Genomes and Genes
conjugated linoleic acids
Summary: A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.
Publications271 found, 100 shown here
- Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cellsMairead Coakley
Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland
Nutr Cancer 56:95-102. 2006..It is tempting to suggest that the ability of Bifidobacterium to produce such bioactive metabolites may be associated with the beneficial effects of bifidobacteria present in the human gastrointestinal tract...
- Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stressPaolo Bergamo
Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche CNR ISA, Via Roma 52, 83100, Avellino, Italy
Free Radic Biol Med 43:71-9. 2007..In conclusion our data indicate that the activation of detoxifying enzymes may be one of the mechanisms whereby dietary CLA down-regulates oxidative stress in MRL/lpr mice...
- Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 inductionChristine E Loscher
Department of Clinical Medicine, Institute of Molecular Medicine, Dublin, Ireland
J Immunol 175:4990-8. 2005....
- Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFASebastiano Banni
Universita degli Studi di Cagliari, Dipartimento di Biologia Sperimentale, Cittadella Universitaria, Cagliari, Italy
Lipids 39:1143-6. 2004..e., n-3, n-6 and n-9) PUFA families. It is likely that perturbation of PUFA metabolism by CLA will have an impact on eicosanoid formation and metabolism, closely linked to the biological activities attributed to CLA...
- Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific mannerSeong Ho Lee
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Carcinogenesis 27:972-81. 2006b>Conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, have anti-tumorigenic and pro-apoptotic properties in animal as well as in vitro models of cancer...
- Influence of organic diet on the amount of conjugated linoleic acids in breast milk of lactating women in the NetherlandsLukas Rist
Research Department, Paracelsus Hospital Richterswil, Bergstrasse 16, CH 8805 Richterswil, Switzerland
Br J Nutr 97:735-43. 2007..Hence, the levels of CLA and TVA in human milk can be modulated if breastfeeding mothers replace conventional dairy and/or meat products by organic ones. A potential contribution of CLA and TVA to health improvement is briefly discussed...
- Bioactive dietary long-chain fatty acids: emerging mechanisms of actionRobert S Chapkin
Faculty of Nutrition, Texas A and M University, College Station, TX, USA
Br J Nutr 100:1152-7. 2008....
- Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrolArion Kennedy
Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
J Lipid Res 50:225-32. 2009..Collectively, these data demonstrate for the first time that RSV prevents 10,12 CLA-mediated insulin resistance and delipidation in human adipocytes by attenuating inflammation and cellular stress and increasing PPARgamma activity...
- Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytesPaola Priore
Laboratory of Biochemistry, Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, 73100 Lecce, Italy
Biochim Biophys Acta 1771:1299-307. 2007Metabolic fate and short-term effects of a 1:1 mixture of cis-9,trans-11 and trans-10,cis-12-conjugated linoleic acids (CLA), compared to linoleic acid (LA), on lipid metabolism was investigated in rat liver...
- Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cellsSawitree Wongtangtintharn
United Graduate School of Agricultural Sciences, Kagoshima University, 1 21 24, Korimoto, Kagoshima 890 0065, Japan
J Nutr Sci Vitaminol (Tokyo) 50:137-43. 2004..The present study thus suggests that BCFA synthetically lowers the fatty acid biosynthesis by reducing the precursors, in addition to its direct inhibitory effect on fatty acid synthetase...
- Conjugated linoleic acids modulate UVR-induced IL-8 and PGE2 in human skin cells: potential of CLA isomers in nutritional photoprotectionAmy Storey
Department of Medicine, University of Liverpool, Liverpool, UK
Carcinogenesis 28:1329-33. 2007b>Conjugated linoleic acids (CLA), derivatives of linoleic acid found in food products, inhibit chemically induced skin cancers in mice. However, their potential photoprotective properties remain unexplored...
- Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophagesEwa Stachowska
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland al Powstancow Wlkp 72, 70 111 Szczecin, Poland
J Agric Food Chem 55:5335-42. 2007..Studies on conjugated linoleic acids (CLAs) as fatty acids with a potential anti-atherosclerotic function have recently been initiated...
- Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystemT C Jenkins
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
J Anim Sci 86:397-412. 2008....
- Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cellsMasao Yamasaki
Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889 2192, Japan
Biochim Biophys Acta 1735:176-84. 2005..10t, 12c-CLA directly degraded the isolated lysosomes from the rat liver. Our observations indicate that 10t, 12c-CLA induces mitochondria-related apoptosis accompanied by lysosomal destabilization in rat hepatoma cells...
- Conjugated linoleic acids have no effect on TNF alpha-induced adhesion molecule expression, U937 monocyte adhesion, and chemokine release in human aortic endothelial cellsSabine Schleser
Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
Atherosclerosis 186:337-44. 2006..b>Conjugated linoleic acids (CLA), which are natural ligands of PPARs, were demonstrated to have anti-inflammatory and anti-..
- Effect of different types of fibre supplemented with sunflower oil on ruminal fermentation and production of conjugated linoleic acids in vitroYanling Li
State Key Laboratory of Animal Nutrition, College of Animal Sciences and Technology, China Agricultural University, Beijing
Arch Anim Nutr 60:402-11. 2006..of different types of fibre supplemented with sunflower oil on ruminal fermentation and formation of conjugated linoleic acids (CLA) by mixed ruminal microorganisms...
- Metabolism of conjugated linoleic acids and 18 : 1 fatty acids by ruminal bacteria: products and mechanismsNest McKain
Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, UK
Microbiology 156:579-88. 2010....
- Biohydrogenation, duodenal flow, and intestinal digestibility of trans fatty acids and conjugated linoleic acids in response to dietary forage:concentrate ratio and linseed oil in dairy cowsJ J Loor
Unite de Recherches sur les Herbivores, INRA Theix, 63122 St Genes Champanelle, France
J Dairy Sci 87:2472-85. 2004..Duodenal flow of total conjugated linoleic acids (CLA) increased by 1.40 (LCO) to 3.01 (HCO) g/d with linseed oil...
- Rumen ciliate protozoa contain high concentrations of conjugated linoleic acids and vaccenic acid, yet do not hydrogenate linoleic acid or desaturate stearic acidEstelle Devillard
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Br J Nutr 96:697-704. 2006b>Conjugated linoleic acids (CLA) have been shown to improve human health. They are derived from the microbial conversion of dietary linoleic acid (cis-9,cis-12-18 : 2 (LA)) in the rumen...
- Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneysKristina Hoffmann
lnstitute of Biochemistry and Food Chemistry, University of Hamburg, Germany
Lipids 40:1057-62. 2005....
- Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acidsRobert T Dauchy
Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY, USA
Comp Med 57:377-82. 2007Melatonin and eicosapentaenoic and 10t,12c-conjugated linoleic acids suppress the growth-stimulating effects of linoleic acid (LA) and its metabolism to the mitogenic agent 13-(S)-hydroxyoctadecadienoic acid (13-(S)-HODE) in established ..
- Use of principal component analysis to investigate the origin of heptadecenoic and conjugated linoleic acids in milkV Fievez
Department of Animal Production, Ghent University, Proefhoevestraat 10, 9090 Melle, Belgium
J Dairy Sci 86:4047-53. 2003..Within the range of diets and cows studied here, we showed changes in cis-9,trans-11 conjugated linoleic acid to be mainly dependent on vaccenic acid supply and to a lesser extent on variation in desaturase activity...
- Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genesJ M Warren
Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis, California 95616, USA
Lipids 38:497-504. 2003..These initial results suggest that changes associated with energy homeostasis and insulin action may mediate the effects of t10,c12-CLA on lipid metabolism...
- Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulatorLinda Granlund
Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
J Lipid Res 44:1441-52. 2003A group of polyunsaturated fatty acids called conjugated linoleic acids (CLAs) are found in ruminant products, where the most common isomers are cis9, trans11 (c 9,t11) and trans10, cis12 (t10,c12) CLA...
- The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C miceArunabh Bhattacharya
Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio 78229 3900, USA
J Nutr 135:1124-30. 2005..b>Conjugated linoleic acids (CLA) were shown to decrease fat and increase lean mass in several animal studies...
- Conjugated linoleic acid--mediated apoptosis in Jurkat T cells involves the production of reactive oxygen speciesPaolo Bergamo
National Research Council, Institute of Food Sciences CNR ISA, Avellino, Italy
Cell Physiol Biochem 14:57-64. 2004..These results suggested that CLA can trigger apoptosis through an oxidative stress mediated by the PKC/NADPH oxidase pathway. The proposed mechanism provides a new insight into the anticancer activity of CLA...
- Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expressionEwa Stachowska
Department of Biochemistry, Pomeranian Medical University, Szczecin, Poland
Lipids 42:707-16. 2007..The inhibition of PGE2 synthesis (by CLA treatment) enhanced the phagocytosis process in macrophages...
- Hepatic lipid and carbohydrate metabolism in rats fed a commercial mixture of conjugated linoleic acids (Clarinol G-80)Anna M Giudetti
Laboratory of Biochemistry, Dept of Biological and Environmental Sciences and Technologies, University of Lecce, Italy
Eur J Nutr 44:33-9. 2005b>Conjugated linoleic acids (CLAs) exert numerous effects in animal models as well as in humans. Among other things, CLAs decrease plasma lipid levels and bring about hepatic steatosis...
- Effect of linseed oil supplementation on concentrations of (n-3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high-oleic acid sunflower oilK Eder
Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
J Anim Physiol Anim Nutr (Berl) 89:45-54. 2005..The results show that feeding the CLA oil reduced the formation of arachidonic acid and eicosanoids but enhanced the formation of long chain (n-3) PUFA and their incorporation into tissue lipids when compared with feeding SFO or HO-SFO...
- Prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) synthesis is regulated by conjugated linoleic acids (CLA) in human macrophagesE Stachowska
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, ul Zolnierska 48, Szczecin, Poland
J Physiol Pharmacol 60:77-85. 2009..COX-1 inhibition was resulting from competition of CLA and linoleic acid with arachidonic acid...
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel diseaseJosep Bassaganya-Riera
Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Gastroenterology 127:777-91. 2004..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
- Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytesJ Mark Brown
Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
J Lipid Res 44:1287-300. 2003....
- Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatmentLinda Granlund
Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
Biochim Biophys Acta 1687:11-22. 2005b>Conjugated linoleic acids (CLAs) are a group of polyunsaturated fatty acids found in ruminant products, where the predominant isomers are cis9, trans11 (c9,t11) and trans10, cis12 (t10,c12) CLA...
- Potentiation of the anti-tumour effect of docetaxel by conjugated linoleic acids (CLAs) in breast cancer cells in vitroAlemu Fite
Section of Surgical Oncology, Department of Surgery, University of Aberdeen, Medical School, Foresterhill, Aberdeen, Aberdeen, Scotland, UK
Prostaglandins Leukot Essent Fatty Acids 77:87-96. 2007..b>Conjugated linoleic acids (CLAs) also have anti-tumorigenic activity that elicits similar changes in oncogene expression to DOCT ..
- Methods for analysis of conjugated linoleic acids and trans-18:1 isomers in dairy fats by using a combination of gas chromatography, silver-ion thin-layer chromatography/gas chromatography, and silver-ion liquid chromatographyCristina Cruz-Hernandez
Agriculture and Agri Food Canada, Food Research Program, 93 Stone Rd West, Guelph, Ontario, Canada
J AOAC Int 87:545-62. 2004b>Conjugated linoleic acids (CLA) are octadecadienoic acids (18:2) that have a conjugated double-bond system...
- Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinomaErin Graves
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
Res Nurs Health 28:48-55. 2005..CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor-bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle...
- Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytesArion Kennedy
Department of Nutrition, University of North Carolina, Greensboro, NC 27402 6170, USA
J Nutr 138:455-61. 2008..Collectively, we demonstrate for the first time, to our knowledge, that 10,12 CLA antagonizes ligand-dependent PPARgamma activity, possibly via PPARgamma phosphorylation by ERK...
- Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese menUlf Riserus
Clinical Nutrition Research Unit, Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Box 609, 75125 Uppsala, Sweden
Am J Clin Nutr 80:279-83. 2004..Because c9,t11 CLA is the predominant CLA isomer in foods and is included in dietary weight-loss products, it is important to conduct randomized controlled studies that use c9,t11 CLA preparations...
- Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activationEd Wargent
Clore Laboratory for Life Sciences, University of Buckingham, Buckingham, MK18 1EG, UK
Lipids Health Dis 4:3. 2005..We have conducted three experiments with CLA in obese mice over three weeks, and one over eleven weeks. We have also investigated the effects of CLA isomers in PPARgamma and PPARalpha reporter gene assays...
- Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific mannerEileen F Murphy
Department of Food and Nutritional Sciences, University College, Cork, Ireland
J Nutr 137:2359-65. 2007..These may help our mechanistic understanding of the role of CLA in promoting gut function and health...
- The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cellsS Cusack
Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland
Prostaglandins Leukot Essent Fatty Acids 72:29-39. 2005..These results suggest a lack of cytotoxic effect of CLA on human osteoblast-like cells and tentatively suggest a possible beneficial effect on bone formation in humans...
- Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humansSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
Am J Clin Nutr 80:1626-33. 2004..However, little information on the effects of CLA on immune function is available, especially in humans. Furthermore, the effects of individual isomers of CLA have not been adequately investigated...
- Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant miceMaria Sörhede Winzell
Dept of Clinical Sciences, Medicine, Lund University, BMC, B11, SE 221 84 Lund, Sweden
Am J Physiol Endocrinol Metab 290:E347-54. 2006b>Conjugated linoleic acids (CLAs) and n-3 polyunsaturated fatty acids (PUFAs) improve insulin sensitivity in insulin-resistant rodents...
- Effect of CLA supplementation on immune function in young healthy volunteersH J Song
Rowett Research Institute, Aberdeen, UK
Eur J Clin Nutr 59:508-17. 2005..This study investigated the effect of dietary CLA supplementation (3g/day; 50:50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human (male and female) volunteers...
- Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humansSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
Am J Clin Nutr 80:614-20. 2004..However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear...
- Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolismRoger S McLeod
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
Am J Clin Nutr 79:1169S-1174S. 2004b>Conjugated linoleic acids (CLAs) are isomeric forms of the 18:2 fatty acid that contain conjugated sites of unsaturation. Although CLAs are minor components of the diet, they have many reported biological activities...
- Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathwayWen Ling Cheng
Departments of Nutrition and Life Sciences, Chung Shan Medical University, Number 110, Section 1, Chien Kuo North Road, Taichung 40203, Taiwan, Republic of China
J Agric Food Chem 52:71-8. 2004..7 macrophages and this inhibitory activity of CLA, at least in part, occurs through CLA modulating the NF-kappaB activation and therefore negatively regulating expression of inflammatory mediators...
- Conjugated linoleic acids: why the discrepancy between animal and human studies?Mélanie Plourde
Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Nutr Rev 66:415-21. 2008b>Conjugated linoleic acids (CLA) are positional and geometric isomers of linoleic acid. In animals, CLA consumption reduces body fat but results in humans are less conclusive...
- Conjugated linoleic acids reduce body fat in healthy postmenopausal womenMarianne Raff
Department of Human Nutrition, Faculty of Life, University of Copenhagen, Frederiksberg 1958, Denmark
J Nutr 139:1347-52. 2009Isomers of conjugated linoleic acids (CLA) reduce fat mass (FM) and increase insulin sensitivity in some, but not all, murine studies. In humans, this effect is still debatable...
- Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individualsEstelle V Lambert
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115 Newlands, 7725, South Africa
Br J Nutr 97:1001-11. 2007....
- Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cellsYukiko K Nakamura
Department of Nutrition and Environmental Sciences, University of Nevada, Reno, USA
Nutrition 25:800-11. 2009....
- Gender differences in the cardiac response to dietary conjugated linoleic acid isomersParamjit S Tappia
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
Can J Physiol Pharmacol 84:257-64. 2006..These results indicate that CLA isomers exert differential effects on heart function and suggest the need for a complete evaluation of the benefits, interactions, and potential side effects of each isomer...
- Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obeseJean Michel Gaullier
Link Medical Research AS, Kjeller, Norway
Br J Nutr 97:550-60. 2007..Adverse events did not differ between the groups. It is concluded that supplementation with CLA in healthy, overweight and obese adults decreases BFM in specific regions and is well tolerated...
- Concentrations of conjugated linoleic acids in neonatal blood in relationship to those in maternal bloodAndre Muller
Institut fur Biochemie und Lebensmittelchemie, Universitat Hamburg, Grindelallee 117, D 20146 Hamburg, Germany
Prostaglandins Leukot Essent Fatty Acids 76:213-9. 2007In this study, the proportions of conjugated linoleic acids (CLA) in total lipids of plasma, lipoproteins and erythrocytes from maternal blood and from venous cord blood of 20 pregnant women consuming conventional western diets after ..
- Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humansA Brianne Thrush
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
Appl Physiol Nutr Metab 32:372-82. 2007..In conclusion, mixed-isomer CLA supplementation in overweight non-diabetic humans results in the accumulation of CLA and ceramide in skeletal muscle, and decreases insulin sensitivity...
- Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteriaE Rosberg-Cody
Biotechnology, Dairy Products Research Centre, Teagasc, Moorepark, Fermoy, County Cork, Ireland
Appl Environ Microbiol 70:4635-41. 2004..The ability of some Bifidobacterium strains to produce CLA could be another human health-promoting property linked to members of the genus, given that this metabolite has demonstrated anticarcinogenic activity in vitro and in vivo...
- Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine productionSoonkyu Chung
Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 27402 6170, USA
J Biol Chem 280:38445-56. 2005....
- Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cellsHan Jin Cho
Department of Food Science and Nutrition, Hallym University, Chuncheon, 200 702, Korea
J Nutr 136:893-8. 2006..The induction of p21(CIP1/WAF1) may be one of the mechanisms by which t10c12 inhibits cell cycle progression in HT-29 cells...
- Production of (10E,12Z)-conjugated linoleic acid in yeast and tobacco seedsEllen Hornung
Georg August University Gottingen, Albrecht von Haller Institute for Plant Sciences, Department of Plant Biochemistry, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
Biochim Biophys Acta 1738:105-14. 2005..CLA was only detected in seeds in coPAI-transgenic plants. The amount of CLA detected in esterified fatty acids was up to 0.3%, in free fatty acids up to 15%...
- Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptinAtsuko Ohashi
Department of Clinical Pharmacology and Toxicology Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Tohbetsu, Hokkaido 061 029 3, Japan
J Nutr Sci Vitaminol (Tokyo) 50:416-21. 2004Dietary supplementation of conjugated linoleic acids (CLA) is known to have some beneficial effects such as anti-carcinogenic and anti-obesity effects in several animal species, while it also induces insulin resistance and fatty liver, ..
- Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in ratsHye Kyeong Kim
Food Function Research Division, Korea Food Research Institute, Seongnam 463 746, Korea
J Nutr Sci Vitaminol (Tokyo) 51:8-15. 2005..5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats...
- Conjugated linoleic acids promote human fat cell apoptosisP Fischer-Posovszky
Department of Pediatrics and Adolescent Medicine, University of Ulm, 89075 Ulm, Germany
Horm Metab Res 39:186-91. 2007b>Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Some isomers have been shown to reduce fat mass in animal and cell culture models...
- cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-AktDal Mi Hwang
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul 151 742, South Korea
Carcinogenesis 28:363-71. 2007..Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects...
- Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female miceMd Mizanur Rahman
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Nutr Biochem 18:467-74. 2007..In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors...
- Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged malesAnne Mullen
Nutrigenomics Research Group, Department of Clinical Medicine and Institute of Molecular Medicine, St James s Hospital, Dublin 8, Ireland
J Nutr Biochem 18:658-66. 2007..This study showed that CLA supplementation reduced PBMC IL-2 secretion from Con A-stimulated PBMC but lacked effect on other markers of the human inflammatory response...
- Conjugated linoleic acids exert similar actions on prostanoid release from aortic and coronary artery smooth muscle cellsRobert Ringseis
Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
Int J Vitam Nutr Res 76:281-9. 2006b>Conjugated linoleic acids (CLAs) are biologically active lipid compounds exerting anti-atherogenic actions in vivo without exact knowledge about the underlying mechanisms...
- Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjectsJulie Anne Nazare
Centre de Recherche en Nutrition Humaine de Lyon, Universite Claude Bernard Lyon 1, France
Br J Nutr 97:273-80. 2007..Moreover, changes in mRNA PPAR gamma and HSL in adipose tissue were recorded...
- Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1Do Y Lim
Division of Life Sciences, Hallym University, Chunchon, Korea
J Cell Physiol 205:107-13. 2005..These studies indicate that physiological concentrations of CLA inhibit growth of colon cancer cells with either wild-type or mutant p53, and may have therapeutic benefits in vivo...
- Safety of dietary conjugated linoleic acid (CLA) in a 12-weeks trial in healthy overweight Japanese male volunteersToshio Iwata
Research Laboratory, The Nisshin OilliO Group, Ltd, Tokyo, Japan
J Oleo Sci 56:517-25. 2007..These results indicate that CLA at a dose of 3.4 g/day is a safe dietary level in healthy Japanese populations in terms of the parameters examined...
- The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomised ratsO Kelly
Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland
Prostaglandins Leukot Essent Fatty Acids 71:295-301. 2004..001) lowered by CLA supplementation with 5 and 10, but not 2.5 g/kg diet in OVX rats. In conclusion, CLA supplementation appeared to reduce the rate of bone resorption in adult OVX rats...
- The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gainA C Watras
Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
Int J Obes (Lond) 31:481-7. 2007..Although research in humans has shown inconsistent results, most studies have been of insufficient duration or have utilized body composition methods that are less accurate than the currently accepted criterion...
- Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal womenRhonda A Brownbill
University of Connecticut, Division of Health and Human Development, School of Allied Health, 358 Mansfield Rd, Storrs, CT 06269, USA
J Am Coll Nutr 24:177-81. 2005..To determine if dietary conjugated linoleic acid (CLA) is associated with bone mineral density (BMD) of different skeletal sites in postmenopausal women...
- Conjugated linoleic acid reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin-resistant ratsAmy Noto
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Lipids 41:179-88. 2006..In summary, these results illustrate a strong relationship between the state of insulin resistance and liver lipid metabolism and suggest that CLA acts to favorably modify lipid metabolism in fa/fa Zucker rats...
- Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humansLeah D Whigham
Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 6188, USA
Am J Clin Nutr 85:1203-11. 2007..Conjugated linoleic acid (CLA) has been shown to be an effective supplement for reducing fat mass in animals, whereas results in humans have been inconsistent...
- Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human healthEric N Ponnampalam
Department of Food Science, RMIT University, Melbourne, Victoria 3001, Australia
Asia Pac J Clin Nutr 15:21-9. 2006..Data from the present study show that grain feeding decreases functional lipid components (long chain n-3 FA and CLA) in Australian beef regardless of meat cuts, while increasing total trans 18:1 and saturated FA levels...
- Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype BElke Naumann
Department of Human Biology, Maastricht University, Maastricht, The Netherlands
Atherosclerosis 188:167-74. 2006..Results of a pilot study suggested that cis-9, trans-11 conjugated linoleic acid (CLA) improved LDL phenotype in moderately overweight subjects with LDL phenotype B...
- Diets rich in conjugated linoleic acid and vaccenic acid have no effect on blood pressure and isobaric arterial elasticity in healthy young menMarianne Raff
Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Nutr 136:992-7. 2006..BP) and isobaric arterial elasticity (AE), as a measure of arterial health, of a commercial mixture of conjugated linoleic acids (CLA) and of milk fat produced through livestock feeding to have a high content of vaccenic acid (VA)...
- Effects of the individual isomers cis-9,trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype BJulian D Ramakers
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
Lipids 40:909-18. 2005..Inflammatory signatures in fasting, nonstimulated plasma as determined by an antibody array may indicate enhanced immune function by both CLA isomers...
- Rumenic acid significantly reduces plasma levels of LDL and small dense LDL cholesterol in hamsters fed a cholesterol- and lipid-enriched semi-purified dietMartial LeDoux
Laboratoire d Etudes et de Recherches sur la Qualité des Aliments et les Procédés agroalimentaires, Agence Francaise de Securite Sanitaire des Aliments, Maisons Alfort, France
Lipids 42:135-41. 2007b>Conjugated linoleic acids (CLAs) consist of a series of positional and geometrical isomers of linoleic acid. CLA have been reported to beneficially affect cardiovascular risk factors in animal models...
- Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytesJulian A Herrera
Department of Family Medicine, School of Medicine, Universidad del Valle, Cali, Colombia
Am J Hypertens 19:381-7. 2006....
- Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissueHélène Poirier
Physiologie de la Nutrition, ENSBANA, Unité Mixte de Recherche 5170 CESG Centre National de la Recherche Scientifique Institut National de la Recherche Agronomique Université de Bourgogne, Dijon, 21000 France
Diabetes 55:1634-41. 2006b>Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid...
- Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolismJ Salas-Salvado
Departament de Bioquimica i Biotecnologia, Facultat de Medicina i Ciencies de la Salut de Reus, Spain
Crit Rev Food Sci Nutr 46:479-88. 2006..Therefore, long-term randomized clinical trials, controlled with placebo, need to be made in large samples of patients to evaluate the efficacy and safety of CLA isomers before its indiscriminate use in human beings can be recommended...
- Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Fas(lpr) micePaolo Bergamo
Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
J Lipid Res 47:2382-91. 2006..In conclusion, enhanced GSH content and GCLC expression in CLA-treated mice suggest a novel biochemical mechanism underlying its immunomodulatory activity and the beneficial effects on murine SLE signs...
- Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cellsHan Jin Cho
Department of Food Science and Nutrition, Hallym University, 1 Okchon Dong, Chuncheon 200 702, Korea
World J Gastroenterol 11:5142-50. 2005..To examine whether trans-10,cis-12 CLA (t10c12) or cis-9,trans-11 CLA (c9t11) inhibits heregulin (HRG)-beta-stimulated cell growth and HRG-beta-ErbB3 signaling in HT-29 cells...
- Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese menSophie Desroches
Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
Am J Clin Nutr 82:309-19. 2005..Of the few studies that investigated the effects of CLA supplementation in humans, all used commercially formulated oral supplements made from a mixture of CLA isomers...
- Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrierAlessandra Ferramosca
Department of Sciences and Biological and Environmental Technologies, University of Lecce, 73100 Lecce, Italy
J Lipid Res 47:1994-2003. 2006..These data indicate that the CIC may play a role in the onset of hepatic steatosis in CLA-fed mice by supplying the carbon source for de novo fatty acid synthesis...
- Distribution of polyunsaturated fatty acids including conjugated linoleic acids in total and subcellular fractions from healthy and cancerous parts of human kidneysKristina Hoffmann
Institute of Biochemistry and Food Chemistry, University of Hamburg, 20146 Hamburg, Germany
Lipids 40:309-15. 2005..Further understanding of the cause and/or consequence of the difference in FA metabolism may lead to a better understanding of RCC...
- Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cellsStephanie C Degner
Department of Nutritional Sciences, Arizona Cancer Center, The University of Arizona, Tucson, AZ 85721, USA
J Nutr 136:421-7. 2006..Collectively, these results suggest that CLA represses AP-1-mediated activation of COX-2 transcription...
- Conjugated linoleic acidsBill Campbell
Exercise and Performance Nutrition Laboratory, Department of Physical Education and Exercise Science, University of South Florida, FL, USA
Curr Sports Med Rep 7:237-41. 2008..Additionally, recent investigations into the safety of CLA supplementation also are reviewed...
- Conjugated linoleic acids and CLA-containing phospholipids inhibit NO formation in aortic endothelial cellsKimberly J Jenko
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, 2300 Eye Street, N W, Washington, DC 20037, USA
Lipids 43:335-42. 2008....
- Conjugated linoleic acid isomers and cancerNirvair S Kelley
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616 8643, USA
J Nutr 137:2599-607. 2007..Additional studies with purified isomers are needed to establish the health benefit and risk ratios of each isomer in humans...
- Dose response of milk fat to intravenous administration of the trans-10, cis-12 isomer of conjugated linoleic acidS Viswanadha
Department of Animal and Veterinary Science, University of Idaho, Moscow 83844, USA
J Dairy Sci 86:3229-36. 2003..Intravenous infusion of the trans-10, cis-12 isomer of CLA depressed milk fat in a linear manner over the range of infusion studied and, therefore, is an alternative to abomasal infusion...
- Conjugated linoleic acid and atherosclerosis: studies in animal modelsPatricia L Mitchell
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
Biochem Cell Biol 86:293-301. 2008b>Conjugated linoleic acids (CLA) are isomeric forms of linoleic acid (LA) containing two conjugated sites of unsaturation...
- Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) ratsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840 8502, Japan
Biochem Biophys Res Commun 310:562-6. 2003..We speculate that the increase alleviates hyperinsulinemia and prevents the onset of hypertension in CLA-fed ZDF rats...
- Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cellsMichael Q Kemp
Nutritional Sciences Interdisciplinary Program, Laboratory of Mammary Gland Biology, Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85718, USA
J Nutr 133:3670-7. 2003....
- Conjugated linoleic acid supplementation modified the body composition and serum leptin levels in weaning ratsAdriana Prais Botelho
Laboratory of Lipids, Department of Food and Nutrition, College of Food Engineering, State University of Campinas, Brasil
Arch Latinoam Nutr 58:156-63. 2008..05). Supplementation with conjugated linoleic acid in the concentration of 2% of mean daily feed consumption was able to change body composition of rats after 42 days of experimentation...
- Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondriaAlejandro Palacios
Catedra de Bioquimica, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina
Mol Cell Biochem 250:107-13. 2003..The simultaneous analysis of peroxidizability index, chemiluminescence and fatty acid composition demonstrated that CLA is more effective than vitamin A protecting microsomes or mitochondria from peroxidative damage...
- Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humansJean Michel Gaullier
Scandinavian Clinical Research AS, Kjeller, Norway
Am J Clin Nutr 79:1118-25. 2004..Short-term trials showed that conjugated linoleic acid (CLA) may reduce body fat mass (BFM) and increase lean body mass (LBM), but the long-term effect of CLA was not examined...
- Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent modelsCarla G Taylor
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
Am J Clin Nutr 79:1164S-1168S. 2004..The different responses of normal compared with insulin-resistant obese rodents suggest that interactions of CLA isomers with the cellular components that contribute to development of metabolic syndrome require further investigation...
- Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal productsJohn K G Kramer
Food Research Program, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
Am J Clin Nutr 79:1137S-1145S. 2004..These improved techniques are used to evaluate the CLA profile in pork products from pigs fed different commercial CLA mixtures...
- Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in ratsHope Weiler
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Clin Nutr 79:1186S-1189S. 2004..Feeding conjugated linoleic acid (CLA) is reported to reduce prostaglandin E(2) synthesis, which is required for parathyroid hormone (PTH) release...
- Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic AcidsPapasani V Subbaiah; Fiscal Year: 2013..provided by applicant): The major goal of this proposal is to investigate the mechanism of action of conjugated linoleic acids (CLA), the naturally occurring isomers of linoleic acid (LA), which have several unique physicochemical ..
- Mechanisms of NaCl Absorption in the Human ColonPradeep K Dudeja; Fiscal Year: 2013..evidence for the regulation of DRA expression by both HNFs and their activators dexamenthasone (DEX) and conjugated linoleic acids (CLAs), as well as miRNAs...
- Physiological Significance of Conjugated Double Bonds in Membrane LipidsPapasani Subbaiah; Fiscal Year: 2009..are generally detrimental to human health, a new class of naturally occurring trans fatty acids, called conjugated linoleic acids (CLA), which are found in dairy products and meat, have been shown to have several health benefits...
- Mechanisms of Immune Modulation by Abscisic AcidJosep Bassaganya Riera; Fiscal Year: 2010..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
- ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISMPapasani Subbaiah; Fiscal Year: 2008..These studies will provide novel insights into the physiological role of this important phospholipid, and could possibly open up novel therapeutic targets against inflammation and atherosclerosis. ..
- TNF Modulation of Mammary ProliferationMARGOT IP; Fiscal Year: 2007..Thus, as part of this aim, the efficacy of anti-TNF therapy vs local TNF therapy against mammary tumors will be compared. ..
- LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIESPapasani Subbaiah; Fiscal Year: 2002..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
- MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLINRoderick Dashwood; Fiscal Year: 2008..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
- Molecular biomarkers of selenium chemopreventionClement Ip; Fiscal Year: 2006..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
- BIOCHEMICAL CHARACTERIZATION OF PPARJOHN VANDEN HEUVEL; Fiscal Year: 2008..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..
- CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLESClement Ip; Fiscal Year: 2003..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
- ALCOHOL INDUCED IMMUNOMODULATION--RETROVIRAL CARDIOPATHRONALD WATSON; Fiscal Year: 2003..Such studies could provide the basis for their application to reduce heart disease in alcohol-abusing, HIV-infected patients. ..
- NONINVASIVE MEASUREMENT OF ENERGY EXPENDITURE IN HUMANSDale Schoeller; Fiscal Year: 2007..These studies will provide important guidelines for the prescription of exercise for the prevention and treatment of obesity. ..
- Phytoestrogens and breast cancer riskSusan McCann; Fiscal Year: 2006..These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer. ..
- MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACIDClement Ip; Fiscal Year: 2007..abstract_text> ..
- Selenium molecular signaling in human prostate cancerClement Ip; Fiscal Year: 2007..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
- IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGYRONALD WATSON; Fiscal Year: 2001..The treatments that found to prevent cytokine dysregulation and cardiotoxicitiy in retrovirally infected mice will then be applicable to reducing heart disease in HIV infected patients (End of Abstract) ..
- Gene-Nutrient Interactions and Breast CancerSUSAN STECK; Fiscal Year: 2007..abstract_text> ..
- SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDSROBERT CHAPKIN; Fiscal Year: 2003..g., rheumatoid arthritis), without compromising host defenses. ..
- ISOTOPE RATIO MASS SPECTROMETERDale Schoeller; Fiscal Year: 2006..In addition, this new instrument will provide new capacity in the form of the solids combustion inlet. This expands our potential users group in the area of development of dietary biomarkers. [unreadable] [unreadable]..