acetic acids

Summary

Summary: Acetic acid and its derivatives which may be formed by substitution reactions. Mono- and di-substituted, as well as halogenated compounds have been synthesized.

Top Publications

  1. ncbi Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and met
    V Syed
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Endocrinology 139:3503-11. 1998
  2. ncbi COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility
    D X Xie
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Science 280:1091-4. 1998
  3. pmc Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure
    Dontamala Suhita
    CEA Cadarache DSV DEVM, Laboratoire des Echanges Membranaires et Signalisation, UMR 163 CNRS CEA, Universite de la Mediterranee, 13108 St Paul lez Durance Cedex, France
    Plant Physiol 134:1536-45. 2004
  4. pmc Bacterial protection of beetle-fungus mutualism
    Jarrod J Scott
    Department of Bacteriology, University of Wisconsin Madison, WI 53706, USA
    Science 322:63. 2008
  5. ncbi Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight
    John D Baxter
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0540, USA
    Trends Endocrinol Metab 15:154-7. 2004
  6. pmc The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production
    Shintaro Munemasa
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Plant Physiol 143:1398-407. 2007
  7. pmc Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses
    Ron A Salzman
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Plant Physiol 138:352-68. 2005
  8. ncbi Exogenous application of methyl jasmonate elicits defenses in Norway spruce (Picea abies) and reduces host colonization by the bark beetle Ips typographus
    Nadir Erbilgin
    Division of Insect Biology Department of Environmental Science, Policy and Management University of California, 140 Mulford Hall, Berkeley, CA, 94720, USA
    Oecologia 148:426-36. 2006
  9. ncbi Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker
    Gary R Klinefelter
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:164-73. 2002
  10. ncbi The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
    Hongtao Zhang
    Institute of Biology, Leiden University, Sylvius Laboratory, PO Box 9505, 2300 RA Leiden, The Netherlands
    Plant J 67:61-71. 2011

Detail Information

Publications234 found, 100 shown here

  1. ncbi Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and met
    V Syed
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Endocrinology 139:3503-11. 1998
    ....
  2. ncbi COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility
    D X Xie
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Science 280:1091-4. 1998
    ..It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination...
  3. pmc Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure
    Dontamala Suhita
    CEA Cadarache DSV DEVM, Laboratoire des Echanges Membranaires et Signalisation, UMR 163 CNRS CEA, Universite de la Mediterranee, 13108 St Paul lez Durance Cedex, France
    Plant Physiol 134:1536-45. 2004
    ..Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells...
  4. pmc Bacterial protection of beetle-fungus mutualism
    Jarrod J Scott
    Department of Bacteriology, University of Wisconsin Madison, WI 53706, USA
    Science 322:63. 2008
    ....
  5. ncbi Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight
    John D Baxter
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0540, USA
    Trends Endocrinol Metab 15:154-7. 2004
    ..Although more study is required, compounds of this class deserve further investigation for treating lipid disorders and obesity...
  6. pmc The coronatine-insensitive 1 mutation reveals the hormonal signaling interaction between abscisic acid and methyl jasmonate in Arabidopsis guard cells. Specific impairment of ion channel activation and second messenger production
    Shintaro Munemasa
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Plant Physiol 143:1398-407. 2007
    ....
  7. pmc Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses
    Ron A Salzman
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Plant Physiol 138:352-68. 2005
    ....
  8. ncbi Exogenous application of methyl jasmonate elicits defenses in Norway spruce (Picea abies) and reduces host colonization by the bark beetle Ips typographus
    Nadir Erbilgin
    Division of Insect Biology Department of Environmental Science, Policy and Management University of California, 140 Mulford Hall, Berkeley, CA, 94720, USA
    Oecologia 148:426-36. 2006
    ..The increased amount of terpenoid resin present in methyl jasmonate-treated bark could be directly responsible for the observed decrease in I. typographus colonization and reproduction...
  9. ncbi Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker
    Gary R Klinefelter
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:164-73. 2002
    ..84. Using this exposure paradigm, the no-observed-effect level for BCA is less than 8 mg/kg. Moreover, SP22 may be useful in predicting compromised fertility after exposure to by-products of drinking water disinfection...
  10. ncbi The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
    Hongtao Zhang
    Institute of Biology, Leiden University, Sylvius Laboratory, PO Box 9505, 2300 RA Leiden, The Netherlands
    Plant J 67:61-71. 2011
    ....
  11. ncbi Myrosinases, TGG1 and TGG2, redundantly function in ABA and MeJA signaling in Arabidopsis guard cells
    Mohammad Mahbub Islam
    Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama, Japan
    Plant Cell Physiol 50:1171-5. 2009
    ..A model is discussed in which two myrosinases redundantly function downstream of ROS production and upstream of cytosolic Ca(2+) elevation in ABA and MeJA signaling in guard cells...
  12. ncbi Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions
    Alessandra Devoto
    School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK
    Plant Mol Biol 58:497-513. 2005
    ..These results indicate that COI1 plays a pivotal role in wound- and JA signalling...
  13. ncbi Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. Barbera cell cultures
    Annalisa Tassoni
    Department of Biology e s and Interdepartmental Centre for Biotechnology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy
    New Phytol 166:895-905. 2005
    ..Gel analysis was performed on control and 10 microm MeJA treated cell suspensions. Results showed an up-regulation of the stilbene synthase demonstrating that MeJA stimulated the synthesis ex-novo of this protein...
  14. pmc Comparisons of LIPOXYGENASE3- and JASMONATE-RESISTANT4/6-silenced plants reveal that jasmonic acid and jasmonic acid-amino acid conjugates play different roles in herbivore resistance of Nicotiana attenuata
    Lei Wang
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany
    Plant Physiol 146:904-15. 2008
    ....
  15. pmc Laser microdissection of conifer stem tissues: isolation and analysis of high quality RNA, terpene synthase enzyme activity and terpenoid metabolites from resin ducts and cambial zone tissue of white spruce (Picea glauca)
    Eric Abbott
    Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada
    BMC Plant Biol 10:106. 2010
    ..These tissues are difficult to isolate for tissue-specific molecular and biochemical characterization and are thus good targets for application of LMD...
  16. ncbi Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine
    Gary J Grover
    Metabolic and Cardiovascular Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey 08534, USA
    Endocrinology 145:1656-61. 2004
    ..Therefore, selective TRbeta activation may be a potentially usefully treatment for obesity and reduction of low density lipoprotein cholesterol and reduction of the atherogenic risk factor lipoprotein (a)...
  17. pmc Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
    Lisen Johansson
    Metabolism Unit, Center for Metabolism and Endocrinology, Department of Medicine, and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum, Karolinska Institute at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:10297-302. 2005
    ..Use of TRbeta and uptake selective agonists such as GC-1 should be further explored as a strategy to improve lipid metabolism in dyslipoproteinemia...
  18. pmc Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring
    Naomi D Elkin
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Toxicol Sci 117:439-48. 2010
    ....
  19. ncbi Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment
    Ngoc Ha Nguyen
    Program in Chemistry and Chemical Biology, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    J Med Chem 45:3310-20. 2002
    ..One mechanism for antagonism appears to be the ability of NH-3 to block TR-coactivator interactions. NH-3 will be a useful pharmacological tool for further study of T(3) signaling and TR function...
  20. pmc Metabolic fate of jasmonates in tobacco bright yellow-2 cells
    Agnieszka Swiatek
    Laboratory of Plant Physiology and Biochemistry, Department of Biology, University of Antwerp, B 2610 Antwerp, Belgium
    Plant Physiol 135:161-72. 2004
    ..Upon hydrolysis of methyl jasmonate to jasmonic acid, a similar set of conversions occurs. In contrast to jasmonic acid, none of its derivatives interfere with the G2/M transition in synchronized tobacco Bright Yellow-2 cells...
  21. ncbi Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids
    J Laitinen
    Kuopio Regional Institute of Occupational Health, P O Box 93, FI 70701, Kuopio, Finland
    Toxicol Lett 156:117-26. 2005
    ..2-alkoxyethanols, and their most hazardous similarity is their ability to metabolize to the 2-(2-alkoxyethoxy)acetic acids. In the present study, floor lacquerers' (n = 22) inhalation and total exposure to 2-(2-alkoxy)ethoxyethanols ..
  22. ncbi Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1
    J David Furlow
    Section of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616 8519, USA
    J Biol Chem 279:26555-62. 2004
    ..The effectiveness of GC-1 in inducing tail resorption and tail gene expression correlates with increasing TRbeta levels. These results illustrate the utility of subtype selective ligands as probes of nuclear receptor function in vivo...
  23. ncbi Cloning and expression of a tomato cDNA encoding a methyl jasmonate cleaving esterase
    Christiane Stuhlfelder
    Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Germany
    Eur J Biochem 271:2976-83. 2004
    ..Moreover, when tested in methyl jasmonate- and elicitor-treated cell suspension cultures, transcript levels were found to decrease, indicating that this particular enzyme might be a regulator of jasmonate signalling...
  24. ncbi Purification and partial amino acid sequences of an esterase from tomato
    Christiane Stuhlfelder
    Julius von Sachs Institute for Biosciences, Pharmaceutical Biology, University of Wurzburg, Julius von Sachs Platz 2, Germany
    Phytochemistry 60:233-40. 2002
    ..Sequence alignment of these fragments showed high homologies to certain plant esterases and hydroxynitrile lyases that belong to the alpha/beta hydrolase fold protein superfamily...
  25. ncbi Hormone selectivity in thyroid hormone receptors
    R L Wagner
    Department of Biochemistry, University of California, San Francisco, California 94143, USA
    Mol Endocrinol 15:398-410. 2001
    ..These results suggest a strategy for development of subtype-specific compounds involving modifications of the ligand at the 1-position...
  26. ncbi The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats
    Fatima R S Freitas
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Bone Miner Res 20:294-304. 2005
    ..Our findings indicate that T3 exerts some essential effects on bone development that are mediated by TRbeta1...
  27. ncbi A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula
    Hideyuki Suzuki
    Plant Biology Division, The Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Plant J 32:1033-48. 2002
    ..Sterol composition remained unaffected by jasmonate treatment. Molecular verification of induction of the triterpene pathway in a cell culture system provides a new tool for saponin pathway gene discovery by DNA array-based approaches...
  28. pmc UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants
    Youli Yao
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Plant Cell 23:3842-52. 2011
    ..Finally, various forms of stress resulting in the formation of necrotic lesions also generate a volatile signal that leads to genomic instability...
  29. ncbi Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    FASEB J 17:1171-3. 2003
    ..These findings indicate that the balance between the production of LTB4 and ATL modulates PMN recruitment/function and gastric mucosal responses to aspirin...
  30. ncbi Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters
    Yi Xia
    Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA
    Bioorg Med Chem Lett 13:2891-3. 2003
    2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines...
  31. ncbi Methyl jasmonate does not induce changes in Eucalyptus grandis leaves that alter the effect of constitutive defences on larvae of a specialist herbivore
    M L Henery
    School of Botany and Zoology, The Australian National University, Canberra, NSW, 0200, Australia
    Oecologia 156:847-59. 2008
    ....
  32. ncbi Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
    Maxim Moreau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    J Rheumatol 33:1176-83. 2006
    ..The effect of drug treatment on the expression and activity of metalloproteases in the OA cartilage was also studied...
  33. ncbi Sertoli cell modulates MAA-induced apoptosis of germ cells throughout voltage-operated calcium channels
    Fortunata Barone
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    FASEB J 18:353-4. 2004
    ....
  34. ncbi N-acetylcysteine prevents MAA induced male germ cell apoptosis: role of glutathione and cytochrome c
    A V S Kondala Rao
    National Institute of Immunology, Aruna Asaf Ali Marg, 110067, New Delhi, India
    FEBS Lett 527:133-7. 2002
    ..Replenishment of glutathione by pretreatment of the animals with the antioxidant N-acetylcysteine prior to MAA treatment could prevent the release of cytochrome c, DNA fragmentation and cell death...
  35. ncbi The laminin binding protein p40 is involved in inducing limb abnormality of mouse fetuses as the effects of methoxyacetic acid treatment
    Aceng Ruyani
    Departemen Biologi, Institut Teknologi Bandung Jl, Ganesha No 10, Labtek XI, Bandung 40132, Indonesia
    Toxicol Sci 75:148-53. 2003
    ..The identity was further verified by Western blotting with an antibody against the 67 kDa LBP. The results suggest that MAA treatment to pregnant mice downregulates the LBP-p40 in the forelimb buds...
  36. ncbi A teratoproteomics analysis: heat shock protein 70 is upregulated in mouse forelimb bud by methoxyacetic acid treatment
    Aceng Ruyani
    Program Studi Pendidikan Biologi, Universitas Bengkulu, Jalan Raya Kandang Limun, Bengkulu, Indonesia
    Birth Defects Res A Clin Mol Teratol 73:517-21. 2005
    ..Limb abnormalities are caused mainly by extensive cell death in the mesoderm of the limb plate. This investigation focused on identifying a protein that is linked with mouse limb teratogenicity...
  37. pmc Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plants
    Cha Young Kim
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Plant Cell 15:2707-18. 2003
    ..These results suggest that the induction of ethylene but not JA/MJ is involved in plant defense responses mediated by the NtMEK2-SIPK/WIPK pathway...
  38. pmc The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling
    Derek V Henley
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1702-6. 2009
    ..The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression...
  39. ncbi High throughput sequencing technology reveals that the taxoid elicitor methyl jasmonate regulates microRNA expression in Chinese yew (Taxus chinensis)
    Deyou Qiu
    Department of Molecular Biology, The Research Institute of Forestry, Chinese Academy of Forestry, Beijing, China
    Gene 436:37-44. 2009
    ....
  40. ncbi Transcription factor MYC2 is involved in priming for enhanced defense during rhizobacteria-induced systemic resistance in Arabidopsis thaliana
    Maria J Pozo
    Graduate School Experimental Plant Sciences, Plant Microbe Interactions, Institute of Environmental Biology, Faculty of Science, Utrecht University, PO Box 800 56, 3508 TB, Utrecht, The Netherlands
    New Phytol 180:511-23. 2008
    ..Together, these results pinpoint MYC2 as a potential regulator in priming for enhanced JA-responsive gene expression during rhizobacteria-mediated ISR...
  41. ncbi A novel R2R3 MYB transcription factor NtMYBJS1 is a methyl jasmonate-dependent regulator of phenylpropanoid-conjugate biosynthesis in tobacco
    Ivan Galis
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Plant J 46:573-92. 2006
    ....
  42. pmc The jasmonate signal pathway
    John G Turner
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Plant Cell 14:S153-64. 2002
  43. pmc Arabidopsis vegetative storage protein is an anti-insect acid phosphatase
    Yilin Liu
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    Plant Physiol 139:1545-56. 2005
    ..Collectively, we conclude that AtVSP2 is an anti-insect protein and that its defense function is correlated with its acid phosphatase activity...
  44. ncbi Overexpression of rice WRKY89 enhances ultraviolet B tolerance and disease resistance in rice plants
    Haihua Wang
    Department of Plant Pathology, State Key Laboratory of Agrobiotechnology, China Agricultural University, Yuanmenyuan West Rd 2, Beijing 100094, China
    Plant Mol Biol 65:799-815. 2007
    ..These results suggest that OsWRKY89 plays an important role in response to biotic and abiotic stresses...
  45. ncbi Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures
    Jian Zhao
    Laboratory of Forest Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Exp Bot 54:647-56. 2003
    ..These observations suggest that Ca(2+) and G-proteins may mediate elicitor signals to the jasmonate pathway, and the jasmonate signalling pathway may then lead to the production of beta-thujaplicin...
  46. pmc Impact of methoxyacetic acid on mouse Leydig cell gene expression
    Gargi Bagchi
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, MA 02215, USA
    Reprod Biol Endocrinol 8:65. 2010
    ..This study investigates the impact of MAA on gene expression in testicular Leydig cells, which play a critical role in germ cell survival and male reproductive function...
  47. ncbi Amide derivatives of [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as potential analgesic and anti-inflammatory compounds
    Erden Banoglu
    Department of Pharmaceutical Chemistry, Division of Pharmaceutical Sciences, Faculty of Pharmacy, Gazi University, 06330 Etiler Ankara, Turkey
    Arch Pharm (Weinheim) 336:251-7. 2003
    ..of the carboxylate moiety into amides in [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids. We have tested the analgesic and anti-inflammatory activities of the synthesized compounds in vivo by using p-..
  48. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
    ..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
  49. ncbi Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis
    Patrick Marcouiller
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec
    J Rheumatol 32:704-12. 2005
    ....
  50. ncbi Terpenoid biosynthesis and specialized vascular cells of conifer defense
    Katherine G Zulak
    Michael Smith Laboratories, University of British Columbia, Vancouver BC V6T 1Z4, Canada
    J Integr Plant Biol 52:86-97. 2010
    ..Formation of these resin ducts de novo in the cambium zone and developing xylem, following insect attack or treatment of trees with methyl jasmonate, is a unique feature of the induced defense of long-lived conifer trees...
  51. ncbi Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in rats
    Michael G Wade
    Systemic Toxicology and Pharmacokinetics Section, Environmental Health Sciences Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Biol Reprod 78:822-31. 2008
    ..Our results indicate that exposure to MAA causes increased acetylation of core histones in several testis germ cell populations, including those in prophase of meiosis, a large proportion of which die rapidly following this treatment...
  52. ncbi Roles of AtTPC1, vacuolar two pore channel 1, in Arabidopsis stomatal closure
    Mohammad Mahbub Islam
    Graduate School of Natural Science and Technology, Okayama University, 1 1 1 Tsushima naka, Okayama, 700 8530 Japan
    Plant Cell Physiol 51:302-11. 2010
    ....
  53. pmc Insect-induced conifer defense. White pine weevil and methyl jasmonate induce traumatic resinosis, de novo formed volatile emissions, and accumulation of terpenoid synthase and putative octadecanoid pathway transcripts in Sitka spruce
    Barbara Miller
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Plant Physiol 137:369-82. 2005
    ..Findings of insect- and MeJA-induced accumulation of allene oxide synthase-like and allene oxide cyclase-like transcripts are discussed in the context of traumatic resinosis and induced volatile emissions in this gymnosperm system...
  54. ncbi Impact of water stagnation in residential cold and hot water plumbing on concentrations of trihalomethanes and haloacetic acids
    Annick Dion-Fortier
    Civil Engineering Department, Universite Laval, Quebec City, Canada G1K 7P4
    Water Res 43:3057-66. 2009
    ..The results are useful to identify methods of indoor water use that minimize population exposure to DBPs and improve DBP exposure assessment for epidemiological studies...
  55. pmc Methyl jasmonate-elicited herbivore resistance: does MeJA function as a signal without being hydrolyzed to JA?
    Jinsong Wu
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoll Strasse 8, Jena, Germany
    Planta 227:1161-8. 2008
    ..From these results, we conclude that the resistance elicited by MeJA treatment is directly elicited not by MeJA but by its de-methylated product, JA...
  56. pmc The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration
    J Michael Wright
    Office of Research and Development, National Center for Environmental Assessment, U S Environmental Protection Agency, 26 W Martin Luther King Drive MS 90, Cincinnati, OH 45268, USA
    Environ Health Perspect 112:920-5. 2004
    ..These data also suggest a relationship between fetal development indices and mutagenic activity independent of exposure to trihalomethanes, haloacetic acids, and MX...
  57. pmc Interactions of methoxyacetic acid with androgen receptor
    Gargi Bagchi
    Division of Cell and Molecular Biology, Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Toxicol Appl Pharmacol 238:101-10. 2009
    ..Deregulation of these genes may alter androgen synthesis and action in a manner that contributes to MAA-induced testicular toxicity...
  58. pmc Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell cultures
    Mohamed A Farag
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Physiol 146:387-402. 2008
    ....
  59. ncbi Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    Y Yukimune
    Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd, Yamaguchi, Japan
    Nat Biotechnol 14:1129-32. 1996
    ..These results suggest that these two regions of methyl jasmonate are important for promoting the production of paclitaxel and related taxanes in Taxus cell cultures...
  60. pmc Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stems
    Diane Martin
    Max Planck Institute for Chemical Ecology, Carl Zeiss Promenade 10, 07745 Jena, Germany
    Plant Physiol 129:1003-18. 2002
    ....
  61. ncbi Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid
    T Jindo
    Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 29:607-16. 2001
    ..Westem blotting and immunocytochemistry confirmed this finding. The data we present implicate kinase activities in the pathogenesis of this lesion and suggest the involvement of Sertoli cells...
  62. ncbi Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 21:237-76. 2002
    ..Based on the high multiples of human exposure required to produce effects in male rats, DBA should not be identified as a human reproductive or developmental risk...
  63. ncbi Targeted proteomics using selected reaction monitoring reveals the induction of specific terpene synthases in a multi-level study of methyl jasmonate-treated Norway spruce (Picea abies)
    Katherine G Zulak
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 60:1015-30. 2009
    ....
  64. ncbi Induction of anatomically based defense responses in stems of diverse conifers by methyl jasmonate: a phylogenetic perspective
    J W Hudgins
    School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
    Tree Physiol 24:251-64. 2004
    ..Co-evolution of conifer defensive strategies and bark beetle pests is discussed...
  65. ncbi Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase
    Jenny Fäldt
    Biotechnology Laboratory, Department of Botany and Department of Forest Sciences, University of British Columbia, 6174 University Boulevard, Vancouver V6T 1Z3, BC Canada
    Plant Mol Biol 51:119-33. 2003
    ..3-Carene is a characteristic monoterpene of constitutive and induced oleoresin defense of Norway spruce and other members of the Pinaceae...
  66. pmc Modulation of MAA-induced apoptosis in male germ cells: role of Sertoli cell P/Q-type calcium channels
    Fortunata Barone
    Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Rome, Italy
    Reprod Biol Endocrinol 3:13. 2005
    ..The results obtained demonstrate that Sertoli cells modulate germ cell apoptosis induced by methoxyacetic acid also throughout the P/Q-type VOCC's...
  67. ncbi Ontogeny constrains systemic protease inhibitor response in Nicotiana attenuata
    N M van Dam
    Max-Planck-Institute for Chemical Ecology, Carl-Zeiss-Promenade 10, D-07745 Jena, Germany
    J Chem Ecol 27:547-68. 2001
    ..Interestingly, by the time plants reach the flowering stage, they had lost the ability to increase PI levels after MeJA treatment. We concluded that plant ontogeny constrains both constitutive and inducible PI production in N. attenuata...
  68. ncbi Methyl jasmonate treatment of mature Norway spruce (Picea abies) trees increases the accumulation of terpenoid resin components and protects against infection by Ceratocystis polonica, a bark beetle-associated fungus
    Gazmend Zeneli
    Max Planck Institute for Chemical Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
    Tree Physiol 26:977-88. 2006
    ..The observed chemical and anatomical changes in response to MJ treatment were correlated with increased resistance to C. polonica, suggesting that terpenoid oleoresin may function in defense against this pathogen...
  69. ncbi Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis
    Emily Hanson Scofield
    University of Georgia, Department of Environmental Health Science, Athens, GA 30602 2102, USA
    Reprod Toxicol 22:718-24. 2006
    ..These results suggest that effects of DEGME and EGME are the result of generalized toxicity, but their metabolite MAA induces mitochondrial-mediated apoptosis during in vitro chondrogenesis...
  70. ncbi Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies)
    Axel Schmidt
    Max Planck Institute for Chemical Ecology, Department of Biochemistry, Hans Knoll Strasse 8, D 07745 Jena, Germany
    Phytochemistry 69:49-57. 2008
    ..Hence these proteins may not be involved in monoterpene formation and could conceivably form products in addition to GPP in planta...
  71. ncbi Immunofluorescence localization of levopimaradiene/abietadiene synthase in methyl jasmonate treated stems of Sitka spruce (Picea sitchensis) shows activation of diterpenoid biosynthesis in cortical and developing traumatic resin ducts
    Katherine G Zulak
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Phytochemistry 71:1695-9. 2010
    ..Overall, the results of this work improve our understanding of spatial and temporal patterns of induced diterpene resin acid biosynthesis in conifers...
  72. pmc Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway
    Chuanyou Li
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 130:494-503. 2002
    ..Tight linkage of Def-1 to a T-DNA insertion harboring the maize (Zea mays) Dissociation transposable element suggests a strategy for directed transposon tagging of the gene...
  73. ncbi Methyl jasmonate and oxalic acid treatment of Norway spruce: anatomically based defense responses and increased resistance against fungal infection
    Paal Krokene
    Norwegian Forest and Landscape Institute, P O Box 155, 1431 As, Norway
    Tree Physiol 28:29-35. 2008
    ..In conclusion, MJ treatment of Norway spruce appears to have practical potential as a tool for increasing plant resistance to fungal infection, but with a modest reduction in sapwood growth...
  74. ncbi Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites
    Jochem Louisse
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Toxicol Appl Pharmacol 245:236-43. 2010
    ..Together, the results presented indicate that a decrease of the pH(i) may be the mechanism of embryotoxicity of the alkoxyacetic acid metabolites of the glycol ethers...
  75. ncbi Jasmonic acid does not mediate root growth responses to wounding in Arabidopsis thaliana
    Lilian Schmidt
    Institut Phytosphäre ICG 3, Forschungszentrum Julich GmbH, Julich, Germany
    Plant Cell Environ 33:104-16. 2010
    ..thaliana. Overall, the results demonstrate that the reaction of root growth to herbivore-induced JA signalling differs among species, which is discussed in the context of different ecological defence strategies among species...
  76. pmc Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruce
    Diane M Martin
    Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
    Plant Physiol 132:1586-99. 2003
    ..Based on precedents in other species, the induced emission of terpenes from Norway spruce foliage may have ecological and physiological significance...
  77. ncbi Jasmonate-induced nicotine formation in tobacco is mediated by tobacco COI1 and JAZ genes
    Tsubasa Shoji
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, 630 0192 Japan
    Plant Cell Physiol 49:1003-12. 2008
    ..These results indicate that jasmonate-triggered, COI1-mediated degradation of JAZ repressors activates transcriptional regulation of nicotine biosynthesis genes in tobacco roots...
  78. ncbi Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether
    Akira Takagi
    Department of Medical Technology, Nagoya University School of Health Sciences, Daiko minami 1 1 20, Higashi ku, Nagoya 461 8673, Japan
    Ind Health 40:371-4. 2002
    ..Caspase-3 enzyme activity, the effector of the apoptotic process, was greatly enhanced with MALD treatment. The inhibitor of caspase-3 repressed cell death induced with MALD as well as MAA...
  79. ncbi Haloacid induced alterations in fertility and the sperm biomarker SP22 in the rat are additive: validation of an ELISA
    Emilie H Kaydos
    North Carolina State University, Department of Environmental and Molecular Toxicology, Raleigh, North Carolina 27606, USA
    Toxicol Sci 81:430-42. 2004
    ..The correlation between SP22 levels by ELISA and fertility was r(2) = 0.72 compared to 0.82 for SP22 levels by 2D SDS-PAGE and fertility, validating SP22 quantitation by ELISA...
  80. ncbi Coordinated transcriptional regulation of the divinyl ether biosynthetic genes in tobacco by signal molecules related to defense
    Alessandro Fammartino
    University of Turin, DiVaPRA Plant Pathology, Via L da Vinci 44, I 10095 Grugliasco TO, Italy
    Plant Physiol Biochem 48:225-31. 2010
    ..Our data suggest that, in tobacco, DVE biosynthesis is cross-regulated by jasmonates, and by other hormonal and signal molecules such as ethylene and SA...
  81. pmc Methyl jasmonate-induced ethylene production is responsible for conifer phloem defense responses and reprogramming of stem cambial zone for traumatic resin duct formation
    J W Hudgins
    School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
    Plant Physiol 135:2134-49. 2004
    ..The results also indicate a central role of ray parenchyma in ethylene-induced defense...
  82. ncbi Behavior of trihalomethanes and haloacetic acids in a drinking water distribution system
    Manuel J Rodriguez
    École supérieure d aménagement du territoire, et développement régional ESAD, Universite Laval, 1624 Pavillon Savard, Que, Canada G1K 7P4
    Water Res 38:4367-82. 2004
    ..The results used in the portrait of CDBP behavior are also relevant in terms of exposure assessment for future epidemiological studies on human reproductive outcomes in the region...
  83. pmc Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition
    Michelle S Jansen
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:7199-204. 2004
    ..Furthermore, our study highlights the need to structure future screening programs to identify additional hormone sensitizers...
  84. ncbi Local photolysis using tapered quartz fibres
    C Eberius
    Physiologisches Institut, , Humboldtallee 23, , Germany
    Pflugers Arch 443:323-30. 2001
    ..Site and timing of photolysis can be chosen independently from other experimental parameters. As an application example we show the spatially heterogeneous distribution of Ca2+-dependent Cl- channels in olfactory receptor neurons...
  85. ncbi Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii
    Dezene P W Huber
    Michael Smith Laboratories and Departments of Botany and Forest Sciences, University of British Columbia, 301 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
    Phytochemistry 66:1427-39. 2005
    ....
  86. ncbi Plant-plant signaling: application of trans- or cis-methyl jasmonate equivalent to sagebrush releases does not elicit direct defenses in native tobacco
    Catherine A Preston
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology Jena, Germany
    J Chem Ecol 30:2193-214. 2004
    ..We conclude that volatile MeJA, either trans- or cis-, when applied at levels consistent with those released by sagebrush does not elicit direct defenses in N. attenuata...
  87. ncbi Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation
    Serenella Rotondo
    Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Italy
    Eur J Pharmacol 488:79-83. 2004
    ..These results indicate that, at clinically relevant concentrations, licofelone exerts a potent antiplatelet effect mediated by the inhibition of cyclooxygenase-1 activity...
  88. ncbi Therapeutic effect of transcatheter arterial chemoembolization and percutaneous injection of acetic acids on primary liver cancer
    Hong Bin Chen
    Department of Gastroenterology, Sanming Municipal First Hospital, Sanming 365000, China
    Hepatobiliary Pancreat Dis Int 3:55-7. 2004
    ..of present research was to study the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous injection of chemical agents and acetic acids in the treatment of patients with primary liver cancer (PLC).
  89. ncbi The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 34:527-38. 2004
    ....
  90. ncbi Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain
    Jimena Manzano
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain
    Endocrinology 144:5480-7. 2003
    ..However, in the caudate, RC3 and Rhes are expressed in the same cells, and therefore, they may represent specific gene responses linked to specific thyroid hormone receptor isoforms...
  91. ncbi COX-LOX inhibition: current evidence for an emerging new therapy
    M M Skelly
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Int J Clin Pract 57:301-4. 2003
    ..This review examines the hypothesis that licofelone is an effective anti-inflammatory agent that does not cause peptic damage...
  92. ncbi Jasmonic acid influences mycorrhizal colonization in tomato plants by modifying the expression of genes involved in carbohydrate partitioning
    Miriam Tejeda-Sartorius
    Unidad de Biotecnología e Ingeniería Genética de Plantas Cinvestav Campus Guanajuato, Km 9 6 del Libramiento Norte Carretera Irapuato León, Apartado Postal 629, C P 36821, Irapuato, Guanajuato, Mexico
    Physiol Plant 133:339-53. 2008
    ..The significant colonization increase observed in mycorrhizal spr2 plants supplied with exogenous methyl jasmonate supports its role as a positive regulator of the symbiosis...
  93. ncbi Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function
    Serenella Rotondo
    G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro 66030, Italy
    Eur J Pharmacol 453:131-9. 2002
    ..The coexistence within the same molecule of a wide spectrum of anti-inflammatory properties is of interest...
  94. ncbi Methoxyacetic acid disregulation of androgen receptor and androgen-binding protein expression in adult rat testis
    Oscar M Tirado
    Unitat de Recerca Biomedica, Hospital Materno Infantil Vall d Hebron, Barcelona, Spain
    Biol Reprod 68:1437-46. 2003
    ..It is still unclear whether MAA elicits a proapoptotic signal from Sertoli cells or diminishes a prosurvival signal required by germ cells downstream to altering AR and ABP expression in a stage-specific fashion...
  95. ncbi Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy
    Angeles Sánchez-Sampedro
    Department of Plant Physiology, Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain
    J Biotechnol 130:133-42. 2007
    ..The results obtained in this study will permit in the future to identify candidate components of the signalling pathway involved in the stimulation of the constitutive pathway of silymarin...
  96. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    ..This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states...
  97. ncbi Characterization of salicylic acid-induced genes in Chinese cabbage
    Y S Park
    Division of Life Sciences, Chungbuk National University, 360 763 Cheongju, Korea
    Plant Cell Rep 21:1027-34. 2003
    ..tomato, a nonhost pathogen that elicits a hypersensitive response in Chinese cabbage. None of these four genes, however, was strongly induced by methyl jasmonate or by ethylene...
  98. ncbi Methyl jasmonate induces defense responses in grapevine and triggers protection against Erysiphe necator
    Assia Belhadj
    Laboratoire de Mycologie et Biotechnologie Végétale, EA 3675, Universite Victor Segalen Bordeaux 2, UFR Sciences Pharmaceutiques, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Agric Food Chem 54:9119-25. 2006
    ..On the basis of these original results, MeJA can therefore act as an efficient elicitor in an alternative strategy of grapevine protection...
  99. ncbi Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition
    Yosabeth Paredes
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 46:1804-12. 2002
    ....
  100. ncbi Effect of methyl jasmonate in combination with carbohydrates on gene expression of PR proteins, stilbene and anthocyanin accumulation in grapevine cell cultures
    Assia Belhadj
    Groupe d Etude des Substances Végétales à Activité Biologique, EA 3675, ISVV, Universite Victor Segalen Bordeaux 2, UFR Sciences Pharmaceutiques, Bordeaux Cedex, France
    Plant Physiol Biochem 46:493-9. 2008
    ..Methyl jasmonate treatment might be an efficient natural strategy to protect grapevine berries in vineyard...
  101. ncbi [The effect of gabapentin and gabapentin-lactam on retinal ganglion cell survival. Situation after acute retinal ischemia in animal models]
    T Jehle
    Neurologische Universitatsklinik Freiburg, Klinische Neuropharmakologie
    Ophthalmologe 98:237-41. 2001
    ..What are the effects of the antiepileptic drug gabapentin, for which antiglutamatergic effects have been described, and the new substance gabapentin-lactam (GBP-L) on retinal ganglion cell survival after retinal ischemia?..

Research Grants62

  1. NOVEL PALLADIUM CATALYZED SYNTHESES OF INDOLE ALKALOIDS
    BJORN SODERBERG; Fiscal Year: 2001
    ..routes to compounds having an indole nucleus such as 2-fluoro-, 3-fluoro-, and 2,3-difluoroindoles, indole-2-acetic acids, indole-3- acetic acids, indole-3-acetonitriles, tryptamines, beta-carbolines, 1,2,3,4-tetrahydro-beta-..
  2. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2009
    ..Lactobacilli acidify the vagina to pH~4 by secreting lactic and acetic acids. At this pH these acids can rapidly inactivate pathogens by permeating cell and bacterial membranes, but these ..
  3. IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESIS
    STEVEN PODOS; Fiscal Year: 1980
    ..Many families of compounds inhibit prostaglandin synthesis such as the indole acetic acids, arylacetic acids, anthranilic acids, and pyrazolones...
  4. H-BONDS AND PROTON TRANSFER IN MODEL PIGMENT CHROMOPHORE
    PAUL BLATZ; Fiscal Year: 1990
    ..to be studied are: i) donor reagents such as phenol, substituted phenols, acetic acid and chloro substituted acetic acids, ii) selected solvents such as hydrocarbons and chlorohydrocarbons, and iii) changing temperature...
  5. CONTROLLED RELEASE OF MACROMOLECULES
    Robert Langer; Fiscal Year: 2007
    ..polymers such as modified poly(ethylene imines), poly(beta-amino esters), and polylysine graft imidizole acetic acids. Despite progress by us and others, existing non-viral delivery systems are far less efficient than viral ..
  6. New Ligands for Radioimmunotherapy and MRI of Cancer
    Hyun Soon Chong; Fiscal Year: 2006
    ..The results of the proposed research will contribute to the development of better drugs for both MRI and RIT, which will greatly enhance clinical exploration of both modalities, and directly benefit cancer patients. ..
  7. Phase III Trial of Minocycline in ALS-II Data Center
    Robert Miller; Fiscal Year: 2007
    ..The details of data management are described, including the methods for quality control, security and information technology. Finally, the analytic plan is described in full. ..
  8. NADPH P450 REDUCTASE--THYROID HORMONE REGULATION
    David Waxman; Fiscal Year: 2002
    ....
  9. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2004
    ..Overall, this: exploratory: study may open the door for the use of iron chelator nanoparticle systems to target diseased organs for iron chelation therapy. ..
  10. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  11. LIGAND PHARMACOLOGY OF ESTROGEN RECEPTORS
    Thomas Scanlan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  12. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  13. Free Iron, Estrogen and Postmenopausal Osteoporosis
    Gang Liu; Fiscal Year: 2002
    ..Moreover, this new approach will permit the reevaluation of the role of estrogen and will expedite the development of novel pharmaceutical agents for the prevention or treatment of osteoporosis. ..
  14. Intranasal Methamphetamine: A Pharmacotherapy Model
    Carl Hart; Fiscal Year: 2009
    ....
  15. Drug Effects on Behavior: Workplace Implications
    Carl Hart; Fiscal Year: 2008
    ..Together, the data from the proposed studies will have substantial public health impact and will serve both educational and public policy functions. ..
  16. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Mechanisms of H pylori-Induced Hypochlorhydria
    Adam Smolka; Fiscal Year: 2008
    ..pylori strain identity, and anatomic site of infection. These studies will establish the mechanistic basis of H. pylori-induced gastric hypochlorhydria, and add to the understanding of H. pylori pathophysiology. ..
  18. THYROID HORMONE CONTROL OF A GENE EXPRESSION NETWORK
    J Furlow; Fiscal Year: 2008
    ..abstract_text> ..
  19. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMEN
    Hadine Joffe; Fiscal Year: 2007
    ..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
  21. SMART: Improving Detection & Outcome of Psychiatric Comorbidity in Drug Treatment
    Carlos Blanco; Fiscal Year: 2010
    ..abstract_text> ..
  22. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  23. Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention Trials
    Charles Bowden; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Emory Conte Center for the Neuroscience of Mental Disorders
    Becky Kinkead; Fiscal Year: 2008
    ..abstract_text> ..
  25. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  26. Development of Selective Nanoporous Sorbents for Radionuclide Decorporation
    Charles Timchalk; Fiscal Year: 2008
    ..abstract_text> ..
  27. MUTATION ANALYSIS OF THYROID HORMONE FUNCTION
    John Baxter; Fiscal Year: 2009
    ..These studies should provide substantial insight into TR function that is relevant for understanding TR action, mechanism of action of other NRs, regulation of gene expression and pharmaceutical design. ..
  28. BRANCHED CHAIN AMINO ACID METABOLISM
    SUSAN HUTSON; Fiscal Year: 2008
    ..Results from this study will provide new insights into the role(s) played by BCAAs and high protein diets in weight loss and energy expenditure. ..
  29. PROTEIN KINASE C IN THE LENS
    DOLORES JEAN TAKEMOTO; Fiscal Year: 2010
    ..Activation of these enzymes, using targeted drugs, could prevent or delay ocular damage during oxidative insult or ischemia. ..
  30. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..abstract_text> ..
  31. Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for Depression
    Carlos Blanco; Fiscal Year: 2010
    ..abstract_text> ..
  32. Mixture Toxicity - Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2008
    ..Environmental releases of these chemicals are possible, which could also affect public health. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  33. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  34. Long Term Toxicity of Di- and Tri-Chloroacetate
    Ezdihar Hassoun; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. Selective Modulation of Thyroid Receptor Action
    John Baxter; Fiscal Year: 2007
    ..This study will expand our understanding of selective TR modulation in specific and NR action in general. ..
  36. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2004
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  37. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2004
    ..We feel that an understanding of the mechanism of this integration is a prerequisite to obtaining knowledge on the mechanisms by which airway neurophysiology is regulated in health and disregulated in disease. ..
  38. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
    ....
  39. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  40. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2003
    ..Awards will be made without regard to gender, race or ethnicity or disability. ..
  41. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2003
    ..abstract_text> ..
  42. Multidiscipli. GCRC-Mentorship Program in Womens Health
    Lorraine Fitzpatrick; Fiscal Year: 2003
    ..abstract_text> ..
  43. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2002
    ..Awards will be made without regard to gender, race or ethnicity. ..
  44. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
    ..Demonstrating such fundamental differences may lead to different approaches in attempts to modify antisocial behavior among high risk populations with such behavioral tendencies. ..
  45. Screening for comorbidity in substance abuse clinics
    Carlos Blanco; Fiscal Year: 2004
    ..abstract_text> ..
  46. Surrogate Biomarkers of Micrometastatic Gastric Cancer
    Adam Smolka; Fiscal Year: 2004
    ..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
  47. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2004
    ..Awards will be made without regard to gender, race, ethnicity or disability. ..
  48. Expression of Therapeutic Proteins in the Whole Lens
    Dolores Takemoto; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  49. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2006
    ..abstract_text> ..
  50. INNOVATIVE BIOMONITORING FOR LEAD IN SALIVA
    Charles Timchalk; Fiscal Year: 2006
    ..It is reasonable to speculate that once this model system has been adequately validated it can readily be employed to screen sensitive populations (e.g. children) that are at greatest risk from chronic Pb exposure. ..
  51. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
    ..Pharmacological effects of these therapeutics drugs on such behavior in a high risk population may provide information relating to alternative strategies in dealing with drug dependence. ..
  52. Peripherial and Central Mechanisms of Tinnitus Generat
    Carol Bauer; Fiscal Year: 2006
    ..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
  53. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
  54. Pretargeting mouse tumor with anti-PSMA antibody-MORF
    Guozheng Liu; Fiscal Year: 2005
    ..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
  55. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....
  56. CHRONIC CENTRAL PAIN IN SPINAL CORD INJURY
    CLAIRE HULSEBOSCH; Fiscal Year: 2005
    ..There are three cores: an administrative core, an animal core and a morphology core. The results for these studies will guide the development of strategic interventions to improve functional outcome after SCI. ..
  57. RELEASE CHANNEL ISOFORMS AND LOCAL CALCIUM SIGNALING
    Natalia Shirokova; Fiscal Year: 2003
    ..Proposed studies will greatly advanced our knowledge of their functioning, which in turn could improve our understanding of their role in decease. ..
  58. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  59. Third Symposium Cell Volume & Signalling Regulation
    PETER LAUF; Fiscal Year: 2003
    ..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
  60. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  61. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..