collagen type iii

Summary

Summary: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.

Top Publications

  1. pmc G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
    Rong Luo
    Division of Newborn Medicine, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:12925-30. 2011
  2. pmc Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis
    Efstathios Vassiliadis
    Assay Development, Nordic Bioscience, Herlev Hovedgade 207, DK 2730, Copenhagen, Denmark
    BMC Dermatol 11:6. 2011
  3. pmc Human corneal fibrosis: an in vitro model
    Dimitris Karamichos
    Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1382-8. 2010
  4. ncbi Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Am J Clin Pathol 126:725-35. 2006
  5. ncbi Increased collagen content in insulin-resistant skeletal muscle
    Rachele Berria
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Physiol Endocrinol Metab 290:E560-5. 2006
  6. ncbi Immediate inflammatory response and scar formation in wounded vocal folds
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 115:921-9. 2006
  7. ncbi Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis
    Ling Zhang
    Department of Pathology, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90095, USA
    J Biol Chem 279:28315-9. 2004
  8. ncbi Vascular Ehlers-Danlos syndrome
    Dominique P Germain
    Clinical Genetics Unit, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France
    Ann Genet 47:1-9. 2004
  9. ncbi Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts
    Zimin Wang
    Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    J Plast Reconstr Aesthet Surg 60:1193-9. 2007
  10. pmc Use of biomarkers of collagen types I and III fibrosis metabolism to detect cardiovascular and renal disease in chimpanzees (Pan troglodytes)
    John J Ely
    Alamogordo Primate Facility, Charles River Consulting and Staffing Services, Holloman Airforce Base, New Mexico, USA
    Comp Med 60:154-8. 2010

Detail Information

Publications238 found, 100 shown here

  1. pmc G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
    Rong Luo
    Division of Newborn Medicine, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:12925-30. 2011
    ..Thus, collagen III regulates the proper lamination of the cerebral cortex by acting as the major ligand of GPR56 in the developing brain...
  2. pmc Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis
    Efstathios Vassiliadis
    Assay Development, Nordic Bioscience, Herlev Hovedgade 207, DK 2730, Copenhagen, Denmark
    BMC Dermatol 11:6. 2011
    ..The aim was to investigate CO3-610 levels in another well characterised model of fibrosis, to better describe the biomarker in relation to additional fibrotic pathologies...
  3. pmc Human corneal fibrosis: an in vitro model
    Dimitris Karamichos
    Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1382-8. 2010
    ..This model mimics corneal development. The authors postulate that with the addition of TGF-beta1, a 3-D corneal scar model can be generated...
  4. ncbi Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Am J Clin Pathol 126:725-35. 2006
    ..Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling...
  5. ncbi Increased collagen content in insulin-resistant skeletal muscle
    Rachele Berria
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Am J Physiol Endocrinol Metab 290:E560-5. 2006
    ..We conclude that changes in the composition of the extracellular matrix are a general characteristic of insulin-resistant muscle...
  6. ncbi Immediate inflammatory response and scar formation in wounded vocal folds
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 115:921-9. 2006
    ..Thus, we examined the inflammation profile and extracellular matrix production in wounded vocal folds in the acute phase of wound healing...
  7. ncbi Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis
    Ling Zhang
    Department of Pathology, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90095, USA
    J Biol Chem 279:28315-9. 2004
    ..Thus, PKC-delta may play a critical role in the pathogenesis of pulmonary fibrosis and may serve as a molecular target for therapeutic intervention to suppress fibrosis...
  8. ncbi Vascular Ehlers-Danlos syndrome
    Dominique P Germain
    Clinical Genetics Unit, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France
    Ann Genet 47:1-9. 2004
    ....
  9. ncbi Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts
    Zimin Wang
    Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    J Plast Reconstr Aesthet Surg 60:1193-9. 2007
    ..In this paper, we examined the function of Sma and Drosophila mothers against decapentaplegic homolog 3 (Smad3), recently characterized as intracellular effector of TGF-beta signalling, in keloid fibroblasts using siRNA...
  10. pmc Use of biomarkers of collagen types I and III fibrosis metabolism to detect cardiovascular and renal disease in chimpanzees (Pan troglodytes)
    John J Ely
    Alamogordo Primate Facility, Charles River Consulting and Staffing Services, Holloman Airforce Base, New Mexico, USA
    Comp Med 60:154-8. 2010
    ..Furthermore, both biomarkers showed a significant trend to increase with disease severity. We conclude that ICTP and PIIINP warrant further study for antemortem detection of renal and myocardial fibrosis in chimpanzees...
  11. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
    ..IHC was specific for procollagen type I, collagen type I, collagen type III, collagen type IV, elastin, decorin, fibronectin and hyaluronic acid binding protein 2...
  12. pmc The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures
    Michael J Monument
    Division of Orthopaedic Surgery, Faculty of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Inflamm Res 61:285-92. 2012
    ..Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis...
  13. pmc Hypertrophic versus non hypertrophic scars compared by immunohistochemistry and laser confocal microscopy: type I and III collagens
    Gisele V Oliveira
    Shriners Burns Hospital, Galveston, TX, USA
    Int Wound J 6:445-52. 2009
    ..Easily accessed by immunohistochemistry and confocal microscopy, type III collagen deposition may help in determining scar phenotype, differentiating hypertrophic and non hypertrophic scars...
  14. ncbi Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III
    Robert Jan Lebbink
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Matrix Biol 28:202-10. 2009
    ....
  15. ncbi Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle
    K M Heinemeier
    Institute of Sports Medicine, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 106:178-86. 2009
    ..Furthermore, the tendon response was clearly different and less pronounced than the muscle tissue response...
  16. ncbi Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III
    Nicolas Raynal
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:3821-31. 2006
    ..We describe two novel high affinity integrin-binding motifs in human collagen III (GROGER and GLOGEN) and a third motif (GLKGEN) that displays intermediate activity. Each motif was verified using shorter synthetic peptides...
  17. pmc Location of 3-hydroxyproline residues in collagen types I, II, III, and V/XI implies a role in fibril supramolecular assembly
    Mary Ann Weis
    Orthopaedic Research Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195 6500, USA
    J Biol Chem 285:2580-90. 2010
    ..Two of these B-clade sites were spaced apart by 231 residues. From these and other observations we propose a fundamental role for 3Hyp residues in the ordered self-assembly of collagen supramolecular structures...
  18. ncbi A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen
    N Barascuk
    Nordic Bioscience A S, Herlev, Denmark
    Clin Biochem 43:899-904. 2010
    Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for quantification of MMP-9 derived collagen type III (CO3) degradation.
  19. ncbi Relationship between pressure-volume curve and markers for collagen turn-over in early acute respiratory distress syndrome
    Alexandre Demoule
    Unité INSERM U615 Université Paris 12, Faculté de Médecine de Créteil, Paris, France
    Intensive Care Med 32:413-20. 2006
    ....
  20. ncbi Non-cross-linked porcine-based collagen I-III membranes do not require high vascularization rates for their integration within the implantation bed: a paradigm shift
    Shahram Ghanaati
    REPAIR Lab, Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Acta Biomater 8:3061-72. 2012
    ..This hypothesis could explain the observed clinical complications associated with the retrieval of these materials after guided tissue regeneration...
  21. ncbi MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer
    Yutaka Naito
    Department of Molecular Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    Cancer Sci 105:228-35. 2014
    ..In stromal cells, miR-143 enhanced collagen type III expression in normal gastric fibroblasts and cancer-associated fibroblasts through activation of ..
  22. ncbi Collagen Type III Glomerulopathies
    Arthur H Cohen
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Adv Chronic Kidney Dis 19:101-6. 2012
    The 2 rare disorders characterized by the pathological accumulation of collagen type III in glomeruli are discussed...
  23. ncbi Efficient inhibition of fibroblast proliferation and collagen expression by ERK2 siRNAs
    Fengfeng Li
    Department of Orthopaedics, The Sixth Affiliated People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Biochem Biophys Res Commun 382:259-63. 2009
    ..MTT assays and flow cytometry revealed marked inhibition of RJATF proliferation, but no apoptosis. In conclusion, LV-mediated ERK2 siRNAs may represent novel therapies or drug targets for preventing joint adhesion formation...
  24. ncbi Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins
    P Sansilvestri-Morel
    Division of Angiology, Servier Research Institute, Suresnes, France
    J Vasc Res 38:560-8. 2001
    ..An imbalance between the synthesis of collagen type I protein (collagen I) and collagen type III protein (collagen III) could explain the lack of elasticity of varicose veins...
  25. ncbi Localized unfolding of collagen explains collagenase cleavage near imino-poor sites
    Collin M Stultz
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    J Mol Biol 319:997-1003. 2002
    ..The results are consistent with a model for collagenase cleavage where partial unfolding of imino-poor regions enables collagenases to gain access to their cleavage sites...
  26. ncbi Histological study of acute vocal fold injury in a rat model
    Tomoko Tateya
    Division of Otolaryngology Head and Neck Surgery, Dept of Surgery, University of Wisconsin Madison, K4 789 CSC 600 Highland Ave, Madison, WI 53792 USA
    Ann Otol Rhinol Laryngol 115:285-92. 2006
    ..We used an acute vocal fold injury in a rat model to characterize vocal fold wound healing by studying the expression pattern of the extracellular matrix components in the vocal fold lamina propria...
  27. ncbi Proliferation assessment of primary human mesenchymal stem cells on collagen membranes for guided bone regeneration
    Qin Liu
    Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia
    Int J Oral Maxillofac Implants 26:1004-10. 2011
    ..A special focus was set on short-term eluates derived from collagen membranes, as volatile toxic materials washed out from these membranes may influence cell behavior during the short time course of oral surgery...
  28. ncbi Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge
    Annette T Hastie
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, and Division of Clinical Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
    Am J Respir Crit Care Med 165:266-72. 2002
    ..from epithelium harvested from asthmatics, but not from nonasthmatics, at 1 to 2 wk postchallenge stimulated collagen type III production 50% to 70% (p = 0.043 for clinical group, p = 0.012 for day, and p = 0...
  29. pmc Structural and biochemical evaluation of the elbow capsule after trauma
    Mark S Cohen
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Shoulder Elbow Surg 16:484-90. 2007
    ..This study demonstrates pathologic thickening, disorganization of the collagen fiber arrangement, and involvement of cytokines in the pathology of post-traumatic contracture of the elbow...
  30. ncbi Histologic characterization of rat vocal fold scarring
    Tomoko Tateya
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 114:183-91. 2005
    ..histologically analyzed with Alcian blue stain, trichrome stain, and immunofluorescence of collagen type I, collagen type III, and fibronectin...
  31. ncbi RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts
    Qiong Wang
    Department of Dermatology, Second Hospital of Xi an Jiaotong University, Shaanxi, China
    Exp Dermatol 16:611-7. 2007
    ..21% and 22.12% of control levels). These stably modified HSF cell lines may be used for the study of other types of collagen or proteins of the extracellular matrix (ECM)...
  32. pmc High rate of joint capsule matrix turnover in chronic human elbow contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 439:228-34. 2005
    ..The results indicate that joint capsule matrix molecule mRNA levels are altered in the chronic stages of posttraumatic elbow contractures in humans, potentially creating an environment with high matrix turnover rates...
  33. ncbi Xenogeneic collagen matrix with coronally advanced flap compared to connective tissue with coronally advanced flap for the treatment of dehiscence-type recession defects
    Michael K McGuire
    J Periodontol 81:1108-17. 2010
    ..This study determines if a xenogeneic collagen matrix (CM) with CAF might be as effective as CTG+CAF in the treatment of recession defects...
  34. ncbi Pathological characterization of collagenofibrotic glomerulonephropathy in a young dog
    Ryosuke Kobayashi
    Research Institute of Biosciences, Azabu University, Sagamihara, Japan
    J Vet Med Sci 71:1137-41. 2009
    ..The clinical, histopathological, immunohistochemical and electron microscopic findings of the present dog were consistent with those of the human, childhood form of collagenofibrotic glomerulonephropathy...
  35. ncbi A canine autosomal recessive model of collagen type III glomerulopathy
    Runa Rørtveit
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    Lab Invest 92:1483-91. 2012
    b>Collagen type III glomerulopathy (Col3GP) is a rare renal disease characterized by massive glomerular accumulations of collagen type III...
  36. ncbi Collagenofibrotic glomerulonephropathy with fibronectin deposition in a dog
    J Kamiie
    Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501, Japan
    Vet Pathol 46:688-92. 2009
    ..This is the first report of CFGN in a nonhuman species with glomerular deposition of fibronectin and type III collagen...
  37. ncbi Evidence for an extensive collagen type III proximal domain in the rat femur. II. Expansion with exercise
    H Saino
    School of Biomedical Sciences, University of Leeds, Clarendon Way, Leeds LS2 9LU, UK
    Bone 32:660-8. 2003
    ..An image analyser measured femoral neck and midshaft microarchitecture, while immunostaining localized collagen type III-rich fibres (CIII, an index of Sharpey fibre insertions) and osteopontin-rich osteons (OPN, an index of ..
  38. pmc Fibrillin-1 in incisional hernias: an immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae
    Martin Fricke
    Dept of Histology, University of Gottingen, Germany
    J Anat 212:674-85. 2008
    ..Our results suggest that fibrillin-1 is a relevant factor contributing to tissue stability. Disturbances in its deposition, even before scar formation, may be an important factor to the development of incisional hernias...
  39. ncbi Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 117:227-38. 2008
    ..To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation...
  40. ncbi Abnormal primary tissue collagen composition in the skin of recurrent incisional hernia patients
    Brent White
    Hernia Institute, Emory Endosurgery Unit, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am Surg 73:1254-8. 2007
    ..Such a primary collagen defect, in addition to abnormal scar formation, likely plays a significant role in the pathogenesis of recurrent incisional hernias...
  41. ncbi Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze
    Yasutaka Hayashida
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Invest Ophthalmol Vis Sci 47:552-7. 2006
    ..To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze...
  42. ncbi The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament
    Chun yi Lee
    Department of Orthopaedic Surgery, China Medical University Hospital, Taichung, Taiwan
    Matrix Biol 23:323-9. 2004
    ....
  43. ncbi Evidence for an extensive collagen type III/VI proximal domain in the rat femur. I. Diminution with ovariectomy
    F Luther
    School of Biomedical Sciences, University of Leeds, Clarendon Way, Leeds LS2 9LU, UK
    Bone 32:652-9. 2003
    ..1-4 months postoperation, cancellous atrophy was histologically confirmed, and the immunolocalization of collagen Type III was examined...
  44. ncbi A functional variant of the collagen type III alpha1 gene modify risk of sporadic intracranial aneurysms
    Jingzhou Chen
    Sino German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Beijing 100037, People s Republic of China
    Hum Genet 131:1137-43. 2012
    ..The associations were independent of the presence of hemorrhagic stroke and hypertension. These results support the view that the functional variant of COL3A1 is genetic risk factors for IAs in the Chinese population...
  45. ncbi Immunohistochemical findings after LASIK confirm in vitro LASIK model
    Siegfried G Priglinger
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Cornea 25:331-5. 2006
    ..To compare immunohistochemical findings in human donor corneas after successful laser in situ keratomileusis (LASIK) without clinical complications with a recently established human LASIK in vitro model...
  46. ncbi Laser in situ keratomileusis in human corneas: new organ culture model
    Christian Albrecht May
    Department of Anatomy II, Friedrich Alexander University, Erlangen, Germany
    J Cataract Refract Surg 30:179-86. 2004
    ..To establish an in vitro model of laser in situ keratomileusis (LASIK) in human donor eyes and to test its validity in comparison with animal models...
  47. ncbi Matrix metalloproteinase-1 cleavage site recognition and binding in full-length human type III collagen
    Kim E Williams
    FibroGen, Inc 409 Illinois Street, San Francisco, CA 94158, USA
    Matrix Biol 28:373-9. 2009
    ..The relaxed tertiary structure in the MMP cleavage region may permit local collagen unwinding by MMP-1 that enables site-specific proteolysis...
  48. pmc Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex
    Yoshihiro Ishikawa
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, and Research Department, Shriners Hospital for Children, Portland, OR 97239, USA
    J Biol Chem 284:17641-7. 2009
    ..The P3H1.CRTAP.CypB complex also delayed the in vitro fibril formation of type I collagen, indicating that this complex is also able to interact with triple helical collagen and acts as a collagen chaperone...
  49. ncbi Trichostatin A, lead compound for development of antifibrogenic drugs
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Acta Gastroenterol Belg 64:239-46. 2001
    ..Hyperacetylation of histone H4 showed to be maximal at 10(-7) M TSA. Primary hepatic stellate cells were more affected by TSA than subcultured stellate cells...
  50. ncbi Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis
    Sanne S Veidal
    Nordic Bioscience, Herlev, Denmark
    Liver Int 30:1293-304. 2010
    ..These neo-epitopes may be used as markers of fibrosis...
  51. ncbi Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen--A novel biomarker of atherosclerotic plaque remodeling
    Natasha Barascuk
    Nordic Bioscience A S, Herlev, Denmark University of Southern Denmark, Odense, Denmark
    Clin Biochem 44:900-6. 2011
    ..Degradation of collagen in the arterial wall by matrix metalloproteinases is the hallmark of atherosclerosis. We have developed an ELISA for the quantification of type III collagen degradation mediated by MMP-9 in urine...
  52. pmc Interleukin-1 participates in the progression from liver injury to fibrosis
    Roben G Gieling
    Department of Surgery, The Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1324-31. 2009
    ..Thus IL-1 is an important participant, along with other cytokines, and controls the progression from liver injury to fibrogenesis through activation of HSCs in vivo...
  53. pmc Homozygosity for a null allele of COL3A1 results in recessive Ehlers-Danlos syndrome
    Aurelie Plancke
    CHU Montpellier, France
    Eur J Hum Genet 17:1411-6. 2009
    ..It opens up new perspectives for the understanding of COL3A1 genotype-phenotype correlations, which is required while considering targeted therapy...
  54. ncbi Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3
    Patricia Sansilvestri-Morel
    Division of Angiology, Servier Research Institute, Suresnes, and Department of Cardiovascular Surgery, European Hospital Georges Pompidou, Paris, France
    J Vasc Res 42:388-98. 2005
    ..The degradation of collagen III and fibronectin may have repercussions for the mechanical properties of the venous wall...
  55. ncbi The role of cystine knots in collagen folding and stability, part II. Conformational properties of (Pro-Hyp-Gly)n model trimers with N- and C-terminal collagen type III cystine knots
    Dirk Barth
    Max Planck Institute für Biochemie, Am Klopferspitz 18 A, 82152 Martinsried, Germany
    Chemistry 9:3703-14. 2003
    In mature collagen type III the homotrimer is C-terminally cross-linked by an interchain cystine knot consisting of three disulfide bridges of unknown connectivity...
  56. ncbi Gene expression of type I and type III collagen by mechanical stretch in anterior cruciate ligament cells
    Sung Gon Kim
    Department of Orthopaedic Surgery, Juntendo University, Tokyo, Japan
    Cell Struct Funct 27:139-44. 2002
    ..The results suggest that the stretch-induced mRNA expression of the type I and type III collagen is mediated via an autocrine mechanism of TGF-beta1 released from ligament cells...
  57. ncbi Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease
    M Stumpf
    Department of Surgery, Medical College, Rhenish Westphalian Technical University, Aachen, Germany
    Int J Colorectal Dis 16:271-5. 2001
    ..37+/- 0.32 vs. 1.59 +/- 0.31) and increased levels of collagen type III (1.61+/- 0.32 vs. 1.42 +/- 0.42), with a resulting lower collagen ratio I/III...
  58. ncbi Conformational selection and collagenolysis in type III collagen
    Ramon Salsas-Escat
    Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Proteins 78:325-35. 2010
    ....
  59. ncbi Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection
    Naoshi Fukui
    National Hospital Organization Sagamihara Hospital, Sagamihara, Japan
    Arthritis Rheum 58:154-63. 2008
    ..To determine the change in metabolic activity of chondrocytes in osteoarthritic (OA) cartilage, considering regional difference and degree of cartilage degeneration...
  60. ncbi A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
    Ton Lisman
    Department of Biochemistry, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 108:3753-6. 2006
    ..23 either strongly interacted with both VWF and platelets or lacked both VWF and platelet binding. Thus, we identified the sequence RGQOGVMGF (O is hydroxyproline) as the minimal VWF-binding sequence in collagen III...
  61. ncbi Increased skin collagen extractability and proportions of collagen type III are not normalized after 6 months healing of human excisional wounds
    Simon P Robins
    Matrix Biochemistry, Rowett Research Institute, Bucksburn, Aberdeen, UK
    J Invest Dermatol 121:267-72. 2003
    ..89, p<0.0001) suggests a causal relationship, consistent with the likely effects of a substantial network of mature, inter-helical bonds in collagen...
  62. ncbi Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1
    Suzanne Lam
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 63:878-88. 2003
    ..The present study examined the effect of high ambient glucose and transforming growth factor-beta1 (TGF-beta1) on matrix production by human renal fibroblasts...
  63. pmc Type III collagen, a fibril network modifier in articular cartilage
    Jiann Jiu Wu
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 285:18537-44. 2010
    ....
  64. ncbi Ovariectomy reduces the gelatinolytic activity and expression of matrix metalloproteinases and collagen in rat molar extraction wounds
    K G Zecchin
    Department of Oral Pathology and Genetics, School of Dentistry of Piracicaba, UNICAMP, Limeira Avenue 901 13414 903, CP 52, Piracicaba, Sao Paulo, Brazil
    Calcif Tissue Int 76:136-45. 2005
    ..The results presented here in suggest that the absence of estrogen may possibly contribute to the delayed alveolar wound healing by interfering with the extracellular matrix turnover...
  65. ncbi Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model
    Pauline Po Yee Lui
    Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Rheumatology (Oxford) 49:231-9. 2010
    ....
  66. ncbi Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats
    Pedro Caruso
    Alameda Anapurus 631, ZIP 04087 001, Sao Paulo SP, Brasil
    Intensive Care Med 29:1808-11. 2003
    ....
  67. pmc Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia
    B Asling
    AstraZeneca R and D, Pepparedsleden 1, S 431 83 Molndal, Sweden
    Gut 58:1063-9. 2009
    ..Gastro-oesophageal reflux disease (GORD) is a common gastrointestinal disorder with a genetic component. Our aim was to identify genetic factors associated with GORD...
  68. ncbi Effects of shock waves on tenocyte proliferation and extracellular matrix metabolism
    Yuan Hung Chao
    Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
    Ultrasound Med Biol 34:841-52. 2008
    ..treatment, up-regulation of proliferating cell nuclear antigen (PCNA) (at 6 and 24 h) and collagen type I, collagen type III and TGF-beta1 gene expression (at 24 h) were observed; these were followed by the increases in NO production ..
  69. ncbi Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis
    P A Moalli
    Magee Womens Research Institute and Department of Obstetrics and Gynecology at Magee Womens Hospital, Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Obstet Gynecol 190:620-7. 2004
    ..The arcus tendineous fasciae pelvis (ATFP) provides support to the anterior vagina. The objective of this study was to determine the impact of menopause on the structural components of the ATFP...
  70. ncbi Localization of precursor proteins and mRNA of type I and III collagens in usual interstitial pneumonia and sarcoidosis
    Riitta Kaarteenaho-Wiik
    Department of Pathology, University of Oulu, and Oulu University Hospital, Oulu, Finland
    J Mol Histol 36:437-46. 2005
    ..We conclude that the expression of precursor proteins and mRNA of type I and type III collagens is increased in UIP and sarcoidosis, reflecting mainly active synthesis of these collagens in different areas of the lung...
  71. ncbi Upregulation of heme oxygenase and collagen type III in the rat bladder after partial bladder outlet obstruction
    Mitsuhiko Inaba
    Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Urol Int 78:270-7. 2007
    ..localization of the enzymes, heme oxygenase and nitric oxide synthase (NOS), with reference to increase of collagen type III in response to the partial obstruction of the bladder...
  72. ncbi What increases type III procollagen mRNA levels in lung tissue: stress induced by changes in force or amplitude?
    Cristiane S N B Garcia
    Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Ilha do Fundao, 21949 900 Rio de Janeiro, RJ, Brazil
    Respir Physiol Neurobiol 144:59-70. 2004
    ..PCIII mRNA expression increased significantly after 1h of oscillation at 10(-2)N and 5% L(B) and remained unchanged for 6h. In conclusion, the stress induced by force but not by amplitude led to the increment in PCIII mRNA expression...
  73. ncbi Distribution of collagen in the lamina propria of the human vocal fold
    Erich Christiano Madruga de Melo
    Department of Otolaryngology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Laryngoscope 113:2187-91. 2003
    ..To describe the arrangement of collagen fibers in the lamina propria of the human vocal fold...
  74. pmc Hernia fibroblasts lack beta-estradiol-induced alterations of collagen gene expression
    Petra Lynen Jansen
    Interdisciplinary Center for Clinical Research BIOMAT, University Hospital Aachen, Germany
    BMC Cell Biol 7:36. 2006
    ..We compared primary fibroblast cultures from male/female subjects without/without incisional hernia disease...
  75. ncbi A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1
    Jiyeun Kate Kim
    The Center for Extracellular Matrix Biology, Texas A and M University Health Science Center, Institute of BioScience and Technology, Houston, 77030, USA
    J Biol Chem 280:32512-20. 2005
    ..Furthermore, the GROGER-containing peptide supported adhesion of human lung fibroblast cells when coated on a culture dish. Thus, we have identified a novel high affinity binding sequence for the collagen-binding integrin I domains...
  76. ncbi Collagen subtypes in human vocal folds
    Tomoko Tateya
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 115:469-76. 2006
    ....
  77. ncbi Type I and III collagen protein precursors and mRNA in the developing human lung
    Riitta Kaarteenaho-Wiik
    Department of Internal Medicine, Oulu University Hospital, University of Oulu, PO Box 5000 Kajaanintie 50, FIN 90014 Oulu, Finland
    J Pathol 203:567-74. 2004
    ..Myofibroblast-type cells appeared to produce mRNA for both types of collagen in alveoli...
  78. ncbi Impaired balance of type I and type III procollagen mRNA in cultured fibroblasts of patients with incisional hernia
    Zhongyi Si
    Department of Surgery, the Department of Internal Medicine II, and the Institute of Pathology, Technical University of Aachen, Aachen, Germany
    Surgery 131:324-31. 2002
    ..We analyzed the type I and type III procollagen messenger RNA to investigate whether these findings represent the altered extracellular matrix or a primary defect at the transcriptional level...
  79. ncbi Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:1616-21. 2003
    ..Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined the role of HSP47 in conjunctival scarring in patients with OCP...
  80. ncbi Recurrent inguinal hernia: disease of the collagen matrix?
    Hong Zheng
    Department of Surgery, Technical University of Aachen, Pauwelstrasse 30, 52057 Aachen, Germany
    World J Surg 26:401-8. 2002
    ..01). Significant differences were caused by the increase of both procollagen type III mRNA and collagen type III protein synthesis...
  81. ncbi Spontaneous direct carotid-cavernous fistula in Ehlers-Danlos syndrome type IV: two case reports and a review of the literature
    Hideki Chuman
    Department of Ophthalmology, University of Michigan Medical Center, Ann Arbor, USA
    J Neuroophthalmol 22:75-81. 2002
    ..Molecular tests can be used to confirm the diagnosis and provide family members with accurate genetic counseling and predictive genetic testing...
  82. ncbi Biophysical characterization of the C-propeptide trimer from human procollagen III reveals a tri-lobed structure
    S Bernocco
    , CNRS UMR 5086, , 69367 Lyon Cedex 7, France
    J Biol Chem 276:48930-6. 2001
    ..We speculate that each of the major lobes corresponds to one of the three component polypeptide chains, which come together in a junction region to connect to the rest of the procollagen molecule...
  83. ncbi Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblasts
    Vikas Batra
    Thomas Jefferson University, Philadelphia, PA, USA
    Chest 123:398S-9S. 2003
  84. pmc Identification of a major GpVI-binding locus in human type III collagen
    Gavin E Jarvis
    Departments of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 111:4986-96. 2008
    ..These data indicate that the ability of a triple-helical peptide to bind GpVI is not solely determined by the presence or spatial arrangement of these OGP/GPO motifs within the peptides...
  85. pmc Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV
    U Schwarze
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 69:989-1001. 2001
    ..This suggests that the major effect of many of these dominant mutations in the "minor" collagen genes may be expressed through protein deficiency rather than through incorporation of structurally altered molecules into fibrils...
  86. ncbi High collagen type I and low collagen type III levels in knee joint contracture: an immunohistochemical study with histological correlate
    Fujio Matsumoto
    Bone and Joint Research Laboratory, University of Ottawa, Canada
    Acta Orthop Scand 73:335-43. 2002
    ..In this respect, contractures differ from granuloma, scar tissue and the pannus of inflammatory arthritis...
  87. ncbi Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats
    Marcel Binnebösel
    Department of Surgery, Aachen University Hospital, Pauwelsstr 30, 52074 Aachen, Germany
    Int J Colorectal Dis 24:433-40. 2009
    ....
  88. ncbi Aneurysm syndromes caused by mutations in the TGF-beta receptor
    Bart L Loeys
    McKusick Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, and the Kennedy Krieger Institute, Baltimore, USA
    N Engl J Med 355:788-98. 2006
    ....
  89. ncbi [Dynamic changes in collagen type I and collagen type III in rabbits infected with Schistosoma japonicum and the effect of gamma-interferon]
    H L Weng
    Institute of Infectious Diseases, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19:26-9. 2001
    OBJECTIVE: To observe the dynamic changes in collagen type I and collagen type III in rabbits with schistosomiasis japonica and the treatment effect of gamma-interferon on the degradation of collagens in schistosomal hepatic fibrosis...
  90. pmc Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol
    Ugo Cioffi
    Department of Surgery, University of Milan, Ospedale Maggiore di Milano IRCCS, Via F Sforza, 35 20122, Milano, Italy
    BMC Public Health 2:19. 2002
    ....
  91. ncbi [Role of fibronectin in rat pulmonary fibrosis]
    H Wu
    Department of Pathology, School of Basic Medical Science, Shanghai Medical University, Shanghai 200032, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:40-2. 2001
    ..05). CONCLUSIONS: FN could up-regulate the synthesis of type I, III procollagen mainly by enhancing the transcriptions of procollagen genes...
  92. ncbi High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1/2
    Mengxiong Tang
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, China
    Mol Cell Biochem 301:109-14. 2007
    ..These results suggest that high glucose accelerates the synthesis of collagen types I and III, and an ERK1/2 cascade in cardiac fibroblasts play an essential role in the control of collagen deposition by high glucose...
  93. ncbi Effects of ionizing radiation on gene expression in cultured rat heart cells
    M Boerma
    LUMC, Department of Clinical Oncology, K1P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Int J Radiat Biol 78:219-25. 2002
    ..To determine the in vitro effect of ionizing radiation on TGF-beta1, FGF-2, IL-1beta, atrial natriuretic peptide (ANP) and procollagen types I and III gene expression in three different cell types of rat heart...
  94. ncbi Eplerenone suppresses neointimal formation after coronary stent implantation in swine
    Kohei Wakabayashi
    Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Kanagawa 227 8501, Japan
    Int J Cardiol 107:260-6. 2006
    ....
  95. ncbi Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone
    Patrick Lacolley
    INSERM EMI U0107, Paris, France
    Circulation 106:2848-53. 2002
    ..Our aim was to determine the effects of Aldo and the Aldo receptor antagonist eplerenone (Epl) on in vivo mechanical properties of the carotid artery using echo-tracking system...
  96. ncbi Adenovirus-mediated expression of cyclooxygenase-2 antisense reverse abnormal genetic profile of human adhesion fibroblasts
    Ghassan M Saed
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Fertil Steril 89:1455-60. 2008
    ....
  97. ncbi Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: transforming growth factor-beta1-dependent and -independent effects
    Y Wang
    Wihuri Research Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 21:1928-33. 2001
    ..Taken together, the findings support the hypothesis that chymase released from activated mast cells in atherosclerotic plaques contributes to cap remodeling...
  98. ncbi The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization
    M G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University Texas Medical Branch Galveston, TX 77550, USA
    Gene Ther 14:1235-42. 2007
    ..In conclusion, exogenous administration of liposomal IGF-I plus KGF cDNA enhanced dermal and epidermal regeneration which is due to increased neovascularization...
  99. ncbi Role of TGF-beta1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats
    Hiroyuki Yoshikawa
    Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, 807 8555 Japan
    Am J Physiol Gastrointest Liver Physiol 282:G549-58. 2002
    ..Our results suggest that the development of pancreatic fibrosis in OLETF rats extends from endocrine to exocrine pancreas and that TGF-beta1 is involved in pancreatic fibrosis of OLETF rats...
  100. ncbi Heart function and molecular biological parameters are comparable in young adult and aged rats after chronic myocardial infarction
    Alexander Deten
    Carl Ludwig Institute of Physiology, Leipzig University, Liebigstr 27, D 04103 Leipzig, Germany
    Cardiovasc Res 66:364-73. 2005
    ..To test the hypothesis that IL-1beta and IL-6 play a pivotal role after myocardial infarction (MI) particularly in aged rats...
  101. ncbi The modulating effect of L-arginine on collagen metabolism of pulmonary artery in pulmonary hypertension induced by a left-to-right shunt
    Bing Wei
    Department of Pediatrics, First Hospital, Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 82:1273-5. 2002
    ..To explore the modulating effect of L-arginine on collagen metabolism of pulmonary artery in rats with high pulmonary blood flow-induced pulmonary hypertension and its molecular mechanism...

Research Grants62

  1. Oxygen versus PAP for treatment of sleep apnea in chronic heart failure
    Henry Klar Yaggi; Fiscal Year: 2013
    ..The primary analysis will compare each of the active treatment groups to control. A non-inferiority design will be used to assess whether NSO and CPAP are non-inferior to ASV. ..
  2. TGF-Beta in Intimal Hyperplasia after Vascular Bypass
    K Craig Kent; Fiscal Year: 2013
    ..We will show that CTGF is necessary and sufficient for adaptive remodeling and explore the role of collagen type III in this process...
  3. Sex Hormones and Rat Anterior Cruciate Ligament Strength
    William A Romani; Fiscal Year: 2010
    ..These studies are important and they will help direct future studies to identify women at risk for ACL injury and develop novel strategies to prevent their occurrence. ..
  4. Transplantation of a self-assembled corneal substitute
    James D Zieske; Fiscal Year: 2013
    ..Our experiments will test whether placement of a cell-based scaffold results in a serious immune response, and if the scaffold may stimulate scar-free healing. ..
  5. TYPE III COLLAGEN GENE EXPRESSION IN CARTILAGE
    SHERRILL ADAMS; Fiscal Year: 1993
    ..Furthermore, they will provide more extensive analysis of the structure of the type III collagen gene and its regulation than has heretofore been available...
  6. COLLAGEN GENE EXPRESSION DURING SCLERAL MATURATION
    MARK ZORN; Fiscal Year: 1991
    ..The sclera is made largely of collagen types I and III. Collagen type III is less able to resist stretch than is collagen type I...
  7. COLLAGEN GENE EXPRESSION IN CHONDROCYTES IN INFLAMMATION
    MARY GOLDRING; Fiscal Year: 1990
    ..These inflammatory mediators may induce inappropriate repair of cartilage matrix in vivo and these studies should determine whether their effects are mediated primarily at the transcriptional or post-transcriptional level...
  8. LOCALIZATION OF PROCOLLAGENS IN DENTAL TISSUES
    CHARLES LEBLOND; Fiscal Year: 1990
    ..The aim of our work is to utilize immunolabeling for these substances using 5 nm gold particles to determine how they related to the amyloid P core of microfibrils and basotubules...
  9. TYPE III COLLAGEN GENE EXPRESSION IN CARTILAGE
    SHERRILL ADAMS; Fiscal Year: 2007
    ..Finally, these studies will provide unique insights into the regulation of a complex locus which is, in essence, a gene within a gene. ..
  10. COLLAGEN BIOSYNTHESIS BY CULTURED FIBROBLASTS
    Jouni Uitto; Fiscal Year: 1990
    ..The results will also provide us with knowledge highly useful for the development of rationale treatment modalities for these conditions...
  11. FAMILIAL AORTIC ANEURYSM: A MOLECULAR GENETIC ANALYSIS
    Craig Basson; Fiscal Year: 2005
    ..Moreover, characterization of these genes will provide a platform for the development of experimental models of cardiovascular disease and to develop innovative pharmacologic strategies to prevent or to retard aortic aneurysm formation. ..
  12. EXTRACELLULAR MATRIX PRODUCTION BY UTERINE FIBROIDS
    ROMANA NOWAK; Fiscal Year: 1993
    ..human uterine leiomyoma and myometrial expression of a) the extra-cellular matrix proteins collagen Type I, collagen Type III and fibronectin, and b) the matrix-degrading enzymes stromelysin and collagenase. 2...
  13. MUTATIONAL EFFECTS ON COLLAGEN'S STRUCTURE & STABILITY
    TERI KLEIN; Fiscal Year: 2003
    ....
  14. MODEL FOR STUDYING THE CONTRACTILE PROCESS IN HEALING
    H Ehrlich; Fiscal Year: 1992
    ..A combination of cortisone and oral heparin will be tried to modify neovascularization. Reducing neovascularization of wounds should reduce the amount of new connective tissue deposited which should affect the contractile process...
  15. TRANSCRIPTIONAL MECHANISMS OF CARCINOGENESIS
    Jeffrey Holt; Fiscal Year: 1999
    ....
  16. COLLAGEN FOLDING IN PRESENCE OF CIS-TRANS ISOMERASE
    Hans Peter Bachinger; Fiscal Year: 1990
    ....
  17. CONTROL OF COLLAGEN METABOLISM AND CROSSLINKING
    Marcel Nimni; Fiscal Year: 1990
    ..Crosslinked peptides in Descemet's membrane an basement membrane derived from cultured corneal endothelial cells will be labelled, fractioned by 2-D mapping and characterized by tryptic fingerprinting on HPLC...
  18. PEPTIDE INHIBITORS OF EXTRACELLULAR MATRIX PROTEASES
    THOMAS VANAMAN; Fiscal Year: 1993
    ..Positive results (inhibition) would prove the role of the respective collagenase in this pathological condition and suggest the use of collagenase inhibitors as anti-angiogenic drugs...
  19. MESANGIAL MATRIX EXPANSION IN DIABETES--ROLE OF IGF
    Christine Abrass; Fiscal Year: 1992
    ..Definition of those metabolic factors which contribute to he development and progression of mesangial sclerosis should lead to strategies for the prevention of diabetic nephropathy...
  20. MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM
    Allen Samarel; Fiscal Year: 1993
    ....
  21. AQUEOUS OUTFLOW AND STRUCTURAL CORRELATIONS
    Arto Palkama; Fiscal Year: 2003
    ..In the future, this technique may be used to directly monitor outflow and the structural relationships of outflow in the human eye. ..
  22. In Vitro Model of Human Corneal Fibrosis
    JAMES ZIESKE; Fiscal Year: 2009
    ..Studies of human scar formation have been limited by the unavailability of human tissue and culture models. We propose to generate a culture model of corneal scarring using human cells. ..
  23. LUNG FIBROSIS--MECHANISMS OF COLLAGEN GENE EXPRESSION
    Barbara Smith; Fiscal Year: 1992
    ....
  24. Linking Collagen Genotypes to Molecular Phenotypes
    TERI KLEIN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Differential expression of collagen by TGF-b1 & b3
    Stephanie Goldberg; Fiscal Year: 2006
    ..In contrast, fetal wounds heal with scarlessly and with a higher ratio of collagen type III to type 1a1 deposition than in adult wounds...
  26. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  27. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  28. Capillary Electrophoresis Profiling of Tears in Dry Eye
    JEAN JACOB; Fiscal Year: 2006
    ....
  29. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  30. Reactive Oxygen Species Regulate Smooth Muscle Growth
    ROMANA NOWAK; Fiscal Year: 2007
    ..We believe halofuginone may act by inhibiting ROS-dependent signaling pathways in these cells as well as in leiomyoma SMCs. ..
  31. Hypoxia VHL nad HIF in Renal Tumor Development
    Volker Haase; Fiscal Year: 2008
    ..Ultimately they have the potential to create a murine model of VHL associated renal tumors. ..
  32. Endothelial Progenitor Cells: Clinical Correlates and Prognosis in the Community
    Thomas Wang; Fiscal Year: 2009
    ..abstract_text> ..
  33. Molecular Mechanisms of Mesangial Sclerosis
    Christine Abrass; Fiscal Year: 2009
    ..Understanding transcriptional control of LN isoform expression will add new insights into the role that LN plays in normal glomerulogenesis and that becomes disordered in glomerular disease. ..
  34. Antiviral Therapy in African Americans with HCV
    Nezam Afdhal; Fiscal Year: 2005
    ..Specimens of liver tissue and serum will be collected for basic studies on viral resistance. These studies should help determine the best therapy for AA with HCV. ..
  35. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  36. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas J Wang; Fiscal Year: 2010
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..
  37. The Interaction of Mechanical Load and Inflammation in Tendon-Bone Healing
    Scott A Rodeo; Fiscal Year: 2010
    ..The results of our studies will allow a scientific basis for the design of post- operative rehabilitation prescription. ..
  38. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
    ..Identification of these variants may have a significant impact on the public health of asthma patients. ..
  39. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  40. Wayne State University Clinical Translational Science
    Michael Diamond; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. GLOMERULAR LAMININS: STRUCTURE AND FUNCTION
    Christine Abrass; Fiscal Year: 2003
    ....
  42. Collagen-binding proteins in softening of uterine cervix
    Robert Kokenyesi; Fiscal Year: 2003
    ....
  43. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
    ..The results of these studies will provide insight into the processes involved in the success or failure of corneal augmentation and replacement by artificial implants. ..
  44. Biomolecular Mechanics of Collagen Monomers And Fibrils
    Charlotte Phillips; Fiscal Year: 2004
    ....
  45. TSK-2: A NEW ANIMAL MODEL FOR SCLERODERMA
    Paul Christner; Fiscal Year: 2004
    ..abstract_text> ..
  46. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  47. Proteomics and Biomarkers for Hepatocellular Cancer
    Nezam Afdhal; Fiscal Year: 2004
    ..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
  48. Myocardial Fibrosis in Heart Failure in the Elderly
    Eddy Barasch; Fiscal Year: 2004
    ..In addition to improving prediction of outcome of HF in elderly, the findings of this research may aid in designing clinical trials of treatment and prevention targeted to myocardial fibrosis. ..
  49. Proteome Mapping of Heart Failure in Aging
    MARVIN BOLUYT; Fiscal Year: 2005
    ..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
  50. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  51. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  52. STEM CELL THERAPY FOR DISEASES OF BONE IN A MOUSE MODEL
    Christopher Niyibizi; Fiscal Year: 2005
    ..The proposed studies may lead to the development of better treatments for genetic and non-genetic diseases of bone based on BMSCs. ..
  53. Glutathione deficiency & immune dysfunction during aging
    Rui Ming Liu; Fiscal Year: 2006
    ....
  54. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  55. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  56. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  57. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  58. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..