ecdysteroids

Summary

Summary: Steroids that bring about MOLTING or ecdysis in insects. Ecdysteroids include the endogenous insect hormones (ECDYSONE and ECDYSTERONE) and the insect-molting hormones found in plants, the phytoecdysteroids. Phytoecdysteroids are natural insecticides.

Top Publications

  1. ncbi Isolation, characterization and developmental expression of the ecdysteroid-induced E75 gene of the wax moth Galleria mellonella
    M Jindra
    Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice
    Eur J Biochem 221:665-75. 1994
  2. ncbi Comparative action of RH-0345 and pyriproxyfen on molting hormone production and protein analysis in mealworm pupae
    N Aribi
    , , 23000 Annaba,
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 66:445-54. 2001
  3. ncbi Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression
    Adriana Mendes do Nascimento
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida Bandeirantes 3 900, Ribeirao Preto, 14040 901 SP, Brazil
    Insect Biochem Mol Biol 34:415-24. 2004
  4. ncbi Studies on the Black Box: incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta
    James T Warren
    Department of Biology, Campus Box 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Insect Biochem Mol Biol 39:677-87. 2009
  5. pmc Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation
    Annekatrin König
    Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    EMBO J 30:1549-62. 2011
  6. ncbi molting defective is required for ecdysone biosynthesis
    Dagmar Neubueser
    European Molecular Biology Laboratory, Heidelberg, Germany
    Dev Biol 280:362-72. 2005
  7. ncbi Conversion of 3-oxo steroids into ecdysteroids triggers molting and expression of 20E-inducible genes in Drosophila melanogaster
    Hajime Ono
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 421:561-6. 2012
  8. ncbi Control and biochemical nature of the ecdysteroidogenic pathway
    Lawrence I Gilbert
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Annu Rev Entomol 47:883-916. 2002
  9. pmc Drosophila female precopulatory behavior is modulated by ecdysteroids
    G K Ganter
    Department of Biology, College of Arts and Sciences, University of New England, Biddeford, ME 04005, USA
    J Insect Physiol 58:413-9. 2012
  10. ncbi TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404, ROC
    Insect Biochem Mol Biol 42:296-303. 2012

Research Grants

  1. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
  2. Context-specific Functions of CDK8
    Jun Yuan Ji; Fiscal Year: 2013
  3. Integrating physiological and genetic mechanisms of body size regulation
    Viviane Callier; Fiscal Year: 2013
  4. LIGHT-ACTIVATED GENE EXPRESSION IN SINGLE CELLS WITHIN TISSUE
    Robert H Singer; Fiscal Year: 2011
  5. Ecdysteroid Signaling in Filarial Parasites
    Thomas R Unnasch; Fiscal Year: 2013
  6. CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOS
    PETER STEPONKUS; Fiscal Year: 1993
  7. MOLECULAR BASIS OF ECDYSTEROID ACTION IN THE MOSQUITO
    ALEXANDER SIMEON RAIKHEL; Fiscal Year: 2013
  8. REPRODUCTION IN TICKS AND MITES
    James Oliver; Fiscal Year: 1993
  9. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
  10. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991

Detail Information

Publications237 found, 100 shown here

  1. ncbi Isolation, characterization and developmental expression of the ecdysteroid-induced E75 gene of the wax moth Galleria mellonella
    M Jindra
    Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice
    Eur J Biochem 221:665-75. 1994
    ..In isolated abdomens of final instar larvae, GmE75A mRNA was induced by 20-hydroxyecdysone within 20 min of the injection; the mRNA levels were maximal at 1 h and declined by 3 h following the treatment...
  2. ncbi Comparative action of RH-0345 and pyriproxyfen on molting hormone production and protein analysis in mealworm pupae
    N Aribi
    , , 23000 Annaba,
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 66:445-54. 2001
    ..Changes in protein concentrations showed that pyriproxyfen suppressed the second peak and the values recorded were either significantly increased at day 2 and 3, either reduced from day 4...
  3. ncbi Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression
    Adriana Mendes do Nascimento
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida Bandeirantes 3 900, Ribeirao Preto, 14040 901 SP, Brazil
    Insect Biochem Mol Biol 34:415-24. 2004
    ..The negative regulation of AmTRF by ecdysteroids deduced from the developmental expression profile was confirmed by experimental treatment of spinning-stage ..
  4. ncbi Studies on the Black Box: incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta
    James T Warren
    Department of Biology, Campus Box 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Insect Biochem Mol Biol 39:677-87. 2009
    ..In this manner, 3-oxo-7dC is quickly and efficiently incorporated into ecdysteroids by adult male and female Drosophila raised on a diet containing the PSKB ketals and in prothoracic glands of ..
  5. pmc Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation
    Annekatrin König
    Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    EMBO J 30:1549-62. 2011
    ..Here, we show that ecdysteroids regulate progression through the early steps of germ cell lineage...
  6. ncbi molting defective is required for ecdysone biosynthesis
    Dagmar Neubueser
    European Molecular Biology Laboratory, Heidelberg, Germany
    Dev Biol 280:362-72. 2005
    ..Here, we report identification of one such gene, which we call molting defective, on the basis of its lethal phenotype. molting defective encodes a nuclear zinc finger protein required for ecdysone biosynthesis...
  7. ncbi Conversion of 3-oxo steroids into ecdysteroids triggers molting and expression of 20E-inducible genes in Drosophila melanogaster
    Hajime Ono
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 421:561-6. 2012
    b>Ecdysteroids, steroid hormones in insects, coordinate major developmental transitions. During postembryonic development, ecdysone is biosynthesized from dietary cholesterol in the prothoracic gland (PG)...
  8. ncbi Control and biochemical nature of the ecdysteroidogenic pathway
    Lawrence I Gilbert
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Annu Rev Entomol 47:883-916. 2002
    Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own...
  9. pmc Drosophila female precopulatory behavior is modulated by ecdysteroids
    G K Ganter
    Department of Biology, College of Arts and Sciences, University of New England, Biddeford, ME 04005, USA
    J Insect Physiol 58:413-9. 2012
    ..These results support the hypothesis that ecdysteroids modulate female sexual behavior, perhaps acting as a regulator of sexual motivation, and as a component ..
  10. ncbi TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404, ROC
    Insect Biochem Mol Biol 42:296-303. 2012
    ..These results suggest that PTTH/PI3K/TOR/4E-BP (S6K) signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in B. mori...
  11. ncbi The regulation of expression of insect cuticle protein genes
    J P Charles
    UMR CNRS 5548 Développement Communication Chimique des Insectes DCCI, Universite de Bourgogne, Faculte des Sciences Gabriel, 6, bd Gabriel 21000 Dijon, France
    Insect Biochem Mol Biol 40:205-13. 2010
    ..genes encoding cuticle proteins are therefore good models to study the molecular mechanisms of signalling by ecdysteroids and juvenile hormones, which regulate molting and metamorphosis in insects...
  12. ncbi Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti
    Douglas H Sieglaff
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 35:471-90. 2005
    ..Expression of these genes likely supports the low level of ecdysteroids produced in vitro (7-10 pg /tissue/6 h) by tissues other than ovaries...
  13. ncbi In vitro and in vivo stimulation of extracellular signal-regulated kinase (ERK) by the prothoracicotropic hormone in prothoracic gland cells and its developmental regulation in the silkworm, Bombyx mori
    Ju Ling Lin
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    J Insect Physiol 53:622-31. 2007
    ..These results suggest that development-specific changes in ERK phosphorylation may play a role in PTTH stimulation of ecdysteroidogenesis...
  14. ncbi Developmental characterization, function and regulation of a Laccase2 encoding gene in the honey bee, Apis mellifera (Hymenoptera, Apinae)
    Moysés Elias-Neto
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14040 901 Ribeirao Preto, SP, Brazil
    Insect Biochem Mol Biol 40:241-51. 2010
    ..Taken together, these results indicate that Amlac2 expression is controlled by ecdysteroids and has a critical role in the differentiation of the adult exoskeleton of honey bees.
  15. pmc The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis
    Paul Badenhorst
    Laboratory of Molecular Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland 20814, USA
    Genes Dev 19:2540-5. 2005
    ..Moreover, purified NURF binds EcR in an ecdysone-dependent manner, suggesting it is a direct effector of nuclear receptor activity. The conservation of NURF in mammals has broad implications for steroid signaling...
  16. ncbi Control of ecdysteroidogenesis in prothoracic glands of insects: a review
    Elisabeth Marchal
    Department of Animal Physiology and Neurobiology, K U Leuven, Naamsestraat 59, 3000 Leuven, Belgium
    Peptides 31:506-19. 2010
    ..The complex secretory pattern of ecdysteroids as observed in vivo is the result of the delicate balance and interplay between these ecdysiotropic and ..
  17. ncbi Peripheral regulation by ecdysteroids of olfactory responsiveness in male Egyptian cotton leaf worms, Spodoptera littoralis
    Laetitia Bigot
    UMR 1272 Physiologie de l Insecte, Signalisation et Communication, Universite Pierre et Marie Curie, Paris VI, 7 quai Saint Bernard, F 75005 Paris, France
    Insect Biochem Mol Biol 42:22-31. 2012
    ..Taken together, these molecular, electrophysiological, and behavioral results suggest a hormonal regulation of the peripheral olfactory processing in S. littoralis...
  18. pmc Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells
    Jonathan Gorelick-Feldman
    Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Steroids 75:632-7. 2010
    ..The effect was inhibited by a G-protein coupled receptor (GPCR) inhibitor, a phospholipase C (PLC) inhibitor, and a phosphoinositide kinase-3 (PI3K) inhibitor...
  19. ncbi C-29 ecdysteroids from Ajuga reptans var. reptans
    Attila Ványolós
    Department of Pharmacognosy, University of Szeged, Eötvös utca 6, H 6720 Szeged, Hungary
    J Nat Prod 72:929-32. 2009
    ..reptans resulted in the isolation of three new ecdysteroids, named reptanslactone A (2), reptanslactone B (3), and sendreisterone (5), and the known 24-..
  20. ncbi Insulin stimulates ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, Taichung, Taiwan, ROC
    Insect Biochem Mol Biol 39:171-9. 2009
    ..These results suggest that in silkworm prothoracic glands, in addition to the PTTH and an autocrine factor, ecdysteroidogenesis is also stimulated by insulin during development...
  21. ncbi The metabolism of 20-hydroxyecdysone in mice: relevance to pharmacological effects and gene switch applications of ecdysteroids
    S Kumpun
    UPMC, Univ Paris, Laboratoire BIOSIPE, Paris 05, France
    J Steroid Biochem Mol Biol 126:1-9. 2011
    b>Ecdysteroids exert many pharmacological effects in mammals (including humans), most of which appear beneficial, but their mechanism of action is far from understood...
  22. ncbi New insights into the roles of juvenile hormone and ecdysteroids in honey bee reproduction
    Jakob Wegener
    Institute for Bee Research, Hohen Neuendorf, Germany
    J Insect Physiol 59:655-61. 2013
    In workers of the Western honeybee, Apis mellifera, juvenile hormone (JH) and ecdysteroids regulate many aspects of age polyphenism...
  23. ncbi A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Cell 17:885-91. 2009
    ..These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth...
  24. ncbi Ecdysteroids during early embryonic development in silkworm Bombyx mori: metabolism and functions
    Haruyuki Sonobe
    Department of Biology, Faculty of Science and Engineering, Konan University, Kobe, Japan
    Zoolog Sci 21:503-16. 2004
    ..that eggs of insects, including those of the silkworm Bombyx mori, contain various molecular species of ecdysteroids in free and conjugated forms. In B. mori eggs, 20-hydroxyecdysone (20E) is a physiologically active molecule...
  25. ncbi PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca(2+)/calmodulin and receptor tyrosine kinase
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    J Insect Physiol 56:93-101. 2010
    ....
  26. ncbi Biological activity of two juvenoids and two ecdysteroids against three stored product insects
    M Kostyukovsky
    Department of Stored Products, ARO, The Volcani Center, 50250, Bet Dagan, Israel
    Insect Biochem Mol Biol 30:891-7. 2000
    ..The percentage reductions of F(1) adults for S- and R-strains of T. castaneum at a concentration of 20 ppm were 80 and 99%, respectively...
  27. pmc Drosophila male courtship behavior is modulated by ecdysteroids
    G K Ganter
    Department of Biology, College of Arts and Sciences, University of New England, Biddeford, ME 04005, USA
    J Insect Physiol 57:1179-84. 2011
    ..These observations support the hypothesis that reduced levels of ecdysteroids increase the probability that male fruit flies will display courtship behaviors to male stimuli.
  28. ncbi Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the 'Black Box' of the ecdysteroid biosynthesis pathway
    Ryusuke Niwa
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    Development 137:1991-9. 2010
    ..Furthermore, the phenotypes caused by the loss of function of these genes are restored by the application of ecdysteroids and their precursor 5beta-ketodiol, but not by cholesterol or 7-dehydrocholesterol...
  29. pmc Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster
    James T Warren
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 99:11043-8. 2002
    ..Expression of dib and sad continues to be localized in this endocrine compartment during larval development, being maximal in both the late second and third instar larvae, about the time of the premolt peaks in the ecdysteroid titer...
  30. ncbi Developmental profile of the changes in the prothoracicotropic hormone titer in hemolymph of the silkworm Bombyx mori: correlation with ecdysteroid secretion
    A Mizoguchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, 464 8602, Nagoya, Japan
    Insect Biochem Mol Biol 31:349-58. 2001
    ..However, some unexpected aspects of PTTH dynamics in hemolymph have also been disclosed. Based on these observations, the significance of PTTH secretion in the control of insect development is discussed...
  31. ncbi Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary
    David S Richard
    Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA
    J Insect Physiol 51:455-64. 2005
    ..Homozygous chico(1) females exhibit approximately wild-type rates of JH biosynthesis, ovarian release of ecdysteroids and haemolymph ecdysteroid levels, suggesting that these two major hormone systems play no role in producing ..
  32. ncbi Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    Insect Biochem Mol Biol 41:197-202. 2011
    ..mori prothoracic glands between insulin and PTTH signaling, which may play a critical role in precisely regulated ecdysteroidogenesis during development...
  33. ncbi Ecdysteroids, juvenile hormone and insect neuropeptides: Recent successes and remaining major challenges
    Arnold De Loof
    Zoological Institute of the Katholieke Universiteit Leuven, Naamsestraat 59, 3000 Leuven, Belgium
    Gen Comp Endocrinol 155:3-13. 2008
    ..Substantial progress has been realized in identifying the Halloween genes, a membrane receptor(s) for ecdysteroids, a nuclear receptor for methylfarnesoate, and dozens of GPCRs for insect neuropeptides...
  34. ncbi Ecdysteroids in stress responsive and nonresponsive Drosophila virilis lines under stress conditions
    A Hirashima
    Department of Applied Genetics and Pest Management, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:2657-62. 2000
    ..A role of the ecdysteroids in the control of reproduction of D. virilis under stress is discussed.
  35. ncbi Ecdysteroids during the third larval instar in 1(3)ecd-1ts, a temperature-sensitive mutant of Drosophila melanogaster
    P Berreur
    Gen Comp Endocrinol 54:76-84. 1984
    ..b>Ecdysteroids were studied during the third larval instar by HPLC analysis and radioimmunoassays...
  36. ncbi The mutation without children(rgl) causes ecdysteroid deficiency in third-instar larvae of Drosophila melanogaster
    J Wismar
    Institut fur Genetik, Johannes Gutenberg Universitat, Saarstrasse 21a, Mainz, 55099, Germany
    Dev Biol 226:1-17. 2000
    ..The woc protein shows considerable homology to human proteins which have been implicated in both mental retardation and a leukemia/lymphoma syndrome...
  37. ncbi Ecdysteroids from Vitex species: distribution and compilation of their 13C-NMR spectral data
    José G Sena Filho
    Universidade Federal da Paraiba, Laboratorio de Tecnologia Farmaceutica, Caixa Postal 5009, 58051 970, Joao Pessoa, PB, Brazil
    Chem Biodivers 5:707-13. 2008
    Iridoids and ecdysteroids are found in some genera of the family Verbenaceae...
  38. ncbi The RXR ortholog USP suppresses early metamorphic processes in Drosophila in the absence of ecdysteroids
    M Schubiger
    Department of Zoology, University of Washington, Seattle WA 98195, USA
    Development 127:1151-9. 2000
    ..Our observations suggest that silencing by the unliganded EcR/USP receptor and the subsequent release of silencing by moderate steroid levels may play an important role in coordinating early phases of steroid driven development...
  39. ncbi Ecdysteroids govern two phases of eye development during metamorphosis of the moth, Manduca sexta
    D T Champlin
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 125:2009-18. 1998
    The eye primordium of the moth, Manduca sexta, shows two different developmental responses to ecdysteroids depending on the concentration to which it is exposed...
  40. ncbi Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity
    Xueyan Mu
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633 USA
    Gen Comp Endocrinol 129:127-33. 2002
    ..These results demonstrated that (1). ecdysteroids regulate critical processes in daphnid embryo development, (2)...
  41. ncbi Phytoecdysteroids and vitamin D analogues--similarities in structure and mode of action
    Noemi Toth
    Department of Biochemistry, University of Szeged, H 6720 Szeged, Szeged, Hungary
    Curr Med Chem 17:1974-94. 2010
    ..The ecdysteroids exert several beneficial effects on mammals, from which the most cited and deeply examined one is the increase ..
  42. ncbi Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals
    Laurence Dinan
    Department of Biological Sciences, University of Exeter, Exeter, Devon EX4 4PS, UK
    J Endocrinol 191:1-8. 2006
    ..of this short review is to summarise findings on the occurrence, metabolism and pharmacological effects of ecdysteroids in mammalian systems and to draw attention to their potential applications, particularly in gene-switch ..
  43. ncbi Control of larval-pupal-adult molt in the moth Sesamia nonagrioides by juvenile hormone and ecdysteroids
    Meritxell Pérez-Hedo
    Centre R D de Lleida UdL IRTA, Rovira Roure 191, 25198 Lleida, Spain
    J Insect Physiol 57:602-7. 2011
    ..that the prothoracic glands (PGs) and the corpora allata (CA) of debrained larvae continue to produce ecdysteroids and JHs, respectively...
  44. ncbi Activation of an extracellular signal-regulated kinase (ERK) by the insect prothoracicotropic hormone
    R Rybczynski
    Department of Biology, Coker Hall CB 3280, University of North Carolina at Chapel Hill, 27599 3280, USA
    Mol Cell Endocrinol 184:1-11. 2001
    ..The predominant source of ecdysteroids in pre-adult insects is the prothoracic gland, which is under the acute control of the neuropeptide hormone ..
  45. ncbi Phytoecdysteroids: biological effects, application in agriculture and complementary medicine (as presented at the 14-th Ecdysone Workshop, July, 2000, Rapperswil, Switzerland)
    Y Kholodova
    Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv
    Ukr Biokhim Zh 73:21-9. 2001
    Serratula coronata and Serratula inermis (fam. Asteraceae) have been chosen as the most perspective sources for ecdysteroids from the flora of Ukraine. Ecdysterone was the major component in both species (approximately 2%)...
  46. ncbi Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata
    Yu Jun Cai
    National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China
    Can J Physiol Pharmacol 80:1187-94. 2002
    The antioxidative and free radical scavenging effects of four ecdysteroids, 20-hydroxyecdysone (E1), 25-deoxy-11,20-dihydroxyecdysone (E2), 24-(2-hydroxyethyl)-20-hydroxyecdysone (E3), and 20-hydroxyecdysone-20,22-monoacetonide (E4), ..
  47. pmc Practical uses for ecdysteroids in mammals including humans: an update
    R Lafont
    Universite Pierre et Marie Curie, Institut de Biologie Intégrative, Laboratoire d Endocrinologie Moléculaire et Evolution, 7 quai Saint Bernard, Case Courrier No 29, 75252 Paris Cedex 05, France
    J Insect Sci 3:7. 2003
    b>Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements...
  48. ncbi Ecdysteroids from Polypodium vulgare L
    Andras Simon
    Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt Gellert ter 4, H 1111 Budapest, Hungary
    Steroids 76:1419-24. 2011
    ..The structures of compounds were elucidated by spectroscopic methods including 1D and 2D NMR measurements. The (1)H and (13)C NMR assignments of compounds 1, 6, 9 and 10 are included...
  49. ncbi Ecdysteroids from Serratula wolffii roots
    Erika Liktor-Busa
    Department of Pharmacognosy, University of Szeged, Szeged, Eötvös utca 6, H 6720, Hungary
    J Nat Prod 70:884-6. 2007
    Two new natural ecdysteroids, 20,22-didehydrotaxisterone (1) and 1-hydroxy-20,22-didehydrotaxisterone (2), were isolated from the roots of Serratula wolffii...
  50. ncbi Differential incorporation of cholesterol and cholesterol derivatives into ecdysteroids by the larval ring glands and adult ovaries of Drosophila melanogaster: a putative explanation for the l(3)ecd1 mutation
    J T Warren
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Insect Biochem Mol Biol 26:931-43. 1996
    ..Emulsified 7d25C was incorporated directly into ecdysteroids by these tissue preparations at a much greater rate than was 7d25C made in situ from 25C...
  51. ncbi Quantification of ecdysteroids by immunoassay: comparison of enzyme immunoassay and radioimmunoassay
    N Pascual
    Department of Agrobiology, , Barcelona, Spain
    Z Naturforsch C 50:862-7. 1995
    The performance of enzyme immunoassay (EIA) and radioimmunoassay (RIA) in the quantitative analysis of ecdysteroids was compared...
  52. ncbi Comparison of ecdysteroid concentration in different morphs of aphids
    L A Polgár
    Department of Zoology, Hungarian Academy of Sciences, Budapest, Hungary
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 115:179-83. 1996
    The amounts of ecdysteroids were determined in different morphs of holocyclic monoecious aphids (Acyrthosiphon pisum Harris, Dysaphis devecta Walk., Lachnus roboris L., Schizolachnus pineti F...
  53. ncbi Ecdysteroids from the Antarctic tunicate Synoicum adareanum
    Yoshinari Miyata
    Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery, and Delivery, University of South Florida, Tampa, FL 33620, USA
    J Nat Prod 70:1859-64. 2007
    Five new ecdysteroids, hyousterones A-D (2-5) and abeohyousterone (6), have been isolated from the Antarctic tunicate Synoicum adareanum along with the known ecdysteroid diaulusterol B (1)...
  54. ncbi A cuticle protein gene in the honeybee: expression during development and in relation to the ecdysteroid titer
    Michelle P M Soares
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14040 901 Ribeirao Preto, SP, Brazil
    Insect Biochem Mol Biol 37:1272-82. 2007
    ..Such developmental pattern suggested that AmelCPR14 gene might be regulated by the titer of ecdysteroids. We confirmed this hypothesis using different experimental strategies...
  55. ncbi Expression of ecdysteroids and cytochrome P450 enzymes during lipid turnover and reproduction in Calanus finmarchicus (Crustacea: Copepoda)
    Bjørn Henrik Hansen
    SINTEF Materials and Chemistry, Marine Environmental Technology, N 7465 Trondheim, Norway
    Gen Comp Endocrinol 158:115-21. 2008
    ..we observed that ecdysteroid concentrations were higher in females with large egg sacs, suggesting that ecdysteroids may be involved in egg maturation and reproduction...
  56. ncbi 26-Hydroxylated ecdysteroids from Silene viridiflora
    Noemi Toth
    Department of Pharmacognosy, University of Szeged, Szeged, Eötvös utca 6, H 6720, Hungary
    J Nat Prod 71:1461-3. 2008
    ....
  57. ncbi Effects of atrazine and endosulfan sulphate on the ecdysteroid system of Daphnia magna
    P Palma
    Departamento de Ciências do Ambiente, Escola Superior Agrária de Beja, Beja 7800 295, Portugal
    Chemosphere 74:676-81. 2009
    ..if the toxic effects observed with the isolated pesticides were promoted or not by the disruption of the ecdysteroids system of the crustacean, by co-administrating of them with 20-hydroxyecdysone hormone...
  58. ncbi Ecdysteroids regulate secretory competence in Inka cells
    T G Kingan
    Department of Entomology University of California, Riverside, CA 92521, USA
    J Exp Biol 203:3011-8. 2000
    Ecdysis, or molting behavior, in insects requires the sequential action of high levels of ecdysteroids, which induce accumulation of ecdysis-triggering hormone (ETH) in Inka cells, followed by low levels of ecdysteroids, permissive for ..
  59. ncbi Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities
    L Dinan
    Department of Biological Sciences, University of Exeter, Devon, UK
    Cell Mol Life Sci 58:321-42. 2001
    ..Possible reasons for the prevalence of antagonists and for the low potency of the majority of them are discussed...
  60. ncbi Stage dependent influences of polydnaviruses and the parasitoid larva on host ecdysteroids
    Rita Pfister-Wilhelm
    Institute of Cell Biology, University of Berne, Berne, Switzerland
    J Insect Physiol 55:707-15. 2009
    ..e. immediately before egression of the parasitoid. In vitro experiments showed that late 2nd instar parasitoids release ecdysteroids and are thus very likely responsible for the rise in host ecdysteroids.
  61. ncbi A new ecdysteroid with unique 9beta-OH and four other ecdysteroids from Silene italica ssp. nemoralis
    Andras Simon
    Institute for General and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Szt Gellert ter 4, H 1111 Hungary
    Steroids 69:389-94. 2004
    ..nemoralis. Compound 1 is the C-9 epimer of the known 9alpha,20-dihydroxyecdysone (6) and represents a peculiar steroid skeleton. The structures of the compounds were elucidated by 1D and 2D NMR, IR and MS spectroscopy...
  62. ncbi Regulation of 20-hydroxyecdysone on the larval pigmentation and the expression of melanin synthesis enzymes and yellow gene of the swallowtail butterfly, Papilio xuthus
    Ryo Futahashi
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 501, Kashiwa, Chiba 277 8562, Japan
    Insect Biochem Mol Biol 37:855-64. 2007
    ..These results indicate that cuticular pigmentation is controlled by the exposure to 20E and its removal...
  63. ncbi [Ecdysteroids of Silene italica ssp. nemoralis, novel approaches of ecdysteroid therapy]
    Maria Bathori
    Szegedi Tudomanyegyetem, Farmakognóziai Intézet, Szeged, Eötvös u 6 6720
    Acta Pharm Hung 74:131-41. 2004
    b>Ecdysteroids are known as insect moulting hormones. They have the basic steroid structure, although their physiological effects on mammalians do not show the thymolytic and androgenic side effects of vertebrate type steroid hormones...
  64. ncbi Protein kinase C modulates ecdysteroidogenesis in the prothoracic gland of the tobacco hornworm, Manduca sexta
    Robert Rybczynski
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Mol Cell Endocrinol 251:78-87. 2006
    The prothoracic gland is the primary source of ecdysteroid hormones in the immature insect. Ecdysteroids coordinate gene expression necessary for growth, molting and metamorphosis...
  65. ncbi 4D-QSAR analysis of a set of ecdysteroids and a comparison to CoMFA modeling
    M Ravi
    Laboratory of Molecular Modeling and Design (M/C-781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612-7231, USA
    J Chem Inf Comput Sci 41:1587-604. 2001
    ..A training set of 71 ecdysteroids, for which the -log(EC(50)) potencies in the ecdysteroid-responsive B(II) cell line were measured, was used to ..
  66. ncbi Phytoecdysteroids effects on mammalians, isolation and analysis
    Maria Bathori
    Department of Pharmacognosy, University of Szeged, Eötvös utca 6, H 6720 Szeged, Hungary
    Mini Rev Med Chem 2:285-93. 2002
    b>Ecdysteroids are known insect moulting hormones, regulating the insects' metamorphosis. At the same time, ecdysteroids reveal beneficial effects on humans and animals alike...
  67. ncbi Endocrine changes associated with the starvation-induced premature metamorphosis in the yellow-spotted longicorn beetle, Psacothea hilaris
    Florence N Munyiri
    Laboratory of Applied Entomology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Gen Comp Endocrinol 144:150-5. 2005
    ..Altogether, these results suggest that starvation induces a rapid decline in the JH titer, and this cues the early occurrence of a small ecdysteroid peak that commits larvae to early metamorphosis...
  68. ncbi [Overexpression of a novel gene toothrin in Drosophila]
    O B Simonova
    Genetika 41:196-202. 2005
    ....
  69. ncbi Effects of RH-5992 on ecdysteroidogenesis of the prothoracic glands during the fourth larval instar of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, Taichung, Taiwan, ROC
    Arch Insect Biochem Physiol 68:197-205. 2008
    ..These results indicated that both PTTH-cAMP signaling and PTTH-ERK signaling may not be involved in short-term inhibitory regulation by RH-5992...
  70. ncbi Temporal changes in DNA synthesis of prothoracic gland cells during larval development and their correlation with ecdysteroidogenic activity in the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404 19, R O C
    J Exp Zool A Comp Exp Biol 303:249-58. 2005
    ..It was found that both growth factors and the responsiveness of the prothoracic gland cells to growth factors from hemolymph may play roles in regulating DNA synthesis of gland cells...
  71. ncbi Remodeling of an identified motoneuron during metamorphosis: hormonal influences on the growth of dendrites and axon terminals
    Laura M Knittel
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, Portland, 97239, USA
    J Neurobiol 63:106-25. 2005
    ..that remodeling of MNs during metamorphosis is mediated by the same hormones that control metamorphosis: the ecdysteroids and juvenile hormone (JH)...
  72. ncbi Edysteroid receptor (EcR) shows marked differences in temporal patterns between tissues during larval-adult development in Rhodnius prolixus: correlations with haemolymph ecdysteroid titres
    Xanthe Vafopoulou
    Biology Department, York University, 4700 Keele St, Toronto, Ontario, Canada, M3J 1P3
    J Insect Physiol 51:27-38. 2005
    ..of 70, 68 and 64 kDa, from epidermis and fat body of developing larvae, which contain high levels of haemolymph ecdysteroids. These peptides are absent from both unfed larvae and adults, which are devoid of ecdysteroids...
  73. ncbi Analysis of ecdysteroidogenic activity of the prothoracic glands during the last larval instar of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404 19, Taiwan, ROC
    Arch Insect Biochem Physiol 58:17-26. 2005
    ....
  74. ncbi Critical period for pupal commitment in the yellow fever mosquito, Aedes aegypti
    Que Lan
    Department of Entomology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Insect Physiol 50:667-76. 2004
    ..Levels of transcription of the ecdysone receptor gene show a small peak between 12 and 24 h, and a larger peak between 46 and 66 h after ecdysis to the fourth instar...
  75. ncbi Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo
    Xin Liu
    Institute of Nuclear Agricultural Science, Zhejiang University, Zhejiang, China
    Arch Insect Biochem Physiol 56:155-61. 2004
    ..This is the first evidence that Bom-PTSP inhibits in vivo ecdysteroidogenesis in the silkworm...
  76. ncbi Cross communication between signaling pathways: juvenoid hormones modulate ecdysteroid activity in a crustacean
    Xueyan Mu
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh 27695 7633, USA
    J Exp Zool A Comp Exp Biol 301:793-801. 2004
    ..While juvenoids functioned as anti-ecdysteroids in both intact embryos and in cultured cells, 20-hydroxyecdysone showed no evidence of acting as an anti-..
  77. ncbi C-25 epimeric 26-haloponasterone A: synthesis, absolute configuration and moulting activity
    Boon Ek Yingyongnarongkul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Steroids 70:636-44. 2005
    ..The results indicated that the configuration at C-25 and the substituent at C-26 have significant influences on the interaction of ecdysteroids with their receptor.
  78. ncbi Complex steroid-peptide-receptor cascade controls insect ecdysis
    D Zitnan
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84506 Bratislava, Slovakia
    Gen Comp Endocrinol 153:88-96. 2007
    ..2) Release and interaction of Inka cell peptide hormones and multiple central neuropeptides to control consecutive phases of the ecdysis sequence...
  79. ncbi Importance of sterols acquired through host feeding in synovigenic parasitoid oogenesis
    Nathalie Mondy
    Universite Francois Rabelais, IRBI UMR CNRS 6035, Parc Grandmont, F 37200 Tours, France
    J Insect Physiol 52:897-904. 2006
    ..This result has important implications for understanding both the nutrient allocation strategy in this species and the impact of cholesterol in parasitoid reproduction...
  80. ncbi Stage-dependent effects of starvation on the growth, metamorphosis, and ecdysteroidogenesis by the prothoracic glands during the last larval instar of the silkworm, Bombyx mori
    Chien Hung Chen
    Chung Hwa College of Medical Technology, 89 Wen Hwa 1st Road, Jen Te Hsiang, Tainan County 717, Taiwan, ROC
    J Insect Physiol 52:968-74. 2006
    ..starvation, a deficiency in PTTH signal transduction was maintained, which led to very low levels of hemolymph ecdysteroids after the beginning of starvation...
  81. ncbi Developmental expression and hormonal regulation of different isoforms of the transcription factor E75 in the tobacco hornworm Manduca sexta
    Bela Keshan
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Dev Biol 295:623-32. 2006
    ..Neither E75A nor E75D mRNA was up-regulated by JH alone. Thus, E75C is primarily involved in adult differentiation whereas E75D has roles both during the molt and pupal commitment...
  82. ncbi Modulation of the ecdysteroid-induced cell death by juvenile hormone during pupal wing development of Lepidoptera
    Saori Lobbia
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Arch Insect Biochem Physiol 65:152-63. 2007
    ..These results indicate that JH modulates the ecdysteroid action to induce the cell death on pupal wings, generally in Lepidoptera...
  83. ncbi Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)
    Venu M Margam
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    J Insect Physiol 52:558-68. 2006
    ..Three peaks of ecdysteroids occurring at approximately 24, 30-33 and 45-48h after ecdysis to the fourth instar larval stage were detected...
  84. ncbi Hormonal correlates of reproductive status in the queenless ponerine ant, Streblognathus peetersi
    Colin Brent
    School of Life Sciences, Arizona State University, Box 4501, Tempe, AZ 85287, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:315-20. 2006
    ..results support the hypothesis that JH suppresses ovarian function in these queenless ants, and suggest that ecdysteroids may be responsible for stimulating vitellogenin production...
  85. ncbi Differential regulation of ecdysteroidogenic P450 gene expression in the silkworm, Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 71:2808-14. 2007
    ..These results explain well the developmental fluctuation patterns of the P450 gene transcripts in the PG, indicating that multiple factors coordinate to regulate basal PG activity during insect development...
  86. ncbi The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster
    Christen Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 15:1796-807. 2005
    ..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved...
  87. ncbi The ecdysteroidogenic P450 Cyp302a1/disembodied from the silkworm, Bombyx mori, is transcriptionally regulated by prothoracicotropic hormone
    R Niwa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan
    Insect Mol Biol 14:563-71. 2005
    ..Furthermore, dib-Bm expression in cultured PGs is significantly induced by treatment with prothoracicotropic hormone. This is the first report on the transcriptional induction of a steroidogenic gene by the tropic hormone in insects...
  88. ncbi Testis ecdysiotropic peptides in Rhodnius prolixus: biological activity and distribution in the nervous system and testis
    Xanthe Vafopoulou
    Biology Department, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    J Insect Physiol 51:1227-39. 2005
    In Rhodnius prolixus, testes from both pharate adult and adult males are shown to produce and release ecdysteroids in vitro...
  89. pmc Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, United States
    Mech Dev 125:299-313. 2008
    ..These data suggest that the expression of Tcbr during the final instar larval stage promotes pupal program while suppressing the larval and adult programs ensuring a transitory pupal stage in holometabolous insects...
  90. ncbi Hormonal control of tick development and reproduction
    H H Rees
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, UK
    Parasitology 129:S127-43. 2004
    b>Ecdysteroids (moulting hormones), juvenoids and neuropeptides in ticks are reviewed but, by far, the emphasis is on the former since this class of hormones has been the subject of most investigations...
  91. ncbi Smt3 is required for Drosophila melanogaster metamorphosis
    Ana Talamillo
    Functional Genomics Unit, CIC bioGUNE, Technology Park, Building 801 A, 48160 Derio, Bizkaia, Spain
    Development 135:1659-68. 2008
    ..in the prothoracic gland, which controls key developmental processes through the synthesis and release of ecdysteroids, caused a 4-fold prolongation of larval life and completely blocked the transition from larval to pupal stages...
  92. ncbi Juvenile hormone esterase activity in the pupating and diapausing larvae of Sesamia nonagrioides
    Christa Schafellner
    Department of Forest Entomology, Forest Pathology, and Forest Protection, University of Natural Resources and Applied Life Sciences, Hasenauerstrasse 38, A 1190 Vienna, Austria
    J Insect Physiol 54:916-21. 2008
    ..of an ecdysteroid agonist suggests that the drop of activity is a rapid and possibly direct response to ecdysteroids or their agonist...
  93. ncbi Autocrine activation of ecdysteroidogenesis in the prothoracic glands of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404, ROC
    J Insect Physiol 53:538-49. 2007
    ....
  94. ncbi The insect hemolymph protein HP19 mediates the nongenomic effect of ecdysteroids on acid phosphatase activity
    Abul Arif
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India
    J Biol Chem 279:28000-8. 2004
    ..In addition, we show that HP19 inhibits the 20E-induced phosphorylation of the hexamerin receptor protein...
  95. ncbi Ecdysteroid control of cell cycle and cellular commitment in insect wing imaginal discs
    Takashi Koyama
    Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Mol Cell Endocrinol 213:155-66. 2004
    ....
  96. ncbi The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis
    G J Fisk
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112 5331, USA
    Cell 93:543-55. 1998
    Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies...
  97. ncbi Analysis of metamorphosis in Drosophila melanogaster: characterization of giant, an ecdysteroid-deficient mutant
    M B Schwartz
    Dev Biol 103:85-95. 1984
    ..Unlike previously reported ecdysteroid-deficient mutants, however, giant larvae eventually develop into adults and may be induced to undergo complete metamorphosis at the same time as wild type by feeding 20-hydroxyecdysone...
  98. ncbi Neuropeptides and peptide hormones in Anopheles gambiae
    Michael A Riehle
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 298:172-5. 2002
    ..gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito...
  99. ncbi Molecular cloning and induction of nuclear receptors from insect cell lines
    Jian Hua Chen
    School of Biological Sciences, University of Liverpool, Life Sciences Building, Crown Street, L69 7ZB, UK
    Insect Biochem Mol Biol 32:657-67. 2002
    ....
  100. ncbi Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila
    Michael Bialecki
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East, University of Utah, Salt Lake City 84112, USA
    Dev Cell 3:209-20. 2002
    ..We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle...
  101. ncbi Entomogenous fungus Nomuraea rileyi inhibits host insect molting by C22-oxidizing inactivation of hemolymph ecdysteroids
    Makoto Kiuchi
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Arch Insect Biochem Physiol 52:35-44. 2003
    ..rileyi controls B. mori development by inactivating hemolymph molting hormone, ecdysteroids. Incubation of ecdysone (E) and 20-hydroxyecdysone (20E) in fungal-conditioned medium resulted in their rapid ..

Research Grants42

  1. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
    ..Juvenile hormone (JH) and ecdysteroids (20-hydroxyecdysone, 20E is the most active form) are the major hormones that regulate development and ..
  2. Context-specific Functions of CDK8
    Jun Yuan Ji; Fiscal Year: 2013
    ..The importance of this project is highlighted by the fact that dysregulation of lipid homeostasis durin development is closely linked to diseases such as diabetes, obesity, cardiovascular diseases, and certain types of cancers. ..
  3. Integrating physiological and genetic mechanisms of body size regulation
    Viviane Callier; Fiscal Year: 2013
    ..for decades, and more recent research has elucidated the signaling pathways that regulate the synthesis of ecdysteroids. However, the mechanisms that a larva uses to sense its size and activate these signaling pathways are largely ..
  4. LIGHT-ACTIVATED GENE EXPRESSION IN SINGLE CELLS WITHIN TISSUE
    Robert H Singer; Fiscal Year: 2011
    ..that controls how and where other proteins are made in the cell. We are particularly interested in proteins that cause cancer, oncogenes, and in determining how these proteins can induce cells to produce tumors. ..
  5. Ecdysteroid Signaling in Filarial Parasites
    Thomas R Unnasch; Fiscal Year: 2013
    ..Furthermore, the indirect evidence suggesting that ecdysteroids may be important in filarial embryogenesis suggests that compounds targeting the EcR may disrupt parasite ..
  6. CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOS
    PETER STEPONKUS; Fiscal Year: 1993
    ..This will include additions of ecdysteroids, dopa, and dopamine to the culture medium to maximize sclerotization during larval development...
  7. MOLECULAR BASIS OF ECDYSTEROID ACTION IN THE MOSQUITO
    ALEXANDER SIMEON RAIKHEL; Fiscal Year: 2013
    ....
  8. REPRODUCTION IN TICKS AND MITES
    James Oliver; Fiscal Year: 1993
    ..from males and Egg Development Stimulation Factor (EDSF), juvenile hormone-like factor (JH-F) and ecdysteroids; (4) identify the descriptive and experimental approaches to elucidate critical gaps in knowledge of ..
  9. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
    ..The roles of ecdysteroids and juvenile hormone in regulation of ETH and FLP expression in the EG as well as the sensitivity of EGs to ..
  10. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991
    ..With the adult ecdysiotropic factor (ETF), which stimulates secretion of ecdysteroids by the ovaries, purified to homogeniety, sequencing work will continue...
  11. ECDYSTEROID REGULATION OF INVERTEBRATE CALCITONIN
    LAURENS SMITH; Fiscal Year: 1993
    ..The molting process is controlled by ecdysteroids whose actions are mediated by nuclear receptors that have recently been cloned and found to be structurally and ..
  12. INTERFERENCE WITH STEROID RESPONSE GENES IN LEPIDOPTERA
    Lynn Riddiford; Fiscal Year: 2002
    The long-term goal of the parent grant is to understand how ecdysteroids and juvenile hormone (JH) act at the cellular and molecular level to coordinate insect molting and metamorphosis using the polymorphic epidermis of the tobacco ..
  13. ENDOCRINE CONTROL OF VITELLOGENESIS IN DROSOPHILA
    David Richard; Fiscal Year: 2002
    ..1998, 2001a). This proposal studies the levels of production and action of ecdysteroids, juvenile hormones, sex peptide and yolk proteins (YPs) by wild-type Canton-S females, Canton-S females in ..
  14. POSTEMBRYONIC DEVELOPMENT OF LEG MOTOR CIRCUITS
    Richard Levine; Fiscal Year: 2000
    ..Basic knowledge derived from this well-defined model system will augment information being generated in other systems to provide a firm understanding of how motor systems develop and sustain normal function. ..
  15. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2004
    ..males and deaf females in species with auditory sexual dimorphism, emphasizing the role of juvenile hormone and ecdysteroids. The project seeks to substantiate the hypothesis that many seemingly disparate insect ears have, in fact, ..
  16. STERIOD REGULATION OF CNS PLASTICITY
    JAMES TRUMAN; Fiscal Year: 1990
    ..The system involves the action of the steroid hormones, the ecdysteroids, on the nervous system of the hawkmoth, Manduca sexta...
  17. NEUROCHEMICAL CORRELATES OF SOCIAL STATUS IN CRAYFISH
    Robert Huber; Fiscal Year: 2000
    ..Our main effort will focus on amines and ecdysteroids in the CNS or hemolymph, and we plan to develop the groundwork for a future R01 focusing on changes in gene ..
  18. Control of Target Gene Expression by Ecdysteroid
    David Champlin; Fiscal Year: 2002
    ..One long-term goal of the project, although beyond the scope of the current proposal, is to extend the findings of the detailed promoter analysis begun here into analysis of target gene expression in the developing fly. ..
  19. Light-Induced Protein Expression
    David Lawrence; Fiscal Year: 2004
    ..We wilt prepare caged ecdysteroids that can be photochemically unleashed using two-photon illumination...
  20. BIOCHEMICAL ANALYSIS OF THE ACTION OF HORMONES
    LAWRENCE GILBERT; Fiscal Year: 1999
    ....
  21. Comparative Functional Genomics of Drosophila Obesity
    Andrew Clark; Fiscal Year: 2009
    ..which particular genes and pathways are most relevant to variation in fat storage homeostasis, and by developing a systems biology approach to make inferences from data that span cellular, endocrine, and whole-organism attributes ..
  22. Investigation of a development checkpoint in flies
    Adrian Halme; Fiscal Year: 2007
    ....
  23. Nutritional and endocrine control of mosquito egg development.
    Aparna Telang; Fiscal Year: 2008
    ..Identification and characterization of these genes should expand our understanding of hematophagy and pathogen transmission in mosquito vectors. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  25. Role of USP Ligand Binding Pocket During Development
    Grace Jones; Fiscal Year: 2008
    ..The outcome will have broad implications for insect endocrinology, enabling specific tests on the Aedes USP, the results of which will yield new insights on hormonal signaling in the technically more difficult mosquito. ..
  26. STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP
    Grace Jones; Fiscal Year: 2002
    ....
  27. DEVELOPMENTAL CHANGES IN NEURONAL FORM AND FUNCTION
    Janis Weeks; Fiscal Year: 2002
    ..In insects, steroid hormones (ecdysteroids) regulate neural changes during metamorphosis, including programmed cell death (PCD) and the growth or ..
  28. Regulation of Steroid Hormone Synthesis by MAP Kinases
    Robert Rybczynski; Fiscal Year: 2004
    ..Feedback of ecdysteroids on the prothoracic gland down-regulates the ability of the gland to further synthesize ecdysteroids...
  29. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
    ..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
  30. PREPUPAL ACTIVATION OF JH ESTERASE GENE
    Grace Jones; Fiscal Year: 2003
    ..abstract_text> ..
  31. Estrogen Receptor-related Receptor Action in Zebrafish
    Ann Tarrant; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Induction of breast cancer in MMTVneu mice
    William Baldwin; Fiscal Year: 2002
    ..Overall, the purpose of this study is to examine 4-nonylphenol's effects on breast cancer growth and its mechanism of action on the mammary tumor. ..
  33. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2004
    ..These studies provide cloned genes, molecular approaches, and characterization of regulatory processes that can potentially be manipulated to interfere with disease transmission by blood-feeding arthropods. ..
  34. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Frederik Stevens; Fiscal Year: 2010
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  35. Intracellular transfer of cholesterol in mosquitoes
    Que Lan; Fiscal Year: 2010
    ..The results will also validate the potential of targeting cholesterol metabolism for the development of new strategies to control mosquito populations. ..
  36. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2003
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  37. ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATION
    Ann Fallon; Fiscal Year: 2001
    ..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors. ..
  38. Hormonal Control of Insect Epidermis
    Lynn Riddiford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. In vitro culture and transformation of Wolbachia from mosquitoes
    Ann Fallon; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. Hybrid triple quadrupole linear ion trap mass spectrometer
    Jan Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  41. INSECT MODEL FOR STUDY OF THE INSULIN RECEPTOR
    Wendy Smith; Fiscal Year: 2002
    ..Such work will further basic understanding of the early insulin receptor, and be potentially applicable to the development of novel insect control agents. ..