s nitrosoglutathione

Summary

Summary: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.

Top Publications

  1. ncbi Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
    S R Jaffrey
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 3:193-7. 2001
  2. ncbi Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin
    B Blanchard
    Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, F-91198 Gif sur Yvette (France
    Free Radic Res 34:189-91. 2001
  3. ncbi The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells
    Arsalan S Haqqani
    Institute for Biological Sciences, National Research Council, Ottawa, Ont, Canada
    Nitric Oxide 9:172-81. 2003
  4. pmc Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation
    Steven T Pullan
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    J Bacteriol 189:1845-55. 2007
  5. ncbi GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions
    Ratna Prasad
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Glia 55:65-77. 2007
  6. ncbi S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke
    Mushfiquddin Khan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cereb Blood Flow Metab 25:177-92. 2005
  7. ncbi Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    Tor C Savidge
    Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
    Gastroenterology 132:1344-58. 2007
  8. ncbi Flavohemoglobin Hmp affords inducible protection for Escherichia coli respiration, catalyzed by cytochromes bo' or bd, from nitric oxide
    T M Stevanin
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 275:35868-75. 2000
  9. ncbi Metabolism of S-nitrosoglutathione by endothelial cells
    H Zeng
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H432-9. 2001
  10. ncbi S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-)
    Astrid Schrammel
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Graz, Austria
    Free Radic Biol Med 34:1078-88. 2003

Detail Information

Publications219 found, 100 shown here

  1. ncbi Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
    S R Jaffrey
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 3:193-7. 2001
    ..Targets of NO include metabolic, structural and signalling proteins that may be effectors for neuronally generated NO. These findings establish protein S-nitrosylation as a physiological signalling mechanism for nNOS...
  2. ncbi Chemical evaluation of compounds as nitric oxide or peroxynitrite donors using the reactions with serotonin
    B Blanchard
    Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, F-91198 Gif sur Yvette (France
    Free Radic Res 34:189-91. 2001
    ..NO release from SIN-1 up to 86%. Only a small part of SIN-1 gave simultaneously .NO and O2(7-) able to link together to give peroxynitrite, but other oxidants could enhance .NO release from SIN-1...
  3. ncbi The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells
    Arsalan S Haqqani
    Institute for Biological Sciences, National Research Council, Ottawa, Ont, Canada
    Nitric Oxide 9:172-81. 2003
    ..We propose that formaldehyde dehydrogenase and glutathione reductase participate in a glutathione-dependent metabolic cycle that decreases protein S-nitrosation following exposure of cells to nitric oxide...
  4. pmc Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation
    Steven T Pullan
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    J Bacteriol 189:1845-55. 2007
    ....
  5. ncbi GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions
    Ratna Prasad
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Glia 55:65-77. 2007
    ..These observations suggest that GSNO exerts its protective effects in EAE by inhibition of cellular infiltration into the CNS by S-nitrosylation of p65, thereby modulating NF-kappaB-CAMs pathway in endothelial cells...
  6. ncbi S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke
    Mushfiquddin Khan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cereb Blood Flow Metab 25:177-92. 2005
    ..That GSNO protects the brain against ischemia/reperfusion injury by modulating NO systems, resulting in a reduction in inflammation and neuronal cell death was documented by the results...
  7. ncbi Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    Tor C Savidge
    Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
    Gastroenterology 132:1344-58. 2007
    ..Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not known...
  8. ncbi Flavohemoglobin Hmp affords inducible protection for Escherichia coli respiration, catalyzed by cytochromes bo' or bd, from nitric oxide
    T M Stevanin
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 275:35868-75. 2000
    ..The results demonstrate the role of Hmp in protecting respiration from NO stress and are discussed in relation to the energy metabolism of E. coli in natural O(2)-depleted environments...
  9. ncbi Metabolism of S-nitrosoglutathione by endothelial cells
    H Zeng
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 281:H432-9. 2001
    ..We conclude that the intracellular thiol pool causes the reduction of extracellular disulfides to thiols, which then directly reduce GSNO...
  10. ncbi S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-)
    Astrid Schrammel
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Graz, Austria
    Free Radic Biol Med 34:1078-88. 2003
    ..Our results indicate that concerted generation of (*)NO and O(2)(*)(-) may essentially contribute to nitrosative stress in inflammatory diseases...
  11. ncbi S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty
    Zoltan Kaposzta
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 106:3057-62. 2002
    ..S-nitrosoglutathione (GSNO) is a nitric oxide donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization after carotid angioplasty...
  12. pmc S-nitrosothiol depletion in amyotrophic lateral sclerosis
    Christopher M Schonhoff
    Department of Medicine and Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:2404-9. 2006
    ..SNO donor compounds may provide new therapeutic options for diseases such as ALS that are associated with deficient S-nitrosylation...
  13. ncbi S-nitrosoglutathione (GSNO) mediates brain response to hypoxia
    Chuang C Chiueh
    Pediatr Res 51:414. 2002
  14. ncbi Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione
    Zoltan Kaposzta
    Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Circulation 105:1480-4. 2002
    ..We evaluated its effectiveness in reducing embolization in patients with symptomatic carotid stenosis who already were taking aspirin...
  15. ncbi Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    Sangwon F Kim
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 310:1966-70. 2005
    ..Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs...
  16. ncbi Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis
    Janet Flatley
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    J Biol Chem 280:10065-72. 2005
    ..The data presented here reveal new genes important for nitrosative stress tolerance and demonstrate that methionine biosynthesis is a casualty of nitrosative stress...
  17. pmc Protection from experimental asthma by an endogenous bronchodilator
    Loretta G Que
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 308:1618-21. 2005
    ..Our results indicate that endogenous SNOs, governed by GSNOR, are critical regulators of airway responsivity and may provide new therapeutic approaches to asthma...
  18. ncbi Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst
    Andreas von Knethen
    Institute of Cell Biology, University of Kaiserslautern, Germany
    J Immunol 169:2619-26. 2002
    ..We conclude that NO participates in controlling the pro- vs anti-inflammatory phenotype of macrophages by modulating PPARgamma...
  19. ncbi S-nitrosylation signaling in cell biology
    Benjamin M Gaston
    Department of Pediatrics, Division of Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908 USA
    Mol Interv 3:253-63. 2003
    ..These recent insights regarding the bioactivities, molecular signaling pathways, and metabolism of endogenous S-nitrosothiols have suggested several new therapies for disease ranging from cystic fibrosis to pulmonary hypertension...
  20. ncbi The endoplasmic reticulum-related events in S-nitrosoglutathione-induced neurotoxicity in cerebellar granule cells
    Jie He
    Center for Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, P O Box 33, 15 Datun Road, Chaoyang District, Beijing 100101, PR China
    Brain Res 1015:25-33. 2004
    ..These effects indicate that ER is one of the NO targets in GSNO-induced neurotoxicity in cerebellar granule cells besides mitochondria...
  21. ncbi Regulation of the Salmonella typhimurium flavohemoglobin gene. A new pathway for bacterial gene expression in response to nitric oxide
    M J Crawford
    Howard Hughes Medical Institute, Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:34028-32. 1998
    ..These data unveil a new pathway for NO-dependent gene expression in S. typhimurium...
  22. ncbi A novel mechanism for upregulation of the Escherichia coli K-12 hmp (flavohaemoglobin) gene by the 'NO releaser', S-nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the glyA-hmp intergenic region
    J Membrillo-Hernandez
    The Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, UK
    Mol Microbiol 29:1101-12. 1998
    ..As GSNO and SNP upregulate hmp similarly, the NO released in the former case on reaction with homocysteine cannot be involved in hmp regulation...
  23. ncbi Nitrosoglutathione modulation of platelet activation and nitric oxide synthase expression in promotion of flap survival after ischemia/reperfusion injury
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    J Surg Res 119:92-9. 2004
    ....
  24. ncbi New insights into protein S-nitrosylation. Mitochondria as a model system
    Matthew W Foster
    Howard Hughes Medical Institute, Department of Medicine and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:25891-7. 2004
    ..Collectively, our results provide new insight into the determinants of S-nitrosothiol levels in subcellular compartments...
  25. pmc Metabolism of S-nitrosoglutathione in intact mitochondria
    M Steffen
    Department of Chemistry, University of Minnesota, 10 University Drive, Duluth, MN 55812, USA
    Biochem J 356:395-402. 2001
    ....
  26. ncbi Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils
    C C Corriveau
    Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 177:116-26. 1998
    ..009). These data suggest that NO does not directly affect neutrophil chemotaxis but may indirectly alter chemotactic responses by increasing IL-8 production via a cGMP-independent pathway...
  27. pmc Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells
    Benjaporn Buranrat
    Department of Pharmacology, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen 40002, Thailand
    World J Gastroenterol 13:6219-25. 2007
    ..To evaluate the effect of inflammatory cytokines on arylamine N-acetyltransferase 1 (NAT1), which is a phase-II enzyme involved in the biotransformation of aromatic and heterocyclic amines found in food, drugs and the environment...
  28. ncbi Effects of nitric oxide donors on vascular endothelial growth factor gene induction
    Hideo Kimura
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 296:976-82. 2002
    ..SNAP, GSNO, and NOC18 induced the accumulation of HIF-1alpha protein, while others did not. These results suggest that SNAP, GSNO, and NOC compounds are suitable for pharmacological studies in HIF-1-mediated VEGF gene activation by NO...
  29. ncbi Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide
    Liping Liu
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cancer Res 62:3037-43. 2002
    ..This may be of particular importance because such exposure may also lead to the formation of N-nitroso compounds that can act as alkylating agents...
  30. ncbi Alteration in intracellular calcium homeostasis reduces motor neuronal viability expressing mutated Cu/Zn superoxide dismutase through a nitric oxide/guanylyl cyclase cGMP cascade
    Hyun Jung Kim
    Department of Neurology, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Korea
    Neuroreport 13:1131-5. 2002
    ..This process induces oxidative stress generation that results in motor neuronal death through the guanylyl cyclase-cGMP dependent cascade...
  31. ncbi Regulation of TGF-beta1 gene transcription in human prostate cancer cells by nitric oxide
    Daren Wang
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Prostate 67:1825-33. 2007
    ..The purpose of this study was to investigate regulation of TGF-beta1 expression in human prostate cancer cells by nitric oxide (NO)...
  32. ncbi Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts
    Stefanie Heigold
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79104 Freiburg, Germany
    Carcinogenesis 23:929-41. 2002
    ..Apoptosis induction mediated by NO involves mitochondrial depolarization and is blocked by Bcl-2 overexpression...
  33. ncbi Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells
    Annette Keil
    Medizinische Klinik IV, University Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 62:401-11. 2002
    ..We therefore were interested in the regulation of gene expression in MC after treatment with NO...
  34. ncbi Modification of tubulin cysteines by nitric oxide and nitroxyl donors alters tubulin polymerization activity
    Lisa M Landino
    Department of Chemistry, The College of William and Mary, P O Box 8795, Williamsburg, Virginia 23187 8795, USA
    Chem Res Toxicol 20:1693-700. 2007
    ....
  35. ncbi Nitric oxide controls the light adaptive chromatic difference in receptive field size of H1 horizontal cell network in carp retina
    Tetsuo Furukawa
    Kyushu Institute of Technology, Iizuka, Fukuoka 820 8502, Japan
    Exp Brain Res 147:296-304. 2002
    ..These results are discussed in the context of two different hypotheses...
  36. ncbi Nitric oxide regulation of human peripheral blood mononuclear cells: critical time dependence and selectivity for cytokine versus chemokine expression
    Sarah E Macphail
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
    J Immunol 171:4809-15. 2003
    ..We conclude that exposure time to NO is critical to altered PBMC responsiveness and that NO inhibits expression of both Th1 and Th2 cytokines but not chemokines...
  37. ncbi Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors
    Inga Kwiecień
    Institute of Medical Biochemistry Collegium Medicum, Jagiellonian University, 31 034 Krakow, Poland
    Int J Biochem Cell Biol 35:1645-57. 2003
    ..A demonstration that rhodanese activity can be inhibited as a result of S-nitrosylation suggests the possible mechanism by which nitric oxide may regulate sulfane sulfur transport to different acceptors...
  38. ncbi [Antioxidant and prooxidant action of nitric oxide donors and metabolites]
    L L Gudkov
    Biofizika 52:503-9. 2007
    ..It is likely that the antioxidant action of nitric oxide derivatives is related to the reduction of ferry forms of hemoproteins and interaction of nitric oxide with lipid radicals...
  39. ncbi S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries
    Jacicarlos L Alencar
    Universite Louis Pasteur, Faculte de Pharmacie, Pharmacologie and Physico Chimie, Unité Mixte Recherche Centre National de la Recherche Scientifique, Illkirch, France
    J Pharmacol Exp Ther 307:152-9. 2003
    ..These differential effects of NO donors may be important for orientating their therapeutic indications...
  40. ncbi Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion
    Ella S M Ng
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Circ Res 94:559-65. 2004
    ..Our data suggest that inhaled NO can increase nitrosothiol production and these molecules may be a functional NO delivery system during cardiovascular disease...
  41. ncbi Role of S-nitrosation of cysteine residues in long-lasting inhibitory effect of nitric oxide on arterial tone
    Jacicarlos L Alencar
    Faculte de Pharmacie, Pharmacologie and Physico Chimie, Universite Louis Pasteur, Centre National de la Recherche Scientifique Unité Mixte Recherche 7034, 67401 Illkirch, France
    Mol Pharmacol 63:1148-58. 2003
    ..They suggest that S-nitrosation of tissue thiols is a mechanism of formation of local NO stores from which biologically active NO can subsequently be released...
  42. ncbi Proteomic analysis of S-nitrosylated proteins in mesangial cells
    Teresa Kuncewicz
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Mol Cell Proteomics 2:156-63. 2003
    ..These results broaden our knowledge of potential signal transduction pathways and other cell functions mediated by NO S-nitrosylation...
  43. ncbi Nitric oxide exposure of CC531 rat colon carcinoma cells induces gamma-glutamyltransferase which may counteract glutathione depletion and cell death
    Nils Erik Huseby
    Department of Medical Biochemistry, Faculty of Medicine, University of Tromsø, 9037 Tromsø, Norway
    Free Radic Res 37:99-107. 2003
    ..Thus, the enzyme will add to the protective measures of the tumor cells during nitrosative stress...
  44. ncbi Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation
    Mandy M Zeigler
    Dorothy M Davis Heart and Lung Research Institute, The Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210 1252, USA
    J Biol Chem 278:12894-902. 2003
    ..These data support the hypothesis that nitrosylation of protein thiol residues by nitric oxide is critical for promoting the survival of human monocytes...
  45. ncbi HIF-1 alpha protein as a target for S-nitrosation
    Vadim V Sumbayev
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 535:106-12. 2003
    ..In conclusion, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO...
  46. ncbi The haemoflagellate Trypanoplasma borreli induces the production of nitric oxide, which is associated with modulation of carp (Cyprinus carpio L.) leucocyte functions
    J P Scharsack
    Fish Disease Research Unit, School of Veterinary Medicine, Hannover, P O Box 711180, D 30545 Hannover, Germany
    Fish Shellfish Immunol 14:207-22. 2003
    ..Thus, in carp, T. borreli seems to induce high amounts of NO in vivo which are apparently not harmful for the parasite but which may interfere with co-ordinated interactions of activated cells aiming at the defence of the parasite...
  47. pmc Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
    Linda Lefievre
    Reproductive Biology and Genetics Group, Division of Reproductive and Child Health, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Proteomics 7:3066-84. 2007
    ..Potential targets for S-nitrosylation in human sperm include physiologically significant proteins not previously reported in other cells. Their identification will provide novel insight into the mechanism of action of NO in spermatozoa...
  48. ncbi Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion
    Paul Forsythe
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 170:287-93. 2003
    ..The inhibition of calpain is most likely mediated via nitrosylation of its active site thiol group. Calpain may represent a novel therapeutic target for the regulation of mast cell activity in inflammatory disorders...
  49. ncbi Inhibition of AtMYB2 DNA-binding by nitric oxide involves cysteine S-nitrosylation
    Viviane Serpa
    Laboratório de Expressão Gênica, Departamento de Bioquimica, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Biochem Biophys Res Commun 361:1048-53. 2007
    ....
  50. ncbi Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange
    Jongyun Heo
    Department of Biochemistry and Biophysics, University of North Carolina, 530 Mary Ellen Jones Building, Chapel Hill, North Carolina 27599 7260, USA
    Biochemistry 43:2314-22. 2004
    ..Our results suggest that formation of the Ras radical intermediate, Ras-S*, may perturb interactions between Ras and its guanine nucleotide substrate, resulting in enhancement of guanine nucleotide dissociation from Ras...
  51. ncbi Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible factor-1alpha (HIF-1alpha) in explants of human pial arteries
    Theresa L Wellman
    Department of Pharmacology, University of Vermont, Given Bldg, 89 Beaumont Ave, Burlington, Vermont 05405, USA
    FASEB J 18:379-81. 2004
    ..Thus we propose that the effect of NO on HIF-1alpha signaling is critically dependent on the form of NO and the physiological environment of the responding cell...
  52. ncbi S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from human brain
    Limei Tao
    Department of Chemistry and Biochemistry, Concordia University, 1455 de Masisonneuve Boulevard West, Montreal, Quebec, Canada H3G 1M8
    Biochemistry 41:6185-92. 2002
    ..This is due to efficient Förster energy transfer (R(0) approximately 17 A) between tryptophan donors and S-nitrosothiol acceptors...
  53. ncbi Midbrain neuronal cultures from parkin mutant mice are resistant to nitric oxide-induced toxicity
    R M Solano
    Department of Neurobiology, Hospital Ramon y Cajal, Ctra de Colmenar, Km 9, 28034 Madrid, Spain
    Neuropharmacology 51:327-40. 2006
    ..Our data show that, contrary to the expectations, and related to the enhanced production of GSH in parkin knockout mice, parkin-deficient dopamine neurons are less susceptible to toxicity by NO...
  54. ncbi Topically applied S-nitrosothiol-containing hydrogels as experimental and pharmacological nitric oxide donors in human skin
    A B Seabra
    Instituto de Quimica, Universidade Estadual de Campinas, CP 6154, CEP 13084 971, Campinas, SP, Brazil
    Br J Dermatol 151:977-83. 2004
    ..Endogenous S-nitrosothiols (RSNOs) store and transport NO within the body and can be used as exogenous sources of NO...
  55. ncbi Parasite killing in Plasmodium vivax malaria by nitric oxide: implication of aspartic protease inhibition
    Arun Sharma
    Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    J Biochem 136:329-34. 2004
    ..vivax infections for antimalarial chemotherapy and also biochemical adaptations of the malaria parasite for survival in the host erythrocytes with a better understanding of the protease substrate interactions...
  56. pmc Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation
    Kwan Hoon Moon
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 9410, USA
    FEBS Lett 579:6115-20. 2005
    ..The anti-nitrosocysteine antibody recognized the immunopurified ALDH2 only from the GSNO-treated samples. All these results indicate that S-nitrosylation of ALDH2 in intact cells leads to reversible inhibition of ALDH2 activity...
  57. pmc Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310
    Jing Qu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing, China
    Nucleic Acids Res 35:2522-32. 2007
    ..Together, this study may provide a novel molecular mechanism, which links nitrosative stress to APE1-associated physiological and pathological processes...
  58. ncbi Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor
    B Elmedal Laursen
    Department of Pharmacology, The Bartholin Building, University of Aarhus, Denmark
    Pulm Pharmacol Ther 19:179-88. 2006
    ....
  59. ncbi Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes
    Gong Jhe Wu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 101:1520-31. 2007
    ..Results of this study show that NO from exogenous and endogenous sources can induce apoptotic insults to human chondrocytes via a mitochondria-dependent mechanism...
  60. ncbi Effects of nitric oxide-active drugs on the discharge of subthalamic neurons: microiontophoretic evidence in the rat
    Pierangelo Sardo
    Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita degli Studi di Palermo, Corso Tukory, 129 90134 Palermo, Italy
    Eur J Neurosci 24:1995-2002. 2006
    ....
  61. ncbi Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron
    Anna V Kozhukhar
    Department of Obstetrics and Gynecology, Odessa State Medical University, Marshala Govorova Street 28, Odessa 65009, Ukraine
    Biochimie 88:411-8. 2006
    ..Treatment of those cells with N-acetyl cysteine (NAC) increased the amount of intracellular GSH and attenuated the NO effect and abolished the damage of mitochondria as well as 2-OG/iron release...
  62. ncbi Acute effects of exogenous nitric oxide on glucose uptake in skeletal muscle of normoglycaemic and diabetic rats
    Donovan McGrowder
    Department of Pathology, University of the West Indies, Kingston 7, Jamaica, West Indies
    Med Sci Monit 12:BR28-35. 2006
    ..The aim of this study was to investigate the role of NO released from its donors, S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP), on glucose uptake in skeletal muscle of normoglyceamic and type 2 diabetic rats...
  63. pmc Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols
    X Liu
    Department of Pharmacology, University of Glasgow
    Br J Pharmacol 111:1287-95. 1994
    ..The effects of pyrogallol and hydroquinone suggest that the NANCneurotransmitter is a superoxide anion-resistant, nitric oxide-releasing molecule and that neither S-nitrocysteine nor S-nitrosoglutathione is a suitable candidate for this...
  64. pmc Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus
    A J Barbier
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Br J Pharmacol 111:1280-6. 1994
    ..5 x 10-4 M GTN alone.7. It is concluded that S-nitrosothiols potently relax the rat gastric fundus, possibly by a cyclic GMP-dependent mechanism and S-nitrosothiols such as SNAC and GSNO may be involved in NANC neurotransmission...
  65. ncbi Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization
    Leonie F A Huitema
    Department of Biochemistry and Cell Biology, Utrecht University, P O Box 80 176, NL 3508 TD Utrecht, The Netherlands
    Eur J Pharmacol 542:48-53. 2006
    ..Furthermore, iron ions (30 microM) were detected to be released from SNP in the cell culture. These data show that the iron moiety of sodium nitroprusside, rather than nitric oxide inhibits mineralization...
  66. ncbi Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts
    Jamey W Burrow
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Surg Res 140:90-8. 2007
    ..In contrast, the concentration of nitric oxide (NO) is significantly reduced in these chronic ulcers. Addition of NO to diabetic wounds improves wound healing, but the mechanism for this effect is poorly understood...
  67. ncbi The role of water channel proteins and nitric oxide signaling in rice seed germination
    Hong Yan Liu
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 17:638-49. 2007
    ..These results suggest that water channels play an important role in seed germination, acting, at least partly, in response to the NO signaling pathway...
  68. ncbi Expression of Medicago truncatula genes responsive to nitric oxide in pathogenic and symbiotic conditions
    Alberto Ferrarini
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, 37134 Verona, Italy
    Mol Plant Microbe Interact 21:781-90. 2008
    ..This work clearly shows that NO-responsive genes behave differently depending on the plant organ and on the type of interaction, strengthening the need to consider regulatory networks, including different signaling molecules...
  69. ncbi The involvement of nitric oxide in ultraviolet-B-inhibited pollen germination and tube growth of Paulownia tomentosa in vitro
    Jun Min He
    School of Life Sciences, Shaanxi Normal University, Xi an 710062, People s Republic of China
    Physiol Plant 131:273-82. 2007
    ..However, the effects of c-PTIO, l-NAME and LY-83583 on the UV-B-inhibited pollen germination and tube growth were only partial, suggesting that there are NO-independent pathways in UV-B signal networks...
  70. ncbi Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland
    Hiromi Shimomura
    Department of Biochemistry, The Nippon Dental University at Niigata, 1 8 Hamaura cho, 951 8580, Japan
    Arch Oral Biol 49:691-6. 2004
    ..These results indicate that amylase release may be mediated through the NO/cGMP signaling pathway...
  71. ncbi NO donors inhibit Leishmania infantum cysteine proteinase activity
    L Salvati
    Dipartimento di Biologia, , Rome, Italy
    Biochim Biophys Acta 1545:357-66. 2001
    ..These data suggest that the L. infantum cysteine proteinase undergoes NO-mediated S-nitrosylation, thereby representing a possible mechanism of antiparasitic host defence...
  72. ncbi The biochemistry and physiology of S-nitrosothiols
    Neil Hogg
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Annu Rev Pharmacol Toxicol 42:585-600. 2002
    ....
  73. ncbi S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany
    Biochim Biophys Acta 1546:422-34. 2001
    ..Our results suggest that S-transnitrosylation of albumin by SNOC and GSNO could be a more favored mechanism for the formation of SNOALB in the circulation in vivo than S-nitrosation of albumin by NO itself...
  74. ncbi Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide
    P Jurasz
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Cancer Res 61:376-82. 2001
    ..We conclude that (a) human fibrosarcoma cells aggregate platelets via mechanism(s) that are mediated, in part, by MMP-2; (b) NO inhibits TCIPA, in part, by attenuating the release of MMP-2; and (c) these effects of NO are cGMP-dependent...
  75. ncbi Comparative effects of various nitric oxide donors on ferritin regulation, programmed cell death, and cell redox state in plant cells
    Irene Murgia
    Sezione di Fisiologia e Biochimica delle Piante, Dipartimento di Biologia, Universita degli Studi di Milano, Via Celoria, Milano, Italy
    J Plant Physiol 161:777-83. 2004
    ..Moreover, among the assortment of donors tested, only SNP caused programmed cell death and suppression of ROS-scavenging systems...
  76. ncbi Synergistic antiglioma action of hyperthermia and nitric oxide
    Kristina Janjetovic
    Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Serbia
    Eur J Pharmacol 583:1-10. 2008
    ..Therefore, the synergistic cytotoxicity of SNP and hyperthermia could result from NO-mediated suppression of protective autophagic response in glioma cells...
  77. ncbi Specific glutathione binding sites in pig cerebral cortical synaptic membranes
    R Janáky
    Tampere Brain Research Center, University of Tampere Medical School, Finland
    Neuroscience 95:617-24. 2000
    ..The glutathione binding sites may be an important, and for the most part unrecognized, component in signal transduction in the brain...
  78. ncbi Nitrergic relaxation in urethral smooth muscle: involvement of potassium channels and alternative redox forms of NO
    G Costa
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Naunyn Schmiedebergs Arch Pharmacol 364:516-23. 2001
    ..In addition, the production and/or release of alternative redox forms of NO, such as NO-, may be involved in neurotransmission processes in the urethra...
  79. ncbi Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate
    M J Finnen
    Prostrakan Pharmaceuticals, Buckholm Mill Brae, Galashiels TS1 2HB, UK
    Br J Dermatol 157:494-500. 2007
    ..Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO)...
  80. ncbi Pharmacological approaches to correcting the ion transport defect in cystic fibrosis
    Godfried M Roomans
    Department of Medical Cell Biology, University of Uppsala, Uppsala, Sweden
    Am J Respir Med 2:413-31. 2003
    ....
  81. ncbi Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthase
    Atsushi Kohjitani
    Department of Dental Anesthesiology, Okayama University Hospital of Dentistry, Shikata cho, Japan
    Anesthesiology 98:449-58. 2003
    ..The mechanisms inhibiting the NANC relaxation by ketamine and midazolam were investigated...
  82. pmc No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue
    Adam P Lothrop
    Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Given Building Room B413, Burlington, Vermont 05405, USA
    Biochemistry 48:6213-23. 2009
    ..7 in the full-length mammalian enzyme (83-142 nM), but surprisingly the truncated enzyme showed much stronger inhibition (25 nM). This contrasts with auranofin, where the absence of Sec more strongly perturbed inhibition...
  83. ncbi Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines
    V Hadjivassiliou
    Department of Biochemistry, University of Sussex, Brighton, United Kingdom
    Nitric Oxide 2:429-41. 1998
    ..v) Apoptosis was not the preferred death pathway in adult islets. (vi) We have found no evidence of human donor variation in the pattern of response to these treatments...
  84. ncbi Production of nitric oxide elevates nitrosothiol formation resulting in decreased glutathione in macrophages exposed to asbestos or asbestos substitutes
    Tamako Nishiike
    Department of Hygiene, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, 663 8501 Hyogo, Japan
    Arch Toxicol 79:83-9. 2005
    ....
  85. ncbi The myth of nitric oxide in central cardiovascular control by the nucleus tractus solitarii
    W T Talman
    Department of Veterans Affairs Medical Center, Iowa City, IA, USA
    Braz J Med Biol Res 30:515-20. 1997
    ..The studies suggest that S-nitrosocysteine, not nitric oxide, may be an interneuronal messenger for cardiovascular neurons in the NTS...
  86. ncbi Nitric oxide regulates the 26S proteasome in vascular smooth muscle cells
    Muneera R Kapadia
    Division of Vascular Surgery and the Institute for BioNanotechnology in Medicine, Northwestern University, 676 N St Clair Street 650, Chicago, IL 60611, USA
    Nitric Oxide 20:279-88. 2009
    ..This may be one mechanism by which NO exerts its effects on the cell cycle and inhibits cellular proliferation in the vasculature...
  87. ncbi Nitric oxide stimulates human sperm motility via activation of the cyclic GMP/protein kinase G signaling pathway
    Erica Miraglia
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, Turin, Italy
    Reproduction 141:47-54. 2011
    ..Our results suggest that NO stimulates human sperm motility via the activation of sGC, the subsequent synthesis of cGMP, and the activation of cGMP-dependent protein kinases...
  88. ncbi Nitric oxide donors attenuate clongenic potential in rat C6 glioma cells treated with alkylating chemotherapeutic agents
    Jir Jei Yang
    Institute of Neuroscience, Tzu Chi University, Hualien, Taiwan
    Neurosci Lett 418:106-10. 2007
    ..In contrast, production of NO as a result of iNOS induction, such as that occurring after surgical resection of brain tumors, may compromise the efficacy of carbamoylating chemotherapy...
  89. ncbi Differential mechanisms of urethral smooth muscle relaxation by several NO donors and nitric oxide
    A Garcia-Pascual
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Naunyn Schmiedebergs Arch Pharmacol 360:80-91. 1999
    ..It can be concluded that important differences exist in the mechanisms by which distinct NO donors relax urethral smooth muscle and they cannot be regarded simply as NO-releasing prodrugs...
  90. ncbi Nitric oxide and nitrosative stress tolerance in bacteria
    R K Poole
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Biochem Soc Trans 33:176-80. 2005
    ....
  91. ncbi Neocuproine inhibits the decomposition of endogenous S-nitrosothiol by ultraviolet irradiation in the mouse gastric fundus
    Nuran Ogulener
    Department of Pharmacology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey
    Eur J Pharmacol 485:269-74. 2004
    ....
  92. ncbi Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain
    W Roberts
    Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, UK
    J Thromb Haemost 7:2106-15. 2009
    ..This process requires two individual receptors: glycoprotein Ib (GPIb)-V-IX and integrin alpha(IIb)beta(3). However, little is known about the negative regulation of these events...
  93. pmc S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner
    Tarja Kokkola
    Department of Physiology, University of Kuopio, POB 1627, FIN 70211, Kuopio, Finland
    BMC Cell Biol 6:21. 2005
    ....
  94. ncbi Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways
    C D Jun
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, Korea
    J Immunol 162:3395-401. 1999
    ..Therefore, we conclude that PKC protects NO-induced apoptotic cell death, presumably nullifying the NO-mediated activation of JNK/SAPK, p38 kinase, and CPP32-like protease in RAW 264.7 macrophages...
  95. ncbi The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation
    M Feelisch
    The Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
    Mol Pharmacol 56:243-53. 1999
    ..The latter effect seemed to require biotransformation of ODQ. Collectively, these data reveal that ODQ interferes with various heme protein-dependent processes in vascular and hepatic tissue and lacks specificity for sGC...
  96. pmc Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2, 5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols
    A Y Kots
    Laboratory of Enzyme Chemistry, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Br J Pharmacol 129:1163-77. 2000
    ..The vasorelaxant activity of FPTO and FPDO is sGC-dependent and a predominant role is played by NO at FPTO concentrations below 1 microM. On the contrary, inhibition of platelet aggregation is only partially related to sGC activation...
  97. ncbi Effect of nitric oxide donors on oxygen-dependent cytotoxic responses mediated by neutrophils
    G Andonegui
    Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina
    J Immunol 162:2922-30. 1999
    ..e., 8 or 18 h) further increased cytotoxicity. Not only cytotoxic responses, but also the production of O2- and H2O2, and the release of myeloperoxidase were increased under these conditions...
  98. ncbi Nitric oxide induces dose-dependent CA(2+) transients and causes temporal morphological hyperpolarization in human neutrophils
    V M Loitto
    Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Cell Physiol 182:402-13. 2000
    ..e., Ca(2+) homeostasis, and also affect cell migration, e.g., through effects on F-actin turnover. Our results are discussed in relation to the complex mechanisms that govern basic cell shape changes, required for migration...
  99. ncbi Nitrosation of uric acid induced by nitric oxide under aerobic conditions
    Toshinori Suzuki
    School of Pharmacy, Shujitsu University, 1 6 1 Nishigawara, Okayama 703 8516, Japan
    Nitric Oxide 16:266-73. 2007
    ..These results indicate that under aerobic conditions nitric oxide can convert uric acid into its nitroso derivative, which can give a nitroso group to glutathione. Uric acid may act as a vehicle of nitric oxide in humans...
  100. pmc Comparison of the pharmacological profile of S-nitrosothiols, nitric oxide and the nitrergic neurotransmitter in the canine ileocolonic junction
    J G de Man
    Division of Gastroenterology, Faculty of Medicine, University of Antwerp UIA, Antwerpen Wilrijk, Belgium
    Br J Pharmacol 114:1179-84. 1995
    ..Therefore, we suggest NO, and not CysNO, SNAP or GSNO as the inhibitory NANC neurotransmitter in the canine ICJ...
  101. ncbi Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    Biochem Pharmacol 66:2355-63. 2003
    ..Taken together, these data suggest that BR should not be considered only as an endogenous antioxidant but also as a molecule with the potential ability to counteract intracellular nitrosative stress reactions...

Research Grants51

  1. Redox Determinants of Severe Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..At the conclusion of this project, we anticipate that we will be able to identify severe asthma redox phenotypes and to begin to develop therapies specific to individual biochemical disturbances. ..
  2. Nitroso/redox balance in myocardial infarction
    Joshua M Hare; Fiscal Year: 2013
    ..Our findings will have implications for developing new therapeutic strategies for myocardial infarction and other related common diseases. ..
  3. S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury
    Harvey E Marshall; Fiscal Year: 2012
    ..The knowledge gained from the proposed studies could lead to the development of new therapies that target inflammation in ALI/ARDS and other pulmonary disorders.. ..
  4. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ....
  5. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ....
  6. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2013
    ..abstract_text> ..
  7. Nitrosylation Mechanisms for Protection Against Neurovascular Inflammatory Injury
    Avtar K Singh; Fiscal Year: 2013
    ..The success of this proposed mechanistic intervention using S-nitrosoglutathione would provide a novel neurovascular approach to treating brain trauma. ..
  8. Reactive Species in Vascular Disease: Mechanisms of Injury
    Harry Ischiropoulos; Fiscal Year: 2013
    ..Overall the comprehensive large-scale study of protein structures and functional pathways will significantly improve our appreciation of S-nitrosylation in nitric oxide biology. ..
  9. Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical Site
    Stephen P Peters; Fiscal Year: 2013
    ..Companion protocols will examine corticosteroid resistance (RASS) and a possible genetic mechanism for resistance (IMMOST) in adults, and the efficacy of inhaled S-nitrosoglutathione (N30-201) (SNORT) in children. ..
  10. Identification of Novel Denitrosylases
    Jonathan S Stamler; Fiscal Year: 2013
    ....
  11. S-nitrosoglutathione regulation of intestinal barrier function in Crohn's disease
    Tor Savidge; Fiscal Year: 2010
    ..We plan to investigate whether this finding offers a novel approach to therapy for inflammatory permeability disorders. ..
  12. Modulation of Asthma by GSNO-based Therapies
    Loretta G Que; Fiscal Year: 2013
    ..Completion of these specific aims will critically advance our understanding of the potential impact and limitations of GSNO- based therapies as acute and chronic treatments for asthma. ! ..
  13. NITRIC-OXIDE SYNTHASE FORMS N-NO-PTERIN AND S-NO-CYS
    ELIZABETH GETZOFF; Fiscal Year: 2011
    ..The iNOS self-nitrosation characterized here appears appropriate to help control NO production in response to cellular conditions. ..
  14. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..Completion of this grant proposal may also offer new insights into the mechanisms whereby oxidants regulate the severity of inflammation. ..
  15. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2009
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  16. GSNO regulates HIF-1alpha by activation of PI 3-k/Akt
    Deborah Carver; Fiscal Year: 2009
    ..This environment is the perfect model in which to launch an independent academic career with the candidate's specified goals. ..
  17. Regulation of Cardiac Adrenergic Function by S-nitrosylation
    JONATHAN STAMLER; Fiscal Year: 2009
    ....
  18. Bronchopulmonary dysplasia and airway nitrogen chemistry
    Alix Paget Brown; Fiscal Year: 2005
    ..If this is true, it may lead to novel therapies for the prevention of BPD and thus reduce the toll of this disease on children. ..
  19. BIOCHEMICAL MECHANISM OF OXIDATIVE CATARACTOGENESIS
    Naseem Ansari; Fiscal Year: 2006
    ..Our studies in this grant will thus (i) delineate the role of ALDH1 in the detoxification of LDA and (ii) demonstrate the mechanism of regulation of ALDH1 under oxidative stress. ..
  20. ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSIS
    Lee Riley; Fiscal Year: 2001
    ....
  21. Hsp90, NOS3 and Cardioprotection
    Yang Shi; Fiscal Year: 2009
    ..abstract_text> ..
  22. REACTIVE NITROGEN & CEREBRAL ISCHEMIC INJURY
    MUSH KHAN; Fiscal Year: 2003
    ....
  23. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  24. Mechanism of Metabolism of S-Nitrosothiols
    Neil Hogg; Fiscal Year: 2010
    ..Importantly, these studies will point to a role of RSNO formation not simply as 'carriers'of NO bioactivity but as a distinct bifurcation in NO signaling pathways. ..
  25. SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES
    Neil Hogg; Fiscal Year: 2006
    ..The success of the program will be closely monitored by follow-up questionnaires to both students and participating faculty. ..
  26. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  27. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  28. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  29. Microvascular injury after Subarachnoid Hemorrhage
    Fatima A Sehba; Fiscal Year: 2010
    ....
  30. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  31. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..1 ..
  32. Mechanisms of Alveolar Fluid Transport
    Lin Liu; Fiscal Year: 2009
    ..An understanding of the mechanisms of fluid transport in the lung will provide valuable insights and directions toward therapeutic intervention in fetal lung diseases and the resolution of pulmonary edema. ..
  33. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..Evaluate the molecular mechanism by which NAC stimulates renal excretion of MeHg. IV. Test the hypothesis that urinary excretion of MeHg following an NAC oral challenge may be used as a new biomarker of MeHg exposure. ..
  34. The Glycocalyx and Endothelial Barrier Regulation
    RANDAL DULL; Fiscal Year: 2005
    ..This K08 will provide the foundation for a research career dedicated to understanding the molecular mechanisms of endothelial barrier regulation. ..
  35. "Ligand Independent" endocrine disruption by pesticides
    Patrick Wong; Fiscal Year: 2005
    ..abstract_text> ..
  36. Mechanisms of Nitric Oxide Mediated Cell Injury
    DAVID JOURD HEUIL; Fiscal Year: 2005
    ....
  37. MASS SPECTROMETRIC IDENTIFICATION OF NEW LIPID MEDIATORS
    Michael Balazy; Fiscal Year: 2005
    ....
  38. FLOW SHEAR INDUCED NF-KB MEDIATED REGULATION
    Sumathy Mohan; Fiscal Year: 2003
    ..Understanding of NF- kappaB signaling mechanisms in VCAM-1 regulation can also be applied to other inflammatory conditions. ..
  39. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  40. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
  41. Mechanisms of Alveolar Epithelial Cell Differentiation
    Lin Liu; Fiscal Year: 2006
    ..abstract_text> ..
  42. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..e. on nNOS immunoreactive dendrites or neurons in NTS. ..
  43. Particulate Matter/Mycoplasma Stress Interactions
    James Fabisiak; Fiscal Year: 2008
    ..abstract_text> ..
  44. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  45. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  46. Inhibition of s-nitrosoglutathione reductase for the treatment of asthma
    Sonal Sanghani; Fiscal Year: 2008
    ..The proposed work will lead to identification of compounds that will allow evaluating a new approach for preventing asthmatic episodes in asthma patients. [unreadable] [unreadable] [unreadable]..
  47. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2007
    ....
  48. MOLECULAR MECHANISMS OF LUNG SURFACTANT SECRETION
    Lin Liu; Fiscal Year: 2007
    ..Accomplishing the goals of this proposal will give a valuable direction to the therapy of pulmonary diseases such as neonatal respiratory distress syndrome. ..
  49. TGF-beta 1-regulated IL-8 expression in prostate cancer
    Zhongyun Dong; Fiscal Year: 2007
    ..TGF-beta1-stimulated IL-8 expression and IL-8 gene promoter activation in cells lacking the three TGF-beta signaling pathways as well as transcription factors involved will be determined. ..
  50. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2007
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  51. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....