55. ncbi Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes
    M Clara De Pascale
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Arch Biochem Biophys 447:97-106. 2006
    ..In this model, the tocopherols positively modulated only the reporter construct containing a consensus element for peroxisome proliferator-..
  56. ncbi The hydroxyphenylpyruvate dioxygenase from Synechocystis sp. PCC 6803 is not required for plastoquinone biosynthesis
    Dorothee Dähnhardt
    Institute of Botany, University of Kiel, Olshausenstrasse 40, D 24098, Kiel, Germany
    FEBS Lett 523:177-81. 2002
    ..Our results indicate that in Synechocystis in contrast to the situation in higher plants the 4-hydroxyphenylpyruvate dioxygenase is not required for the synthesis of plastoquinone...
  57. ncbi Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians
    A Elisabeth Hak
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Ave, Boston, Mass 02115 5804, USA
    Circulation 108:802-7. 2003
    ..Increased intake of carotenoids and vitamin E may protect against myocardial infarction (MI). However, prospective data on blood levels of carotenoids other than beta-carotene and vitamin E (tocopherol) and risk of MI are sparse...
  58. pmc Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity
    Sabrina A Bardowell
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    J Nutr 140:1901-6. 2010
    Human cytochrome P450 4F2 (CYP4F2) catalyzes the ω-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their catabolism to polar metabolites excreted in urine...
  59. ncbi Simultaneous determination of tocotrienols, tocopherols, retinol, and major carotenoids in human plasma
    Bee Lan Lee
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore 117597
    Clin Chem 49:2056-66. 2003
    ..However, methods for simultaneous measurement of these antioxidants are scarce. We developed and validated a new HPLC method for simultaneous determination of these vitamers in human plasma that uses a novel column-switching approach...
  60. ncbi Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells
    Marc Birringer
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, University of Potsdam, D 14558 Bergholz Rehbruecke, Germany
    J Nutr 132:3113-8. 2002
    ..These findings demonstrate that the trienols are metabolized essentially like tocopherols, i.e., by omega-oxidation followed by beta-oxidation of the side chain...
  61. ncbi Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study
    Yoshinori Ito
    Department of Public Health, Fujita Health University School of Health Sciences, Japan
    J Epidemiol 15:S140-9. 2005
    ..Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997...
  62. ncbi In vivo and in vitro studies of anticancer actions of alpha-TEA for human prostate cancer cells
    Li Jia
    Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas, USA
    Prostate 68:849-60. 2008
    ..The goal of this study was to determine in vivo anticancer efficacy of alpha-TEA against human prostate cancer cells and identify mechanisms of action...
  63. ncbi Revival of a resurrection plant correlates with its antioxidant status
    Ilse Kranner
    Institute of Plant Physiology, University of Graz, Schubertstrasse 51, A 8010 Graz, Austria
    Plant J 31:13-24. 2002
    ....
  64. ncbi Influence of ripeness and drying process on the polyphenols and tocopherols of Pistacia vera L
    Gabriele Ballistreri
    University of Catania, DOFATA, Catania, Italy
    Molecules 14:4358-69. 2009
    ..for the first time, the changes in the phenolics fraction (anthocyanins, flavonoids and stilbenes) and tocopherols of unpeeled Pistacia vera L. var. bianca with ripening, and the effect of the sun-drying process...
  65. ncbi Antiangiogenic potency of vitamin E
    Teruo Miyazawa
    Food and Biodynamic Chemistry Lab, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Ann N Y Acad Sci 1031:401-4. 2004
    ..Our findings suggest that T3 has potential as a therapeutic dietary supplement for preventing angiogenic disorders...
  66. ncbi Characterisation of plant tocopherol cyclases and their overexpression in transgenic Brassica napus seeds
    Rajeev Kumar
    RWTH Aachen University, Institute for Biology I Botany, Worringerweg 1, 52074 Aachen, Germany
    FEBS Lett 579:1357-64. 2005
    b>Tocopherols, collectively known as vitamin E, are only synthesised in photosynthetic organisms. Tocopherol cyclase (TC) catalyses the formation of the chromanol headgroup of the various tocopherol isoforms...
  67. ncbi Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans
    Han Yao Huang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 133:3137-40. 2003
    ..In view of the potential benefits of gamma- and delta-tocopherol, the efficacy of alpha-tocopherol supplementation may be reduced due to decreases in serum gamma- and delta-tocopherol levels. Additional research is clearly warranted...
  68. pmc Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures
    Vijay K Singh
    Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Radiat Res 54:973-88. 2013
    ..Eight major isoforms comprise the tocol group: four tocopherols and four tocotrienols...
  69. ncbi Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content
    Edgar B Cahoon
    Crop Genetics Research and Development, Pioneer Hi Bred, A DuPont Company, Experimental Station, Wilmington, Delaware 19880, USA
    Nat Biotechnol 21:1082-7. 2003
    ..of nontransformed plants, and a 10- to 15-fold increase in total vitamin E antioxidants (tocotrienols plus tocopherols)...
  70. ncbi Relevance of radioprotectors in radiotherapy: studies with tocopherol monoglucoside
    Cherupally Krishnan K Nair
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Bombay, India
    J Environ Pathol Toxicol Oncol 23:153-60. 2004
    ..Administration of TMG did not protect cancer cells from radiation damage because the growth curves of cancer cells treated with radiation alone and those treated with TMG after irradiation were not significantly different...
  71. ncbi Mobilized progenitor cells as a bridging therapy for radiation casualties: a brief review of tocopherol succinate-based approaches
    Vijay K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 11:842-47. 2011
    ....
  72. ncbi Antioxidant capacities of phenolic compounds and tocopherols from Tunisian pomegranate (Punica granatum) fruits
    Walid Elfalleh
    Inst des Régions Arides de Médenine, Laboratoire d Aridoculture et Cultures Oasiennes, Medenine 4119, Tunisia
    J Food Sci 76:C707-13. 2011
    ..Identified tocopherols seem to contribute in major part to the antioxidant activity of seed oil...
  73. ncbi A single extraction and HPLC procedure for simultaneous analysis of phytosterols, tocopherols and lutein in soybeans
    Margaret Slavin
    Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
    Food Chem 135:2789-95. 2012
    ..chromatography (HPLC) analysis method were developed and validated for simultaneous analysis of phytosterols, tocopherols and lutein (a carotenoid) in soybeans...
  74. ncbi Tocopherols and tocotrienols in sea buckthorn (Hippophae rhamnoides L.) berries during ripening
    Staffan C Andersson
    Horticulture, Swedish University of Agricultural Sciences, P O Box 103, SE 230 53 Alnarp, Sweden
    J Agric Food Chem 56:6701-6. 2008
    ..of particular interest for their high content of healthy phytochemicals, including vitamin E-related compounds (tocopherols and tocotrienols)...
  75. ncbi Changes of tocopherols, tocotrienols, γ-oryzanol, and γ-aminobutyric acid levels in the germinated brown rice of pigmented and nonpigmented cultivars
    Lean Teik Ng
    Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 61:12604-11. 2013
    This study examined the changes of tocopherols (Toc), tocotrienols (T3), γ-oryzanol (GO), and γ-aminobutyric acid (GABA) contents in germinated brown rice (GBR) of pigmented and nonpigmented cultivars under different germination ..
  76. ncbi Quantitation of fatty acids, sterols, and tocopherols in turpentine (Pistacia terebinthus Chia) growing wild in Turkey
    Bertrand Matthäus
    Institute for Lipid Research, Federal Research Center for Nutrition and Food, Piusallee 68 76, 48147 Münster, Germany
    J Agric Food Chem 54:7667-71. 2006
    The chemical composition (fatty acids, tocopherols, and sterols) of the oil from 14 samples of turpentine (Pistacia terebinthus L.) fruits is presented in this study...
  77. ncbi Effect of tocopherol-monoglucoside (TMG), a water-soluble glycosylated derivate of vitamin E, on hematopoietic recovery in irradiated mice
    Nadezda Cherdyntseva
    Cancer Research Institute of Tomsk Scientific Centre of Russian Acad Med Sci, Tomsk, Russia
    J Radiat Res 46:37-41. 2005
    ..These findings indicate that the radioprotective effect of TMG is apparently realized through its influence on hematopoietic system...
  78. pmc Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 15:4242-9. 2009
    b>Tocopherols are lipophilic antioxidants present in vegetable oils...
  79. pmc Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans
    Yang Zhao
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, USA
    J Agric Food Chem 58:4844-52. 2010
    b>Tocopherols and tocotrienols, collectively known as vitamin E, are essential antioxidant nutrients. The biological fates and metabolite profiles of the different forms are not clearly understood...
  80. ncbi Both alpha- and beta-carotene, but not tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in Dutch elderly men
    Brian Buijsse
    Division of Human Nutrition, Wageningen University, Wageningen, 6700 EV The Netherlands
    J Nutr 138:344-50. 2008
    ..This study does not indicate an important role for other carotenoids, tocopherols, or vitamin C in lowering the risk of CVD death.
  81. ncbi Normal phase high-performance liquid chromatography method for the determination of tocopherols and tocotrienols in cereals
    Gianfranco Panfili
    DISTAAM, Università degli Studi del Molise, Via De Sanctis, 86100 Campobasso, Italy
    J Agric Food Chem 51:3940-4. 2003
    The eight vitamers of vitamin E (alpha-, beta-, gamma-, and delta-tocopherols and -tocotrienols) have different antioxidant and biological activities and have different distributions in foods...
  82. ncbi Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate
    Young Hwa Kang
    Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea
    Int J Cancer 112:385-92. 2004
    ..Taken together, our findings suggest an important role of ROS generation in TOS-induced, caspase-independent apoptosis of cancer cells...
  83. ncbi Association of serum carotenoids and tocopherols with atopic diseases in Japanese children and adolescents
    Masayuki Okuda
    Department of Environmental Safety, Graduate School of Science and Technology, Yamaguchi University, Ube, Japan
    Pediatr Allergy Immunol 21:e705-10. 2010
    The present study assessed whether serum carotenoids and tocopherols are associated with atopic diseases (eczema and asthma) in 10- and 13-yr-olds in a Japanese community...
  84. ncbi A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project
    Joanne M Jordan
    Thurston Arthritis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, 27599 7330, USA
    Am J Epidemiol 159:968-77. 2004
    b>Tocopherols are lipid-soluble antioxidants that may protect against some conditions of aging...
  85. pmc Inhibition of lung cancer growth in mice by dietary mixed tocopherols
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Mol Nutr Food Res 53:1030-5. 2009
    b>Tocopherols are lipophilic antioxidants found in vegetable oils...
  86. ncbi Effect of cultivar, year grown, and cropping system on the content of tocopherols and tocotrienols in grains of hulled and hulless barley
    J Ehrenbergerova
    Mendel University of Agriculture and Forestry, Brno, Czech Republic
    Plant Foods Hum Nutr 61:145-50. 2006
    In a three-year period (2000-2002) total tocols (tocopherols and tocotrienols), content of vitamin E and its isomers (alpha-, beta+gamma-, delta-tocopherols and tocotrienols) were assessed in grain of 13 barley genotypes...
  87. ncbi Comparison of plasma antioxidant levels and related metabolic parameters between smokers and non-smokers
    Yu Wen Chiu
    Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 25:423-30. 2009
    ..003). We conclude that the lower plasma antioxidant levels and the higher level of hsCRP in smokers may lead to decreased protective efficacy compared with non-smokers. Further studies are warranted to support our hypothesis...
  88. ncbi Tocopherols and tocotrienols in wheat genotypes in the HEALTHGRAIN Diversity Screen
    Anna Maija Lampi
    Department of Applied Chemistry and Microbiology, University of Helsinki, Latokartanonkaari 11, P O Box 27, FI 00014 University of Helsinki, Finland
    J Agric Food Chem 56:9716-21. 2008
    ..The average total content of tocopherols and tocotrienols was 49.4 microg/g of dm, with a range of 27.6-79.7 microg/g of dm, indicating a 2...
  89. ncbi Relative changes in tocopherols, isoflavones, total phenolic content, and antioxidative activity in soybean seeds at different reproductive stages
    Vineet Kumar
    National Research Centre for Soybean Indian Council of Agricultural Research, Khandwa Road, Indore, M P, India 452 017
    J Agric Food Chem 57:2705-10. 2009
    ..Significantly higher values (P<0.05) were observed for tocopherols and isoflavones in immature seeds picked at late reproductive stages...
  90. ncbi The application of 19F magnetic resonance ex vivo imaging of three-dimensional cultured breast cancer cells to study the effect of delta-tocopherol
    Dorota Bartusik
    National Research Council Canada, Institute for Biodiagnostics West, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Anal Biochem 387:315-7. 2009
    ..We have grown 3D ex vivo breast cancer cell cultures in the hollow fiber bioreactor (HFBR). (19)F magnetic resonance imaging (MRI) was used to evaluate oxygen concentration in the cell suspension and thus its viability...
  91. ncbi Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells
    Beata Sacha
    Division of Animal Physiology, Department of Cell Biology, University of Salzburg, Salzburg, Austria
    J Neurosci Res 86:3526-35. 2008
    b>Tocopherols (vitamin E) are potent antioxidants as well as modulators of enzymes involved in signal transduction, like nitric oxide synthase (NOS)...
  92. ncbi Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 279:50700-9. 2004
    The effects of four natural tocopherols on the proliferation and signaling pathways were examined in the human mastocytoma cell line (HMC-1)...
  93. ncbi Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein
    Phillip Nava
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ont, Canada L2S 3A1
    Bioorg Med Chem 14:3721-36. 2006
    ..Thus, compounds have been prepared that allow the investigation of the rate of alpha-TTP-mediated inter-membrane transfer of alpha-tocopherol and to investigate the mechanism of alpha-TTP function at membranes of different composition...
  94. ncbi Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells
    Cha Sook You
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    J Nutr 135:227-32. 2005
    ..if A549 cells would metabolize tocochromanols via the omega-hydroxylase pathway, we compared the metabolism of tocopherols (alpha-, gamma-, delta-TOH) and tocotrienols (alpha-, gamma-, delta-T3) in these 2 cell lines...
  95. ncbi Vitamin E succinate promotes breast cancer tumor dormancy
    M P Malafa
    Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    J Surg Res 93:163-70. 2000
    ..Vitamin E succinate (VES) is the most potent antitumor analogue of vitamin E. Despite many reports of VES's antitumor activity in vitro, there is little information about its antitumor effects in vivo...
  96. ncbi Gas chromatographic determination of cholesterol and tocopherols in edible oils and fats with automatic removal of interfering triglycerides
    E Ballesteros
    Department of Analytical Chemistry, Faculty of Sciences, , Spain
    J Chromatogr A 719:221-7. 1996
    ..The method features a high throughput, minimal sample handling and analyte specificity (lipid material does not interfere)...
  97. ncbi Biotechnological production and application of vitamin E: current state and prospects
    Henry E Valentin
    Monsanto Co, Calgene Campus 1920 5th Street, Davis, CA 95616, USA
    Appl Microbiol Biotechnol 68:436-44. 2005
    Tocochromanols (tocopherols and tocotrienols) are important lipophilic antioxidants for animals and humans. Their biological activity is expressed as vitamin E activity...
  98. ncbi Contents of vitamin C, carotenoids, tocopherols, and tocotrienols in the subtropical plant species Cyphostemma digitatum as affected by processing
    Mohammed Al-Duais
    Institute of Ecology, Friedrich Schiller University Jena, Jena, Germany
    J Agric Food Chem 57:5420-7. 2009
    ..by reversed phase C30-high-performance liquid chromatography (HPLC) with diode array detection at 470 nm, while tocopherols and tocotrienols were analyzed by using normal phase HPLC with fluorescence detection (excitation, 292 nm; ..
  99. ncbi Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells
    Elke Reiter
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Biofactors 30:67-77. 2007
    The tocopherols (alpha, beta-, gamma-, and delta-tocopherol) and resveratrol are phytochemicals with alleged beneficial effects against atherosclerosis, vascular diseases and different cancers...
  100. ncbi A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers
    Helen E Gabriel
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 15:993-9. 2006
    ..smoking, a major risk factor for oropharyngeal cancer, is reported to alter oral levels of carotenoids and tocopherols. Such effects may be important because these nutrients, as well as retinoids, are putative chemoprotective ..
  101. ncbi Potentiation of anti-cancer effect by intravenous administration of vesiculated alpha-tocopheryl hemisuccinate on mouse melanoma in vivo
    Kentaro Kogure
    Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, Tokushima, 770 8505, Japan
    Cancer Lett 192:19-24. 2003
    ..However, TS-vesicle i.v. almost completely inhibited the tumor growth of all mice. Furthermore, the mean survival of the TS-vesicle i.v. group was 1.4-fold those of the control and TS i.p. groups...

Research Grants62

  1. Nutrition and Physical Activity Assessment Study (NPAAS)
    Ross L Prentice; Fiscal Year: 2013
    ..meat);and blood-derived nutritional measures, including carotenoids (fruits &vegetables), 1- and 3 -tocopherols (fats &oils), phospholipid fatty acids (fats &oils), and folate (fruits &vegetables) at the ..
  2. Prostate cancer prevention by tocopherols
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..an effective and safe strategy for prevention of PCa in men using a novel high (-tocopherol (T) rich mixture of tocopherols (?-TmT)...
  3. Forms of Vitamin E Have Opposing Effects on Inflammation
    Joan M Cook-Mills; Fiscal Year: 2011
    ..Furthermore, these tocopherols had direct effects on the endothelium during leukocyte migration...
  4. Prevention of estrogen-mediated mammary carcinogenesis by mixtures of tocopherols
    Nanjoo Suh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tocopherols are naturally occurring phenolic compounds and are the major forms of vitamin E in our body...
  5. Tocopherol-mediated inhibition of breast carcinogenesis
    Nanjoo Suh; Fiscal Year: 2010
    ..The long-term objective of our project is to identify and develop safe and efficacious agents, such as tocopherols, for prevention of breast cancer...
  6. Codrugs of Lipoic Acid and Tocopherol/Tocopheramine for Use as Photoprotective Ag
    Martha A Hass; Fiscal Year: 2011
    ..These novel compounds are derived from naturally-occurring vitamin E (TOC, tocopherols) and vitamin E analogs (tocopheramines) and lipoic acid or lipoic acid derivatives (LA)...
  7. A novel mouse prostate carcinogenesis model for dietary cancer prevention researc
    Chung S Yang; Fiscal Year: 2013
    ..carcinogenesis, and to determine the prostate cancer preventive activity of a -tocopherol (-T) rich mixture of tocopherols (-TmT) which, unlike -T, is a more effective chemopreventive agent...
  8. Epidemiologic Study of Brain Vitamin E, Diet &Age-Related Neurologic Diseases
    Martha Clare Morris; Fiscal Year: 2012
    ..The proposed multidisciplinary team conducted a pilot study that suggests brain levels of both gamma and alpha tocopherols are inversely related with AD neuropathology and severity of parkinsonian signs, and positively associated with ..
  9. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..advantages either as injectable or oral supplements) are equally or more effective than the corresponding tocopherols at the same and/or a lower dose when administered by intraperitoneal injections to diabetic nude mice ..
  10. Gamma-tocopherol as an effective anticancer agent for colon cancer
    Qing Jiang; Fiscal Year: 2010
    ..Recently, a study reported that mixed tocopherols, which are enriched in 3T, inhibited aberrant crypt foci formation in azoxymethane-induced colon cancer model...
  11. FAT SOLUBLE MICRONUTRIENTS IN HUMAN PLASMA AND TISSUES
    NORMAN KRINSKY; Fiscal Year: 1993
    ..platelet, adipose tissue, buccal mucosal cells, and normal and precancerous skin, with respect to the levels of tocopherols and carotenoids. Samples will be obtained from Dermatology Clinic patients, as well as from normal volunteers...
  12. GENE-DIET INTERACTIONS AND HEART DISEASE
    HANNAI CAMPOS; Fiscal Year: 2003
    ..GDAS markers are defined as common genetic variants that modulate the effect of intake of specific fatty acids, tocopherols, and carotenoids on atherosclerosis...
  13. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..of oxidative DNA damage (8-OHdG) and lipid peroxidation (isoprostanes), levels of lipid-soluble carotenoids and tocopherols (antioxidants) and serum ferritin (marker of potentially pro- oxidant iron intake), and genotyping for ..
  14. THE EFFECT OF SMOKING CESSATION ON PLASMA MICRONUTRIENTS
    James Shikany; Fiscal Year: 2001
    ..In the proposed study, concentrations of vitamin C, beta-carotene, folate, and alpha-tocopherols will be measured in all 220 randomized WISH subjects at baseline, prior to the intervention, and at the first 6-..
  15. Oxidative Stress, Antioxidants and Breast Cancer Risk
    Qi Dai; Fiscal Year: 2007
    ..will be quantified by gas chromatography/negative ion chemical ionization mass spectrometry, blood levels of tocopherols and carotenoids will be analyzed using HPLC methods, and genotypes of the enzymes involved in ROS ..
  16. ANTIMUTAGENESIS BY LYCOPENE AND SELENIUM IN LAC RODENTS
    Joseph Guttenplan; Fiscal Year: 2000
    ..and the mechanism of protection by a lycopene-rich mixture, and organic selenium with and without added tocopherols mixture, against spontaneous and carcinogen-induced mutagenesis in lac transgenic mice and rats in lung, colon, ..
  17. Novel CEHC Derivatives for Neuroinflamation
    William Wechter; Fiscal Year: 2003
    ..Moreover tocopherols are metabolized in vivo to yield carboxyethyl-hydroxyl chromane (CEHC) products that have been insufficiently ..
  18. Validation of Web-based Multimedia Dietary Assessment Tools
    Lenore Arab; Fiscal Year: 2010
    ..nitrogen for protein;urinary potassium for dietary potassium;and blood levels of nutrient (carotenoids and tocopherols) for fruits, vegetables, and nutritional supplement use...
  19. Effect of Antioxidants on Inflammatory Markers and FMVD
    Christopher Gardner; Fiscal Year: 2007
    ..Antioxidant nutrients, including vitamin C, carotenoids, tocopherols and selenium, may therefore be presumed likely to contribute to a decrease of endothelial dysfunction and to ..
  20. VITAMIN E: ASSAYS, DEFICIENCY, EFFECTS, NEW COMPOUND
    John Gilbert; Fiscal Year: 1980
    Two rapid, simple (requiring minimal pre-sample preparation), sensitive, and specific assay systems for tocopherols (vitamin E) in small samples of vertebrate and invertebrate tissue -- a rotifer bioassay and spectrofluorometry -- will ..
  21. LONG TERM EFFECTS OF CHOLESTEROL LOWERING DIETS IN WOMEN
    Phyllis Bowen; Fiscal Year: 1990
    ..serum lipids and lipoproteins, platelet function, peroxide load and serum and tissue retinoids, carotenoids and tocopherols; postprandial lipemic and glycemic responses, as well as several measures of physiological well-being, will ..
  22. Apoptotic Mechanisms of Tocotrienols in Mammary Cancer
    Paul Sylvester; Fiscal Year: 2004
    b>Tocopherols and tocotrienols represent the two subgroups in the vitamin E family of compounds...
  23. Antioxidant Supplementation,Oxidative Stress & Enduranc*
    Maret Traber; Fiscal Year: 2002
    ..Finally, the investigators plan to measure markers of inflammatory response, such as C-oxidants increase and vitamin E decreases these markers. ..
  24. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2009
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  25. Oxidative Stress and Vitamin E Requirements
    Maret Traber; Fiscal Year: 2005
    ..These proposed studies will further our goal of understanding the role of vitamin E in the amelioration of oxidative damage in aging and in chronic diseases, such as heart disease, diabetes and cancer. ..
  26. NATURAL VITAMIN E FORMS AS ANTI-INFLAMMATORY DRUGS
    Qing Jiang; Fiscal Year: 2006
    ..abstract_text> ..
  27. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  28. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  29. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2007
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  30. HUMAN BREAST CANCER CELL GROWTH INHIBITION BY VITAMIN E
    Kimberly Kline; Fiscal Year: 2008
    ..Proposed mechanistic studies have a high potential for identifying and characterizing dysregulated signaling pathways/events that are modifiable and therefore may serve as important molecular targets for treatment of breast cancer. ..
  31. HU/JHU Head and Neck Cancer Translational Research and *
    Xinbin Gu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. Interactions of Coenzyme Q10 with plasma tocopherols and their role in breast can
    Robert Cooney; Fiscal Year: 2008
    ..In addition we observe intriguing relationships between Coenzyme Q10 and plasma levels of alpha and gamma-tocopherols, as well as C-Reactive Protein that may have a significant impact on the interpretation of the role of these ..
  33. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  34. INTERNATIONAL CONFERENCE ON NUTRITION AND CANCER
    KEDAR PRASAD; Fiscal Year: 2004
    ..The proceedings of these conferences were published. The 9th International Conference on Nutrition and Cancer will be held in San Francisco on March 8-10, 2007. ..
  35. Antiatherogenic Properties of tert-Butylhydroquinone
    William Stone; Fiscal Year: 2004
    ..Commercial development should be accelerated since NIH has already conducted extensive toxicological studies with TBHQ. ..
  36. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  37. POTENTIAL CLINICAL IMPLICATIONS OF CAMP IN NEURAL TUMORS
    KEDAR PRASAD; Fiscal Year: 2003
    ..We have the experience with all the proposed techniques. Future studies will focus on the regulatory mechanisms for each of the differentiation and cancer genes. ..
  38. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..The levels of micronutrients (carotenoids and tocopherols) in serum and breast fluids also will be determined and used as a monitor of fruit and vegetable intake...
  39. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  40. Conference--Wound Healing : O2 and Emerging Therapeutics
    Chandan Sen; Fiscal Year: 2002
    ..Oxygen Sensing Oxidant Signaling & Redox Regulated Gene Expression Oxygen Therapy of Wounds Potential and Limitations of Clinical Gene Therapy for Wound Care Wound Angiogenesis Inflammation and Bacterial Control Clinical Care ..
  41. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  42. Allergic Condition Biomarkers and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2004
    ..Assuming a 0.05 significance level and 80 percent power, depending on the polymorphism, the proposed sample is large enough to detect a confounding-adjusted odds ratios of 0.6. ..
  43. Metabolic Signatures for Alzheimer's Disease
    Rima Kaddurah Daouk; Fiscal Year: 2009
    ..These studies may serve to highlight new impaired pathways in the disease and identify potential targets for drug developments. ..
  44. GENETICS OF AGED RELATED CATARACTS IN SALISBURY MARYLAND
    Nathan Congdon; Fiscal Year: 2002
    ....
  45. Vitamin E and Health
    Mohsen Meydani; Fiscal Year: 2004
    ..specifically bind and guide alpha-tocopherol to (sub)cellular destinations, and the metabolism of individual tocopherols. For example, recent observations on tissue specific functions of vitamin E identified by high-density ..
  46. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  47. Oxidative Damage in Smokers and Passive Smokers
    Gladys Block; Fiscal Year: 2003
    ..smokers 6) To determine the level of vitamin C required by smokers to attain the plasma vitamin C levels of non-smokers 7) To study the effect of supplemental vitamin C or antioxidant cocktail on other plasma antioxidants ..
  48. Molecular Risk Factors for Age-Related Maculopathy
    Debra Schaumberg; Fiscal Year: 2004
    ..abstract_text> ..
  49. NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases
    Joanne Jordan; Fiscal Year: 2008
    ..abstract_text> ..
  50. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2007
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  51. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  52. Vitamin E and atherosclerosis in LDLR-/-mice
    Mohsen Meydani; Fiscal Year: 2006
    ..abstract_text> ..
  53. Predicting Driver Safety in Parkinson's Disease
    Ergun Uc; Fiscal Year: 2007
    ..Fair and accurate means of detecting unfit drivers with PD will help mitigate the tragedy of motor vehicle crashes caused by these impaired individuals. ..
  54. NITRIC OXIDE REGULATION OF VASCULAR OXIDANT INJURY
    Bruce Freeman; Fiscal Year: 2007
    ..abstract_text> ..
  55. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  56. OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOME
    Theresa Scholl; Fiscal Year: 2005
    ....
  57. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2008
    ..The results could also contribute to the body of heath-related science that influences air quality standards and policies. [unreadable] [unreadable] [unreadable]..
  58. Brucella, Aging and Role of IL-17 in Host Defense
    Kevin High; Fiscal Year: 2005
    ..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
  59. BENIGN BREAST DISEASE AND RISK OF BREAST CANCER
    Rulla Tamimi; Fiscal Year: 2009
    ..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
  60. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  61. Long Term Toxicity of Di- and Tri-Chloroacetate
    Ezdihar Hassoun; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..