decanoic acids

Summary

Summary: 10-carbon saturated monocarboxylic acids.

Top Publications

  1. pmc Activation of two different resistance mechanisms in Saccharomyces cerevisiae upon exposure to octanoic and decanoic acids
    J L Legras
    UMR 1083 Sciences pour l Oenologie INRA, SupAgro, Montpellier Cedex 1, France
    Appl Environ Microbiol 76:7526-35. 2010
  2. ncbi Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling
    Guanghai Yu
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, People s Republic of China
    Appl Biochem Biotechnol 163:729-43. 2011
  3. ncbi Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels
    Shohei Sumi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 299:H1174-82. 2010
  4. ncbi Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain
    R Bajgar
    Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006-8921, USA
    J Biol Chem 276:33369-74. 2001
  5. pmc KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions
    Matthias L Riess
    Anesthesiology Research Laboratories, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 51:483-91. 2008
  6. ncbi Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
  7. pmc K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart
    Peter J Hanley
    Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 542:735-41. 2002
  8. ncbi Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels
    L Wang
    Division of Cardiovascular Medicine, University of California, Davis 95616, USA
    Am J Physiol Heart Circ Physiol 280:H2321-8. 2001
  9. ncbi Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
    Derek J Hausenloy
    The Hatter Institute for Cardiovascular Studies, Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, UK
    Cardiovasc Res 55:534-43. 2002
  10. pmc In vitro killing of Candida albicans by fatty acids and monoglycerides
    G Bergsson
    Institute of Biology, University of Iceland, Reykjavik, Iceland
    Antimicrob Agents Chemother 45:3209-12. 2001

Research Grants

  1. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
  2. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
  3. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2001
  4. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
  5. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2002
  6. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
  7. NABTC Member Intitution Grant (UCSF Project Leader)
    Susan Chang; Fiscal Year: 2008
  8. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
  9. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
  10. IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCE
    David Busija; Fiscal Year: 2003

Detail Information

Publications188 found, 100 shown here

  1. pmc Activation of two different resistance mechanisms in Saccharomyces cerevisiae upon exposure to octanoic and decanoic acids
    J L Legras
    UMR 1083 Sciences pour l Oenologie INRA, SupAgro, Montpellier Cedex 1, France
    Appl Environ Microbiol 76:7526-35. 2010
    Medium-chain fatty acids (octanoic and decanoic acids) are well known as fermentation inhibitors...
  2. ncbi Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling
    Guanghai Yu
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, People s Republic of China
    Appl Biochem Biotechnol 163:729-43. 2011
    ..It was concluded that the method of rational screening of He-Ne Laser and NTG-induced mutants could efficiently improve the daptomycin production ability of S. roseosporus...
  3. ncbi Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels
    Shohei Sumi
    Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
    Am J Physiol Heart Circ Physiol 299:H1174-82. 2010
    ....
  4. ncbi Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain
    R Bajgar
    Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006-8921, USA
    J Biol Chem 276:33369-74. 2001
    ..Three independent methods indicate that brain mitochondria contain six to seven times more mitoK(ATP) per milligram of mitochondrial protein than liver or heart...
  5. pmc KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions
    Matthias L Riess
    Anesthesiology Research Laboratories, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 51:483-91. 2008
    ..Therefore, the effects of mKATP channel openers on mitochondrial function likely depend on the experimental conditions and the cell's underlying energetic state...
  6. ncbi Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
    ..These processes may involve opening of the mitoK(ATP) channel...
  7. pmc K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart
    Peter J Hanley
    Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 542:735-41. 2002
    ..We propose that pharmacological preconditioning may be related to partial inhibition of respiratory chain complexes...
  8. ncbi Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels
    L Wang
    Division of Cardiovascular Medicine, University of California, Davis 95616, USA
    Am J Physiol Heart Circ Physiol 280:H2321-8. 2001
    ..These data suggest that the lowering of mitochondrial calcium overload is a mechanism of cardioprotection in PC...
  9. ncbi Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
    Derek J Hausenloy
    The Hatter Institute for Cardiovascular Studies, Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, UK
    Cardiovasc Res 55:534-43. 2002
    ..We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) opening at reperfusion...
  10. pmc In vitro killing of Candida albicans by fatty acids and monoglycerides
    G Bergsson
    Institute of Biology, University of Iceland, Reykjavik, Iceland
    Antimicrob Agents Chemother 45:3209-12. 2001
    ..Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time...
  11. ncbi Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways
    Xi Ming Yang
    Department of Physiology, University of South Alabama, College of Medicine, Mobile 36688, USA
    J Am Coll Cardiol 44:1103-10. 2004
    ..An in situ model was used to test whether and how multiple occlusions at reperfusion can protect rabbit myocardium...
  12. ncbi KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes
    Xiu Lan Sun
    Laboratory of Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, PR China
    Neuropsychopharmacology 33:1336-42. 2008
    ..Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection...
  13. ncbi Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity
    G J Grover
    Metabolic and Cardiovascular Diseases Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey 08534-4000, USA
    J Pharmacol Exp Ther 297:1184-92. 2001
    ..Agents like BMS-191095 may owe their cardioprotective selectivity to selective mitochondrial K(ATP) activation...
  14. ncbi Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transition
    Vincent Piriou
    Departement d Anesthesie Reanimation, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Anesthesiology 100:581-8. 2004
    ..This study aimed at examining the effect of anesthetic preconditioning on mitochondrial permeability transition (MPT) pore opening...
  15. ncbi K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling
    Stefan Dröse
    Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Universitatsklinikum Frankfurt, Haus 26, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Biol Chem 281:23733-9. 2006
    ....
  16. ncbi Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel
    You Ping Wang
    First Department of Surgery, Kagawa Medical University, 1750 1, Ikenobe, Miki, Kita, Japan
    Cardiovasc Res 55:576-82. 2002
    ....
  17. ncbi Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats
    Takashi Horiguchi
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Stroke 34:1015-20. 2003
    ....
  18. pmc Mitochondrial potassium ATP channels and retinal ischemic preconditioning
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 47:2114-24. 2006
    ..To examine the mechanisms of ischemic preconditioning (IPC) related to the opening of mitochondrial KATP (mKATP) channels in the retina...
  19. ncbi Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels
    Hector F del Valle
    Department of Physiology, Pharmacology and Biochemistry, Favaloro University, Buenos Aires, Argentina
    Cardiovasc Res 55:642-59. 2002
    ..However, these structures appear to be altered in diabetes and thus, it would be possible that preconditioning does not develop in diabetic hearts...
  20. ncbi Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid
    Matthias L Riess
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 98:387-95. 2003
    ..The authors tested if effects of APC on NADH concentrations before, during, and after ischemia are reversible by 5-hydroxydecanoate (5-HD), a putative mitochondrial K channel blocker...
  21. ncbi The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart
    Yuankun Yue
    Department of Cell Biology and Neuroscience, MSB 2342, University of South Alabama, College of Medicine, Mobile 36688, USA
    Cardiovasc Res 55:681-9. 2002
    ..In addition, we tested whether protection from anisomycin, a p38 MAPK activator, is dependent on ROS production...
  22. ncbi Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat
    Yukinaga Nozawa
    Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, Japan
    Basic Res Cardiol 98:50-8. 2003
    ....
  23. ncbi Diazoxide protects against methylmalonate-induced neuronal toxicity
    Alicia J Kowaltowski
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Exp Neurol 201:165-71. 2006
    ..These results uncover new potential neuroprotective effects of mitoK(ATP) agonists under situations in which oxidative phosphorylation is inhibited...
  24. ncbi P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts
    Olaf Oldenburg
    Department of Physiology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    J Mol Cell Cardiol 35:1035-42. 2003
    ..7 +/- 9.5% and 27.7 +/- 4.6% infarction, respectively; P = n.s. vs. untreated hearts). These data provide strong evidence that P1075 does open mitoK(ATP) channels and protects the ischemic rabbit heart in a mitoK(ATP)-dependent manner...
  25. ncbi Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated hearts
    K Masui
    University of Yamanashi, Faculty of Medicine, Department of Anesthesiology, Yamanashi, Japan
    Eur J Anaesthesiol 23:123-9. 2006
    ..Thus, we investigated whether 5-hydroxydecanoate, a putative mitochondrial potassium channel blocker, prevents the cardioprotective effect of volatile anaesthetics...
  26. ncbi Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects
    Jason Peart
    Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Queensland 4217, Southport, Australia
    Cardiovasc Res 58:589-601. 2003
    ..Signaling in adenosine-mediated preconditioning is controversial. We examined roles of mitochondrial (mito) K(ATP) channels, protein kinase C (PKC) and nitric oxide (NO)...
  27. ncbi Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Mol Cell Cardiol 39:285-96. 2005
    ..In conclusion, short-term CR improves myocardial ischemic tolerance independent of the opening of KATP channels in both Y and O. CR-induced cardioprotection is associated with an increase in activated AMPK...
  28. pmc Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria
    Tatiana Brustovetsky
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Dr, Medical Science Building 549, Indianapolis, IN 46202, USA
    J Physiol 568:47-59. 2005
    ..Moreover, bongkrekic acid, another inhibitor of the ANT, inhibited K+ efflux similarly to ATP. These observations implicate the ANT in ATP-sensitive K+ transport in brain mitochondria...
  29. ncbi Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide
    Shoji Kimura
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Hypertension 45:438-44. 2005
    ....
  30. ncbi Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide
    Ying Xia
    Department of Physiology and Pharmacology, University of Western Ontario, Medical Sciences Building, London, Ont, Canada N6A 5C1
    J Mol Cell Cardiol 37:1063-7. 2004
    ..Mitochondrial K(ATP) channel activation could represent an effective approach to minimize the myocardial hypertrophic process...
  31. ncbi Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning
    Chun mei Cao
    Department of Physiology, 4 F, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
    J Pharmacol Exp Ther 312:644-50. 2005
    ..In conclusion, the study provides evidence that the K(Ca) channel triggers cardioprotection of IPC, which involves mPTP...
  32. ncbi Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heart
    Yue Liang Shen
    Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, China
    Acta Pharmacol Sin 25:22-8. 2004
    ..To test the hypothesis that cellular uncoupling induced by myocardial ischemia is mediated by activation of mitochondrial ATP-sensitive potassium channels (mitoKATP)...
  33. ncbi Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels
    Katare Gopalrao Rajesh
    Department of Surgery II, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi, Japan
    Int J Cardiol 96:41-9. 2004
    ..In this study we have demonstrated the role of ischemic preconditioning (IP) in preventing the reperfusion injury of the hypertrophied heart by activation of the depleted K(ATP) channels...
  34. ncbi Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart
    Andrzej Beresewicz
    Department of Clinical Physiology, Medical Centre of Postgraduate Education, 01 813 Warsaw, Poland
    Cardiovasc Res 63:118-29. 2004
    ....
  35. ncbi The direct physiological effects of mitoK(ATP) opening on heart mitochondria
    Alexandre D T Costa
    Dept of Biology, Portland State Univ, PO Box 751, Portland, OR 97207, USA
    Am J Physiol Heart Circ Physiol 290:H406-15. 2006
    ..These results provide decisive support for the hypothesis that mitochondria contain an ATP-sensitive K+ channel and establish the physiological consequences of mitoK(ATP) opening for mitochondria...
  36. ncbi Delayed preconditioning of the human myocardium: signal transduction and clinical implications
    Mahmoud Loubani
    Department of Integrative Human Cardiovascular Physiology and Cardiac Surgery, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    Cardiovasc Res 61:600-9. 2004
    ..Ischemic preconditioning confers cardioprotection in early and delayed phases. We investigated the delayed window of pharmacological and ischemic preconditioning in human myocardium, and the involvement of mitoKATP, PKC and p38MAPK...
  37. ncbi Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria
    David W Busija
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res Bull 66:85-90. 2005
    ..We conclude that BMS-191095 has selective effects on mitoK(ATP) channels while diazoxide also increases ROS production probably via inhibition of SDH...
  38. ncbi Pharmacological preconditioning with bradykinin affords myocardial protection through NO-dependent mechanisms
    Hiroshi Yoshida
    Department of Internal Medicine, Nippon Medical School, Tama Nagayama Hospital, Tama shi, Tokyo, Japan
    Int Heart J 46:877-87. 2005
    ..BK affords myocardial protection in the early phase of pharmacological preconditioning through a pathway that includes endogenous NO, PKC, and mitochondrial K(ATP) channels...
  39. ncbi Ischaemic preconditioning and a mitochondrial KATP channel opener both produce cardioprotection accompanied by F1F0-ATPase inhibition in early ischaemia
    Antti Ala-Rämi
    Department of Medical Biochemistry and Molecular Biology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    Basic Res Cardiol 98:250-8. 2003
    ..Thus mitochondrial K(ATP) channel opening and ischaemic preconditioning must share common mechanisms of action involving mitochondrial F(1)F(0)-ATPase, although involvement of the energy state in protection could not be proved...
  40. ncbi Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats
    Jan Neckar
    Institute of Physiology, Academy of Sciences of the Czech Republic and Centre for Experimental Cardiovascular Research, Videnska 1083, 142 20 Prague 4, Czech Republic
    Cardiovasc Res 55:567-75. 2002
    ..Our aim was to examine the role of mitochondrial ATP-sensitive potassium channels (K(ATP)) in this form of protection...
  41. ncbi Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide
    Y Wang
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267-0529, USA
    J Mol Cell Cardiol 33:2037-46. 2001
    ..NO which is generated upon ischemic stress triggers the opening of mitoK(ATP)channel as an end effector of cardioprotection during late PC...
  42. ncbi Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels
    D X Zhang
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Circ Res 89:1177-83. 2001
    ..activates these channels. The effect of O(2-.) may be associated with its direct action on the sulfhydryl groups of the channel protein...
  43. ncbi Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats
    Coert J Zuurbier
    Department of Anaesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Anesth Analg 106:135-42, table of contents. 2008
    ..In the present study, we examined how different anesthetics per se affect these variables of glucose metabolism, i.e., under similar hemodynamic conditions and in the absence of major surgical stress...
  44. ncbi Opening of mitochondrial K(ATP) channels attenuates the ouabain-induced calcium overload in mitochondria
    H Ishida
    Department of Physiology, Tokai University School of Medicine, Isehara, Japan
    Circ Res 89:856-8. 2001
    ..These results indicate that opening of mitoK(ATP) channels prevents a mitochondrial Ca(2+) overload in association with DeltaPsi(m) depolarization and thereby protects myocardium against ischemic damage...
  45. ncbi Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells
    M Akao
    Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD, USA
    Circ Res 88:1267-75. 2001
    ..Our findings identify a novel mitochondrial pathway that is protective against apoptosis. The results also pinpoint mitoK(ATP) channels as logical therapeutic targets in diseases of enhanced apoptosis and oxidative stress...
  46. ncbi Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels
    Giuseppe Colantuono
    Department of Emergency and Transplants, Section of Anaesthesia and Critical Care, University of Bari, Bari, Italy
    Clin Exp Pharmacol Physiol 35:64-71. 2008
    ..4. Hyperoxic mechanical ventilation, prior to ischaemia, reduces myocardial reperfusion injury. This is likely to occur through the induction of oxidative stress, which leads to myocyte mitoKATP channel opening...
  47. ncbi Na+/H+ exchanger inhibitor cariporide attenuates the mitochondrial Ca2+ overload and PTP opening
    Takako Toda
    Department of Pediatrics, Yamanashi University School of Medicine, Yamanashi, Japan
    Am J Physiol Heart Circ Physiol 293:H3517-23. 2007
    ..05). Our data indicate that cariporide attenuates [Ca(2+)](m) overload and MPT. Thus these effects might potentially contribute to the mechanisms of cardioprotection afforded by NHE inhibitors...
  48. ncbi Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation
    Jonathan P Brennan
    Cardiac Physiology Cardiovascular Division, The Rayne Institute, St Thomas Hospital, King s College London, SE1 7EH, UK
    Cardiovasc Res 72:313-21. 2006
    ....
  49. ncbi Sevoflurane protects stunned myocardium through activation of mitochondrial ATP-sensitive potassium channels
    T Hara
    Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
    Anesth Analg 92:1139-45. 2001
    ..IMPLICATIONS: Sevoflurane exerts a cardioprotective effect that is mediated via activation of adenosine triphosphate-sensitive potassium channels in ischemic canine hearts...
  50. ncbi Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytes
    Jun Lu
    Department of Pharmacology, School of Medicine, Xi an Jiaotong University, Xi an, 710061, PR China, and Research Centre, Sainte Justine Hospital, Montreal, Canada
    Eur J Pharmacol 549:133-9. 2006
    ..Adenosine and acetylcholine receptor antagonists and mitoKATP inhibitor were used to analyze pathways underlying the effects on postconditioning...
  51. ncbi Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes
    B C McPherson
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
    Circulation 103:290-5. 2001
    ..The resultant increase of intracellular free radical signals may be an important component of the signaling pathways by which morphine mimics preconditioning in cardiomyocytes...
  52. ncbi Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance
    Prasad V G Katakam
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Regul Integr Comp Physiol 292:R920-6. 2007
    ..Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K(ATP)...
  53. ncbi MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart
    Philippe Pasdois
    INSERM U441, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    J Bioenerg Biomembr 38:101-12. 2006
    ..It is concluded that opening the mitoK(ATP) channel mediates the preservation of mitochondrial structure-function via a mitochondrial matrix shrinkage and a reversible inactivation of complex II during prolonged ischemic insult...
  54. ncbi Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning
    Jan Minners
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
    Mol Cell Biochem 294:11-8. 2007
    ..Collectively these data support the hypothesis that diazoxide-mediated cytoprotection is independent of the conductance of the mK(ATP) channel and rather implicate mitochondrial respiratory inhibition-triggered ROS signaling...
  55. ncbi Anesthetic effects on mitochondrial ATP-sensitive K channel
    S Kohro
    Department of Anesthesiology Research, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 95:1435-340. 2001
    ..Cardioprotective effects of intravenous anesthetics may not be dependent on flavoprotein oxidation, but the administration of propofol or pentobarbital may potentially inhibit the cardioprotective effect of inhalational anesthetics...
  56. ncbi Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation
    Cevher Ozcan
    Department of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 282:H531-9. 2002
    ..Thus the cardioprotecive mechanism of K(+) channel openers includes direct attenuation of mitochondrial oxidant stress at reoxygenation...
  57. ncbi Exercise induces early and late myocardial preconditioning in dogs
    Raúl Domenech
    Department of Pathophysiology, Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Casilla 16038, Santiago 9, Chile
    Cardiovasc Res 55:561-6. 2002
    ..We tested the hypothesis that exercise induces myocardial preconditioning in dogs...
  58. ncbi Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene
    Robert M Smith
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
    Cardiovasc Res 55:553-60. 2002
    ..Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined...
  59. ncbi Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase
    Olaf Oldenburg
    Department of Physiology, MSB 3024, College of Medicine, University of South Alabama, Mobile 36688, USA
    Cardiovasc Res 55:544-52. 2002
    ..The aim of this study was to test whether ACh-induced ROS production could be seen in a vascular smooth muscle cell line, and, if so, to investigate the underlying signaling pathway...
  60. ncbi Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning
    Yoshito Ohnuma
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Am J Physiol Heart Circ Physiol 283:H440-7. 2002
    ..Together with the results of earlier studies showing mitochondrial K(ATP) opening by PKC, the present results suggest that mitochondrial K(ATP)-mediated cardioprotection occurs subsequent to PKC-epsilon activation by PC...
  61. ncbi Opening mitoKATP increases superoxide generation from complex I of the electron transport chain
    Anastasia Andrukhiv
    Dept of Biology, Portland State Univ, PO Box 751, Portland, OR 97207, USA
    Am J Physiol Heart Circ Physiol 291:H2067-74. 2006
    ..Myxothiazol stimulated mitoK(ATP)-dependent ROS production, whereas rotenone had no effect. This indicates that the superoxide originates in complex I (NADH:ubiquinone oxidoreductase) of the electron transport chain...
  62. ncbi Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart
    Tyson J MacCormack
    Ocean Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada AlC 5S7
    J Exp Biol 205:1411-8. 2002
    ..Results indicate that K(ATP) channels can modulate contractility in yellowtail flounder heart and are potentially important in cardiac hypoxia survival in this species...
  63. ncbi The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 94:841-8, table of contents. 2002
    ..The results indicate that mitochondrial and sarcolemmal K(ATP) channels mediate ethanol-induced preconditioning in dogs independent of alterations in systemic hemodynamics or coronary collateral blood flow...
  64. pmc Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning
    Paavo Korge
    University of California Cardiovascular Research Laboratory and Department of Medicine Cardiology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:3312-7. 2002
    ....
  65. ncbi Auxotrophy for uridine increases the sensitivity of Aspergillus niger to weak-acid preservatives
    Petter Melin
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Microbiology 154:1251-7. 2008
    ..Several other auxotrophic strains of A. niger were screened for sensitivity to acetic, sorbic and decanoic acids. Strains auxotrophic for either adenine or uridine were found to have enhanced sensitivity but, in contrast, ..
  66. ncbi Proposal of Pseudorhodobacter ferrugineus gen nov, comb nov, for a non-photosynthetic marine bacterium, Agrobacterium ferrugineum, related to the genus Rhodobacter
    Yoshihito Uchino
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Gen Appl Microbiol 48:309-19. 2002
    ..ferrugineus is 1%) and their major hydroxy fatty acid compositions are 3-hydroxy decanoic acids (3-OH 10:0) and 3-hydroxy tetradecanoic acids (3-OH 14:1). However, A...
  67. pmc Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis
    Song Gao
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
    FEBS J 275:5201-14. 2008
    ..Structural analysis of lipid A from the parental strain and derived mutants showed that O35ElpxX lacked two decanoic acids (C10:0), whereas O35ElpxL lacked one dodecanoic (lauric) acid (C12:0), suggesting that lpxX encoded decanoyl ..
  68. ncbi Loss of ripening capacity of pawpaw fruit with extended cold storage
    Federica Galli
    Department of Horticulture, University of Kentucky, Lexington, Kentucky 40546 0091, USA
    J Agric Food Chem 56:10683-8. 2008
    ..esters but increased levels of such off-flavor compounds as ethyl acetate, ethyl propionate, and hexanoic and decanoic acids. Alcohol acyltransferase (AAT) activity declined in cold-stored fruit but was not correlated with either total ..
  69. ncbi Study of the toxic effect of short- and medium-chain monocarboxylic acids on the growth of Saccharomyces cerevisiae using the CO2-auxo-accelerostat fermentation system
    Kaja Kasemets
    National Institute of Chemical Physics and Biophysics, Laboratory of Molecular Genetics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Int J Food Microbiol 111:206-15. 2006
    The effect of aliphatic monocarboxylic acids (formic, acetic, propionic, valeric, octanoic and decanoic acids) on the growth and metabolic activity of Saccharomyces cerevisiae S288C was studied, using continuous cultivation method - CO(2)-..
  70. ncbi Analysis of perfluorinated carboxylic acids in soils II: optimization of chromatography and extraction
    John W Washington
    United States Environmental Protection Agency, National Exposure Research Laboratory, 960 College Station Road, Athens, GA 30605, USA
    J Chromatogr A 1181:21-32. 2008
    ..in all three of our test soils, endogenous concentrations of all of our PFCA analytes, C(6) through C(10)-the lowest concentrations being roughly 30 pg/g of dry soil for perfluorinated hexanoic and decanoic acids in an agricultural soil.
  71. ncbi Lipid content and fatty acid composition in lemon wax
    Mario Vincenzo Russo
    Facoltà di Agraria DISTAAM, Università del Molise Via De Sanctis, 86100 Campobasso CB, Italy
    Ann Chim 92:469-76. 2002
    ..fractions the main fatty acids were hexadecanoic acid in all the fractions, cis-cis-9,12-octadecadienoic and decanoic acids in triglyceride (TG) fraction, dodecanoic and cis-9-octadecenoic acids in diglyceride (DG) fraction and ..
  72. ncbi Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains
    Catarina Barbosa
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, IBB CGB UTAD, Universidade de Tras os Montes e Alto Douro, Vila Real, Portugal
    J Biosci Bioeng 108:99-104. 2009
    ..The strain EC1118 produced significantly less medium chain fatty acids, hexanoic, octanoic and decanoic acids and their respective esters after nitrogen addition...
  73. ncbi Effects of perfluoro fatty acids on peroxisome proliferation and mitochondrial size in mouse liver: dose and time factors and effect of chain length
    H Permadi
    Unit for Biochemical Toxicology, Department of Biochemistry, Wallenberg Laboratory, Stockholm University, S 106 91, Stockholm, Sweden
    Xenobiotica 23:761-70. 2010
    ..e. perfluoroacetic, -butyric, -octanoic and -decanoic acids) at different doses (0-02 or 0-1% w/w of diet) for different periods of time (2-10 days), and effects on liver ..
  74. ncbi Production of hydroxy-fatty acid derivatives from waste oil by Escherichia coli cells producing fungal cytochrome P450foxy
    Tatsuya Kitazume
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Appl Microbiol Biotechnol 79:981-8. 2008
    ..Decanoic acid was most efficiently converted to omega-1 to omega-3 hydroxy decanoic acids in the order of omega-1>omega-2>omega-3, with a total product yield of 47%...
  75. ncbi Identification of aroma compounds in Parmigiano-Reggiano cheese by gas chromatography/olfactometry
    M Qian
    Department of Food Science and Nutrition, University of Minnesota, St Paul 55108, USA
    J Dairy Sci 85:1362-9. 2002
    ..Butanoic, hexanoic, octanoic, and decanoic acids are the major free fatty acids contributing to cheesy, lipolyzed aroma...
  76. ncbi Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats
    D R de Assis
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
    Exp Neurol 197:143-9. 2006
    We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain...
  77. ncbi Preparation and characterization of biodegradable electrospun polyanhydride nano/microfibers
    Qiuxiang Su
    School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China
    J Nanosci Nanotechnol 10:6369-75. 2010
    ..Therefore, the electrospun polyanhydride nano/microfibers exhibited strong potential as drug delivery vehicle and tissue engineering scaffold...
  78. ncbi Interaction of insulin with a triblock copolymer of PEG-(fumaric-sebacic acids)-PEG: thermodynamic and spectroscopic studies
    Pouneh S Pourhosseini
    Institute of Biochemistry and Biophysics, University of Tehran, PO Box 13145 1384, Tehran, Iran
    Biochim Biophys Acta 1774:1274-80. 2007
    ..Altogether, these observations indicate that (PEG-co-P(FA/SC)-co-PEG) triblock copolymer has similar effect(s) on both proteins...
  79. ncbi Structural and morphological changes of monolayers of a block copolymer with dendron and perfluoroalkyl side chains by mixing a perfluorooctadecanoic acid
    Koji Mitamura
    Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
    J Nanosci Nanotechnol 6:36-42. 2006
    ..Especially, the amphiphilicity of perfluorinated surfactant plays a role to the ordered array of the block copolymers...
  80. ncbi Aerosol-derived airway morphometry (ADAM) in patients with lung emphysema diagnosed by computed tomography--reproducibility, diagnostic information and modelling
    B Lehnigk
    Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig Maximilians University Munich, Ziemssenstrasse 1, 80336 Munich, Germany
    Eur J Med Res 12:74-83. 2007
    ..Average values and slopes of the EAD curve, as well as a power function for data fitting, were sensitive in the detection of type and severity of emphysema. In contrast, application of a lung model did not improve the results...
  81. ncbi Evolving lipid vesicles in prebiotic hydrothermal environments
    Ryo Furuuchi
    Department of Bioengineering, Nagaoka University of Technology, Nagaoka, 940 2188, Japan
    Orig Life Evol Biosph 35:333-43. 2005
    ..Phospholipid vesicles were destabilized by higher temperatures, and thus were found to be better suited to enhance synthetic reactions at lower temperatures...
  82. ncbi Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo
    J Müllenheim
    Klinik fur Anaesthesiologie, Heinrich Heine Universitat, Postfach 10 10 07, 40001 Dusseldorf, Germany
    Pflugers Arch 442:178-87. 2001
    ..001 versus LPC + EPC). We conclude that the combination of ischaemic LPC and EPC induces additive cardioprotection. KATP channel opening mediates the cardioprotective effects of ischaemic LPC and LPC + EPC...
  83. ncbi Identification of allyl esters in garlic cheese
    Klaus Herbrand
    Symrise GmbH and Co KG, Flavor and Nutrition, Mühlenfeldstrasse 1, 37603 Holzminden, Germany
    J Agric Food Chem 55:7874-8. 2007
    ..The identification of the allyl esters of acetic, butyric, hexanoic, heptanoic, octanoic, and decanoic acids is based on the correlation of their mass spectrometric data and chromatographic retention time data obtained ..
  84. ncbi Decomposition of perfluorocarboxylic acids (PFCAs) by heterogeneous photocatalysis in acidic aqueous medium
    Sri Chandana Panchangam
    Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan, ROC
    Chemosphere 77:242-8. 2009
    ..The oxygen present in the medium served both as an oxidant and an electron acceptor. The mechanistic details of PFCA decomposition and their corresponding mineralization are elaborated...
  85. pmc Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells
    Roy A Black
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 110:13272-6. 2013
    ..These mutually reinforcing mechanisms might have driven the emergence of protocells. ..
  86. pmc Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channels
    Peter J Hanley
    Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 547:387-93. 2003
    ..Our results open the possibility that beta-oxidation of 5-HD or metabolic intermediates of 5-HD may be responsible for the inhibitory effects of 5-HD on preconditioning of the heart...
  87. ncbi In vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranes
    Mohammed Nasser Ali Chisty
    Division of Pharmaceutics and Industrial Pharmacy, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
    Drug Dev Ind Pharm 28:1221-9. 2002
    ..The results of this research suggest that ABS is a good candidate for transdermal drug delivery...
  88. ncbi Transport of a lipophilic ionizable permeant (capric acid) across a lipophilic membrane (silicone polymer membrane) from aqueous buffered solutions in the presence of hydroxypropyl-β-cyclodextrin
    Richard V Hymas
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 101:2340-52. 2012
    ..The results of this study provide an approach that is useful in the mechanistic understanding of how cyclodextrins may enhance the passive absorption of highly lipophilic, low solubility drug molecules in the intestinal tract...
  89. ncbi A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial K(ATP) channel
    Rachael J Cerniway
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Basic Res Cardiol 97:232-8. 2002
    ....
  90. pmc Polycyclic aromatic hydrocarbons as plausible prebiotic membrane components
    Joost Groen
    Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands
    Orig Life Evol Biosph 42:295-306. 2012
    ..These data represent the first indication of a cholesterol-like stabilizing effect of oxidized PAH derivatives in a simulated prebiotic membrane...
  91. pmc Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pharmacology 90:110-6. 2012
    ..Eribis peptide 94 (EP 94) is a new enkephalin derivative which potently binds to the µ- and δ-opioid receptor. In this study, we determined the effects of EP 94 and potential mechanism(s) involved in cardioprotection of the rat heart...
  92. ncbi Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K(+) channel
    K Sakamoto
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 9 1 Shirokane 5 chome, Tokyo 108 8641, Minato ku, Japan
    Eur J Pharmacol 418:89-93. 2001
    ..Therefore, stimulation of adenosine receptors and opening of ATP-sensitive K(+) channels might be involved in the mechanism of histological protection by late preconditioning in the retina...
  93. ncbi Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector
    T Ichikawa
    Molecular Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Cancer Res 61:864-8. 2001
    ....
  94. ncbi [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis]
    Miki Takahashi
    Teikyo University Institute of Medical Mycology, Japan
    Med Mycol J 53:255-61. 2012
    ..These results suggest that all four fatty acids, and especially capric acid, have potential as substances supporting anti-Candida treatment...
  95. ncbi Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels
    B T Liang
    Department of Medicine, Cardiovascular Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Circ Res 84:1396-400. 1999
    ..These results provide direct evidence that the preconditioning-like effect of morphine in the intact heart can be exerted at the level of cardiac myocytes and is most likely the result of mitochondrial KATP channel activation...
  96. ncbi Percolation analysis in electrical conductivity of Madin-Darby canine kidney and Caco-2 cells by permeation-enhancing agents
    Makiko Washiyama
    Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Biol Pharm Bull 36:384-9. 2013
    ..The findings provide fundamental knowledge, not only on controlled drug delivery, but also on bio-nanotechnologies including the fabrication of biological devices...
  97. ncbi Molecular dynamics simulations of barley and maize lipid transfer proteins show different ligand binding preferences in agreement with experimental data
    Lorna J Smith
    Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, United Kingdom
    Biochemistry 52:5029-38. 2013
    ....
  98. ncbi Toxicant-induced alterations in two-dimensional electrophoretic patterns of hepatic and renal stress proteins
    F A Witzmann
    Molecular Anatomy Laboratory, Indiana University Purdue University, Columbus, USA
    Electrophoresis 17:198-202. 1996
    ..Furthermore, because nearly all of the proteins studied were constitutively expressed at detectable levels in both liver and kidney, the 2-DE stress protein pattern may be suitable to future toxicologic screening applications...
  99. pmc Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach
    Yoshihiko Kito
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 548:175-89. 2003
    ..The hyperpolarization shifted the threshold potential for generation of the 2nd component of slow waves to negative levels, presumably due to modulation of mitochondrial functions...
  100. ncbi Impact of the per-operatory application of GLIADEL wafers (BCNU, carmustine) in combination with temozolomide and radiotherapy in patients with glioblastoma multiforme: efficacy and toxicity
    Petra Miglierini
    Department of Radiotherapy, Institute of Oncology and Haematology, University Hospital Morvan, 2 avenue Foch, Brest, France
    Clin Neurol Neurosurg 114:1222-5. 2012
    ..Only a few studies have investigated this kind of treatment regimen and the impact in terms of survival and toxicity of the combination of Gliadel with TMZ and radiotherapy...
  101. ncbi Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice: formation of perfluorooctanoic acid in the liver
    Naomi Kudo
    Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1 1, Sakado, Saitama 350 0295, Japan
    Toxicol Sci 86:231-8. 2005
    ..The present study provided evidence that 8-2 telomer alcohol is converted into PFOA in vivo and that the PFOA formed produces biological effects in the liver of mice...

Research Grants14

  1. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
    ..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
  2. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  3. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2001
    ..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
  4. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  5. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2002
    ..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
  6. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  7. NABTC Member Intitution Grant (UCSF Project Leader)
    Susan Chang; Fiscal Year: 2008
    ..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
  8. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  9. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..1 ..
  10. IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCE
    David Busija; Fiscal Year: 2003
    ..Findings from this project may provide important information that can be used in future studies to design treatments to prevent or abort the cardiovascular complications of insulin resistance. ..
  11. CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTION
    DAVID TIPTON; Fiscal Year: 2002
    ..It is hoped that completion of these three aims will provide a detailed knowledge of the biological basis of TMJ destruction via synovial fibroblasts and MMP pathway. ..
  12. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    ....
  13. Cerebrovascular Dysfunction in Insulin Resistance
    David Busija; Fiscal Year: 2004
    ..We believe that our studies will result in new and important findings that will lead to improved therapies to reduce morbidity and mortality in IR individuals. ..
  14. Role of inositol trisphosphate in preconditioning
    Karin Przyklenk; Fiscal Year: 2004
    ....